EPB41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)8.72716737
2protoporphyrinogen IX biosynthetic process (GO:0006782)7.73195315
3positive regulation of gamma-delta T cell activation (GO:0046645)7.07372451
4porphyrin-containing compound biosynthetic process (GO:0006779)5.88346730
5negative regulation of cell killing (GO:0031342)5.83264091
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.83264091
7regulation of B cell receptor signaling pathway (GO:0050855)5.71888421
8regulation of gamma-delta T cell differentiation (GO:0045586)5.30367573
9tetrapyrrole biosynthetic process (GO:0033014)5.19710313
10regulation of gamma-delta T cell activation (GO:0046643)5.04683092
11heme biosynthetic process (GO:0006783)5.02135650
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.95825723
13microglial cell activation (GO:0001774)4.88982896
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85099822
15negative T cell selection (GO:0043383)4.80986797
16hepatocyte apoptotic process (GO:0097284)4.79563443
17positive T cell selection (GO:0043368)4.78927491
18hemoglobin metabolic process (GO:0020027)4.78290334
19porphyrin-containing compound metabolic process (GO:0006778)4.70280180
20negative thymic T cell selection (GO:0045060)4.69174723
21positive thymic T cell selection (GO:0045059)4.63022231
22positive regulation of granulocyte differentiation (GO:0030854)4.57329085
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51474176
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.51474176
25modulation by symbiont of host immune response (GO:0052553)4.51474176
26positive regulation by symbiont of host defense response (GO:0052509)4.51474176
27modulation by symbiont of host defense response (GO:0052031)4.51474176
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51474176
29negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.50796729
30erythrocyte maturation (GO:0043249)4.34716363
31lysine catabolic process (GO:0006554)4.31964779
32lysine metabolic process (GO:0006553)4.31964779
33detection of molecule of bacterial origin (GO:0032490)4.28747126
34very-low-density lipoprotein particle assembly (GO:0034379)4.18642470
35B cell receptor signaling pathway (GO:0050853)4.12049935
36negative regulation of T cell mediated immunity (GO:0002710)4.07305280
37embryonic retina morphogenesis in camera-type eye (GO:0060059)4.05562726
38phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.04036307
39cysteine metabolic process (GO:0006534)3.97714652
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.97377692
41heme metabolic process (GO:0042168)3.92271370
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.92238212
43plasma lipoprotein particle assembly (GO:0034377)3.87906764
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.75503301
45T cell selection (GO:0045058)3.72057274
46cellular extravasation (GO:0045123)3.65262745
47regulation of cholesterol homeostasis (GO:2000188)3.64065897
48macrophage activation involved in immune response (GO:0002281)3.60971577
49neutrophil mediated immunity (GO:0002446)3.57623751
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57109696
51response to interleukin-15 (GO:0070672)3.56847127
52macrophage activation (GO:0042116)3.55719871
53protein-lipid complex assembly (GO:0065005)3.55505158
54positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.54205383
55regulation of necroptotic process (GO:0060544)3.53338333
56thymic T cell selection (GO:0045061)3.52537678
57regulation of rhodopsin mediated signaling pathway (GO:0022400)3.51308581
58positive regulation of B cell differentiation (GO:0045579)3.51009833
59negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.50885440
60regulation of B cell differentiation (GO:0045577)3.50455166
61rhodopsin mediated signaling pathway (GO:0016056)3.50026754
62retinal cone cell development (GO:0046549)3.48890952
63myeloid leukocyte mediated immunity (GO:0002444)3.43651050
64detection of external biotic stimulus (GO:0098581)3.39722509
65negative regulation of erythrocyte differentiation (GO:0045647)3.39058102
66histone H3-K4 trimethylation (GO:0080182)3.38321049
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.36847984
68activated T cell proliferation (GO:0050798)3.34526314
69alpha-linolenic acid metabolic process (GO:0036109)3.33947480
70pre-miRNA processing (GO:0031054)3.33666855
71histone mRNA catabolic process (GO:0071044)3.33400737
72antigen processing and presentation of endogenous antigen (GO:0019883)3.32159085
73kynurenine metabolic process (GO:0070189)3.31888433
74sulfur amino acid catabolic process (GO:0000098)3.30607108
75glyoxylate metabolic process (GO:0046487)3.30253755
76detection of other organism (GO:0098543)3.26805509
77negative regulation of fatty acid biosynthetic process (GO:0045717)3.26615427
78photoreceptor cell development (GO:0042461)3.24947342
79dosage compensation (GO:0007549)3.21887497
80oxygen transport (GO:0015671)3.21883231
81regulation of fatty acid beta-oxidation (GO:0031998)3.20620565
82T cell migration (GO:0072678)3.20275278
83regulation of beta-amyloid formation (GO:1902003)3.18049146
84nuclear pore complex assembly (GO:0051292)3.17319663
85L-phenylalanine catabolic process (GO:0006559)3.17183111
86erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17183111
87L-phenylalanine metabolic process (GO:0006558)3.16493708
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.16493708
89response to methylmercury (GO:0051597)3.14258569
90erythrocyte development (GO:0048821)3.14241394
91regulation of RNA export from nucleus (GO:0046831)3.12750023
92serine family amino acid catabolic process (GO:0009071)3.12638100
93myeloid cell development (GO:0061515)3.12618955
94negative regulation of B cell proliferation (GO:0030889)3.12022798
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11232582
96response to host immune response (GO:0052572)3.11232582
97urea metabolic process (GO:0019627)3.10640543
98urea cycle (GO:0000050)3.10640543
99regulation of granulocyte differentiation (GO:0030852)3.09391746
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09369560
101negative regulation of leukocyte mediated immunity (GO:0002704)3.09003290
102monoubiquitinated protein deubiquitination (GO:0035520)3.07560719
103negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06713970
1042-oxoglutarate metabolic process (GO:0006103)3.05317708
