EPB41L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.72298388
2central nervous system myelination (GO:0022010)7.72298388
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.04594356
4sodium ion export (GO:0071436)4.79616857
5ensheathment of neurons (GO:0007272)4.45790068
6axon ensheathment (GO:0008366)4.45790068
7myelination (GO:0042552)4.44299495
8fatty acid elongation (GO:0030497)4.39792454
9neuronal action potential propagation (GO:0019227)4.27543412
10synaptic vesicle maturation (GO:0016188)4.12596755
11establishment of mitochondrion localization (GO:0051654)4.09784254
12long-chain fatty acid biosynthetic process (GO:0042759)4.07994539
13neuron cell-cell adhesion (GO:0007158)3.82495569
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.74722563
15apical protein localization (GO:0045176)3.74371293
16negative regulation of neurotransmitter transport (GO:0051589)3.66915103
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.65068947
18synaptic vesicle exocytosis (GO:0016079)3.57407279
19regulation of synaptic vesicle exocytosis (GO:2000300)3.53177958
20negative regulation of neurotransmitter secretion (GO:0046929)3.51496326
21presynaptic membrane organization (GO:0097090)3.44169695
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40310417
23neurofilament cytoskeleton organization (GO:0060052)3.29762217
24glutamate secretion (GO:0014047)3.28936061
25adult walking behavior (GO:0007628)3.27974472
26positive regulation of neurotransmitter secretion (GO:0001956)3.24216085
27asymmetric protein localization (GO:0008105)3.22673369
28regulation of mononuclear cell migration (GO:0071675)3.20227939
29glycine transport (GO:0015816)3.18521337
30amino acid import (GO:0043090)3.16117945
31cell communication by electrical coupling (GO:0010644)3.15721155
32presynaptic membrane assembly (GO:0097105)3.13437171
33proline transport (GO:0015824)3.07638781
34L-amino acid import (GO:0043092)3.06418082
35neuromuscular process controlling posture (GO:0050884)3.05576373
36transmission of nerve impulse (GO:0019226)3.05512796
37negative regulation of protein localization to cell surface (GO:2000009)3.05222488
38detection of temperature stimulus involved in sensory perception (GO:0050961)3.03770633
39detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.03770633
40neurotransmitter-gated ion channel clustering (GO:0072578)3.03497732
41neuron recognition (GO:0008038)3.01272422
42response to methylmercury (GO:0051597)2.96643236
43positive regulation of neurotransmitter transport (GO:0051590)2.94599177
44regulation of collateral sprouting (GO:0048670)2.94169654
45peptidyl-tyrosine autophosphorylation (GO:0038083)2.93265360
46oligodendrocyte differentiation (GO:0048709)2.92112120
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91587094
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90754347
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.89728301
50photoreceptor cell differentiation (GO:0046530)2.88924372
51eye photoreceptor cell differentiation (GO:0001754)2.88924372
52regulation of synaptic vesicle transport (GO:1902803)2.88877966
53neuronal ion channel clustering (GO:0045161)2.85738995
54cellular potassium ion homeostasis (GO:0030007)2.85027108
55cellular sodium ion homeostasis (GO:0006883)2.84318390
56regulation of ARF protein signal transduction (GO:0032012)2.84174236
57positive regulation of potassium ion transport (GO:0043268)2.83977678
58protein localization to endosome (GO:0036010)2.83709264
59regulation of neurotransmitter secretion (GO:0046928)2.81483057
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80120206
61axonal fasciculation (GO:0007413)2.79064756
62vocalization behavior (GO:0071625)2.77961510
63protein localization to synapse (GO:0035418)2.77381268
64negative regulation of axonogenesis (GO:0050771)2.77333708
65detection of temperature stimulus (GO:0016048)2.76158360
66regulation of neuronal synaptic plasticity (GO:0048168)2.74385739
67organelle transport along microtubule (GO:0072384)2.73806849
68cellular response to thyroid hormone stimulus (GO:0097067)2.72647984
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72458975
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72232276
71dendritic spine morphogenesis (GO:0060997)2.71649959
72negative regulation of dendrite morphogenesis (GO:0050774)2.69671374
73positive regulation of oligodendrocyte differentiation (GO:0048714)2.69018522
74axon development (GO:0061564)2.68928191
75mating behavior (GO:0007617)2.65901279
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.65675206
77substantia nigra development (GO:0021762)2.65353172
78locomotory exploration behavior (GO:0035641)2.65083887
79protein palmitoylation (GO:0018345)2.64907889
80gamma-aminobutyric acid transport (GO:0015812)2.63967649
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.63398408
82dendrite morphogenesis (GO:0048813)2.63119325
83response to redox state (GO:0051775)2.62741836
84regulation of voltage-gated calcium channel activity (GO:1901385)2.62142738
85mitochondrion transport along microtubule (GO:0047497)2.61411868
86establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61411868
87negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61184717
88regulation of synapse structural plasticity (GO:0051823)2.60826876
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60711320
90potassium ion homeostasis (GO:0055075)2.59620187
91neurotransmitter secretion (GO:0007269)2.59319103
