ENY2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.46231381
2DNA deamination (GO:0045006)5.39681593
3ribosomal small subunit assembly (GO:0000028)5.24623445
4viral transcription (GO:0019083)4.80970385
5ribosomal small subunit biogenesis (GO:0042274)4.80410657
6translational termination (GO:0006415)4.74794335
7proteasome assembly (GO:0043248)4.70870130
8CENP-A containing nucleosome assembly (GO:0034080)4.67405407
9chromatin remodeling at centromere (GO:0031055)4.56623163
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.55304892
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.50616925
12cotranslational protein targeting to membrane (GO:0006613)4.49849604
13ribosomal large subunit biogenesis (GO:0042273)4.46362103
14protein targeting to ER (GO:0045047)4.42925720
15kinetochore assembly (GO:0051382)4.31909634
16kinetochore organization (GO:0051383)4.30930510
17protein localization to endoplasmic reticulum (GO:0070972)4.24212905
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.17207941
19mitotic metaphase plate congression (GO:0007080)4.16577126
20translational elongation (GO:0006414)4.12892407
21ATP synthesis coupled proton transport (GO:0015986)4.11089552
22energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11089552
23chaperone-mediated protein transport (GO:0072321)4.03353040
24maturation of SSU-rRNA (GO:0030490)4.01190650
25deoxyribose phosphate biosynthetic process (GO:0046385)3.88644577
262-deoxyribonucleotide biosynthetic process (GO:0009265)3.88644577
27translational initiation (GO:0006413)3.87806971
28DNA replication-independent nucleosome assembly (GO:0006336)3.84735313
29DNA replication-independent nucleosome organization (GO:0034724)3.84735313
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.82027506
31termination of RNA polymerase III transcription (GO:0006386)3.82027506
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.79800847
33cellular protein complex disassembly (GO:0043624)3.76603487
34translation (GO:0006412)3.75073938
35deoxyribonucleotide biosynthetic process (GO:0009263)3.74580157
36DNA replication checkpoint (GO:0000076)3.69520827
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.68280074
38protein deneddylation (GO:0000338)3.68150365
39spliceosomal snRNP assembly (GO:0000387)3.67837451
40viral life cycle (GO:0019058)3.67456239
41metaphase plate congression (GO:0051310)3.67248041
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67196142
43telomere maintenance via semi-conservative replication (GO:0032201)3.67124832
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.65167717
45ribonucleoprotein complex biogenesis (GO:0022613)3.63696047
46histone exchange (GO:0043486)3.63392044
47regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62939159
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59041449
49cullin deneddylation (GO:0010388)3.58249397
50DNA damage response, detection of DNA damage (GO:0042769)3.57885653
51respiratory chain complex IV assembly (GO:0008535)3.56239601
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56228241
53mitochondrial respiratory chain complex I assembly (GO:0032981)3.56228241
54NADH dehydrogenase complex assembly (GO:0010257)3.56228241
55spliceosomal complex assembly (GO:0000245)3.54853216
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54317007
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53104522
587-methylguanosine mRNA capping (GO:0006370)3.53052409
597-methylguanosine RNA capping (GO:0009452)3.52256122
60RNA capping (GO:0036260)3.52256122
61establishment of integrated proviral latency (GO:0075713)3.49598567
62nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48534906
63protein complex biogenesis (GO:0070271)3.47579332
64maturation of 5.8S rRNA (GO:0000460)3.47529959
65DNA strand elongation involved in DNA replication (GO:0006271)3.47512858
66rRNA modification (GO:0000154)3.46576833
67regulation of mitochondrial translation (GO:0070129)3.41967057
68negative regulation of ligase activity (GO:0051352)3.41164398
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.41164398
70cellular component biogenesis (GO:0044085)3.39524898
71telomere maintenance via recombination (GO:0000722)3.38617084
72respiratory electron transport chain (GO:0022904)3.38307879
73rRNA processing (GO:0006364)3.34951885
74protein localization to mitochondrion (GO:0070585)3.34469710
75establishment of protein localization to mitochondrion (GO:0072655)3.34003969
76inner mitochondrial membrane organization (GO:0007007)3.32833670
77L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.32192976
78attachment of spindle microtubules to kinetochore (GO:0008608)3.31957964
79cytochrome complex assembly (GO:0017004)3.31886023