105leukocyte aggregation (GO:0070486)3.05032967
106positive regulation of cellular response to oxidative stress (GO:1900409)3.04413254
107positive regulation of response to oxidative stress (GO:1902884)3.04413254
108retinal rod cell development (GO:0046548)3.04210558
109eye photoreceptor cell development (GO:0042462)3.02447713
110protein K11-linked deubiquitination (GO:0035871)3.01527571
111neutrophil activation involved in immune response (GO:0002283)3.00928799
112megakaryocyte development (GO:0035855)3.00849912
113dicarboxylic acid biosynthetic process (GO:0043650)3.00006890
114aromatic amino acid family catabolic process (GO:0009074)2.97761501
115erythrocyte differentiation (GO:0030218)2.96996321
116positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.95672516
117mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.95672516
118positive regulation of histone deacetylation (GO:0031065)2.94325468
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93950843
120negative regulation of interleukin-12 production (GO:0032695)2.93554690
121cellular response to interleukin-15 (GO:0071350)2.92732014
122detection of biotic stimulus (GO:0009595)2.92518430
123protein K48-linked deubiquitination (GO:0071108)2.90604415
124proline biosynthetic process (GO:0006561)2.90598864
125tetrapyrrole metabolic process (GO:0033013)2.89618266
126regulation of interferon-beta biosynthetic process (GO:0045357)2.89618002
127response to host (GO:0075136)2.89086518
128response to host defenses (GO:0052200)2.89086518
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.89086518
130indole-containing compound catabolic process (GO:0042436)2.88679690
131indolalkylamine catabolic process (GO:0046218)2.88679690
132tryptophan catabolic process (GO:0006569)2.88679690
133photoreceptor cell maintenance (GO:0045494)2.88607838
134regulation of alpha-beta T cell proliferation (GO:0046640)2.88585294
135triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87858163
136regulation of sister chromatid cohesion (GO:0007063)2.87577802
137positive regulation of receptor recycling (GO:0001921)2.86643947
138embryonic process involved in female pregnancy (GO:0060136)2.86406896
139negative regulation of adaptive immune response (GO:0002820)2.86327747
140response to lead ion (GO:0010288)2.86195721
141myeloid cell activation involved in immune response (GO:0002275)2.86157301
142positive regulation of insulin receptor signaling pathway (GO:0046628)2.85521480
143cytoplasmic mRNA processing body assembly (GO:0033962)2.83607426
144regulation of clathrin-mediated endocytosis (GO:2000369)2.82903898
145Peyers patch development (GO:0048541)2.82770590
146mucosal-associated lymphoid tissue development (GO:0048537)2.82770590
147histone lysine demethylation (GO:0070076)2.82331829
148respiratory burst (GO:0045730)2.80686992
149antigen processing and presentation via MHC class Ib (GO:0002475)2.80336734
150regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79554337
151phototransduction (GO:0007602)2.78884120
152homocysteine metabolic process (GO:0050667)2.78184508
153detection of bacterium (GO:0016045)2.77461088
154detection of light stimulus (GO:0009583)2.76236724
155regulation of amyloid precursor protein catabolic process (GO:1902991)2.76006091
156definitive hemopoiesis (GO:0060216)2.75895317
157nitrogen cycle metabolic process (GO:0071941)2.75839633
158tryptophan metabolic process (GO:0006568)2.73738524
159amino-acid betaine metabolic process (GO:0006577)2.73605060
160positive regulation of mitotic sister chromatid separation (GO:1901970)2.72613077
161positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72613077
162positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72613077
163detection of light stimulus involved in sensory perception (GO:0050962)2.72392553
164detection of light stimulus involved in visual perception (GO:0050908)2.72392553
165proline metabolic process (GO:0006560)2.71906423
166phototransduction, visible light (GO:0007603)2.70508965
167fatty acid transmembrane transport (GO:1902001)2.69354072
168response to arsenic-containing substance (GO:0046685)2.69254707
169carnitine shuttle (GO:0006853)2.66881524
170negative regulation of cholesterol transport (GO:0032375)2.66577160
171negative regulation of sterol transport (GO:0032372)2.66577160
172platelet formation (GO:0030220)2.63262395
173high-density lipoprotein particle remodeling (GO:0034375)2.63244349
174macroautophagy (GO:0016236)2.62961402
175acylglycerol homeostasis (GO:0055090)2.62003982
176triglyceride homeostasis (GO:0070328)2.62003982
177heme transport (GO:0015886)2.61589851
178plasma lipoprotein particle organization (GO:0071827)2.61065338
179negative regulation of fibrinolysis (GO:0051918)2.60958697
180negative regulation of histone methylation (GO:0031061)2.59929565
181glutamate metabolic process (GO:0006536)2.58919765
182regulation of translational fidelity (GO:0006450)2.58379495
183cholesterol efflux (GO:0033344)2.58321646
184histone H3-K9 demethylation (GO:0033169)2.58228950
185aspartate family amino acid catabolic process (GO:0009068)2.56491190
186DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.52306696
187histone H3-K36 demethylation (GO:0070544)2.52144040
188complement activation, alternative pathway (GO:0006957)2.51041194
189response to dexamethasone (GO:0071548)2.50515718
190protein-lipid complex subunit organization (GO:0071825)2.50434820
191valine metabolic process (GO:0006573)2.50142805
192negative regulation of fatty acid metabolic process (GO:0045922)2.49199510
193regulation of protein activation cascade (GO:2000257)2.49050320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.54431945
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.08963987
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.85476636
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.67572709
5E2F7_22180533_ChIP-Seq_HELA_Human3.57424087
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.40261170
7RUNX_20019798_ChIP-Seq_JUKART_Human3.19784558
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.18079005
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.01638812
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.00090887
11* MYC_22102868_ChIP-Seq_BL_Human2.97532471
12GATA1_22025678_ChIP-Seq_K562_Human2.90696941
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90084246
