EPCAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)8.06593906
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.34534831
3interferon-gamma secretion (GO:0072643)6.74375695
4desmosome organization (GO:0002934)6.18048070
5hemidesmosome assembly (GO:0031581)6.08237211
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.90489340
7calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.75876339
8regulation of guanylate cyclase activity (GO:0031282)5.74007195
9intestinal absorption (GO:0050892)5.66295697
10UDP-N-acetylglucosamine metabolic process (GO:0006047)5.62624247
11NADH metabolic process (GO:0006734)5.52799364
12regulation of water loss via skin (GO:0033561)5.27785000
13hepatocyte apoptotic process (GO:0097284)5.20442942
14maintenance of gastrointestinal epithelium (GO:0030277)5.12782349
15negative regulation of keratinocyte proliferation (GO:0010839)4.90964527
16Golgi transport vesicle coating (GO:0048200)4.74184176
17COPI coating of Golgi vesicle (GO:0048205)4.74184176
18cellular glucuronidation (GO:0052695)4.68666827
19epoxygenase P450 pathway (GO:0019373)4.63799935
20glucuronate metabolic process (GO:0019585)4.59115023
21uronic acid metabolic process (GO:0006063)4.59115023
22tight junction assembly (GO:0070830)4.55309195
23establishment of skin barrier (GO:0061436)4.40215949
24regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.33746311
25endocrine process (GO:0050886)4.33746311
26regulation of systemic arterial blood pressure by hormone (GO:0001990)4.33746311
27epithelial structure maintenance (GO:0010669)4.15915460
28positive regulation of guanylate cyclase activity (GO:0031284)4.10434949
29trophectodermal cell differentiation (GO:0001829)4.10002265
30renal system process involved in regulation of blood volume (GO:0001977)4.05856770
31positive regulation of respiratory burst (GO:0060267)4.05590109
32intestinal cholesterol absorption (GO:0030299)4.05202902
33regulation of systemic arterial blood pressure (GO:0003073)3.98858942
34multicellular organismal water homeostasis (GO:0050891)3.90924664
35regulation of cholesterol homeostasis (GO:2000188)3.87500571
36keratinocyte development (GO:0003334)3.87374348
37sphingomyelin metabolic process (GO:0006684)3.85847857
38purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.85236348
393-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.85236348
40fat-soluble vitamin biosynthetic process (GO:0042362)3.83574071
41nucleotide-sugar biosynthetic process (GO:0009226)3.78441340
42columnar/cuboidal epithelial cell development (GO:0002066)3.78365084
43very-low-density lipoprotein particle assembly (GO:0034379)3.76604382
44receptor guanylyl cyclase signaling pathway (GO:0007168)3.75741754
45epithelial cell-cell adhesion (GO:0090136)3.75408802
46angiotensin maturation (GO:0002003)3.74322473
47regulation of cellular extravasation (GO:0002691)3.73677771
48glandular epithelial cell differentiation (GO:0002067)3.72759832
49flavonoid metabolic process (GO:0009812)3.72017436
50fructose metabolic process (GO:0006000)3.70155975
51urea cycle (GO:0000050)3.69032626
52digestive system process (GO:0022600)3.68922765
53lipoprotein transport (GO:0042953)3.68127292
54actin filament depolymerization (GO:0030042)3.66084133
55GDP-mannose metabolic process (GO:0019673)3.63295704
56digestion (GO:0007586)3.61810287
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57349615
58O-glycan processing (GO:0016266)3.56918333
59antibacterial humoral response (GO:0019731)3.56130765
60antimicrobial humoral response (GO:0019730)3.50490766
61positive regulation of epidermal cell differentiation (GO:0045606)3.48609822
62hormone catabolic process (GO:0042447)3.44499654
63glutamine family amino acid biosynthetic process (GO:0009084)3.44414098
64proline biosynthetic process (GO:0006561)3.43024330
65ventricular cardiac muscle cell action potential (GO:0086005)3.42174092
66regulation of cGMP biosynthetic process (GO:0030826)3.42006109
