EP300

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.74235976
2cytoplasmic mRNA processing body assembly (GO:0033962)4.68586519
3mitotic sister chromatid cohesion (GO:0007064)4.38733052
4nuclear pore complex assembly (GO:0051292)4.35747909
5histone H3-K4 trimethylation (GO:0080182)3.86181174
6regulation of RNA export from nucleus (GO:0046831)3.77440344
7histone H3-K4 methylation (GO:0051568)3.75106511
8nuclear pore organization (GO:0006999)3.74096239
9NLS-bearing protein import into nucleus (GO:0006607)3.50248596
10negative regulation of histone methylation (GO:0031061)3.41149337
11positive regulation of histone deacetylation (GO:0031065)3.40600030
12glucocorticoid receptor signaling pathway (GO:0042921)3.37594201
13negative regulation of erythrocyte differentiation (GO:0045647)3.34945228
14histone H3-K36 demethylation (GO:0070544)3.34733940
15regulation of nucleobase-containing compound transport (GO:0032239)3.18943673
16embryonic process involved in female pregnancy (GO:0060136)3.18925993
17pore complex assembly (GO:0046931)3.17871587
18positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.17209678
19regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.17209678
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.16901400
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.16901400
22regulation of translation, ncRNA-mediated (GO:0045974)3.16901400
23positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.14969621
24regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.14969621
25phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.09943621
26positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.08117449
27histone H3-K9 demethylation (GO:0033169)3.04822898
28response to UV-C (GO:0010225)3.03168385
29regulation of gamma-delta T cell activation (GO:0046643)3.02025668
30regulation of histone H3-K27 methylation (GO:0061085)2.98716027
31response to muramyl dipeptide (GO:0032495)2.98265115
32interkinetic nuclear migration (GO:0022027)2.97770658
33corticosteroid receptor signaling pathway (GO:0031958)2.95375154
34peptidyl-lysine trimethylation (GO:0018023)2.95108977
35histone lysine methylation (GO:0034968)2.93712335
36positive regulation of gene expression, epigenetic (GO:0045815)2.88285910
37regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.85409228
38positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.82336398
39retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79838615
40embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79406243
41negative regulation of cell killing (GO:0031342)2.75521809
42negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.75521809
43histone lysine demethylation (GO:0070076)2.75202955
44positive regulation of mRNA catabolic process (GO:0061014)2.73930430
45cellular extravasation (GO:0045123)2.72608616
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71110891
47RNA stabilization (GO:0043489)2.69967233
48mRNA stabilization (GO:0048255)2.69967233
49positive thymic T cell selection (GO:0045059)2.69896559
50heterochromatin organization (GO:0070828)2.66940195
51hippo signaling (GO:0035329)2.63620528
52definitive hemopoiesis (GO:0060216)2.62617447
53peptidyl-threonine phosphorylation (GO:0018107)2.62324929
54regulation of mRNA catabolic process (GO:0061013)2.62131043
553-UTR-mediated mRNA stabilization (GO:0070935)2.58012317
56embryonic camera-type eye morphogenesis (GO:0048596)2.57786053
57histone H3-K9 methylation (GO:0051567)2.55637297
58protein targeting to Golgi (GO:0000042)2.53459708
59histone demethylation (GO:0016577)2.52896173
60regulation of histone H3-K9 methylation (GO:0051570)2.51451957
61histone H3-K9 modification (GO:0061647)2.51217515
62regulation of chromatin binding (GO:0035561)2.50982129
63regulation of sister chromatid cohesion (GO:0007063)2.50668939
64histone deubiquitination (GO:0016578)2.50383193
65insulin-like growth factor receptor signaling pathway (GO:0048009)2.50153127
66positive regulation of SMAD protein import into nucleus (GO:0060391)2.49675491
67histone H4-K16 acetylation (GO:0043984)2.49345517
68stress granule assembly (GO:0034063)2.48989831
69negative regulation of myotube differentiation (GO:0010832)2.48899179
70response to laminar fluid shear stress (GO:0034616)2.48870121
71positive regulation of gamma-delta T cell activation (GO:0046645)2.46721402
72positive regulation of granulocyte differentiation (GO:0030854)2.46284243
73negative thymic T cell selection (GO:0045060)2.46040967
74negative regulation of gene expression, epigenetic (GO:0045814)2.45778906
75intracellular estrogen receptor signaling pathway (GO:0030520)2.45043841
76regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.42775919
77establishment of protein localization to Golgi (GO:0072600)2.42645402
78monoubiquitinated protein deubiquitination (GO:0035520)2.41822835