92ionotropic glutamate receptor signaling pathway (GO:0035235)2.58921612
93neuron remodeling (GO:0016322)2.58907851
94nerve growth factor signaling pathway (GO:0038180)2.58674648
95layer formation in cerebral cortex (GO:0021819)2.58414965
96adenosine receptor signaling pathway (GO:0001973)2.57715614
97regulation of synaptic plasticity (GO:0048167)2.57470571
98astrocyte development (GO:0014002)2.56847098
99negative regulation of JUN kinase activity (GO:0043508)2.56201842
100exploration behavior (GO:0035640)2.55987001
101neuron-neuron synaptic transmission (GO:0007270)2.54902482
102glycerophospholipid catabolic process (GO:0046475)2.54773825
103positive regulation of cellular amide metabolic process (GO:0034250)2.54049990
104glycosphingolipid catabolic process (GO:0046479)2.53892729
105negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.52983290
106neurotransmitter transport (GO:0006836)2.52288699
107axon cargo transport (GO:0008088)2.52257964
108negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52253708
109* myelin maintenance (GO:0043217)2.52088122
110membrane hyperpolarization (GO:0060081)2.51888405
111cerebellar Purkinje cell differentiation (GO:0021702)2.51816145
112peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51762184
113vesicle transport along microtubule (GO:0047496)2.51536691
114regulation of macrophage chemotaxis (GO:0010758)2.50661069
115cholesterol biosynthetic process (GO:0006695)2.50536659
116adult locomotory behavior (GO:0008344)2.50410123
117synaptic transmission, glutamatergic (GO:0035249)2.49612847
118regulation of glutamate receptor signaling pathway (GO:1900449)2.49286171
119potassium ion import (GO:0010107)2.48591930
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.46952031
121macrophage activation involved in immune response (GO:0002281)2.46942766
122regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46519658
123neurotransmitter uptake (GO:0001504)2.45855622
124cell migration in hindbrain (GO:0021535)2.45260160
125regulation of neurotransmitter transport (GO:0051588)2.44188406
126cerebellar granule cell differentiation (GO:0021707)2.44040851
127regulation of early endosome to late endosome transport (GO:2000641)2.42748048
128response to parathyroid hormone (GO:0071107)2.42524006
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42135940
130glutamate receptor signaling pathway (GO:0007215)2.40336387
131neuromuscular process controlling balance (GO:0050885)2.40121313
132positive regulation of heat generation (GO:0031652)2.40005098
133positive regulation of potassium ion transmembrane transport (GO:1901381)2.39995629
134regulation of vesicle fusion (GO:0031338)2.39691959
135membrane depolarization during action potential (GO:0086010)2.39413808
136synaptic vesicle endocytosis (GO:0048488)2.38983963
137positive regulation of dendritic spine development (GO:0060999)2.38795874
138long-term memory (GO:0007616)2.37433377
139negative regulation of interleukin-12 production (GO:0032695)2.37365176
140regulation of fever generation (GO:0031620)2.36054461
141regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35187217
142positive regulation of synapse maturation (GO:0090129)2.34429353
143positive regulation of Rap GTPase activity (GO:0032854)2.32939068
144regulation of T-helper 2 cell differentiation (GO:0045628)2.32831738
145regulation of vitamin D biosynthetic process (GO:0060556)2.31435213
146acidic amino acid transport (GO:0015800)2.28233820
147glycolipid catabolic process (GO:0019377)2.27256447
148response to nerve growth factor (GO:1990089)2.25679121
149cellular response to nerve growth factor stimulus (GO:1990090)2.25679121
150regulation of Rap GTPase activity (GO:0032317)2.25325195
151detection of calcium ion (GO:0005513)2.22445967
152response to acidic pH (GO:0010447)2.20057943
153cell communication involved in cardiac conduction (GO:0086065)2.19013404
154negative regulation of inclusion body assembly (GO:0090084)2.17543801
155regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.16997708
156regulation of neurotransmitter levels (GO:0001505)2.16949159
157regulation of postsynaptic membrane potential (GO:0060078)2.15909172
158neuromuscular process (GO:0050905)2.15818577
159positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.15193225
160barbed-end actin filament capping (GO:0051016)2.14980874
161alanine transport (GO:0032328)2.13128901
162L-glutamate transport (GO:0015813)2.12439075
163actin filament capping (GO:0051693)2.11551853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.90457988
2GBX2_23144817_ChIP-Seq_PC3_Human3.46228201
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80495749
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79707906
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60701557
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45927355
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45927355
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34956017
9* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34509254
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31400161
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31394976
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27221207
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.24312284
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21273131
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.18775308
