EOMES

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.76727797
2daunorubicin metabolic process (GO:0044597)6.19930325
3polyketide metabolic process (GO:0030638)6.19930325
4doxorubicin metabolic process (GO:0044598)6.19930325
5cell migration involved in gastrulation (GO:0042074)6.09001043
6somite rostral/caudal axis specification (GO:0032525)5.63098294
7protein localization to kinetochore (GO:0034501)5.61705372
8positive regulation of gastrulation (GO:2000543)5.56897158
9regulation of telomere maintenance via telomerase (GO:0032210)5.22178312
10primitive streak formation (GO:0090009)5.17481326
11DNA deamination (GO:0045006)5.12995522
12* endoderm formation (GO:0001706)5.12789938
13pre-miRNA processing (GO:0031054)5.06174113
14negative regulation of axon extension involved in axon guidance (GO:0048843)4.96080779
15regulation of nuclear cell cycle DNA replication (GO:0033262)4.75952117
16histone H4-K12 acetylation (GO:0043983)4.74915171
17cerebellar Purkinje cell differentiation (GO:0021702)4.73425595
18pyrimidine nucleobase catabolic process (GO:0006208)4.71593742
19negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.66161198
20regulation of posttranscriptional gene silencing (GO:0060147)4.63982650
21regulation of gene silencing by miRNA (GO:0060964)4.63982650
22regulation of gene silencing by RNA (GO:0060966)4.63982650
23signal transduction involved in regulation of gene expression (GO:0023019)4.58395912
24forebrain neuron differentiation (GO:0021879)4.56903724
25head development (GO:0060322)4.55429051
26regulation of mammary gland epithelial cell proliferation (GO:0033599)4.54889798
27* olfactory bulb development (GO:0021772)4.54809922
28maintenance of protein location in nucleus (GO:0051457)4.51313748
29histone H4-K5 acetylation (GO:0043981)4.49918747
30histone H4-K8 acetylation (GO:0043982)4.49918747
31heterochromatin organization (GO:0070828)4.46634447
32mitotic sister chromatid segregation (GO:0000070)4.46530186
33negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.46241454
34regulation of collateral sprouting (GO:0048670)4.45835135
35negative regulation of transcription regulatory region DNA binding (GO:2000678)4.43701781
36nuclear pore complex assembly (GO:0051292)4.40289398
37negative regulation of telomerase activity (GO:0051974)4.39677296
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.37802609
39negative regulation of epidermis development (GO:0045683)4.28601272
40negative regulation of axon guidance (GO:1902668)4.26997291
41protein localization to chromosome, centromeric region (GO:0071459)4.23284343
42uterus development (GO:0060065)4.21698018
43nuclear pore organization (GO:0006999)4.21067872
44DNA replication-dependent nucleosome organization (GO:0034723)4.16735785
45DNA replication-dependent nucleosome assembly (GO:0006335)4.16735785
46rRNA transcription (GO:0009303)4.16398590
47ganglion development (GO:0061548)4.15214976
48cell proliferation in forebrain (GO:0021846)4.13983253
49negative regulation of activin receptor signaling pathway (GO:0032926)4.13722888
50regulation of response to osmotic stress (GO:0047484)4.11699427
51DNA unwinding involved in DNA replication (GO:0006268)4.10792046
52sequestering of extracellular ligand from receptor (GO:0035581)4.10685585
53phospholipid scrambling (GO:0017121)4.09488014
54spinal cord association neuron differentiation (GO:0021527)4.03051017
55protein neddylation (GO:0045116)4.01025349
56chaperone-mediated protein transport (GO:0072321)3.99924514
57regulation of MHC class I biosynthetic process (GO:0045343)3.99049757
58negative regulation of cell cycle G2/M phase transition (GO:1902750)3.98173657
59notochord development (GO:0030903)3.87753901
60DNA replication checkpoint (GO:0000076)3.86284957
61sister chromatid segregation (GO:0000819)3.84964398
62cell fate commitment involved in formation of primary germ layer (GO:0060795)3.83963833
63aminoglycoside antibiotic metabolic process (GO:0030647)3.80604567
64activated T cell proliferation (GO:0050798)3.80587097
65dendritic spine morphogenesis (GO:0060997)3.77452492
66rRNA modification (GO:0000154)3.74720909
67chromatin assembly (GO:0031497)3.73650954
68formation of translation preinitiation complex (GO:0001731)3.73264709
69cytidine metabolic process (GO:0046087)3.71054391
70cytidine catabolic process (GO:0006216)3.71054391
71cytidine deamination (GO:0009972)3.71054391
72rRNA methylation (GO:0031167)3.70338019
73regulation of mesoderm development (GO:2000380)3.69630138
74regulation of translation in response to stress (GO:0043555)3.66050027
75ribosome biogenesis (GO:0042254)3.59968115
76anterior/posterior axis specification, embryo (GO:0008595)3.56131168
77histone H4-K16 acetylation (GO:0043984)3.49960762
78negative regulation of telomere maintenance (GO:0032205)3.49571245
79pyrimidine ribonucleoside catabolic process (GO:0046133)3.48612806
80positive regulation of DNA-dependent DNA replication (GO:2000105)3.48138863
81DNA duplex unwinding (GO:0032508)3.46688426
82protein polyglutamylation (GO:0018095)3.45874809
83anterior/posterior axis specification (GO:0009948)3.44040863
84nucleobase catabolic process (GO:0046113)3.43435358
85muscle organ morphogenesis (GO:0048644)3.43079697
86negative regulation of epidermal cell differentiation (GO:0045605)3.42658341
87DNA geometric change (GO:0032392)3.42151387
88* interferon-gamma production (GO:0032609)3.40680401
89neurofilament cytoskeleton organization (GO:0060052)3.38609513
90cerebral cortex radially oriented cell migration (GO:0021799)3.37560528
91regulation of development, heterochronic (GO:0040034)3.36539008
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35955471
93regulation of timing of cell differentiation (GO:0048505)3.34704443
94urogenital system development (GO:0001655)3.34630399
95RNA stabilization (GO:0043489)3.32212717
96mRNA stabilization (GO:0048255)3.32212717
97transmission of nerve impulse (GO:0019226)3.30930665
98regulation of hippo signaling (GO:0035330)3.29354809
99neuron recognition (GO:0008038)3.26769287
100neural tube formation (GO:0001841)3.25475770
101pore complex assembly (GO:0046931)3.24680289
102establishment of mitochondrion localization (GO:0051654)3.21036959
103regulation of axon extension involved in axon guidance (GO:0048841)3.20456818
104mitotic chromosome condensation (GO:0007076)3.20268863
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.19211855
106substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.17774207
107substrate-independent telencephalic tangential migration (GO:0021826)3.17774207
108regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.17674146
109intraciliary transport (GO:0042073)3.16858064
110lung morphogenesis (GO:0060425)3.14247770