80histone mRNA metabolic process (GO:0008334)3.30194356
81DNA strand elongation (GO:0022616)3.30169374
82purine nucleobase biosynthetic process (GO:0009113)3.29375053
83regulation of cellular amino acid metabolic process (GO:0006521)3.29336784
84ATP biosynthetic process (GO:0006754)3.28631794
85regulation of mitotic spindle checkpoint (GO:1903504)3.27045827
86regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.27045827
87electron transport chain (GO:0022900)3.26981580
88mitochondrial respiratory chain complex assembly (GO:0033108)3.26130344
89establishment of chromosome localization (GO:0051303)3.24683482
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.22107225
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22107225
92protein complex disassembly (GO:0043241)3.21833941
93signal transduction involved in cell cycle checkpoint (GO:0072395)3.21740521
94protein neddylation (GO:0045116)3.20579130
95purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19057107
96rRNA metabolic process (GO:0016072)3.18848228
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.18739625
98DNA double-strand break processing (GO:0000729)3.18039474
99hydrogen ion transmembrane transport (GO:1902600)3.17820317
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.17415860
101pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.17088607
102mitotic recombination (GO:0006312)3.15897796
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.15141997
104GTP biosynthetic process (GO:0006183)3.14579125
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14035327
106macromolecular complex disassembly (GO:0032984)3.11961290
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11779787
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11779787
109sequestering of actin monomers (GO:0042989)3.11710801
110ribosome assembly (GO:0042255)3.10668700
111transcription-coupled nucleotide-excision repair (GO:0006283)3.09915158
112nucleobase biosynthetic process (GO:0046112)3.09712589
113protein targeting to mitochondrion (GO:0006626)3.09051478
114positive regulation of ligase activity (GO:0051351)3.08676512
115signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.08652063
116signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.08652063
117signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.08652063
118pseudouridine synthesis (GO:0001522)3.07033362
119water-soluble vitamin biosynthetic process (GO:0042364)3.06945455
120DNA replication initiation (GO:0006270)3.06628082
121regulation of helicase activity (GO:0051095)2.98280971
122tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.96135452
123RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.96135452
124replication fork processing (GO:0031297)2.93035703
125intracellular protein transmembrane import (GO:0044743)2.91891032
126regulation of ubiquitin-protein transferase activity (GO:0051438)2.89567644

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08847926
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.98957775
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.55479573
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.30107280
5* EST1_17652178_ChIP-ChIP_JURKAT_Human4.05034674
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65955663
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.56756830
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52455863
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.42751798
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.40186296
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.37954193
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.33596132
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24120951
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.96063560
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95876078
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.91897859
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82355119
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.75776741
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.73239899
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70824035
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67654811
22VDR_23849224_ChIP-Seq_CD4+_Human2.56351576
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.49969095
24XRN2_22483619_ChIP-Seq_HELA_Human2.46809531
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.46334762
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46223157
27ELK1_19687146_ChIP-ChIP_HELA_Human2.38499261
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37041899
29AR_21909140_ChIP-Seq_LNCAP_Human2.23773387
