

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.46231381 |
| 2 | DNA deamination (GO:0045006) | 5.39681593 |
| 3 | ribosomal small subunit assembly (GO:0000028) | 5.24623445 |
| 4 | viral transcription (GO:0019083) | 4.80970385 |
| 5 | ribosomal small subunit biogenesis (GO:0042274) | 4.80410657 |
| 6 | translational termination (GO:0006415) | 4.74794335 |
| 7 | proteasome assembly (GO:0043248) | 4.70870130 |
| 8 | CENP-A containing nucleosome assembly (GO:0034080) | 4.67405407 |
| 9 | chromatin remodeling at centromere (GO:0031055) | 4.56623163 |
| 10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.55304892 |
| 11 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.50616925 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 4.49849604 |
| 13 | ribosomal large subunit biogenesis (GO:0042273) | 4.46362103 |
| 14 | protein targeting to ER (GO:0045047) | 4.42925720 |
| 15 | kinetochore assembly (GO:0051382) | 4.31909634 |
| 16 | kinetochore organization (GO:0051383) | 4.30930510 |
| 17 | protein localization to endoplasmic reticulum (GO:0070972) | 4.24212905 |
| 18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.17207941 |
| 19 | mitotic metaphase plate congression (GO:0007080) | 4.16577126 |
| 20 | translational elongation (GO:0006414) | 4.12892407 |
| 21 | ATP synthesis coupled proton transport (GO:0015986) | 4.11089552 |
| 22 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.11089552 |
| 23 | chaperone-mediated protein transport (GO:0072321) | 4.03353040 |
| 24 | maturation of SSU-rRNA (GO:0030490) | 4.01190650 |
| 25 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.88644577 |
| 26 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.88644577 |
| 27 | translational initiation (GO:0006413) | 3.87806971 |
| 28 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.84735313 |
| 29 | DNA replication-independent nucleosome organization (GO:0034724) | 3.84735313 |
| 30 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.82027506 |
| 31 | termination of RNA polymerase III transcription (GO:0006386) | 3.82027506 |
| 32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.79800847 |
| 33 | cellular protein complex disassembly (GO:0043624) | 3.76603487 |
| 34 | translation (GO:0006412) | 3.75073938 |
| 35 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.74580157 |
| 36 | DNA replication checkpoint (GO:0000076) | 3.69520827 |
| 37 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.68280074 |
| 38 | protein deneddylation (GO:0000338) | 3.68150365 |
| 39 | spliceosomal snRNP assembly (GO:0000387) | 3.67837451 |
| 40 | viral life cycle (GO:0019058) | 3.67456239 |
| 41 | metaphase plate congression (GO:0051310) | 3.67248041 |
| 42 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.67196142 |
| 43 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.67124832 |
| 44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.65167717 |
| 45 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.63696047 |
| 46 | histone exchange (GO:0043486) | 3.63392044 |
| 47 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.62939159 |
| 48 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.59041449 |
| 49 | cullin deneddylation (GO:0010388) | 3.58249397 |
| 50 | DNA damage response, detection of DNA damage (GO:0042769) | 3.57885653 |
| 51 | respiratory chain complex IV assembly (GO:0008535) | 3.56239601 |
| 52 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.56228241 |
| 53 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.56228241 |
| 54 | NADH dehydrogenase complex assembly (GO:0010257) | 3.56228241 |
| 55 | spliceosomal complex assembly (GO:0000245) | 3.54853216 |
| 56 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.54317007 |
| 57 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.53104522 |
| 58 | 7-methylguanosine mRNA capping (GO:0006370) | 3.53052409 |
| 59 | 7-methylguanosine RNA capping (GO:0009452) | 3.52256122 |
| 60 | RNA capping (GO:0036260) | 3.52256122 |
| 61 | establishment of integrated proviral latency (GO:0075713) | 3.49598567 |
| 62 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.48534906 |
| 63 | protein complex biogenesis (GO:0070271) | 3.47579332 |
| 64 | maturation of 5.8S rRNA (GO:0000460) | 3.47529959 |
| 65 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.47512858 |
| 66 | rRNA modification (GO:0000154) | 3.46576833 |
| 67 | regulation of mitochondrial translation (GO:0070129) | 3.41967057 |
| 68 | negative regulation of ligase activity (GO:0051352) | 3.41164398 |
| 69 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.41164398 |
| 70 | cellular component biogenesis (GO:0044085) | 3.39524898 |
| 71 | telomere maintenance via recombination (GO:0000722) | 3.38617084 |
| 72 | respiratory electron transport chain (GO:0022904) | 3.38307879 |
| 73 | rRNA processing (GO:0006364) | 3.34951885 |
| 74 | protein localization to mitochondrion (GO:0070585) | 3.34469710 |
| 75 | establishment of protein localization to mitochondrion (GO:0072655) | 3.34003969 |
| 76 | inner mitochondrial membrane organization (GO:0007007) | 3.32833670 |
| 77 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.32192976 |
| 78 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.31957964 |
| 79 | cytochrome complex assembly (GO:0017004) | 3.31886023 |
| 80 | histone mRNA metabolic process (GO:0008334) | 3.30194356 |
| 81 | DNA strand elongation (GO:0022616) | 3.30169374 |
| 82 | purine nucleobase biosynthetic process (GO:0009113) | 3.29375053 |
| 83 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.29336784 |