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89914442
15MYB_26560356_Chip-Seq_TH2_Human2.88436324
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.81565569
17TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.81564107
18* GATA1_19941826_ChIP-Seq_K562_Human2.75577317
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.69464771
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56763603
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.56069188
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55893307
23GATA1_19941827_ChIP-Seq_MEL_Mouse2.53202089
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.47752341
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40106524
26SPI1_23127762_ChIP-Seq_K562_Human2.37367029
27ZNF263_19887448_ChIP-Seq_K562_Human2.30063543
28* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29456084
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28218391
30VDR_21846776_ChIP-Seq_THP-1_Human2.26396706
31* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.23861195
32TCF7_22412390_ChIP-Seq_EML_Mouse2.20679335
33* KDM2B_26808549_Chip-Seq_DND41_Human2.14155428
34* SPI1_23547873_ChIP-Seq_NB4_Human2.13299073
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09344166
36SCL_19346495_ChIP-Seq_HPC-7_Human2.04862824
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02635254
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98385475
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98113619
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95537914
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94779011
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.90746145
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87870115
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.87169543
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78989020
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.77081409
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76862043
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.75281845
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72095474
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.71136070
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.70010931
52* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69987160
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.68100176
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.65857229
55* GATA2_19941826_ChIP-Seq_K562_Human1.63974187
56* UTX_26944678_Chip-Seq_JUKART_Human1.62515649
57KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.62164540
58CLOCK_20551151_ChIP-Seq_293T_Human1.60320544
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59936022
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59716324
61* KDM2B_26808549_Chip-Seq_K562_Human1.59106598
62PU_27001747_Chip-Seq_BMDM_Mouse1.57663756
63LXR_22292898_ChIP-Seq_THP-1_Human1.57635305
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.57627089
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57201579
66* MAF_26560356_Chip-Seq_TH1_Human1.50719835
67* NCOR1_26117541_ChIP-Seq_K562_Human1.45629104
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43593852
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39791509
70VDR_24787735_ChIP-Seq_THP-1_Human1.39322152
71RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37677703
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35998756
73* CREB1_26743006_Chip-Seq_LNCaP_Human1.33562616
74* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31334444
75FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30448100
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30248616
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29367834
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28556324
79DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27954093
80GATA3_26560356_Chip-Seq_TH2_Human1.27916830
81E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26266818
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26151061
83* GATA6_25053715_ChIP-Seq_YYC3_Human1.25583769
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25232022
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.24136303
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23826109
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.21278123
88* FOXA2_19822575_ChIP-Seq_HepG2_Human1.20590472
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19242722
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19094105
91GATA1_19941827_ChIP-Seq_MEL86_Mouse1.18894408
92BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15361980
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.12979455
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12178009
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11862882
96CIITA_25753668_ChIP-Seq_RAJI_Human1.11822439
97* CHD1_26751641_Chip-Seq_LNCaP_Human1.11818714
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10556779
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10392325
100P68_20966046_ChIP-Seq_HELA_Human1.09607676
101BP1_19119308_ChIP-ChIP_Hs578T_Human1.09502475
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08794430
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08410348
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07861813
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07675956
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06890145
107* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06542842
108* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06534111
109SALL1_21062744_ChIP-ChIP_HESCs_Human1.05485211
110NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05415616
111FOXO3_23340844_ChIP-Seq_DLD1_Human1.05258882
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03885253
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02905232
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02854041
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02684817
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02087558
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01920077
118KDM5A_27292631_Chip-Seq_BREAST_Human1.01723784
119GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01135550
120* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01119145
121ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01062029
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99566836
