EP400

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.65220763
2mitotic sister chromatid cohesion (GO:0007064)5.34024110
3nuclear pore organization (GO:0006999)5.01629018
4pre-miRNA processing (GO:0031054)4.39184711
5pore complex assembly (GO:0046931)4.27576285
6piRNA metabolic process (GO:0034587)4.24320697
7regulation of histone H3-K27 methylation (GO:0061085)4.16170523
8gene silencing by RNA (GO:0031047)4.03638028
9regulation of RNA export from nucleus (GO:0046831)4.01051235
10negative regulation of histone methylation (GO:0031061)3.99877835
11cytoplasmic mRNA processing body assembly (GO:0033962)3.95685610
12regulation of histone H3-K9 methylation (GO:0051570)3.94842909
13cilium or flagellum-dependent cell motility (GO:0001539)3.67504774
14synaptonemal complex assembly (GO:0007130)3.66513220
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.64732488
16gene silencing (GO:0016458)3.59067559
17heterochromatin organization (GO:0070828)3.58029013
18histone H3-K9 methylation (GO:0051567)3.52697739
19male meiosis (GO:0007140)3.50749628
20histone lysine demethylation (GO:0070076)3.49622586
21histone H3-K4 trimethylation (GO:0080182)3.49172535
22histone H3-K4 methylation (GO:0051568)3.47534110
23monoubiquitinated protein deubiquitination (GO:0035520)3.47509057
24mitotic chromosome condensation (GO:0007076)3.46032775
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44099698
26mitotic nuclear envelope disassembly (GO:0007077)3.43972040
27sister chromatid segregation (GO:0000819)3.38939325
28synaptonemal complex organization (GO:0070193)3.37333873
29protein localization to chromosome, centromeric region (GO:0071459)3.37270279
30peptidyl-lysine dimethylation (GO:0018027)3.34598979
31protein-DNA complex disassembly (GO:0032986)3.31622040
32nucleosome disassembly (GO:0006337)3.31622040
33stress granule assembly (GO:0034063)3.31228147
34histone demethylation (GO:0016577)3.29311304
35RNA stabilization (GO:0043489)3.28800591
36mRNA stabilization (GO:0048255)3.28800591
37nuclear envelope disassembly (GO:0051081)3.25189542
38membrane disassembly (GO:0030397)3.25189542
39translesion synthesis (GO:0019985)3.25075252
40DNA unwinding involved in DNA replication (GO:0006268)3.21090481
41regulation of nucleobase-containing compound transport (GO:0032239)3.20484569
42protein localization to kinetochore (GO:0034501)3.20184236
43histone H3-K9 modification (GO:0061647)3.18132094
44dosage compensation (GO:0007549)3.17627530
45adherens junction assembly (GO:0034333)3.16554487
46positive regulation of histone deacetylation (GO:0031065)3.11821000
47DNA alkylation (GO:0006305)3.10353007
48DNA methylation (GO:0006306)3.10353007
49sister chromatid cohesion (GO:0007062)3.09956293
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.09603762
51positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.09603762
52positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.09603762
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.09395373
54regulation of sister chromatid cohesion (GO:0007063)3.09198204
55chromatin assembly (GO:0031497)3.09187696
56mitotic sister chromatid segregation (GO:0000070)3.09062172
57negative regulation of erythrocyte differentiation (GO:0045647)3.07134546
58histone lysine methylation (GO:0034968)3.06958486
59peptidyl-lysine trimethylation (GO:0018023)3.06874533
60embryonic camera-type eye morphogenesis (GO:0048596)3.06500540
61positive regulation of gamma-delta T cell activation (GO:0046645)3.06374865
62glucocorticoid receptor signaling pathway (GO:0042921)3.06287411
63DNA duplex unwinding (GO:0032508)3.05534772
64regulation of centriole replication (GO:0046599)3.05430448
65NLS-bearing protein import into nucleus (GO:0006607)3.03660761
66DNA geometric change (GO:0032392)3.03580510
67positive regulation of gene expression, epigenetic (GO:0045815)3.03309012
68focal adhesion assembly (GO:0048041)2.99057430
69cell-substrate adherens junction assembly (GO:0007045)2.99057430
70neural tube development (GO:0021915)2.97621661
71DNA packaging (GO:0006323)2.97075252
72chromosome condensation (GO:0030261)2.96026219
73positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.93892996
74regulation of DNA endoreduplication (GO:0032875)2.91977285
75regulation of chromatin binding (GO:0035561)2.90999544
76histone H3-K36 demethylation (GO:0070544)2.90653837
77DNA methylation involved in gamete generation (GO:0043046)2.90613832
78positive regulation of chromosome segregation (GO:0051984)2.87413826
79cytoskeletal anchoring at plasma membrane (GO:0007016)2.87050859
80protein dealkylation (GO:0008214)2.86889120
81protein demethylation (GO:0006482)2.86889120
82regulation of histone methylation (GO:0031060)2.86585035
83camera-type eye morphogenesis (GO:0048593)2.85537369
84chromatin silencing (GO:0006342)2.85536334
85DNA conformation change (GO:0071103)2.84572068
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82909976
87chromosome organization involved in meiosis (GO:0070192)2.82243483
88regulation of meiosis I (GO:0060631)2.80144518
89negative regulation of gene expression, epigenetic (GO:0045814)2.79913322
90regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79665145
91DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.79190136
92embryonic eye morphogenesis (GO:0048048)2.78496515
93histone deubiquitination (GO:0016578)2.77904590
