EPB41L5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.57164247
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.57164247
3aromatic amino acid family catabolic process (GO:0009074)4.42890836
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34404342
5L-phenylalanine metabolic process (GO:0006558)4.34404342
6glyoxylate metabolic process (GO:0046487)4.33896381
7tryptophan catabolic process (GO:0006569)4.29678368
8indole-containing compound catabolic process (GO:0042436)4.29678368
9indolalkylamine catabolic process (GO:0046218)4.29678368
10serine family amino acid catabolic process (GO:0009071)4.23702103
11homocysteine metabolic process (GO:0050667)4.15646544
12tryptophan metabolic process (GO:0006568)4.10131915
13cysteine metabolic process (GO:0006534)3.74104165
14regulation of meiosis I (GO:0060631)3.70789679
15kynurenine metabolic process (GO:0070189)3.66479481
16lysine metabolic process (GO:0006553)3.45745137
17lysine catabolic process (GO:0006554)3.45745137
18bile acid biosynthetic process (GO:0006699)3.42437509
19sulfur amino acid catabolic process (GO:0000098)3.42393875
20urea cycle (GO:0000050)3.42070715
21urea metabolic process (GO:0019627)3.42070715
22glycine metabolic process (GO:0006544)3.41510980
23serine family amino acid metabolic process (GO:0009069)3.34587436
24amino-acid betaine metabolic process (GO:0006577)3.30207714
25cellular biogenic amine catabolic process (GO:0042402)3.25749114
26amine catabolic process (GO:0009310)3.25749114
27aromatic amino acid family metabolic process (GO:0009072)3.24852658
28serine family amino acid biosynthetic process (GO:0009070)3.24221805
29urate metabolic process (GO:0046415)3.20632511
30high-density lipoprotein particle remodeling (GO:0034375)3.20568792
31glomerulus development (GO:0032835)3.20431006
32response to nitrosative stress (GO:0051409)3.18498175
33alpha-amino acid catabolic process (GO:1901606)3.17439809
34triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09392771
35limb bud formation (GO:0060174)3.08956790
36drug catabolic process (GO:0042737)3.08359967
37nitrogen cycle metabolic process (GO:0071941)3.06883210
38glomerular basement membrane development (GO:0032836)3.04075989
39regulation of bile acid biosynthetic process (GO:0070857)3.03583152
40regulation of fibrinolysis (GO:0051917)3.03234716
41reverse cholesterol transport (GO:0043691)2.98367886
42indolalkylamine metabolic process (GO:0006586)2.97672332
43regulation of protein activation cascade (GO:2000257)2.97173023
44tyrosine metabolic process (GO:0006570)2.95019385
45bile acid metabolic process (GO:0008206)2.93606678
46negative regulation of fibrinolysis (GO:0051918)2.92252853
47cellular amino acid catabolic process (GO:0009063)2.91201125
48* paraxial mesoderm development (GO:0048339)2.91182620
49alpha-linolenic acid metabolic process (GO:0036109)2.89269410
50piRNA metabolic process (GO:0034587)2.88906436
51imidazole-containing compound metabolic process (GO:0052803)2.82865213
52fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.80798510
53benzene-containing compound metabolic process (GO:0042537)2.79359660
54peptidyl-glutamic acid carboxylation (GO:0017187)2.79314861
55protein carboxylation (GO:0018214)2.79314861
56presynaptic membrane assembly (GO:0097105)2.76459163
57drug transmembrane transport (GO:0006855)2.76162512
58embryonic retina morphogenesis in camera-type eye (GO:0060059)2.76065854
59regulation of complement activation (GO:0030449)2.75904214
60pyrimidine nucleobase catabolic process (GO:0006208)2.75486013
61complement activation, alternative pathway (GO:0006957)2.74371432
62positive regulation of action potential (GO:0045760)2.73101081
63regulation of cholesterol esterification (GO:0010872)2.70781712
64acylglycerol homeostasis (GO:0055090)2.70630889
65triglyceride homeostasis (GO:0070328)2.70630889
66aminoglycoside antibiotic metabolic process (GO:0030647)2.69786711
67negative regulation of sterol transport (GO:0032372)2.68348032
68negative regulation of cholesterol transport (GO:0032375)2.68348032
69genitalia morphogenesis (GO:0035112)2.66997592
70regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.65960706
71cellular modified amino acid catabolic process (GO:0042219)2.61900027
72gap junction assembly (GO:0016264)2.61646021
73branched-chain amino acid catabolic process (GO:0009083)2.61014196
74aldehyde catabolic process (GO:0046185)2.58917610
75arginine metabolic process (GO:0006525)2.58755586
76negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.57253353
77synapsis (GO:0007129)2.57132432
78protein-chromophore linkage (GO:0018298)2.56604156
79plasma lipoprotein particle remodeling (GO:0034369)2.56599887
80protein-lipid complex remodeling (GO:0034368)2.56599887
81macromolecular complex remodeling (GO:0034367)2.56599887
82cellular glucuronidation (GO:0052695)2.54057373
83exogenous drug catabolic process (GO:0042738)2.53517509
84DNA methylation involved in gamete generation (GO:0043046)2.52885265
85drug metabolic process (GO:0017144)2.49938302
86carboxylic acid catabolic process (GO:0046395)2.48404677
87organic acid catabolic process (GO:0016054)2.48404677
88mitotic sister chromatid cohesion (GO:0007064)2.47381582
89xenobiotic catabolic process (GO:0042178)2.46157168
90S-adenosylmethionine metabolic process (GO:0046500)2.45790810
91RNA localization (GO:0006403)2.43623009
92gastrulation with mouth forming second (GO:0001702)2.43535281
93bile acid and bile salt transport (GO:0015721)2.39187023
94axonal fasciculation (GO:0007413)2.39050455
95presynaptic membrane organization (GO:0097090)2.37799647
96drug transport (GO:0015893)2.37629363
97glomerular epithelial cell development (GO:0072310)2.37425247
98intraciliary transport (GO:0042073)2.36944010
99glomerular visceral epithelial cell development (GO:0072015)2.36056515
100linoleic acid metabolic process (GO:0043651)2.35543767
101polyketide metabolic process (GO:0030638)2.34611646
102doxorubicin metabolic process (GO:0044598)2.34611646
103daunorubicin metabolic process (GO:0044597)2.34611646
