EPAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* surfactant homeostasis (GO:0043129)5.20152467
2vascular endothelial growth factor signaling pathway (GO:0038084)4.60351408
3lymph vessel development (GO:0001945)4.35260364
4regulation of endothelial cell differentiation (GO:0045601)4.33227800
5lymphangiogenesis (GO:0001946)4.14076860
6retina vasculature morphogenesis in camera-type eye (GO:0061299)4.11137757
7* chemical homeostasis within a tissue (GO:0048875)4.07835442
8blood vessel maturation (GO:0001955)3.91026525
9epoxygenase P450 pathway (GO:0019373)3.82572874
10regulation of vasculogenesis (GO:2001212)3.70864518
11cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.63832529
12positive regulation of endothelial cell differentiation (GO:0045603)3.51949189
13endothelial tube morphogenesis (GO:0061154)3.39990466
14morphogenesis of an endothelium (GO:0003159)3.39990466
15endothelium development (GO:0003158)3.34572415
16positive regulation of vasculogenesis (GO:2001214)3.30203963
17apoptotic cell clearance (GO:0043277)3.28719317
18peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.27627352
19ethanol oxidation (GO:0006069)3.23441775
20endothelial cell morphogenesis (GO:0001886)3.22761233
21cell migration involved in heart development (GO:0060973)3.22652293
22hormone catabolic process (GO:0042447)3.21210707
23renal filtration (GO:0097205)3.18354314
24fatty acid transmembrane transport (GO:1902001)3.13864089
25endothelial cell differentiation (GO:0045446)3.13085464
26extracellular matrix assembly (GO:0085029)3.12039353
27protein heterotrimerization (GO:0070208)3.11362732
28glomerular filtration (GO:0003094)3.07373968
29cell-substrate junction assembly (GO:0007044)3.03949982
30negative regulation of complement activation (GO:0045916)3.02737063
31cell migration involved in sprouting angiogenesis (GO:0002042)3.01711688
32xenobiotic catabolic process (GO:0042178)3.01010294
33cell adhesion mediated by integrin (GO:0033627)3.00553344
34alpha-linolenic acid metabolic process (GO:0036109)2.99525656
35basement membrane organization (GO:0071711)2.99016952
36positive regulation of endothelial cell apoptotic process (GO:2000353)2.98275159
37regulation of integrin-mediated signaling pathway (GO:2001044)2.92606341
38regulation of p38MAPK cascade (GO:1900744)2.89951745
39bundle of His cell to Purkinje myocyte communication (GO:0086069)2.89882813
40barbed-end actin filament capping (GO:0051016)2.87749867
41blood vessel endothelial cell migration (GO:0043534)2.86614158
42negative regulation of protein activation cascade (GO:2000258)2.85002673
43virion attachment to host cell (GO:0019062)2.84205143
44adhesion of symbiont to host cell (GO:0044650)2.84205143
45endodermal cell differentiation (GO:0035987)2.83367760
46extracellular fibril organization (GO:0043206)2.82054112
47toxin metabolic process (GO:0009404)2.81554071
48heart trabecula formation (GO:0060347)2.80409855
49positive regulation of p38MAPK cascade (GO:1900745)2.80069120
50skin morphogenesis (GO:0043589)2.79459661
51hemidesmosome assembly (GO:0031581)2.79356712
52venous blood vessel morphogenesis (GO:0048845)2.77647865
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.76496416
54patterning of blood vessels (GO:0001569)2.75256716
55negative regulation of fibrinolysis (GO:0051918)2.75099740
56positive regulation of extracellular matrix organization (GO:1903055)2.74363197
57endocrine hormone secretion (GO:0060986)2.74064867
58lung vasculature development (GO:0060426)2.73049925
59positive regulation of receptor recycling (GO:0001921)2.73030346
60vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.72729419
61regulation of complement activation (GO:0030449)2.72371538
62low-density lipoprotein particle clearance (GO:0034383)2.72127755
63regulation of protein activation cascade (GO:2000257)2.71996399
64carnitine shuttle (GO:0006853)2.71840529
65adhesion of symbiont to host (GO:0044406)2.68332310
66transcytosis (GO:0045056)2.67763083
67complement activation, alternative pathway (GO:0006957)2.67575890
68coronary vasculature morphogenesis (GO:0060977)2.65873681
69keratan sulfate catabolic process (GO:0042340)2.65846689
70adherens junction assembly (GO:0034333)2.64190190
71negative regulation of fatty acid transport (GO:2000192)2.61062970
72wound healing, spreading of epidermal cells (GO:0035313)2.60746357
73flavonoid metabolic process (GO:0009812)2.60576277
74regulation of sequestering of triglyceride (GO:0010889)2.60459354
75endothelial cell chemotaxis (GO:0035767)2.60329745
76fibril organization (GO:0097435)2.58365679
77atrioventricular valve morphogenesis (GO:0003181)2.56744204
78lung lobe morphogenesis (GO:0060463)2.56083243
79fatty acid beta-oxidation (GO:0006635)2.55343215
80cell-substrate adherens junction assembly (GO:0007045)2.55196561
81focal adhesion assembly (GO:0048041)2.55196561
82protein localization to endosome (GO:0036010)2.54725532
83regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.54333450
84positive regulation of fatty acid beta-oxidation (GO:0032000)2.54041595
85type B pancreatic cell proliferation (GO:0044342)2.53783595
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.53538574
87cell volume homeostasis (GO:0006884)2.51955162
88endocardial cushion development (GO:0003197)2.51770784
89negative regulation of smooth muscle cell migration (GO:0014912)2.51221056