123VDR_24763502_ChIP-Seq_THP-1_Human0.98673135
124* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98523550
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98325475
126TFEB_21752829_ChIP-Seq_HELA_Human0.98283708
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97226785
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97167372
129ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95807510
130* ATF3_27146783_Chip-Seq_COLON_Human0.94984143
131CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94415103
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94283135
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93607791
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91115433
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90987884
136* MAF_26560356_Chip-Seq_TH2_Human0.88659502
137* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88263630
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87358509
139RUNX1_22412390_ChIP-Seq_EML_Mouse0.87207340
140* MYB_26560356_Chip-Seq_TH1_Human0.86750684
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85058258
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83738858
143HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83727086
144SMRT_27268052_Chip-Seq_Bcells_Human0.83232662
145PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77608172
146KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.77433259
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74783490
148ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74524460
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74299416
150GATA3_26560356_Chip-Seq_TH1_Human0.73363205
151FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70569176
152SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70210141
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.68685099
154TP53_16413492_ChIP-PET_HCT116_Human0.68340621
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.67841522
156TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.67798897
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.66659709
158* SALL4_22934838_ChIP-ChIP_CD34+_Human0.66370089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo5.55496950
2MP0008260_abnormal_autophagy4.53033854
3MP0000569_abnormal_digit_pigmentation4.19026105
4MP0002139_abnormal_hepatobiliary_system3.97011919
5MP0003011_delayed_dark_adaptation3.87028740
6MP0005360_urolithiasis3.80556864
7MP0004147_increased_porphyrin_level3.55562495
8MP0005365_abnormal_bile_salt3.47029886
9MP0005551_abnormal_eye_electrophysiolog3.46800680
10MP0003763_abnormal_thymus_physiology3.17227884
11MP0005085_abnormal_gallbladder_physiolo3.05172110
12MP0005451_abnormal_body_composition3.01894546
13MP0006072_abnormal_retinal_apoptosis2.95758666
14MP0003724_increased_susceptibility_to2.85564430
15MP0001835_abnormal_antigen_presentation2.84508866
16MP0005083_abnormal_biliary_tract2.78999934
17MP0003303_peritoneal_inflammation2.75333211
18MP0003252_abnormal_bile_duct2.56375577
19MP0005253_abnormal_eye_physiology2.56340172
20MP0003787_abnormal_imprinting2.55448342
21MP0004381_abnormal_hair_follicle2.43936736
22MP0003705_abnormal_hypodermis_morpholog2.37935209
23MP0001800_abnormal_humoral_immune2.37915781
24MP0003172_abnormal_lysosome_physiology2.24589637
25MP0002396_abnormal_hematopoietic_system2.19887925
26MP0002398_abnormal_bone_marrow2.18818795
27MP0000685_abnormal_immune_system2.13781511
28MP0003436_decreased_susceptibility_to2.13480184
29MP0003221_abnormal_cardiomyocyte_apopto2.00561732
30MP0002420_abnormal_adaptive_immunity1.93880045
31MP0008875_abnormal_xenobiotic_pharmacok1.90869585
32MP0001819_abnormal_immune_cell1.90826166
33MP0002722_abnormal_immune_system1.88313255
34MP0005076_abnormal_cell_differentiation1.88108661
35MP0005671_abnormal_response_to1.85752342
36MP0000689_abnormal_spleen_morphology1.85193692
37MP0002723_abnormal_immune_serum1.84721869
38MP0002419_abnormal_innate_immunity1.84299315
39MP0005025_abnormal_response_to1.82801624
40MP0000015_abnormal_ear_pigmentation1.82387005
41MP0001324_abnormal_eye_pigmentation1.79003084
42MP0002452_abnormal_antigen_presenting1.77257103
43MP0005000_abnormal_immune_tolerance1.76999105
44MP0002653_abnormal_ependyma_morphology1.76444384
45MP0005075_abnormal_melanosome_morpholog1.75355135
46MP0000716_abnormal_immune_system1.72741365
47MP0002405_respiratory_system_inflammati1.71931298
48MP0010329_abnormal_lipoprotein_level1.71046820
49MP0004883_abnormal_blood_vessel1.69034140
50MP0009278_abnormal_bone_marrow1.65799733
51MP0003300_gastrointestinal_ulcer1.65192552
52MP0005195_abnormal_posterior_eye1.63115671
53MP0005391_vision/eye_phenotype1.57928188
54MP0004233_abnormal_muscle_weight1.55898365
55MP0000609_abnormal_liver_physiology1.53167380
56MP0002429_abnormal_blood_cell1.53059568
57MP0001790_abnormal_immune_system1.52165982
58MP0005387_immune_system_phenotype1.52165982
59MP0005310_abnormal_salivary_gland1.51963820
60MP0002009_preneoplasia1.47111355
61MP0005174_abnormal_tail_pigmentation1.46231728
62MP0003866_abnormal_defecation1.44203475
63MP0009785_altered_susceptibility_to1.43989768
64MP0003828_pulmonary_edema1.40923609
65MP0003111_abnormal_nucleus_morphology1.39854596
66MP0005187_abnormal_penis_morphology1.39794060
67MP0008877_abnormal_DNA_methylation1.38673211
68MP0004947_skin_inflammation1.38328549
69MP0004264_abnormal_extraembryonic_tissu1.36887487
70MP0001666_abnormal_nutrient_absorption1.35398822
71MP0009053_abnormal_anal_canal1.34604678
72MP0010030_abnormal_orbit_morphology1.30278499
73MP0005397_hematopoietic_system_phenotyp1.30015494
74MP0001545_abnormal_hematopoietic_system1.30015494
75MP0002006_tumorigenesis1.29109242
76MP0003890_abnormal_embryonic-extraembry1.27989350
77MP0009333_abnormal_splenocyte_physiolog1.27241040
78MP0004019_abnormal_vitamin_homeostasis1.26976573
79MP0002138_abnormal_hepatobiliary_system1.22772207
80MP0010307_abnormal_tumor_latency1.22094790
81MP0010352_gastrointestinal_tract_polyps1.20084749
82MP0009840_abnormal_foam_cell1.18566826
83MP0002166_altered_tumor_susceptibility1.15954755
84MP0000858_altered_metastatic_potential1.14547476
85MP0003690_abnormal_glial_cell1.13038488
86MP0008057_abnormal_DNA_replication1.10768503
87MP0002086_abnormal_extraembryonic_tissu1.09956877
88MP0002332_abnormal_exercise_endurance1.09890796
89MP0001851_eye_inflammation1.09072859