104midgut development (GO:0007494)2.33687103
105regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33507727
106notochord development (GO:0030903)2.33275390
107tachykinin receptor signaling pathway (GO:0007217)2.32473902
108ethanol oxidation (GO:0006069)2.32121573
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.31263029
110very-low-density lipoprotein particle assembly (GO:0034379)2.30996497
111behavioral response to ethanol (GO:0048149)2.30789090
112apical protein localization (GO:0045176)2.30635273
113* embryonic foregut morphogenesis (GO:0048617)2.30455647
114positive regulation of meiosis (GO:0045836)2.30285116
115negative regulation of fatty acid biosynthetic process (GO:0045717)2.30010175
116nucleobase catabolic process (GO:0046113)2.29103128
117L-serine metabolic process (GO:0006563)2.28993000
118renal absorption (GO:0070293)2.27971118
119male meiosis (GO:0007140)2.27847528
120cellular ketone body metabolic process (GO:0046950)2.27231682
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.26728617
122regulation of growth hormone secretion (GO:0060123)2.25287708
123phospholipid efflux (GO:0033700)2.25172011
124positive regulation of male gonad development (GO:2000020)2.24908409
125photoreceptor cell maintenance (GO:0045494)2.24744724
126branched-chain amino acid metabolic process (GO:0009081)2.24587733
127establishment of nucleus localization (GO:0040023)2.23827935
128regulation of centriole replication (GO:0046599)2.23352337
129appendage development (GO:0048736)2.22240401
130limb development (GO:0060173)2.22240401
131hippo signaling (GO:0035329)2.21439571
132chromosome organization involved in meiosis (GO:0070192)2.19682703
133nonmotile primary cilium assembly (GO:0035058)2.19406556
134positive regulation of meiotic cell cycle (GO:0051446)2.19004028
135sex differentiation (GO:0007548)2.18794161
136protein localization to cilium (GO:0061512)2.17414007
137ectodermal placode formation (GO:0060788)2.16561498
138resolution of meiotic recombination intermediates (GO:0000712)2.16166262
139inner ear receptor cell development (GO:0060119)2.15690597
140* somite rostral/caudal axis specification (GO:0032525)2.13623257
141dorsal/ventral axis specification (GO:0009950)2.12877900
142body morphogenesis (GO:0010171)2.09320003
143retina vasculature morphogenesis in camera-type eye (GO:0061299)2.08519579
144neurotransmitter-gated ion channel clustering (GO:0072578)2.08446100
145pre-miRNA processing (GO:0031054)2.07291797
146regulation of gene silencing by RNA (GO:0060966)2.06655188
147regulation of posttranscriptional gene silencing (GO:0060147)2.06655188
148regulation of gene silencing by miRNA (GO:0060964)2.06655188
149regulation of cardioblast differentiation (GO:0051890)2.06504645
150olfactory bulb development (GO:0021772)2.06476460
151neuron recognition (GO:0008038)2.05875160
152sister chromatid cohesion (GO:0007062)2.05454701
153gene silencing by RNA (GO:0031047)2.04263644
154nuclear pore complex assembly (GO:0051292)2.00261337
155peptidyl-lysine dimethylation (GO:0018027)1.99912788
156microtubule anchoring (GO:0034453)1.99906682
157synaptonemal complex assembly (GO:0007130)1.99468276
158histone H3-K9 demethylation (GO:0033169)1.99338397
159neuronal stem cell maintenance (GO:0097150)1.98051321
160regulation of centrosome duplication (GO:0010824)1.97765925
161retinal ganglion cell axon guidance (GO:0031290)1.97563489
162cardiac right ventricle morphogenesis (GO:0003215)1.97436137
163positive regulation of catenin import into nucleus (GO:0035413)1.97123126
164mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)1.96529686
165nuclear pore organization (GO:0006999)1.96432369
166regulation of male gonad development (GO:2000018)1.96149240
167Sertoli cell development (GO:0060009)1.95331986
168negative regulation of lipase activity (GO:0060192)1.95282050
169oocyte development (GO:0048599)1.94939534
170morphogenesis of an epithelial sheet (GO:0002011)1.94355188
171ephrin receptor signaling pathway (GO:0048013)1.93903420
172nucleus localization (GO:0051647)1.92749098
173calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)1.89990209
174cell migration involved in gastrulation (GO:0042074)1.89822787
175layer formation in cerebral cortex (GO:0021819)1.89210103
176synaptonemal complex organization (GO:0070193)1.88910958
177otic vesicle formation (GO:0030916)1.88528053
178G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071991.87873877
179regulation of hippo signaling (GO:0035330)1.87495694
180artery development (GO:0060840)1.87026406
181male meiosis I (GO:0007141)1.86835078
182DNA double-strand break processing (GO:0000729)1.84702228
183chromatin remodeling at centromere (GO:0031055)1.84239684
184postsynaptic membrane organization (GO:0001941)1.84217980
185hair cell differentiation (GO:0035315)1.84077378
186regulation of centrosome cycle (GO:0046605)1.83948407
187asymmetric protein localization (GO:0008105)1.82994601
188sympathetic nervous system development (GO:0048485)1.82639443
189cerebral cortex development (GO:0021987)1.82492538
190kidney morphogenesis (GO:0060993)1.80307328
191* anterior/posterior axis specification (GO:0009948)1.79671186
192positive regulation of gastrulation (GO:2000543)1.79377999
193axon extension involved in axon guidance (GO:0048846)1.79363703
194neuron projection extension involved in neuron projection guidance (GO:1902284)1.79363703
195spinal cord development (GO:0021510)1.78800854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.93411898
2EGR1_23403033_ChIP-Seq_LIVER_Mouse4.42764453
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.26000324
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.61471239
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.35852240
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.35385196
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.30131823
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.24472664
9GBX2_23144817_ChIP-Seq_PC3_Human2.84708204