90response to mercury ion (GO:0046689)2.50981124
91phenylpropanoid metabolic process (GO:0009698)2.49377375
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48896494
93lysine catabolic process (GO:0006554)2.48604486
94lysine metabolic process (GO:0006553)2.48604486
95ovulation from ovarian follicle (GO:0001542)2.48236648
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.48226436
97negative regulation of humoral immune response (GO:0002921)2.47454657
98positive regulation of fatty acid oxidation (GO:0046321)2.44712464
99glomerular visceral epithelial cell development (GO:0072015)2.44528638
100fatty acid oxidation (GO:0019395)2.44521861
101desmosome organization (GO:0002934)2.43890640
102drug metabolic process (GO:0017144)2.43365137
103negative regulation of Rho protein signal transduction (GO:0035024)2.43272028
104omega-hydroxylase P450 pathway (GO:0097267)2.43049575
105glomerular epithelial cell development (GO:0072310)2.42499002
106collagen fibril organization (GO:0030199)2.40284229
107negative regulation of blood vessel endothelial cell migration (GO:0043537)2.40172710
108phospholipid homeostasis (GO:0055091)2.39906739
109lipid oxidation (GO:0034440)2.39898914
110regulation of fibrinolysis (GO:0051917)2.39458639
111regulation of apoptotic cell clearance (GO:2000425)2.38896847
112vasculogenesis (GO:0001570)2.38460183
113cell proliferation involved in metanephros development (GO:0072203)2.37112054
114regulation of cholesterol storage (GO:0010885)2.36371714
115ethanol metabolic process (GO:0006067)2.35011035
116artery development (GO:0060840)2.34174667
117regulation of cholesterol homeostasis (GO:2000188)2.33436359
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.32114303
119regulation of extracellular matrix disassembly (GO:0010715)2.32057932
120regulation of cardioblast differentiation (GO:0051890)2.31894193
121peptidyl-glutamic acid carboxylation (GO:0017187)2.31325935
122protein carboxylation (GO:0018214)2.31325935
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31153436
124regulation of triglyceride catabolic process (GO:0010896)2.30928191
125sulfur amino acid catabolic process (GO:0000098)2.30538124
126gap junction assembly (GO:0016264)2.28600340
127sodium-independent organic anion transport (GO:0043252)2.28056021
128triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.27552453
129regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.27464051
130collagen metabolic process (GO:0032963)2.26633604
131negative regulation of platelet activation (GO:0010544)2.26432224
132response to xenobiotic stimulus (GO:0009410)2.26370877
133extracellular matrix disassembly (GO:0022617)2.26220817
134glomerular basement membrane development (GO:0032836)2.26077547
135regulation of skeletal muscle contraction (GO:0014819)2.26048346
136positive regulation of blood vessel endothelial cell migration (GO:0043536)2.25645916
137stress fiber assembly (GO:0043149)2.25627140
138regulation of glomerular filtration (GO:0003093)2.25333424
139regulation of fatty acid oxidation (GO:0046320)2.23641336
140hyaluronan catabolic process (GO:0030214)2.23117794
141negative regulation of endothelial cell migration (GO:0010596)2.23026221
142regulation of axon extension involved in axon guidance (GO:0048841)2.22485623
143cAMP biosynthetic process (GO:0006171)2.22185390
144positive regulation of osteoblast proliferation (GO:0033690)2.21726225
145regulation of plasminogen activation (GO:0010755)2.21671839
146L-phenylalanine catabolic process (GO:0006559)2.21592755
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.21592755
148L-phenylalanine metabolic process (GO:0006558)2.21543187
149erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.21543187
150regulation of endothelial cell apoptotic process (GO:2000351)2.20995582
151renal absorption (GO:0070293)2.20764803
152sequestering of extracellular ligand from receptor (GO:0035581)2.20187781
153epithelial cell-cell adhesion (GO:0090136)2.20073777
154smooth muscle tissue development (GO:0048745)2.19795712
155multicellular organismal macromolecule metabolic process (GO:0044259)2.18777384
156chondrocyte proliferation (GO:0035988)2.15917384
157substrate-dependent cell migration (GO:0006929)2.14787664
158sprouting angiogenesis (GO:0002040)2.12692823
159extracellular matrix organization (GO:0030198)2.12320938
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.12041878
161extracellular structure organization (GO:0043062)2.11381830
162multicellular organismal metabolic process (GO:0044236)2.11373108
163regulation of membrane protein ectodomain proteolysis (GO:0051043)2.10433850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64425690
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.95809736
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.01979317
4CLOCK_20551151_ChIP-Seq_293T_Human2.86772200
5* LXR_22158963_ChIP-Seq_LIVER_Mouse2.85002644
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.62232457
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44640521
8* TRIM28_21343339_ChIP-Seq_HEK293_Human2.30330780
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28807418
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.27841359
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.27450296
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.24856828
