EOGT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.06083176
2endothelium development (GO:0003158)6.47098412
3vascular endothelial growth factor signaling pathway (GO:0038084)6.40905753
4positive regulation of vasculogenesis (GO:2001214)5.01630289
5endothelial cell morphogenesis (GO:0001886)4.96844241
6lymphangiogenesis (GO:0001946)4.80277713
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.71045943
8regulation of vasculogenesis (GO:2001212)4.68011121
9peptidyl-tyrosine autophosphorylation (GO:0038083)4.64193597
10vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.53563402
11surfactant homeostasis (GO:0043129)4.52570057
12endodermal cell differentiation (GO:0035987)4.40796511
13melanin biosynthetic process (GO:0042438)4.31633502
14patterning of blood vessels (GO:0001569)4.31457845
15basement membrane organization (GO:0071711)4.30722728
16sprouting angiogenesis (GO:0002040)4.27766509
17retina vasculature morphogenesis in camera-type eye (GO:0061299)4.26432019
18sequestering of extracellular ligand from receptor (GO:0035581)4.17053858
19cell migration involved in sprouting angiogenesis (GO:0002042)4.07590094
20blood vessel endothelial cell migration (GO:0043534)3.95481510
21endothelial cell differentiation (GO:0045446)3.88884867
22melanin metabolic process (GO:0006582)3.88869708
23blood vessel maturation (GO:0001955)3.61041451
24chemical homeostasis within a tissue (GO:0048875)3.59614404
25artery development (GO:0060840)3.49608786
26regulation of endothelial cell differentiation (GO:0045601)3.49273254
27pathway-restricted SMAD protein phosphorylation (GO:0060389)3.41665489
28morphogenesis of an endothelium (GO:0003159)3.37260235
29endothelial tube morphogenesis (GO:0061154)3.37260235
30secondary metabolite biosynthetic process (GO:0044550)3.33391220
31hemidesmosome assembly (GO:0031581)3.26829777
32regulation of transforming growth factor beta2 production (GO:0032909)3.26148400
33negative regulation of nitric oxide biosynthetic process (GO:0045019)3.24534668
34bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20325047
35Notch signaling involved in heart development (GO:0061314)3.17154985
36gap junction assembly (GO:0016264)3.13409732
37coronary vasculature morphogenesis (GO:0060977)3.13275148
38protein localization to endosome (GO:0036010)3.13175662
39hippo signaling (GO:0035329)3.11957975
40wound healing, spreading of cells (GO:0044319)3.11792237
41positive regulation of endothelial cell migration (GO:0010595)3.10553739
42positive regulation of protein autophosphorylation (GO:0031954)3.10277002
43regulation of metalloenzyme activity (GO:0048552)3.10129490
44keratan sulfate catabolic process (GO:0042340)3.05858530
45substrate-dependent cell migration (GO:0006929)3.02964939
46hyaluronan catabolic process (GO:0030214)3.00753126
47regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.99777907
48positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.99627041
49ovulation from ovarian follicle (GO:0001542)2.98444511
50regulation of transforming growth factor beta1 production (GO:0032908)2.98279298
51regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.97433928
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.97012644
53cell adhesion mediated by integrin (GO:0033627)2.96885660
54chondrocyte proliferation (GO:0035988)2.93597424
55renal filtration (GO:0097205)2.93285201
56mRNA transcription (GO:0009299)2.92520922
57neuron projection extension involved in neuron projection guidance (GO:1902284)2.90244306
58axon extension involved in axon guidance (GO:0048846)2.90244306
59positive regulation of chemokine biosynthetic process (GO:0045080)2.88830832
60cellular response to vitamin D (GO:0071305)2.88601593
61pericardium development (GO:0060039)2.87096642
62embryonic heart tube development (GO:0035050)2.86242779
63blood vessel remodeling (GO:0001974)2.84597409
64endothelial cell migration (GO:0043542)2.84502280
65cellular response to vitamin (GO:0071295)2.83201120
66glomerular filtration (GO:0003094)2.82851551
67regulation of axon extension involved in axon guidance (GO:0048841)2.82446154
68vasculogenesis (GO:0001570)2.82433629
69positive regulation of cell junction assembly (GO:1901890)2.80599468
70positive regulation of focal adhesion assembly (GO:0051894)2.80599468
71glomerular visceral epithelial cell development (GO:0072015)2.80195316
72adhesion of symbiont to host (GO:0044406)2.76485470
73Rap protein signal transduction (GO:0032486)2.76437360
74semaphorin-plexin signaling pathway (GO:0071526)2.76071394
75embryonic foregut morphogenesis (GO:0048617)2.75994199
76mRNA transcription from RNA polymerase II promoter (GO:0042789)2.75476721
77blood vessel morphogenesis (GO:0048514)2.73935611
78positive regulation of odontogenesis (GO:0042482)2.73863452
79negative regulation of keratinocyte proliferation (GO:0010839)2.73788645
80response to fluid shear stress (GO:0034405)2.72904804
81protein targeting to plasma membrane (GO:0072661)2.72362031
82regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.72294809
83negative regulation of activin receptor signaling pathway (GO:0032926)2.72055422
84positive regulation of adherens junction organization (GO:1903393)2.71126495
85establishment of endothelial barrier (GO:0061028)2.70075384
86exocrine pancreas development (GO:0031017)2.69907515
87cell migration involved in heart development (GO:0060973)2.68727809
88negative regulation of BMP signaling pathway (GO:0030514)2.68342287
89collagen fibril organization (GO:0030199)2.67722781
90transcytosis (GO:0045056)2.67255144
91regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.66620473
92regulation of cardioblast differentiation (GO:0051890)2.66005563
93negative regulation of vascular permeability (GO:0043116)2.65662965
94regulation of vitamin D biosynthetic process (GO:0060556)2.65395416
95regulation of endothelial cell migration (GO:0010594)2.65375042
96negative regulation of axon extension involved in axon guidance (GO:0048843)2.64829467
97regulation of membrane protein ectodomain proteolysis (GO:0051043)2.64602909
98anterior/posterior axis specification, embryo (GO:0008595)2.62493447
99extracellular regulation of signal transduction (GO:1900115)2.61788475
100extracellular negative regulation of signal transduction (GO:1900116)2.61788475
101decidualization (GO:0046697)2.61330547
102negative regulation of Rho protein signal transduction (GO:0035024)2.61041138
103negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.60576532
104positive regulation of epithelial cell migration (GO:0010634)2.60321803
105endothelial cell proliferation (GO:0001935)2.60055360
106heart trabecula formation (GO:0060347)2.59652244
107smooth muscle tissue development (GO:0048745)2.59613404
108radial glial cell differentiation (GO:0060019)2.58913868
109venous blood vessel morphogenesis (GO:0048845)2.58808554
110substrate adhesion-dependent cell spreading (GO:0034446)2.58571158
111positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.57991623
112collagen metabolic process (GO:0032963)2.57535935
113response to hepatocyte growth factor (GO:0035728)2.55414872
114cellular response to hepatocyte growth factor stimulus (GO:0035729)2.55414872
115lung vasculature development (GO:0060426)2.54918881
116extracellular matrix disassembly (GO:0022617)2.53598010
117activin receptor signaling pathway (GO:0032924)2.53075916
118neural crest cell development (GO:0014032)2.52956672
119protein localization to cell surface (GO:0034394)2.51197604
120collagen catabolic process (GO:0030574)2.51050310
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50041888
122wound healing, spreading of epidermal cells (GO:0035313)2.49277057
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.48898230
124positive regulation of endothelial cell proliferation (GO:0001938)2.48534463
125mesenchymal cell development (GO:0014031)2.48330451
126positive regulation of endothelial cell apoptotic process (GO:2000353)2.48278579
127regulation of establishment of cell polarity (GO:2000114)2.47608348
128cell-substrate junction assembly (GO:0007044)2.47014263
129apoptotic cell clearance (GO:0043277)2.46738626
130membrane raft organization (GO:0031579)2.46537829
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45871476
132regulation of protein autophosphorylation (GO:0031952)2.45782881
133angiogenesis involved in wound healing (GO:0060055)2.45167119
134regulation of establishment or maintenance of cell polarity (GO:0032878)2.44950176
135adherens junction assembly (GO:0034333)2.44775702
136regulation of epithelial cell migration (GO:0010632)2.44688568
137adhesion of symbiont to host cell (GO:0044650)2.43671863
138virion attachment to host cell (GO:0019062)2.43671863
139nodal signaling pathway (GO:0038092)2.43441827
140artery morphogenesis (GO:0048844)2.43108140
141negative regulation of chondrocyte differentiation (GO:0032331)2.42522734
142regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.42105529
143positive regulation of osteoblast proliferation (GO:0033690)2.42098634
144phospholipid scrambling (GO:0017121)2.41519900
145plasma membrane repair (GO:0001778)2.41386556
146L-serine transport (GO:0015825)2.41357875
147skin morphogenesis (GO:0043589)2.40757634
148vitamin transmembrane transport (GO:0035461)2.40749564
149regulation of endothelial cell apoptotic process (GO:2000351)2.40358764
150germ cell migration (GO:0008354)2.40252664
151glomerular epithelial cell development (GO:0072310)2.40010146
152regulation of chemokine biosynthetic process (GO:0045073)2.39126157
153phagocytosis, recognition (GO:0006910)2.38891617
154negative regulation of catenin import into nucleus (GO:0035414)2.38868208
155positive regulation of SMAD protein import into nucleus (GO:0060391)2.37756974
156positive regulation of p38MAPK cascade (GO:1900745)2.37239198
157positive regulation of endothelial cell differentiation (GO:0045603)2.36970732
158regulation of axon guidance (GO:1902667)2.36584485
159mesodermal cell differentiation (GO:0048333)2.36282582
160regulation of mesoderm development (GO:2000380)2.36232886
161lung lobe morphogenesis (GO:0060463)2.36023086
162regulation of integrin-mediated signaling pathway (GO:2001044)2.35847627
163positive regulation of hormone biosynthetic process (GO:0046886)2.35524679
164heart trabecula morphogenesis (GO:0061384)2.35497101
165negative regulation of cell fate specification (GO:0009996)2.34985251
166trabecula morphogenesis (GO:0061383)2.34884550
167layer formation in cerebral cortex (GO:0021819)2.34362525
168ventricular trabecula myocardium morphogenesis (GO:0003222)2.32386266
169cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32047899

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.41321500
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.94758102
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.07832352
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92050485
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85324253
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.76661199
7CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38181157