94meiotic chromosome segregation (GO:0045132)2.77642797
95semaphorin-plexin signaling pathway (GO:0071526)2.76386507
96establishment of spindle orientation (GO:0051294)2.74782631
97meiotic nuclear division (GO:0007126)2.74469408
98regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.74179288
99positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.74179288
100regulation of gamma-delta T cell differentiation (GO:0045586)2.73940158
101protein localization to chromosome (GO:0034502)2.73765696
102eye morphogenesis (GO:0048592)2.73723242
103cellular response to epidermal growth factor stimulus (GO:0071364)2.73614259
104positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.72662733
105regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.72662733
106positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72060546
107peptidyl-lysine methylation (GO:0018022)2.71397324
108corticosteroid receptor signaling pathway (GO:0031958)2.70905612
109histone H4-K12 acetylation (GO:0043983)2.70831406
110response to epidermal growth factor (GO:0070849)2.70798597
111regulation of DNA damage checkpoint (GO:2000001)2.70464681
112regulation of NFAT protein import into nucleus (GO:0051532)2.69441221
113negative regulation of histone modification (GO:0031057)2.69420524
114histone H4-K16 acetylation (GO:0043984)2.69213974
115intracellular estrogen receptor signaling pathway (GO:0030520)2.68786092
116establishment of spindle localization (GO:0051293)2.68246954
117embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68068238
118negative regulation of DNA repair (GO:0045738)2.68028480
119regulation of mitotic spindle organization (GO:0060236)2.67865562
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67361001
121histone mRNA catabolic process (GO:0071044)2.67307304
122histone methylation (GO:0016571)2.66105363
123convergent extension (GO:0060026)2.64981020
124histone H3-K9 demethylation (GO:0033169)2.64815591
125regulation of histone H3-K4 methylation (GO:0051569)2.64811904
126nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.64744137
127nuclear envelope organization (GO:0006998)2.64596108
128alternative mRNA splicing, via spliceosome (GO:0000380)2.64146227
129negative regulation of mRNA metabolic process (GO:1903312)2.63627055
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63380254
131positive thymic T cell selection (GO:0045059)2.62333124
132DNA topological change (GO:0006265)2.59753575
133mannose metabolic process (GO:0006013)2.59542180
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.59044346
135paraxial mesoderm development (GO:0048339)2.57651294
136peptidyl-threonine phosphorylation (GO:0018107)2.57209977
137positive regulation by host of viral transcription (GO:0043923)2.53430208
138N-terminal protein amino acid acetylation (GO:0006474)2.52084534
139DNA synthesis involved in DNA repair (GO:0000731)2.51788812
1403-UTR-mediated mRNA stabilization (GO:0070935)2.51633836
141apoptotic process involved in morphogenesis (GO:0060561)2.49690873
142establishment of mitotic spindle localization (GO:0040001)2.49310706
143cell-substrate junction assembly (GO:0007044)2.45455616
144negative regulation of myotube differentiation (GO:0010832)2.45252188
145protein export from nucleus (GO:0006611)2.45050634
146peptidyl-threonine modification (GO:0018210)2.44355223
147coronary vasculature morphogenesis (GO:0060977)2.43827108
148heart morphogenesis (GO:0003007)2.43406477
149establishment of mitotic spindle orientation (GO:0000132)2.40617114
150establishment of nucleus localization (GO:0040023)2.40425682
151Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.39080464
152regulation of ARF GTPase activity (GO:0032312)2.38955857
153embryonic process involved in female pregnancy (GO:0060136)2.38820914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.92025870
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.84270250
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.14887351
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.82545722
5MYC_22102868_ChIP-Seq_BL_Human3.78948681
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25868873
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90628482
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70589402
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61046969
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.56755542
11TCF7_22412390_ChIP-Seq_EML_Mouse2.56666740
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43106078
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39214807
14VDR_21846776_ChIP-Seq_THP-1_Human2.34575563
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.29654053
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26001826
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.18163833
18* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.17122975
19* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.17116141
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.10063329
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05692310
22CIITA_25753668_ChIP-Seq_RAJI_Human2.04774592
23ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04187928
24KDM2B_26808549_Chip-Seq_DND41_Human1.97720816
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97243740
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93354424
