EPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.71807295
2cytoplasmic mRNA processing body assembly (GO:0033962)4.33935076
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30839062
4negative regulation of cell killing (GO:0031342)4.30839062
5mitotic sister chromatid cohesion (GO:0007064)4.28276250
6histone H3-K4 methylation (GO:0051568)3.98759186
7activated T cell proliferation (GO:0050798)3.97142544
8histone H3-K36 demethylation (GO:0070544)3.73892344
9neural tube formation (GO:0001841)3.66931341
10peptidyl-lysine trimethylation (GO:0018023)3.57071608
11interferon-gamma production (GO:0032609)3.47960160
12establishment of protein localization to Golgi (GO:0072600)3.31543369
13cellular response to interleukin-15 (GO:0071350)3.28773356
14protein K11-linked deubiquitination (GO:0035871)3.25386302
15histone lysine methylation (GO:0034968)3.24630694
16positive regulation of gamma-delta T cell activation (GO:0046645)3.23517276
17tolerance induction (GO:0002507)3.17372198
18phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16112952
19positive thymic T cell selection (GO:0045059)3.15224011
20positive T cell selection (GO:0043368)3.11504454
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.11078001
22regulation of translation, ncRNA-mediated (GO:0045974)3.11078001
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11078001
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09549655
25alpha-beta T cell differentiation (GO:0046632)3.03124036
26regulation of germinal center formation (GO:0002634)3.02861950
27positive regulation of histone deacetylation (GO:0031065)3.02456933
28positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.02144995
29cellular response to ethanol (GO:0071361)3.00732057
30histone lysine demethylation (GO:0070076)2.94229086
31response to interleukin-15 (GO:0070672)2.90063624
32interkinetic nuclear migration (GO:0022027)2.89914768
33negative regulation of T cell mediated immunity (GO:0002710)2.88363922
34pre-miRNA processing (GO:0031054)2.87400222
35protein targeting to Golgi (GO:0000042)2.79448842
36protein K63-linked deubiquitination (GO:0070536)2.79093173
37histone demethylation (GO:0016577)2.77574161
38CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.76121792
39peptidyl-lysine methylation (GO:0018022)2.75006918
40negative regulation of lymphocyte mediated immunity (GO:0002707)2.74579853
41negative T cell selection (GO:0043383)2.71714669
42negative regulation of histone methylation (GO:0031061)2.71618973
43alpha-beta T cell activation (GO:0046631)2.71609653
44regulation of gamma-delta T cell differentiation (GO:0045586)2.71107659
45negative regulation of immunoglobulin mediated immune response (GO:0002890)2.68639949
46negative regulation of B cell mediated immunity (GO:0002713)2.68639949
47negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.68602260
48histone H3-K9 demethylation (GO:0033169)2.68041402
49T cell selection (GO:0045058)2.67744253
50positive regulation of gene expression, epigenetic (GO:0045815)2.66937379
51positive regulation of Rap GTPase activity (GO:0032854)2.65253087
52T-helper cell differentiation (GO:0042093)2.65055147
53CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.65055147
54retrograde transport, vesicle recycling within Golgi (GO:0000301)2.65043535
55T cell migration (GO:0072678)2.64282551
56regulation of gamma-delta T cell activation (GO:0046643)2.63435721
57histone H3-K9 methylation (GO:0051567)2.63125529
58behavioral response to nicotine (GO:0035095)2.62522618
59cAMP catabolic process (GO:0006198)2.62252293
60positive regulation of granulocyte differentiation (GO:0030854)2.62196490
61regulation of histone deacetylation (GO:0031063)2.61642591
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.60976971
63regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.60976971
64negative regulation of T-helper cell differentiation (GO:0045623)2.60916379
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.60916379
66negative regulation of cAMP-mediated signaling (GO:0043951)2.57411463
67protein dealkylation (GO:0008214)2.57294362
68protein demethylation (GO:0006482)2.57294362
69protein K48-linked deubiquitination (GO:0071108)2.55871217
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.55571623
71regulation of MHC class I biosynthetic process (GO:0045343)2.55287131
72positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55091545
73regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55091545
74negative thymic T cell selection (GO:0045060)2.54950230
75negative regulation of adaptive immune response (GO:0002820)2.54585730
76RNA destabilization (GO:0050779)2.54204575
77embryonic hemopoiesis (GO:0035162)2.53816578
78positive regulation of developmental pigmentation (GO:0048087)2.53630981
79histone methylation (GO:0016571)2.52489283
80thymic T cell selection (GO:0045061)2.52412606
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52080193
82regulation of interleukin-12 biosynthetic process (GO:0045075)2.51901211
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51809617
84histone H4-K16 acetylation (GO:0043984)2.50179808
85T cell differentiation (GO:0030217)2.49964627
86histone H3-K9 modification (GO:0061647)2.45599971
87T cell differentiation involved in immune response (GO:0002292)2.45233766
88alpha-beta T cell differentiation involved in immune response (GO:0002293)2.45233766
89alpha-beta T cell activation involved in immune response (GO:0002287)2.45233766
90regulation of alpha-beta T cell proliferation (GO:0046640)2.44447789
91regulation of RNA export from nucleus (GO:0046831)2.43857348
92regulation of B cell differentiation (GO:0045577)2.43659580
93regulation of Rap GTPase activity (GO:0032317)2.41192251
94monoubiquitinated protein deubiquitination (GO:0035520)2.40493367