111gastrulation (GO:0007369)3.13950223
112regulation of activin receptor signaling pathway (GO:0032925)3.13033455
113synaptic transmission, cholinergic (GO:0007271)3.12813015
114epithelial cilium movement (GO:0003351)3.12710089
115pseudouridine synthesis (GO:0001522)3.12235508
116N-glycan processing (GO:0006491)3.11847820
117intracellular estrogen receptor signaling pathway (GO:0030520)3.11007133
118intestinal epithelial cell development (GO:0060576)3.11001136
119retinal ganglion cell axon guidance (GO:0031290)3.10444946
120fat-soluble vitamin catabolic process (GO:0042363)3.05428912
121vitamin catabolic process (GO:0009111)3.05428912
122DNA damage response, detection of DNA damage (GO:0042769)3.04000806
123limb bud formation (GO:0060174)3.03892653
124axonal fasciculation (GO:0007413)3.03314470
125regulation of telomere maintenance (GO:0032204)3.02451113
126nodal signaling pathway (GO:0038092)3.02284053
127intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.99716003
128DNA replication initiation (GO:0006270)2.99436094
129regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.99235040
130histone arginine methylation (GO:0034969)2.98867669
131mitochondrion transport along microtubule (GO:0047497)2.98709237
132establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98709237
133ribosomal small subunit biogenesis (GO:0042274)2.98205443
134ribonucleoprotein complex biogenesis (GO:0022613)2.96885555
135regulation of axon guidance (GO:1902667)2.96417380
136embryonic axis specification (GO:0000578)2.95785792
137negative regulation of cell fate commitment (GO:0010454)2.95484428
138mitotic nuclear envelope disassembly (GO:0007077)2.94445498
139establishment or maintenance of monopolar cell polarity (GO:0061339)2.89536091
140establishment of monopolar cell polarity (GO:0061162)2.89536091
141spinal cord development (GO:0021510)2.89374627
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.89280551
143cell migration in hindbrain (GO:0021535)2.88325277
144peptidyl-arginine omega-N-methylation (GO:0035247)2.87459322
145negative regulation of axon extension (GO:0030517)2.87379427
146neuronal ion channel clustering (GO:0045161)2.86634807
147cellular response to BMP stimulus (GO:0071773)2.86528225
148response to BMP (GO:0071772)2.86528225
149presynaptic membrane organization (GO:0097090)2.85647493
150regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.85524904
151somite development (GO:0061053)2.84928428
152SMAD protein signal transduction (GO:0060395)2.82840923
153* trophectodermal cell differentiation (GO:0001829)2.81788278
154paraxial mesoderm development (GO:0048339)2.81219263
155regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80230730
156negative regulation of gene silencing (GO:0060969)2.79148762
157neuron projection extension involved in neuron projection guidance (GO:1902284)2.78976295
158axon extension involved in axon guidance (GO:0048846)2.78976295
159interferon-gamma secretion (GO:0072643)2.78908457
160branching involved in mammary gland duct morphogenesis (GO:0060444)2.78620415
161telencephalon development (GO:0021537)2.76276841
162regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76091410
163dorsal/ventral pattern formation (GO:0009953)2.75082045
164protein localization to synapse (GO:0035418)2.74466853
165regulation of gene silencing (GO:0060968)2.74240279
166regulation of telomerase activity (GO:0051972)2.74203318
167negative regulation of histone methylation (GO:0031061)2.74090710
168ncRNA catabolic process (GO:0034661)2.72690055
169cilium movement (GO:0003341)2.72521814
170postsynaptic membrane organization (GO:0001941)2.72363654
171DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.72025127
172membrane disassembly (GO:0030397)2.71149110
173nuclear envelope disassembly (GO:0051081)2.71149110
174axon extension (GO:0048675)2.70604394
175negative regulation of macroautophagy (GO:0016242)2.69484082
176regulation of cilium movement (GO:0003352)2.69111072
177central nervous system projection neuron axonogenesis (GO:0021952)2.69039616
178motor neuron axon guidance (GO:0008045)2.68474057
179presynaptic membrane assembly (GO:0097105)2.68171385
180negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66225390
181negative regulation of translation, ncRNA-mediated (GO:0040033)2.66225390
182regulation of translation, ncRNA-mediated (GO:0045974)2.66225390
183folic acid-containing compound biosynthetic process (GO:0009396)2.65995875
184female gonad development (GO:0008585)2.65471853
185retinoic acid receptor signaling pathway (GO:0048384)2.65235580
186negative regulation of axonogenesis (GO:0050771)2.62765001
187lateral ventricle development (GO:0021670)2.61294304
188DNA conformation change (GO:0071103)2.61048878
189positive regulation of cell size (GO:0045793)2.59775038
190spindle assembly (GO:0051225)2.58605573
191transcription from mitochondrial promoter (GO:0006390)2.57146119
192secondary heart field specification (GO:0003139)2.55394487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32760112
2EZH2_22144423_ChIP-Seq_EOC_Human5.43597765
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.99358656
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.99358656
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.99358656
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.31015915
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.89155159
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.41477456
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.15125457
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10453889
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.01056640
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98890049
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.98308355
14* TP63_19390658_ChIP-ChIP_HaCaT_Human2.84452445
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.61930627
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.60116379
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.59681743
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.57764432
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55096906
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.49158701
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37198899
22* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.31906048
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29043192
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.28883645
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.25099687
26* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.17139184
27MYC_22102868_ChIP-Seq_BL_Human2.15489857
28* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14401489