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36298059
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.28733685
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.24307329
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23999460
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.16211152
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.04137249
14RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97930167
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94831734
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94508729
17CLOCK_20551151_ChIP-Seq_293T_Human1.93166315
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.87614702
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.86501829
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84892244
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76458327
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76458327
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76458327
24AHR_22903824_ChIP-Seq_MCF-7_Human1.75526019
25CJUN_26792858_Chip-Seq_BT549_Human1.73098013
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.70239237
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67243395
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.66650257
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.66254910
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65924715
31FOXO3_23340844_ChIP-Seq_DLD1_Human1.62599307
32PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58430102
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58309243
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56250396
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54694339
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.54082597
37BRD4_25478319_ChIP-Seq_HGPS_Human1.53977307
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.52187916
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51788517
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50218620
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.49203063
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48626636
43TP53_16413492_ChIP-PET_HCT116_Human1.48150410
44TP53_18474530_ChIP-ChIP_U2OS_Human1.44001872
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.43731711
46RXR_22108803_ChIP-Seq_LS180_Human1.43045508
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39954808
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.39814413
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.39269884
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38808152
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38548246
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38548246
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37237089
54SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36870490
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.36337539
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35749381
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35749381
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.35693005
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.35273941
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32285649
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32090621
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31123694
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31034002
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31034002
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.30650956
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.29755318
67SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29668417
68CDX2_22108803_ChIP-Seq_LS180_Human1.28242553
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26887684
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26630436
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26393745
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25120226
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25101446
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24038767
75AR_21572438_ChIP-Seq_LNCaP_Human1.23856651
76SOX2_20726797_ChIP-Seq_SW620_Human1.21553943
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.20568852
78P300_19829295_ChIP-Seq_ESCs_Human1.18125732
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17580996
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.16187631
81TBX20_22080862_ChIP-Seq_HEART_Mouse1.16187631
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15976344
83PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15565072
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15020656
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14433501
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.14425712
87TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13827942
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13717221
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.13160316
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12313693
91VDR_24787735_ChIP-Seq_THP-1_Human1.11706930
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11227255
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07840699
94BCAT_22108803_ChIP-Seq_LS180_Human1.06992972
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06640945
96KDM2B_26808549_Chip-Seq_K562_Human1.05475442
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.05358281
98NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05197074
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.04936197