27UTX_26944678_Chip-Seq_JUKART_Human1.91438256
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89860932
29LXR_22292898_ChIP-Seq_THP-1_Human1.81797398
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.80413192
31SCL_19346495_ChIP-Seq_HPC-7_Human1.78362112
32MAF_26560356_Chip-Seq_TH1_Human1.78283694
33MYB_26560356_Chip-Seq_TH1_Human1.73268267
34MYB_26560356_Chip-Seq_TH2_Human1.71698853
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70395432
36RACK7_27058665_Chip-Seq_MCF-7_Human1.68744617
37* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67083026
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61303010
39AR_21909140_ChIP-Seq_LNCAP_Human1.59282093
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58060918
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56588359
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55029580
43RUNX1_27514584_Chip-Seq_MCF-7_Human1.52659029
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49824628
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47429267
46PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46383537
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42527038
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41963122
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41963122
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41963122
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39948848
52CREB1_26743006_Chip-Seq_LNCaP_Human1.39414552
53* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.37657647
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.34440197
55KDM2B_26808549_Chip-Seq_JURKAT_Human1.34083114
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32702390
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32522955
58KDM5A_27292631_Chip-Seq_BREAST_Human1.29360841
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29240962
60* VDR_24763502_ChIP-Seq_THP-1_Human1.28648242
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26734866
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26295080
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26270179
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25566887
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.25040705
66SMC4_20622854_ChIP-Seq_HELA_Human1.24651688
67DROSHA_22980978_ChIP-Seq_HELA_Human1.24177331
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23973291
69ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23148945
70NCOR1_26117541_ChIP-Seq_K562_Human1.21976766
71CLOCK_20551151_ChIP-Seq_293T_Human1.21815582
72RUNX_20019798_ChIP-Seq_JUKART_Human1.21627988
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21340632
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20890229
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20770713
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.19907856
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19391452
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.17969293
79HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17482363
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16439008
81MAF_26560356_Chip-Seq_TH2_Human1.16107188
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.14771356
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13324185
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12669947
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11554543
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11549132
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11516415
88* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11193321
89SPI1_23127762_ChIP-Seq_K562_Human1.09241654
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08768470
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06179527
92EZH2_22144423_ChIP-Seq_EOC_Human1.05803358
93* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05615761
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04352319
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.03996682
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02982906
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02744549
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01687895
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00294237
100GATA1_26923725_Chip-Seq_HPCs_Mouse1.00064163
101UBF1/2_26484160_Chip-Seq_HMECs_Human0.99984674
102TP53_22127205_ChIP-Seq_IMR90_Human0.99257524
103CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99093870
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98903933
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98449482
106RARB_27405468_Chip-Seq_BRAIN_Mouse0.98045789
107NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96163481
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93177401
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.92987797
110MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92026063
111P68_20966046_ChIP-Seq_HELA_Human0.91823008
112ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91623639
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.91565214
114CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91524724
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91398455
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90014794
117* GATA3_27048872_Chip-Seq_THYMUS_Human0.89241171