95myeloid leukocyte mediated immunity (GO:0002444)2.40196197
96detection of light stimulus involved in visual perception (GO:0050908)2.40026880
97detection of light stimulus involved in sensory perception (GO:0050962)2.40026880
98pericardium development (GO:0060039)2.39509890
99mast cell activation (GO:0045576)2.39415232
100central nervous system projection neuron axonogenesis (GO:0021952)2.39088420
101cellular extravasation (GO:0045123)2.39003772
102embryonic camera-type eye morphogenesis (GO:0048596)2.38757438
103positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.38484390
104nuclear pore complex assembly (GO:0051292)2.38453136
105NIK/NF-kappaB signaling (GO:0038061)2.35827043
106regulation of sister chromatid cohesion (GO:0007063)2.35176728
107regulation of pigment cell differentiation (GO:0050932)2.33468209
108regulation of protein deacetylation (GO:0090311)2.33206567
109positive regulation of B cell differentiation (GO:0045579)2.33058268
110RNA stabilization (GO:0043489)2.32736490
111mRNA stabilization (GO:0048255)2.32736490
112positive regulation of mRNA catabolic process (GO:0061014)2.32578780
113nucleosome disassembly (GO:0006337)2.32452616
114protein-DNA complex disassembly (GO:0032986)2.32452616
115regulation of B cell receptor signaling pathway (GO:0050855)2.31147527
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.30494151
117Peyers patch development (GO:0048541)2.28869600
118mucosal-associated lymphoid tissue development (GO:0048537)2.28869600
119regulation of MHC class II biosynthetic process (GO:0045346)2.28582991
120negative regulation of interleukin-1 beta production (GO:0032691)2.28340123
121stress granule assembly (GO:0034063)2.28169481
122CD4-positive, alpha-beta T cell activation (GO:0035710)2.27531407
123face morphogenesis (GO:0060325)2.25909846
124neutrophil mediated immunity (GO:0002446)2.25694694
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25243018
126forebrain neuron differentiation (GO:0021879)2.25110282
127indolalkylamine metabolic process (GO:0006586)2.25007772
128nucleus localization (GO:0051647)2.23224805
129regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.20965873
130regulation of mRNA catabolic process (GO:0061013)2.20810448
131regulation of granulocyte differentiation (GO:0030852)2.20525108
132growth hormone receptor signaling pathway (GO:0060396)2.20172762
133NLS-bearing protein import into nucleus (GO:0006607)2.19929247
134mRNA splice site selection (GO:0006376)2.18965152
135dorsal/ventral axis specification (GO:0009950)2.17308908
136regulation of NFAT protein import into nucleus (GO:0051532)2.15672672
137B cell homeostasis (GO:0001782)2.13340344
138histone deubiquitination (GO:0016578)2.13161180
139B cell receptor signaling pathway (GO:0050853)2.13129684
140response to pheromone (GO:0019236)2.11583920
141heart morphogenesis (GO:0003007)2.10964554
142positive regulation of protein deacetylation (GO:0090312)2.08706107
143positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.08093628
144positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.08093628
145positive regulation of mitotic sister chromatid separation (GO:1901970)2.08093628
146positive regulation by host of viral transcription (GO:0043923)2.07529279
147intracellular estrogen receptor signaling pathway (GO:0030520)2.06979011
148regulation of telomere maintenance (GO:0032204)2.06760639
149regulation of histone H3-K27 methylation (GO:0061085)2.03539296
150* histone acetylation (GO:0016573)2.00347217
151nerve growth factor signaling pathway (GO:0038180)2.00097390
152regulation of histone methylation (GO:0031060)1.97909435
153regulation of nucleobase-containing compound transport (GO:0032239)1.97326866
154establishment of nucleus localization (GO:0040023)1.96990623
155* internal peptidyl-lysine acetylation (GO:0018393)1.96769520
156corticosteroid receptor signaling pathway (GO:0031958)1.96619025
157* histone H4 acetylation (GO:0043967)1.96323703
158regulation of RNA stability (GO:0043487)1.96248290
159megakaryocyte development (GO:0035855)1.95723242
160regulation of transforming growth factor beta2 production (GO:0032909)1.95047774
161positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.94795794
162peptidyl-threonine phosphorylation (GO:0018107)1.94724908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.21150990
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.89291831
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.12361010
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81271530
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.73195788
6MYC_22102868_ChIP-Seq_BL_Human2.67026033
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.66961702
8ZNF274_21170338_ChIP-Seq_K562_Hela2.54245636
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.51224982
10RUNX_20019798_ChIP-Seq_JUKART_Human2.33047572
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32639589
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.32451442
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30945522
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28569432
15SCL_19346495_ChIP-Seq_HPC-7_Human2.25591421
16* TCF7_22412390_ChIP-Seq_EML_Mouse2.17256396
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13851373
18TAF15_26573619_Chip-Seq_HEK293_Human2.10231599
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.08150744
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.07217447
21VDR_22108803_ChIP-Seq_LS180_Human2.04485706
22IGF1R_20145208_ChIP-Seq_DFB_Human1.99168571
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95919310
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94311664
25* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.84322462
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.80793567
27FUS_26573619_Chip-Seq_HEK293_Human1.76854274
28* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75922879
29FOXM1_23109430_ChIP-Seq_U2OS_Human1.74727760
30* KDM2B_26808549_Chip-Seq_DND41_Human1.73897457
31EWS_26573619_Chip-Seq_HEK293_Human1.71909346
32ER_23166858_ChIP-Seq_MCF-7_Human1.71374505
33EZH2_22144423_ChIP-Seq_EOC_Human1.69782101
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66840575
35P300_19829295_ChIP-Seq_ESCs_Human1.63765325
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61535298
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57659566
38* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57200091
39AR_21572438_ChIP-Seq_LNCaP_Human1.56990460
40* KDM2B_26808549_Chip-Seq_JURKAT_Human1.56621875
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56428523
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54357490
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50408789
44NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46872336
45BCAT_22108803_ChIP-Seq_LS180_Human1.46602461
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45495678
47* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.45152885
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44998892
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43979064
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.43007972
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.42901205
52MYB_26560356_Chip-Seq_TH2_Human1.42889520
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42654023
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41954227
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41794419
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41532731
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.41338946
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40730940
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40589356
60* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38098504
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37970942
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.35394894
63UTX_26944678_Chip-Seq_JUKART_Human1.35239799
64CBP_20019798_ChIP-Seq_JUKART_Human1.33398485
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33398485
66VDR_21846776_ChIP-Seq_THP-1_Human1.32165484
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.30896302
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30608449
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30608449
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30301703
71* CIITA_25753668_ChIP-Seq_RAJI_Human1.29781006
72MYB_26560356_Chip-Seq_TH1_Human1.28969139
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28716560
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28434504
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27626684
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27269896
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27261965
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.26456372
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24691923
80DROSHA_22980978_ChIP-Seq_HELA_Human1.24217255
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24171285
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.23552483
83IRF1_19129219_ChIP-ChIP_H3396_Human1.22893327
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22885242
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.22876805
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22846126
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.21916132
88TP53_16413492_ChIP-PET_HCT116_Human1.21761166
89AR_25329375_ChIP-Seq_VCAP_Human1.21281518
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20689871
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20447375
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19228651
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19012718
94EZH2_27294783_Chip-Seq_NPCs_Mouse1.18770559
95* MAF_26560356_Chip-Seq_TH1_Human1.16413230
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16347900
97VDR_24787735_ChIP-Seq_THP-1_Human1.15359570
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14610402
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13360715
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13323903
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12992762
102RUNX2_22187159_ChIP-Seq_PCA_Human1.12872418
103* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12636449
104KDM2B_26808549_Chip-Seq_K562_Human1.11989431
105* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11383198
106RNF2_27304074_Chip-Seq_NSC_Mouse1.10059875
107GATA3_26560356_Chip-Seq_TH2_Human1.09661960
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.08476373
109SPI1_23127762_ChIP-Seq_K562_Human1.08400864
110* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06856113
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06729073
112CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06384141
113GATA3_27048872_Chip-Seq_THYMUS_Human1.06135171
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06072863
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05940976
116* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05446260
117PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05407329
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.05267417
119* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04296430
120* VDR_24763502_ChIP-Seq_THP-1_Human1.03999935
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03934021
122* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03015915
123RXR_22108803_ChIP-Seq_LS180_Human1.02541577
124CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01140233
125IRF8_27001747_Chip-Seq_BMDM_Mouse1.01113217
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00843465
127AHR_22903824_ChIP-Seq_MCF-7_Human1.00282509
128* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99087046
129BP1_19119308_ChIP-ChIP_Hs578T_Human0.98515940
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98443999
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97732354
132GBX2_23144817_ChIP-Seq_PC3_Human0.97557121
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97321110
134SMRT_27268052_Chip-Seq_Bcells_Human0.97261775
135KDM2B_26808549_Chip-Seq_REH_Human0.97070647
136NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96834711
137SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96438557
138OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96325758
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95621702
140TP53_22573176_ChIP-Seq_HFKS_Human0.95281748
141P53_22387025_ChIP-Seq_ESCs_Mouse0.94867100
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94329010
143* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93728427
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.92441818
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92053522
146STAT3_23295773_ChIP-Seq_U87_Human0.89299389
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88515765
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.88229540
149* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87481411
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.87292181
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.87241853
152SMAD4_21799915_ChIP-Seq_A2780_Human0.85288605
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84577308
154BRD4_25478319_ChIP-Seq_HGPS_Human0.83460960
155* AR_19668381_ChIP-Seq_PC3_Human0.83438308
156TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82761096
157TCF4_23295773_ChIP-Seq_U87_Human0.79551134
158POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76524193
159RING1B_27294783_Chip-Seq_NPCs_Mouse0.75847461

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.36128540
2MP0003787_abnormal_imprinting3.22980369
3MP0008877_abnormal_DNA_methylation2.45179596
4MP0003724_increased_susceptibility_to2.42219401
5MP0003763_abnormal_thymus_physiology2.40096372
6MP0002138_abnormal_hepatobiliary_system2.38360728
7MP0008961_abnormal_basal_metabolism2.34623631
8MP0005076_abnormal_cell_differentiation2.19218381
9MP0002009_preneoplasia1.98741384
10MP0004808_abnormal_hematopoietic_stem1.98098212
11MP0002166_altered_tumor_susceptibility1.93769972
12MP0003121_genomic_imprinting1.93590266
13MP0003303_peritoneal_inflammation1.88170092
14MP0009278_abnormal_bone_marrow1.86076678
15MP0000703_abnormal_thymus_morphology1.75845785
16MP0002638_abnormal_pupillary_reflex1.73141919
17MP0003195_calcinosis1.69695043
18MP0003646_muscle_fatigue1.62171402
19MP0008789_abnormal_olfactory_epithelium1.62015648
20MP0010352_gastrointestinal_tract_polyps1.60999700
21MP0002006_tumorigenesis1.60541372
22MP0005000_abnormal_immune_tolerance1.60299521
23MP0004142_abnormal_muscle_tone1.57738075
24MP0001986_abnormal_taste_sensitivity1.56972433
25MP0002398_abnormal_bone_marrow1.53132837
26MP0002928_abnormal_bile_duct1.51572122
27MP0002396_abnormal_hematopoietic_system1.51355893
28MP0005499_abnormal_olfactory_system1.50982308
29MP0005394_taste/olfaction_phenotype1.50982308
30MP0001800_abnormal_humoral_immune1.50121346
31MP0002735_abnormal_chemical_nociception1.49262095
32MP0004043_abnormal_pH_regulation1.46373318
33MP0003300_gastrointestinal_ulcer1.45437012
34MP0005645_abnormal_hypothalamus_physiol1.43574656
35MP0005187_abnormal_penis_morphology1.40893596
36MP0004130_abnormal_muscle_cell1.40136778
37MP0003943_abnormal_hepatobiliary_system1.39903515
38MP0005075_abnormal_melanosome_morpholog1.39217216
39* MP0000733_abnormal_muscle_development1.36864722
40MP0003935_abnormal_craniofacial_develop1.35699167
41MP0000428_abnormal_craniofacial_morphol1.34330335
42MP0001501_abnormal_sleep_pattern1.32272433
43MP0004381_abnormal_hair_follicle1.30103584
44MP0009785_altered_susceptibility_to1.29687072
45MP0003436_decreased_susceptibility_to1.29546217
46MP0008995_early_reproductive_senescence1.29510126
47MP0003890_abnormal_embryonic-extraembry1.28886670
48MP0002102_abnormal_ear_morphology1.26255835
49MP0003880_abnormal_central_pattern1.26211077
50MP0005025_abnormal_response_to1.25880502
51MP0000465_gastrointestinal_hemorrhage1.24616045
52MP0004510_myositis1.21853539
53MP0001835_abnormal_antigen_presentation1.21356259
54MP0005671_abnormal_response_to1.20839200
55MP0000716_abnormal_immune_system1.19011298
56MP0003866_abnormal_defecation1.16720126
57MP0002420_abnormal_adaptive_immunity1.16654043
58MP0006292_abnormal_olfactory_placode1.16437854
59MP0002452_abnormal_antigen_presenting1.15500136
60MP0000685_abnormal_immune_system1.15155675
61MP0003045_fibrosis1.14555123
62MP0001819_abnormal_immune_cell1.13807373
63MP0003091_abnormal_cell_migration1.13645742
64MP0002249_abnormal_larynx_morphology1.13421543
65MP0005387_immune_system_phenotype1.13307695
66MP0001790_abnormal_immune_system1.13307695
67MP0002277_abnormal_respiratory_mucosa1.12823976
68MP0002419_abnormal_innate_immunity1.10547174
69MP0003828_pulmonary_edema1.10430104
70MP0003115_abnormal_respiratory_system1.09634525
71MP0008057_abnormal_DNA_replication1.09048116
72MP0004742_abnormal_vestibular_system1.07162390
73MP0002925_abnormal_cardiovascular_devel1.06539736
74MP0006276_abnormal_autonomic_nervous1.05547228
75MP0009745_abnormal_behavioral_response1.04007194
76MP0001545_abnormal_hematopoietic_system1.03869465
77MP0005397_hematopoietic_system_phenotyp1.03869465
78MP0000778_abnormal_nervous_system1.03811048
79MP0005253_abnormal_eye_physiology1.02936781
80MP0003755_abnormal_palate_morphology1.02854972
81MP0003183_abnormal_peptide_metabolism1.02313801
82MP0002148_abnormal_hypersensitivity_rea1.01775807
83MP0002116_abnormal_craniofacial_bone1.00123365
84MP0001919_abnormal_reproductive_system0.99662398