| 84 | ATP biosynthetic process (GO:0006754) | 3.28631794 |
| 85 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.27045827 |
| 86 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.27045827 |
| 87 | electron transport chain (GO:0022900) | 3.26981580 |
| 88 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.26130344 |
| 89 | establishment of chromosome localization (GO:0051303) | 3.24683482 |
| 90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.22107225 |
| 91 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.22107225 |
| 92 | protein complex disassembly (GO:0043241) | 3.21833941 |
| 93 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.21740521 |
| 94 | protein neddylation (GO:0045116) | 3.20579130 |
| 95 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.19057107 |
| 96 | rRNA metabolic process (GO:0016072) | 3.18848228 |
| 97 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.18739625 |
| 98 | DNA double-strand break processing (GO:0000729) | 3.18039474 |
| 99 | hydrogen ion transmembrane transport (GO:1902600) | 3.17820317 |
| 100 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.17415860 |
| 101 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.17088607 |
| 102 | mitotic recombination (GO:0006312) | 3.15897796 |
| 103 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.15141997 |
| 104 | GTP biosynthetic process (GO:0006183) | 3.14579125 |
| 105 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.14035327 |
| 106 | macromolecular complex disassembly (GO:0032984) | 3.11961290 |
| 107 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.11779787 |
| 108 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.11779787 |
| 109 | sequestering of actin monomers (GO:0042989) | 3.11710801 |
| 110 | ribosome assembly (GO:0042255) | 3.10668700 |
| 111 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.09915158 |
| 112 | nucleobase biosynthetic process (GO:0046112) | 3.09712589 |
| 113 | protein targeting to mitochondrion (GO:0006626) | 3.09051478 |
| 114 | positive regulation of ligase activity (GO:0051351) | 3.08676512 |
| 115 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.08652063 |
| 116 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.08652063 |
| 117 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.08652063 |
| 118 | pseudouridine synthesis (GO:0001522) | 3.07033362 |
| 119 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.06945455 |
| 120 | DNA replication initiation (GO:0006270) | 3.06628082 |
| 121 | regulation of helicase activity (GO:0051095) | 2.98280971 |
| 122 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.96135452 |
| 123 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.96135452 |
| 124 | replication fork processing (GO:0031297) | 2.93035703 |
| 125 | intracellular protein transmembrane import (GO:0044743) | 2.91891032 |
| 126 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.89567644 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.08847926 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.98957775 |
| 3 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.55479573 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.30107280 |
| 5 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.05034674 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.65955663 |
| 7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.56756830 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.52455863 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.42751798 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.40186296 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.37954193 |
| 12 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.33596132 |
| 13 | * HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.24120951 |
| 14 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.96063560 |
| 15 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.95876078 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.91897859 |
| 17 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.82355119 |
| 18 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.75776741 |
| 19 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.73239899 |
| 20 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.70824035 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.67654811 |
| 22 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.56351576 |
| 23 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.49969095 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.46809531 |
| 25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.46334762 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.46223157 |
| 27 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.38499261 |
| 28 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.37041899 |
| 29 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.23773387 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.21248292 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.17017561 |
| 32 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.15328148 |
| 33 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.14288509 |
| 34 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.13740038 |
| 35 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.12962067 |
| 36 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.12798738 |
| 37 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.03953613 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.03842293 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.02852835 |