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89016534
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88780560
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.88548135
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88254590
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.88250736
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87973786
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.87277407
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85608506
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85596016
127CHD1_26751641_Chip-Seq_LNCaP_Human0.85315667
128MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84979676
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84584774
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84522403
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83574735
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.81682132
133FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80872909
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.80540557
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80486085
136* SPI1_23547873_ChIP-Seq_NB4_Human0.79520254
137NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79149428
138ETS1_22383799_ChIP-Seq_G1ME_Mouse0.78237841
139* KDM2B_26808549_Chip-Seq_K562_Human0.76711827
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76410980
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.76159497
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.76066296
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75725033
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75016591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.03353146
2MP0000569_abnormal_digit_pigmentation3.47890695
3MP0010094_abnormal_chromosome_stability3.02443471
4MP0005409_darkened_coat_color3.00150698
5MP0008057_abnormal_DNA_replication2.98317910
6MP0003111_abnormal_nucleus_morphology2.93633674
7MP0005076_abnormal_cell_differentiation2.92694957
8MP0010352_gastrointestinal_tract_polyps2.62517089
9MP0003077_abnormal_cell_cycle2.51671564
10MP0002396_abnormal_hematopoietic_system2.51400561
11MP0005410_abnormal_fertilization2.42025969
12MP0002009_preneoplasia2.33105644
13MP0010307_abnormal_tumor_latency2.30660120
14MP0002249_abnormal_larynx_morphology2.28785947
15* MP0004808_abnormal_hematopoietic_stem2.20819835
16MP0003787_abnormal_imprinting2.07292274
17MP0000566_synostosis1.96976950
18MP0002653_abnormal_ependyma_morphology1.90908026
19MP0003693_abnormal_embryo_hatching1.90113001
20MP0010030_abnormal_orbit_morphology1.85811983
21MP0001929_abnormal_gametogenesis1.84775270
22MP0003300_gastrointestinal_ulcer1.84689460
23MP0003763_abnormal_thymus_physiology1.83254309
24MP0004957_abnormal_blastocyst_morpholog1.79641042
25MP0008058_abnormal_DNA_repair1.78676875
26MP0000350_abnormal_cell_proliferation1.76519307
27MP0008007_abnormal_cellular_replicative1.75091566
28MP0004185_abnormal_adipocyte_glucose1.73590443
29* MP0001730_embryonic_growth_arrest1.72850993
30MP0004233_abnormal_muscle_weight1.72846328
31* MP0009278_abnormal_bone_marrow1.72786879
32MP0003121_genomic_imprinting1.69982596
33MP0000703_abnormal_thymus_morphology1.68670443
34MP0002210_abnormal_sex_determination1.66645310
35MP0001348_abnormal_lacrimal_gland1.63828629
36MP0000537_abnormal_urethra_morphology1.61901946
37MP0004197_abnormal_fetal_growth/weight/1.59044806
38MP0008961_abnormal_basal_metabolism1.56514669
39MP0005380_embryogenesis_phenotype1.55851856
40MP0001672_abnormal_embryogenesis/_devel1.55851856
41MP0003698_abnormal_male_reproductive1.55460910
42* MP0002398_abnormal_bone_marrow1.53765062
43MP0003984_embryonic_growth_retardation1.53480883
44MP0002084_abnormal_developmental_patter1.52640822
45MP0002088_abnormal_embryonic_growth/wei1.50650156
46MP0003303_peritoneal_inflammation1.49385894
47MP0002089_abnormal_postnatal_growth/wei1.46343841
48MP0003705_abnormal_hypodermis_morpholog1.45734754
49* MP0001545_abnormal_hematopoietic_system1.44277709
50* MP0005397_hematopoietic_system_phenotyp1.44277709
51MP0002086_abnormal_extraembryonic_tissu1.42952356
52MP0002166_altered_tumor_susceptibility1.42233213
53MP0004858_abnormal_nervous_system1.42097684
54MP0001145_abnormal_male_reproductive1.38701974
55MP0000678_abnormal_parathyroid_gland1.37469655
56* MP0002085_abnormal_embryonic_tissue1.36527305
57MP0001697_abnormal_embryo_size1.36380767
58MP0003942_abnormal_urinary_system1.35945643
59MP0000733_abnormal_muscle_development1.30012553
60MP0001800_abnormal_humoral_immune1.27605332
61MP0002116_abnormal_craniofacial_bone1.25774208
62MP0000685_abnormal_immune_system1.25463941
63MP0003890_abnormal_embryonic-extraembry1.24208930
64* MP0003861_abnormal_nervous_system1.23172079
65MP0001873_stomach_inflammation1.22474106
66MP0008995_early_reproductive_senescence1.22052100
67MP0003385_abnormal_body_wall1.21020832
68MP0001849_ear_inflammation1.20534155
69MP0010630_abnormal_cardiac_muscle1.20459679
70MP0000653_abnormal_sex_gland1.20242144
71MP0003453_abnormal_keratinocyte_physiol1.19193005
72MP0000490_abnormal_crypts_of1.18343835
73MP0001915_intracranial_hemorrhage1.17642343
74MP0002722_abnormal_immune_system1.16965711
75* MP0002080_prenatal_lethality1.15932996
76MP0002019_abnormal_tumor_incidence1.14328157
77MP0005666_abnormal_adipose_tissue1.14021619
78MP0002006_tumorigenesis1.13352087