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.13233972
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13089315
31REST_21632747_ChIP-Seq_MESCs_Mouse2.05885167
32* RNF2_27304074_Chip-Seq_NSC_Mouse1.94529763
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93209810
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92476203
35* SMAD3_21741376_ChIP-Seq_HESCs_Human1.91462453
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.90232863
37* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.89805883
38* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89444669
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88948542
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.84768538
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84540174
42* RNF2_27304074_Chip-Seq_ESCs_Mouse1.83788181
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.83089057
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.82582973
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80780318
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.79621393
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79374910
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79374910
49IGF1R_20145208_ChIP-Seq_DFB_Human1.78548535
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77940532
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77813667
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73615944
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.71602395
54* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71427527
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.70160698
56VDR_22108803_ChIP-Seq_LS180_Human1.69756111
57ZNF274_21170338_ChIP-Seq_K562_Hela1.69646068
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68179183
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68069029
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.67526997
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66499017
62* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65094383
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.64271598
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61343849
65* SMAD4_21741376_ChIP-Seq_HESCs_Human1.60874966
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60186654
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59643634
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57652083
69TAF15_26573619_Chip-Seq_HEK293_Human1.56356623
70* EED_16625203_ChIP-ChIP_MESCs_Mouse1.55095186
71XRN2_22483619_ChIP-Seq_HELA_Human1.53620904
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53509413
73* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51769412
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.51244393
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.49823453
76P300_19829295_ChIP-Seq_ESCs_Human1.48972229
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48226015
78* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47710051
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47442698
80EWS_26573619_Chip-Seq_HEK293_Human1.47241135
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47032620
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46613040
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45013677
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44283957
85* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42900209
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42382207
87* RING1B_27294783_Chip-Seq_ESCs_Mouse1.42233159
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.42127492
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41222571
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.38103649
91* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37940339
92* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37940339
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37577577
94* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.37056476
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.36993370
96* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36664696
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.36266248
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35825682
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35464670
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.35286373
101* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34464384
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33426709
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.33209980
104* SMAD4_21741376_ChIP-Seq_EPCs_Human1.32985693
105ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32379783
106* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32351977
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.32345351
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31087855
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29512966
110IRF1_19129219_ChIP-ChIP_H3396_Human1.29286361
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28966457
112* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27643736
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27449527
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.27435448
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.26659479
116CIITA_25753668_ChIP-Seq_RAJI_Human1.26431010
117* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.26193613
118NANOG_21062744_ChIP-ChIP_HESCs_Human1.25529519
119NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23284679
120* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21725952
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21264491
122FOXP3_21729870_ChIP-Seq_TREG_Human1.19734689
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19509772
124* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19145973
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18682189
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17651028
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.16598633
128* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15416919
129JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15231990
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15017898
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15009309
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13368786
133TTF2_22483619_ChIP-Seq_HELA_Human1.13239618
134PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12630462
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12559533
136* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12427916
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12190097
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12121137
139EOMES_21245162_ChIP-Seq_HESCs_Human1.12047187