67urea metabolic process (GO:0019627)3.41889868
68ethanol oxidation (GO:0006069)3.39817681
69regulation of chemokine secretion (GO:0090196)3.37672653
70drug metabolic process (GO:0017144)3.34997896
71positive regulation of Cdc42 GTPase activity (GO:0043089)3.29954397
72diacylglycerol metabolic process (GO:0046339)3.27596864
73protein retention in ER lumen (GO:0006621)3.27194512
74positive regulation of actin filament depolymerization (GO:0030836)3.27046693
75oligosaccharide biosynthetic process (GO:0009312)3.26633094
76regulation of pseudopodium assembly (GO:0031272)3.26270614
77thyroid hormone metabolic process (GO:0042403)3.23804021
78diol metabolic process (GO:0034311)3.23423996
79positive regulation of glycoprotein metabolic process (GO:1903020)3.23354344
80sulfate transmembrane transport (GO:1902358)3.22161922
81glomerular filtration (GO:0003094)3.16533250
82vitamin transport (GO:0051180)3.16050943
83negative regulation of cell fate specification (GO:0009996)3.16006852
84galactose catabolic process (GO:0019388)3.14634415
85renal absorption (GO:0070293)3.14396765
86positive regulation of establishment of protein localization to plasma membrane (GO:0090004)3.13988239
87cell differentiation involved in embryonic placenta development (GO:0060706)3.13925309
88water homeostasis (GO:0030104)3.13906901
89plasma lipoprotein particle assembly (GO:0034377)3.13264373
90endocrine pancreas development (GO:0031018)3.11436656
91regulation of vitamin metabolic process (GO:0030656)3.07642297
92regulation of cardioblast differentiation (GO:0051890)3.06695247
93protein autoprocessing (GO:0016540)3.06516758
94regulation of keratinocyte proliferation (GO:0010837)3.06440421
95ethanol metabolic process (GO:0006067)3.06112902
96branching involved in mammary gland duct morphogenesis (GO:0060444)3.05728479
97nucleoside diphosphate biosynthetic process (GO:0009133)3.04031940
98renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.03435471
99nitrogen cycle metabolic process (GO:0071941)3.02642909
100glycolipid catabolic process (GO:0019377)3.02624625
101phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.99624442
102pyrimidine-containing compound transmembrane transport (GO:0072531)2.98874512
103renal filtration (GO:0097205)2.98583064
104nucleotide-sugar metabolic process (GO:0009225)2.96511526
105lung secretory cell differentiation (GO:0061140)2.96371670
106transcytosis (GO:0045056)2.96133490
107fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94089182
108homocysteine metabolic process (GO:0050667)2.93203797
109positive regulation of protein localization to plasma membrane (GO:1903078)2.91988263
110sulfur compound transport (GO:0072348)2.89171032
111COPII vesicle coating (GO:0048208)2.86988451
112vitamin A metabolic process (GO:0006776)2.86774723
113membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85859035
114regulation of cell fate specification (GO:0042659)2.85858341
115keratinocyte proliferation (GO:0043616)2.85129902
116branching involved in labyrinthine layer morphogenesis (GO:0060670)2.84975501
117glycosphingolipid catabolic process (GO:0046479)2.84724659
118negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.84183553
119sphingolipid catabolic process (GO:0030149)2.83561261
120cobalamin metabolic process (GO:0009235)2.82942365
121cellular response to vitamin D (GO:0071305)2.82740235
122protein-lipid complex assembly (GO:0065005)2.82556433
123gap junction assembly (GO:0016264)2.82310252
124drug transmembrane transport (GO:0006855)2.80279372
125drug transport (GO:0015893)2.80082300
126sodium ion homeostasis (GO:0055078)2.79786444
127negative regulation of cell fate commitment (GO:0010454)2.79738118
128proline metabolic process (GO:0006560)2.79665429
129positive regulation of pseudopodium assembly (GO:0031274)2.77204580
130peptide catabolic process (GO:0043171)2.75752439
131sulfate transport (GO:0008272)2.75378500
132cell-cell junction assembly (GO:0007043)2.75179143