79paraxial mesoderm development (GO:0048339)2.41762871
80regulation of ARF protein signal transduction (GO:0032012)2.41157730
81histone methylation (GO:0016571)2.40966277
82heart morphogenesis (GO:0003007)2.40471326
83peptidyl-threonine modification (GO:0018210)2.40195299
84positive regulation of mitotic sister chromatid separation (GO:1901970)2.40168476
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.40168476
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.40168476
87positive regulation of Rap GTPase activity (GO:0032854)2.39946293
88regulation of protein polyubiquitination (GO:1902914)2.35936448
89protein K48-linked deubiquitination (GO:0071108)2.35517398
90detection of molecule of bacterial origin (GO:0032490)2.34880825
91regulation of gamma-delta T cell differentiation (GO:0045586)2.33283585
92macrophage activation involved in immune response (GO:0002281)2.32981853
93negative T cell selection (GO:0043383)2.32023832
94negative regulation of glial cell proliferation (GO:0060253)2.31124119
95B cell receptor signaling pathway (GO:0050853)2.30581289
96regulation of B cell receptor signaling pathway (GO:0050855)2.30373771
97peptidyl-lysine dimethylation (GO:0018027)2.30344887
98regulation of NFAT protein import into nucleus (GO:0051532)2.30254910
99peptidyl-lysine methylation (GO:0018022)2.29885064
100T cell selection (GO:0045058)2.28630382
101negative regulation of DNA repair (GO:0045738)2.28494610
102positive regulation of protein deacetylation (GO:0090312)2.28310873
103chromatin assembly (GO:0031497)2.27702742
104DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.27496805
105regulation of DNA endoreduplication (GO:0032875)2.25650679
106response to peptidoglycan (GO:0032494)2.23038453
107coronary vasculature morphogenesis (GO:0060977)2.22754444
108negative regulation of cAMP-mediated signaling (GO:0043951)2.22456292
109gene silencing (GO:0016458)2.22444428
110dosage compensation (GO:0007549)2.22307713
111thymic T cell selection (GO:0045061)2.21482834
112regulation of histone methylation (GO:0031060)2.20894979
113regulation of interferon-beta biosynthetic process (GO:0045357)2.20641381
114embryonic hemopoiesis (GO:0035162)2.20473155
115antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.20057678
116positive T cell selection (GO:0043368)2.19656356
117positive regulation of RNA splicing (GO:0033120)2.18864250
118protein demethylation (GO:0006482)2.18546396
119protein dealkylation (GO:0008214)2.18546396
120regulation of histone H3-K4 methylation (GO:0051569)2.18259386
121cortical actin cytoskeleton organization (GO:0030866)2.16866825
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.16774157
123trophectodermal cell differentiation (GO:0001829)2.16605723
124negative regulation of histone modification (GO:0031057)2.15706850
125head development (GO:0060322)2.15573533
126neural tube closure (GO:0001843)2.15115365
127chromatin silencing (GO:0006342)2.14989908
128gene silencing by RNA (GO:0031047)2.14367416
129mitotic chromosome condensation (GO:0007076)2.13896172
130negative regulation of chromatin modification (GO:1903309)2.13425728
131regulation of histone deacetylation (GO:0031063)2.13086535
132positive regulation by symbiont of host defense response (GO:0052509)2.12562157
133modulation by symbiont of host defense response (GO:0052031)2.12562157
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.12562157
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.12562157
136modulation by symbiont of host immune response (GO:0052553)2.12562157

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.51495199
2E2F7_22180533_ChIP-Seq_HELA_Human4.34470769
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10969978
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.95032685
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.48855767
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05527608
7MYC_22102868_ChIP-Seq_BL_Human3.01834101
8TCF7_22412390_ChIP-Seq_EML_Mouse2.46569331
9KDM2B_26808549_Chip-Seq_DND41_Human2.32773750
10* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.28343788
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26838030
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.18681433
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.07104352
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01837772
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00562887
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97710705
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96817964
18VDR_21846776_ChIP-Seq_THP-1_Human1.94180244
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.92032704
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91289413
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85185012
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79826358