| 40 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.00779349 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.90720928 |
| 42 | VDR_22108803_ChIP-Seq_LS180_Human | 1.88555106 |
| 43 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.88285789 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.84271230 |
| 45 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.82908172 |
| 46 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.70237722 |
| 47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.66027120 |
| 48 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.64836570 |
| 49 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.61994502 |
| 50 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.59641289 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.56938411 |
| 52 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.55500255 |
| 53 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.53059420 |
| 54 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.52641420 |
| 55 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.49875290 |
| 56 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.45944366 |
| 57 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.43345861 |
| 58 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.40175525 |
| 59 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.38860993 |
| 60 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.38381153 |
| 61 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.37740243 |
| 62 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.37231000 |
| 63 | * TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35898266 |
| 64 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.34093737 |
| 65 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.29137397 |
| 66 | * ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.28763667 |
| 67 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.25987664 |
| 68 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.24224638 |
| 69 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.24010415 |
| 70 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.22825061 |
| 71 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.19389489 |
| 72 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.18000047 |
| 73 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13291130 |
| 74 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.11958055 |
| 75 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.11882978 |
| 76 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.08544632 |
| 77 | P300_19829295_ChIP-Seq_ESCs_Human | 1.07395636 |
| 78 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.07178524 |
| 79 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.06764300 |
| 80 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.06279490 |
| 81 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.06177971 |
| 82 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.05158509 |
| 83 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.05068425 |
| 84 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.04199800 |
| 85 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.02152221 |
| 86 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.00762112 |
| 87 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.00660786 |
| 88 | * EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.00367821 |
| 89 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.99657129 |
| 90 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.99378475 |
| 91 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.99292961 |
| 92 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.99282746 |
| 93 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97104649 |
| 94 | EWS_26573619_Chip-Seq_HEK293_Human | 0.97037772 |
| 95 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.96705306 |
| 96 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.96353157 |
| 97 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.95751557 |
| 98 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.95587898 |
| 99 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.94866845 |
| 100 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.94090813 |
| 101 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.92266737 |
| 102 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.89464116 |
| 103 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.88604198 |
| 104 | FUS_26573619_Chip-Seq_HEK293_Human | 0.87285878 |
| 105 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.83793129 |
| 106 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.83652502 |
| 107 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.82023047 |
| 108 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.81080538 |
| 109 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.79349580 |
| 110 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.76575113 |
| 111 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.76575113 |
| 112 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.76221883 |
| 113 | * AR_20517297_ChIP-Seq_VCAP_Human | 0.73533515 |
| 114 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.73232241 |
| 115 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.72863388 |
| 116 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.72542194 |
| 117 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.71821674 |
| 118 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.71634706 |
| 119 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.70165232 |