133positive regulation of epidermis development (GO:0045684)2.73837258
134auditory receptor cell differentiation (GO:0042491)2.70531203
135sphingoid metabolic process (GO:0046519)2.69238706
136modified amino acid transport (GO:0072337)2.69232148
137positive regulation of glycoprotein biosynthetic process (GO:0010560)2.68505548
138membrane budding (GO:0006900)2.67777381
139negative regulation of protein tyrosine kinase activity (GO:0061099)2.64497334
140cellular response to hepatocyte growth factor stimulus (GO:0035729)2.62097529
141response to hepatocyte growth factor (GO:0035728)2.62097529
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60984529
143hair cell differentiation (GO:0035315)2.58948320
144adhesion of symbiont to host cell (GO:0044650)2.58611667
145virion attachment to host cell (GO:0019062)2.58611667
146thyroid hormone generation (GO:0006590)2.58607037
147positive regulation of interleukin-8 secretion (GO:2000484)2.56634697
148bile acid and bile salt transport (GO:0015721)2.56395049
149regulation of bile acid biosynthetic process (GO:0070857)2.55289605
150regulation of proton transport (GO:0010155)2.54910178
151peptide hormone processing (GO:0016486)2.54151421
152sphingosine metabolic process (GO:0006670)2.53941364
153regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53874366
154membrane repolarization during action potential (GO:0086011)2.53606240
155decidualization (GO:0046697)2.52678765
156epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51145649
157vitamin transmembrane transport (GO:0035461)2.50635962
158regulation of viral release from host cell (GO:1902186)2.47804737
159regulation of respiratory burst (GO:0060263)2.46325511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.62741265
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.91858057
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.69691575
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.38083974
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.35284558
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.16920160
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.94742749
8GATA6_25053715_ChIP-Seq_YYC3_Human2.75480120
9GATA4_25053715_ChIP-Seq_YYC3_Human2.71823927
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67434635
11ZNF263_19887448_ChIP-Seq_K562_Human2.57251380
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.54684331
13AR_21909140_ChIP-Seq_LNCAP_Human2.47951607
14SOX2_20726797_ChIP-Seq_SW620_Human2.44916602
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.37436487
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25587782
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.21207186
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.18728561
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18095789
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15848172
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.09596180
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.07804570
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00886006
24ATF3_27146783_Chip-Seq_COLON_Human1.91218675
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.90559352
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85279365
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.85204423
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.84952814
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81472932
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80920409
31RACK7_27058665_Chip-Seq_MCF-7_Human1.76061978
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.75290418
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74442796
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74442796
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73995585
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.71499154
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70891118
38ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64268492