90MP0008961_abnormal_basal_metabolism1.09025402
91MP0001764_abnormal_homeostasis1.08760983
92MP0004130_abnormal_muscle_cell1.08099313
93MP0001845_abnormal_inflammatory_respons1.05708845
94MP0004197_abnormal_fetal_growth/weight/1.04207653
95MP0005319_abnormal_enzyme/_coenzyme1.03992514
96MP0002132_abnormal_respiratory_system1.03063043
97MP0010630_abnormal_cardiac_muscle0.99261117
98MP0000598_abnormal_liver_morphology0.98919776
99MP0002088_abnormal_embryonic_growth/wei0.96542468
100MP0003984_embryonic_growth_retardation0.95892710
101MP0010155_abnormal_intestine_physiology0.95211908
102MP0008775_abnormal_heart_ventricle0.94858218
103MP0003191_abnormal_cellular_cholesterol0.94629584
104MP0002697_abnormal_eye_size0.94018805
105MP0004484_altered_response_of0.93472538
106MP0005220_abnormal_exocrine_pancreas0.92849485
107MP0005332_abnormal_amino_acid0.91765041
108MP0003121_genomic_imprinting0.91612044
109MP0001697_abnormal_embryo_size0.91186985
110MP0005248_abnormal_Harderian_gland0.91084776
111MP0005380_embryogenesis_phenotype0.90928389
112MP0001672_abnormal_embryogenesis/_devel0.90928389
113MP0010094_abnormal_chromosome_stability0.89986205
114MP0008789_abnormal_olfactory_epithelium0.89398027
115MP0005621_abnormal_cell_physiology0.89216796
116MP0003567_abnormal_fetal_cardiomyocyte0.87879010
117MP0000350_abnormal_cell_proliferation0.87020257
118MP0005164_abnormal_response_to0.86605466
119MP0009672_abnormal_birth_weight0.86334128
120MP0006082_CNS_inflammation0.86301007
121MP0004185_abnormal_adipocyte_glucose0.85080376
122MP0002118_abnormal_lipid_homeostasis0.84883413
123MP0003868_abnormal_feces_composition0.83897449
124MP0003091_abnormal_cell_migration0.82018958
125MP0005666_abnormal_adipose_tissue0.81923467
126MP0005636_abnormal_mineral_homeostasis0.81310613
127MP0001293_anophthalmia0.80832704
128MP0000465_gastrointestinal_hemorrhage0.80522182
129MP0000371_diluted_coat_color0.79073732
130MP0002092_abnormal_eye_morphology0.78697935
131MP0002148_abnormal_hypersensitivity_rea0.78449821
132MP0001730_embryonic_growth_arrest0.77866922
133MP0002084_abnormal_developmental_patter0.77762720
134MP0003077_abnormal_cell_cycle0.77084437
135MP0009703_decreased_birth_body0.75433859
136MP0005501_abnormal_skin_physiology0.75091515
137MP0009643_abnormal_urine_homeostasis0.74755078
138MP0005394_taste/olfaction_phenotype0.74127657
139MP0005499_abnormal_olfactory_system0.74127657
140MP0002928_abnormal_bile_duct0.73353385
141MP0001915_intracranial_hemorrhage0.73045235
142MP0002090_abnormal_vision0.71707749
143MP0000266_abnormal_heart_morphology0.70782762
144MP0009763_increased_sensitivity_to0.70381480
145MP0009765_abnormal_xenobiotic_induced0.69918501
146MP0002080_prenatal_lethality0.69726747
147MP0001849_ear_inflammation0.69656208
148MP0003806_abnormal_nucleotide_metabolis0.68771827
149MP0002085_abnormal_embryonic_tissue0.68108289
150MP0002269_muscular_atrophy0.67960064
151MP0000604_amyloidosis0.67777933
152MP0004808_abnormal_hematopoietic_stem0.67620131
153MP0005384_cellular_phenotype0.67425357
154MP0002229_neurodegeneration0.67400926
155MP0003329_amyloid_beta_deposits0.67250689
156MP0001533_abnormal_skeleton_physiology0.66836515
157MP0003632_abnormal_nervous_system0.66805777
158MP0004087_abnormal_muscle_fiber0.65979097
159MP0008995_early_reproductive_senescence0.65447980
160MP0002971_abnormal_brown_adipose0.65083927
161MP0005464_abnormal_platelet_physiology0.65027404
162MP0009764_decreased_sensitivity_to0.64040000
163MP0001663_abnormal_digestive_system0.63824247
164MP0009115_abnormal_fat_cell0.62963065
165MP0008469_abnormal_protein_level0.62891988
166MP0005409_darkened_coat_color0.62580090
167MP0005376_homeostasis/metabolism_phenot0.62519510
168MP0002970_abnormal_white_adipose0.62418830
169MP0005408_hypopigmentation0.62401291
170MP0005266_abnormal_metabolism0.62268325
171MP0008770_decreased_survivor_rate0.61809381
172MP0008874_decreased_physiological_sensi0.61651024
173MP0003183_abnormal_peptide_metabolism0.61531566
174MP0000703_abnormal_thymus_morphology0.60990877
175MP0002019_abnormal_tumor_incidence0.60545892
176MP0001853_heart_inflammation0.55806325

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)7.38352624
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.95590903
3* Poikilocytosis (HP:0004447)6.36484996
4Congenital stationary night blindness (HP:0007642)6.33279986
5Chorioretinal atrophy (HP:0000533)5.55291122
6T lymphocytopenia (HP:0005403)5.38564581
7Pendular nystagmus (HP:0012043)5.32900638
8Absent rod-and cone-mediated responses on ERG (HP:0007688)5.24143267
9Pigmentary retinal degeneration (HP:0001146)5.22127979
10Recurrent bacterial skin infections (HP:0005406)5.18639413
11Bony spicule pigmentary retinopathy (HP:0007737)5.14641895
12Abnormality of the heme biosynthetic pathway (HP:0010472)4.96075597
13Abnormality of T cell number (HP:0011839)4.93716360
14Central scotoma (HP:0000603)4.93263237
15Acanthocytosis (HP:0001927)4.85992598
16Abnormal rod and cone electroretinograms (HP:0008323)4.81397324
17Eczematoid dermatitis (HP:0000976)4.59852836
18Recurrent abscess formation (HP:0002722)4.52748139
19Reticulocytosis (HP:0001923)4.38019238
20Posterior subcapsular cataract (HP:0007787)4.30404744
21Gastrointestinal infarctions (HP:0005244)4.15111342
22Cholelithiasis (HP:0001081)4.01224209
23Abolished electroretinogram (ERG) (HP:0000550)3.90344426
24Abnormality of macular pigmentation (HP:0008002)3.90036450
25Scotoma (HP:0000575)3.89193866
26Recurrent fungal infections (HP:0002841)3.74568587
27Slow saccadic eye movements (HP:0000514)3.59215365
28Abnormal gallbladder morphology (HP:0012437)3.55087241
29Hypochromic anemia (HP:0001931)3.54257591
30Optic neuritis (HP:0100653)3.50365272
31Retrobulbar optic neuritis (HP:0100654)3.50365272
32Spontaneous hematomas (HP:0007420)3.44471701
33Gingival bleeding (HP:0000225)3.41174959
34Abnormality of the fingertips (HP:0001211)3.38579520
35Myositis (HP:0100614)3.37963696
36Recurrent viral infections (HP:0004429)3.30827396
37Abnormality of T cells (HP:0002843)3.29156068
38Orchitis (HP:0100796)3.28168720
39Hyperbilirubinemia (HP:0002904)3.26559091
40Gingivitis (HP:0000230)3.25461608
41Recurrent skin infections (HP:0001581)3.24760941
42Type II diabetes mellitus (HP:0005978)3.24140475
43Cone-rod dystrophy (HP:0000548)3.21882106
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.13903799
45Deep venous thrombosis (HP:0002625)3.11881309