| 120 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.68941130 |
| 121 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.67536841 |
| 122 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.67067635 |
| 123 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.66970242 |
| 124 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.64301417 |
| 125 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.63003604 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.79248603 |
| 2 | MP0009379_abnormal_foot_pigmentation | 4.17777215 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.74486337 |
| 4 | MP0001529_abnormal_vocalization | 2.97370446 |
| 5 | MP0003077_abnormal_cell_cycle | 2.93007924 |
| 6 | MP0003123_paternal_imprinting | 2.86951891 |
| 7 | MP0010094_abnormal_chromosome_stability | 2.85918993 |
| 8 | MP0003315_abnormal_perineum_morphology | 2.79478505 |
| 9 | MP0009697_abnormal_copulation | 2.79232595 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.76624927 |
| 11 | MP0003718_maternal_effect | 2.73552014 |
| 12 | MP0003111_abnormal_nucleus_morphology | 2.65618576 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.58800632 |
| 14 | MP0005408_hypopigmentation | 2.49982295 |
| 15 | MP0006292_abnormal_olfactory_placode | 2.42041273 |
| 16 | MP0002102_abnormal_ear_morphology | 2.34629974 |
| 17 | MP0008007_abnormal_cellular_replicative | 2.24487239 |
| 18 | MP0003186_abnormal_redox_activity | 2.12560196 |
| 19 | MP0002139_abnormal_hepatobiliary_system | 2.09813102 |
| 20 | MP0008058_abnormal_DNA_repair | 2.04091283 |
| 21 | MP0003136_yellow_coat_color | 1.84354216 |
| 22 | MP0004147_increased_porphyrin_level | 1.79932085 |
| 23 | MP0002938_white_spotting | 1.79680935 |
| 24 | MP0009053_abnormal_anal_canal | 1.72748892 |
| 25 | MP0000372_irregular_coat_pigmentation | 1.72607085 |
| 26 | MP0010030_abnormal_orbit_morphology | 1.71289338 |
| 27 | MP0002160_abnormal_reproductive_system | 1.66515965 |
| 28 | MP0008789_abnormal_olfactory_epithelium | 1.63732793 |
| 29 | MP0005085_abnormal_gallbladder_physiolo | 1.61934033 |
| 30 | MP0005360_urolithiasis | 1.58102343 |
| 31 | MP0003786_premature_aging | 1.55512573 |
| 32 | MP0003121_genomic_imprinting | 1.53197791 |
| 33 | MP0004142_abnormal_muscle_tone | 1.48408382 |
| 34 | MP0000566_synostosis | 1.46509743 |
| 35 | MP0008057_abnormal_DNA_replication | 1.45654900 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.44771892 |
| 37 | MP0003195_calcinosis | 1.42478178 |
| 38 | MP0006036_abnormal_mitochondrial_physio | 1.42073976 |
| 39 | MP0002736_abnormal_nociception_after | 1.41795278 |
| 40 | MP0005389_reproductive_system_phenotype | 1.40488113 |
| 41 | MP0008995_early_reproductive_senescence | 1.39969219 |
| 42 | MP0006054_spinal_hemorrhage | 1.38248414 |
| 43 | MP0003656_abnormal_erythrocyte_physiolo | 1.35801311 |
| 44 | MP0002751_abnormal_autonomic_nervous | 1.31981407 |
| 45 | MP0005253_abnormal_eye_physiology | 1.31274866 |
| 46 | MP0004133_heterotaxia | 1.30928663 |
| 47 | MP0005084_abnormal_gallbladder_morpholo | 1.30441911 |
| 48 | MP0000049_abnormal_middle_ear | 1.30004156 |
| 49 | MP0008877_abnormal_DNA_methylation | 1.28375045 |
| 50 | MP0003941_abnormal_skin_development | 1.26998650 |
| 51 | MP0002234_abnormal_pharynx_morphology | 1.25809759 |
| 52 | MP0000490_abnormal_crypts_of | 1.25644245 |
| 53 | MP0001188_hyperpigmentation | 1.24608601 |
| 54 | MP0003011_delayed_dark_adaptation | 1.23513582 |
| 55 | MP0005220_abnormal_exocrine_pancreas | 1.23182914 |
| 56 | MP0005551_abnormal_eye_electrophysiolog | 1.23007672 |
| 57 | MP0001119_abnormal_female_reproductive | 1.21875500 |
| 58 | MP0003937_abnormal_limbs/digits/tail_de | 1.20466677 |
| 59 | MP0005646_abnormal_pituitary_gland | 1.18363294 |
| 60 | MP0002638_abnormal_pupillary_reflex | 1.17934416 |
| 61 | MP0001730_embryonic_growth_arrest | 1.17603571 |
| 62 | MP0002277_abnormal_respiratory_mucosa | 1.14998052 |
| 63 | MP0000350_abnormal_cell_proliferation | 1.14889694 |
| 64 | MP0009250_abnormal_appendicular_skeleto | 1.14604063 |
| 65 | MP0002163_abnormal_gland_morphology | 1.13517988 |
| 66 | MP0003880_abnormal_central_pattern | 1.10033589 |
| 67 | MP0006035_abnormal_mitochondrial_morpho | 1.07695469 |
| 68 | MP0002138_abnormal_hepatobiliary_system | 1.07062842 |
| 69 | MP0000647_abnormal_sebaceous_gland | 1.05190650 |
| 70 | MP0002210_abnormal_sex_determination | 1.05186243 |
| 71 | MP0001764_abnormal_homeostasis | 1.05170990 |
| 72 | MP0002396_abnormal_hematopoietic_system | 1.01788473 |
| 73 | MP0005636_abnormal_mineral_homeostasis | 0.98997533 |
| 74 | MP0008872_abnormal_physiological_respon | 0.98974520 |
| 75 | MP0001697_abnormal_embryo_size | 0.98739246 |
| 76 | MP0002132_abnormal_respiratory_system | 0.98559338 |
| 77 | MP0000653_abnormal_sex_gland | 0.97021889 |
| 78 | MP0003942_abnormal_urinary_system | 0.95345116 |
| 79 | MP0002653_abnormal_ependyma_morphology | 0.94633184 |
| 80 | MP0005365_abnormal_bile_salt | 0.94586472 |
| 81 | MP0002282_abnormal_trachea_morphology | 0.94490010 |
| 82 | MP0003938_abnormal_ear_development | 0.93647907 |
| 83 | MP0001919_abnormal_reproductive_system | 0.93275113 |
| 84 | MP0008875_abnormal_xenobiotic_pharmacok | 0.91427480 |
| 85 | MP0001968_abnormal_touch/_nociception | 0.90752830 |
| 86 | MP0005394_taste/olfaction_phenotype | 0.90526196 |
| 87 | MP0005499_abnormal_olfactory_system | 0.90526196 |
| 88 | MP0001145_abnormal_male_reproductive | 0.89957942 |
| 89 | MP0003890_abnormal_embryonic-extraembry | 0.89372177 |
| 90 | MP0005391_vision/eye_phenotype | 0.88852759 |