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76144208
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.71839534
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.60951351
13E2F7_22180533_ChIP-Seq_HELA_Human2.57431483
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.51762455
15EZH2_22144423_ChIP-Seq_EOC_Human2.50304672
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44541043
17IGF1R_20145208_ChIP-Seq_DFB_Human2.39527127
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39271161
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37310446
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.36415699
21AR_21909140_ChIP-Seq_LNCAP_Human2.30753778
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30329453
23FUS_26573619_Chip-Seq_HEK293_Human2.27055242
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21001778
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09896545
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.01548295
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98427829
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97844344
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97362892
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95220896
31TAF15_26573619_Chip-Seq_HEK293_Human1.95021391
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94177998
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89198806
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86676373
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84245994
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79910459
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79295305
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74974825
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.73480706
40* P300_19829295_ChIP-Seq_ESCs_Human1.72853410
41* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.67130804
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.65337590
43SMAD4_21799915_ChIP-Seq_A2780_Human1.64598185
44EWS_26573619_Chip-Seq_HEK293_Human1.62895521
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.61911743
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61630621
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.58277903
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.57657281
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.57657281
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.57657281
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.54829461
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54406493
53ZNF274_21170338_ChIP-Seq_K562_Hela1.53404645
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50328779
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49478747
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48208674
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.47669919
58STAT3_23295773_ChIP-Seq_U87_Human1.45556043
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44240989
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41168871
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40508367
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40479909
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39880638
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37848147
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36152726
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.34677760
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34199910
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33754362
69KAP1_22055183_ChIP-Seq_ESCs_Mouse1.31661263
70* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29555185
71AHR_22903824_ChIP-Seq_MCF-7_Human1.29199010
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25784039
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25647745
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.25456205
75AR_25329375_ChIP-Seq_VCAP_Human1.23662486
76VDR_22108803_ChIP-Seq_LS180_Human1.23555847
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22187166
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.21972301
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21482634
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20853083
81TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20718038
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20597488
83ER_23166858_ChIP-Seq_MCF-7_Human1.20283742
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20034043
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19984982
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.19871002
87* TCF4_23295773_ChIP-Seq_U87_Human1.19115435
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.19075554
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19048121
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18926974
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17655222
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17358301
93* CBP_20019798_ChIP-Seq_JUKART_Human1.17358301
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16846501
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16781682
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16762247
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14731734
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14731734
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.13510417
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.13165486
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.11741309
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11127609
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10710045
104BCAT_22108803_ChIP-Seq_LS180_Human1.09548772
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08378963
106CLOCK_20551151_ChIP-Seq_293T_Human1.08027368
107GATA4_25053715_ChIP-Seq_YYC3_Human1.06602457
108SOX9_26525672_Chip-Seq_HEART_Mouse1.05939951
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05191246
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04365283
111EZH2_27304074_Chip-Seq_ESCs_Mouse1.03965097