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.78063509
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.78063509
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.78063509
26KDM2B_26808549_Chip-Seq_JURKAT_Human1.77345966
27SCL_19346495_ChIP-Seq_HPC-7_Human1.73849061
28FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.72835498
29* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72809499
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72138755
31RUNX_20019798_ChIP-Seq_JUKART_Human1.67523227
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66910726
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65095696
34SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63591442
35UTX_26944678_Chip-Seq_JUKART_Human1.59769751
36MAF_26560356_Chip-Seq_TH1_Human1.56146476
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56085186
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51956007
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49970253
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48206382
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.45938874
42SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44808524
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.44203341
44SPI1_23127762_ChIP-Seq_K562_Human1.42605004
45KDM2B_26808549_Chip-Seq_K562_Human1.41754588
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41612474
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.41229717
48* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40947885
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40874921
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39605457
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39521535
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39484916
53MYB_26560356_Chip-Seq_TH1_Human1.38402951
54VDR_24763502_ChIP-Seq_THP-1_Human1.34891606
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.34545443
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32462570
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.30727083
58MYB_26560356_Chip-Seq_TH2_Human1.29744738
59* IRF8_27001747_Chip-Seq_BMDM_Mouse1.29509025
60* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28421296
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28287861
62GATA1_22025678_ChIP-Seq_K562_Human1.28000982
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26581857
64GATA1_19941826_ChIP-Seq_K562_Human1.26302071
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25573915
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24830997
67GATA2_19941826_ChIP-Seq_K562_Human1.23739551
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22304049
69NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22288850
70E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22145280
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22043832
72TP53_16413492_ChIP-PET_HCT116_Human1.21891482
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.20578597
74DROSHA_22980978_ChIP-Seq_HELA_Human1.18485853
75AR_21572438_ChIP-Seq_LNCaP_Human1.17321558
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16841603
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16841603
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.16181628
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15476129
80NCOR1_26117541_ChIP-Seq_K562_Human1.15338862
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14358380
82* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12825845
83CIITA_25753668_ChIP-Seq_RAJI_Human1.09817629
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.08326570
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08291284
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07619786
87EZH2_22144423_ChIP-Seq_EOC_Human1.07440446
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07413178
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06825125
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06667694
91PU_27001747_Chip-Seq_BMDM_Mouse1.05362952
92BRD4_25478319_ChIP-Seq_HGPS_Human1.05008267
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04776727
94GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03182660
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02574713
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02482396
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.02149288
98GATA6_25053715_ChIP-Seq_YYC3_Human1.02070352
99NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00434498
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00009810
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99944718
102RUNX1_27514584_Chip-Seq_MCF-7_Human0.99787363
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.99425326
104VDR_24787735_ChIP-Seq_THP-1_Human0.98914842
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98834169