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63054759
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62827021
41EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.60321854
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60102945
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59080449
44CLOCK_20551151_ChIP-Seq_293T_Human1.57554687
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.57016237
46KLF5_25053715_ChIP-Seq_YYC3_Human1.50624742
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.49529494
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.49529494
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.49529494
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49379610
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.48808306
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47568868
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44442812
54HNF4A_19822575_ChIP-Seq_HepG2_Human1.44053022
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43000312
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42336325
57MYC_18555785_ChIP-Seq_MESCs_Mouse1.42160620
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.40449615
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.38070280
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36340364
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34563626
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34001337
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32291026
64P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31337971
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28961249
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28781475
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28056830
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27648864
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26316211
70OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25328328
71CHD1_26751641_Chip-Seq_LNCaP_Human1.21612484
72NANOG_18692474_ChIP-Seq_MEFs_Mouse1.21039809
73CDX2_22108803_ChIP-Seq_LS180_Human1.20431863
74FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18853543
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14062441
76SOX2_18692474_ChIP-Seq_MEFs_Mouse1.13900653
77FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13328437
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12021549
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09630872
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.08580948
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08553690
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08182366
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07971278
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06161788
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05785093
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04833221
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03814552
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03349238
89NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01623755
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01233467
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00956659
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98729859
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97737683
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97107209
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96790876
96TCF4_18268006_ChIP-ChIP_LS174T_Human0.96574906
97* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96572362
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95751948
99FOXM1_23109430_ChIP-Seq_U2OS_Human0.94309688
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94029844
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.94004176
102ELF5_23300383_ChIP-Seq_T47D_Human0.93768500
103ESR1_20079471_ChIP-ChIP_T-47D_Human0.92394878
104NANOG_18692474_ChIP-Seq_MESCs_Mouse0.90252056