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03929955
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03817178
102AR_21909140_ChIP-Seq_LNCAP_Human1.03324987
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02782803
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01890156
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00797669
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00649631
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00493658
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99918159
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99635019
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99617658
111JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98654714
112JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98557492
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98313740
114NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98237289
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98156909
116RUNX_20019798_ChIP-Seq_JUKART_Human0.97908950
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97879700
118TP63_23658742_ChIP-Seq_EP156T_Human0.97854522
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97818039
120SMAD3_21741376_ChIP-Seq_HESCs_Human0.97522087
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97342083
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97258909
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96726942
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.96312909
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95999027
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.95996932
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95976183
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.95915285
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95619299
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95493470
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94973657
132SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94795495
133JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94721628
134UBF1/2_26484160_Chip-Seq_HMECs_Human0.94516955
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94355275
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94225880
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93382319
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93147057
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.92525587
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.90446748
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90313041
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89658683
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88582677
144VDR_22108803_ChIP-Seq_LS180_Human0.88211522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.67031242
2MP0001879_abnormal_lymphatic_vessel4.73337512
3MP0004272_abnormal_basement_membrane4.72377750
4MP0005167_abnormal_blood-brain_barrier3.89927052
5MP0005171_absent_coat_pigmentation3.59908506
6MP0003705_abnormal_hypodermis_morpholog3.09679829
7MP0000372_irregular_coat_pigmentation3.03733865
8MP0005623_abnormal_meninges_morphology2.92689115
9MP0003279_aneurysm2.47594200
10MP0003566_abnormal_cell_adhesion2.31756712
11MP0006054_spinal_hemorrhage2.31193444
12MP0008438_abnormal_cutaneous_collagen2.28231256
13MP0002254_reproductive_system_inflammat2.17090866
14MP0003828_pulmonary_edema2.04717301
15MP0006138_congestive_heart_failure2.02010375
16MP0004084_abnormal_cardiac_muscle1.99650688
17MP0003300_gastrointestinal_ulcer1.79337901
18MP0001958_emphysema1.78711599
19MP0003091_abnormal_cell_migration1.78289249
20MP0003890_abnormal_embryonic-extraembry1.77559340
21MP0005408_hypopigmentation1.77330086
22MP0009384_cardiac_valve_regurgitation1.71161555
23MP0000767_abnormal_smooth_muscle1.70732792
24MP0001542_abnormal_bone_strength1.68597412
25MP0004484_altered_response_of1.68111952
26MP0000733_abnormal_muscle_development1.66291541
27MP0005275_abnormal_skin_tensile1.63821859
28MP0010234_abnormal_vibrissa_follicle1.62288184
29MP0002877_abnormal_melanocyte_morpholog1.52961526
30MP0002009_preneoplasia1.49216930
31MP0003195_calcinosis1.47725274
32MP0002925_abnormal_cardiovascular_devel1.47464038
33MP0002295_abnormal_pulmonary_circulatio1.43198185
34MP0005165_increased_susceptibility_to1.40234038
35MP0005367_renal/urinary_system_phenotyp1.37096536
36MP0000516_abnormal_urinary_system1.37096536
37MP0005084_abnormal_gallbladder_morpholo1.36917422
38MP0000013_abnormal_adipose_tissue1.34690671
39MP0002128_abnormal_blood_circulation1.31772465
40MP0010352_gastrointestinal_tract_polyps1.31334324
41MP0008004_abnormal_stomach_pH1.29197883
42MP0005257_abnormal_intraocular_pressure1.27622549
43MP0005248_abnormal_Harderian_gland1.25093767
44MP0001915_intracranial_hemorrhage1.25032196
45MP0000465_gastrointestinal_hemorrhage1.24790666
46MP0005595_abnormal_vascular_smooth1.22111715
47MP0003191_abnormal_cellular_cholesterol1.22008203
48MP0005377_hearing/vestibular/ear_phenot1.17681301
49MP0003878_abnormal_ear_physiology1.17681301
50MP0002998_abnormal_bone_remodeling1.16271030
51MP0010678_abnormal_skin_adnexa1.14982742
52MP0003724_increased_susceptibility_to1.14630586
53MP0001614_abnormal_blood_vessel1.14555658
54MP0003943_abnormal_hepatobiliary_system1.14526973
55MP0001346_abnormal_lacrimal_gland1.13796886
56MP0008775_abnormal_heart_ventricle1.13719743
57MP0005023_abnormal_wound_healing1.13322820
58MP0003941_abnormal_skin_development1.13307111
59MP0002127_abnormal_cardiovascular_syste1.11979915
60MP0005503_abnormal_tendon_morphology1.11946423