140E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11884040
141KDM5A_27292631_Chip-Seq_BREAST_Human1.11016849
142* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10750529
143* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09526674
144KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09404449
145* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09213731
146RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09199123
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09129978
148CBP_20019798_ChIP-Seq_JUKART_Human1.09129978
149* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07145281
150AR_21909140_ChIP-Seq_LNCAP_Human1.05698004
151FUS_26573619_Chip-Seq_HEK293_Human1.05323485
152* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04893734
153TCF7_22412390_ChIP-Seq_EML_Mouse1.04379787
154* PRDM14_20953172_ChIP-Seq_ESCs_Human1.02624284
155GABP_17652178_ChIP-ChIP_JURKAT_Human1.02101203
156VDR_23849224_ChIP-Seq_CD4+_Human1.01353146
157TP53_22573176_ChIP-Seq_HFKS_Human1.01227149
158* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00927995
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00854124
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00091163
161ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99897855
162HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99527570
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99253941
164KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99238553
165E2F1_21310950_ChIP-Seq_MCF-7_Human0.99236921
166CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99191550
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98765926
168CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98125213
169* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97631138
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97288967
171NCOR1_26117541_ChIP-Seq_K562_Human0.96513376
172SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95911036
173GABP_19822575_ChIP-Seq_HepG2_Human0.95383764
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.94940817
175NANOG_20526341_ChIP-Seq_ESCs_Human0.94718884
176E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94182566
177GBX2_23144817_ChIP-Seq_PC3_Human0.93931804
178HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93736260
179* NANOG_16518401_ChIP-PET_MESCs_Mouse0.92471416
180RUNX2_22187159_ChIP-Seq_PCA_Human0.91707665
181KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91477313
182AR_25329375_ChIP-Seq_VCAP_Human0.91429068
183TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91230809
184BCAT_22108803_ChIP-Seq_LS180_Human0.90912768
185* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90826940
186ELK3_25401928_ChIP-Seq_HUVEC_Human0.90746569
187THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90229000
188EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87546684
189ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83680250
190YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83029112
191TP53_22127205_ChIP-Seq_IMR90_Human0.82915709
192E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82138122
193NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81212901

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting4.26694989
2MP0006292_abnormal_olfactory_placode4.20774418
3MP0002254_reproductive_system_inflammat3.47961585
4* MP0004957_abnormal_blastocyst_morpholog3.40006656
5* MP0003890_abnormal_embryonic-extraembry3.32916003
6MP0005394_taste/olfaction_phenotype3.14795761
7MP0005499_abnormal_olfactory_system3.14795761
8MP0008057_abnormal_DNA_replication3.07380327
9MP0003880_abnormal_central_pattern3.06562703
10MP0002653_abnormal_ependyma_morphology2.72121672
11MP0004264_abnormal_extraembryonic_tissu2.67389232
12MP0002163_abnormal_gland_morphology2.65601751
13MP0006276_abnormal_autonomic_nervous2.64795029
14MP0010352_gastrointestinal_tract_polyps2.56811773
15* MP0000778_abnormal_nervous_system2.44129750
16MP0003011_delayed_dark_adaptation2.42331862
17MP0003077_abnormal_cell_cycle2.38390798
18MP0003111_abnormal_nucleus_morphology2.35411545
19MP0002638_abnormal_pupillary_reflex2.34469336
20MP0003693_abnormal_embryo_hatching2.30418680
21* MP0005380_embryogenesis_phenotype2.27595869
22* MP0001672_abnormal_embryogenesis/_devel2.27595869
23MP0010030_abnormal_orbit_morphology2.26080562
24MP0002088_abnormal_embryonic_growth/wei2.10433595
25MP0003984_embryonic_growth_retardation2.09392575
26MP0003123_paternal_imprinting2.08288345
27MP0003119_abnormal_digestive_system2.04358504
28MP0000678_abnormal_parathyroid_gland2.00741478
29MP0005075_abnormal_melanosome_morpholog1.98192016
30MP0001485_abnormal_pinna_reflex1.95762680
31MP0003121_genomic_imprinting1.95128557
32MP0008932_abnormal_embryonic_tissue1.93929703
33* MP0002084_abnormal_developmental_patter1.87874361
34MP0006082_CNS_inflammation1.87488053
35MP0001293_anophthalmia1.85832952
36MP0000350_abnormal_cell_proliferation1.85168544
37MP0010094_abnormal_chromosome_stability1.80066427
38* MP0002085_abnormal_embryonic_tissue1.78427167
39MP0003705_abnormal_hypodermis_morpholog1.77921018
40MP0008789_abnormal_olfactory_epithelium1.76755457
41MP0004858_abnormal_nervous_system1.75985768
42MP0004133_heterotaxia1.74130251
43* MP0001730_embryonic_growth_arrest1.73896182
44MP0003122_maternal_imprinting1.73503839
45* MP0002086_abnormal_extraembryonic_tissu1.68226596
46MP0003938_abnormal_ear_development1.67412747
47MP0008877_abnormal_DNA_methylation1.64359922
48MP0000428_abnormal_craniofacial_morphol1.63992494
49MP0001697_abnormal_embryo_size1.61170612
50MP0002332_abnormal_exercise_endurance1.60433838
51MP0004742_abnormal_vestibular_system1.57325145
52MP0002184_abnormal_innervation1.54757302
53MP0000049_abnormal_middle_ear1.50925836
54MP0004145_abnormal_muscle_electrophysio1.46401940
55MP0001529_abnormal_vocalization1.45746710
56MP0004197_abnormal_fetal_growth/weight/1.42775365
57MP0000955_abnormal_spinal_cord1.41464476
58MP0002127_abnormal_cardiovascular_syste1.41367637
59MP0004885_abnormal_endolymph1.39973827
60MP0002160_abnormal_reproductive_system1.37457983
61MP0002092_abnormal_eye_morphology1.35703201
62MP0002932_abnormal_joint_morphology1.35620793
63MP0006035_abnormal_mitochondrial_morpho1.35418748
64MP0003567_abnormal_fetal_cardiomyocyte1.35266615
65MP0003937_abnormal_limbs/digits/tail_de1.35163378
66MP0001919_abnormal_reproductive_system1.33456755
67* MP0002752_abnormal_somatic_nervous1.31711877
68MP0000432_abnormal_head_morphology1.31688161
69* MP0002080_prenatal_lethality1.29748479
70MP0001849_ear_inflammation1.29562448
71MP0005423_abnormal_somatic_nervous1.27185874
72MP0005551_abnormal_eye_electrophysiolog1.25273899
73MP0003195_calcinosis1.24961252