105CREB1_26743006_Chip-Seq_LNCaP_Human0.89531311
106E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89470734
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89033992
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88022263
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87130977
110GATA1_22025678_ChIP-Seq_K562_Human0.86370178
111NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86349884
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84967087
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84620674
114KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84576418
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83798686
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83349672
117TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83217178
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82965226
119KAP1_27257070_Chip-Seq_ESCs_Mouse0.81448389
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.81183007
121UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79635434
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.79464879
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.77160141
124PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75033504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.75557914
2MP0004264_abnormal_extraembryonic_tissu4.32410955
3MP0002139_abnormal_hepatobiliary_system4.28392576
4MP0000462_abnormal_digestive_system3.26630795
5MP0005365_abnormal_bile_salt3.10487415
6MP0000537_abnormal_urethra_morphology3.00390325
7MP0003878_abnormal_ear_physiology2.95204740
8MP0005377_hearing/vestibular/ear_phenot2.95204740
9MP0010352_gastrointestinal_tract_polyps2.89402190
10MP0003866_abnormal_defecation2.66000266
11MP0001666_abnormal_nutrient_absorption2.65694373
12MP0003283_abnormal_digestive_organ2.54240006
13MP0002796_impaired_skin_barrier2.52361365
14MP0004147_increased_porphyrin_level2.51808990
15MP0010678_abnormal_skin_adnexa2.49710538
16MP0003693_abnormal_embryo_hatching2.35792495
17MP0003300_gastrointestinal_ulcer2.29234351
18MP0002254_reproductive_system_inflammat2.25715849
19MP0002098_abnormal_vibrissa_morphology2.10791633
20MP0003941_abnormal_skin_development2.06497844
21MP0001849_ear_inflammation2.01222588
22MP0000490_abnormal_crypts_of1.90612341
23MP0003868_abnormal_feces_composition1.89502736
24MP0001873_stomach_inflammation1.79456921
25MP0000477_abnormal_intestine_morphology1.73954955
26MP0000566_synostosis1.73694463
27MP0003453_abnormal_keratinocyte_physiol1.69979254
28MP0005501_abnormal_skin_physiology1.68821661
29MP0010155_abnormal_intestine_physiology1.67745441
30MP0004043_abnormal_pH_regulation1.64977630
31MP0005381_digestive/alimentary_phenotyp1.60776665
32MP0005360_urolithiasis1.56995714
33MP0005332_abnormal_amino_acid1.56164923
34MP0010329_abnormal_lipoprotein_level1.54407169
35MP0006054_spinal_hemorrhage1.53714014
36MP0009780_abnormal_chondrocyte_physiolo1.53256696
37MP0005409_darkened_coat_color1.52420067
38MP0004957_abnormal_blastocyst_morpholog1.48716632
39MP0000383_abnormal_hair_follicle1.46822022
40MP0003315_abnormal_perineum_morphology1.45683573
41MP0001216_abnormal_epidermal_layer1.43971670
42MP0001663_abnormal_digestive_system1.43896001
43MP0003705_abnormal_hypodermis_morpholog1.42649271
44MP0000613_abnormal_salivary_gland1.41142110
45MP0004019_abnormal_vitamin_homeostasis1.40457305
46MP0000538_abnormal_urinary_bladder1.36073081
47MP0002060_abnormal_skin_morphology1.32317299
48MP0001664_abnormal_digestion1.31246320
49MP0003566_abnormal_cell_adhesion1.29117817
50MP0000762_abnormal_tongue_morphology1.27294309
51MP0000678_abnormal_parathyroid_gland1.26675656
52MP0002876_abnormal_thyroid_physiology1.25616293
53MP0001188_hyperpigmentation1.25521314
54MP0009643_abnormal_urine_homeostasis1.25342287
55MP0000467_abnormal_esophagus_morphology1.21895681
56MP0003806_abnormal_nucleotide_metabolis1.20565242
57MP0000377_abnormal_hair_follicle1.20013269
58MP0003119_abnormal_digestive_system1.18107086