61MP0010630_abnormal_cardiac_muscle1.11406314
62MP0002933_joint_inflammation1.10011578
63MP0003045_fibrosis1.08495172
64MP0000569_abnormal_digit_pigmentation1.07497462
65MP0003448_altered_tumor_morphology1.06964439
66MP0000249_abnormal_blood_vessel1.05810246
67MP0002108_abnormal_muscle_morphology1.04959184
68MP0004883_abnormal_blood_vessel1.04443711
69MP0005409_darkened_coat_color1.03991749
70MP0009278_abnormal_bone_marrow1.03230949
71MP0002138_abnormal_hepatobiliary_system1.02918956
72MP0002168_other_aberrant_phenotype1.01888339
73MP0005385_cardiovascular_system_phenoty1.00409709
74MP0001544_abnormal_cardiovascular_syste1.00409709
75MP0003453_abnormal_keratinocyte_physiol0.97879974
76MP0002972_abnormal_cardiac_muscle0.97861258
77MP0000383_abnormal_hair_follicle0.97384640
78MP0003935_abnormal_craniofacial_develop0.97091105
79MP0005164_abnormal_response_to0.95043091
80MP0002896_abnormal_bone_mineralization0.94743145
81MP0002098_abnormal_vibrissa_morphology0.94134628
82MP0001849_ear_inflammation0.94118149
83MP0003303_peritoneal_inflammation0.92874323
84MP0000537_abnormal_urethra_morphology0.92574006
85MP0000371_diluted_coat_color0.91962222
86MP0001533_abnormal_skeleton_physiology0.90994861
87MP0001784_abnormal_fluid_regulation0.89187194
88MP0000751_myopathy0.88720047
89MP0003385_abnormal_body_wall0.88446964
90MP0010030_abnormal_orbit_morphology0.87334219
91MP0004215_abnormal_myocardial_fiber0.87131847
92MP0000266_abnormal_heart_morphology0.87018528
93MP0005330_cardiomyopathy0.86575576
94MP0003950_abnormal_plasma_membrane0.86273659
95MP0002166_altered_tumor_susceptibility0.86133041
96MP0002086_abnormal_extraembryonic_tissu0.85480770
97MP0000749_muscle_degeneration0.84991999
98MP0005508_abnormal_skeleton_morphology0.83014213
99MP0000343_altered_response_to0.82123785
100MP0002133_abnormal_respiratory_system0.82007654
101MP0005388_respiratory_system_phenotype0.82007654
102MP0000377_abnormal_hair_follicle0.81672836
103MP0010386_abnormal_urinary_bladder0.80680902
104MP0004808_abnormal_hematopoietic_stem0.79200630
105MP0005395_other_phenotype0.78258487
106MP0002332_abnormal_exercise_endurance0.78075664
107MP0005390_skeleton_phenotype0.76652758
108MP0005620_abnormal_muscle_contractility0.76591824
109MP0009840_abnormal_foam_cell0.76238304
110MP0009780_abnormal_chondrocyte_physiolo0.76197908
111MP0005197_abnormal_uvea_morphology0.74689663
112MP0000003_abnormal_adipose_tissue0.74473371
113MP0000762_abnormal_tongue_morphology0.73643568
114MP0009697_abnormal_copulation0.73021882
115MP0001243_abnormal_dermal_layer0.72843792
116MP0003795_abnormal_bone_structure0.72474669
117MP0010307_abnormal_tumor_latency0.71983917
118MP0006082_CNS_inflammation0.70079817
119MP0005083_abnormal_biliary_tract0.69684697
120MP0004085_abnormal_heartbeat0.68605050
121MP0003122_maternal_imprinting0.68544699
122MP0001191_abnormal_skin_condition0.67818602
123MP0004510_myositis0.67266960
124MP0002115_abnormal_skeleton_extremities0.66859041
125MP0001216_abnormal_epidermal_layer0.66654831
126MP0004036_abnormal_muscle_relaxation0.66344381
127MP0009250_abnormal_appendicular_skeleto0.65823141
128MP0001661_extended_life_span0.64777445
129MP0002060_abnormal_skin_morphology0.64168360
130MP0005187_abnormal_penis_morphology0.64060766
131MP0002090_abnormal_vision0.63480845
132MP0008007_abnormal_cellular_replicative0.61343510
133MP0000579_abnormal_nail_morphology0.61302884
134MP0002148_abnormal_hypersensitivity_rea0.59951796

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.17056688
2Aortic aneurysm (HP:0004942)3.92084153
3Premature rupture of membranes (HP:0001788)3.77509280
4Protrusio acetabuli (HP:0003179)3.73059677
5Hematochezia (HP:0002573)3.54889319
6Subacute progressive viral hepatitis (HP:0006572)3.47780963
7Polycythemia (HP:0001901)3.44402987
8Vascular tortuosity (HP:0004948)3.14692285
9Myocardial infarction (HP:0001658)3.13869505
10Arterial tortuosity (HP:0005116)3.13498873
11Aortic dissection (HP:0002647)3.13420690
12Shallow orbits (HP:0000586)3.12034331
13Atrophic scars (HP:0001075)2.97819227
14Hypoplasia of the iris (HP:0007676)2.93951705
15Broad metatarsal (HP:0001783)2.78766262
16Cardiovascular calcification (HP:0011915)2.72260601
17Enlarged penis (HP:0000040)2.67770309
18Asymmetric septal hypertrophy (HP:0001670)2.61055356
19Onycholysis (HP:0001806)2.60058684
20Mutism (HP:0002300)2.57729726
21Short 4th metacarpal (HP:0010044)2.57157499
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57157499
23Aneurysm (HP:0002617)2.54600258
24Spinal rigidity (HP:0003306)2.48144400
25Blue sclerae (HP:0000592)2.47755879
26Abnormality of glycolipid metabolism (HP:0010969)2.46561275
27Abnormality of liposaccharide metabolism (HP:0010968)2.46561275
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.46561275
29Stenosis of the external auditory canal (HP:0000402)2.45027628
30* Esophageal varix (HP:0002040)2.42992986
31Dilatation of the ascending aorta (HP:0005111)2.41368487
32Milia (HP:0001056)2.41349175
33Aplasia cutis congenita (HP:0001057)2.39298364
34Type 1 muscle fiber predominance (HP:0003803)2.37798236
35Overgrowth (HP:0001548)2.37304919
36Congenital, generalized hypertrichosis (HP:0004540)2.36991806
37Facial diplegia (HP:0001349)2.36155628
38Lymphangioma (HP:0100764)2.27932286
39Abnormality of the right ventricle (HP:0001707)2.25273593
40Short hallux (HP:0010109)2.22793596
41Mitral valve prolapse (HP:0001634)2.22690093
42Natal tooth (HP:0000695)2.21348601
43Vascular calcification (HP:0004934)2.19545096
44Scapular winging (HP:0003691)2.17034368