74MP0003315_abnormal_perineum_morphology1.24949312
75MP0005389_reproductive_system_phenotype1.24292048
76* MP0002557_abnormal_social/conspecific_i1.24254811
77MP0005257_abnormal_intraocular_pressure1.24153952
78MP0003935_abnormal_craniofacial_develop1.22958992
79MP0001188_hyperpigmentation1.21671140
80MP0003635_abnormal_synaptic_transmissio1.21527029
81MP0002736_abnormal_nociception_after1.21368857
82* MP0002882_abnormal_neuron_morphology1.20804567
83MP0000631_abnormal_neuroendocrine_gland1.20019754
84MP0008995_early_reproductive_senescence1.19822003
85MP0002396_abnormal_hematopoietic_system1.19535662
86MP0002272_abnormal_nervous_system1.16970752
87MP0008007_abnormal_cellular_replicative1.16872308
88MP0002233_abnormal_nose_morphology1.16669700
89MP0000490_abnormal_crypts_of1.13502375
90MP0001440_abnormal_grooming_behavior1.11927177
91MP0002111_abnormal_tail_morphology1.11506863
92MP0000762_abnormal_tongue_morphology1.10454286
93MP0002102_abnormal_ear_morphology1.09819194
94MP0002067_abnormal_sensory_capabilities1.09818891
95MP0000313_abnormal_cell_death1.09779364
96* MP0002152_abnormal_brain_morphology1.08630603
97MP0002277_abnormal_respiratory_mucosa1.08026865
98MP0008058_abnormal_DNA_repair1.07970323
99MP0004142_abnormal_muscle_tone1.07926677
100* MP0005195_abnormal_posterior_eye1.06003438
101MP0008770_decreased_survivor_rate1.05057020
102MP0002114_abnormal_axial_skeleton1.04935294
103MP0000538_abnormal_urinary_bladder1.04790422
104MP0002925_abnormal_cardiovascular_devel1.03619951
105MP0003385_abnormal_body_wall1.03513318
106MP0003755_abnormal_palate_morphology1.02820081
107* MP0006072_abnormal_retinal_apoptosis1.02810433
108* MP0003861_abnormal_nervous_system1.02271773
109* MP0004811_abnormal_neuron_physiology1.01040481
110MP0005248_abnormal_Harderian_gland0.99431350
111MP0000537_abnormal_urethra_morphology0.99415788
112MP0000703_abnormal_thymus_morphology0.99298594
113MP0005386_behavior/neurological_phenoty0.99145804
114MP0004924_abnormal_behavior0.99145804
115MP0004270_analgesia0.98736928
116MP0005379_endocrine/exocrine_gland_phen0.98503403
117* MP0002572_abnormal_emotion/affect_behav0.98113512
118MP0002063_abnormal_learning/memory/cond0.97684702
119MP0003763_abnormal_thymus_physiology0.96483021
120MP0005671_abnormal_response_to0.96343353
121MP0002751_abnormal_autonomic_nervous0.94891653
122MP0001968_abnormal_touch/_nociception0.94851890
123MP0009703_decreased_birth_body0.94503972
124MP0002116_abnormal_craniofacial_bone0.93468185
125MP0002928_abnormal_bile_duct0.93385628
126MP0002734_abnormal_mechanical_nocicepti0.93119678
127MP0002132_abnormal_respiratory_system0.93053600
128MP0003448_altered_tumor_morphology0.92616514
129MP0001286_abnormal_eye_development0.92177228
130MP0000858_altered_metastatic_potential0.91716189
131MP0009379_abnormal_foot_pigmentation0.91032759
132MP0001348_abnormal_lacrimal_gland0.89279354
133MP0002234_abnormal_pharynx_morphology0.89196550
134MP0001984_abnormal_olfaction0.89093603
135MP0005084_abnormal_gallbladder_morpholo0.87431051
136MP0008961_abnormal_basal_metabolism0.86938212
137MP0004381_abnormal_hair_follicle0.84720355
138MP0003137_abnormal_impulse_conducting0.81456402
139MP0008872_abnormal_physiological_respon0.81281714
140MP0000372_irregular_coat_pigmentation0.79820805
141* MP0005253_abnormal_eye_physiology0.79504610
142MP0001970_abnormal_pain_threshold0.79330806
143MP0002722_abnormal_immune_system0.79126200
144MP0000569_abnormal_digit_pigmentation0.78435715
145* MP0002019_abnormal_tumor_incidence0.77864450
146MP0001986_abnormal_taste_sensitivity0.77701283
147MP0001119_abnormal_female_reproductive0.77408519
148MP0002098_abnormal_vibrissa_morphology0.76373763
149MP0009745_abnormal_behavioral_response0.75991357
150MP0002735_abnormal_chemical_nociception0.75771424
151MP0009333_abnormal_splenocyte_physiolog0.74968019
152MP0002210_abnormal_sex_determination0.74873909
153MP0002697_abnormal_eye_size0.73881783
154MP0002081_perinatal_lethality0.73100026
155MP0005076_abnormal_cell_differentiation0.72620140
156MP0002822_catalepsy0.72612172
157MP0004859_abnormal_synaptic_plasticity0.72568092
158MP0009046_muscle_twitch0.72230066
159MP0003936_abnormal_reproductive_system0.72072005
160MP0001963_abnormal_hearing_physiology0.71181861
161MP0002249_abnormal_larynx_morphology0.71144627
162MP0000427_abnormal_hair_cycle0.69717593
163MP0000026_abnormal_inner_ear0.69076809
164MP0001486_abnormal_startle_reflex0.67713381
165* MP0005391_vision/eye_phenotype0.67168407
166MP0005266_abnormal_metabolism0.65743838
167MP0003942_abnormal_urinary_system0.65700197
168MP0000358_abnormal_cell_content/0.63890347
169MP0009053_abnormal_anal_canal0.62814421
170MP0009672_abnormal_birth_weight0.62661042
171MP0000689_abnormal_spleen_morphology0.62167724

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)6.06418372
2Bilateral microphthalmos (HP:0007633)5.35228569
3Rib fusion (HP:0000902)5.10603552
4Congenital malformation of the right heart (HP:0011723)4.66794439
5Double outlet right ventricle (HP:0001719)4.66794439
6Hepatoblastoma (HP:0002884)4.30873226
7Multiple enchondromatosis (HP:0005701)4.13152278
8Ependymoma (HP:0002888)4.10126409
9Hypochromic microcytic anemia (HP:0004840)3.89617864
10Abnormality of the lower motor neuron (HP:0002366)3.63383390
11Rectal fistula (HP:0100590)3.57421316
12Rectovaginal fistula (HP:0000143)3.57421316
13Diastasis recti (HP:0001540)3.44772537
14Intestinal fistula (HP:0100819)3.41230433
15Fused cervical vertebrae (HP:0002949)3.35516998
16Aplasia/hypoplasia of the humerus (HP:0006507)3.34681655
17Partial duplication of thumb phalanx (HP:0009944)3.34286470
18Neoplasm of striated muscle (HP:0009728)3.33718853
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32848060
20Rhabdomyosarcoma (HP:0002859)3.29886160
21Intestinal atresia (HP:0011100)3.29219903
22Agitation (HP:0000713)3.25109320
23Asplenia (HP:0001746)3.20242563
24Oligodactyly (hands) (HP:0001180)3.17927630
25Short humerus (HP:0005792)3.16698370
26Aplasia/Hypoplasia of the spleen (HP:0010451)3.14311437
27Shawl scrotum (HP:0000049)3.02085693
28Abnormal lung lobation (HP:0002101)3.01691084
29Vaginal fistula (HP:0004320)2.96969516
30Partial duplication of the phalanx of hand (HP:0009999)2.96934423
31Preauricular skin tag (HP:0000384)2.96500413
32Chromsome breakage (HP:0040012)2.93566836
33Nephroblastoma (Wilms tumor) (HP:0002667)2.87903527
34Amyotrophic lateral sclerosis (HP:0007354)2.84068075
35Astrocytoma (HP:0009592)2.77324623
36Abnormality of the astrocytes (HP:0100707)2.77324623
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77078474
38Trismus (HP:0000211)2.73772921
39Skin tags (HP:0010609)2.73209472
40Embryonal renal neoplasm (HP:0011794)2.71103645