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21248292
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.17017561
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15328148
33TTF2_22483619_ChIP-Seq_HELA_Human2.14288509
34* FOXP3_21729870_ChIP-Seq_TREG_Human2.13740038
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12962067
36* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12798738
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03953613
38GABP_19822575_ChIP-Seq_HepG2_Human2.03842293
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02852835
40* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.00779349
41ZNF274_21170338_ChIP-Seq_K562_Hela1.90720928
42VDR_22108803_ChIP-Seq_LS180_Human1.88555106
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88285789
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84271230
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82908172
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70237722
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66027120
48MYC_18940864_ChIP-ChIP_HL60_Human1.64836570
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61994502
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59641289
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.56938411
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.55500255
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53059420
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.52641420
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49875290
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45944366
57* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43345861
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40175525
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38860993
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.38381153
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37740243
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37231000
63* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35898266
64IGF1R_20145208_ChIP-Seq_DFB_Human1.34093737
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29137397
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28763667
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25987664
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24224638
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.24010415
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22825061
71ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19389489
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18000047
73* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13291130
74KDM5A_27292631_Chip-Seq_BREAST_Human1.11958055
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11882978
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08544632
77P300_19829295_ChIP-Seq_ESCs_Human1.07395636
78SOX17_20123909_ChIP-Seq_XEN_Mouse1.07178524
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06764300
80IRF1_19129219_ChIP-ChIP_H3396_Human1.06279490
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06177971
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.05158509
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05068425
84TAF15_26573619_Chip-Seq_HEK293_Human1.04199800
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.02152221
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00762112
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00660786
88* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00367821
89TP53_22573176_ChIP-Seq_HFKS_Human0.99657129
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99378475
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99292961
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99282746
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97104649
94EWS_26573619_Chip-Seq_HEK293_Human0.97037772
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96705306
96PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96353157
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95751557
98* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95587898
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94866845
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94090813
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92266737
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89464116
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88604198
104FUS_26573619_Chip-Seq_HEK293_Human0.87285878
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.83793129
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.83652502
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82023047
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81080538