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98281543
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.98082977
108AHR_22903824_ChIP-Seq_MCF-7_Human0.96091568
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95290514
110MAF_26560356_Chip-Seq_TH2_Human0.95144810
111HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94992265
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94985186
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94483814
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94357359
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93134341
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93068331
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92631741
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91888989
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90942017
120RUNX1_22412390_ChIP-Seq_EML_Mouse0.90809954
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90695148
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90263048
123CREB1_26743006_Chip-Seq_LNCaP_Human0.89488139
124SMAD_19615063_ChIP-ChIP_OVARY_Human0.89446843
125GATA3_27048872_Chip-Seq_THYMUS_Human0.88268694
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.88156113
127PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87095321

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005076_abnormal_cell_differentiation3.79390598
2MP0000569_abnormal_digit_pigmentation3.46981770
3MP0005409_darkened_coat_color2.89494417
4MP0010352_gastrointestinal_tract_polyps2.80122903
5MP0003300_gastrointestinal_ulcer2.75556015
6MP0009278_abnormal_bone_marrow2.61150969
7MP0003705_abnormal_hypodermis_morpholog2.44312087
8MP0008961_abnormal_basal_metabolism2.18890437
9MP0003303_peritoneal_inflammation2.17775618
10MP0010307_abnormal_tumor_latency2.11886414
11MP0008057_abnormal_DNA_replication2.10457211
12MP0004808_abnormal_hematopoietic_stem1.93324136
13MP0003656_abnormal_erythrocyte_physiolo1.88601298
14MP0003436_decreased_susceptibility_to1.84707313
15MP0005451_abnormal_body_composition1.78835637
16MP0003566_abnormal_cell_adhesion1.75905191
17MP0005310_abnormal_salivary_gland1.75347808
18MP0002396_abnormal_hematopoietic_system1.74578272
19* MP0000733_abnormal_muscle_development1.69893108
20MP0008260_abnormal_autophagy1.69643293
21MP0003045_fibrosis1.67844505
22MP0004264_abnormal_extraembryonic_tissu1.63862523
23MP0002877_abnormal_melanocyte_morpholog1.63217991
24MP0004185_abnormal_adipocyte_glucose1.62629715
25MP0003890_abnormal_embryonic-extraembry1.53226020
26MP0004381_abnormal_hair_follicle1.51082211
27* MP0002925_abnormal_cardiovascular_devel1.48903110
28* MP0003984_embryonic_growth_retardation1.48889199
29* MP0002088_abnormal_embryonic_growth/wei1.47921725
30MP0003091_abnormal_cell_migration1.47052166
31* MP0002086_abnormal_extraembryonic_tissu1.45986709
32MP0004197_abnormal_fetal_growth/weight/1.45678293
33MP0010234_abnormal_vibrissa_follicle1.44278805
34MP0001849_ear_inflammation1.41576144
35* MP0001672_abnormal_embryogenesis/_devel1.39414453
36* MP0005380_embryogenesis_phenotype1.39414453
37MP0001915_intracranial_hemorrhage1.38677971
38* MP0002084_abnormal_developmental_patter1.38472384
39MP0001545_abnormal_hematopoietic_system1.37431393
40MP0005397_hematopoietic_system_phenotyp1.37431393
41MP0003111_abnormal_nucleus_morphology1.37290288
42MP0003121_genomic_imprinting1.37029187
43MP0009703_decreased_birth_body1.33478191
44* MP0000350_abnormal_cell_proliferation1.31550197
45MP0000428_abnormal_craniofacial_morphol1.31356612
46MP0003828_pulmonary_edema1.31094600
47MP0003567_abnormal_fetal_cardiomyocyte1.27853235
48MP0001835_abnormal_antigen_presentation1.27250281
49MP0003077_abnormal_cell_cycle1.27104109
50* MP0002085_abnormal_embryonic_tissue1.25522434
51MP0002998_abnormal_bone_remodeling1.25214541
52MP0001800_abnormal_humoral_immune1.25054729
53* MP0000703_abnormal_thymus_morphology1.23238227
54MP0003935_abnormal_craniofacial_develop1.22359793
55MP0003787_abnormal_imprinting1.20578897
56* MP0010630_abnormal_cardiac_muscle1.18866597
57MP0001790_abnormal_immune_system1.18592446
58MP0005387_immune_system_phenotype1.18592446
59* MP0001730_embryonic_growth_arrest1.18337547
60MP0009115_abnormal_fat_cell1.17966703
61MP0002653_abnormal_ependyma_morphology1.14225928
62* MP0001697_abnormal_embryo_size1.12687828
63MP0002009_preneoplasia1.11554233
64* MP0002398_abnormal_bone_marrow1.10977965
65MP0001851_eye_inflammation1.10822606
66MP0000767_abnormal_smooth_muscle1.10462263
67MP0005023_abnormal_wound_healing1.08877546
68MP0002419_abnormal_innate_immunity1.08843803
69MP0010094_abnormal_chromosome_stability1.07835492
70MP0001293_anophthalmia1.06962452
71MP0010678_abnormal_skin_adnexa1.05987972
72MP0002092_abnormal_eye_morphology1.05735184
73* MP0000266_abnormal_heart_morphology1.04653804
74MP0009672_abnormal_birth_weight1.04310162