45Follicular hyperkeratosis (HP:0007502)2.16293736
46Capillary hemangiomas (HP:0005306)2.13733043
47Aplasia involving bones of the upper limbs (HP:0009823)2.13284608
48Aplasia of the phalanges of the hand (HP:0009802)2.13284608
49Aplasia involving bones of the extremities (HP:0009825)2.13284608
50* Adactyly (HP:0009776)2.11747828
51Hypophosphatemic rickets (HP:0004912)2.09402658
52Increased connective tissue (HP:0009025)2.08654582
53Plantar hyperkeratosis (HP:0007556)2.07421402
54Blue irides (HP:0000635)2.05904906
55Metaphyseal dysplasia (HP:0100255)2.04943551
56Hypopigmentation of the fundus (HP:0007894)2.04924284
57Popliteal pterygium (HP:0009756)2.04013866
58Aplasia/Hypoplasia of the hallux (HP:0008362)2.02366095
59Increased density of long bones (HP:0006392)2.01800334
60Conjunctival telangiectasia (HP:0000524)2.01460109
61Asymmetry of the thorax (HP:0001555)2.01402909
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00855738
63Fragile nails (HP:0001808)2.00345691
64Absent frontal sinuses (HP:0002688)1.99844056
65Right ventricular cardiomyopathy (HP:0011663)1.98369599
66Venous abnormality (HP:0002624)1.97103493
67Vertebral compression fractures (HP:0002953)1.96391629
68Abnormality of the acetabulum (HP:0003170)1.96125005
69Abnormality of the calf musculature (HP:0001430)1.94119048
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94112672
71Venous insufficiency (HP:0005293)1.92332285
72Advanced eruption of teeth (HP:0006288)1.91413838
73Tetraparesis (HP:0002273)1.90752845
74Bronchomalacia (HP:0002780)1.90670821
75Knee flexion contracture (HP:0006380)1.90337335
76Increased variability in muscle fiber diameter (HP:0003557)1.88541081
77Visceral angiomatosis (HP:0100761)1.88451662
78Bladder neoplasm (HP:0009725)1.87810428
79Bladder carcinoma (HP:0002862)1.87810428
80Transitional cell carcinoma of the bladder (HP:0006740)1.87738008
81Nemaline bodies (HP:0003798)1.87524720
82Hyporeflexia of lower limbs (HP:0002600)1.87475562
83Abnormality of Sharpey fibers (HP:0100685)1.86681164
84Thick nail (HP:0001805)1.85810916
85Wormian bones (HP:0002645)1.84070569
86Single umbilical artery (HP:0001195)1.83211032
87Abnormality of the fetal cardiovascular system (HP:0010948)1.83211032
88Abnormal umbilical cord blood vessels (HP:0011403)1.83211032
89Reduced subcutaneous adipose tissue (HP:0003758)1.83079603
90Camptodactyly of toe (HP:0001836)1.82840770
91Spontaneous hematomas (HP:0007420)1.82453439
92Hemiplegia (HP:0002301)1.82241790
93Abnormality of skeletal muscle fiber size (HP:0012084)1.81964944
94Elbow flexion contracture (HP:0002987)1.81728812
95Wrist flexion contracture (HP:0001239)1.81615482
96Hemangiomatosis (HP:0007461)1.80713833
97Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80447320
98Leiomyosarcoma (HP:0100243)1.80247945
99Uterine leiomyosarcoma (HP:0002891)1.80247945
100Abnormality of the nasal septum (HP:0000419)1.80091242
101Ovoid vertebral bodies (HP:0003300)1.79501254
102Buphthalmos (HP:0000557)1.79383747
103Micronodular cirrhosis (HP:0001413)1.76709764
104Ankyloglossia (HP:0010296)1.76147449
105Abnormality of the 4th metacarpal (HP:0010012)1.76015236
106Cervical subluxation (HP:0003308)1.75945665
107Lipoatrophy (HP:0100578)1.75583788
108Distal lower limb muscle weakness (HP:0009053)1.75344939
109Bladder diverticulum (HP:0000015)1.75033670
110Atrioventricular block (HP:0001678)1.74944295
111Nuclear cataract (HP:0100018)1.74092538
112Spinal cord lesions (HP:0100561)1.73965919
113Syringomyelia (HP:0003396)1.73965919
114Delayed closure of the anterior fontanelle (HP:0001476)1.73413480
115Dysostosis multiplex (HP:0000943)1.72901861
116Hypoalphalipoproteinemia (HP:0003233)1.72723484
117Sudden death (HP:0001699)1.72678715
118Genu recurvatum (HP:0002816)1.72446805
119Mucopolysacchariduria (HP:0008155)1.72311535
120Urinary glycosaminoglycan excretion (HP:0003541)1.72311535
121Pulmonic stenosis (HP:0001642)1.71900484
122Hydroureter (HP:0000072)1.71288366
123Rectal prolapse (HP:0002035)1.71279849
124Ankle contracture (HP:0006466)1.71133966
125Striae distensae (HP:0001065)1.70965940
126Metaphyseal irregularity (HP:0003025)1.70955791
127Aortic valve stenosis (HP:0001650)1.70609216
128Alopecia of scalp (HP:0002293)1.70221884
129Spondylolisthesis (HP:0003302)1.70127979
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.69461903
131Femoral bowing (HP:0002980)1.69423319
132Abnormality of polysaccharide metabolism (HP:0011012)1.69298050
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69298050
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69298050
135Cerebral hemorrhage (HP:0001342)1.68858562
136Muscle fiber splitting (HP:0003555)1.68353729
137Joint stiffness (HP:0001387)1.68285030
138Abnormality of proline metabolism (HP:0010907)1.68237477
139Hydroxyprolinuria (HP:0003080)1.68237477
140Short middle phalanx of the 5th finger (HP:0004220)1.67537473
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67280425
142Confusion (HP:0001289)1.66583247
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.66205462
144Osteolytic defects of the hand bones (HP:0009699)1.66205462
145Fragile skin (HP:0001030)1.65803856
146Acanthosis nigricans (HP:0000956)1.65272655
147Focal segmental glomerulosclerosis (HP:0000097)1.64987564
148Difficulty running (HP:0009046)1.64959934
149Bicuspid aortic valve (HP:0001647)1.64037668
150Abnormality of the peritoneum (HP:0002585)1.63516608
151* Portal hypertension (HP:0001409)1.62931816
152* Skull defect (HP:0001362)1.60989230
153Hyperextensible skin (HP:0000974)1.60398500