109ER_23166858_ChIP-Seq_MCF-7_Human0.79349580
110NANOG_19829295_ChIP-Seq_ESCs_Human0.76575113
111SOX2_19829295_ChIP-Seq_ESCs_Human0.76575113
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76221883
113* AR_20517297_ChIP-Seq_VCAP_Human0.73533515
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.73232241
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72863388
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72542194
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71821674
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.71634706
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70165232
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.68941130
121CIITA_25753668_ChIP-Seq_RAJI_Human0.67536841
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.67067635
123CTCF_18555785_ChIP-Seq_MESCs_Mouse0.66970242
124* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64301417
125NANOG_16153702_ChIP-ChIP_HESCs_Human0.63003604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.79248603
2MP0009379_abnormal_foot_pigmentation4.17777215
3MP0004957_abnormal_blastocyst_morpholog3.74486337
4MP0001529_abnormal_vocalization2.97370446
5MP0003077_abnormal_cell_cycle2.93007924
6MP0003123_paternal_imprinting2.86951891
7MP0010094_abnormal_chromosome_stability2.85918993
8MP0003315_abnormal_perineum_morphology2.79478505
9MP0009697_abnormal_copulation2.79232595
10MP0008932_abnormal_embryonic_tissue2.76624927
11MP0003718_maternal_effect2.73552014
12MP0003111_abnormal_nucleus_morphology2.65618576
13MP0003806_abnormal_nucleotide_metabolis2.58800632
14MP0005408_hypopigmentation2.49982295
15MP0006292_abnormal_olfactory_placode2.42041273
16MP0002102_abnormal_ear_morphology2.34629974
17MP0008007_abnormal_cellular_replicative2.24487239
18MP0003186_abnormal_redox_activity2.12560196
19MP0002139_abnormal_hepatobiliary_system2.09813102
20MP0008058_abnormal_DNA_repair2.04091283
21MP0003136_yellow_coat_color1.84354216
22MP0004147_increased_porphyrin_level1.79932085
23MP0002938_white_spotting1.79680935
24MP0009053_abnormal_anal_canal1.72748892
25MP0000372_irregular_coat_pigmentation1.72607085
26MP0010030_abnormal_orbit_morphology1.71289338
27MP0002160_abnormal_reproductive_system1.66515965
28MP0008789_abnormal_olfactory_epithelium1.63732793
29MP0005085_abnormal_gallbladder_physiolo1.61934033
30MP0005360_urolithiasis1.58102343
31MP0003786_premature_aging1.55512573
32MP0003121_genomic_imprinting1.53197791
33MP0004142_abnormal_muscle_tone1.48408382
34MP0000566_synostosis1.46509743
35MP0008057_abnormal_DNA_replication1.45654900
36MP0002837_dystrophic_cardiac_calcinosis1.44771892
37MP0003195_calcinosis1.42478178
38MP0006036_abnormal_mitochondrial_physio1.42073976
39MP0002736_abnormal_nociception_after1.41795278
40MP0005389_reproductive_system_phenotype1.40488113
41MP0008995_early_reproductive_senescence1.39969219
42MP0006054_spinal_hemorrhage1.38248414
43MP0003656_abnormal_erythrocyte_physiolo1.35801311
44MP0002751_abnormal_autonomic_nervous1.31981407
45MP0005253_abnormal_eye_physiology1.31274866
46MP0004133_heterotaxia1.30928663
47MP0005084_abnormal_gallbladder_morpholo1.30441911
48MP0000049_abnormal_middle_ear1.30004156
49MP0008877_abnormal_DNA_methylation1.28375045
50MP0003941_abnormal_skin_development1.26998650
51MP0002234_abnormal_pharynx_morphology1.25809759
52MP0000490_abnormal_crypts_of1.25644245
53MP0001188_hyperpigmentation1.24608601
54MP0003011_delayed_dark_adaptation1.23513582
55MP0005220_abnormal_exocrine_pancreas1.23182914
56MP0005551_abnormal_eye_electrophysiolog1.23007672
57MP0001119_abnormal_female_reproductive1.21875500
58MP0003937_abnormal_limbs/digits/tail_de1.20466677
59MP0005646_abnormal_pituitary_gland1.18363294
60MP0002638_abnormal_pupillary_reflex1.17934416
61MP0001730_embryonic_growth_arrest1.17603571
62MP0002277_abnormal_respiratory_mucosa1.14998052
63MP0000350_abnormal_cell_proliferation1.14889694
64MP0009250_abnormal_appendicular_skeleto1.14604063
65MP0002163_abnormal_gland_morphology1.13517988
66MP0003880_abnormal_central_pattern1.10033589
67MP0006035_abnormal_mitochondrial_morpho1.07695469
68MP0002138_abnormal_hepatobiliary_system1.07062842
69MP0000647_abnormal_sebaceous_gland1.05190650
70MP0002210_abnormal_sex_determination1.05186243
71MP0001764_abnormal_homeostasis1.05170990
72MP0002396_abnormal_hematopoietic_system1.01788473
73MP0005636_abnormal_mineral_homeostasis0.98997533
74MP0008872_abnormal_physiological_respon0.98974520
75MP0001697_abnormal_embryo_size0.98739246
76MP0002132_abnormal_respiratory_system0.98559338
77MP0000653_abnormal_sex_gland0.97021889
78MP0003942_abnormal_urinary_system0.95345116
79MP0002653_abnormal_ependyma_morphology0.94633184