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.09107046
14ESR1_21235772_ChIP-Seq_MCF-7_Human1.95787194
15EP300_21415370_ChIP-Seq_HL-1_Mouse1.92764980
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90788508
17GATA1_22025678_ChIP-Seq_K562_Human1.83089957
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.82734828
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.79587600
20ZNF263_19887448_ChIP-Seq_K562_Human1.73293291
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70460021
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.64072165
23TBX20_22328084_ChIP-Seq_HEART_Mouse1.64072165
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60715037
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.54651714
26* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53463412
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46743055
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44984003
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40149091
30* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40004917
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39154947
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38015948
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38008379
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36741011
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.36624251
36AHR_22903824_ChIP-Seq_MCF-7_Human1.36336936
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.35490004
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32128839
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28928877
40* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27666159
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27553187
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.26617602
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26429644
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25110218
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25110218
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23701469
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23701469
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23508594
49CDX2_20551321_ChIP-Seq_CACO-2_Human1.22435138
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21142281
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.20809504
52P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19993970
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17860238
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16805656
55SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15603090
56SMC1_22415368_ChIP-Seq_MEFs_Mouse1.15033776
57* GATA1_19941826_ChIP-Seq_K562_Human1.14604031
58* CJUN_26792858_Chip-Seq_BT549_Human1.14548293
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13474513
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12592153
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12464425
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12407154
63* KDM2B_26808549_Chip-Seq_K562_Human1.11780308
64* SOX2_20726797_ChIP-Seq_SW620_Human1.09792698
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09549197
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08264938
67RACK7_27058665_Chip-Seq_MCF-7_Human1.06241811
68* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04616745
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.04442166
70FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04420759
71DROSHA_22980978_ChIP-Seq_HELA_Human1.03686980
72* BRD4_25478319_ChIP-Seq_HGPS_Human1.03195550
73* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02983260
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02438100
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.02316098
76* EED_16625203_ChIP-ChIP_MESCs_Mouse1.01996075
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01683783
78UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00885359
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00736562
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00691983
81CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99198924
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98726042
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98726042
84SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98464226
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98423369
86* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98086449
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98081044
88* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98038096
89* ARNT_22903824_ChIP-Seq_MCF-7_Human0.97560544
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96691942
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95998763
92* UBF1/2_26484160_Chip-Seq_HMECs_Human0.95981508
93* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95807909
94* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95133108
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92230658
96RUNX1_27514584_Chip-Seq_MCF-7_Human0.91782631
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91708539
98* LXR_22292898_ChIP-Seq_THP-1_Human0.91309844
99BCAT_22108803_ChIP-Seq_LS180_Human0.90817003
100* TP53_23651856_ChIP-Seq_MEFs_Mouse0.89636797
101* TP53_18474530_ChIP-ChIP_U2OS_Human0.89573466
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89062128