41Molar tooth sign on MRI (HP:0002419)2.71091422
42Abnormality of midbrain morphology (HP:0002418)2.71091422
43Labial hypoplasia (HP:0000066)2.69554626
44Adrenal hypoplasia (HP:0000835)2.67505815
45Neonatal hypoglycemia (HP:0001998)2.66018673
46Abnormality of the aortic arch (HP:0012303)2.63730868
47Anomalous pulmonary venous return (HP:0010772)2.59192417
48Abnormality of the distal phalanx of the thumb (HP:0009617)2.56084794
49Meckel diverticulum (HP:0002245)2.52953757
50Medulloblastoma (HP:0002885)2.51944745
51Supernumerary spleens (HP:0009799)2.51311757
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.50852715
53Volvulus (HP:0002580)2.50721160
54Pancreatic fibrosis (HP:0100732)2.49814770
55Bifid tongue (HP:0010297)2.47210450
56Abnormal respiratory epithelium morphology (HP:0012253)2.46451181
57Abnormal respiratory motile cilium morphology (HP:0005938)2.46451181
58Abnormal respiratory motile cilium physiology (HP:0012261)2.44677710
59Abnormality of the salivary glands (HP:0010286)2.44596272
60Hypoplastic female external genitalia (HP:0012815)2.41531094
61Neoplasm of the adrenal cortex (HP:0100641)2.39164923
62Nephronophthisis (HP:0000090)2.39053845
63Pseudobulbar signs (HP:0002200)2.38588085
64Testicular atrophy (HP:0000029)2.38572876
65Vertebral fusion (HP:0002948)2.37795587
66Abnormality of the ileum (HP:0001549)2.36985846
67Cortical dysplasia (HP:0002539)2.34294877
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.32998809
69Drooling (HP:0002307)2.31457648
70Abnormality of the phalanges of the hallux (HP:0010057)2.29884326
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28617822
72Deep palmar crease (HP:0006191)2.28260692
73Renal duplication (HP:0000075)2.28199322
74Oligodactyly (HP:0012165)2.27324916
75Preauricular pit (HP:0004467)2.27007866
76Periauricular skin pits (HP:0100277)2.27007866
77Large earlobe (HP:0009748)2.26662979
78Excessive salivation (HP:0003781)2.26468379
79Duplication of thumb phalanx (HP:0009942)2.25544223
80Preaxial foot polydactyly (HP:0001841)2.25025386
81Abnormality of the labia minora (HP:0012880)2.24893564
82Impulsivity (HP:0100710)2.24307442
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.23157788
84Absent/shortened dynein arms (HP:0200106)2.23157788
85Septo-optic dysplasia (HP:0100842)2.22321276
86Absent radius (HP:0003974)2.21902913
87Missing ribs (HP:0000921)2.20898748
88Pancreatic cysts (HP:0001737)2.20601637
89Enlarged kidneys (HP:0000105)2.20009671
90Abnormality of the pulmonary veins (HP:0011718)2.19353956
91Short 5th finger (HP:0009237)2.18567554
92Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18375641
93Anencephaly (HP:0002323)2.17566770
94Anophthalmia (HP:0000528)2.16961151
95Combined immunodeficiency (HP:0005387)2.15161151
96Nasal polyposis (HP:0100582)2.14935670
97Abnormality of abdominal situs (HP:0011620)2.14662570
98Abdominal situs inversus (HP:0003363)2.14662570
99Tetraplegia (HP:0002445)2.13711850
100Abnormal ciliary motility (HP:0012262)2.13590262
101Abnormal umbilical cord blood vessels (HP:0011403)2.13200011
102Single umbilical artery (HP:0001195)2.13200011
103Abnormality of the fetal cardiovascular system (HP:0010948)2.13200011
104Supernumerary ribs (HP:0005815)2.12886532
105Aplasia involving forearm bones (HP:0009822)2.12177717
106Absent forearm bone (HP:0003953)2.12177717
107Glossoptosis (HP:0000162)2.11756337
108True hermaphroditism (HP:0010459)2.10716095
109Atresia of the external auditory canal (HP:0000413)2.10618074
110Atrophy/Degeneration involving motor neurons (HP:0007373)2.09849758
111Medial flaring of the eyebrow (HP:0010747)2.07636684
112Abnormality of the corticospinal tract (HP:0002492)2.07086026
113Glioma (HP:0009733)2.06216079
114Supernumerary bones of the axial skeleton (HP:0009144)2.05151912
115Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.04526290
116Growth hormone deficiency (HP:0000824)2.04358298
117Anosmia (HP:0000458)2.04213844
118Hypoplasia of the fovea (HP:0007750)2.04089194
119Aplasia/Hypoplasia of the fovea (HP:0008060)2.04089194
120Pachygyria (HP:0001302)1.99091415
121Vaginal atresia (HP:0000148)1.98650448
122Genital tract atresia (HP:0001827)1.95757312
123Rhinitis (HP:0012384)1.95224540
124Abnormality of the pubic bones (HP:0003172)1.93816721
125Abnormal number of incisors (HP:0011064)1.93036713
126Abnormality of the musculature of the hand (HP:0001421)1.92868492
127Severe combined immunodeficiency (HP:0004430)1.92523436
128Selective tooth agenesis (HP:0001592)1.92288767
129T lymphocytopenia (HP:0005403)1.92219503
130Patent foramen ovale (HP:0001655)1.91986985
131Prominent occiput (HP:0000269)1.91405132
132Abnormality of the antihelix (HP:0009738)1.91119313
133Generalized hypotonia (HP:0001290)1.90759235
134Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.90217042
135Horizontal nystagmus (HP:0000666)1.89826335
136Abnormality of the renal medulla (HP:0100957)1.88361415
137Tongue fasciculations (HP:0001308)1.88279783
138Broad thumb (HP:0011304)1.88155266
139Hemivertebrae (HP:0002937)1.88082596
140Hypopigmentation of the fundus (HP:0007894)1.87838964
141Metaphyseal dysplasia (HP:0100255)1.86901309
142Preaxial hand polydactyly (HP:0001177)1.86527540
143Gait imbalance (HP:0002141)1.86349728
144Abnormality of chromosome segregation (HP:0002916)1.86256915
145Cleft eyelid (HP:0000625)1.82915883
146Triphalangeal thumb (HP:0001199)1.82865157
147Hypochromic anemia (HP:0001931)1.82317892
148Nephrogenic diabetes insipidus (HP:0009806)1.81587181
149Lissencephaly (HP:0001339)1.81487976
150Myelomeningocele (HP:0002475)1.80706192
151Impaired vibration sensation in the lower limbs (HP:0002166)1.80657948
152Aqueductal stenosis (HP:0002410)1.79570740
153Narrow forehead (HP:0000341)1.79166512
154Progressive external ophthalmoplegia (HP:0000590)1.78929821
155Skin pits (HP:0100276)1.78485261
156Abnormal rod and cone electroretinograms (HP:0008323)1.78319284
157Increased nuchal translucency (HP:0010880)1.77474008
158Broad-based gait (HP:0002136)1.77414049
159Polymicrogyria (HP:0002126)1.76584900
160Chin dimple (HP:0010751)1.76394820
161Congenital stationary night blindness (HP:0007642)1.76321147
162Premature ovarian failure (HP:0008209)1.76289987
163Stenosis of the external auditory canal (HP:0000402)1.76031174
164Congenital diaphragmatic hernia (HP:0000776)1.75592025
165Malignant neoplasm of the central nervous system (HP:0100836)1.74663909
166Pendular nystagmus (HP:0012043)1.74326189
167Meningocele (HP:0002435)1.73555340
168Aplasia/Hypoplasia of the scapulae (HP:0006713)1.73352730
169Hypoplastic scapulae (HP:0000882)1.73352730
170Myokymia (HP:0002411)1.73318907
171Abnormality of the phalanges of the 5th finger (HP:0004213)1.72991546
172Anal stenosis (HP:0002025)1.72878348