59MP0001485_abnormal_pinna_reflex1.18090357
60MP0002234_abnormal_pharynx_morphology1.17493991
61MP0008004_abnormal_stomach_pH1.16608055
62MP0000516_abnormal_urinary_system1.15772887
63MP0005367_renal/urinary_system_phenotyp1.15772887
64MP0001765_abnormal_ion_homeostasis1.13192454
65MP0005310_abnormal_salivary_gland1.12666466
66MP0009053_abnormal_anal_canal1.07608095
67MP0001346_abnormal_lacrimal_gland1.05381575
68MP0005076_abnormal_cell_differentiation1.02887409
69MP0003123_paternal_imprinting1.01896193
70MP0004858_abnormal_nervous_system1.01389356
71MP0001881_abnormal_mammary_gland1.00891892
72MP0009840_abnormal_foam_cell0.99989754
73MP0005085_abnormal_gallbladder_physiolo0.99440337
74MP0001756_abnormal_urination0.99168803
75MP0010030_abnormal_orbit_morphology0.98994646
76MP0001764_abnormal_homeostasis0.98751762
77MP0000470_abnormal_stomach_morphology0.97222233
78MP0002277_abnormal_respiratory_mucosa0.96332875
79MP0005166_decreased_susceptibility_to0.96067965
80MP0002118_abnormal_lipid_homeostasis0.94039495
81MP0003183_abnormal_peptide_metabolism0.93495562
82MP0004947_skin_inflammation0.92704401
83MP0005275_abnormal_skin_tensile0.90804931
84MP0000627_abnormal_mammary_gland0.90799787
85MP0005248_abnormal_Harderian_gland0.87373850
86MP0000579_abnormal_nail_morphology0.87220859
87MP0010771_integument_phenotype0.86817073
88MP0002166_altered_tumor_susceptibility0.86630489
89MP0005220_abnormal_exocrine_pancreas0.86013072
90MP0005670_abnormal_white_adipose0.85439381
91MP0000609_abnormal_liver_physiology0.84220055
92MP0002009_preneoplasia0.84046021
93MP0005451_abnormal_body_composition0.82142402
94MP0005023_abnormal_wound_healing0.81296771
95MP0002896_abnormal_bone_mineralization0.81208274
96MP0004782_abnormal_surfactant_physiolog0.80253289
97MP0005319_abnormal_enzyme/_coenzyme0.76829305
98MP0002822_catalepsy0.75464070
99MP0005448_abnormal_energy_balance0.74404890
100MP0002909_abnormal_adrenal_gland0.74123942
101MP0004272_abnormal_basement_membrane0.74082702
102MP0003879_abnormal_hair_cell0.74061923
103MP0003252_abnormal_bile_duct0.73887844
104MP0010386_abnormal_urinary_bladder0.73663691
105MP0004270_analgesia0.72467233
106MP0002138_abnormal_hepatobiliary_system0.72412003
107MP0005636_abnormal_mineral_homeostasis0.72269971
108MP0002877_abnormal_melanocyte_morpholog0.71668931
109MP0009379_abnormal_foot_pigmentation0.71288913
110MP0002136_abnormal_kidney_physiology0.69467836
111MP0005666_abnormal_adipose_tissue0.68078134
112MP0003953_abnormal_hormone_level0.65454587
113MP0010307_abnormal_tumor_latency0.65203748
114MP0001944_abnormal_pancreas_morphology0.64570036
115MP0002006_tumorigenesis0.64099720
116MP0001727_abnormal_embryo_implantation0.64084439
117MP0000427_abnormal_hair_cycle0.63955603
118MP0002111_abnormal_tail_morphology0.60562901
119* MP0001730_embryonic_growth_arrest0.60309344
120MP0000003_abnormal_adipose_tissue0.59874966
121MP0008872_abnormal_physiological_respon0.59804888
122MP0005187_abnormal_penis_morphology0.59512210
123MP0003045_fibrosis0.59105783
124MP0002078_abnormal_glucose_homeostasis0.58968585
125MP0009384_cardiac_valve_regurgitation0.58424304
126MP0008789_abnormal_olfactory_epithelium0.58367514
127MP0008875_abnormal_xenobiotic_pharmacok0.57647107
128MP0002971_abnormal_brown_adipose0.57377119
129MP0003890_abnormal_embryonic-extraembry0.56571201
130MP0003718_maternal_effect0.56487685
131* MP0002086_abnormal_extraembryonic_tissu0.55829952
132MP0003936_abnormal_reproductive_system0.54694948
133MP0004185_abnormal_adipocyte_glucose0.54336913
134MP0009672_abnormal_birth_weight0.52355479
135MP0005058_abnormal_lysosome_morphology0.52293086
136MP0000230_abnormal_systemic_arterial0.51529425

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.94649944
2Onycholysis (HP:0001806)5.47050867
3Pili torti (HP:0003777)5.39328663
4Ileus (HP:0002595)5.19880872
5Milia (HP:0001056)4.52107317
6Fragile nails (HP:0001808)4.43511873
7Decreased circulating renin level (HP:0003351)4.37388721