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.07448574
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05322540
18DROSHA_22980978_ChIP-Seq_HELA_Human2.02714521
19RNF2_27304074_Chip-Seq_ESCs_Mouse1.97463791
20* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92988829
21REST_21632747_ChIP-Seq_MESCs_Mouse1.92723057
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90251727
23TAF15_26573619_Chip-Seq_HEK293_Human1.89261070
24RARB_27405468_Chip-Seq_BRAIN_Mouse1.78389531
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73568790
26* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67481349
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67322330
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67006208
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.65516348
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62438825
31AR_21572438_ChIP-Seq_LNCaP_Human1.60468367
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59034988
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.56230401
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55257856
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54626784
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.48709179
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48455944
38KDM2B_26808549_Chip-Seq_K562_Human1.46228470
39SMAD4_21799915_ChIP-Seq_A2780_Human1.45739850
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45432888
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43452218
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41763492
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.40018614
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.39604328
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39025985
46VDR_22108803_ChIP-Seq_LS180_Human1.36048975
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34835549
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.34569614
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30139417
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.29748411
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29674070
52* STAT3_23295773_ChIP-Seq_U87_Human1.29562052
53P300_19829295_ChIP-Seq_ESCs_Human1.29458654
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28036288
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26929004
56* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26597378
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25826091
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24873500
59IGF1R_20145208_ChIP-Seq_DFB_Human1.24735367
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24492620
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23210084
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.23164825
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23073344
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23050786
65VDR_24787735_ChIP-Seq_THP-1_Human1.19621981
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19312035
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19297326
68ER_23166858_ChIP-Seq_MCF-7_Human1.18964472
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17519610
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16618618
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15316262
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.14905945
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.13958842
74SOX2_21211035_ChIP-Seq_LN229_Gbm1.13583965
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13576453
76ZNF274_21170338_ChIP-Seq_K562_Hela1.10605600
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.09672872
78* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09482914
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08481828
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.08077999
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07645343
82DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07211594
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06582889
84RNF2_27304074_Chip-Seq_NSC_Mouse1.05835339
85* TCF4_23295773_ChIP-Seq_U87_Human1.05789355
86ARNT_22903824_ChIP-Seq_MCF-7_Human1.05229318
87AHR_22903824_ChIP-Seq_MCF-7_Human1.04803077
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04456159
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03756843
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02625835
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01687482
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00972418
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00972418
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.00474719
95PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00169436
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00026360
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99841404
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99815894
99WT1_19549856_ChIP-ChIP_CCG9911_Human0.98646661
100RING1B_27294783_Chip-Seq_NPCs_Mouse0.98137196
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97466569
102AR_25329375_ChIP-Seq_VCAP_Human0.97293884
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97099393
104* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96961500
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96775183
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96542839
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.96041941