112TP53_18474530_ChIP-ChIP_U2OS_Human1.03946131
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02451239
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02084346
115SOX2_21211035_ChIP-Seq_LN229_Gbm1.01341952
116ISL1_27105846_Chip-Seq_CPCs_Mouse1.01338145
117HTT_18923047_ChIP-ChIP_STHdh_Human1.01123443
118* HNF4A_19822575_ChIP-Seq_HepG2_Human1.00909764
119SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00879328
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.00633915
121TCF4_22108803_ChIP-Seq_LS180_Human0.99212333
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97800551
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97505568
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.97419868
125* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97322302
126CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97058394
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96999559
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96696846
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96643999
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96381398
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.96083039
132E2F1_21310950_ChIP-Seq_MCF-7_Human0.95659961
133* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95565361
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95314352
135* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94484691
136IRF1_19129219_ChIP-ChIP_H3396_Human0.94393111
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.94376457
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.94333903
139NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93816512
140SMAD4_21741376_ChIP-Seq_HESCs_Human0.93761481
141* SRF_21415370_ChIP-Seq_HL-1_Mouse0.92978779
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92529106
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.92429516
144MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91961751
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.91919520
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91387968
147CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91297072
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91261913
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90398412
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90287336
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.90202824
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90027410
153RNF2_27304074_Chip-Seq_NSC_Mouse0.88285219
154STAT1_17558387_ChIP-Seq_HELA_Human0.88132939
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86855185
156SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85559756
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85427364
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.84593500
159RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82449977
160SOX2_16153702_ChIP-ChIP_HESCs_Human0.82123878
161ESR1_20079471_ChIP-ChIP_T-47D_Human0.81856278
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81579997
163ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81263740
164PIAS1_25552417_ChIP-Seq_VCAP_Human0.80450111
165* FOXA2_19822575_ChIP-Seq_HepG2_Human0.79876289
166RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79485071
167SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79404858
168YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78835093
169MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78751771
170PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78324508
171SOX2_27498859_Chip-Seq_STOMACH_Mouse0.77691556
172JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.77676635
173ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77159637
174* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75611123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.22780222
2MP0005360_urolithiasis3.96301329
3MP0005365_abnormal_bile_salt3.65502597
4MP0005085_abnormal_gallbladder_physiolo3.44883195
5MP0003011_delayed_dark_adaptation3.24666723
6MP0010030_abnormal_orbit_morphology2.85825152
7MP0000566_synostosis2.84146974
8MP0008875_abnormal_xenobiotic_pharmacok2.74541836
9MP0004019_abnormal_vitamin_homeostasis2.30499975
10MP0003252_abnormal_bile_duct2.28413174
11MP0003122_maternal_imprinting2.10315933
12MP0005332_abnormal_amino_acid1.94465246
13MP0005248_abnormal_Harderian_gland1.88634443
14MP0006292_abnormal_olfactory_placode1.83938001
15MP0003806_abnormal_nucleotide_metabolis1.81244120
16MP0003195_calcinosis1.79422247
17MP0003941_abnormal_skin_development1.79327222
18MP0003890_abnormal_embryonic-extraembry1.78997249
19MP0005551_abnormal_eye_electrophysiolog1.78307200
20MP0008057_abnormal_DNA_replication1.75604824
21MP0002138_abnormal_hepatobiliary_system1.75404264
22MP0002653_abnormal_ependyma_morphology1.72874444
23MP0009053_abnormal_anal_canal1.70441814
24MP0000778_abnormal_nervous_system1.68734809
25MP0000537_abnormal_urethra_morphology1.67043282
26MP0004270_analgesia1.62974514
27MP0010329_abnormal_lipoprotein_level1.60446914
28MP0005253_abnormal_eye_physiology1.58889935
29MP0009780_abnormal_chondrocyte_physiolo1.54072709
30MP0004782_abnormal_surfactant_physiolog1.53792727
31MP0010368_abnormal_lymphatic_system1.53284623
32MP0001529_abnormal_vocalization1.51413748
33MP0009697_abnormal_copulation1.44992666
34MP0005187_abnormal_penis_morphology1.44334871
35MP0001293_anophthalmia1.42769003
36MP0006072_abnormal_retinal_apoptosis1.41595252
37MP0008789_abnormal_olfactory_epithelium1.40993112
38MP0001666_abnormal_nutrient_absorption1.40743826
39MP0000631_abnormal_neuroendocrine_gland1.40699339
40MP0003315_abnormal_perineum_morphology1.38940337
41MP0001984_abnormal_olfaction1.38883142
42MP0001286_abnormal_eye_development1.34616700
43MP0005408_hypopigmentation1.31028432
44MP0008058_abnormal_DNA_repair1.30054881
45MP0005391_vision/eye_phenotype1.29352257
46MP0003937_abnormal_limbs/digits/tail_de1.28563656
47MP0002697_abnormal_eye_size1.28251731
48MP0003942_abnormal_urinary_system1.27157106
49MP0001299_abnormal_eye_distance/1.26735327