85MP0000631_abnormal_neuroendocrine_gland0.98837003
86MP0002932_abnormal_joint_morphology0.98540245
87MP0002722_abnormal_immune_system0.97776356
88MP0001915_intracranial_hemorrhage0.97616808
89MP0010307_abnormal_tumor_latency0.96997072
90MP0002723_abnormal_immune_serum0.96358338
91MP0002067_abnormal_sensory_capabilities0.95777677
92MP0005248_abnormal_Harderian_gland0.95310464
93MP0002822_catalepsy0.94492657
94MP0003937_abnormal_limbs/digits/tail_de0.93586618
95MP0000689_abnormal_spleen_morphology0.93483455
96MP0005386_behavior/neurological_phenoty0.92170428
97MP0004924_abnormal_behavior0.92170428
98MP0001851_eye_inflammation0.92019098
99MP0009703_decreased_birth_body0.90686595
100MP0010368_abnormal_lymphatic_system0.89978617
101MP0001968_abnormal_touch/_nociception0.89925450
102MP0003077_abnormal_cell_cycle0.89736364
103MP0006072_abnormal_retinal_apoptosis0.88934278
104MP0000432_abnormal_head_morphology0.88914033
105MP0005423_abnormal_somatic_nervous0.88705134
106MP0000427_abnormal_hair_cycle0.88361417
107MP0002429_abnormal_blood_cell0.88238456
108MP0008007_abnormal_cellular_replicative0.88219085
109MP0001270_distended_abdomen0.88050903
110MP0002095_abnormal_skin_pigmentation0.87793511
111MP0005310_abnormal_salivary_gland0.87313215
112MP0000767_abnormal_smooth_muscle0.86954124
113MP0009115_abnormal_fat_cell0.86908717
114MP0001486_abnormal_startle_reflex0.86823087
115MP0001849_ear_inflammation0.86415083
116MP0002084_abnormal_developmental_patter0.85371821
117MP0003861_abnormal_nervous_system0.84126379
118MP0001879_abnormal_lymphatic_vessel0.83566869
119MP0000537_abnormal_urethra_morphology0.82167626
120MP0004885_abnormal_endolymph0.82072359
121MP0005174_abnormal_tail_pigmentation0.80600154
122MP0002272_abnormal_nervous_system0.80234926
123MP0002653_abnormal_ependyma_morphology0.79806434
124MP0001873_stomach_inflammation0.79366734
125MP0001502_abnormal_circadian_rhythm0.79082453
126MP0005084_abnormal_gallbladder_morpholo0.78888822
127MP0005367_renal/urinary_system_phenotyp0.78806941
128MP0000516_abnormal_urinary_system0.78806941
129MP0001286_abnormal_eye_development0.78130528
130MP0002405_respiratory_system_inflammati0.77791302
131MP0002177_abnormal_outer_ear0.77654937
132MP0005551_abnormal_eye_electrophysiolog0.77366854
133MP0002088_abnormal_embryonic_growth/wei0.77082868
134MP0003252_abnormal_bile_duct0.76879980
135MP0002085_abnormal_embryonic_tissue0.76867758
136MP0000678_abnormal_parathyroid_gland0.76591225
137MP0003984_embryonic_growth_retardation0.76569665
138MP0000350_abnormal_cell_proliferation0.76287915
139MP0010630_abnormal_cardiac_muscle0.74952171
140MP0009046_muscle_twitch0.74533335
141MP0005646_abnormal_pituitary_gland0.74512183
142MP0001845_abnormal_inflammatory_respons0.74295110
143MP0002693_abnormal_pancreas_physiology0.73903514
144MP0009764_decreased_sensitivity_to0.73758166
145MP0002109_abnormal_limb_morphology0.73383949
146MP0005167_abnormal_blood-brain_barrier0.73047945
147MP0003635_abnormal_synaptic_transmissio0.72888092
148MP0005266_abnormal_metabolism0.72790177
149MP0002933_joint_inflammation0.72116714
150MP0001119_abnormal_female_reproductive0.71018867
151MP0004197_abnormal_fetal_growth/weight/0.70019014
152MP0010094_abnormal_chromosome_stability0.69904035
153MP0005391_vision/eye_phenotype0.69372055
154MP0000266_abnormal_heart_morphology0.68173176

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.27564125
2Volvulus (HP:0002580)4.22313838
3Hyperventilation (HP:0002883)3.54893835
4Stomatitis (HP:0010280)3.52480179
5Papillary thyroid carcinoma (HP:0002895)3.43140948
6Short 4th metacarpal (HP:0010044)3.38785344
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.38785344
8Febrile seizures (HP:0002373)3.04059078
9Elevated erythrocyte sedimentation rate (HP:0003565)2.97602539
10Fair hair (HP:0002286)2.93968556
11Chronic hepatic failure (HP:0100626)2.91202936
12Pancreatic cysts (HP:0001737)2.86352803
13Protruding tongue (HP:0010808)2.82713848
14Broad-based gait (HP:0002136)2.80016470
15Long eyelashes (HP:0000527)2.77217615
16Gaze-evoked nystagmus (HP:0000640)2.74811039
17Abnormal delayed hypersensitivity skin test (HP:0002963)2.73594457
18Clumsiness (HP:0002312)2.64943126
19Macroorchidism (HP:0000053)2.62748014
20Narrow palate (HP:0000189)2.62255633
21Abnormality of the renal cortex (HP:0011035)2.61161157
22Progressive cerebellar ataxia (HP:0002073)2.59121322
23Trigonocephaly (HP:0000243)2.58900830
24Abnormality of B cell number (HP:0010975)2.56873283
25Absent frontal sinuses (HP:0002688)2.55972774
26Midline defect of the nose (HP:0004122)2.55305969
27Recurrent fungal infections (HP:0002841)2.49727524
28Thyroiditis (HP:0100646)2.49240525
29Lip pit (HP:0100267)2.47758973
30Atonic seizures (HP:0010819)2.47754488
31Abnormality of eosinophils (HP:0001879)2.47690276
32Pancreatic fibrosis (HP:0100732)2.45968278
33IgG deficiency (HP:0004315)2.44009132
34Absent speech (HP:0001344)2.43470909
35Molar tooth sign on MRI (HP:0002419)2.40855985
36Abnormality of midbrain morphology (HP:0002418)2.40855985
37Abnormality of the nasal septum (HP:0000419)2.40406084
38Widely spaced teeth (HP:0000687)2.38626958
39Retrobulbar optic neuritis (HP:0100654)2.35548177
40Optic neuritis (HP:0100653)2.35548177
41Abnormality of the 4th metacarpal (HP:0010012)2.33323855
42Abnormality of the intervertebral disk (HP:0005108)2.30976401
43Depressed nasal tip (HP:0000437)2.26739014
44Medial flaring of the eyebrow (HP:0010747)2.26577044
45Myositis (HP:0100614)2.26141125
46Abnormality of T cells (HP:0002843)2.25904937
47Chronic mucocutaneous candidiasis (HP:0002728)2.25505495
48Recurrent cutaneous fungal infections (HP:0011370)2.25505495
49Abnormality of the renal medulla (HP:0100957)2.24924410
50Neoplasm of the adrenal cortex (HP:0100641)2.23962655