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95929426
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.95362235
110NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94234185
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.93961310
112TRIM28_21343339_ChIP-Seq_HEK293_Human0.93610421
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93474938
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.93369853
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93125540
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92831727
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91912296
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91888594
119EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91825884
120AR_19668381_ChIP-Seq_PC3_Human0.91100697
121RUNX2_22187159_ChIP-Seq_PCA_Human0.90682690
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90350427
123SPI1_23127762_ChIP-Seq_K562_Human0.90107611
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.89685466
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89351021
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89115137
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88861797
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.88318515
129FUS_26573619_Chip-Seq_HEK293_Human0.88190094
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88119242
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88119242
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87761124
133ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86886370
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86462366
135LXR_22292898_ChIP-Seq_THP-1_Human0.85177129
136KDM2B_26808549_Chip-Seq_REH_Human0.84313753
137ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83040729
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.82920469
139MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81086510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia4.10370111
2MP0003880_abnormal_central_pattern4.04986484
3MP0004859_abnormal_synaptic_plasticity3.74038248
4MP0003303_peritoneal_inflammation3.52008332
5MP0000920_abnormal_myelination3.31130401
6MP0003635_abnormal_synaptic_transmissio2.84566694
7MP0002272_abnormal_nervous_system2.79436238
8MP0005058_abnormal_lysosome_morphology2.73434413
9MP0004510_myositis2.71102977
10MP0002734_abnormal_mechanical_nocicepti2.63944334
11MP0002064_seizures2.57854758
12MP0009046_muscle_twitch2.56519825
13MP0001486_abnormal_startle_reflex2.39692548
14MP0003329_amyloid_beta_deposits2.38014277
15MP0001968_abnormal_touch/_nociception2.35177153
16MP0009745_abnormal_behavioral_response2.31494450
17MP0003172_abnormal_lysosome_physiology2.28513534
18MP0005423_abnormal_somatic_nervous2.23903634
19MP0002735_abnormal_chemical_nociception2.23446076
20MP0006082_CNS_inflammation2.17332509
21MP0005167_abnormal_blood-brain_barrier2.15189924
22MP0003075_altered_response_to2.11538084
23MP0002063_abnormal_learning/memory/cond2.10919353
24MP0009840_abnormal_foam_cell2.00919721
25MP0002572_abnormal_emotion/affect_behav1.96120012
26MP0001970_abnormal_pain_threshold1.95055397
27MP0002736_abnormal_nociception_after1.93755310
28MP0002733_abnormal_thermal_nociception1.92675981
29MP0000778_abnormal_nervous_system1.92493708
30MP0004885_abnormal_endolymph1.91364971
31MP0001529_abnormal_vocalization1.90627750
32MP0004043_abnormal_pH_regulation1.88135992
33MP0004142_abnormal_muscle_tone1.87391890
34MP0000955_abnormal_spinal_cord1.80514989
35MP0003634_abnormal_glial_cell1.80116050
36MP0004742_abnormal_vestibular_system1.77093556
37MP0002067_abnormal_sensory_capabilities1.74281257
38MP0008569_lethality_at_weaning1.72811001
39MP0003950_abnormal_plasma_membrane1.71069766
40MP0000569_abnormal_digit_pigmentation1.68861083
41MP0001905_abnormal_dopamine_level1.66177723
42MP0002229_neurodegeneration1.64810934
43MP0003300_gastrointestinal_ulcer1.64184408
44MP0006276_abnormal_autonomic_nervous1.61795447
45MP0001440_abnormal_grooming_behavior1.60012601
46MP0003690_abnormal_glial_cell1.59502645
47MP0001299_abnormal_eye_distance/1.57942216
48MP0000343_altered_response_to1.57731223
49MP0009780_abnormal_chondrocyte_physiolo1.56972107
50MP0005171_absent_coat_pigmentation1.55829741
51MP0000678_abnormal_parathyroid_gland1.53514900
52MP0002184_abnormal_innervation1.53000682
53MP0002882_abnormal_neuron_morphology1.52225011
54MP0001485_abnormal_pinna_reflex1.49966492
55MP0008004_abnormal_stomach_pH1.45939412
56MP0004858_abnormal_nervous_system1.44979055
57MP0005623_abnormal_meninges_morphology1.43682950
58MP0005386_behavior/neurological_phenoty1.41380719
59MP0004924_abnormal_behavior1.41380719
60MP0005166_decreased_susceptibility_to1.40004201
61MP0002066_abnormal_motor_capabilities/c1.39050396
62MP0002822_catalepsy1.38809998
63MP0001501_abnormal_sleep_pattern1.36756242
64MP0005410_abnormal_fertilization1.35614776
65MP0003724_increased_susceptibility_to1.34806747
66MP0003633_abnormal_nervous_system1.34322790
67MP0004811_abnormal_neuron_physiology1.33253305
68MP0004145_abnormal_muscle_electrophysio1.32910969
69MP0000462_abnormal_digestive_system1.30361708
70MP0003122_maternal_imprinting1.29677585
71MP0000013_abnormal_adipose_tissue1.29358325
72MP0003283_abnormal_digestive_organ1.28016955
73MP0003631_nervous_system_phenotype1.27443452
74MP0002998_abnormal_bone_remodeling1.24982904
75MP0005551_abnormal_eye_electrophysiolog1.23043217
76MP0003632_abnormal_nervous_system1.22933589