154Broad ribs (HP:0000885)1.59560501
155Limited hip movement (HP:0008800)1.59039678
156Hypoplastic ischia (HP:0003175)1.57130565
157Nonimmune hydrops fetalis (HP:0001790)1.56710069
158Soft skin (HP:0000977)1.56084909
159Aplasia/Hypoplasia of the macula (HP:0008059)1.56027430
160* Absent toe (HP:0010760)1.55095571
161Narrow palate (HP:0000189)1.54680011
162Growth hormone excess (HP:0000845)1.54573372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.40558288
2KDR6.27793607
3TGFBR22.96589771
4ACVR1B2.77150560
5ERBB42.73543811
6MST1R2.63804790
7MYLK2.62625551
8LATS12.53633597
9TRIB32.35256769
10INSRR2.28763964
11RIPK12.18844536
12EIF2AK32.16088334
13FLT32.01226245
14PTK2B2.00384595
15DMPK1.96884124
16NUAK11.93685851
17PDK21.76819592
18MST41.70352082
19PDGFRA1.67779183
20BRSK21.67675059
21IRAK31.67591367
22FER1.67234012
23EPHB21.64823132
24BMX1.60343324
25TTN1.57033117
26MARK31.55568316
27FGFR21.50497073
28TGFBR11.48487470
29DDR21.46002730
30MELK1.40262975
31LRRK21.38020846
32MET1.35496528
33MOS1.33485553
34GRK71.33200600
35PRKG21.33137690
36PTK61.27445694
37MAP3K141.25760422
38TSSK61.24916246
39PTK21.20890366
40PBK1.20641736
41CAMK1D1.20158180
42FGFR31.18724534
43BMPR1B1.15992370
44AKT31.15220135
45STK101.14966785
46TRIM281.14399307
47CAMK1G1.11451598
48MKNK21.10435865
49PKN21.07722893
50MAPK120.99526945
51CDK60.97492341
52PAK40.96645581
53FRK0.96598162
54EPHA40.95265887
55NTRK10.94665278
56ITK0.91897952
57FGFR10.90052519
58STK30.89336412
59PRKD30.88715262
60IGF1R0.82919399
61MUSK0.82728042
62PIK3CG0.82683820
63TAF10.81369281
64MAPK70.80331061
65NLK0.80217394
66STK38L0.79668660
67PDGFRB0.77020392
68PRKAA20.77016217
69LATS20.75457142
70PRKD10.74582236
71INSR0.74442871
72OBSCN0.73269586
73PRKCH0.73102786
74NEK20.72574476
75MAP3K120.69693556
76ADRBK10.68872678
77NEK90.67270743
78SIK10.66426837
79MAP3K60.64658907
80PAK20.63196498
81SGK30.62070112
82BRD40.61430830
83TBK10.61169786
84EGFR0.60973554
85PAK30.59660853
86CDK120.58950130
87CDC42BPA0.58477372
88MTOR0.57730109
89RET0.57590652
90NEK10.57263246
91LMTK20.57007415
92ZAK0.56473136
93ABL20.55261731
94SGK20.52683162
95PIK3CA0.52326428
96SRC0.51492792
97FGFR40.51195431
98SCYL20.51058042
99PDPK10.50910000
100MAP2K10.50635137
101GSK3A0.49929416
102GRK10.49258199
103EIF2AK20.49196421
104MAP3K20.49059141
105JAK10.48653610
106TAOK10.47898189
107CLK10.47315096
108CAMKK10.46032659
109STK390.45752876
110PRKCE0.45467027
111ROCK20.45344986
112JAK30.45282925
113PLK30.45058843
114MAP3K30.44940935
115ALK0.44063453
116MAPKAPK30.43644306
117ROCK10.43452191
118ABL10.43379978
119MKNK10.42053676
120ERN10.41000868
121EPHA30.40591087
122EPHB10.39419156
123NTRK20.39127234
124EPHA20.38918847
125AKT20.38381221
126STK240.37226484
127PIM20.36706340
128TYRO30.36538706
129TNIK0.36382969
130MAP3K70.35737198
131PLK20.35166032
132ARAF0.35158148
133MAP2K20.34949000
134CSNK1G10.34810629
135ZAP700.34284313
136CHUK0.34106009
137SIK30.33517794
138TRPM70.33221040
139FES0.33206544
140TEC0.32962293
141PRKD20.31205792
142CSK0.30914976
143KSR20.30693626
144MAPK150.28799845
145PRKCQ0.28288490
146MARK20.27369985
147RPS6KA40.27124265
148ERBB30.26913781
149MAP3K10.25375191
150MAP2K30.25146663

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.88775547
2Nitrogen metabolism_Homo sapiens_hsa009102.65121573
3ECM-receptor interaction_Homo sapiens_hsa045122.29171334
4Focal adhesion_Homo sapiens_hsa045102.14579029
5Lysosome_Homo sapiens_hsa041421.81536735
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73355913
7Dorso-ventral axis formation_Homo sapiens_hsa043201.70186205
8Rap1 signaling pathway_Homo sapiens_hsa040151.68115038
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67619807
10Proteoglycans in cancer_Homo sapiens_hsa052051.67065496
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64045646
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61980247
13Dilated cardiomyopathy_Homo sapiens_hsa054141.59430793
14Rheumatoid arthritis_Homo sapiens_hsa053231.59410750
15Small cell lung cancer_Homo sapiens_hsa052221.56575410
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.52325638
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47233799
18Renal cell carcinoma_Homo sapiens_hsa052111.40043589
19TGF-beta signaling pathway_Homo sapiens_hsa043501.39478766
20p53 signaling pathway_Homo sapiens_hsa041151.39276796
21HIF-1 signaling pathway_Homo sapiens_hsa040661.38979092
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38205528
23Melanogenesis_Homo sapiens_hsa049161.34042391
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25651125
25Hippo signaling pathway_Homo sapiens_hsa043901.22363634
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21794631
27Amoebiasis_Homo sapiens_hsa051461.21153501
28VEGF signaling pathway_Homo sapiens_hsa043701.18383724
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15895398
30Sulfur metabolism_Homo sapiens_hsa009201.15624867
31PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14608826
32Platelet activation_Homo sapiens_hsa046111.13534959
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12918879
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12402956
35Tight junction_Homo sapiens_hsa045301.12314893
36Axon guidance_Homo sapiens_hsa043601.12271014
37Glioma_Homo sapiens_hsa052141.11868546
38MicroRNAs in cancer_Homo sapiens_hsa052061.11486136
39Ovarian steroidogenesis_Homo sapiens_hsa049131.11202022
40Other glycan degradation_Homo sapiens_hsa005111.10810488
41Pertussis_Homo sapiens_hsa051331.09958562
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08432532