79MP0000313_abnormal_cell_death1.12854989
80MP0003283_abnormal_digestive_organ1.12049538
81MP0003115_abnormal_respiratory_system1.11717593
82MP0003045_fibrosis1.11231213
83MP0003123_paternal_imprinting1.11105495
84MP0000689_abnormal_spleen_morphology1.10200061
85MP0000716_abnormal_immune_system1.06893250
86MP0002114_abnormal_axial_skeleton1.03405407
87MP0001299_abnormal_eye_distance/1.02106748
88MP0002796_impaired_skin_barrier1.01325722
89MP0009703_decreased_birth_body1.00145526
90MP0005174_abnormal_tail_pigmentation0.99649663
91MP0002925_abnormal_cardiovascular_devel0.98862041
92MP0000534_abnormal_ureter_morphology0.98397516
93MP0002161_abnormal_fertility/fecundity0.97946190
94MP0001293_anophthalmia0.97308327
95* MP0002429_abnormal_blood_cell0.96942467
96MP0002405_respiratory_system_inflammati0.96666627
97MP0002877_abnormal_melanocyte_morpholog0.95365843
98MP0004264_abnormal_extraembryonic_tissu0.95286206
99MP0000579_abnormal_nail_morphology0.95275066
100MP0002420_abnormal_adaptive_immunity0.95129807
101MP0009053_abnormal_anal_canal0.94674949
102MP0002081_perinatal_lethality0.94531951
103MP0001819_abnormal_immune_cell0.93556662
104MP0003935_abnormal_craniofacial_develop0.93313482
105MP0005451_abnormal_body_composition0.93193220
106MP0002452_abnormal_antigen_presenting0.93100628
107MP0001835_abnormal_antigen_presentation0.92624059
108MP0002092_abnormal_eye_morphology0.91360731
109MP0001790_abnormal_immune_system0.91120039
110MP0005387_immune_system_phenotype0.91120039
111MP0003937_abnormal_limbs/digits/tail_de0.90929053
112MP0009672_abnormal_birth_weight0.89631183
113MP0003755_abnormal_palate_morphology0.88225543
114MP0001346_abnormal_lacrimal_gland0.87450153
115MP0003786_premature_aging0.86828811
116MP0005257_abnormal_intraocular_pressure0.86655247
117MP0000428_abnormal_craniofacial_morphol0.86118224
118MP0005375_adipose_tissue_phenotype0.85155489
119MP0002723_abnormal_immune_serum0.84347634
120MP0003943_abnormal_hepatobiliary_system0.83386245
121MP0000383_abnormal_hair_follicle0.83259699
122MP0004381_abnormal_hair_follicle0.82810037
123MP0003566_abnormal_cell_adhesion0.82183345
124MP0005671_abnormal_response_to0.82168765
125MP0005621_abnormal_cell_physiology0.81525026
126MP0005623_abnormal_meninges_morphology0.81137791
127MP0004947_skin_inflammation0.81118778
128MP0005384_cellular_phenotype0.80725953
129MP0003866_abnormal_defecation0.79682027
130MP0000462_abnormal_digestive_system0.79383121
131MP0000266_abnormal_heart_morphology0.79129708
132MP0008932_abnormal_embryonic_tissue0.78913647
133MP0003091_abnormal_cell_migration0.77881447
134MP0002108_abnormal_muscle_morphology0.77735533
135MP0000432_abnormal_head_morphology0.77326723
136MP0001286_abnormal_eye_development0.76530978
137MP0002060_abnormal_skin_morphology0.76368180
138MP0010368_abnormal_lymphatic_system0.76086725
139MP0002928_abnormal_bile_duct0.75654371
140MP0006138_congestive_heart_failure0.75357209
141MP0004087_abnormal_muscle_fiber0.74117696
142MP0001784_abnormal_fluid_regulation0.73830544
143MP0002697_abnormal_eye_size0.73599350
144MP0002932_abnormal_joint_morphology0.73562412
145MP0006292_abnormal_olfactory_placode0.73136889
146MP0010155_abnormal_intestine_physiology0.72536258
147MP0000759_abnormal_skeletal_muscle0.71374625
148MP0002970_abnormal_white_adipose0.71133540
149MP0001340_abnormal_eyelid_morphology0.70862011
150MP0009931_abnormal_skin_appearance0.70840402

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.37478218
2Obstructive sleep apnea (HP:0002870)4.08619257
3Volvulus (HP:0002580)3.41102999
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.21242563
5Short 4th metacarpal (HP:0010044)3.21242563
6Heterotopia (HP:0002282)3.08266316
7Broad face (HP:0000283)3.07591133
8Hyperacusis (HP:0010780)3.05414451
9Long eyelashes (HP:0000527)2.92983536
10Increased nuchal translucency (HP:0010880)2.81575986
11Nasal polyposis (HP:0100582)2.73792041
12Shallow orbits (HP:0000586)2.71631444
13Prominent nose (HP:0000448)2.69690029
14Flat acetabular roof (HP:0003180)2.63340494
15Ectopic kidney (HP:0000086)2.62056041
16Trigonocephaly (HP:0000243)2.59753645
17Vertebral arch anomaly (HP:0008438)2.51679315
18Disproportionate tall stature (HP:0001519)2.51298238
19Macroorchidism (HP:0000053)2.49147517
20Renovascular hypertension (HP:0100817)2.47597897
21High pitched voice (HP:0001620)2.43396881
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.42733582
23Abnormality of the aortic arch (HP:0012303)2.40187214
24Ependymoma (HP:0002888)2.38263539
25Dysmetric saccades (HP:0000641)2.37867152
26Abnormality of the phalanges of the hallux (HP:0010057)2.31580347
27Ulnar bowing (HP:0003031)2.31296806
28Abnormality of the astrocytes (HP:0100707)2.29321726
29Astrocytoma (HP:0009592)2.29321726
30Truncal obesity (HP:0001956)2.27853396
31Absent frontal sinuses (HP:0002688)2.27758543
32Elfin facies (HP:0004428)2.27548776
33Abnormality of the 4th metacarpal (HP:0010012)2.25528829
34High anterior hairline (HP:0009890)2.24906400
35Broad palm (HP:0001169)2.23356775
36Urethral obstruction (HP:0000796)2.21898095
37Chromsome breakage (HP:0040012)2.18692896
38Obsessive-compulsive behavior (HP:0000722)2.17962550
39Abnormality of the nasal mucosa (HP:0000433)2.17638164
40Recurrent bronchitis (HP:0002837)2.17088514
41Proximal placement of thumb (HP:0009623)2.16557779
42Acute myeloid leukemia (HP:0004808)2.15093335