77MP0001348_abnormal_lacrimal_gland1.22307343
78MP0002557_abnormal_social/conspecific_i1.20212081
79MP0008874_decreased_physiological_sensi1.15979794
80MP0005645_abnormal_hypothalamus_physiol1.14168548
81MP0003436_decreased_susceptibility_to1.10379941
82MP0002752_abnormal_somatic_nervous1.08730353
83MP0002148_abnormal_hypersensitivity_rea1.07668993
84MP0001963_abnormal_hearing_physiology1.06148387
85MP0005535_abnormal_body_temperature1.04593352
86MP0002419_abnormal_innate_immunity1.02012791
87MP0005646_abnormal_pituitary_gland1.01345101
88MP0002909_abnormal_adrenal_gland1.01126700
89MP0001502_abnormal_circadian_rhythm1.00738482
90MP0005409_darkened_coat_color0.97945626
91MP0000604_amyloidosis0.96869128
92MP0002152_abnormal_brain_morphology0.96056652
93MP0000747_muscle_weakness0.95347390
94MP0003448_altered_tumor_morphology0.94505636
95MP0009785_altered_susceptibility_to0.93768880
96MP0010386_abnormal_urinary_bladder0.93226561
97MP0001984_abnormal_olfaction0.92431639
98MP0003091_abnormal_cell_migration0.91719891
99MP0002896_abnormal_bone_mineralization0.91557824
100MP0001533_abnormal_skeleton_physiology0.90858396
101MP0006072_abnormal_retinal_apoptosis0.90262035
102MP0002877_abnormal_melanocyte_morpholog0.90168264
103MP0003191_abnormal_cellular_cholesterol0.88380832
104MP0001177_atelectasis0.87622245
105MP0004134_abnormal_chest_morphology0.85535861
106MP0009278_abnormal_bone_marrow0.84221097
107MP0005595_abnormal_vascular_smooth0.83469167
108MP0001986_abnormal_taste_sensitivity0.83117757
109MP0008438_abnormal_cutaneous_collagen0.82607640
110MP0000003_abnormal_adipose_tissue0.80893277
111MP0009764_decreased_sensitivity_to0.80843415
112MP0000751_myopathy0.80242720
113MP0003879_abnormal_hair_cell0.79964467
114MP0001958_emphysema0.76721456
115MP0006054_spinal_hemorrhage0.76496828
116MP0003183_abnormal_peptide_metabolism0.76144073
117MP0003195_calcinosis0.75431093
118MP0005310_abnormal_salivary_gland0.75354100
119MP0003279_aneurysm0.75276863
120MP0004085_abnormal_heartbeat0.74799680
121MP0001346_abnormal_lacrimal_gland0.74268833
122MP0003705_abnormal_hypodermis_morpholog0.73304505
123MP0002837_dystrophic_cardiac_calcinosis0.72794957
124MP0005000_abnormal_immune_tolerance0.71770701
125MP0000631_abnormal_neuroendocrine_gland0.71000829
126MP0003787_abnormal_imprinting0.70750328
127MP0004147_increased_porphyrin_level0.70734260
128MP0004036_abnormal_muscle_relaxation0.70677861
129MP0010234_abnormal_vibrissa_follicle0.69663805
130MP0002751_abnormal_autonomic_nervous0.68719740
131MP0002090_abnormal_vision0.68612745
132MP0002139_abnormal_hepatobiliary_system0.68182425
133MP0001664_abnormal_digestion0.67917010
134MP0003045_fibrosis0.67686802
135MP0005253_abnormal_eye_physiology0.67187677
136MP0003136_yellow_coat_color0.65954837
137MP0002069_abnormal_eating/drinking_beha0.65292284
138MP0000534_abnormal_ureter_morphology0.64750582
139MP0000026_abnormal_inner_ear0.64364336
140MP0002971_abnormal_brown_adipose0.64303941
141MP0003137_abnormal_impulse_conducting0.63650327
142MP0001943_abnormal_respiration0.63308096
143MP0001188_hyperpigmentation0.62995241
144MP0005025_abnormal_response_to0.62149464
145MP0004484_altered_response_of0.61869852
146MP0008260_abnormal_autophagy0.61586448
147MP0001765_abnormal_ion_homeostasis0.58733998

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.98036718
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.98036718
3Myokymia (HP:0002411)4.95735660
4Neurofibrillary tangles (HP:0002185)4.77114991
5Mutism (HP:0002300)4.65317572
6Abnormality of liposaccharide metabolism (HP:0010968)4.64224017
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.64224017
8Abnormality of glycolipid metabolism (HP:0010969)4.64224017
9Supranuclear gaze palsy (HP:0000605)4.41575899
10Abnormality of the corticospinal tract (HP:0002492)4.23974475
11Insidious onset (HP:0003587)4.12321190
12Termporal pattern (HP:0011008)4.12321190
13Focal motor seizures (HP:0011153)3.87388629
14Ankle clonus (HP:0011448)3.82039839
15Peripheral hypomyelination (HP:0007182)3.72699176
16Cerebral inclusion bodies (HP:0100314)3.65132293
17Pheochromocytoma (HP:0002666)3.61324964
18Action tremor (HP:0002345)3.56474457
19Onion bulb formation (HP:0003383)3.56448038
20Spastic gait (HP:0002064)3.55670726
21Disinhibition (HP:0000734)3.43001165
22Apathy (HP:0000741)3.33856979
23Atonic seizures (HP:0010819)3.29873886
24Increased cerebral lipofuscin (HP:0011813)3.21889269
25Vacuolated lymphocytes (HP:0001922)3.18752933
26Dysmetria (HP:0001310)3.17383477
27Focal seizures (HP:0007359)3.16530739
28Dysostosis multiplex (HP:0000943)3.15440152
29Neuroendocrine neoplasm (HP:0100634)3.08852149
30Diminished motivation (HP:0000745)3.06577299
31Abnormality of binocular vision (HP:0011514)3.02625314
32Diplopia (HP:0000651)3.02625314
33Scanning speech (HP:0002168)3.00336037
34Segmental peripheral demyelination/remyelination (HP:0003481)2.96662208
35Ulnar claw (HP:0001178)2.86689359
36Sensory axonal neuropathy (HP:0003390)2.85309244
37Loss of speech (HP:0002371)2.83158613
38Retinal dysplasia (HP:0007973)2.82979697
39Epileptic encephalopathy (HP:0200134)2.80463075
40Intention tremor (HP:0002080)2.79612685
41Systemic lupus erythematosus (HP:0002725)2.76534749
42Inappropriate behavior (HP:0000719)2.74389111
43Progressive cerebellar ataxia (HP:0002073)2.72558557
44Cerebral hypomyelination (HP:0006808)2.71092306
45Nuclear cataract (HP:0100018)2.68081392