80MP0005365_abnormal_bile_salt0.94586472
81MP0002282_abnormal_trachea_morphology0.94490010
82MP0003938_abnormal_ear_development0.93647907
83MP0001919_abnormal_reproductive_system0.93275113
84MP0008875_abnormal_xenobiotic_pharmacok0.91427480
85MP0001968_abnormal_touch/_nociception0.90752830
86MP0005394_taste/olfaction_phenotype0.90526196
87MP0005499_abnormal_olfactory_system0.90526196
88MP0001145_abnormal_male_reproductive0.89957942
89MP0003890_abnormal_embryonic-extraembry0.89372177
90MP0005391_vision/eye_phenotype0.88852759
91MP0005503_abnormal_tendon_morphology0.88665023
92MP0002233_abnormal_nose_morphology0.88457970
93MP0001984_abnormal_olfaction0.86017140
94MP0009046_muscle_twitch0.84562246
95MP0001286_abnormal_eye_development0.83963024
96MP0005195_abnormal_posterior_eye0.83447380
97MP0003787_abnormal_imprinting0.83251357
98MP0000313_abnormal_cell_death0.82242658
99MP0001672_abnormal_embryogenesis/_devel0.81676680
100MP0005380_embryogenesis_phenotype0.81676680
101MP0002085_abnormal_embryonic_tissue0.81551902
102MP0003385_abnormal_body_wall0.80986467
103MP0002080_prenatal_lethality0.79985018
104MP0005379_endocrine/exocrine_gland_phen0.79874405
105MP0001929_abnormal_gametogenesis0.79739766
106MP0003698_abnormal_male_reproductive0.79095956
107MP0005075_abnormal_melanosome_morpholog0.77530009
108MP0004145_abnormal_muscle_electrophysio0.77463389
109MP0005187_abnormal_penis_morphology0.77459543
110MP0001905_abnormal_dopamine_level0.76303066
111MP0005395_other_phenotype0.75969157
112MP0000631_abnormal_neuroendocrine_gland0.75460363
113MP0001485_abnormal_pinna_reflex0.74334713
114MP0004215_abnormal_myocardial_fiber0.73650657
115MP0002697_abnormal_eye_size0.73611949
116MP0002090_abnormal_vision0.72934125
117MP0003567_abnormal_fetal_cardiomyocyte0.71982205
118MP0000613_abnormal_salivary_gland0.71410139
119MP0005410_abnormal_fertilization0.70309613
120MP0003122_maternal_imprinting0.69417179
121MP0003868_abnormal_feces_composition0.69060397
122MP0003119_abnormal_digestive_system0.69012693
123MP0003984_embryonic_growth_retardation0.68247922
124MP0003755_abnormal_palate_morphology0.68057302
125MP0006072_abnormal_retinal_apoptosis0.67214152
126MP0002095_abnormal_skin_pigmentation0.66823204
127MP0008004_abnormal_stomach_pH0.65172331
128MP0003699_abnormal_female_reproductive0.64977517
129MP0002088_abnormal_embryonic_growth/wei0.64666531
130MP0006276_abnormal_autonomic_nervous0.63833894
131MP0009672_abnormal_birth_weight0.63135395
132MP0001293_anophthalmia0.61261566

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.94586730
2Abnormal mitochondria in muscle tissue (HP:0008316)4.66037456
3Mitochondrial inheritance (HP:0001427)4.41569524
4Abnormality of cells of the erythroid lineage (HP:0012130)4.33483583
5Acute encephalopathy (HP:0006846)4.21423394
6Abnormal number of erythroid precursors (HP:0012131)4.17592100
7Reticulocytopenia (HP:0001896)4.15232217
8Progressive macrocephaly (HP:0004481)4.09608597
9Increased hepatocellular lipid droplets (HP:0006565)4.04030139
10Increased CSF lactate (HP:0002490)3.96961921
11Birth length less than 3rd percentile (HP:0003561)3.95305954
12Hepatocellular necrosis (HP:0001404)3.89239213
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.79618565
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.79618565
15Aplastic anemia (HP:0001915)3.72201883
16Hepatic necrosis (HP:0002605)3.67968404
17Lipid accumulation in hepatocytes (HP:0006561)3.65240212
18Oral leukoplakia (HP:0002745)3.64261158
19Macrocytic anemia (HP:0001972)3.28037349
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.24998398
21Breast hypoplasia (HP:0003187)3.24719350
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.24719331
23Increased serum lactate (HP:0002151)3.15400057
24Cerebral edema (HP:0002181)3.10556415
25Increased intramyocellular lipid droplets (HP:0012240)3.08204906
26Renal Fanconi syndrome (HP:0001994)3.06160173
27Exertional dyspnea (HP:0002875)3.05726484
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98657511
29Pallor (HP:0000980)2.92437321
303-Methylglutaconic aciduria (HP:0003535)2.87700286
31Abnormality of the labia minora (HP:0012880)2.84254247
32Abnormality of glycolysis (HP:0004366)2.73632689
33Increased serum pyruvate (HP:0003542)2.73632689
34Lactic acidosis (HP:0003128)2.72111031
35Abnormality of midbrain morphology (HP:0002418)2.67415283
36Molar tooth sign on MRI (HP:0002419)2.67415283
37Exercise intolerance (HP:0003546)2.67398548
38Methylmalonic acidemia (HP:0002912)2.50261277
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49711943
40Increased muscle lipid content (HP:0009058)2.49538444
41Irregular epiphyses (HP:0010582)2.49452160
42Respiratory failure (HP:0002878)2.46880808