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88882412
104WT1_19549856_ChIP-ChIP_CCG9911_Human0.88446331
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87871217
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85190923
107ISL1_27105846_Chip-Seq_CPCs_Mouse0.85103996
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.85093401
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85060087
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.84000531
111NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83978149
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82101294
113* GATA2_19941826_ChIP-Seq_K562_Human0.82080690
114* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81925807
115* GATA4_25053715_ChIP-Seq_YYC3_Human0.81809959
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81397942
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.81259693
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80331074
119* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79360144
120* TCF4_18268006_ChIP-ChIP_LS174T_Human0.77734307
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76447026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.32040016
2MP0005167_abnormal_blood-brain_barrier4.15743154
3MP0001879_abnormal_lymphatic_vessel3.96290203
4MP0008875_abnormal_xenobiotic_pharmacok3.46051454
5MP0004272_abnormal_basement_membrane3.28608569
6MP0005503_abnormal_tendon_morphology3.08633578
7MP0002139_abnormal_hepatobiliary_system2.95876621
8MP0004084_abnormal_cardiac_muscle2.84753268
9MP0001958_emphysema2.67364854
10MP0002138_abnormal_hepatobiliary_system2.66467289
11MP0005360_urolithiasis2.53181327
12MP0005085_abnormal_gallbladder_physiolo2.46718041
13MP0005365_abnormal_bile_salt2.39475463
14MP0004782_abnormal_surfactant_physiolog2.31158846
15MP0003724_increased_susceptibility_to2.29646628
16MP0003828_pulmonary_edema2.21570903
17MP0003191_abnormal_cellular_cholesterol2.14956311
18MP0004130_abnormal_muscle_cell2.14827763
19MP0010329_abnormal_lipoprotein_level2.00993888
20MP0005670_abnormal_white_adipose2.00147296
21MP0004036_abnormal_muscle_relaxation1.97344710
22MP0005023_abnormal_wound_healing1.94650801
23MP0002837_dystrophic_cardiac_calcinosis1.87417624
24MP0003705_abnormal_hypodermis_morpholog1.85136971
25MP0005257_abnormal_intraocular_pressure1.80616423
26MP0003279_aneurysm1.72109939
27MP0005409_darkened_coat_color1.71955941
28* MP0006138_congestive_heart_failure1.70132765
29MP0004215_abnormal_myocardial_fiber1.63078991
30MP0001542_abnormal_bone_strength1.62073293
31MP0003566_abnormal_cell_adhesion1.61072407
32MP0000767_abnormal_smooth_muscle1.60737267
33MP0006054_spinal_hemorrhage1.59378042
34MP0000751_myopathy1.57906438
35MP0005165_increased_susceptibility_to1.55684968
36* MP0001544_abnormal_cardiovascular_syste1.55262360
37* MP0005385_cardiovascular_system_phenoty1.55262360
38MP0003252_abnormal_bile_duct1.54963070
39MP0005330_cardiomyopathy1.54770015
40MP0002295_abnormal_pulmonary_circulatio1.54130583
41MP0004484_altered_response_of1.50333465
42MP0000343_altered_response_to1.48925745
43MP0008775_abnormal_heart_ventricle1.48340030
44MP0005595_abnormal_vascular_smooth1.47317337
45MP0002108_abnormal_muscle_morphology1.44397064
46MP0005083_abnormal_biliary_tract1.43274254
47MP0002060_abnormal_skin_morphology1.38209155
48MP0009840_abnormal_foam_cell1.37862884
49MP0005666_abnormal_adipose_tissue1.37198612
50MP0002972_abnormal_cardiac_muscle1.33467564
51MP0002332_abnormal_exercise_endurance1.31787290
52MP0004883_abnormal_blood_vessel1.31372830
53MP0004185_abnormal_adipocyte_glucose1.30161853
54MP0005332_abnormal_amino_acid1.29967395
55MP0010630_abnormal_cardiac_muscle1.29686169
56MP0002118_abnormal_lipid_homeostasis1.29306720
57* MP0000249_abnormal_blood_vessel1.29104847
58MP0002877_abnormal_melanocyte_morpholog1.28424540
59MP0002896_abnormal_bone_mineralization1.27638883
60MP0010352_gastrointestinal_tract_polyps1.25378166
61MP0005508_abnormal_skeleton_morphology1.23271227
62MP0005388_respiratory_system_phenotype1.21839174
63MP0002133_abnormal_respiratory_system1.21839174
64MP0003941_abnormal_skin_development1.20923902
65MP0005058_abnormal_lysosome_morphology1.19700058
66MP0002127_abnormal_cardiovascular_syste1.15574908
67MP0005620_abnormal_muscle_contractility1.14997912
68MP0000230_abnormal_systemic_arterial1.14319035
69MP0004087_abnormal_muscle_fiber1.12561996
70MP0002933_joint_inflammation1.11630371
71MP0008004_abnormal_stomach_pH1.11251414
72* MP0002128_abnormal_blood_circulation1.09536192
73MP0003300_gastrointestinal_ulcer1.08987126
74MP0002998_abnormal_bone_remodeling1.08709312
75* MP0004085_abnormal_heartbeat1.08447798
76MP0005319_abnormal_enzyme/_coenzyme1.07744004
77MP0009643_abnormal_urine_homeostasis1.07323712
78MP0003075_altered_response_to1.06490155
79MP0008438_abnormal_cutaneous_collagen1.06195472
80MP0005623_abnormal_meninges_morphology1.05381369
81MP0008995_early_reproductive_senescence1.04637567
82MP0005375_adipose_tissue_phenotype1.03466713
83MP0003690_abnormal_glial_cell1.02456704
84* MP0005164_abnormal_response_to1.02315166
85MP0004858_abnormal_nervous_system1.02267616
86MP0000013_abnormal_adipose_tissue1.01880342
87MP0001849_ear_inflammation0.99067509
88MP0001756_abnormal_urination0.98140610
89MP0003303_peritoneal_inflammation0.97749138
90MP0000609_abnormal_liver_physiology0.96937131