46Abnormal auditory evoked potentials (HP:0006958)2.64948282
47Alacrima (HP:0000522)2.55406330
48Hammertoe (HP:0001765)2.54801719
49Lower limb muscle weakness (HP:0007340)2.54469266
50Foot dorsiflexor weakness (HP:0009027)2.53868196
51Abnormality of polysaccharide metabolism (HP:0011012)2.49772613
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49772613
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49772613
54Urinary glycosaminoglycan excretion (HP:0003541)2.46036652
55Mucopolysacchariduria (HP:0008155)2.46036652
56Abnormality of macrophages (HP:0004311)2.45566817
57Decreased motor nerve conduction velocity (HP:0003431)2.44922763
58Hemiplegia (HP:0002301)2.43992557
59Axonal loss (HP:0003447)2.42966618
60Truncal ataxia (HP:0002078)2.41364460
61Urinary urgency (HP:0000012)2.40754688
62Megalencephaly (HP:0001355)2.39711808
63Amyloidosis (HP:0011034)2.38422002
64Dementia (HP:0000726)2.37831740
65Absence seizures (HP:0002121)2.34757453
66Abnormality of the foot musculature (HP:0001436)2.34071315
67Visual hallucinations (HP:0002367)2.33304904
68Dialeptic seizures (HP:0011146)2.30169035
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.29265149
70Rapidly progressive (HP:0003678)2.27978943
71Abnormality of the periventricular white matter (HP:0002518)2.27516901
72Slow saccadic eye movements (HP:0000514)2.27385529
73Clonus (HP:0002169)2.24584845
74Abnormality of calcium-phosphate metabolism (HP:0100530)2.23661106
75Tetraplegia (HP:0002445)2.22427883
76Urinary bladder sphincter dysfunction (HP:0002839)2.21478012
77Hyperphosphatemia (HP:0002905)2.18054758
78Aplasia involving bones of the extremities (HP:0009825)2.16951238
79Aplasia involving bones of the upper limbs (HP:0009823)2.16951238
80Aplasia of the phalanges of the hand (HP:0009802)2.16951238
81Steppage gait (HP:0003376)2.15737831
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14181172
83Generalized tonic-clonic seizures (HP:0002069)2.13314090
84Dysdiadochokinesis (HP:0002075)2.12662708
85Eczematoid dermatitis (HP:0000976)2.11800794
86Hematochezia (HP:0002573)2.11130484
87Tetany (HP:0001281)2.10954897
88Thickened helices (HP:0000391)2.10925047
89Akinesia (HP:0002304)2.10466976
90Distal sensory impairment (HP:0002936)2.10127042
91Anteriorly placed anus (HP:0001545)2.10082659
92Memory impairment (HP:0002354)2.09537867
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08589140
94Febrile seizures (HP:0002373)2.07814249
95Obstructive sleep apnea (HP:0002870)2.07438686
96Hyperparathyroidism (HP:0000843)2.06906406
97Recurrent bacterial skin infections (HP:0005406)2.06325663
98Anxiety (HP:0000739)2.05984819
99Increased circulating renin level (HP:0000848)2.04827258
100Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.04628883
101Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03462911
102Retinal atrophy (HP:0001105)2.03277927
103Polyphagia (HP:0002591)2.02093214
104Limb dystonia (HP:0002451)2.00671734
105Rigidity (HP:0002063)1.99860809
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98298155
107Decreased lacrimation (HP:0000633)1.97889499
108Bradykinesia (HP:0002067)1.97873872
109Cerebral aneurysm (HP:0004944)1.96902272
110Gaze-evoked nystagmus (HP:0000640)1.95768582
111Focal dystonia (HP:0004373)1.94202347
112Papilledema (HP:0001085)1.93968089
113Depression (HP:0000716)1.93708943
114Agnosia (HP:0010524)1.93392901
115Bundle branch block (HP:0011710)1.93360860
116CNS hypomyelination (HP:0003429)1.91385924
117Asymmetric septal hypertrophy (HP:0001670)1.89445000
118Autoamputation (HP:0001218)1.89351898
119Morphological abnormality of the pyramidal tract (HP:0002062)1.87780300
120Impaired vibration sensation in the lower limbs (HP:0002166)1.86328062
121Ventricular fibrillation (HP:0001663)1.83903040
122Buphthalmos (HP:0000557)1.83818252
123Vaginal atresia (HP:0000148)1.83291648
124Postural tremor (HP:0002174)1.82710529
125Craniofacial dystonia (HP:0012179)1.82149136
126Glomerulonephritis (HP:0000099)1.81854753
127Parakeratosis (HP:0001036)1.80759039
128Genital tract atresia (HP:0001827)1.80239949
129Cerebral hemorrhage (HP:0001342)1.79218483
130Leukodystrophy (HP:0002415)1.78860324
131Recurrent abscess formation (HP:0002722)1.78782187
132Resting tremor (HP:0002322)1.78303046
133Abnormal eating behavior (HP:0100738)1.77052169
134Poor speech (HP:0002465)1.76684446
135Postural instability (HP:0002172)1.76071756
136Neuronal loss in central nervous system (HP:0002529)1.75946791
137Metabolic alkalosis (HP:0200114)1.75204208
138Urinary incontinence (HP:0000020)1.74751004
139Torticollis (HP:0000473)1.73887079
140Type II lissencephaly (HP:0007260)1.73578360
141Infantile muscular hypotonia (HP:0008947)1.73337203
142Agitation (HP:0000713)1.72307162
143Increased CSF protein (HP:0002922)1.72030133
144Hyporeflexia of lower limbs (HP:0002600)1.71935592
145Broad-based gait (HP:0002136)1.71801148
146Hemiparesis (HP:0001269)1.71504334
147Bradycardia (HP:0001662)1.71480491
148Split foot (HP:0001839)1.70233180
149Spontaneous hematomas (HP:0007420)1.70182173
150Stereotypic behavior (HP:0000733)1.69811311
151Metaphyseal irregularity (HP:0003025)1.69475814
152Slow progression (HP:0003677)1.69214725
153EEG with generalized epileptiform discharges (HP:0011198)1.69066618
154Abnormality of saccadic eye movements (HP:0000570)1.68335527
155Spastic tetraparesis (HP:0001285)1.68142909
156Personality changes (HP:0000751)1.66869104
157Epileptiform EEG discharges (HP:0011182)1.66804399