| 91 | MP0005503_abnormal_tendon_morphology | 0.88665023 |
| 92 | MP0002233_abnormal_nose_morphology | 0.88457970 |
| 93 | MP0001984_abnormal_olfaction | 0.86017140 |
| 94 | MP0009046_muscle_twitch | 0.84562246 |
| 95 | MP0001286_abnormal_eye_development | 0.83963024 |
| 96 | MP0005195_abnormal_posterior_eye | 0.83447380 |
| 97 | MP0003787_abnormal_imprinting | 0.83251357 |
| 98 | MP0000313_abnormal_cell_death | 0.82242658 |
| 99 | MP0001672_abnormal_embryogenesis/_devel | 0.81676680 |
| 100 | MP0005380_embryogenesis_phenotype | 0.81676680 |
| 101 | MP0002085_abnormal_embryonic_tissue | 0.81551902 |
| 102 | MP0003385_abnormal_body_wall | 0.80986467 |
| 103 | MP0002080_prenatal_lethality | 0.79985018 |
| 104 | MP0005379_endocrine/exocrine_gland_phen | 0.79874405 |
| 105 | MP0001929_abnormal_gametogenesis | 0.79739766 |
| 106 | MP0003698_abnormal_male_reproductive | 0.79095956 |
| 107 | MP0005075_abnormal_melanosome_morpholog | 0.77530009 |
| 108 | MP0004145_abnormal_muscle_electrophysio | 0.77463389 |
| 109 | MP0005187_abnormal_penis_morphology | 0.77459543 |
| 110 | MP0001905_abnormal_dopamine_level | 0.76303066 |
| 111 | MP0005395_other_phenotype | 0.75969157 |
| 112 | MP0000631_abnormal_neuroendocrine_gland | 0.75460363 |
| 113 | MP0001485_abnormal_pinna_reflex | 0.74334713 |
| 114 | MP0004215_abnormal_myocardial_fiber | 0.73650657 |
| 115 | MP0002697_abnormal_eye_size | 0.73611949 |
| 116 | MP0002090_abnormal_vision | 0.72934125 |
| 117 | MP0003567_abnormal_fetal_cardiomyocyte | 0.71982205 |
| 118 | MP0000613_abnormal_salivary_gland | 0.71410139 |
| 119 | MP0005410_abnormal_fertilization | 0.70309613 |
| 120 | MP0003122_maternal_imprinting | 0.69417179 |
| 121 | MP0003868_abnormal_feces_composition | 0.69060397 |
| 122 | MP0003119_abnormal_digestive_system | 0.69012693 |
| 123 | MP0003984_embryonic_growth_retardation | 0.68247922 |
| 124 | MP0003755_abnormal_palate_morphology | 0.68057302 |
| 125 | MP0006072_abnormal_retinal_apoptosis | 0.67214152 |
| 126 | MP0002095_abnormal_skin_pigmentation | 0.66823204 |
| 127 | MP0008004_abnormal_stomach_pH | 0.65172331 |
| 128 | MP0003699_abnormal_female_reproductive | 0.64977517 |
| 129 | MP0002088_abnormal_embryonic_growth/wei | 0.64666531 |
| 130 | MP0006276_abnormal_autonomic_nervous | 0.63833894 |
| 131 | MP0009672_abnormal_birth_weight | 0.63135395 |
| 132 | MP0001293_anophthalmia | 0.61261566 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.94586730 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.66037456 |
| 3 | Mitochondrial inheritance (HP:0001427) | 4.41569524 |
| 4 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.33483583 |
| 5 | Acute encephalopathy (HP:0006846) | 4.21423394 |
| 6 | Abnormal number of erythroid precursors (HP:0012131) | 4.17592100 |
| 7 | Reticulocytopenia (HP:0001896) | 4.15232217 |
| 8 | Progressive macrocephaly (HP:0004481) | 4.09608597 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 4.04030139 |
| 10 | Increased CSF lactate (HP:0002490) | 3.96961921 |
| 11 | Birth length less than 3rd percentile (HP:0003561) | 3.95305954 |
| 12 | Hepatocellular necrosis (HP:0001404) | 3.89239213 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.79618565 |
| 14 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.79618565 |
| 15 | Aplastic anemia (HP:0001915) | 3.72201883 |
| 16 | Hepatic necrosis (HP:0002605) | 3.67968404 |
| 17 | Lipid accumulation in hepatocytes (HP:0006561) | 3.65240212 |
| 18 | Oral leukoplakia (HP:0002745) | 3.64261158 |
| 19 | Macrocytic anemia (HP:0001972) | 3.28037349 |
| 20 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.24998398 |
| 21 | Breast hypoplasia (HP:0003187) | 3.24719350 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.24719331 |
| 23 | Increased serum lactate (HP:0002151) | 3.15400057 |
| 24 | Cerebral edema (HP:0002181) | 3.10556415 |
| 25 | Increased intramyocellular lipid droplets (HP:0012240) | 3.08204906 |
| 26 | Renal Fanconi syndrome (HP:0001994) | 3.06160173 |
| 27 | Exertional dyspnea (HP:0002875) | 3.05726484 |
| 28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.98657511 |
| 29 | Pallor (HP:0000980) | 2.92437321 |
| 30 | 3-Methylglutaconic aciduria (HP:0003535) | 2.87700286 |
| 31 | Abnormality of the labia minora (HP:0012880) | 2.84254247 |
| 32 | Abnormality of glycolysis (HP:0004366) | 2.73632689 |
| 33 | Increased serum pyruvate (HP:0003542) | 2.73632689 |
| 34 | Lactic acidosis (HP:0003128) | 2.72111031 |
| 35 | Abnormality of midbrain morphology (HP:0002418) | 2.67415283 |
| 36 | Molar tooth sign on MRI (HP:0002419) | 2.67415283 |
| 37 | Exercise intolerance (HP:0003546) | 2.67398548 |
| 38 | Methylmalonic acidemia (HP:0002912) | 2.50261277 |
| 39 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.49711943 |
| 40 | Increased muscle lipid content (HP:0009058) | 2.49538444 |
| 41 | Irregular epiphyses (HP:0010582) | 2.49452160 |
| 42 | Respiratory failure (HP:0002878) | 2.46880808 |
| 43 | Patellar aplasia (HP:0006443) | 2.44900715 |
| 44 | Rough bone trabeculation (HP:0100670) | 2.43469926 |
| 45 | Medial flaring of the eyebrow (HP:0010747) | 2.41304971 |
| 46 | Respiratory difficulties (HP:0002880) | 2.38622139 |
| 47 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.33728686 |
| 48 | Nephronophthisis (HP:0000090) | 2.33618067 |
| 49 | Leukodystrophy (HP:0002415) | 2.30792495 |
| 50 | Optic disc pallor (HP:0000543) | 2.30523584 |
| 51 | Secondary amenorrhea (HP:0000869) | 2.29139649 |
| 52 | Type I transferrin isoform profile (HP:0003642) | 2.28235539 |