91MP0003868_abnormal_feces_composition0.95408349
92MP0009764_decreased_sensitivity_to0.95240428
93MP0003453_abnormal_keratinocyte_physiol0.93863436
94MP0004019_abnormal_vitamin_homeostasis0.93638193
95MP0003329_amyloid_beta_deposits0.92845813
96MP0002971_abnormal_brown_adipose0.91034619
97MP0003950_abnormal_plasma_membrane0.89563191
98* MP0001614_abnormal_blood_vessel0.88599380
99MP0000749_muscle_degeneration0.88320970
100MP0009780_abnormal_chondrocyte_physiolo0.87001241
101* MP0002925_abnormal_cardiovascular_devel0.85990959
102MP0002254_reproductive_system_inflammat0.85153815
103MP0003091_abnormal_cell_migration0.84957878
104MP0000759_abnormal_skeletal_muscle0.84557787
105MP0003646_muscle_fatigue0.84198571
106MP0001915_intracranial_hemorrhage0.82796242
107MP0008961_abnormal_basal_metabolism0.82644804
108MP0009384_cardiac_valve_regurgitation0.81866011
109MP0003806_abnormal_nucleotide_metabolis0.79589758
110MP0002796_impaired_skin_barrier0.78971629
111MP0001851_eye_inflammation0.78929542
112MP0003045_fibrosis0.77921848
113MP0005166_decreased_susceptibility_to0.77683199
114MP0009115_abnormal_fat_cell0.77406022
115MP0005076_abnormal_cell_differentiation0.77163073
116MP0000534_abnormal_ureter_morphology0.76974885
117MP0005390_skeleton_phenotype0.76397074
118MP0000762_abnormal_tongue_morphology0.75966590
119MP0001177_atelectasis0.75918359
120MP0002909_abnormal_adrenal_gland0.75419587
121MP0001661_extended_life_span0.75102022
122MP0000003_abnormal_adipose_tissue0.74931872
123MP0005584_abnormal_enzyme/coenzyme_acti0.74694049
124MP0005275_abnormal_skin_tensile0.74651829
125MP0000733_abnormal_muscle_development0.74403928
126MP0001666_abnormal_nutrient_absorption0.72703750
127MP0000750_abnormal_muscle_regeneration0.72146639
128* MP0000266_abnormal_heart_morphology0.70664824
129MP0000604_amyloidosis0.70124380
130MP0000467_abnormal_esophagus_morphology0.67302400
131MP0004510_myositis0.66389241
132MP0001243_abnormal_dermal_layer0.66170452
133MP0001175_abnormal_lung_morphology0.65487236
134MP0001533_abnormal_skeleton_physiology0.65365895
135MP0002168_other_aberrant_phenotype0.65250447
136MP0003448_altered_tumor_morphology0.64942201
137MP0002136_abnormal_kidney_physiology0.64294374
138MP0010234_abnormal_vibrissa_follicle0.62890512
139MP0005647_abnormal_sex_gland0.62761553

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.93507250
2Premature rupture of membranes (HP:0001788)4.74764956
3Deep venous thrombosis (HP:0002625)4.74639454
4* Polycythemia (HP:0001901)4.63438655
5Esophageal varix (HP:0002040)4.45697424
6Vascular tortuosity (HP:0004948)4.41370617
7Hematochezia (HP:0002573)4.25543395
8Arterial tortuosity (HP:0005116)4.07892289
9Spontaneous hematomas (HP:0007420)4.05796584
10Hyperactive renin-angiotensin system (HP:0000841)3.88092974
11Aortic dissection (HP:0002647)3.87940475
12Right ventricular cardiomyopathy (HP:0011663)3.59510211
13Broad metatarsal (HP:0001783)3.46328091
14Visceral angiomatosis (HP:0100761)3.32437236
15Cerebral hemorrhage (HP:0001342)3.29464013
16Spinal rigidity (HP:0003306)3.24367813
17Complement deficiency (HP:0004431)3.18606769
18Cervical subluxation (HP:0003308)3.18489257
19Interstitial pulmonary disease (HP:0006530)3.18060945
20Type 1 muscle fiber predominance (HP:0003803)3.17340698
21Sudden death (HP:0001699)3.14313095
22Ankle contracture (HP:0006466)3.13146173
23Muscle fiber splitting (HP:0003555)3.12197404
24Wormian bones (HP:0002645)3.06858471
25Hyporeflexia of lower limbs (HP:0002600)3.06266176
26Hemangiomatosis (HP:0007461)3.05812271
27Systemic lupus erythematosus (HP:0002725)3.02492538
28Vertebral compression fractures (HP:0002953)3.01551948
29Ventricular tachycardia (HP:0004756)2.98142182
30Hypoglycemic coma (HP:0001325)2.96955849
31Cerebral aneurysm (HP:0004944)2.93961370
32Abnormality of the nasal mucosa (HP:0000433)2.88581673
33Hyperlipoproteinemia (HP:0010980)2.86289949
34Hyperkalemia (HP:0002153)2.86181749
35Atrophic scars (HP:0001075)2.86016205
36Xanthomatosis (HP:0000991)2.83422002
37Shallow orbits (HP:0000586)2.81927090
38Bladder diverticulum (HP:0000015)2.72340709
39Conjunctival telangiectasia (HP:0000524)2.70361522
40Lymphangioma (HP:0100764)2.70092681
41Hypoalphalipoproteinemia (HP:0003233)2.69950668
42Increased connective tissue (HP:0009025)2.69611188
43Growth hormone excess (HP:0000845)2.69453766
44Hyperglycinuria (HP:0003108)2.69192103
45Mildly elevated creatine phosphokinase (HP:0008180)2.68087625
46Potter facies (HP:0002009)2.67232528
47Facial shape deformation (HP:0011334)2.67232528
48Pulmonary artery stenosis (HP:0004415)2.62776647
49Dilatation of the ascending aorta (HP:0005111)2.61122303
50Abnormality of skeletal muscle fiber size (HP:0012084)2.60863780
51Distal lower limb muscle weakness (HP:0009053)2.60835424
52Renal salt wasting (HP:0000127)2.60583639
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.60068201
54Osteolytic defects of the hand bones (HP:0009699)2.60068201
55Intrahepatic cholestasis (HP:0001406)2.59377961
56Gout (HP:0001997)2.58932372
57Soft skin (HP:0000977)2.56033109
58Follicular hyperkeratosis (HP:0007502)2.53168304
59Fragile skin (HP:0001030)2.51353229
60Mitral valve prolapse (HP:0001634)2.50194663
61Difficulty running (HP:0009046)2.48851191
62Hemorrhage of the eye (HP:0011885)2.47749411
63Atrial fibrillation (HP:0005110)2.45073200
64Atrioventricular block (HP:0001678)2.39943317