43Patellar aplasia (HP:0006443)2.44900715
44Rough bone trabeculation (HP:0100670)2.43469926
45Medial flaring of the eyebrow (HP:0010747)2.41304971
46Respiratory difficulties (HP:0002880)2.38622139
47Aplasia/Hypoplasia of the patella (HP:0006498)2.33728686
48Nephronophthisis (HP:0000090)2.33618067
49Leukodystrophy (HP:0002415)2.30792495
50Optic disc pallor (HP:0000543)2.30523584
51Secondary amenorrhea (HP:0000869)2.29139649
52Type I transferrin isoform profile (HP:0003642)2.28235539
53Abnormality of urine glucose concentration (HP:0011016)2.28082092
54Glycosuria (HP:0003076)2.28082092
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.26367977
56Septo-optic dysplasia (HP:0100842)2.24421446
57Carpal bone hypoplasia (HP:0001498)2.21449750
58Abnormal lung lobation (HP:0002101)2.20889735
59Capillary hemangiomas (HP:0005306)2.20552104
60Pendular nystagmus (HP:0012043)2.18293307
61Microretrognathia (HP:0000308)2.17823867
62Horseshoe kidney (HP:0000085)2.16145558
63Methylmalonic aciduria (HP:0012120)2.13933811
64Pancreatic cysts (HP:0001737)2.13136761
65Hyperglycinemia (HP:0002154)2.12278437
66Cerebral hypomyelination (HP:0006808)2.10400302
67Abnormal hemoglobin (HP:0011902)2.09165085
68Lethargy (HP:0001254)2.07911437
69Hyperphosphaturia (HP:0003109)2.07369383
70Abnormality of renal resorption (HP:0011038)2.04338813
71Abnormality of chromosome stability (HP:0003220)2.04162175
72Chromsome breakage (HP:0040012)2.02305776
73Abnormality of serum amino acid levels (HP:0003112)2.00606575
74Abnormality of the anterior horn cell (HP:0006802)1.99683130
75Degeneration of anterior horn cells (HP:0002398)1.99683130
7611 pairs of ribs (HP:0000878)1.99142127
77Microvesicular hepatic steatosis (HP:0001414)1.98313291
78Absent septum pellucidum (HP:0001331)1.98170993
79Triphalangeal thumb (HP:0001199)1.98050565
80Hypobetalipoproteinemia (HP:0003563)1.96324893
81Supernumerary spleens (HP:0009799)1.95045413
82Colon cancer (HP:0003003)1.94609609
83Abnormality of the pons (HP:0007361)1.94010715
84Premature graying of hair (HP:0002216)1.93585091
85Facial hemangioma (HP:0000329)1.92857794
86Amniotic constriction ring (HP:0009775)1.92813869
87Abnormality of placental membranes (HP:0011409)1.92813869
88Bifid tongue (HP:0010297)1.92233714
89Sclerocornea (HP:0000647)1.90826651
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90772506
91Abnormal protein N-linked glycosylation (HP:0012347)1.90772506
92Abnormal protein glycosylation (HP:0012346)1.90772506
93Abnormal glycosylation (HP:0012345)1.90772506
94Congenital primary aphakia (HP:0007707)1.89342401
95Abnormality of aromatic amino acid family metabolism (HP:0004338)1.89291063
96Meckel diverticulum (HP:0002245)1.88534959
97Hypoplasia of the pons (HP:0012110)1.87004420
98Congenital, generalized hypertrichosis (HP:0004540)1.86199088
99Abnormal trabecular bone morphology (HP:0100671)1.85150004
100Reduced antithrombin III activity (HP:0001976)1.84602501
101Stenosis of the external auditory canal (HP:0000402)1.83162364
102Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83065617
103Abnormality of the renal medulla (HP:0100957)1.82366221
104Nephrogenic diabetes insipidus (HP:0009806)1.82045787
105Flat capital femoral epiphysis (HP:0003370)1.81413083
106X-linked dominant inheritance (HP:0001423)1.81383958
107Abnormality of alanine metabolism (HP:0010916)1.80509950
108Hyperalaninemia (HP:0003348)1.80509950
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80509950
110CNS demyelination (HP:0007305)1.80333794
111Abnormality of the septum pellucidum (HP:0007375)1.79935814
112Aplasia/hypoplasia of the uterus (HP:0008684)1.79527332
113Adrenal hypoplasia (HP:0000835)1.79513258
114Redundant skin (HP:0001582)1.79193929
115Cleft eyelid (HP:0000625)1.79056036
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78556613
117Abnormality of the preputium (HP:0100587)1.77949303
118Gait imbalance (HP:0002141)1.77747406
119Abnormality of methionine metabolism (HP:0010901)1.77665481
120Absent thumb (HP:0009777)1.77076514
121Abnormality of the ileum (HP:0001549)1.75176965
122Self-mutilation (HP:0000742)1.74479223
123Pancreatic fibrosis (HP:0100732)1.72731262
124Pancytopenia (HP:0001876)1.72223733
125Median cleft lip (HP:0000161)1.72089965
126Absent radius (HP:0003974)1.71645074
127Unsteady gait (HP:0002317)1.71106377
128Nephroblastoma (Wilms tumor) (HP:0002667)1.70896805
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.70465513
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70433358
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68334696
132Embryonal renal neoplasm (HP:0011794)1.68203612
133Genital tract atresia (HP:0001827)1.67722243
134Diastasis recti (HP:0001540)1.67187420