158Clumsiness (HP:0002312)1.66437455
159Paraplegia (HP:0010550)1.66395584
160Stridor (HP:0010307)1.66353518
161Spastic paraplegia (HP:0001258)1.66151618
162Progressive inability to walk (HP:0002505)1.63955816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.57458683
2OXSR13.10014753
3RIPK12.98388728
4NTRK12.65682430
5NTRK32.61704375
6WNK12.40013853
7WNK42.36634389
8LIMK12.31241632
9MAP3K92.08804661
10PAK62.02410103
11RIPK42.01942836
12MAPKAPK52.01647033
13UHMK11.98975627
14BCR1.92653411
15MARK11.92054839
16MINK11.88775969
17CDK191.87640164
18IRAK31.83595168
19EPHB11.83592996
20PNCK1.79100577
21EPHA41.70702600
22MAP3K41.70488991
23PKN11.68605960
24PRKD31.66048562
25PRPF4B1.63798155
26CASK1.55011069
27KSR21.54425300
28MOS1.50811800
29GRK71.49750717
30SGK4941.48178178
31SGK2231.48178178
32CAMK2B1.42746253
33MET1.37319988
34FGFR21.35443425
35PAK31.34816842
36CDK51.29245842
37ARAF1.28353410
38TGFBR21.26906707
39CAMK2D1.26813074
40NEK61.23898342
41CSNK1A1L1.22612684
42MAP3K21.22007806
43CSNK1G31.20327364
44ROCK21.19357633
45ACVR1B1.18770469
46LMTK21.17801675
47PHKG11.17257524
48PHKG21.17257524
49TESK21.16840858
50CSNK1G21.16091273
51MAP2K71.15620714
52NTRK21.13430093
53SIK21.09222977
54BLK1.08782494
55CDK141.08746973
56TNIK1.07595287
57BMPR21.06553258
58MAP3K111.04946682
59CAMK2A1.04537563
60CAMK2G1.03017298
61CDK150.97832684
62PDGFRA0.96780911
63CDK180.95909184
64MAP3K140.95087779
65MATK0.93840539
66ICK0.92322825
67MARK20.91832719
68STK380.91411833
69MAPK130.90173671
70CAMK10.89803305
71SGK30.89756634
72SGK20.89434768
73CAMK1D0.87399468
74PBK0.87155435
75JAK10.86759409
76CDK11A0.85548277
77LATS20.85297213
78PRKCH0.83627015
79PRKCE0.81163477
80MAP3K30.80727309
81FES0.80488963
82CSNK1G10.79904668
83DDR20.79865303
84TYRO30.76743864
85GRK50.76022037
86PLK20.75823931
87TAOK10.74986491
88TAOK20.74313845
89MAPK150.73638411
90MAPK120.72594488
91JAK20.72418091
92RET0.71523163
93MAP2K40.70724297
94PRKD10.69733025
95CSK0.69280595
96CAMKK20.67281766
97PDPK10.66902055
98TYK20.66162039
99CAMK40.65991132
100CAMKK10.65822598
101FGR0.65326051
102PRKCG0.63844910
103ALK0.62653189
104TESK10.62428979
105DAPK20.60442209
106CDC42BPA0.58798052
107FER0.56129874
108STK110.55475780
109DYRK1A0.54668363
110DYRK20.54469075
111MAP3K130.54263368
112PINK10.53551381
113MAP3K10.53321971
114CAMK1G0.52610306
115HIPK20.52067228
116DAPK10.51609394
117PRKG10.49982830
118IRAK20.49547349
119BMPR1B0.49272469
120RPS6KA20.47872819
121FYN0.47546063
122INSRR0.47021575
123ABL20.46791103
124PDGFRB0.46584766
125MAPK100.46333710
126PTK2B0.44956055
127MUSK0.44036507
128MAPK70.43798495
129PRKCZ0.42804267
130PRKACB0.42760426
131BRAF0.42674635
132PRKCQ0.41888415
133CLK10.41552358
134KSR10.41361392
135PRKG20.40732692
136PTK20.40599471
137ROCK10.40498351
138MAPK40.39328261
139PKN20.38416524
140SGK10.37480680
141WNK30.36891300
142PDK10.36799242

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87586013
2Synaptic vesicle cycle_Homo sapiens_hsa047212.56080705
3GABAergic synapse_Homo sapiens_hsa047272.27155752
4Nicotine addiction_Homo sapiens_hsa050332.16392756
5Steroid biosynthesis_Homo sapiens_hsa001002.04145301
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01340061
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00863281
8Glutamatergic synapse_Homo sapiens_hsa047242.00633846
9Circadian entrainment_Homo sapiens_hsa047131.99324292
10Fatty acid elongation_Homo sapiens_hsa000621.99286138
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93552217
12Morphine addiction_Homo sapiens_hsa050321.87971454
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86166641
14Insulin secretion_Homo sapiens_hsa049111.80845575
15Olfactory transduction_Homo sapiens_hsa047401.77585936
16Dopaminergic synapse_Homo sapiens_hsa047281.72360486
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71405655
18Serotonergic synapse_Homo sapiens_hsa047261.70893061
19Ether lipid metabolism_Homo sapiens_hsa005651.69793281
20Amphetamine addiction_Homo sapiens_hsa050311.66454847
21Long-term potentiation_Homo sapiens_hsa047201.60029860
22Taste transduction_Homo sapiens_hsa047421.59085151
23Salivary secretion_Homo sapiens_hsa049701.58763873
24Cocaine addiction_Homo sapiens_hsa050301.57858867
25Long-term depression_Homo sapiens_hsa047301.55989701
26Vibrio cholerae infection_Homo sapiens_hsa051101.53567992
27Other glycan degradation_Homo sapiens_hsa005111.52876624
28Cholinergic synapse_Homo sapiens_hsa047251.51851652
29Axon guidance_Homo sapiens_hsa043601.51322220
30Collecting duct acid secretion_Homo sapiens_hsa049661.48616077
31Gastric acid secretion_Homo sapiens_hsa049711.45881764
32Osteoclast differentiation_Homo sapiens_hsa043801.43075155
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33022468
34Rheumatoid arthritis_Homo sapiens_hsa053231.32751891
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32047299
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28250775
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25871966
38Renin secretion_Homo sapiens_hsa049241.24425271
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23537901
40Gap junction_Homo sapiens_hsa045401.20199347
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19077243
42Pertussis_Homo sapiens_hsa051331.17734887
43Tuberculosis_Homo sapiens_hsa051521.16664825
44Sulfur metabolism_Homo sapiens_hsa009201.14042025
45Cardiac muscle contraction_Homo sapiens_hsa042601.13414872
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12362385