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08344422
44Ras signaling pathway_Homo sapiens_hsa040141.08135922
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08128422
46Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06735700
47Vitamin digestion and absorption_Homo sapiens_hsa049771.06473391
48Estrogen signaling pathway_Homo sapiens_hsa049151.06046686
49Legionellosis_Homo sapiens_hsa051341.04901875
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04753159
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.02884345
52Prostate cancer_Homo sapiens_hsa052151.02353073
53Melanoma_Homo sapiens_hsa052181.00483828
54Pathways in cancer_Homo sapiens_hsa052000.99856267
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99671992
56Sphingolipid metabolism_Homo sapiens_hsa006000.99102458
57Complement and coagulation cascades_Homo sapiens_hsa046100.98890000
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98761963
59Selenocompound metabolism_Homo sapiens_hsa004500.96030862
60Chronic myeloid leukemia_Homo sapiens_hsa052200.95927218
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.94103070
62Gastric acid secretion_Homo sapiens_hsa049710.94081672
63Protein digestion and absorption_Homo sapiens_hsa049740.94011461
64Toxoplasmosis_Homo sapiens_hsa051450.93642827
65Bile secretion_Homo sapiens_hsa049760.93251434
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92156988
67Gap junction_Homo sapiens_hsa045400.92136157
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.92085896
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90039782
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88912547
71African trypanosomiasis_Homo sapiens_hsa051430.88591039
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87550171
73cAMP signaling pathway_Homo sapiens_hsa040240.85836588
74Endocytosis_Homo sapiens_hsa041440.85774991
75Salivary secretion_Homo sapiens_hsa049700.84502422
76Pancreatic cancer_Homo sapiens_hsa052120.83153006
77Viral myocarditis_Homo sapiens_hsa054160.81944331
78GnRH signaling pathway_Homo sapiens_hsa049120.81812969
79Oxytocin signaling pathway_Homo sapiens_hsa049210.81497900
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80628658
81Long-term depression_Homo sapiens_hsa047300.80594744
82Renin secretion_Homo sapiens_hsa049240.79816147
83Basal cell carcinoma_Homo sapiens_hsa052170.79301285
84Choline metabolism in cancer_Homo sapiens_hsa052310.78504293
85FoxO signaling pathway_Homo sapiens_hsa040680.77425787
86Circadian rhythm_Homo sapiens_hsa047100.77262147
87Insulin resistance_Homo sapiens_hsa049310.76667128
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76525660
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76155302
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75981276
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.75290062
92Osteoclast differentiation_Homo sapiens_hsa043800.74827871
93Colorectal cancer_Homo sapiens_hsa052100.74320202
94Long-term potentiation_Homo sapiens_hsa047200.72682933
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.72630664
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.72548741
97Notch signaling pathway_Homo sapiens_hsa043300.72449746
98TNF signaling pathway_Homo sapiens_hsa046680.71530010
99Mineral absorption_Homo sapiens_hsa049780.71527107
100MAPK signaling pathway_Homo sapiens_hsa040100.69631923
101Wnt signaling pathway_Homo sapiens_hsa043100.69273476
102Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67686448
103Bladder cancer_Homo sapiens_hsa052190.66676966
104mTOR signaling pathway_Homo sapiens_hsa041500.66071257
105Endometrial cancer_Homo sapiens_hsa052130.65670271
106Thyroid cancer_Homo sapiens_hsa052160.64492434
107Insulin secretion_Homo sapiens_hsa049110.64377775
108Cholinergic synapse_Homo sapiens_hsa047250.63121548
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63029430
110Circadian entrainment_Homo sapiens_hsa047130.62768780
111Measles_Homo sapiens_hsa051620.62714571
112Phagosome_Homo sapiens_hsa041450.62389153
113Shigellosis_Homo sapiens_hsa051310.62123862
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.61991747
115Malaria_Homo sapiens_hsa051440.61702576
116Arginine biosynthesis_Homo sapiens_hsa002200.60149390
117Thyroid hormone synthesis_Homo sapiens_hsa049180.59308720
118Pancreatic secretion_Homo sapiens_hsa049720.58968002
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58403399
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57997669
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56630818
122Salmonella infection_Homo sapiens_hsa051320.56496100
123HTLV-I infection_Homo sapiens_hsa051660.56397467
124Glutamatergic synapse_Homo sapiens_hsa047240.55904906
125Hematopoietic cell lineage_Homo sapiens_hsa046400.55405632
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.54708668
127Hepatitis C_Homo sapiens_hsa051600.53393220
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51343060
129Basal transcription factors_Homo sapiens_hsa030220.50881594
130Influenza A_Homo sapiens_hsa051640.49781513
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47644099
132Renin-angiotensin system_Homo sapiens_hsa046140.46600719
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44266865
134Apoptosis_Homo sapiens_hsa042100.43512731
135Tuberculosis_Homo sapiens_hsa051520.41722044
136Hepatitis B_Homo sapiens_hsa051610.40075455
137Leishmaniasis_Homo sapiens_hsa051400.39923755
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38514477

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