50MP0005647_abnormal_sex_gland1.26385832
51MP0005083_abnormal_biliary_tract1.25800932
52MP0003718_maternal_effect1.25221314
53MP0005377_hearing/vestibular/ear_phenot1.22874587
54MP0003878_abnormal_ear_physiology1.22874587
55MP0001764_abnormal_homeostasis1.21916010
56MP0003119_abnormal_digestive_system1.20963771
57MP0002098_abnormal_vibrissa_morphology1.20095711
58MP0005451_abnormal_body_composition1.19639669
59MP0003136_yellow_coat_color1.17008247
60MP0003115_abnormal_respiratory_system1.16641749
61MP0008995_early_reproductive_senescence1.15972741
62MP0010678_abnormal_skin_adnexa1.15811704
63MP0001324_abnormal_eye_pigmentation1.14493317
64MP0003861_abnormal_nervous_system1.14448555
65MP0002084_abnormal_developmental_patter1.12834739
66MP0002909_abnormal_adrenal_gland1.12413112
67MP0002249_abnormal_larynx_morphology1.10727126
68MP0008877_abnormal_DNA_methylation1.08038897
69MP0002184_abnormal_innervation1.07122964
70MP0005195_abnormal_posterior_eye1.04828186
71MP0002751_abnormal_autonomic_nervous1.04042277
72MP0005220_abnormal_exocrine_pancreas1.03644747
73MP0003755_abnormal_palate_morphology1.03429093
74MP0000647_abnormal_sebaceous_gland1.02948692
75MP0003786_premature_aging1.02510338
76MP0003880_abnormal_central_pattern1.02122231
77MP0008007_abnormal_cellular_replicative1.02002895
78MP0005409_darkened_coat_color1.01895250
79MP0004264_abnormal_extraembryonic_tissu1.01735357
80MP0005646_abnormal_pituitary_gland1.01588114
81MP0001346_abnormal_lacrimal_gland1.00705138
82MP0002938_white_spotting1.00645762
83MP0009643_abnormal_urine_homeostasis1.00256073
84MP0002233_abnormal_nose_morphology0.99709718
85MP0003121_genomic_imprinting0.99173024
86MP0002092_abnormal_eye_morphology0.99110199
87MP0003567_abnormal_fetal_cardiomyocyte0.98864067
88MP0003938_abnormal_ear_development0.96966797
89MP0001177_atelectasis0.96863338
90MP0003186_abnormal_redox_activity0.96451503
91MP0010094_abnormal_chromosome_stability0.96305125
92MP0004133_heterotaxia0.96249611
93MP0000428_abnormal_craniofacial_morphol0.96243538
94MP0009703_decreased_birth_body0.94461152
95MP0000049_abnormal_middle_ear0.93729975
96MP0003385_abnormal_body_wall0.93590585
97MP0001119_abnormal_female_reproductive0.93349021
98MP0005670_abnormal_white_adipose0.92429491
99MP0000678_abnormal_parathyroid_gland0.92214025
100MP0010234_abnormal_vibrissa_follicle0.92070969
101MP0003787_abnormal_imprinting0.91494906
102MP0003111_abnormal_nucleus_morphology0.90826515
103MP0000462_abnormal_digestive_system0.90634642
104MP0000534_abnormal_ureter_morphology0.90273450
105MP0003693_abnormal_embryo_hatching0.89789001
106MP0002734_abnormal_mechanical_nocicepti0.89310874
107MP0003698_abnormal_male_reproductive0.88709074
108MP0001188_hyperpigmentation0.88623217
109MP0005499_abnormal_olfactory_system0.87824506
110MP0005394_taste/olfaction_phenotype0.87824506
111MP0001145_abnormal_male_reproductive0.87142694
112MP0004197_abnormal_fetal_growth/weight/0.86853617
113MP0000955_abnormal_spinal_cord0.86590930
114MP0002234_abnormal_pharynx_morphology0.86439319
115MP0002090_abnormal_vision0.85321069
116MP0003868_abnormal_feces_composition0.85271982
117MP0004043_abnormal_pH_regulation0.84983058
118MP0002822_catalepsy0.84889647
119MP0002152_abnormal_brain_morphology0.83974944
120MP0002102_abnormal_ear_morphology0.83118571
121MP0002210_abnormal_sex_determination0.80654012
122MP0003077_abnormal_cell_cycle0.80069861
123MP0003123_paternal_imprinting0.79652977
124MP0004272_abnormal_basement_membrane0.78409968
125MP0009384_cardiac_valve_regurgitation0.78148800
126MP0001486_abnormal_startle_reflex0.77756478
127MP0009672_abnormal_birth_weight0.76722290
128MP0005084_abnormal_gallbladder_morpholo0.75496997
129MP0000609_abnormal_liver_physiology0.75086476
130MP0005395_other_phenotype0.74915908
131MP0000026_abnormal_inner_ear0.73755376
132MP0002557_abnormal_social/conspecific_i0.73732553
133MP0003935_abnormal_craniofacial_develop0.73175438
134MP0000383_abnormal_hair_follicle0.73023977
135MP0003943_abnormal_hepatobiliary_system0.71426024
136MP0000653_abnormal_sex_gland0.71327122
137MP0000516_abnormal_urinary_system0.71212452
138MP0005367_renal/urinary_system_phenotyp0.71212452
139MP0000427_abnormal_hair_cycle0.70574226
140MP0001929_abnormal_gametogenesis0.70562113
141MP0001919_abnormal_reproductive_system0.70204039
142MP0002132_abnormal_respiratory_system0.70175525
143MP0005389_reproductive_system_phenotype0.70118669
144MP0002160_abnormal_reproductive_system0.69775200
145MP0001672_abnormal_embryogenesis/_devel0.69178307
146MP0005380_embryogenesis_phenotype0.69178307
147MP0002085_abnormal_embryonic_tissue0.69164345
148MP0001915_intracranial_hemorrhage0.68558814
149MP0005319_abnormal_enzyme/_coenzyme0.68492870
150MP0003191_abnormal_cellular_cholesterol0.68240395

Predicted human phenotypes

RankGene SetZ-score
1Chorioretinal atrophy (HP:0000533)4.18618786
2Intrahepatic cholestasis (HP:0001406)3.93682161
3Abnormality of monocarboxylic acid metabolism (HP:0010996)3.85692004
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.39165516
5Deep venous thrombosis (HP:0002625)3.37102143
6Hyperglycinuria (HP:0003108)3.29667974
7Pigmentary retinal degeneration (HP:0001146)3.27186545
8Hypobetalipoproteinemia (HP:0003563)3.25025249
9Hyperglycinemia (HP:0002154)3.23541193
10Abnormality of pyrimidine metabolism (HP:0004353)3.21180836
11Papillary thyroid carcinoma (HP:0002895)3.05614220
12Congenital stationary night blindness (HP:0007642)3.00075645
13Prolonged partial thromboplastin time (HP:0003645)2.99672577
14Abnormality of serine family amino acid metabolism (HP:0010894)2.79327549
15Abnormality of glycine metabolism (HP:0010895)2.79327549
16Dyschromatopsia (HP:0007641)2.75610032
17Proximal tubulopathy (HP:0000114)2.74539766
18Pendular nystagmus (HP:0012043)2.74075967
19Cone-rod dystrophy (HP:0000548)2.68471064
20Enlarged kidneys (HP:0000105)2.65547623
21Bony spicule pigmentary retinopathy (HP:0007737)2.63529988
22Abnormality of aspartate family amino acid metabolism (HP:0010899)2.54717532