| 53 | Abnormality of urine glucose concentration (HP:0011016) | 2.28082092 |
| 54 | Glycosuria (HP:0003076) | 2.28082092 |
| 55 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.26367977 |
| 56 | Septo-optic dysplasia (HP:0100842) | 2.24421446 |
| 57 | Carpal bone hypoplasia (HP:0001498) | 2.21449750 |
| 58 | Abnormal lung lobation (HP:0002101) | 2.20889735 |
| 59 | Capillary hemangiomas (HP:0005306) | 2.20552104 |
| 60 | Pendular nystagmus (HP:0012043) | 2.18293307 |
| 61 | Microretrognathia (HP:0000308) | 2.17823867 |
| 62 | Horseshoe kidney (HP:0000085) | 2.16145558 |
| 63 | Methylmalonic aciduria (HP:0012120) | 2.13933811 |
| 64 | Pancreatic cysts (HP:0001737) | 2.13136761 |
| 65 | Hyperglycinemia (HP:0002154) | 2.12278437 |
| 66 | Cerebral hypomyelination (HP:0006808) | 2.10400302 |
| 67 | Abnormal hemoglobin (HP:0011902) | 2.09165085 |
| 68 | Lethargy (HP:0001254) | 2.07911437 |
| 69 | Hyperphosphaturia (HP:0003109) | 2.07369383 |
| 70 | Abnormality of renal resorption (HP:0011038) | 2.04338813 |
| 71 | Abnormality of chromosome stability (HP:0003220) | 2.04162175 |
| 72 | Chromsome breakage (HP:0040012) | 2.02305776 |
| 73 | Abnormality of serum amino acid levels (HP:0003112) | 2.00606575 |
| 74 | Abnormality of the anterior horn cell (HP:0006802) | 1.99683130 |
| 75 | Degeneration of anterior horn cells (HP:0002398) | 1.99683130 |
| 76 | 11 pairs of ribs (HP:0000878) | 1.99142127 |
| 77 | Microvesicular hepatic steatosis (HP:0001414) | 1.98313291 |
| 78 | Absent septum pellucidum (HP:0001331) | 1.98170993 |
| 79 | Triphalangeal thumb (HP:0001199) | 1.98050565 |
| 80 | Hypobetalipoproteinemia (HP:0003563) | 1.96324893 |
| 81 | Supernumerary spleens (HP:0009799) | 1.95045413 |
| 82 | Colon cancer (HP:0003003) | 1.94609609 |
| 83 | Abnormality of the pons (HP:0007361) | 1.94010715 |
| 84 | Premature graying of hair (HP:0002216) | 1.93585091 |
| 85 | Facial hemangioma (HP:0000329) | 1.92857794 |
| 86 | Amniotic constriction ring (HP:0009775) | 1.92813869 |
| 87 | Abnormality of placental membranes (HP:0011409) | 1.92813869 |
| 88 | Bifid tongue (HP:0010297) | 1.92233714 |
| 89 | Sclerocornea (HP:0000647) | 1.90826651 |
| 90 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.90772506 |
| 91 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.90772506 |
| 92 | Abnormal protein glycosylation (HP:0012346) | 1.90772506 |
| 93 | Abnormal glycosylation (HP:0012345) | 1.90772506 |
| 94 | Congenital primary aphakia (HP:0007707) | 1.89342401 |
| 95 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.89291063 |
| 96 | Meckel diverticulum (HP:0002245) | 1.88534959 |
| 97 | Hypoplasia of the pons (HP:0012110) | 1.87004420 |
| 98 | Congenital, generalized hypertrichosis (HP:0004540) | 1.86199088 |
| 99 | Abnormal trabecular bone morphology (HP:0100671) | 1.85150004 |
| 100 | Reduced antithrombin III activity (HP:0001976) | 1.84602501 |
| 101 | Stenosis of the external auditory canal (HP:0000402) | 1.83162364 |
| 102 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.83065617 |
| 103 | Abnormality of the renal medulla (HP:0100957) | 1.82366221 |
| 104 | Nephrogenic diabetes insipidus (HP:0009806) | 1.82045787 |
| 105 | Flat capital femoral epiphysis (HP:0003370) | 1.81413083 |
| 106 | X-linked dominant inheritance (HP:0001423) | 1.81383958 |
| 107 | Abnormality of alanine metabolism (HP:0010916) | 1.80509950 |
| 108 | Hyperalaninemia (HP:0003348) | 1.80509950 |
| 109 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.80509950 |
| 110 | CNS demyelination (HP:0007305) | 1.80333794 |
| 111 | Abnormality of the septum pellucidum (HP:0007375) | 1.79935814 |
| 112 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.79527332 |
| 113 | Adrenal hypoplasia (HP:0000835) | 1.79513258 |
| 114 | Redundant skin (HP:0001582) | 1.79193929 |
| 115 | Cleft eyelid (HP:0000625) | 1.79056036 |
| 116 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.78556613 |
| 117 | Abnormality of the preputium (HP:0100587) | 1.77949303 |
| 118 | Gait imbalance (HP:0002141) | 1.77747406 |
| 119 | Abnormality of methionine metabolism (HP:0010901) | 1.77665481 |
| 120 | Absent thumb (HP:0009777) | 1.77076514 |
| 121 | Abnormality of the ileum (HP:0001549) | 1.75176965 |
| 122 | Self-mutilation (HP:0000742) | 1.74479223 |
| 123 | Pancreatic fibrosis (HP:0100732) | 1.72731262 |
| 124 | Pancytopenia (HP:0001876) | 1.72223733 |
| 125 | Median cleft lip (HP:0000161) | 1.72089965 |
| 126 | Absent radius (HP:0003974) | 1.71645074 |
| 127 | Unsteady gait (HP:0002317) | 1.71106377 |
| 128 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.70896805 |
| 129 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.70465513 |
| 130 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.70433358 |
| 131 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.68334696 |
| 132 | Embryonal renal neoplasm (HP:0011794) | 1.68203612 |
| 133 | Genital tract atresia (HP:0001827) | 1.67722243 |
| 134 | Diastasis recti (HP:0001540) | 1.67187420 |
| 135 | True hermaphroditism (HP:0010459) | 1.66866522 |
| 136 | Bilateral microphthalmos (HP:0007633) | 1.66611370 |
| 137 | Hypothermia (HP:0002045) | 1.65867607 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.35722922 |
| 2 | BUB1 | 4.23966208 |
| 3 | STK16 | 3.63339524 |
| 4 | EIF2AK1 | 3.57788613 |
| 5 | NME2 | 3.29627657 |
| 6 | SRPK1 | 3.08438402 |
| 7 | WEE1 | 2.82518267 |
| 8 | CDC7 | 2.69479121 |
| 9 | ACVR1B | 2.60835586 |
| 10 | VRK1 | 2.58172577 |
| 11 | PLK4 | 2.47940794 |
| 12 | CDK8 | 2.07184229 |
| 13 | EIF2AK3 | 1.99784541 |
| 14 | BRSK2 | 1.96908459 |
| 15 | TESK2 | 1.95554022 |