51Generalized hypopigmentation of hair (HP:0011358)2.20603313
52Hypoplastic iliac wings (HP:0002866)2.20510380
53Leukocytosis (HP:0001974)2.17135445
54Transitional cell carcinoma of the bladder (HP:0006740)2.16790353
55Recurrent bronchitis (HP:0002837)2.12344701
56Leiomyosarcoma (HP:0100243)2.11629148
57Uterine leiomyosarcoma (HP:0002891)2.11629148
58Supernumerary ribs (HP:0005815)2.11249170
59Hypoplastic labia majora (HP:0000059)2.10651584
60Neoplasm of the tracheobronchial system (HP:0100552)2.07822362
61Decreased circulating renin level (HP:0003351)2.07469075
62Eosinophilia (HP:0001880)2.06874865
63Tented upper lip vermilion (HP:0010804)2.06633165
64Aqueductal stenosis (HP:0002410)2.03229834
65Spondylolisthesis (HP:0003302)2.03010222
66B lymphocytopenia (HP:0010976)2.02754368
67Ectopic kidney (HP:0000086)2.00451186
68Nephronophthisis (HP:0000090)1.99523080
69Combined immunodeficiency (HP:0005387)1.98740437
70Hypoplasia of the thymus (HP:0000778)1.98691009
71Papilledema (HP:0001085)1.98465010
72Encephalitis (HP:0002383)1.98156124
73Bladder neoplasm (HP:0009725)1.97561290
74Bladder carcinoma (HP:0002862)1.97561290
75Abnormal drinking behavior (HP:0030082)1.96621147
76Polydipsia (HP:0001959)1.96621147
77True hermaphroditism (HP:0010459)1.96008352
78Syringomyelia (HP:0003396)1.95180974
79Spinal cord lesions (HP:0100561)1.95180974
80Meningitis (HP:0001287)1.94105539
81Agammaglobulinemia (HP:0004432)1.93387206
82Acute myeloid leukemia (HP:0004808)1.93291816
83Renal cortical cysts (HP:0000803)1.92513430
84Gait imbalance (HP:0002141)1.92217835
85Thyroid carcinoma (HP:0002890)1.91311983
86Heterotopia (HP:0002282)1.91155181
87Excessive salivation (HP:0003781)1.90577322
88Abnormality of the labia majora (HP:0012881)1.90447032
89Dislocated radial head (HP:0003083)1.90276910
90Hematochezia (HP:0002573)1.89318882
91Dialeptic seizures (HP:0011146)1.87324102
92Abnormality of the parietal bone (HP:0002696)1.87029874
93Subacute progressive viral hepatitis (HP:0006572)1.86929682
94Inability to walk (HP:0002540)1.86501253
95Drooling (HP:0002307)1.86473659
96Truncal obesity (HP:0001956)1.85533628
97Stomach cancer (HP:0012126)1.85160682
98Panhypogammaglobulinemia (HP:0003139)1.85018893
99Abnormality of the prostate (HP:0008775)1.84051334
100Attenuation of retinal blood vessels (HP:0007843)1.83086033
101Hepatoblastoma (HP:0002884)1.82650508
102T lymphocytopenia (HP:0005403)1.82641927
103Supernumerary bones of the axial skeleton (HP:0009144)1.82213473
104Thick eyebrow (HP:0000574)1.81542034
105Obsessive-compulsive behavior (HP:0000722)1.81032794
106Deep philtrum (HP:0002002)1.80818334
107Congenital primary aphakia (HP:0007707)1.80461513
108Acute lymphatic leukemia (HP:0006721)1.80161626
109Abnormality of the radial head (HP:0003995)1.80072278
110Shallow orbits (HP:0000586)1.79948520
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.79277616
112Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77452022
113Limited elbow extension (HP:0001377)1.76761894
114Alveolar cell carcinoma (HP:0006519)1.76416321
115Orchitis (HP:0100796)1.75960860
116Broad thumb (HP:0011304)1.75812144
117Absence seizures (HP:0002121)1.75194902
118Poor coordination (HP:0002370)1.75179001
119Optic nerve coloboma (HP:0000588)1.75117606
120Chorioretinal atrophy (HP:0000533)1.74441620
121Hemiplegia (HP:0002301)1.73401485
122Oligodactyly (hands) (HP:0001180)1.71674419
123Pustule (HP:0200039)1.70795239
124Mediastinal lymphadenopathy (HP:0100721)1.70605982
125Bony spicule pigmentary retinopathy (HP:0007737)1.70243215
126Spontaneous hematomas (HP:0007420)1.69922339
127Amyotrophic lateral sclerosis (HP:0007354)1.69781349
128Prominent nose (HP:0000448)1.69761050
129Prostate neoplasm (HP:0100787)1.68943446
130Vasculitis (HP:0002633)1.68747347
131Arterial tortuosity (HP:0005116)1.68552009
132Increased number of teeth (HP:0011069)1.68125107
133Nephrogenic diabetes insipidus (HP:0009806)1.67168292
134Dyskinesia (HP:0100660)1.66675167
135Urethral obstruction (HP:0000796)1.66471051
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.66454708
137Keratoconjunctivitis (HP:0001096)1.66406486
138Abnormality of chromosome segregation (HP:0002916)1.65764426
139Colitis (HP:0002583)1.65463445
140Abnormality of T cell number (HP:0011839)1.64793141
141Abnormal rod and cone electroretinograms (HP:0008323)1.64684512
142Autoimmune hemolytic anemia (HP:0001890)1.64638858
143Genetic anticipation (HP:0003743)1.63965313
144Medulloblastoma (HP:0002885)1.63790356
145Recurrent viral infections (HP:0004429)1.63300404
146Epileptic encephalopathy (HP:0200134)1.62648355
147Hip dysplasia (HP:0001385)1.62546956
148Abnormality of the incisor (HP:0000676)1.62326954
149Large for gestational age (HP:0001520)1.62056624
150Abnormality of the pons (HP:0007361)1.62030091
151Hyperacusis (HP:0010780)1.61391345
152Cutis marmorata (HP:0000965)1.61179106
153Increased nuchal translucency (HP:0010880)1.60357195
154Malignant gastrointestinal tract tumors (HP:0006749)1.59921958
155Gastrointestinal carcinoma (HP:0002672)1.59921958
156Hypochromic microcytic anemia (HP:0004840)1.59796956
157Severe combined immunodeficiency (HP:0004430)1.59793620
158Vitreoretinal degeneration (HP:0000655)1.59720860
159Hemoptysis (HP:0002105)1.59310742
160Oligodontia (HP:0000677)1.58462024
161Hypoplasia of the maxilla (HP:0000327)1.57916640
162Neoplasm of the oral cavity (HP:0100649)1.57157893
163Congenital stationary night blindness (HP:0007642)1.56591143
164Tapered finger (HP:0001182)1.54555809
165Pendular nystagmus (HP:0012043)1.53933701
166Broad palm (HP:0001169)1.53552341
167Open mouth (HP:0000194)1.52922662
168Aortic aneurysm (HP:0004942)1.52118366
169Abnormality of incisor morphology (HP:0011063)1.51958311
170Recurrent bacterial skin infections (HP:0005406)1.49963844
171Aplasia/Hypoplasia of the sternum (HP:0006714)1.49327269