173Colon cancer (HP:0003003)1.72781737
174Horseshoe kidney (HP:0000085)1.72755391
175Hypoplastic labia majora (HP:0000059)1.72315402
176Abnormality of the labia (HP:0000058)1.72202197
177Congenital primary aphakia (HP:0007707)1.72152323
178Microretrognathia (HP:0000308)1.72030156
179Delayed CNS myelination (HP:0002188)1.71942452
180Methylmalonic acidemia (HP:0002912)1.71700942
181Abnormality of the parathyroid morphology (HP:0011766)1.71220910
182Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70247789
183Renal hypoplasia (HP:0000089)1.70048996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.99952379
2GRK64.59567177
3GRK53.74395127
4ACVR1B3.48768510
5TRIM282.96509734
6ADRBK22.88152778
7BCR2.87827739
8STK102.86328253
9BMPR1B2.79948442
10CASK2.76439048
11TTK2.62233595
12TYRO32.61336369
13WNK32.56909500
14ERN12.50611034
15EPHA22.38579747
16SIK32.38293260
17MAP3K102.13123173
18GRK12.13105407
19NUAK12.09367771
20LATS22.03653531
21CDC72.01818172
22MAP3K111.96188982
23CSF1R1.96111621
24CAMKK21.95992489
25GRK71.91799023
26MINK11.89700304
27MARK11.79903622
28EPHB21.78083532
29CDK71.73395452
30MAPK71.72640342
31BUB11.70142182
32TNIK1.64533540
33PAK31.63824152
34MAP3K41.62490353
35ALK1.60103402
36NEK21.56212851
37PAK41.49337391
38WEE11.46298674
39PLK11.39335680
40MAPK131.38190656
41TESK21.37798184
42ERBB41.37661321
43TGFBR21.35204405
44ITK1.23691209
45CDK191.23132925
46WNK11.21702919
47CAMKK11.18800070
48WNK41.18476895
49DYRK1B1.18386072
50RPS6KB21.18106462
51BRAF1.17135348
52CDK41.16283779
53CHEK11.14946337
54CHEK21.14878374
55NTRK21.13605653
56MATK1.11666344
57PINK11.11235591
58MOS1.07542505
59MARK21.07030890
60MAPK151.06418622
61KSR11.05498797
62SRPK11.04342088
63TSSK61.01977051
64AKT31.01584767
65PRKCQ1.01507156
66CAMK40.99302414
67HIPK20.97383900
68SGK2230.96102734
69SGK4940.96102734
70OXSR10.95282585
71CSNK1G20.93710191
72DMPK0.91849164
73MAP4K20.91657451
74CDK30.87650272
75ERBB20.86025284
76DAPK20.84604399
77PRKG20.84213459
78AKT20.84084107
79TXK0.83433400
80CDK20.81051732
81FGFR30.80659238
82MTOR0.80549469
83EPHA40.80237413
84STK110.79596568
85LRRK20.78951404
86PKN10.77435242
87CAMK10.76842237
88SGK20.76112149
89PLK40.75817340
90PNCK0.75631333
91CSK0.75166638
92NTRK30.75054230
93ERBB30.72121306
94MAP3K80.71983917
95MAP2K70.71558564
96BTK0.71379235
97PLK20.71001921
98PBK0.70636201
99BRD40.70586943
100AURKB0.68696641
101MST40.66078425
102MAP2K60.64883537
103PRKCH0.64714459
104AURKA0.63961715
105MKNK20.63121942
106ADRBK10.61727865
107FRK0.61642805
108PRKCI0.60716124
109MAP4K10.58901916
110ATM0.58857481
111PAK10.58523462
112CSNK1E0.58223086
113SIK20.57172117
114FES0.55873530
115PASK0.55286256
116PTK20.53733722
117CSNK1G10.53549094
118PRKCG0.53380499
119MAP3K70.52947054
120ZAK0.52299624
121MKNK10.51763844
122EPHA30.51487613
123NTRK10.51306279
124ATR0.51137311
125MAP3K90.50507738
126EIF2AK20.48984530
127CDK10.47485986
128CSNK1G30.45624159
129TEC0.44976634
130MELK0.42956050
131CAMK1G0.42846180
132CDK50.42008660
133EEF2K0.41860691
134BLK0.41070383
135STK390.39983488
136BRSK20.39629427
137PRKCZ0.38171266
138RPS6KA20.38046928
139DYRK30.38009351
140PRKD20.37476605
141PIM10.35404634
142BRSK10.35202661
143ICK0.34069330
144MAPK100.34007083
145PRKACA0.32862320
146STK30.32196702
147NLK0.31891352
148DYRK20.30234870
149FGFR10.29942975
150GSK3B0.29055118
151BMX0.28474407
152RIPK10.27820717
153MAP2K20.27760845
154MAP2K40.27560424
155MAPK140.26356076
156IGF1R0.24946971
157KDR0.22653730
158TAOK10.22375496
159CDK11A0.22246465
160MAPK10.22245180
161PDGFRA0.21955960
162CDK150.21087490
163STK40.19461678
164LCK0.19145215
165INSR0.18718298
166TGFBR10.17637633
167LATS10.16787791
168DYRK1A0.16740938

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.36767459
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.03913227
3Vitamin B6 metabolism_Homo sapiens_hsa007502.99255796
4RNA transport_Homo sapiens_hsa030132.98200314
5Spliceosome_Homo sapiens_hsa030402.84133930
6DNA replication_Homo sapiens_hsa030302.65847244
7Steroid biosynthesis_Homo sapiens_hsa001002.65522152
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.47637663
9Nicotine addiction_Homo sapiens_hsa050332.46776587
10mRNA surveillance pathway_Homo sapiens_hsa030152.41288961
11Mismatch repair_Homo sapiens_hsa034302.38705265
12Ribosome_Homo sapiens_hsa030102.30401330
13Protein export_Homo sapiens_hsa030602.27136404
14Phototransduction_Homo sapiens_hsa047442.24725825
15Axon guidance_Homo sapiens_hsa043602.22524101
16Graft-versus-host disease_Homo sapiens_hsa053322.12293039
17One carbon pool by folate_Homo sapiens_hsa006702.11001442
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07056203
19Fructose and mannose metabolism_Homo sapiens_hsa000512.06369098
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06006786
21Basal cell carcinoma_Homo sapiens_hsa052172.05596214
22RNA polymerase_Homo sapiens_hsa030201.91222537
23Cell cycle_Homo sapiens_hsa041101.88696199
24Parkinsons disease_Homo sapiens_hsa050121.84740294
25Oxidative phosphorylation_Homo sapiens_hsa001901.82620997
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71964762
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71386825
28Morphine addiction_Homo sapiens_hsa050321.71219902
29Base excision repair_Homo sapiens_hsa034101.70268120
30RNA degradation_Homo sapiens_hsa030181.68046446
31Hedgehog signaling pathway_Homo sapiens_hsa043401.68026307
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67426682
33Cholinergic synapse_Homo sapiens_hsa047251.65978190
34Fanconi anemia pathway_Homo sapiens_hsa034601.63254958
35Hippo signaling pathway_Homo sapiens_hsa043901.62049388
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.59304482
37Homologous recombination_Homo sapiens_hsa034401.54949657
38Thyroid cancer_Homo sapiens_hsa052161.46491540
39Glutamatergic synapse_Homo sapiens_hsa047241.38575175
40GABAergic synapse_Homo sapiens_hsa047271.37252262
41Regulation of autophagy_Homo sapiens_hsa041401.37085842
42mTOR signaling pathway_Homo sapiens_hsa041501.36027421
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34534394
44Olfactory transduction_Homo sapiens_hsa047401.33668372
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27936735
46Collecting duct acid secretion_Homo sapiens_hsa049661.26664008
47Proteasome_Homo sapiens_hsa030501.26525009
48Dopaminergic synapse_Homo sapiens_hsa047281.25557398
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24671823
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24177337
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20143508
52Cardiac muscle contraction_Homo sapiens_hsa042601.20063939
53p53 signaling pathway_Homo sapiens_hsa041151.19742269
54Huntingtons disease_Homo sapiens_hsa050161.19394815