43Neoplasm of the oral cavity (HP:0100649)2.14577405
44Medulloblastoma (HP:0002885)2.13929289
45Narrow palate (HP:0000189)2.12933413
46Deviation of the thumb (HP:0009603)2.11674657
47Renal duplication (HP:0000075)2.10540616
48Cerebral aneurysm (HP:0004944)2.09731367
49Long palpebral fissure (HP:0000637)2.08838226
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.06761164
51Absent/shortened dynein arms (HP:0200106)2.06761164
52Abnormality of the lower motor neuron (HP:0002366)2.06709251
53Mitral valve prolapse (HP:0001634)2.06434937
54Pointed chin (HP:0000307)2.05695434
55Impulsivity (HP:0100710)2.04920387
56Abnormality of the columella (HP:0009929)2.04485857
57Sandal gap (HP:0001852)2.03729914
58Anal stenosis (HP:0002025)2.01673574
59Ankyloglossia (HP:0010296)2.00155442
60Overriding aorta (HP:0002623)1.99239080
61Persistence of primary teeth (HP:0006335)1.98406391
62Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94741666
63Bronchomalacia (HP:0002780)1.94053322
64Patellar dislocation (HP:0002999)1.93856259
65Broad finger (HP:0001500)1.92974651
66Limited elbow extension (HP:0001377)1.92640210
67Arnold-Chiari malformation (HP:0002308)1.90958424
68Selective tooth agenesis (HP:0001592)1.90755733
69Glioma (HP:0009733)1.90274470
70Sparse lateral eyebrow (HP:0005338)1.89610611
71Recurrent viral infections (HP:0004429)1.89265860
72Deep palmar crease (HP:0006191)1.89070090
73Supernumerary ribs (HP:0005815)1.88449349
74Cutis marmorata (HP:0000965)1.87751644
75Basal cell carcinoma (HP:0002671)1.86827966
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86431315
77T lymphocytopenia (HP:0005403)1.86050992
78Turricephaly (HP:0000262)1.85685415
79Abnormality of the carotid arteries (HP:0005344)1.84984276
80Bowel diverticulosis (HP:0005222)1.84814887
81Thin ribs (HP:0000883)1.84792997
82Bowel incontinence (HP:0002607)1.83346457
83Increased density of long bones (HP:0006392)1.83173788
84Abnormality of the distal phalanx of the thumb (HP:0009617)1.82523349
85Deep philtrum (HP:0002002)1.81762998
86Low anterior hairline (HP:0000294)1.81427438
87Advanced eruption of teeth (HP:0006288)1.81333516
88Skull defect (HP:0001362)1.80332761
89Asymmetry of the thorax (HP:0001555)1.80273858
90Protrusio acetabuli (HP:0003179)1.79961931
91Short phalanx of the thumb (HP:0009660)1.78995360
92Genetic anticipation (HP:0003743)1.78800622
93Recurrent otitis media (HP:0000403)1.78785526
94Precocious puberty (HP:0000826)1.78620886
95Spinal cord lesions (HP:0100561)1.78196505
96Syringomyelia (HP:0003396)1.78196505
97Abnormality of the parietal bone (HP:0002696)1.78109831
98Abnormality of chromosome stability (HP:0003220)1.77964918
99Bronchitis (HP:0012387)1.76142180
100Cafe-au-lait spot (HP:0000957)1.75262217
101Dislocated radial head (HP:0003083)1.75138500
102Broad distal phalanx of finger (HP:0009836)1.74555610
103Spina bifida occulta (HP:0003298)1.74458514
104Abnormality of the thoracic spine (HP:0100711)1.73755903
105Germ cell neoplasia (HP:0100728)1.72719595
106Broad thumb (HP:0011304)1.72086937
107Neoplasm of striated muscle (HP:0009728)1.71294151
108Acute lymphatic leukemia (HP:0006721)1.69896599
109Papillary thyroid carcinoma (HP:0002895)1.69864011
110Abnormality of the humeroradial joint (HP:0100744)1.69404901
111Distal upper limb amyotrophy (HP:0007149)1.68078393
112Upper limb amyotrophy (HP:0009129)1.68078393
113Natal tooth (HP:0000695)1.68036295
114Abnormality of the radial head (HP:0003995)1.68031258
115Flat cornea (HP:0007720)1.68007955
116Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.67467418
117Mitral regurgitation (HP:0001653)1.66985463
118Skin tags (HP:0010609)1.66529690
119Myelodysplasia (HP:0002863)1.65839914
120Laryngomalacia (HP:0001601)1.65611262
121Broad phalanx (HP:0006009)1.65569871
122Abnormal vertebral ossification (HP:0100569)1.65185581
123Abnormality of the intervertebral disk (HP:0005108)1.64848059
124Abnormality of oral frenula (HP:0000190)1.63925411
125Abnormality of T cell number (HP:0011839)1.63600005
126Abnormality of the epiphyses of the hand (HP:0005924)1.63206260
127Malignant gastrointestinal tract tumors (HP:0006749)1.61865230
128Gastrointestinal carcinoma (HP:0002672)1.61865230
129Megalocornea (HP:0000485)1.61701110
130Abnormal large intestine physiology (HP:0012700)1.61503743
131Insomnia (HP:0100785)1.61417642
132Abnormal number of incisors (HP:0011064)1.60667735
133Hypoplasia of the maxilla (HP:0000327)1.60628070
134Broad long bones (HP:0005622)1.60454706
135Facial hemangioma (HP:0000329)1.60107006
136Joint laxity (HP:0001388)1.59867223
137Lip pit (HP:0100267)1.59460035
138Thick eyebrow (HP:0000574)1.58608603
139Abnormality of the calcaneus (HP:0008364)1.57625189
140Broad metatarsal (HP:0001783)1.57441866
141Self-mutilation (HP:0000742)1.55840817
142Annular pancreas (HP:0001734)1.54807356
143Depressed nasal tip (HP:0000437)1.54746416
144Bronchiectasis (HP:0002110)1.54661811
145Supernumerary bones of the axial skeleton (HP:0009144)1.54567126
146Amyotrophic lateral sclerosis (HP:0007354)1.54060845
147Tracheomalacia (HP:0002779)1.53190045
148Attention deficit hyperactivity disorder (HP:0007018)1.53145164
149Smooth philtrum (HP:0000319)1.53108221
150Abnormality of incisor morphology (HP:0011063)1.52750106
151Gastrointestinal inflammation (HP:0004386)1.51525070
152Sacral dimple (HP:0000960)1.50252415