172Oligodactyly (HP:0012165)1.48923556
173Viral hepatitis (HP:0006562)1.48128884
174Sacral dimple (HP:0000960)1.47778455
175Dental malocclusion (HP:0000689)1.47549115
176Vertebral arch anomaly (HP:0008438)1.46896305
177Bicuspid aortic valve (HP:0001647)1.46632898
178Sandal gap (HP:0001852)1.46256645
179Inappropriate behavior (HP:0000719)1.46175897
180Broad phalanges of the hand (HP:0009768)1.45637594
181Synophrys (HP:0000664)1.45620528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.72129905
2CDK123.95825396
3BRD42.63104122
4EEF2K2.58073592
5MAP3K102.36486696
6MAP3K62.11274934
7MAP4K12.02756617
8CASK1.89919344
9CAMKK21.84024888
10DMPK1.81672050
11LATS11.81473334
12CAMK1G1.74023741
13SIK21.71830877
14MAPK151.71028389
15STK101.68028244
16AKT31.67652448
17ICK1.63850503
18FGFR31.63218933
19EPHA31.61024349
20CAMK1D1.56348607
21NLK1.51005618
22CDK91.46856673
23MARK11.45968529
24CHUK1.43122941
25SGK21.43024618
26NTRK21.42556692
27JAK11.39585644
28SGK31.35178613
29FES1.33428041
30MAP4K21.31027715
31FGFR21.31026366
32TXK1.30489419
33MARK31.26324515
34TAOK31.26267781
35SIK31.24829785
36HIPK21.22401727
37ADRBK21.21375221
38BLK1.19264695
39JAK31.18446980
40WNK31.16210034
41NEK21.16090236
42SYK1.15970876
43TYK21.12741453
44PRKD21.12715825
45CDK31.11516524
46PINK11.11113107
47MAP3K41.08663622
48MELK1.05802075
49TGFBR21.05513261
50ITK1.04798270
51IRAK11.04374726
52RIPK11.03168966
53PNCK1.00003036
54MARK20.98816395
55MAPK130.98459977
56PIK3CG0.96288248
57ERBB30.95316133
58PDGFRB0.94719346
59MAP3K130.94401926
60MTOR0.93072538
61STK30.92771070
62TLK10.90262775
63MAP3K140.90230305
64IRAK40.90006105
65CSF1R0.89824258
66STK110.88427637
67TNK20.86383084
68ACVR1B0.86360634
69MAP3K70.86212902
70TGFBR10.84714607
71LCK0.83716876
72EPHB20.82903535
73PIK3CA0.81491809
74LYN0.80736782
75OXSR10.79878899
76KSR10.79732654
77PAK30.79631127
78PRKCQ0.77762541
79GRK10.77413872
80SIK10.76677190
81PRKAA20.76494225
82KIT0.75439577
83WNK10.74739926
84RPS6KA40.74328101
85SGK2230.73765574
86SGK4940.73765574
87NUAK10.73733669
88DYRK1A0.73593429
89OBSCN0.73140163
90CAMK40.71670413
91BMPR1B0.71528475
92RET0.71097041
93TAOK10.70572455
94ZAK0.70400363
95STK40.69717076
96MAP2K70.68555252
97MKNK20.65852101
98RPS6KA20.65803333
99HCK0.65039267
100IKBKE0.64836688
101EPHB10.64586279
102STK380.64446528
103CAMKK10.62717465
104BTK0.62566117
105ATR0.60669128
106CSNK1A1L0.60379720
107PRKCH0.60344850
108MAPK120.59895720
109CDK60.59449891
110DYRK30.59383510
111MAPK70.59383494
112TRPM70.59024222
113ZAP700.58180088
114PRKAA10.58153401
115CLK10.57127352
116RIPK40.56811929
117TNIK0.55825467
118YES10.55541199
119CAMK10.54242875
120ATM0.53318324
121DAPK20.53178856
122CHEK20.52913661
123MAPK140.52671045
124PDGFRA0.52622381
125GRK60.51825199
126PIM10.51032230
127ERBB20.50421321
128BRSK20.50356508
129CSK0.50082278
130SGK10.49884188
131VRK10.49812796
132INSRR0.49360330
133CDK80.48833446
134ALK0.47861051
135PRKD30.47437745
136TEC0.47275372
137TYRO30.47106703
138JAK20.46465921
139RPS6KA50.44884890
140PTK60.44748691
141MAPK80.44430140
142IKBKB0.44277741
143GRK70.43883647
144UHMK10.39971408
145MAP2K40.38492284

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.22009807
2Allograft rejection_Homo sapiens_hsa053302.07332197
3Autoimmune thyroid disease_Homo sapiens_hsa053202.00767989
4Asthma_Homo sapiens_hsa053101.84130208
5B cell receptor signaling pathway_Homo sapiens_hsa046621.76787565
6Type I diabetes mellitus_Homo sapiens_hsa049401.74329816
7Primary immunodeficiency_Homo sapiens_hsa053401.71474358
8Colorectal cancer_Homo sapiens_hsa052101.66939890
9Endometrial cancer_Homo sapiens_hsa052131.60288875
10T cell receptor signaling pathway_Homo sapiens_hsa046601.56129213
11Chronic myeloid leukemia_Homo sapiens_hsa052201.56122913
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47898958
13Pancreatic cancer_Homo sapiens_hsa052121.43360430
14Osteoclast differentiation_Homo sapiens_hsa043801.39022396
15Dorso-ventral axis formation_Homo sapiens_hsa043201.31494376
16Notch signaling pathway_Homo sapiens_hsa043301.31235238
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30965043
18MicroRNAs in cancer_Homo sapiens_hsa052061.29172574
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.29065532
20Prolactin signaling pathway_Homo sapiens_hsa049171.28316629
21Adherens junction_Homo sapiens_hsa045201.28082917
22Neurotrophin signaling pathway_Homo sapiens_hsa047221.25961193
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25299162
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24179054
25Non-small cell lung cancer_Homo sapiens_hsa052231.24020269
26Acute myeloid leukemia_Homo sapiens_hsa052211.23383638
27Toxoplasmosis_Homo sapiens_hsa051451.22265680
28Phototransduction_Homo sapiens_hsa047441.21069555
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20408026
30Regulation of autophagy_Homo sapiens_hsa041401.19009732
31Nicotine addiction_Homo sapiens_hsa050331.18008516
32Lysine degradation_Homo sapiens_hsa003101.17623627
33FoxO signaling pathway_Homo sapiens_hsa040681.17588243
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17159397
35Type II diabetes mellitus_Homo sapiens_hsa049301.12483061
36Renal cell carcinoma_Homo sapiens_hsa052111.12404301
37mTOR signaling pathway_Homo sapiens_hsa041501.11233596
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11027499
39Staphylococcus aureus infection_Homo sapiens_hsa051501.10075642
40Chemokine signaling pathway_Homo sapiens_hsa040621.09999410
41Taste transduction_Homo sapiens_hsa047421.09204481
42TNF signaling pathway_Homo sapiens_hsa046681.08691927
43Herpes simplex infection_Homo sapiens_hsa051681.06726755
44Prostate cancer_Homo sapiens_hsa052151.06220758
45Viral myocarditis_Homo sapiens_hsa054161.05712437
46Leishmaniasis_Homo sapiens_hsa051401.04627950
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04236594