75MP0000383_abnormal_hair_follicle1.04225643
76MP0002723_abnormal_immune_serum1.04163098
77MP0003183_abnormal_peptide_metabolism1.02760777
78MP0005257_abnormal_intraocular_pressure1.00625005
79MP0005248_abnormal_Harderian_gland1.00195566
80MP0000003_abnormal_adipose_tissue0.97758096
81* MP0000432_abnormal_head_morphology0.97495022
82MP0002452_abnormal_antigen_presenting0.97332928
83MP0002928_abnormal_bile_duct0.97187710
84* MP0001784_abnormal_fluid_regulation0.96517953
85MP0003172_abnormal_lysosome_physiology0.96462178
86MP0004947_skin_inflammation0.95181996
87* MP0002166_altered_tumor_susceptibility0.94257888
88MP0005375_adipose_tissue_phenotype0.93068962
89MP0005000_abnormal_immune_tolerance0.91909659
90MP0003763_abnormal_thymus_physiology0.91909465
91* MP0002429_abnormal_blood_cell0.91458605
92MP0003448_altered_tumor_morphology0.89363667
93MP0004130_abnormal_muscle_cell0.89310335
94* MP0003115_abnormal_respiratory_system0.88197924
95MP0008877_abnormal_DNA_methylation0.86902018
96MP0009053_abnormal_anal_canal0.86773505
97MP0000685_abnormal_immune_system0.86706209
98* MP0002697_abnormal_eye_size0.86203749
99* MP0002722_abnormal_immune_system0.86199772
100MP0001348_abnormal_lacrimal_gland0.85832952
101MP0008007_abnormal_cellular_replicative0.85691169
102MP0001879_abnormal_lymphatic_vessel0.85410434
103MP0005025_abnormal_response_to0.85270924
104MP0001873_stomach_inflammation0.85069152
105MP0005666_abnormal_adipose_tissue0.84933186
106MP0002405_respiratory_system_inflammati0.84152432
107MP0000470_abnormal_stomach_morphology0.83780281
108MP0003385_abnormal_body_wall0.83536582
109* MP0000716_abnormal_immune_system0.83497512
110MP0003943_abnormal_hepatobiliary_system0.83276432
111MP0005623_abnormal_meninges_morphology0.83095843
112* MP0002080_prenatal_lethality0.83016127
113MP0008995_early_reproductive_senescence0.82546393
114MP0004233_abnormal_muscle_weight0.81958096
115MP0000689_abnormal_spleen_morphology0.81513978
116MP0003453_abnormal_keratinocyte_physiol0.81491451
117MP0003724_increased_susceptibility_to0.81020915
118MP0002420_abnormal_adaptive_immunity0.80154012
119* MP0001614_abnormal_blood_vessel0.79985583
120MP0001819_abnormal_immune_cell0.79153876
121MP0003878_abnormal_ear_physiology0.78312166
122MP0005377_hearing/vestibular/ear_phenot0.78312166
123MP0002249_abnormal_larynx_morphology0.77267145
124MP0004510_myositis0.76735254
125* MP0005621_abnormal_cell_physiology0.76118066
126MP0002138_abnormal_hepatobiliary_system0.73835405
127MP0002254_reproductive_system_inflammat0.71911484
128MP0002168_other_aberrant_phenotype0.71562780
129MP0009931_abnormal_skin_appearance0.70075162
130MP0009333_abnormal_splenocyte_physiolog0.68106437
131MP0005275_abnormal_skin_tensile0.67690941
132MP0002796_impaired_skin_barrier0.66511727

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.52660767
2Urethral obstruction (HP:0000796)3.41184357
3Obstructive sleep apnea (HP:0002870)3.33009060
4Macroorchidism (HP:0000053)3.30031792
5Short 4th metacarpal (HP:0010044)3.20928706
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.20928706
7Volvulus (HP:0002580)3.17738189
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.02426255
9* Long eyelashes (HP:0000527)2.93494216
10Cerebral aneurysm (HP:0004944)2.80169631
11Trigonocephaly (HP:0000243)2.73685630
12Neonatal hypoglycemia (HP:0001998)2.71702575
13Abnormality of the columella (HP:0009929)2.61467502
14Heterotopia (HP:0002282)2.60463486
15Anal stenosis (HP:0002025)2.52365729
16Shallow orbits (HP:0000586)2.49863193
17Broad face (HP:0000283)2.41022297
18Spontaneous hematomas (HP:0007420)2.38409534
19* Narrow palate (HP:0000189)2.36992774
20Hyperacusis (HP:0010780)2.23038199
21Overgrowth (HP:0001548)2.22027523
22Abnormality of incisor morphology (HP:0011063)2.21309985
23Abnormality of the 4th metacarpal (HP:0010012)2.21130010
24Supernumerary ribs (HP:0005815)2.16911878
25Abnormality of the nasal septum (HP:0000419)2.16098964
26Neoplasm of the oral cavity (HP:0100649)2.14390234
27Depressed nasal tip (HP:0000437)2.13428641
28Increased nuchal translucency (HP:0010880)2.12986049
29Ectopic kidney (HP:0000086)2.12802500
30Obsessive-compulsive behavior (HP:0000722)2.10010731
31Abnormal hair whorl (HP:0010721)2.08417585
32Eczematoid dermatitis (HP:0000976)2.08277705
33Hematochezia (HP:0002573)2.07920058
34Truncal obesity (HP:0001956)2.07001154
35Lip pit (HP:0100267)2.06396466
36Absent frontal sinuses (HP:0002688)2.05064760
37Germ cell neoplasia (HP:0100728)2.04817887
38Flat acetabular roof (HP:0003180)2.04554530
39Aortic aneurysm (HP:0004942)2.02243989
40Limited elbow extension (HP:0001377)2.02084819
41Hepatoblastoma (HP:0002884)2.00686200
42Deviation of the thumb (HP:0009603)2.00234780
43Skull defect (HP:0001362)1.99116992
44Astrocytoma (HP:0009592)1.97616252
45Abnormality of the astrocytes (HP:0100707)1.97616252