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.50036059
154Aortic aneurysm (HP:0004942)1.49907642
155Hypoplastic labia majora (HP:0000059)1.49803283
156Broad phalanges of the hand (HP:0009768)1.49484551
157Overlapping toe (HP:0001845)1.48703313
158Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.48570182
159Bicuspid aortic valve (HP:0001647)1.48313783
160Abnormality of chromosome segregation (HP:0002916)1.48173057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.71188784
2EEF2K3.70538243
3SMG13.40502929
4MAP3K103.29338659
5CDC73.14784526
6ICK3.00424365
7NEK22.86682334
8BRD42.77918391
9CAMK1G2.48781717
10PRPF4B2.45883840
11CAMK1D2.38793594
12MAP4K12.10675970
13SIK21.69899182
14TRIB31.64977920
15LATS11.63003529
16STK101.61657740
17MTOR1.60717134
18ATR1.60234808
19STK31.57753428
20PKN21.54354045
21CDK91.49143004
22CDK41.43314156
23TTK1.40191682
24PRKD31.37789233
25PASK1.31024067
26CHEK11.28734424
27CDK61.22769857
28MAP3K131.19734540
29FGFR31.17730719
30PTK61.13705664
31TYRO31.10617851
32JAK31.09030995
33ATM1.08350591
34PNCK1.01069134
35STK41.00111193
36CDK70.98545852
37CHEK20.98308177
38RPS6KB20.97680829
39SIK10.95432657
40LATS20.94987968
41ALK0.93993703
42ERN10.93959546
43MAP3K90.92650045
44RIPK10.90528912
45PDK30.88284530
46PDK40.88284530
47FGFR40.86427540
48MELK0.86123016
49CDK20.85755909
50CHUK0.84119991
51PIM10.81616476
52RPS6KA40.80334586
53TYK20.78798948
54FGFR20.76525590
55PDGFRB0.75074262
56KSR20.74033716
57PDGFRA0.73820780
58MAP3K80.72920225
59BTK0.70940916
60WEE10.70774383
61PLK10.70359545
62RPS6KA20.69947188
63NLK0.69002089
64TTN0.68560245
65AURKB0.68342923
66GRK60.67941084
67MAP3K70.67852157
68JAK10.67222512
69CSF1R0.65757937
70MAPK100.65237408
71BRSK10.64537095
72RPS6KC10.64321677
73RPS6KL10.64321677
74MARK20.64172956
75BRSK20.64091704
76TESK10.63384545
77TAOK10.63066943
78SGK20.62906148
79* CDK10.61636762
80ITK0.61601746
81WNK10.61418936
82TAOK30.61006751
83SGK30.60918107
84ZAP700.60866006
85PTK20.60385661
86MAPK110.59558173
87HCK0.59185728
88CAMKK10.58978789
89CLK10.57785316
90TXK0.57301625
91DYRK1B0.55115538
92MAP3K40.55102374
93CDK30.55067286
94AKT30.55050327
95CAMK40.54917656
96EPHB10.54375167
97PAK20.54069944
98DYRK30.53919532
99* MAPK140.52755946
100CSK0.51611277
101HIPK20.50346822
102STK380.49789029
103PRKCH0.49707833
104PRKDC0.48849510
105PRKD20.48756896
106CSNK1D0.48081883
107GSK3B0.47668520
108FGFR10.47660528
109MET0.47500761
110MKNK20.47282925
111NEK90.47195682
112RPS6KA60.47167476
113TGFBR10.46030820
114MAPK10.45137489
115LRRK20.44940149
116MARK30.44866102
117SGK4940.44491725
118SGK2230.44491725
119RET0.44241291
120DMPK0.44161614
121MAPK80.43683213
122AKT10.43489523
123CDC42BPA0.42837717
124BMX0.41062538
125PAK40.40527476
126RPS6KA10.39899389
127PRKAA10.39658645
128MKNK10.39465869
129PLK40.39458821
130LCK0.38822596
131MAP2K30.38407592
132MAPK150.37990560
133NTRK10.37189950

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.06310130
2Lysine degradation_Homo sapiens_hsa003101.99653488
3mRNA surveillance pathway_Homo sapiens_hsa030151.99173529
4DNA replication_Homo sapiens_hsa030301.95665756
5RNA transport_Homo sapiens_hsa030131.79031875
6Fanconi anemia pathway_Homo sapiens_hsa034601.77519534
7Primary immunodeficiency_Homo sapiens_hsa053401.69226305
8Dorso-ventral axis formation_Homo sapiens_hsa043201.68803211
9Chronic myeloid leukemia_Homo sapiens_hsa052201.67586444
10B cell receptor signaling pathway_Homo sapiens_hsa046621.66536893
11Mismatch repair_Homo sapiens_hsa034301.63438388
12Notch signaling pathway_Homo sapiens_hsa043301.55416691
13Spliceosome_Homo sapiens_hsa030401.53660493
14Base excision repair_Homo sapiens_hsa034101.52902679
15MicroRNAs in cancer_Homo sapiens_hsa052061.46816837
16Herpes simplex infection_Homo sapiens_hsa051681.45902846
17T cell receptor signaling pathway_Homo sapiens_hsa046601.45877252
18Non-homologous end-joining_Homo sapiens_hsa034501.45689872
19Antigen processing and presentation_Homo sapiens_hsa046121.39749860
20Homologous recombination_Homo sapiens_hsa034401.35643912
21HTLV-I infection_Homo sapiens_hsa051661.35277243
22Acute myeloid leukemia_Homo sapiens_hsa052211.33507960
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32242554
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.30096965
25Viral carcinogenesis_Homo sapiens_hsa052031.29864438
26Colorectal cancer_Homo sapiens_hsa052101.28862031
27Small cell lung cancer_Homo sapiens_hsa052221.28304109
28mTOR signaling pathway_Homo sapiens_hsa041501.27224692
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26661930
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25790476
31Pancreatic cancer_Homo sapiens_hsa052121.23303807
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22196804
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21781809
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20362636
35Phospholipase D signaling pathway_Homo sapiens_hsa040721.17723191
36Basal transcription factors_Homo sapiens_hsa030221.16185748
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15657401
38RNA degradation_Homo sapiens_hsa030181.13851281
39Measles_Homo sapiens_hsa051621.12905347
40Insulin signaling pathway_Homo sapiens_hsa049101.12613716
41Non-small cell lung cancer_Homo sapiens_hsa052231.12336616
42p53 signaling pathway_Homo sapiens_hsa041151.12180361