8Abdominal distention (HP:0003270)4.27492060
9Fat malabsorption (HP:0002630)4.03056825
10Abnormality of vitamin B metabolism (HP:0004340)4.02723590
11Hyperactive renin-angiotensin system (HP:0000841)3.98649848
12Abnormality of the vitamin B12 metabolism (HP:0004341)3.93672381
13Micronodular cirrhosis (HP:0001413)3.90644636
14Abnormality of chloride homeostasis (HP:0011422)3.89441999
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76533364
16Woolly hair (HP:0002224)3.72622279
17Atrophic scars (HP:0001075)3.71434543
18Hypobetalipoproteinemia (HP:0003563)3.70974810
19Abnormality of vitamin metabolism (HP:0100508)3.67809064
20Plantar hyperkeratosis (HP:0007556)3.41885522
21Alkalosis (HP:0001948)3.38786666
22Curly hair (HP:0002212)3.37299837
23Chronic diarrhea (HP:0002028)3.36480801
24Intrahepatic cholestasis (HP:0001406)3.35485495
25Flat acetabular roof (HP:0003180)3.35382051
26Rectal prolapse (HP:0002035)3.17355404
27Proximal tubulopathy (HP:0000114)3.17303513
28Hyperglycinuria (HP:0003108)3.08427191
29Abnormal hair laboratory examination (HP:0003328)3.06827611
30Abnormality of the gastric mucosa (HP:0004295)3.00482007
31Confusion (HP:0001289)2.94537856
32Hypoplasia of dental enamel (HP:0006297)2.94028266
33Acanthocytosis (HP:0001927)2.89892416
34Hyponatremia (HP:0002902)2.87982318
35Abnormality of the 1st metacarpal (HP:0010009)2.87921172
36Ventricular fibrillation (HP:0001663)2.84845382
37Malnutrition (HP:0004395)2.79720525
38Dehydration (HP:0001944)2.79198644
39Megaloblastic anemia (HP:0001889)2.74113895
40Hypotension (HP:0002615)2.71669442
41Pustule (HP:0200039)2.69381028
42Vascular calcification (HP:0004934)2.66476174
43Increased purine levels (HP:0004368)2.65803127
44Hyperuricemia (HP:0002149)2.65803127
45Glycosuria (HP:0003076)2.65079421
46Abnormality of urine glucose concentration (HP:0011016)2.65079421
47Abnormal pancreas size (HP:0012094)2.63386847
48Abnormality of glycine metabolism (HP:0010895)2.62026211
49Abnormality of serine family amino acid metabolism (HP:0010894)2.62026211
50Trismus (HP:0000211)2.61428387
51Hypoglycemic seizures (HP:0002173)2.54489941
52Congenital sensorineural hearing impairment (HP:0008527)2.54127569
53Steatorrhea (HP:0002570)2.51823442
54Abnormality of the distal phalanges of the toes (HP:0010182)2.50526600
55Hypoplastic labia majora (HP:0000059)2.49213988
56Hyperammonemia (HP:0001987)2.48188992
57Systemic lupus erythematosus (HP:0002725)2.46724610
58Metabolic alkalosis (HP:0200114)2.44757334
59Lip pit (HP:0100267)2.44583623
60Hyperparathyroidism (HP:0000843)2.42797574
61* Abnormal biliary tract morphology (HP:0012440)2.42795271
62Nail dystrophy (HP:0008404)2.41373585
63Pterygium (HP:0001059)2.40555752
64Hypoplasia of the uterus (HP:0000013)2.39280326
65Microretrognathia (HP:0000308)2.38498639
66Palpitations (HP:0001962)2.38427196
67Wide cranial sutures (HP:0010537)2.34245803
68Pigmentary retinal degeneration (HP:0001146)2.33684389
69Esophageal varix (HP:0002040)2.31241532
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.30527853
71Vertebral hypoplasia (HP:0008417)2.30527853
72Glomerulosclerosis (HP:0000096)2.29527618
73Chronic bronchitis (HP:0004469)2.26203964
74Esophageal atresia (HP:0002032)2.25342902
75Progressive sensorineural hearing impairment (HP:0000408)2.23076805
76Abnormality of the labia majora (HP:0012881)2.21809048
77Congenital ichthyosiform erythroderma (HP:0007431)2.21743004
78Abnormality of magnesium homeostasis (HP:0004921)2.21423435
79Abnormality of the proximal phalanges of the hand (HP:0009834)2.21094352
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20788814
81Abnormality of potassium homeostasis (HP:0011042)2.20766368
82Thin bony cortex (HP:0002753)2.20502913
83Abnormal blistering of the skin (HP:0008066)2.20035282
84Ureteral stenosis (HP:0000071)2.19652759
85Nephrolithiasis (HP:0000787)2.19575363
86Abnormal vertebral ossification (HP:0100569)2.19293139
87Blepharitis (HP:0000498)2.19284261