46Abnormality of the phalanges of the hallux (HP:0010057)1.97264838
47Autoimmune thrombocytopenia (HP:0001973)1.95356721
48Abnormality of the aortic arch (HP:0012303)1.95331184
49Hyperkalemia (HP:0002153)1.91540943
50Low anterior hairline (HP:0000294)1.91136309
51* Prominent nose (HP:0000448)1.90702445
52Proximal placement of thumb (HP:0009623)1.90449853
53Hypoplastic labia majora (HP:0000059)1.88436984
54Disproportionate tall stature (HP:0001519)1.86895058
55Vertebral arch anomaly (HP:0008438)1.86713291
56Increased density of long bones (HP:0006392)1.86319641
57Skin tags (HP:0010609)1.84943009
58Gingivitis (HP:0000230)1.83011113
59Recurrent viral infections (HP:0004429)1.82847911
60Diastasis recti (HP:0001540)1.82553778
61Ependymoma (HP:0002888)1.82490454
62Bronchomalacia (HP:0002780)1.81629398
63Deep palmar crease (HP:0006191)1.80498427
64Genetic anticipation (HP:0003743)1.80215153
65Cutis marmorata (HP:0000965)1.80002332
66Thick eyebrow (HP:0000574)1.79584980
67Abnormality of the thoracic spine (HP:0100711)1.79456105
68Ulnar bowing (HP:0003031)1.79377154
69Midline defect of the nose (HP:0004122)1.78644763
70Abnormality of the parietal bone (HP:0002696)1.78324528
71Laryngomalacia (HP:0001601)1.77997595
72Hypoplastic ischia (HP:0003175)1.77719175
73Slow saccadic eye movements (HP:0000514)1.77484223
74Mitral valve prolapse (HP:0001634)1.77199899
75Sparse lateral eyebrow (HP:0005338)1.76970981
76Syringomyelia (HP:0003396)1.75882421
77Spinal cord lesions (HP:0100561)1.75882421
78Deep philtrum (HP:0002002)1.75623622
79Abnormality of the distal phalanx of the thumb (HP:0009617)1.74108267
80Pseudobulbar signs (HP:0002200)1.73290374
81Tapered finger (HP:0001182)1.73164402
82Recurrent bacterial skin infections (HP:0005406)1.72873462
83Hypoplasia of the maxilla (HP:0000327)1.72474909
84Spondylolisthesis (HP:0003302)1.71260491
85Aneurysm (HP:0002617)1.70945316
86Acute myeloid leukemia (HP:0004808)1.70826973
87Smooth philtrum (HP:0000319)1.69359648
88Viral hepatitis (HP:0006562)1.69150517
89Subacute progressive viral hepatitis (HP:0006572)1.69030674
90Sandal gap (HP:0001852)1.69021120
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68354203
92Aqueductal stenosis (HP:0002410)1.67959017
93Supernumerary bones of the axial skeleton (HP:0009144)1.67566957
94Dislocated radial head (HP:0003083)1.67141241
95Abnormality of the labia majora (HP:0012881)1.66601210
96* Broad thumb (HP:0011304)1.66378747
97Abnormality of the humeroradial joint (HP:0100744)1.65584287
98Oligodontia (HP:0000677)1.65038848
99Elfin facies (HP:0004428)1.64668303
100Colitis (HP:0002583)1.64532994
101Thoracic kyphosis (HP:0002942)1.64419089
102Abnormality of the radial head (HP:0003995)1.64273112
103Abnormal number of incisors (HP:0011064)1.64051465
104Long palpebral fissure (HP:0000637)1.61279620
105Glioma (HP:0009733)1.61113526
106High pitched voice (HP:0001620)1.60673523
107Renal duplication (HP:0000075)1.59895557
108Renovascular hypertension (HP:0100817)1.59843483
109Abnormal delayed hypersensitivity skin test (HP:0002963)1.59176037
110Persistence of primary teeth (HP:0006335)1.59094127
111Abnormality of the intervertebral disk (HP:0005108)1.57273661
112Intestinal fistula (HP:0100819)1.57254752
113Large earlobe (HP:0009748)1.56577117
114Papillary thyroid carcinoma (HP:0002895)1.55970052
115Segmental peripheral demyelination/remyelination (HP:0003481)1.55958517
116Gastrointestinal infarctions (HP:0005244)1.55632640
117Broad palm (HP:0001169)1.55198624
118Rectal prolapse (HP:0002035)1.55024094
119Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54866609
120Onion bulb formation (HP:0003383)1.54709436
121Precocious puberty (HP:0000826)1.54553684
122Recurrent fungal infections (HP:0002841)1.53772452
123Abnormality of the epiphyses of the hand (HP:0005924)1.53556911
124Enlarged penis (HP:0000040)1.53154043
125Tracheomalacia (HP:0002779)1.52417447
126Bicuspid aortic valve (HP:0001647)1.52097225
127Sporadic (HP:0003745)1.51718051
128Abnormality of chromosome segregation (HP:0002916)1.50431665
129Cellulitis (HP:0100658)1.50159276
130Increased IgE level (HP:0003212)1.50085417
131Ureteral obstruction (HP:0006000)1.49944097
132Impulsivity (HP:0100710)1.49654738
133Dysmetric saccades (HP:0000641)1.48457762
134Genu recurvatum (HP:0002816)1.48202507
135Acute lymphatic leukemia (HP:0006721)1.47536873
136Metaphyseal cupping (HP:0003021)1.47001208
137Short phalanx of the thumb (HP:0009660)1.46706207
138Abnormality of the ischium (HP:0003174)1.46388487
139Abnormality of the incisor (HP:0000676)1.44948439
140Advanced eruption of teeth (HP:0006288)1.44698902
141Thyroiditis (HP:0100646)1.44564823
142Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.43898730
143Broad metatarsal (HP:0001783)1.43304484
144Chin dimple (HP:0010751)1.43170714
145Joint laxity (HP:0001388)1.42965974