23Conjugated hyperbilirubinemia (HP:0002908)2.53023625
24Abnormality of sulfur amino acid metabolism (HP:0004339)2.49916919
25Midline defect of the nose (HP:0004122)2.49780193
26Hypolipoproteinemia (HP:0010981)2.48602665
27Abnormality of glutamine family amino acid metabolism (HP:0010902)2.48188070
28Hyperammonemia (HP:0001987)2.43647475
29Central scotoma (HP:0000603)2.42280161
30Abnormality of macular pigmentation (HP:0008002)2.40834438
31Impulsivity (HP:0100710)2.40316145
32Chronic hepatic failure (HP:0100626)2.35030011
33Oligodactyly (hands) (HP:0001180)2.34528969
34Facial hemangioma (HP:0000329)2.34415705
35Gout (HP:0001997)2.34043229
36Hyperlipoproteinemia (HP:0010980)2.33657692
37Fat malabsorption (HP:0002630)2.32623438
38Xanthomatosis (HP:0000991)2.30996084
39Abnormality of nucleobase metabolism (HP:0010932)2.28322621
40Decreased central vision (HP:0007663)2.26397717
41Abnormality of methionine metabolism (HP:0010901)2.23616970
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23311804
43Epidermoid cyst (HP:0200040)2.23311242
44Joint hemorrhage (HP:0005261)2.22787102
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19641478
46Thyroid carcinoma (HP:0002890)2.18272111
47Shawl scrotum (HP:0000049)2.18050357
48Cutaneous finger syndactyly (HP:0010554)2.17311940
49Vitreoretinal degeneration (HP:0000655)2.16869210
50Hypoglycemic coma (HP:0001325)2.16062961
51Hypoalphalipoproteinemia (HP:0003233)2.12767138
52Hepatoblastoma (HP:0002884)2.11553030
53Neoplasm of the liver (HP:0002896)2.10813386
54Glomerulosclerosis (HP:0000096)2.10369253
55Scotoma (HP:0000575)2.10063909
56Focal segmental glomerulosclerosis (HP:0000097)2.08940815
57Abolished electroretinogram (ERG) (HP:0000550)2.06797835
58Oligodactyly (HP:0012165)2.05094452
59Chromsome breakage (HP:0040012)2.04589409
60Hepatocellular carcinoma (HP:0001402)2.03344202
61Complement deficiency (HP:0004431)2.03016202
62Renal hypoplasia (HP:0000089)2.02944285
63Bifid scrotum (HP:0000048)2.02541665
64Delayed CNS myelination (HP:0002188)2.00886505
65Vascular calcification (HP:0004934)2.00066071
66Ketosis (HP:0001946)1.99692202
67True hermaphroditism (HP:0010459)1.98829240
68Abnormality of the labia minora (HP:0012880)1.98083288
69Renal cortical cysts (HP:0000803)1.97881872
70Abnormality of the renal cortex (HP:0011035)1.97595091
71Supernumerary spleens (HP:0009799)1.96604612
72Genital tract atresia (HP:0001827)1.96060236
73Abnormality of serum amino acid levels (HP:0003112)1.94300824
74Vaginal atresia (HP:0000148)1.94123542
75Abnormality of the lower motor neuron (HP:0002366)1.93769349
76Abnormality of urine glucose concentration (HP:0011016)1.92251807
77Glycosuria (HP:0003076)1.92251807
78Aqueductal stenosis (HP:0002410)1.91875863
79Cutaneous syndactyly (HP:0012725)1.90874067
80Preaxial foot polydactyly (HP:0001841)1.90719699
81Anal stenosis (HP:0002025)1.89636961
82High anterior hairline (HP:0009890)1.89558250
83Tubulointerstitial nephritis (HP:0001970)1.88531437
84Esophageal varix (HP:0002040)1.88317194
85Abnormal rod and cone electroretinograms (HP:0008323)1.88104521
86Increased purine levels (HP:0004368)1.87305059
87Hyperuricemia (HP:0002149)1.87305059
88Volvulus (HP:0002580)1.86743792
89Hyperactive renin-angiotensin system (HP:0000841)1.85687058
90Abnormal lung lobation (HP:0002101)1.85047299
91Abnormality of fatty-acid metabolism (HP:0004359)1.84906739
92Gonadotropin excess (HP:0000837)1.84791935
93Bifid tongue (HP:0010297)1.84095873
94Anophthalmia (HP:0000528)1.83945361
95Abnormality of the intrinsic pathway (HP:0010989)1.82697370
96Intestinal atresia (HP:0011100)1.82603956
97Stage 5 chronic kidney disease (HP:0003774)1.82392695
98Steatorrhea (HP:0002570)1.82275186
99Abnormality of purine metabolism (HP:0004352)1.81893513
100Abnormality of the common coagulation pathway (HP:0010990)1.81333058
101Tubular atrophy (HP:0000092)1.81119209
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.81104098
103Nephronophthisis (HP:0000090)1.80663881
104Abnormality of the renal medulla (HP:0100957)1.80625499
105Posterior subcapsular cataract (HP:0007787)1.80115442
106Gastrointestinal atresia (HP:0002589)1.75445360
107Nephroblastoma (Wilms tumor) (HP:0002667)1.75420723
108Hypochromic microcytic anemia (HP:0004840)1.74860349
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74797200
110Absent eyebrow (HP:0002223)1.73500468
111Hyperventilation (HP:0002883)1.73327136
112Facial cleft (HP:0002006)1.72773308
113Cortical dysplasia (HP:0002539)1.72518363
114Absent radius (HP:0003974)1.71959716
115Attenuation of retinal blood vessels (HP:0007843)1.71641772
116Tubulointerstitial abnormality (HP:0001969)1.69918869
117Postaxial hand polydactyly (HP:0001162)1.69576289
118Septo-optic dysplasia (HP:0100842)1.69015395
119Embryonal renal neoplasm (HP:0011794)1.68693691
120Tubulointerstitial fibrosis (HP:0005576)1.68308173
121Bicornuate uterus (HP:0000813)1.68301967
122Pancreatic cysts (HP:0001737)1.68014469
123Renal tubular acidosis (HP:0001947)1.67538847
124Drooling (HP:0002307)1.66634866
125Macular degeneration (HP:0000608)1.66376464
126Coronal craniosynostosis (HP:0004440)1.65716309
127Rimmed vacuoles (HP:0003805)1.65219335
128Gait imbalance (HP:0002141)1.65209056
129Type II diabetes mellitus (HP:0005978)1.65131713
130Osteomalacia (HP:0002749)1.64756025
131Absent forearm bone (HP:0003953)1.64699118
132Aplasia involving forearm bones (HP:0009822)1.64699118
133Lethargy (HP:0001254)1.63967994
134Generalized aminoaciduria (HP:0002909)1.63949601
135Postaxial foot polydactyly (HP:0001830)1.63794130
136Absent eyelashes (HP:0000561)1.63352682
137Congenital malformation of the right heart (HP:0011723)1.62698757
138Double outlet right ventricle (HP:0001719)1.62698757
139Abnormality of the corticospinal tract (HP:0002492)1.62028121
140Increased nuchal translucency (HP:0010880)1.59824547
141Congenital primary aphakia (HP:0007707)1.59113839
142Renal dysplasia (HP:0000110)1.58097433
143Abnormality of the parathyroid morphology (HP:0011766)1.57641250