46Postural instability (HP:0002172)3.10856168
47Dyschromatopsia (HP:0007641)3.09221236
48Insomnia (HP:0100785)3.08374819
49Macular degeneration (HP:0000608)3.08169654
50Prolonged bleeding time (HP:0003010)3.00707471
51Decreased central vision (HP:0007663)2.99378016
52Subcapsular cataract (HP:0000523)2.96174607
53Subacute progressive viral hepatitis (HP:0006572)2.96004413
54Recurrent gram-negative bacterial infections (HP:0005420)2.94590567
55Leukocytosis (HP:0001974)2.92536846
56Recurrent cutaneous fungal infections (HP:0011370)2.92449645
57Chronic mucocutaneous candidiasis (HP:0002728)2.92449645
58Keratoconjunctivitis sicca (HP:0001097)2.89456457
59Arterial thrombosis (HP:0004420)2.86273075
60Orthostatic hypotension (HP:0001278)2.86153785
61Visual hallucinations (HP:0002367)2.83517119
62Vitreoretinal degeneration (HP:0000655)2.79503897
63Polycythemia (HP:0001901)2.78876017
64Epistaxis (HP:0000421)2.74068460
65Severe visual impairment (HP:0001141)2.73866530
66Encephalitis (HP:0002383)2.71130444
67Meningitis (HP:0001287)2.70995294
68Diaphragmatic weakness (HP:0009113)2.66915767
69Papillary thyroid carcinoma (HP:0002895)2.66819431
70Viral hepatitis (HP:0006562)2.65688248
71Hepatocellular carcinoma (HP:0001402)2.62566945
72Keratoconjunctivitis (HP:0001096)2.62090510
73Microcytic anemia (HP:0001935)2.61569790
74Chronic obstructive pulmonary disease (HP:0006510)2.60658701
75Obstructive lung disease (HP:0006536)2.60658701
76Attenuation of retinal blood vessels (HP:0007843)2.60012608
77Chest pain (HP:0100749)2.59217428
78Colitis (HP:0002583)2.59198936
79Cellulitis (HP:0100658)2.58291380
80Autoimmune hemolytic anemia (HP:0001890)2.58044255
81Abnormality of the gallbladder (HP:0005264)2.57862503
82Stomatitis (HP:0010280)2.55927991
83Intrahepatic cholestasis (HP:0001406)2.55139515
84Elevated erythrocyte sedimentation rate (HP:0003565)2.53600917
85Abnormality of macrophages (HP:0004311)2.52560019
86Inflammation of the large intestine (HP:0002037)2.50071232
87Vasculitis (HP:0002633)2.49281391
88Granulocytopenia (HP:0001913)2.48646320
89Peritonitis (HP:0002586)2.48473393
90Heterotopia (HP:0002282)2.43684914
91Urticaria (HP:0001025)2.42601534
92Mediastinal lymphadenopathy (HP:0100721)2.41171977
93Gastrointestinal inflammation (HP:0004386)2.40530656
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40133803
95Photophobia (HP:0000613)2.37880697
96Eosinophilia (HP:0001880)2.37226002
97Abnormality of reticulocytes (HP:0004312)2.33445825
98Cholecystitis (HP:0001082)2.31585168
99Abnormal gallbladder physiology (HP:0012438)2.31585168
100Acute myeloid leukemia (HP:0004808)2.30951499
101Resting tremor (HP:0002322)2.30853871
102Conjunctival telangiectasia (HP:0000524)2.27918582
103Volvulus (HP:0002580)2.25105456
104Hypoplasia of the thymus (HP:0000778)2.24143736
105Osteomyelitis (HP:0002754)2.23841341
106Recurrent bronchitis (HP:0002837)2.22375484
107Panhypogammaglobulinemia (HP:0003139)2.20170929
108Abnormality of eosinophils (HP:0001879)2.20145125
109Constricted visual fields (HP:0001133)2.20094173
110IgM deficiency (HP:0002850)2.19926317
111Xanthomatosis (HP:0000991)2.19126950
112Periodontitis (HP:0000704)2.17587144
113Hypobetalipoproteinemia (HP:0003563)2.16986545
114Macroorchidism (HP:0000053)2.15180102
115Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14081437
116Fatigue (HP:0012378)2.11695265
117Acute hepatic failure (HP:0006554)2.11508414
118Ketosis (HP:0001946)2.10444627
119Anorexia (HP:0002039)2.09414507
120Pustule (HP:0200039)2.05042514
121Keratoconus (HP:0000563)2.04891101
122Increased corneal curvature (HP:0100692)2.04891101
123Aplasia/Hypoplasia of the thymus (HP:0010515)2.03911177
124Papilloma (HP:0012740)2.03770567
125Verrucae (HP:0200043)2.03770567
126IgA deficiency (HP:0002720)2.02233842
127Abnormal platelet volume (HP:0011876)2.01819312
128Lymphopenia (HP:0001888)2.01790009
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.98108361
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97835021
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.97824129
132Osteomalacia (HP:0002749)1.94270608
133Pancreatic islet-cell hyperplasia (HP:0004510)1.94118911
134Abnormality of the peritoneum (HP:0002585)1.93876390
135Hyperammonemia (HP:0001987)1.93822727
136Hemoptysis (HP:0002105)1.93593407
137Paralysis (HP:0003470)1.92910633
138Abnormality of T cell physiology (HP:0011840)1.92358562
139Neonatal hypoglycemia (HP:0001998)1.92340211
140Abnormality of the common coagulation pathway (HP:0010990)1.88894327
141Pulmonary embolism (HP:0002204)1.88480020
142Hyperacusis (HP:0010780)1.87220028
143Cortical dysplasia (HP:0002539)1.86925321
144Amaurosis fugax (HP:0100576)1.86494063
145Severe combined immunodeficiency (HP:0004430)1.85676997
146Hypolipoproteinemia (HP:0010981)1.85430466
147Hypoalphalipoproteinemia (HP:0003233)1.85298167
148Cerebral inclusion bodies (HP:0100314)1.85162137
149Back pain (HP:0003418)1.84527557
150Autoimmune thrombocytopenia (HP:0001973)1.83370563
151Dysautonomia (HP:0002459)1.83083990
152Dysmetric saccades (HP:0000641)1.81599004
153Pulmonary infiltrates (HP:0002113)1.81233016
154Ketoacidosis (HP:0001993)1.80799834
155Pseudobulbar signs (HP:0002200)1.79806580
156Abnormality of the pancreatic islet cells (HP:0006476)1.79432309
157Abnormality of endocrine pancreas physiology (HP:0012093)1.79432309
158Elfin facies (HP:0004428)1.78635493
159Complement deficiency (HP:0004431)1.77447446
160Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75231599
161Short 4th metacarpal (HP:0010044)1.75231599
162Hypoglycemic coma (HP:0001325)1.73099819
163Progressive visual loss (HP:0000529)1.71862124
164Abnormality of glutamine family amino acid metabolism (HP:0010902)1.71771350
165Abnormality of the 4th metacarpal (HP:0010012)1.70733366
166Hyperlipoproteinemia (HP:0010980)1.69409700
167Generalized hyperpigmentation (HP:0007440)1.65267946
168Renovascular hypertension (HP:0100817)1.62995112
169Prominent nose (HP:0000448)1.62189900
170Esophageal varix (HP:0002040)1.61841852
171Hyperglycinuria (HP:0003108)1.60855064
172Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.58078474
173Myoglobinuria (HP:0002913)1.52577278
174Hypercholesterolemia (HP:0003124)1.51069020
175Epidermoid cyst (HP:0200040)1.50769469
176Abnormality of the lower motor neuron (HP:0002366)1.49977164
177Spastic diplegia (HP:0001264)1.49611654