65Syncope (HP:0001279)2.39556440
66Mitral stenosis (HP:0001718)2.35500712
67Blue sclerae (HP:0000592)2.33599344
68Hyperammonemia (HP:0001987)2.33403819
69Abnormality of monocarboxylic acid metabolism (HP:0010996)2.32519492
70Exercise-induced myalgia (HP:0003738)2.31158610
71Stroke (HP:0001297)2.29779822
72Ketoacidosis (HP:0001993)2.29691781
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28560808
74Cavernous hemangioma (HP:0001048)2.28276909
75Ketosis (HP:0001946)2.26579691
76Adactyly (HP:0009776)2.26435697
77Aneurysm (HP:0002617)2.25048539
78Bronchomalacia (HP:0002780)2.24993309
79Primary atrial arrhythmia (HP:0001692)2.24788598
80Supraventricular arrhythmia (HP:0005115)2.24147680
81Myoglobinuria (HP:0002913)2.23604449
82Abnormality of glycine metabolism (HP:0010895)2.23360809
83Abnormality of serine family amino acid metabolism (HP:0010894)2.23360809
84Overgrowth (HP:0001548)2.21893691
85Hyperaldosteronism (HP:0000859)2.20867086
86Joint hemorrhage (HP:0005261)2.20643071
87Glomerulonephritis (HP:0000099)2.20055443
88Abnormality of fatty-acid metabolism (HP:0004359)2.17527879
89Mesangial abnormality (HP:0001966)2.16807660
90Neonatal short-limb short stature (HP:0008921)2.16548443
91Long toe (HP:0010511)2.15549761
92Wrist flexion contracture (HP:0001239)2.14992725
93Skin nodule (HP:0200036)2.13583314
94Striae distensae (HP:0001065)2.13200726
95Exercise-induced muscle cramps (HP:0003710)2.12875143
96Hypokalemic alkalosis (HP:0001949)2.11528351
97Acanthosis nigricans (HP:0000956)2.11526524
98Heart block (HP:0012722)2.10817944
99Portal hypertension (HP:0001409)2.10039357
100Joint laxity (HP:0001388)2.09786424
101Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09192606
102Vascular calcification (HP:0004934)2.08733659
103Bundle branch block (HP:0011710)2.08392854
104Supraventricular tachycardia (HP:0004755)2.07936158
105Cardiovascular calcification (HP:0011915)2.05099176
106Obstructive sleep apnea (HP:0002870)2.05050651
107Mucopolysacchariduria (HP:0008155)2.04879983
108Urinary glycosaminoglycan excretion (HP:0003541)2.04879983
109Abnormality of complement system (HP:0005339)2.04624245
110Abnormality of renin-angiotensin system (HP:0000847)2.04567108
111Respiratory distress (HP:0002098)2.03503134
112Pigmentary retinal degeneration (HP:0001146)2.03394972
113Abnormal atrioventricular conduction (HP:0005150)2.03208623
114Lipoatrophy (HP:0100578)2.03201610
115Tubulointerstitial fibrosis (HP:0005576)2.02592803
116Aortic aneurysm (HP:0004942)2.02357235
117Mitral regurgitation (HP:0001653)2.00343910
118Aortic valve stenosis (HP:0001650)1.99302964
119Nephritis (HP:0000123)1.99207685
120Neurofibrillary tangles (HP:0002185)1.98783778
121Distal lower limb amyotrophy (HP:0008944)1.98371305
122Tachypnea (HP:0002789)1.98281055
123Slender build (HP:0001533)1.96826451
124Abnormality of dentin (HP:0010299)1.96583432
125Camptodactyly of toe (HP:0001836)1.96397041
126Joint stiffness (HP:0001387)1.96054201
127Abnormality of the acetabulum (HP:0003170)1.94502284
128Aortic regurgitation (HP:0001659)1.94430854
129Short hallux (HP:0010109)1.93923500
130Pulmonary embolism (HP:0002204)1.93670745
131Myocardial infarction (HP:0001658)1.93338340
132Spondylolisthesis (HP:0003302)1.92523028
133Short nail (HP:0001799)1.92232213
134Chronic bronchitis (HP:0004469)1.91301799
135Pulmonary hypertension (HP:0002092)1.90171188
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90087273
137Abnormality of polysaccharide metabolism (HP:0011012)1.90087273
138Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90087273
139Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89829118
140Increased variability in muscle fiber diameter (HP:0003557)1.89785975
141Hypolipoproteinemia (HP:0010981)1.89735930
142Abnormality of the intrinsic pathway (HP:0010989)1.87832091
143Hyperextensible skin (HP:0000974)1.87436705
144Asymmetric septal hypertrophy (HP:0001670)1.86862712
145Abnormality of purine metabolism (HP:0004352)1.86792748
146Delayed CNS myelination (HP:0002188)1.86691486
147Neonatal death (HP:0003811)1.86285427
148Axonal loss (HP:0003447)1.85886119
149Abnormality of chloride homeostasis (HP:0011422)1.85346878
150Glomerulosclerosis (HP:0000096)1.84879248
151Focal segmental glomerulosclerosis (HP:0000097)1.84782038
152Disproportionate tall stature (HP:0001519)1.83423158
153Abnormality of the common coagulation pathway (HP:0010990)1.83160188
154Abnormality of the hepatic vasculature (HP:0006707)1.82537054
155Venous abnormality (HP:0002624)1.82499649
156Chondrocalcinosis (HP:0000934)1.81747228
157Nuclear cataract (HP:0100018)1.80084834
158Hypoplasia of the iris (HP:0007676)1.78760242
159Elbow flexion contracture (HP:0002987)1.75733337
160Coxa vara (HP:0002812)1.75126155
161Peritonitis (HP:0002586)1.73036246
162Wide anterior fontanel (HP:0000260)1.72822370
163Nonimmune hydrops fetalis (HP:0001790)1.71956627
164Ectopia lentis (HP:0001083)1.71125429
165Natal tooth (HP:0000695)1.69357525
166Dysostosis multiplex (HP:0000943)1.68001651
167Ovoid vertebral bodies (HP:0003300)1.67736081
168Advanced eruption of teeth (HP:0006288)1.66158075
169Glucose intolerance (HP:0000833)1.66045903
170Ulnar bowing (HP:0003031)1.64829978
171Upper limb amyotrophy (HP:0009129)1.64226695
172Distal upper limb amyotrophy (HP:0007149)1.64226695
173Cerebral inclusion bodies (HP:0100314)1.63696620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.03999261