146Preauricular skin tag (HP:0000384)1.42727716
147Prominent occiput (HP:0000269)1.42561481
148Recurrent abscess formation (HP:0002722)1.42464598
149Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.41597415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.61171461
2BRD42.92044311
3PRPF4B2.90607226
4LATS12.77246308
5MAP3K102.60515456
6ICK2.06640184
7EEF2K2.00017175
8DMPK1.93646700
9SMG11.89481874
10MAP4K11.88800339
11RIPK11.86324187
12STK101.83399838
13AKT31.73755562
14MTOR1.70021108
15RIPK41.67891245
16SIK21.56127519
17TTN1.55269031
18CDC71.50417947
19SIK11.47457588
20NLK1.45615628
21FGFR31.44185166
22BMX1.42976332
23STK31.42959696
24NEK21.39480040
25CDK91.39459771
26CDK61.38773388
27TRIB31.38355817
28ERN11.34032003
29PTK61.33579459
30PKN21.31781474
31FGFR21.31227896
32PDGFRA1.30495156
33BLK1.25243755
34PDGFRB1.24361290
35SGK2231.19273810
36SGK4941.19273810
37MAP2K31.16546781
38TGFBR21.11808721
39JAK11.10153862
40TIE11.09043284
41TNK21.08977295
42MAP3K131.08568536
43ALK1.08129574
44SGK31.07273707
45EPHB11.06335528
46CDK41.03229602
47WNK11.02110552
48STK41.01365528
49TAOK31.01056983
50* CAMK1G1.00169233
51IRAK10.99677345
52CDC42BPA0.93500971
53ITK0.93191810
54MAP3K140.93088405
55CHUK0.92811673
56IRAK20.92550634
57MELK0.88375623
58MARK30.86860272
59YES10.86525920
60HCK0.85993312
61CSK0.84620396
62JAK30.83735962
63IKBKE0.83043272
64CHEK10.81424194
65PNCK0.80919195
66IRAK40.79670536
67TYK20.78794022
68ZAP700.78735629
69ATR0.78036657
70HIPK20.78036022
71MARK20.76540951
72* CAMK1D0.75847451
73FGFR40.75775543
74TYRO30.75678972
75RPS6KA20.75280703
76PRKD20.75066162
77MAP3K70.74970932
78CSF1R0.74362791
79FGFR10.74027235
80CDK70.73993037
81* ATM0.73501822
82RPS6KL10.73054343
83RPS6KC10.73054343
84NUAK10.69307885
85PRKCH0.66836816
86GRK60.65789954
87TAOK10.65375047
88PTK20.64630886
89PAK20.63929085
90SCYL20.63923628
91CDK20.63789536
92PIM10.63739127
93CSNK1D0.63679421
94MAP3K10.62984316
95RPS6KA60.62613769
96TRPM70.60933863
97MAPK100.60248430
98MAPK140.60023073
99SGK20.59487428
100CHEK20.57402918
101MAP3K20.55563351
102FES0.54240748
103SYK0.53862410
104EGFR0.53773348
105* MAPK10.53396632
106ERBB20.53273291
107MAP3K30.53109850
108MKNK20.52165943
109TEC0.52018835
110EPHA30.51674042
111STK110.51228579
112LRRK20.50725784
113CDK10.50578389
114GSK3B0.49862116
115BTK0.49640879
116PRKDC0.49310216
117SGK10.49293250
118RPS6KA10.49285120
119MAP3K80.48695712
120FGR0.48008648
121PDK10.47975345
122MAPK70.47143678
123KSR20.46994523
124PAK40.46202667
125STK380.45809749
126TTK0.45257797
127RET0.44922448
128JAK20.44859243
129CLK10.44717550
130MAPK80.44528219
131LCK0.43836976
132SIK30.43595856
133RPS6KA40.41988917
134PRKD10.41753886
135* AKT10.40851617

Predicted pathways (KEGG)

RankGene SetZ-score
1Lysine degradation_Homo sapiens_hsa003102.10478965
2Chronic myeloid leukemia_Homo sapiens_hsa052201.71824000
3B cell receptor signaling pathway_Homo sapiens_hsa046621.69440326
4Dorso-ventral axis formation_Homo sapiens_hsa043201.69310669
5mTOR signaling pathway_Homo sapiens_hsa041501.55059302
6* MicroRNAs in cancer_Homo sapiens_hsa052061.53417310
7* Adherens junction_Homo sapiens_hsa045201.52420077
8* Notch signaling pathway_Homo sapiens_hsa043301.46098092
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43522422
10Osteoclast differentiation_Homo sapiens_hsa043801.38734227
11Small cell lung cancer_Homo sapiens_hsa052221.37631534
12Proteoglycans in cancer_Homo sapiens_hsa052051.36956553
13Thyroid cancer_Homo sapiens_hsa052161.35545634
14* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35155572
15Type II diabetes mellitus_Homo sapiens_hsa049301.33374773
16Viral myocarditis_Homo sapiens_hsa054161.32409327
17Pancreatic cancer_Homo sapiens_hsa052121.29258128
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.27647291
19Non-small cell lung cancer_Homo sapiens_hsa052231.24160763
20Acute myeloid leukemia_Homo sapiens_hsa052211.20253828
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.19486605
22Basal cell carcinoma_Homo sapiens_hsa052171.19466506
23T cell receptor signaling pathway_Homo sapiens_hsa046601.18659404
24Primary immunodeficiency_Homo sapiens_hsa053401.18405527
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.16618158
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14987722
27Colorectal cancer_Homo sapiens_hsa052101.14211297
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13570058
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13405287
30Endometrial cancer_Homo sapiens_hsa052131.11828265
31Leishmaniasis_Homo sapiens_hsa051401.11115487
32Focal adhesion_Homo sapiens_hsa045101.10375585
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09114518
34Toxoplasmosis_Homo sapiens_hsa051451.07967444
35Glioma_Homo sapiens_hsa052141.07477838
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07281462
37* Renal cell carcinoma_Homo sapiens_hsa052111.06036298