| 16 | NME1 | 1.95369320 |
| 17 | TLK1 | 1.92126252 |
| 18 | MAP4K2 | 1.80576812 |
| 19 | TRIM28 | 1.75399148 |
| 20 | PBK | 1.73916511 |
| 21 | BRAF | 1.72154396 |
| 22 | TAF1 | 1.67601095 |
| 23 | PLK1 | 1.64208573 |
| 24 | CCNB1 | 1.64011026 |
| 25 | BMPR1B | 1.63509932 |
| 26 | NEK1 | 1.61405369 |
| 27 | BRSK1 | 1.57442080 |
| 28 | PIM2 | 1.56155258 |
| 29 | MKNK1 | 1.54210344 |
| 30 | STK38L | 1.52458206 |
| 31 | TTK | 1.51434202 |
| 32 | DYRK2 | 1.46108810 |
| 33 | AURKB | 1.41716972 |
| 34 | PNCK | 1.38522130 |
| 35 | PLK3 | 1.36981991 |
| 36 | PINK1 | 1.36414715 |
| 37 | MAP3K4 | 1.32922190 |
| 38 | DYRK3 | 1.29004113 |
| 39 | LIMK1 | 1.27830441 |
| 40 | AURKA | 1.25592698 |
| 41 | MST4 | 1.24998002 |
| 42 | MKNK2 | 1.21205988 |
| 43 | ARAF | 1.16930976 |
| 44 | ZAK | 1.16818640 |
| 45 | TESK1 | 1.14498777 |
| 46 | ABL2 | 1.11724352 |
| 47 | ADRBK2 | 1.11299948 |
| 48 | MELK | 1.10571412 |
| 49 | NUAK1 | 1.04452638 |
| 50 | TGFBR1 | 1.04300400 |
| 51 | ERBB3 | 1.01556288 |
| 52 | MUSK | 1.01246461 |
| 53 | GRK1 | 1.01033164 |
| 54 | TNIK | 1.00122739 |
| 55 | MAP3K12 | 0.98804979 |
| 56 | MAP3K6 | 0.97464848 |
| 57 | NEK2 | 0.94045536 |
| 58 | LATS2 | 0.90878610 |
| 59 | BCKDK | 0.90144059 |
| 60 | CDK7 | 0.89844554 |
| 61 | EIF2AK2 | 0.87472528 |
| 62 | CHEK2 | 0.87119768 |
| 63 | ERBB4 | 0.83367111 |
| 64 | FRK | 0.81098859 |
| 65 | ATR | 0.80649015 |
| 66 | INSRR | 0.79888642 |
| 67 | ILK | 0.77947581 |
| 68 | MAP2K7 | 0.75897226 |
| 69 | NEK9 | 0.75639858 |
| 70 | CSNK2A1 | 0.75207885 |
| 71 | MAPK13 | 0.74256388 |
| 72 | RAF1 | 0.70790781 |
| 73 | RPS6KA4 | 0.67402780 |
| 74 | PDK2 | 0.66352117 |
| 75 | KDR | 0.62292370 |
| 76 | RPS6KB2 | 0.61924336 |
| 77 | CSNK1G3 | 0.60517544 |
| 78 | BCR | 0.59806671 |
| 79 | TIE1 | 0.58809118 |
| 80 | CSNK1A1L | 0.58498564 |
| 81 | CSNK2A2 | 0.57344365 |
| 82 | CSNK1G1 | 0.57038442 |
| 83 | NEK6 | 0.56041427 |
| 84 | CHEK1 | 0.55138970 |
| 85 | PLK2 | 0.54832095 |
| 86 | OXSR1 | 0.54590204 |
| 87 | PRKCG | 0.52658873 |
| 88 | CDK3 | 0.50093689 |
| 89 | MARK1 | 0.49796255 |
| 90 | MAPKAPK5 | 0.46245248 |
| 91 | MOS | 0.45782425 |
| 92 | MAP3K8 | 0.45764587 |
| 93 | STK3 | 0.44758927 |
| 94 | ATM | 0.42507164 |
| 95 | CSNK1E | 0.42249713 |
| 96 | CDK19 | 0.41993510 |
| 97 | PASK | 0.41795018 |
| 98 | PAK1 | 0.38758836 |
| 99 | NLK | 0.38502649 |
| 100 | TSSK6 | 0.37427069 |
| 101 | STK4 | 0.37062812 |
| 102 | MYLK | 0.35706031 |
| 103 | CDK1 | 0.35579553 |
| 104 | CDK2 | 0.35505996 |
| 105 | PRKCE | 0.34541106 |
| 106 | MAP3K11 | 0.34067243 |
| 107 | MINK1 | 0.33637223 |
| 108 | CSNK1A1 | 0.33569833 |
| 109 | YES1 | 0.32913089 |
| 110 | PRKCI | 0.31731604 |
| 111 | EPHB2 | 0.31711442 |
| 112 | STK39 | 0.31671015 |
| 113 | FLT3 | 0.30318183 |
| 114 | MAPK15 | 0.30238546 |
| 115 | WNK4 | 0.29870828 |
| 116 | PIK3CG | 0.29707262 |
| 117 | IRAK3 | 0.29654942 |
| 118 | WNK3 | 0.29319413 |
| 119 | GRK7 | 0.29241860 |
| 120 | DAPK1 | 0.28698952 |
| 121 | KSR1 | 0.28595836 |
| 122 | TEC | 0.28412271 |
| 123 | ADRBK1 | 0.27080778 |
| 124 | TBK1 | 0.27029029 |
| 125 | CSNK1G2 | 0.26544854 |
| 126 | CDK14 | 0.25701294 |
| 127 | CDK18 | 0.25574242 |
| 128 | RPS6KA5 | 0.24097992 |
| 129 | BMPR2 | 0.22789113 |
| 130 | CASK | 0.21447071 |
| 131 | CDK11A | 0.21352335 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.75178829 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.93120851 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.70899033 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.60004136 |
| 5 | Protein export_Homo sapiens_hsa03060 | 3.26081511 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.92625870 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.74821614 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.71607541 |
| 9 | Parkinsons disease_Homo sapiens_hsa05012 | 2.71473754 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.69313129 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.65206666 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 2.53996985 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.19258179 |
| 14 | Huntingtons disease_Homo sapiens_hsa05016 | 2.17117952 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 2.14499463 |
| 16 | Base excision repair_Homo sapiens_hsa03410 | 2.02900887 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.99380463 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.93833387 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.92510613 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.88868356 |
| 21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.71977399 |
| 22 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.67603611 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.57809378 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.57593333 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.48278522 |
| 26 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.48134150 |
| 27 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.42613578 |
| 28 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.35738161 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.30863767 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27589577 |
| 31 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.20246135 |
| 32 | Sulfur relay system_Homo sapiens_hsa04122 | 1.18148350 |
| 33 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.07598440 |
| 34 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.04518743 |
| 35 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.03207028 |