144Labial hypoplasia (HP:0000066)1.57619718
145Meckel diverticulum (HP:0002245)1.57014933
146Myelomeningocele (HP:0002475)1.56653631
147Medial flaring of the eyebrow (HP:0010747)1.56557268
148Colon cancer (HP:0003003)1.56396627
149Broad alveolar ridges (HP:0000187)1.55241664
150Decreased lacrimation (HP:0000633)1.54325197
151Ectopic kidney (HP:0000086)1.53548421
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.53399805
153Abnormality of the ischium (HP:0003174)1.53101715
154Hyperinsulinemic hypoglycemia (HP:0000825)1.53050251
155Omphalocele (HP:0001539)1.52765433
156Optic nerve hypoplasia (HP:0000609)1.52714318
157Esophageal atresia (HP:0002032)1.50844359
158Absent septum pellucidum (HP:0001331)1.49687457
159Duplication of thumb phalanx (HP:0009942)1.49114185
160Abnormality of the ileum (HP:0001549)1.47365001
161Shoulder girdle muscle weakness (HP:0003547)1.45946603
162Vertebral arch anomaly (HP:0008438)1.45796543
163Nephrogenic diabetes insipidus (HP:0009806)1.45625817
164Alacrima (HP:0000522)1.45422347
165Poor coordination (HP:0002370)1.44747240
166Short tibia (HP:0005736)1.44588691
167Abnormality of the pubic bones (HP:0003172)1.43720562
168Fair hair (HP:0002286)1.41384638
169Preaxial hand polydactyly (HP:0001177)1.40975077
170Thyroid-stimulating hormone excess (HP:0002925)1.40883646
171Triphalangeal thumb (HP:0001199)1.40503805
172Hypoplastic pelvis (HP:0008839)1.39449271
173Hypoplastic female external genitalia (HP:0012815)1.39385554
174Aplasia/Hypoplasia of the uvula (HP:0010293)1.38582878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L4.02326154
2LATS13.15555400
3WNK32.91336304
4EPHB22.91181750
5ZAK2.83305599
6CASK2.76390979
7BCKDK2.74879043
8PNCK2.74186361
9PLK42.62421785
10EPHA22.49342057
11AKT32.29734983
12NUAK12.28005554
13SRPK12.18588398
14FGFR22.09107369
15TTK2.01431896
16MAP3K41.99575500
17GRK11.81986315
18PBK1.81016425
19EPHA41.77157606
20INSRR1.75494975
21BUB11.73657035
22CDK121.69448955
23CAMK1G1.59471216
24TNIK1.57019448
25PASK1.52615617
26NTRK31.49669620
27MET1.47747182
28WNK41.46514003
29CDC71.44955523
30SGK21.42795374
31STK31.40336216
32MARK11.39430223
33STK391.39419864
34MKNK11.39136013
35ERBB41.37829023
36PLK31.37142048
37IRAK31.35648259
38WEE11.32170437
39PINK11.30820794
40ERBB21.28506224
41MAP2K71.25668263
42PKN21.17939870
43PLK21.17896151
44CHEK21.17567096
45NTRK21.15681623
46PLK11.15475678
47FRK1.14744378
48CSNK1G11.13388830
49TRIM281.12826355
50BRD41.12031569
51MAP3K91.11450557
52BRSK21.11130349
53MKNK21.10681496
54AURKB1.04400104
55CSNK1G21.04222724
56SGK4941.01713486
57SGK2231.01713486
58ATR0.99729693
59DYRK30.99699826
60NEK20.99692404
61BMPR1B0.99537840
62BCR0.99323893
63STK40.97329010
64CSNK1A1L0.96534824
65TGFBR10.95006935
66CAMK1D0.94613286
67TAF10.92684425
68PAK40.92584563
69CDK70.91236105
70OBSCN0.90666054
71ERBB30.88712246
72NEK90.87376368
73EIF2AK20.86496809
74CSNK1G30.85000261
75PIK3CA0.82839261
76MAPK130.82084091
77TIE10.81952852
78FGFR30.81651038
79EIF2AK10.81054108
80NEK10.80834466
81TYRO30.80727672
82AURKA0.80311496
83FGFR40.79650660
84SIK10.78121676
85IRAK20.77084060
86ACVR1B0.76999812
87CHUK0.75634840
88SGK30.75091797
89YES10.74413112
90IRAK10.74179550
91ATM0.72984310
92TAOK20.72304428
93CDK80.71853112
94RPS6KB20.71578544
95CDK90.70520913
96RPS6KA40.70474786
97VRK10.70238869
98PDGFRA0.69406634
99CHEK10.69287896
100EPHA30.68987574
101PRKCE0.67506882
102RET0.67011902
103MAP3K100.66736516
104MYLK0.65573476
105FER0.65228805
106BRSK10.64182228
107NLK0.64119502
108MAPK150.62744795
109CDK30.61649890
110OXSR10.58775372
111STK240.58051872
112MAP2K40.57553605
113NEK60.55864793
114CSNK1E0.55760986
115DYRK1B0.55730309
116PRKAA20.55692527
117FGFR10.55678684
118CSNK1D0.55406730
119BRAF0.52634374
120LATS20.52465173
121PTK20.51877242
122TSSK60.49980938
123PRKCI0.49881481
124MAP3K30.49718832
125PRKAA10.49220099
126PRKCG0.48819978
127STK380.48736965
128STK160.48357959
129CDK60.47889827
130CDK40.47208382
131CDK10.47072736
132EIF2AK30.47007282
133DYRK20.45475033
134TLK10.44631248
135CSNK2A10.43573308
136DYRK1A0.43537018
137UHMK10.43512994
138MTOR0.42419880
139RPS6KB10.42189886
140MAPK70.41536799
141PTK60.40864141
142MAPK110.40106794
143MAP2K60.39486349
144KSR10.39432788

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.05938516
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61940202
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43216977
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.39523898
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23456578
6Tryptophan metabolism_Homo sapiens_hsa003802.22527705
7Retinol metabolism_Homo sapiens_hsa008302.19130571
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11203474
9Fatty acid degradation_Homo sapiens_hsa000712.10986085
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10055359
11Propanoate metabolism_Homo sapiens_hsa006402.04956781
12Peroxisome_Homo sapiens_hsa041462.03173076
13Phototransduction_Homo sapiens_hsa047441.99191120
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94603590
15Selenocompound metabolism_Homo sapiens_hsa004501.94205253
16Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.91048575
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.88530618
18Complement and coagulation cascades_Homo sapiens_hsa046101.86416456
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.84482212
20Chemical carcinogenesis_Homo sapiens_hsa052041.84142709
21Butanoate metabolism_Homo sapiens_hsa006501.80897111
22One carbon pool by folate_Homo sapiens_hsa006701.72652849
23Vitamin digestion and absorption_Homo sapiens_hsa049771.70971451
24Arginine biosynthesis_Homo sapiens_hsa002201.67812572
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.66164152
26beta-Alanine metabolism_Homo sapiens_hsa004101.65589847
27Fatty acid metabolism_Homo sapiens_hsa012121.64240030
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.59977162
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59249951
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.55237389
31Nitrogen metabolism_Homo sapiens_hsa009101.53924434