2KDR3.69699244
3TGFBR23.53715368
4RIPK12.72511992
5TRIB32.53812040
6EPHB22.30617442
7LATS22.16988584
8ERN12.08709948
9MYLK2.05998900
10EPHB11.90864435
11FGFR41.87515875
12PDGFRA1.74505433
13TTN1.64237451
14TESK11.61148175
15FER1.57357540
16CDC42BPA1.57204786
17GRK11.55579931
18FGFR21.53045718
19TGFBR11.51262187
20DMPK1.50331945
21LMTK21.48625433
22BCKDK1.45498766
23SIK11.41785716
24MAP3K31.33102308
25TRPM71.32466573
26PDK21.31536605
27PTK2B1.29795153
28PTK61.24229977
29MAP3K61.24031918
30ICK1.22407721
31INSRR1.20513083
32PRPF4B1.19464423
33PAK21.18253420
34PHKG21.16205140
35PHKG11.16205140
36CAMK1D1.15917999
37MAP2K31.15053300
38MAPKAPK31.07813597
39EEF2K1.07453739
40PKN21.06070898
41WNK41.04600676
42CAMK1G1.00716590
43RPS6KA20.95893014
44MAPK150.95763371
45PAK40.95021965
46FGFR30.94853801
47DAPK20.94825458
48LATS10.92774619
49PDGFRB0.91721205
50PINK10.91005712
51ABL20.90656467
52PRKG20.88293511
53PRKD30.87890170
54AKT30.87459489
55MTOR0.86004197
56PRKCH0.85546373
57LRRK20.85520145
58MAP3K70.85301876
59GRK50.82989605
60PDK40.82914885
61PDK30.82914885
62PRKAA20.82454151
63MAPK120.81301595
64ERBB40.80666813
65EPHA30.80150336
66* PRKD10.78558302
67PAK30.78171204
68CDK120.77766476
69MAP3K130.77187989
70CSK0.76252203
71MAP3K20.75247799
72TYRO30.75219830
73MOS0.73496264
74ZAP700.73332240
75SGK30.71437222
76GSK3A0.71148583
77STK390.69832559
78EPHA20.69737803
79LIMK10.69235808
80PTK20.68740673
81ROCK20.68124756
82MAP3K10.64664498
83JAK10.63006464
84MAP2K20.62735062
85STK240.62636902
86MAP2K10.61758780
87SMG10.58935469
88NEK90.57302887
89MET0.57099353
90OBSCN0.56519179
91MST1R0.56415921
92RET0.56266193
93ARAF0.56150638
94IRAK30.55444856
95MAPK40.54872294
96CAMK2G0.54769532
97SGK2230.52181686
98SGK4940.52181686
99CAMK40.51472076
100TBK10.48670545
101ROCK10.47454535
102TYK20.47168674
103STK100.46118393
104MARK20.45950245
105MAPK70.45949212
106SGK20.45612145
107JAK20.45254054
108KIT0.44636973
109STK38L0.44032476
110DAPK30.43895110
111SRC0.42867353
112TAOK10.42298015
113FRK0.41741748
114MAP3K110.41294239
115STK380.41288828
116GRK70.40996759
117IGF1R0.40682584
118PRKD20.40062495
119CAMK10.40016886
120PIK3CA0.39937999
121RPS6KL10.39808947
122RPS6KC10.39808947
123NLK0.39613322
124EGFR0.39172518
125ILK0.38625247
126PRKAA10.37456901
127MAP2K40.37285435
128HIPK20.37147377
129ADRBK10.36275829
130CDK60.36075503
131* PDPK10.35434506
132PDK10.35292677
133DDR20.35146898
134WNK10.34767148
135MAPK110.34611253
136PRKCE0.34264687
137KSR20.33664905
138BMX0.33241295
139NTRK10.33135617

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.41852497
2Fatty acid degradation_Homo sapiens_hsa000712.54762644
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.22813722
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14930929
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.13743319
6PPAR signaling pathway_Homo sapiens_hsa033202.09880757
7Arginine biosynthesis_Homo sapiens_hsa002202.09646488
8Propanoate metabolism_Homo sapiens_hsa006402.06832795
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05105318
10Caffeine metabolism_Homo sapiens_hsa002322.01526699
11Complement and coagulation cascades_Homo sapiens_hsa046102.00981964
12Tryptophan metabolism_Homo sapiens_hsa003802.00321150
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.98884062
14Fatty acid metabolism_Homo sapiens_hsa012121.97811347
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89322456
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88037218
17Bile secretion_Homo sapiens_hsa049761.69904269
18Chemical carcinogenesis_Homo sapiens_hsa052041.67599403
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59725210
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58984129
21Other glycan degradation_Homo sapiens_hsa005111.57823258
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50118035
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44372858
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43675539
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42782461
26Fatty acid biosynthesis_Homo sapiens_hsa000611.36841812
27ECM-receptor interaction_Homo sapiens_hsa045121.36003636
28Butanoate metabolism_Homo sapiens_hsa006501.31474346
29beta-Alanine metabolism_Homo sapiens_hsa004101.31471263
30Retinol metabolism_Homo sapiens_hsa008301.30357784
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25018172
32Dilated cardiomyopathy_Homo sapiens_hsa054141.23989127
33Pertussis_Homo sapiens_hsa051331.23527400
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.21231570
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18052435
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14776300
37Focal adhesion_Homo sapiens_hsa045101.08995646
38Peroxisome_Homo sapiens_hsa041461.08091122
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07043995
40Staphylococcus aureus infection_Homo sapiens_hsa051501.05924486
41Adherens junction_Homo sapiens_hsa045201.05794057
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03988551
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03266897
44Malaria_Homo sapiens_hsa051441.03078099
45Histidine metabolism_Homo sapiens_hsa003401.02643461
46Lysosome_Homo sapiens_hsa041421.01162236
47Starch and sucrose metabolism_Homo sapiens_hsa005000.97118282
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96961972