48Glioma_Homo sapiens_hsa052141.03212904
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.02167426
50Small cell lung cancer_Homo sapiens_hsa052221.01833419
51Hepatitis B_Homo sapiens_hsa051611.01381713
52ErbB signaling pathway_Homo sapiens_hsa040121.00859752
53Wnt signaling pathway_Homo sapiens_hsa043101.00286713
54Measles_Homo sapiens_hsa051621.00034313
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98920760
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98789746
57Morphine addiction_Homo sapiens_hsa050320.98656966
58MAPK signaling pathway_Homo sapiens_hsa040100.98446336
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97695304
60Basal cell carcinoma_Homo sapiens_hsa052170.97683317
61Choline metabolism in cancer_Homo sapiens_hsa052310.97287136
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96068705
63Linoleic acid metabolism_Homo sapiens_hsa005910.96039444
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95647347
65HTLV-I infection_Homo sapiens_hsa051660.93160455
66Nitrogen metabolism_Homo sapiens_hsa009100.92306715
67Systemic lupus erythematosus_Homo sapiens_hsa053220.92168795
68Circadian rhythm_Homo sapiens_hsa047100.92140822
69GnRH signaling pathway_Homo sapiens_hsa049120.91653370
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.90910416
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90330010
72ABC transporters_Homo sapiens_hsa020100.89431065
73Estrogen signaling pathway_Homo sapiens_hsa049150.89367241
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87551773
75Olfactory transduction_Homo sapiens_hsa047400.87325778
76mRNA surveillance pathway_Homo sapiens_hsa030150.86074088
77Platelet activation_Homo sapiens_hsa046110.84840745
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84751831
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84440478
80Proteoglycans in cancer_Homo sapiens_hsa052050.83697021
81VEGF signaling pathway_Homo sapiens_hsa043700.82781289
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82242139
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.82233368
84Influenza A_Homo sapiens_hsa051640.81513703
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81202218
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80665935
87Axon guidance_Homo sapiens_hsa043600.79950594
88Pathways in cancer_Homo sapiens_hsa052000.79450040
89Cholinergic synapse_Homo sapiens_hsa047250.79404613
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79246377
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77916961
92Insulin resistance_Homo sapiens_hsa049310.77437238
93Circadian entrainment_Homo sapiens_hsa047130.77233551
94Apoptosis_Homo sapiens_hsa042100.77140596
95Hippo signaling pathway_Homo sapiens_hsa043900.75628715
96cAMP signaling pathway_Homo sapiens_hsa040240.74956817
97TGF-beta signaling pathway_Homo sapiens_hsa043500.74887663
98Ether lipid metabolism_Homo sapiens_hsa005650.74699419
99Rheumatoid arthritis_Homo sapiens_hsa053230.74652570
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74038788
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73829719
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73449100
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.73420203
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.73057378
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72990163
106Long-term potentiation_Homo sapiens_hsa047200.72662077
107Focal adhesion_Homo sapiens_hsa045100.72218827
108RNA degradation_Homo sapiens_hsa030180.71633176
109Cell cycle_Homo sapiens_hsa041100.71628572
110Hematopoietic cell lineage_Homo sapiens_hsa046400.71593119
111Rap1 signaling pathway_Homo sapiens_hsa040150.70834653
112Ovarian steroidogenesis_Homo sapiens_hsa049130.70360313
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69790095
114Oxytocin signaling pathway_Homo sapiens_hsa049210.69771048
115Inositol phosphate metabolism_Homo sapiens_hsa005620.69767120
116Serotonergic synapse_Homo sapiens_hsa047260.69647438
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68613032
118Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67991040
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67765806
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66206368
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65860383
122Viral carcinogenesis_Homo sapiens_hsa052030.65565259
123Renin secretion_Homo sapiens_hsa049240.65396506
124Calcium signaling pathway_Homo sapiens_hsa040200.65208676
125Cocaine addiction_Homo sapiens_hsa050300.65120548
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64682040
127Dilated cardiomyopathy_Homo sapiens_hsa054140.64254480
128Glutamatergic synapse_Homo sapiens_hsa047240.64154852
129Tuberculosis_Homo sapiens_hsa051520.64049269
130Ras signaling pathway_Homo sapiens_hsa040140.63745476
131Long-term depression_Homo sapiens_hsa047300.62795829
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62593330
133Fanconi anemia pathway_Homo sapiens_hsa034600.61670344
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61650386
135Antigen processing and presentation_Homo sapiens_hsa046120.61272996
136Amphetamine addiction_Homo sapiens_hsa050310.60628782
137Basal transcription factors_Homo sapiens_hsa030220.59930795
138African trypanosomiasis_Homo sapiens_hsa051430.59083739
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58883357
140GABAergic synapse_Homo sapiens_hsa047270.57561571
141Alcoholism_Homo sapiens_hsa050340.57553798
142Malaria_Homo sapiens_hsa051440.55025478
143Salivary secretion_Homo sapiens_hsa049700.53182233
144Dopaminergic synapse_Homo sapiens_hsa047280.52734553
145Insulin secretion_Homo sapiens_hsa049110.52064959
146Vascular smooth muscle contraction_Homo sapiens_hsa042700.51898398

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