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.52670459
33Phenylalanine metabolism_Homo sapiens_hsa003601.45598514
34Tyrosine metabolism_Homo sapiens_hsa003501.43256092
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.42677919
36Lysine degradation_Homo sapiens_hsa003101.41552634
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40576175
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39176364
39Histidine metabolism_Homo sapiens_hsa003401.37942963
40Steroid biosynthesis_Homo sapiens_hsa001001.32365269
41Pyruvate metabolism_Homo sapiens_hsa006201.31905872
42Nicotine addiction_Homo sapiens_hsa050331.29872446
43Fatty acid elongation_Homo sapiens_hsa000621.29822204
44PPAR signaling pathway_Homo sapiens_hsa033201.28406982
45Adherens junction_Homo sapiens_hsa045201.22756208
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20422295
47Sulfur metabolism_Homo sapiens_hsa009201.18673714
48Tight junction_Homo sapiens_hsa045301.18605691
49Glutathione metabolism_Homo sapiens_hsa004801.18225116
50Biosynthesis of amino acids_Homo sapiens_hsa012301.16555485
51Mismatch repair_Homo sapiens_hsa034301.14381261
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12016487
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10988253
54Carbon metabolism_Homo sapiens_hsa012001.08726506
55Folate biosynthesis_Homo sapiens_hsa007901.06987085
56Starch and sucrose metabolism_Homo sapiens_hsa005001.06720505
57Fat digestion and absorption_Homo sapiens_hsa049751.02665264
58Axon guidance_Homo sapiens_hsa043601.02407941
59Fanconi anemia pathway_Homo sapiens_hsa034601.01911507
60Basal cell carcinoma_Homo sapiens_hsa052170.98387708
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98250787
62Wnt signaling pathway_Homo sapiens_hsa043100.96324091
63Bile secretion_Homo sapiens_hsa049760.95133670
64Homologous recombination_Homo sapiens_hsa034400.94433428
65Oocyte meiosis_Homo sapiens_hsa041140.93035866
66Arginine and proline metabolism_Homo sapiens_hsa003300.92291783
67ABC transporters_Homo sapiens_hsa020100.90550126
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90540581
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87578045
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86527112
71Caffeine metabolism_Homo sapiens_hsa002320.81330226
72Basal transcription factors_Homo sapiens_hsa030220.80381719
73Vitamin B6 metabolism_Homo sapiens_hsa007500.80061763
74Cell cycle_Homo sapiens_hsa041100.76032283
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73185522
76Glutamatergic synapse_Homo sapiens_hsa047240.68834957
77RNA degradation_Homo sapiens_hsa030180.68363063
78Gap junction_Homo sapiens_hsa045400.68285665
79Pyrimidine metabolism_Homo sapiens_hsa002400.67837167
80DNA replication_Homo sapiens_hsa030300.66852009
81Glucagon signaling pathway_Homo sapiens_hsa049220.66189081
82Dorso-ventral axis formation_Homo sapiens_hsa043200.66112049
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66050242
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65628407
85Insulin secretion_Homo sapiens_hsa049110.65357871
86Metabolic pathways_Homo sapiens_hsa011000.64288195
87Sulfur relay system_Homo sapiens_hsa041220.63624342
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63182752
89AMPK signaling pathway_Homo sapiens_hsa041520.62511336
90Hippo signaling pathway_Homo sapiens_hsa043900.62128747
91Taste transduction_Homo sapiens_hsa047420.61540425
92Base excision repair_Homo sapiens_hsa034100.61413729
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60753032
94Protein digestion and absorption_Homo sapiens_hsa049740.59955530
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59327686
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59065909
97Thyroid cancer_Homo sapiens_hsa052160.59019538
98Hedgehog signaling pathway_Homo sapiens_hsa043400.58456276
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58276158
100Protein export_Homo sapiens_hsa030600.57927644
101Long-term depression_Homo sapiens_hsa047300.56969863
102Nucleotide excision repair_Homo sapiens_hsa034200.56800945
103Dopaminergic synapse_Homo sapiens_hsa047280.56464214
104Spliceosome_Homo sapiens_hsa030400.56222262
105Melanogenesis_Homo sapiens_hsa049160.55248416
106Linoleic acid metabolism_Homo sapiens_hsa005910.55107728
107Thyroid hormone synthesis_Homo sapiens_hsa049180.54892223
108Staphylococcus aureus infection_Homo sapiens_hsa051500.54130363
109Glycerolipid metabolism_Homo sapiens_hsa005610.53358136
110RNA transport_Homo sapiens_hsa030130.53101793
111Arachidonic acid metabolism_Homo sapiens_hsa005900.52071174
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50571741
113RNA polymerase_Homo sapiens_hsa030200.50482905
114Cocaine addiction_Homo sapiens_hsa050300.49836664
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47936558
116Circadian rhythm_Homo sapiens_hsa047100.47415619
117Fatty acid biosynthesis_Homo sapiens_hsa000610.46767514
118Endometrial cancer_Homo sapiens_hsa052130.46466846
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45694422
120GABAergic synapse_Homo sapiens_hsa047270.45463518
121Ovarian steroidogenesis_Homo sapiens_hsa049130.44942969
122Fructose and mannose metabolism_Homo sapiens_hsa000510.44910176
123ECM-receptor interaction_Homo sapiens_hsa045120.44799637
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44152492
125Pentose phosphate pathway_Homo sapiens_hsa000300.43381283
126Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42334690
127Circadian entrainment_Homo sapiens_hsa047130.42240100
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42121416
129Galactose metabolism_Homo sapiens_hsa000520.39624831
130Notch signaling pathway_Homo sapiens_hsa043300.38119436
131Purine metabolism_Homo sapiens_hsa002300.37675545
132TGF-beta signaling pathway_Homo sapiens_hsa043500.37187546
133mRNA surveillance pathway_Homo sapiens_hsa030150.35634472
134Non-homologous end-joining_Homo sapiens_hsa034500.35153736

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