47Oxidative phosphorylation_Homo sapiens_hsa001901.10477135
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07355537
49Sphingolipid metabolism_Homo sapiens_hsa006001.06527761
50Salmonella infection_Homo sapiens_hsa051321.05856512
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.05787326
52Nitrogen metabolism_Homo sapiens_hsa009101.04920437
53Vascular smooth muscle contraction_Homo sapiens_hsa042701.04913467
54Dorso-ventral axis formation_Homo sapiens_hsa043201.02853913
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02580421
56Oxytocin signaling pathway_Homo sapiens_hsa049210.98871334
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98838657
58GnRH signaling pathway_Homo sapiens_hsa049120.98776121
59Leishmaniasis_Homo sapiens_hsa051400.98752112
60Staphylococcus aureus infection_Homo sapiens_hsa051500.97537080
61Alzheimers disease_Homo sapiens_hsa050100.96806281
62Pancreatic secretion_Homo sapiens_hsa049720.94448792
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93810336
64Phototransduction_Homo sapiens_hsa047440.93591351
65Amoebiasis_Homo sapiens_hsa051460.93497406
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91063182
67Calcium signaling pathway_Homo sapiens_hsa040200.90833268
68ErbB signaling pathway_Homo sapiens_hsa040120.90116375
69cAMP signaling pathway_Homo sapiens_hsa040240.89618319
70Protein export_Homo sapiens_hsa030600.87404304
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87331487
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87041412
73Mineral absorption_Homo sapiens_hsa049780.86615331
74TNF signaling pathway_Homo sapiens_hsa046680.86128556
75Chemokine signaling pathway_Homo sapiens_hsa040620.86091669
76Type II diabetes mellitus_Homo sapiens_hsa049300.85732237
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85367083
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85220020
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.83602951
80Malaria_Homo sapiens_hsa051440.82846980
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.82498561
82African trypanosomiasis_Homo sapiens_hsa051430.82191217
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81501258
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.80887858
85Parkinsons disease_Homo sapiens_hsa050120.80864593
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80066457
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.79319497
88Melanogenesis_Homo sapiens_hsa049160.79047971
89VEGF signaling pathway_Homo sapiens_hsa043700.78941764
90Estrogen signaling pathway_Homo sapiens_hsa049150.77239770
91Renal cell carcinoma_Homo sapiens_hsa052110.76995545
92Endocytosis_Homo sapiens_hsa041440.76886141
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75890407
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74193341
95Ras signaling pathway_Homo sapiens_hsa040140.73683376
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73327511
97Vitamin B6 metabolism_Homo sapiens_hsa007500.73245593
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72907065
99Thyroid hormone synthesis_Homo sapiens_hsa049180.72573380
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72366760
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70759801
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70273620
103Hedgehog signaling pathway_Homo sapiens_hsa043400.69019836
104* Tight junction_Homo sapiens_hsa045300.68976129
105Butanoate metabolism_Homo sapiens_hsa006500.68125523
106Dilated cardiomyopathy_Homo sapiens_hsa054140.68003491
107Legionellosis_Homo sapiens_hsa051340.66980268
108Protein digestion and absorption_Homo sapiens_hsa049740.66818760
109Ovarian steroidogenesis_Homo sapiens_hsa049130.64923372
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.64055216
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61584938
112Prolactin signaling pathway_Homo sapiens_hsa049170.59939348
113Fatty acid biosynthesis_Homo sapiens_hsa000610.59669844
114Toxoplasmosis_Homo sapiens_hsa051450.58752473
115Choline metabolism in cancer_Homo sapiens_hsa052310.57650620
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57539063
117Linoleic acid metabolism_Homo sapiens_hsa005910.57393901
118PPAR signaling pathway_Homo sapiens_hsa033200.55400629
119MAPK signaling pathway_Homo sapiens_hsa040100.55361836
120Type I diabetes mellitus_Homo sapiens_hsa049400.54777772
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.54529381
122Glioma_Homo sapiens_hsa052140.54127231
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52527103
124Bile secretion_Homo sapiens_hsa049760.52342299
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51942771
126Histidine metabolism_Homo sapiens_hsa003400.51525926
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50908687
128B cell receptor signaling pathway_Homo sapiens_hsa046620.50849443
129Platelet activation_Homo sapiens_hsa046110.50773568
130Alcoholism_Homo sapiens_hsa050340.50461975
131Prion diseases_Homo sapiens_hsa050200.48740988
132HIF-1 signaling pathway_Homo sapiens_hsa040660.47334890
133Phagosome_Homo sapiens_hsa041450.46745707
134Inositol phosphate metabolism_Homo sapiens_hsa005620.46731837
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44411002
136Rap1 signaling pathway_Homo sapiens_hsa040150.43197517
137Lysosome_Homo sapiens_hsa041420.43130982
138Wnt signaling pathway_Homo sapiens_hsa043100.42087829

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