38Insulin resistance_Homo sapiens_hsa049311.04955921
39* HTLV-I infection_Homo sapiens_hsa051661.03729941
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.03526678
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03037884
42* Prostate cancer_Homo sapiens_hsa052151.02617495
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02105425
44GnRH signaling pathway_Homo sapiens_hsa049121.01934140
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99773769
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98385776
47Hepatitis C_Homo sapiens_hsa051600.97720897
48Antigen processing and presentation_Homo sapiens_hsa046120.97635086
49Chemokine signaling pathway_Homo sapiens_hsa040620.97571615
50* Hepatitis B_Homo sapiens_hsa051610.96855289
51mRNA surveillance pathway_Homo sapiens_hsa030150.95041908
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93255832
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92947011
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92648300
55Platelet activation_Homo sapiens_hsa046110.92285234
56* Viral carcinogenesis_Homo sapiens_hsa052030.92177886
57* Herpes simplex infection_Homo sapiens_hsa051680.91881244
58Measles_Homo sapiens_hsa051620.90839224
59* Pathways in cancer_Homo sapiens_hsa052000.90621343
60Hippo signaling pathway_Homo sapiens_hsa043900.89397200
61* FoxO signaling pathway_Homo sapiens_hsa040680.87392302
62Estrogen signaling pathway_Homo sapiens_hsa049150.87029080
63Choline metabolism in cancer_Homo sapiens_hsa052310.85854641
64TNF signaling pathway_Homo sapiens_hsa046680.85544595
65ErbB signaling pathway_Homo sapiens_hsa040120.84946908
66Hematopoietic cell lineage_Homo sapiens_hsa046400.84395892
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83545077
68Malaria_Homo sapiens_hsa051440.83302025
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81830341
70Hedgehog signaling pathway_Homo sapiens_hsa043400.81175219
71VEGF signaling pathway_Homo sapiens_hsa043700.81131720
72Nitrogen metabolism_Homo sapiens_hsa009100.80258312
73Rap1 signaling pathway_Homo sapiens_hsa040150.80243260
74MAPK signaling pathway_Homo sapiens_hsa040100.80153143
75Inositol phosphate metabolism_Homo sapiens_hsa005620.78626158
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78299179
77* Jak-STAT signaling pathway_Homo sapiens_hsa046300.77094416
78* Cell cycle_Homo sapiens_hsa041100.76506335
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.76431101
80Prolactin signaling pathway_Homo sapiens_hsa049170.76256426
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76061693
82Dilated cardiomyopathy_Homo sapiens_hsa054140.75846938
83Fatty acid biosynthesis_Homo sapiens_hsa000610.75775388
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.74931806
85Amoebiasis_Homo sapiens_hsa051460.74835795
86* TGF-beta signaling pathway_Homo sapiens_hsa043500.74619098
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74475512
88ECM-receptor interaction_Homo sapiens_hsa045120.73949781
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.73856919
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73031260
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.71162321
92Apoptosis_Homo sapiens_hsa042100.70953735
93* Wnt signaling pathway_Homo sapiens_hsa043100.70895078
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70870068
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70241560
96* Influenza A_Homo sapiens_hsa051640.69911687
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69487857
98AMPK signaling pathway_Homo sapiens_hsa041520.69474643
99* HIF-1 signaling pathway_Homo sapiens_hsa040660.69184444
100* Long-term potentiation_Homo sapiens_hsa047200.69017789
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68365630
102Circadian rhythm_Homo sapiens_hsa047100.67537749
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.67113372
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66687369
105Cholinergic synapse_Homo sapiens_hsa047250.65357110
106Insulin signaling pathway_Homo sapiens_hsa049100.63967845
107Long-term depression_Homo sapiens_hsa047300.63859323
108Staphylococcus aureus infection_Homo sapiens_hsa051500.62906924
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62277351
110Bladder cancer_Homo sapiens_hsa052190.61328219
111Endocytosis_Homo sapiens_hsa041440.60477514
112Melanoma_Homo sapiens_hsa052180.60343314
113* Tuberculosis_Homo sapiens_hsa051520.56282499
114p53 signaling pathway_Homo sapiens_hsa041150.55351220
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55344041
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54599324
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54595867
118Ras signaling pathway_Homo sapiens_hsa040140.54045696
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.49569846

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