178Lymphangioma (HP:0100764)1.49394766
179Obsessive-compulsive behavior (HP:0000722)1.49028882
180Increased nuchal translucency (HP:0010880)1.45374384
181Myocardial infarction (HP:0001658)1.45230956
182Short 5th finger (HP:0009237)1.45033655
183Gout (HP:0001997)1.42422629
184Truncal obesity (HP:0001956)1.42179628
185Childhood onset (HP:0011463)1.42118755
186Abnormality of glycine metabolism (HP:0010895)1.41629534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.12576599
2MAP3K103.95678327
3TRIB33.44796191
4CDK123.30532629
5EEF2K2.91985072
6PKN22.88521772
7ICK2.82843174
8FGR2.46112332
9BLK2.41350134
10IKBKE2.15974581
11PRPF4B2.12920924
12DYRK1B2.00617867
13SIK11.98872536
14CDK61.98594373
15WNK11.97710672
16CAMK1D1.96842639
17TAOK31.95112767
18LATS11.92265969
19STK41.89734777
20JAK31.88297586
21RIPK11.87618105
22SYK1.82594034
23TXK1.79164922
24FES1.79069299
25BTK1.76986593
26IRAK41.72716877
27CAMK1G1.68551056
28MAP3K21.63433716
29CDC71.61966377
30NEK21.55195618
31PTK61.49161702
32PTK2B1.48016053
33KSR21.46983795
34BMPR21.44746313
35MAPK111.42668913
36BRD41.40926471
37PRKAA11.40142518
38MAP3K61.39721351
39MAP3K141.38836820
40GRK51.38383623
41PDGFRA1.36819736
42ZAP701.32241163
43ERN11.29233270
44MARK21.27989609
45HCK1.27767274
46STK101.26924995
47JAK11.26904613
48MTOR1.26623575
49FGFR41.26387485
50TEC1.26044150
51MAP3K11.25517998
52MARK31.24448902
53ITK1.24372049
54KSR11.24294039
55PIK3CG1.22735794
56YES11.19686298
57EIF2AK11.17632076
58NLK1.16169909
59CDK41.15574534
60NEK11.15337612
61PIM11.15306781
62DYRK31.14774426
63SGK31.13577386
64GRK11.12123308
65BCKDK1.09721131
66PINK11.09214626
67MAP3K131.08776611
68CDK91.08005655
69MAP3K71.06822189
70LYN1.06771810
71PLK21.04843866
72TAOK11.04135375
73BMX1.03910597
74TTN1.03182648
75CLK11.02558572
76HIPK21.02032949
77IRAK10.99566976
78RAF10.98503981
79STK30.98102351
80MAP4K10.97539575
81DDR20.96124519
82MAP3K30.95683579
83PRKAA20.94992333
84RPS6KB20.93598436
85LCK0.93514990
86JAK20.90003180
87CAMKK20.89386579
88DYRK1A0.87936434
89CDC42BPA0.86977150
90SIK20.83759558
91IRAK20.82723973
92GRK60.79524868
93DMPK0.77821750
94TRPM70.77088063
95MAP3K110.77072494
96MAP2K30.76722447
97CHUK0.75866102
98FGFR30.74996416
99INSRR0.74465866
100TGFBR20.74014115
101TAOK20.73776105
102PRKD20.73741804
103TYRO30.71518367
104STK110.70132410
105MATK0.67643244
106CSK0.66910249
107MAP3K80.65589413
108SGK20.65354588
109SCYL20.65189908
110PDGFRB0.62819722
111STK380.62337391
112MAPKAPK30.61785431
113EPHB10.61555935
114FLT30.61477535
115CHEK20.60762286
116CHEK10.59550380
117MAP3K50.59052748
118TLK10.58426286
119RPS6KA10.56875397
120TYK20.55765133
121LRRK20.55499075
122PDK10.55249082
123ATR0.54825279
124RPS6KL10.54221848
125RPS6KC10.54221848
126ATM0.54054719
127IKBKB0.53686863
128CAMKK10.53681484
129CDK20.53203933
130RET0.50070310
131AURKB0.50025868
132FRK0.48971552
133GSK3A0.48102884
134MELK0.47852256
135TNK20.47765395
136RPS6KA60.47331046
137MAPK140.46878116
138AKT20.44042519
139SGK10.43862454
140CSNK1D0.43705255
141ALK0.43545733
142PHKG10.43428108
143PHKG20.43428108
144FGFR10.43283931
145ERBB30.42128625
146NEK60.41883469
147CDK70.40699799
148PRKCH0.40557046
149CAMK40.40500877
150* CDK10.39150012
151SGK2230.39017155
152SGK4940.39017155
153FYN0.38540019
154PRKCQ0.35078170
155MAP2K40.34480928

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.66042226
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.18071281
3Nitrogen metabolism_Homo sapiens_hsa009102.99475018
4B cell receptor signaling pathway_Homo sapiens_hsa046622.78657137
5Lysine degradation_Homo sapiens_hsa003102.65162921
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.56903322
7Arginine biosynthesis_Homo sapiens_hsa002202.40550753
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.39163167
9Leishmaniasis_Homo sapiens_hsa051402.31475081
10T cell receptor signaling pathway_Homo sapiens_hsa046602.27525274
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18303539
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17626827
13Osteoclast differentiation_Homo sapiens_hsa043802.16931145
14Systemic lupus erythematosus_Homo sapiens_hsa053222.06543842
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.00204141
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00061785
17Fatty acid degradation_Homo sapiens_hsa000711.91750852
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.91362515
19Primary immunodeficiency_Homo sapiens_hsa053401.87376908
20Measles_Homo sapiens_hsa051621.87311395
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.85363304
22ABC transporters_Homo sapiens_hsa020101.83410025
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75362187
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.74801252
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74238296
26Tryptophan metabolism_Homo sapiens_hsa003801.71815048
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66992400
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.55459522
29Fatty acid metabolism_Homo sapiens_hsa012121.52422827
30Malaria_Homo sapiens_hsa051441.50535949
31Tuberculosis_Homo sapiens_hsa051521.50477784
32Renal cell carcinoma_Homo sapiens_hsa052111.49828110
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47624129
34Selenocompound metabolism_Homo sapiens_hsa004501.47067485
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43943761
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43656270
37Caffeine metabolism_Homo sapiens_hsa002321.42780148
38Chemokine signaling pathway_Homo sapiens_hsa040621.40376833
39Bile secretion_Homo sapiens_hsa049761.39193985
40Biosynthesis of amino acids_Homo sapiens_hsa012301.38767520
41VEGF signaling pathway_Homo sapiens_hsa043701.38164095
42Influenza A_Homo sapiens_hsa051641.36974581
43mTOR signaling pathway_Homo sapiens_hsa041501.35408799
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35183245
45Complement and coagulation cascades_Homo sapiens_hsa046101.34653744
46Platelet activation_Homo sapiens_hsa046111.34215180
47Chronic myeloid leukemia_Homo sapiens_hsa052201.32819160
48Inositol phosphate metabolism_Homo sapiens_hsa005621.32798136
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.27564433
50Apoptosis_Homo sapiens_hsa042101.25975586
51Thyroid cancer_Homo sapiens_hsa052161.23918729
52Toxoplasmosis_Homo sapiens_hsa051451.23231777
53Hematopoietic cell lineage_Homo sapiens_hsa046401.23051718