135True hermaphroditism (HP:0010459)1.66866522
136Bilateral microphthalmos (HP:0007633)1.66611370
137Hypothermia (HP:0002045)1.65867607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.35722922
2BUB14.23966208
3STK163.63339524
4EIF2AK13.57788613
5NME23.29627657
6SRPK13.08438402
7WEE12.82518267
8CDC72.69479121
9ACVR1B2.60835586
10VRK12.58172577
11PLK42.47940794
12CDK82.07184229
13EIF2AK31.99784541
14BRSK21.96908459
15TESK21.95554022
16NME11.95369320
17TLK11.92126252
18MAP4K21.80576812
19TRIM281.75399148
20PBK1.73916511
21BRAF1.72154396
22TAF11.67601095
23PLK11.64208573
24CCNB11.64011026
25BMPR1B1.63509932
26NEK11.61405369
27BRSK11.57442080
28PIM21.56155258
29MKNK11.54210344
30STK38L1.52458206
31TTK1.51434202
32DYRK21.46108810
33AURKB1.41716972
34PNCK1.38522130
35PLK31.36981991
36PINK11.36414715
37MAP3K41.32922190
38DYRK31.29004113
39LIMK11.27830441
40AURKA1.25592698
41MST41.24998002
42MKNK21.21205988
43ARAF1.16930976
44ZAK1.16818640
45TESK11.14498777
46ABL21.11724352
47ADRBK21.11299948
48MELK1.10571412
49NUAK11.04452638
50TGFBR11.04300400
51ERBB31.01556288
52MUSK1.01246461
53GRK11.01033164
54TNIK1.00122739
55MAP3K120.98804979
56MAP3K60.97464848
57NEK20.94045536
58LATS20.90878610
59BCKDK0.90144059
60CDK70.89844554
61EIF2AK20.87472528
62CHEK20.87119768
63ERBB40.83367111
64FRK0.81098859
65ATR0.80649015
66INSRR0.79888642
67ILK0.77947581
68MAP2K70.75897226
69NEK90.75639858
70CSNK2A10.75207885
71MAPK130.74256388
72RAF10.70790781
73RPS6KA40.67402780
74PDK20.66352117
75KDR0.62292370
76RPS6KB20.61924336
77CSNK1G30.60517544
78BCR0.59806671
79TIE10.58809118
80CSNK1A1L0.58498564
81CSNK2A20.57344365
82CSNK1G10.57038442
83NEK60.56041427
84CHEK10.55138970
85PLK20.54832095
86OXSR10.54590204
87PRKCG0.52658873
88CDK30.50093689
89MARK10.49796255
90MAPKAPK50.46245248
91MOS0.45782425
92MAP3K80.45764587
93STK30.44758927
94ATM0.42507164
95CSNK1E0.42249713
96CDK190.41993510
97PASK0.41795018
98PAK10.38758836
99NLK0.38502649
100TSSK60.37427069
101STK40.37062812
102MYLK0.35706031
103CDK10.35579553
104CDK20.35505996
105PRKCE0.34541106
106MAP3K110.34067243
107MINK10.33637223
108CSNK1A10.33569833
109YES10.32913089
110PRKCI0.31731604
111EPHB20.31711442
112STK390.31671015
113FLT30.30318183
114MAPK150.30238546
115WNK40.29870828
116PIK3CG0.29707262
117IRAK30.29654942
118WNK30.29319413
119GRK70.29241860
120DAPK10.28698952
121KSR10.28595836
122TEC0.28412271
123ADRBK10.27080778
124TBK10.27029029
125CSNK1G20.26544854
126CDK140.25701294
127CDK180.25574242
128RPS6KA50.24097992
129BMPR20.22789113
130CASK0.21447071
131CDK11A0.21352335

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.75178829
2Proteasome_Homo sapiens_hsa030503.93120851
3RNA polymerase_Homo sapiens_hsa030203.70899033
4DNA replication_Homo sapiens_hsa030303.60004136
5Protein export_Homo sapiens_hsa030603.26081511
6Oxidative phosphorylation_Homo sapiens_hsa001902.92625870
7Mismatch repair_Homo sapiens_hsa034302.74821614
8Spliceosome_Homo sapiens_hsa030402.71607541
9Parkinsons disease_Homo sapiens_hsa050122.71473754
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69313129
11Pyrimidine metabolism_Homo sapiens_hsa002402.65206666
12Homologous recombination_Homo sapiens_hsa034402.53996985
13Nucleotide excision repair_Homo sapiens_hsa034202.19258179
14Huntingtons disease_Homo sapiens_hsa050162.17117952
15RNA transport_Homo sapiens_hsa030132.14499463
16Base excision repair_Homo sapiens_hsa034102.02900887
17Cell cycle_Homo sapiens_hsa041101.99380463
18RNA degradation_Homo sapiens_hsa030181.93833387
19Basal transcription factors_Homo sapiens_hsa030221.92510613
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88868356
21Alzheimers disease_Homo sapiens_hsa050101.71977399
22One carbon pool by folate_Homo sapiens_hsa006701.67603611
23Fanconi anemia pathway_Homo sapiens_hsa034601.57809378
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57593333
25Purine metabolism_Homo sapiens_hsa002301.48278522
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48134150
27Folate biosynthesis_Homo sapiens_hsa007901.42613578
28Non-homologous end-joining_Homo sapiens_hsa034501.35738161
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.30863767
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27589577
31Glutathione metabolism_Homo sapiens_hsa004801.20246135
32Sulfur relay system_Homo sapiens_hsa041221.18148350
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.07598440
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04518743
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03207028
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01894082
37Sulfur metabolism_Homo sapiens_hsa009200.98492277
38p53 signaling pathway_Homo sapiens_hsa041150.97082197