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.95689711
50Glycerolipid metabolism_Homo sapiens_hsa005610.95351442
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92663804
52Phenylalanine metabolism_Homo sapiens_hsa003600.90313461
53Pyruvate metabolism_Homo sapiens_hsa006200.89931865
54ABC transporters_Homo sapiens_hsa020100.89128971
55Dorso-ventral axis formation_Homo sapiens_hsa043200.87647926
56Insulin resistance_Homo sapiens_hsa049310.87088345
57Bladder cancer_Homo sapiens_hsa052190.86588811
58Fatty acid elongation_Homo sapiens_hsa000620.85943952
59Renin secretion_Homo sapiens_hsa049240.84975297
60Amoebiasis_Homo sapiens_hsa051460.82689423
61GnRH signaling pathway_Homo sapiens_hsa049120.82595782
62Carbon metabolism_Homo sapiens_hsa012000.79039380
63Fat digestion and absorption_Homo sapiens_hsa049750.78890377
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74753982
65Tyrosine metabolism_Homo sapiens_hsa003500.73998202
66Ovarian steroidogenesis_Homo sapiens_hsa049130.73872260
67Renin-angiotensin system_Homo sapiens_hsa046140.73811590
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.71784360
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.70051955
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68356567
71Tight junction_Homo sapiens_hsa045300.67156495
72Chronic myeloid leukemia_Homo sapiens_hsa052200.67015216
73Sulfur metabolism_Homo sapiens_hsa009200.66826554
74Rap1 signaling pathway_Homo sapiens_hsa040150.65970917
75TGF-beta signaling pathway_Homo sapiens_hsa043500.65935738
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.65788183
77Lysine degradation_Homo sapiens_hsa003100.62529869
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62375608
79Estrogen signaling pathway_Homo sapiens_hsa049150.61514749
80Arginine and proline metabolism_Homo sapiens_hsa003300.60563507
81Endocytosis_Homo sapiens_hsa041440.59353988
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59310432
83Pancreatic cancer_Homo sapiens_hsa052120.58779613
84Phagosome_Homo sapiens_hsa041450.57449726
85Gastric acid secretion_Homo sapiens_hsa049710.57096856
86MicroRNAs in cancer_Homo sapiens_hsa052060.56699941
87* Pathways in cancer_Homo sapiens_hsa052000.56293721
88Vitamin digestion and absorption_Homo sapiens_hsa049770.55444445
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55194513
90* Renal cell carcinoma_Homo sapiens_hsa052110.54202544
91Glioma_Homo sapiens_hsa052140.54100504
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53877945
93Sphingolipid metabolism_Homo sapiens_hsa006000.53421065
94Toxoplasmosis_Homo sapiens_hsa051450.52198012
95Galactose metabolism_Homo sapiens_hsa000520.52073609
96Choline metabolism in cancer_Homo sapiens_hsa052310.51796898
97Pancreatic secretion_Homo sapiens_hsa049720.51361522
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51349313
99Glutathione metabolism_Homo sapiens_hsa004800.50931432
100TNF signaling pathway_Homo sapiens_hsa046680.50033212
101Prion diseases_Homo sapiens_hsa050200.49543051
102Melanogenesis_Homo sapiens_hsa049160.49403574
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49373731
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.48575846
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48430010
106Ras signaling pathway_Homo sapiens_hsa040140.47425191
107Salivary secretion_Homo sapiens_hsa049700.47135852
108Mineral absorption_Homo sapiens_hsa049780.46494127
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45421268
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45276264
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45097011
112Hippo signaling pathway_Homo sapiens_hsa043900.45020152
113Small cell lung cancer_Homo sapiens_hsa052220.44779049
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44719322
115AMPK signaling pathway_Homo sapiens_hsa041520.44614384
116Proteoglycans in cancer_Homo sapiens_hsa052050.43939456
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.43596968
118Protein digestion and absorption_Homo sapiens_hsa049740.43185594
119Platelet activation_Homo sapiens_hsa046110.42724493
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42365318
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41106049
122Glucagon signaling pathway_Homo sapiens_hsa049220.38634252
123Notch signaling pathway_Homo sapiens_hsa043300.38254829
124cAMP signaling pathway_Homo sapiens_hsa040240.37894257
125Axon guidance_Homo sapiens_hsa043600.35630678
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.35264081
127Thyroid hormone synthesis_Homo sapiens_hsa049180.34315385
128Insulin signaling pathway_Homo sapiens_hsa049100.33599807
129Sulfur relay system_Homo sapiens_hsa041220.32692710
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32373800
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32272564
132Selenocompound metabolism_Homo sapiens_hsa004500.32051582
133Circadian rhythm_Homo sapiens_hsa047100.31619583
134African trypanosomiasis_Homo sapiens_hsa051430.31463604
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31410032
136VEGF signaling pathway_Homo sapiens_hsa043700.30792289
137Gap junction_Homo sapiens_hsa045400.29638670
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29461933
139Cardiac muscle contraction_Homo sapiens_hsa042600.29183902

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