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.22820844
55PPAR signaling pathway_Homo sapiens_hsa033201.21280099
56Propanoate metabolism_Homo sapiens_hsa006401.20668552
57Fatty acid biosynthesis_Homo sapiens_hsa000611.17806321
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16981379
59Insulin resistance_Homo sapiens_hsa049311.16933173
60Hepatitis C_Homo sapiens_hsa051601.16580434
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12496440
62AMPK signaling pathway_Homo sapiens_hsa041521.11135809
63ErbB signaling pathway_Homo sapiens_hsa040121.09884889
64Notch signaling pathway_Homo sapiens_hsa043301.08697954
65TNF signaling pathway_Homo sapiens_hsa046681.07078003
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06944931
67Legionellosis_Homo sapiens_hsa051341.05555152
68Leukocyte transendothelial migration_Homo sapiens_hsa046701.05258592
69Circadian rhythm_Homo sapiens_hsa047101.02973991
70Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02833255
71Butanoate metabolism_Homo sapiens_hsa006501.02437006
72Non-small cell lung cancer_Homo sapiens_hsa052231.01925449
73Carbon metabolism_Homo sapiens_hsa012001.01383986
74Pyruvate metabolism_Homo sapiens_hsa006201.00232760
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99269875
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99183974
77Choline metabolism in cancer_Homo sapiens_hsa052310.98770693
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97608416
79Graft-versus-host disease_Homo sapiens_hsa053320.97455534
80HIF-1 signaling pathway_Homo sapiens_hsa040660.95421220
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.93077080
82Long-term potentiation_Homo sapiens_hsa047200.92530898
83Endometrial cancer_Homo sapiens_hsa052130.89789094
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.88835292
85beta-Alanine metabolism_Homo sapiens_hsa004100.87020900
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86502063
87Autoimmune thyroid disease_Homo sapiens_hsa053200.85345302
88Allograft rejection_Homo sapiens_hsa053300.85332848
89Fat digestion and absorption_Homo sapiens_hsa049750.84893176
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84003188
91mRNA surveillance pathway_Homo sapiens_hsa030150.79399712
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79156574
93Alcoholism_Homo sapiens_hsa050340.78140120
94Sulfur relay system_Homo sapiens_hsa041220.78002180
95Vitamin B6 metabolism_Homo sapiens_hsa007500.77315771
96Retinol metabolism_Homo sapiens_hsa008300.75735536
97Pancreatic cancer_Homo sapiens_hsa052120.75004583
98Peroxisome_Homo sapiens_hsa041460.74575642
99Staphylococcus aureus infection_Homo sapiens_hsa051500.74303681
100Adherens junction_Homo sapiens_hsa045200.73974948
101HTLV-I infection_Homo sapiens_hsa051660.73000949
102Insulin signaling pathway_Homo sapiens_hsa049100.72558631
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72229302
104Starch and sucrose metabolism_Homo sapiens_hsa005000.71902810
105Epstein-Barr virus infection_Homo sapiens_hsa051690.71572157
106Viral carcinogenesis_Homo sapiens_hsa052030.71255899
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.70665445
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70655532
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.70084701
110Bladder cancer_Homo sapiens_hsa052190.69893627
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.68825649
112GnRH signaling pathway_Homo sapiens_hsa049120.68645366
113Small cell lung cancer_Homo sapiens_hsa052220.68135670
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.68036469
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66594964
116One carbon pool by folate_Homo sapiens_hsa006700.65808137
117African trypanosomiasis_Homo sapiens_hsa051430.64270099
118Antigen processing and presentation_Homo sapiens_hsa046120.63964179
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62073392
120FoxO signaling pathway_Homo sapiens_hsa040680.61785255
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59918525
122Acute myeloid leukemia_Homo sapiens_hsa052210.59224786
123Glycerolipid metabolism_Homo sapiens_hsa005610.58152397
124Glucagon signaling pathway_Homo sapiens_hsa049220.57845735
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.57192113
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57096479
127MAPK signaling pathway_Homo sapiens_hsa040100.55924861
128Cell cycle_Homo sapiens_hsa041100.55081101
129Phenylalanine metabolism_Homo sapiens_hsa003600.52419485
130MicroRNAs in cancer_Homo sapiens_hsa052060.51482543
131Type II diabetes mellitus_Homo sapiens_hsa049300.50313586
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49972658
133Arginine and proline metabolism_Homo sapiens_hsa003300.48692640
134Shigellosis_Homo sapiens_hsa051310.47871024
135Estrogen signaling pathway_Homo sapiens_hsa049150.44830277
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44327082
137Regulation of autophagy_Homo sapiens_hsa041400.43810974
138Fructose and mannose metabolism_Homo sapiens_hsa000510.43019117
139Colorectal cancer_Homo sapiens_hsa052100.42972755
140Prostate cancer_Homo sapiens_hsa052150.42958533
141Dorso-ventral axis formation_Homo sapiens_hsa043200.42876117
142Type I diabetes mellitus_Homo sapiens_hsa049400.42763977
143Hippo signaling pathway_Homo sapiens_hsa043900.42375378
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.42269081
145Phagosome_Homo sapiens_hsa041450.41973437
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41566092
147Viral myocarditis_Homo sapiens_hsa054160.40518299
148Cholinergic synapse_Homo sapiens_hsa047250.40227125
149Ras signaling pathway_Homo sapiens_hsa040140.38115092
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35172954
151Hepatitis B_Homo sapiens_hsa051610.34230929
152Base excision repair_Homo sapiens_hsa034100.34178777
153Prolactin signaling pathway_Homo sapiens_hsa049170.33539836
154Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33478368
155Proteoglycans in cancer_Homo sapiens_hsa052050.33114495
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31881867
157Glioma_Homo sapiens_hsa052140.31109807
158Chemical carcinogenesis_Homo sapiens_hsa052040.30631342
159Basal cell carcinoma_Homo sapiens_hsa052170.30085108
160Herpes simplex infection_Homo sapiens_hsa051680.29861853
161Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29325942

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