55Nucleotide excision repair_Homo sapiens_hsa034201.18398662
56MicroRNAs in cancer_Homo sapiens_hsa052061.12898576
57Allograft rejection_Homo sapiens_hsa053301.11223902
58Antigen processing and presentation_Homo sapiens_hsa046121.09357370
59Circadian entrainment_Homo sapiens_hsa047131.08742461
60Serotonergic synapse_Homo sapiens_hsa047261.07101269
61T cell receptor signaling pathway_Homo sapiens_hsa046601.05489675
62Wnt signaling pathway_Homo sapiens_hsa043101.04364583
63Pyrimidine metabolism_Homo sapiens_hsa002401.04129815
64Herpes simplex infection_Homo sapiens_hsa051681.02928317
65Colorectal cancer_Homo sapiens_hsa052101.02642540
66Galactose metabolism_Homo sapiens_hsa000521.01891928
67HTLV-I infection_Homo sapiens_hsa051661.01890480
68Arachidonic acid metabolism_Homo sapiens_hsa005901.01609094
69Viral myocarditis_Homo sapiens_hsa054160.99665923
70Basal transcription factors_Homo sapiens_hsa030220.99665681
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99325309
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97842678
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97395601
74Alzheimers disease_Homo sapiens_hsa050100.94376017
75Acute myeloid leukemia_Homo sapiens_hsa052210.93967740
76Pathways in cancer_Homo sapiens_hsa052000.91777395
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91087538
78Propanoate metabolism_Homo sapiens_hsa006400.90109262
79cAMP signaling pathway_Homo sapiens_hsa040240.89380130
80Primary immunodeficiency_Homo sapiens_hsa053400.88549024
81Notch signaling pathway_Homo sapiens_hsa043300.88188317
82Peroxisome_Homo sapiens_hsa041460.87596574
83Chemokine signaling pathway_Homo sapiens_hsa040620.86410826
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83494150
85Adherens junction_Homo sapiens_hsa045200.82602084
86Synaptic vesicle cycle_Homo sapiens_hsa047210.81970903
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81302515
88Apoptosis_Homo sapiens_hsa042100.80138615
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80060537
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79170447
91Type I diabetes mellitus_Homo sapiens_hsa049400.78398954
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.78105163
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.77013704
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76428490
95Rap1 signaling pathway_Homo sapiens_hsa040150.75964177
96Dorso-ventral axis formation_Homo sapiens_hsa043200.73662703
97Linoleic acid metabolism_Homo sapiens_hsa005910.73574840
98Autoimmune thyroid disease_Homo sapiens_hsa053200.73223625
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71348107
100Insulin secretion_Homo sapiens_hsa049110.71084884
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68952358
102Tight junction_Homo sapiens_hsa045300.68376390
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67896566
104Epstein-Barr virus infection_Homo sapiens_hsa051690.67859555
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67159095
106Viral carcinogenesis_Homo sapiens_hsa052030.67019977
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65669475
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65276535
109Gastric acid secretion_Homo sapiens_hsa049710.63390005
110Ether lipid metabolism_Homo sapiens_hsa005650.63196237
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63148697
112Oxytocin signaling pathway_Homo sapiens_hsa049210.62604687
113Non-small cell lung cancer_Homo sapiens_hsa052230.62075197
114Butanoate metabolism_Homo sapiens_hsa006500.62056220
115Proteoglycans in cancer_Homo sapiens_hsa052050.61590440
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61508561
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60720262
118Oocyte meiosis_Homo sapiens_hsa041140.60550296
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60340807
120Caffeine metabolism_Homo sapiens_hsa002320.59360338
121Cocaine addiction_Homo sapiens_hsa050300.58069974
122Non-homologous end-joining_Homo sapiens_hsa034500.57619276
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.57223407
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54273875
125Ras signaling pathway_Homo sapiens_hsa040140.54212858
126Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54149895
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.53503989
128Salmonella infection_Homo sapiens_hsa051320.52737306
129Endometrial cancer_Homo sapiens_hsa052130.52666428
130TGF-beta signaling pathway_Homo sapiens_hsa043500.52341731
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52023283
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51989580
133Ovarian steroidogenesis_Homo sapiens_hsa049130.51855930
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50695552
135Long-term depression_Homo sapiens_hsa047300.50607052
136Pentose phosphate pathway_Homo sapiens_hsa000300.49880465
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48854547
138Alcoholism_Homo sapiens_hsa050340.48720063
139Fatty acid metabolism_Homo sapiens_hsa012120.48294076
140Inositol phosphate metabolism_Homo sapiens_hsa005620.47551657
141VEGF signaling pathway_Homo sapiens_hsa043700.47243063
142Glycerolipid metabolism_Homo sapiens_hsa005610.46268176
143Amphetamine addiction_Homo sapiens_hsa050310.44479461
144Small cell lung cancer_Homo sapiens_hsa052220.44438442
145Hematopoietic cell lineage_Homo sapiens_hsa046400.43561531
146Bladder cancer_Homo sapiens_hsa052190.43379198
147Measles_Homo sapiens_hsa051620.42830874
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42783052
149Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42170107
150Choline metabolism in cancer_Homo sapiens_hsa052310.41516132
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39995814
152Pancreatic cancer_Homo sapiens_hsa052120.39917999
153Prolactin signaling pathway_Homo sapiens_hsa049170.39685814
154Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38949291
155Calcium signaling pathway_Homo sapiens_hsa040200.38524375
156Biosynthesis of amino acids_Homo sapiens_hsa012300.37517394
157Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37443261
158FoxO signaling pathway_Homo sapiens_hsa040680.37252383
159Melanoma_Homo sapiens_hsa052180.36628619
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36573207
161Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31709047
162MAPK signaling pathway_Homo sapiens_hsa040100.31162614
163Cysteine and methionine metabolism_Homo sapiens_hsa002700.30267898
164Jak-STAT signaling pathway_Homo sapiens_hsa046300.29608154
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28725184
166Influenza A_Homo sapiens_hsa051640.27831045
167Melanogenesis_Homo sapiens_hsa049160.27765905

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