| 36 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.01894082 |
| 37 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.98492277 |
| 38 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.97082197 |
| 39 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.96530696 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.95916764 |
| 41 | Phototransduction_Homo sapiens_hsa04744 | 0.90818551 |
| 42 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.88145638 |
| 43 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.87727657 |
| 44 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.86839684 |
| 45 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.81144759 |
| 46 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.80222249 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.80094005 |
| 48 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.79276239 |
| 49 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.78769320 |
| 50 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.76541629 |
| 51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75071050 |
| 52 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.74438277 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.73794963 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.69725462 |
| 55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.67807486 |
| 56 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.67678721 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.67077885 |
| 58 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.66040076 |
| 59 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.63309625 |
| 60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.62012231 |
| 61 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.61782561 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.61686023 |
| 63 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.60782962 |
| 64 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.59346172 |
| 65 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59160824 |
| 66 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.58112508 |
| 67 | Carbon metabolism_Homo sapiens_hsa01200 | 0.57620161 |
| 68 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.57352908 |
| 69 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.56760078 |
| 70 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56037601 |
| 71 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.55613270 |
| 72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.54602144 |
| 73 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.53159219 |
| 74 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.52780393 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.48108795 |
| 76 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.47105521 |
| 77 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45864070 |
| 78 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.43560427 |
| 79 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.42999260 |
| 80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.42648082 |
| 81 | Olfactory transduction_Homo sapiens_hsa04740 | 0.42573974 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.42387253 |
| 83 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.42199451 |
| 84 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.40847391 |
| 85 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.37117029 |
| 86 | Thyroid cancer_Homo sapiens_hsa05216 | 0.36317392 |
| 87 | Nicotine addiction_Homo sapiens_hsa05033 | 0.36095031 |
| 88 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.36092701 |
| 89 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35793109 |
| 90 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.35267687 |
| 91 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.34424002 |
| 92 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.34324304 |
| 93 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.33310098 |
| 94 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.30696265 |
| 95 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.27849697 |
| 96 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.27038542 |
| 97 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.26891091 |
| 98 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.25773518 |
| 99 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.25565950 |
| 100 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.25065256 |
| 101 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.25048641 |
| 102 | Alcoholism_Homo sapiens_hsa05034 | 0.24656738 |
| 103 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.23470248 |
| 104 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.22205027 |
| 105 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.21783886 |
| 106 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.20332460 |
| 107 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.18433943 |
| 108 | Histidine metabolism_Homo sapiens_hsa00340 | 0.16681129 |
| 109 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.16526526 |
| 110 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.14970345 |
| 111 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.13981172 |
| 112 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.13884948 |
| 113 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.13803671 |
| 114 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.13301102 |
| 115 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.11372012 |
| 116 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.10139695 |