43Hepatitis B_Homo sapiens_hsa051611.11423819
44Long-term potentiation_Homo sapiens_hsa047201.10690635
45Viral myocarditis_Homo sapiens_hsa054161.10318381
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09413115
47Osteoclast differentiation_Homo sapiens_hsa043801.08653204
48Bladder cancer_Homo sapiens_hsa052191.08337044
49Melanogenesis_Homo sapiens_hsa049161.04567099
50Adherens junction_Homo sapiens_hsa045201.03305641
51Endometrial cancer_Homo sapiens_hsa052131.02466397
52Toxoplasmosis_Homo sapiens_hsa051451.02332368
53GnRH signaling pathway_Homo sapiens_hsa049120.98366035
54Influenza A_Homo sapiens_hsa051640.97957137
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97247440
56Prostate cancer_Homo sapiens_hsa052150.96733343
57Basal cell carcinoma_Homo sapiens_hsa052170.96178909
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.95405050
59Epstein-Barr virus infection_Homo sapiens_hsa051690.95227376
60Oocyte meiosis_Homo sapiens_hsa041140.94381464
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94105845
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.90551986
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88438737
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87808426
65One carbon pool by folate_Homo sapiens_hsa006700.87048052
66Systemic lupus erythematosus_Homo sapiens_hsa053220.86173719
67Apoptosis_Homo sapiens_hsa042100.86023621
68Nucleotide excision repair_Homo sapiens_hsa034200.85726154
69Prolactin signaling pathway_Homo sapiens_hsa049170.85429934
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83866699
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83506828
72Axon guidance_Homo sapiens_hsa043600.82397393
73FoxO signaling pathway_Homo sapiens_hsa040680.82008414
74TNF signaling pathway_Homo sapiens_hsa046680.81723643
75Proteoglycans in cancer_Homo sapiens_hsa052050.80709264
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80583925
77Hematopoietic cell lineage_Homo sapiens_hsa046400.79903999
78Leishmaniasis_Homo sapiens_hsa051400.79521598
79VEGF signaling pathway_Homo sapiens_hsa043700.79441766
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79240238
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79012689
82Type II diabetes mellitus_Homo sapiens_hsa049300.78330033
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78178861
84Glioma_Homo sapiens_hsa052140.77190417
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76939009
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76275109
87Rap1 signaling pathway_Homo sapiens_hsa040150.75993949
88Insulin resistance_Homo sapiens_hsa049310.75175923
89Gap junction_Homo sapiens_hsa045400.75157523
90Pathways in cancer_Homo sapiens_hsa052000.74502415
91HIF-1 signaling pathway_Homo sapiens_hsa040660.74046781
92Inositol phosphate metabolism_Homo sapiens_hsa005620.71493570
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70822849
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.70325940
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.69857034
96Wnt signaling pathway_Homo sapiens_hsa043100.69557230
97ECM-receptor interaction_Homo sapiens_hsa045120.68878237
98Melanoma_Homo sapiens_hsa052180.68778488
99Estrogen signaling pathway_Homo sapiens_hsa049150.68381500
100Prion diseases_Homo sapiens_hsa050200.68188606
101Platelet activation_Homo sapiens_hsa046110.67135876
102Chemokine signaling pathway_Homo sapiens_hsa040620.66733293
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66562994
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66178677
105Amoebiasis_Homo sapiens_hsa051460.66046719
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65962950
107Renal cell carcinoma_Homo sapiens_hsa052110.65119646
108Hedgehog signaling pathway_Homo sapiens_hsa043400.64435891
109Glucagon signaling pathway_Homo sapiens_hsa049220.63805785
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63424536
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.63152140
112MAPK signaling pathway_Homo sapiens_hsa040100.62859044
113TGF-beta signaling pathway_Homo sapiens_hsa043500.62771729
114Tight junction_Homo sapiens_hsa045300.62392058
115ErbB signaling pathway_Homo sapiens_hsa040120.61828256
116Hepatitis C_Homo sapiens_hsa051600.61642876
117Focal adhesion_Homo sapiens_hsa045100.59803724
118Hippo signaling pathway_Homo sapiens_hsa043900.59327562
119Cholinergic synapse_Homo sapiens_hsa047250.59249649
120Shigellosis_Homo sapiens_hsa051310.58909115
121Choline metabolism in cancer_Homo sapiens_hsa052310.58750224
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.57943530
123AMPK signaling pathway_Homo sapiens_hsa041520.57832261
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57571827
125Thyroid cancer_Homo sapiens_hsa052160.57461040
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57341536
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55979232
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55961777
129Thyroid hormone synthesis_Homo sapiens_hsa049180.54737892
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51720323
131Ras signaling pathway_Homo sapiens_hsa040140.51523518
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50831344
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50437322
134Long-term depression_Homo sapiens_hsa047300.49609777

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