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96530696
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95916764
41Phototransduction_Homo sapiens_hsa047440.90818551
42mRNA surveillance pathway_Homo sapiens_hsa030150.88145638
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87727657
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86839684
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81144759
46Systemic lupus erythematosus_Homo sapiens_hsa053220.80222249
47Steroid biosynthesis_Homo sapiens_hsa001000.80094005
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79276239
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.78769320
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76541629
51Metabolic pathways_Homo sapiens_hsa011000.75071050
52Pyruvate metabolism_Homo sapiens_hsa006200.74438277
53Selenocompound metabolism_Homo sapiens_hsa004500.73794963
54Peroxisome_Homo sapiens_hsa041460.69725462
55Epstein-Barr virus infection_Homo sapiens_hsa051690.67807486
56Chemical carcinogenesis_Homo sapiens_hsa052040.67678721
57Cardiac muscle contraction_Homo sapiens_hsa042600.67077885
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66040076
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.63309625
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62012231
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.61782561
62Caffeine metabolism_Homo sapiens_hsa002320.61686023
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60782962
64Collecting duct acid secretion_Homo sapiens_hsa049660.59346172
65Nitrogen metabolism_Homo sapiens_hsa009100.59160824
66N-Glycan biosynthesis_Homo sapiens_hsa005100.58112508
67Carbon metabolism_Homo sapiens_hsa012000.57620161
68Biosynthesis of amino acids_Homo sapiens_hsa012300.57352908
69Oocyte meiosis_Homo sapiens_hsa041140.56760078
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.56037601
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55613270
72Pentose phosphate pathway_Homo sapiens_hsa000300.54602144
73Propanoate metabolism_Homo sapiens_hsa006400.53159219
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52780393
75Arginine and proline metabolism_Homo sapiens_hsa003300.48108795
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47105521
77Vitamin B6 metabolism_Homo sapiens_hsa007500.45864070
78Vitamin digestion and absorption_Homo sapiens_hsa049770.43560427
79Tyrosine metabolism_Homo sapiens_hsa003500.42999260
80Tryptophan metabolism_Homo sapiens_hsa003800.42648082
81Olfactory transduction_Homo sapiens_hsa047400.42573974
82Retinol metabolism_Homo sapiens_hsa008300.42387253
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42199451
84Arachidonic acid metabolism_Homo sapiens_hsa005900.40847391
85Regulation of autophagy_Homo sapiens_hsa041400.37117029
86Thyroid cancer_Homo sapiens_hsa052160.36317392
87Nicotine addiction_Homo sapiens_hsa050330.36095031
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36092701
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35793109
90Butanoate metabolism_Homo sapiens_hsa006500.35267687
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34424002
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34324304
93Basal cell carcinoma_Homo sapiens_hsa052170.33310098
94Linoleic acid metabolism_Homo sapiens_hsa005910.30696265
95Hedgehog signaling pathway_Homo sapiens_hsa043400.27849697
96beta-Alanine metabolism_Homo sapiens_hsa004100.27038542
97Herpes simplex infection_Homo sapiens_hsa051680.26891091
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25773518
99Phenylalanine metabolism_Homo sapiens_hsa003600.25565950
100TGF-beta signaling pathway_Homo sapiens_hsa043500.25065256
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25048641
102Alcoholism_Homo sapiens_hsa050340.24656738
103Fatty acid degradation_Homo sapiens_hsa000710.23470248
104Fatty acid metabolism_Homo sapiens_hsa012120.22205027
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21783886
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20332460
107Fatty acid elongation_Homo sapiens_hsa000620.18433943
108Histidine metabolism_Homo sapiens_hsa003400.16681129
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16526526
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14970345
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13981172
112Viral carcinogenesis_Homo sapiens_hsa052030.13884948
113Ether lipid metabolism_Homo sapiens_hsa005650.13803671
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13301102
115Starch and sucrose metabolism_Homo sapiens_hsa005000.11372012
116Vibrio cholerae infection_Homo sapiens_hsa051100.10139695

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