88Abnormality of purine metabolism (HP:0004352)2.18176470
89Aplasia/hypoplasia of the uterus (HP:0008684)2.18064204
90Cupped ribs (HP:0000887)2.17586978
91Late onset (HP:0003584)2.17063021
92Fragile skin (HP:0001030)2.16882517
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.15443260
94Cardiovascular calcification (HP:0011915)2.15371477
95Subcapsular cataract (HP:0000523)2.15016795
96Hemorrhage of the eye (HP:0011885)2.14813869
97Xanthomatosis (HP:0000991)2.13072566
98Cheilitis (HP:0100825)2.12182285
99Colon cancer (HP:0003003)2.11373344
100Abnormality of the distal phalanx of the thumb (HP:0009617)2.11224274
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10997277
102Renal tubular acidosis (HP:0001947)2.10242176
103Abnormality of sodium homeostasis (HP:0010931)2.10221590
104Ureteral obstruction (HP:0006000)2.09336432
105Conjugated hyperbilirubinemia (HP:0002908)2.09315919
106Abnormality of proline metabolism (HP:0010907)2.08368675
107Hydroxyprolinuria (HP:0003080)2.08368675
108Symptomatic seizures (HP:0011145)2.07894364
109Hyperphosphatemia (HP:0002905)2.07601195
110Symphalangism affecting the phalanges of the hand (HP:0009773)2.06324183
111Hypolipoproteinemia (HP:0010981)2.05895638
112Growth hormone excess (HP:0000845)2.05007798
113Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.03894137
114Hypophosphatemia (HP:0002148)2.03140756
115Abnormality of renin-angiotensin system (HP:0000847)2.02883519
116Hyperphosphaturia (HP:0003109)2.00809866
117Exocrine pancreatic insufficiency (HP:0001738)2.00604909
118Abnormal tarsal ossification (HP:0008369)2.00012706
119Abnormal urine phosphate concentration (HP:0012599)1.99537262
120Hyperaldosteronism (HP:0000859)1.98810606
121Hyperkalemia (HP:0002153)1.97766242
122Abnormal hemoglobin (HP:0011902)1.97572766
123Nausea (HP:0002018)1.97246086
124Abnormal cartilage morphology (HP:0002763)1.96279596
125Abnormality of nucleobase metabolism (HP:0010932)1.96022088
126Hypoglycemic coma (HP:0001325)1.92236417
127Mildly elevated creatine phosphokinase (HP:0008180)1.91549329
128Short phalanx of the thumb (HP:0009660)1.90891285
129Hyperglycemia (HP:0003074)1.90510983
130Hyperinsulinemic hypoglycemia (HP:0000825)1.90427308
131Focal segmental glomerulosclerosis (HP:0000097)1.88480922
132Breast carcinoma (HP:0003002)1.87672878
133Hypokalemia (HP:0002900)1.87349325
134Progressive hearing impairment (HP:0001730)1.86204971
135Stenosis of the external auditory canal (HP:0000402)1.85452339
136Metabolic acidosis (HP:0001942)1.84417475
137Widely patent fontanelles and sutures (HP:0004492)1.84022229
138Syncope (HP:0001279)1.81668193
139Popliteal pterygium (HP:0009756)1.80117814
140Abnormality of carpal bone ossification (HP:0006257)1.79762105
141Glomerulonephritis (HP:0000099)1.79711262
142Unilateral renal agenesis (HP:0000122)1.78217085
143Ventricular tachycardia (HP:0004756)1.77954017
144Posterior subcapsular cataract (HP:0007787)1.77418452
145Goiter (HP:0000853)1.77253646
146Alopecia of scalp (HP:0002293)1.76934658
147Delayed epiphyseal ossification (HP:0002663)1.76921221
148Gout (HP:0001997)1.76836318
14911 pairs of ribs (HP:0000878)1.76542589
150Flattened epiphyses (HP:0003071)1.76534379
151Dicarboxylic aciduria (HP:0003215)1.75705621
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75705621
153Vertebral clefting (HP:0008428)1.75457401
154Protuberant abdomen (HP:0001538)1.75447594
155Amelogenesis imperfecta (HP:0000705)1.75198344
156Aplasia/hypoplasia of the humerus (HP:0006507)1.75034448
157Palmoplantar hyperkeratosis (HP:0000972)1.74799695
158Abnormal glucose tolerance (HP:0001952)1.74069175
159Adrenal overactivity (HP:0002717)1.72605186
160Palmar hyperkeratosis (HP:0010765)1.71835909
161Gastrointestinal dysmotility (HP:0002579)1.71697741
162Abnormal foot bone ossification (HP:0010675)1.70656543
163Ridged nail (HP:0001807)1.69968921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.66380097
2ACVR1B4.55001883
3FRK4.10411740
4MST44.02990220
5LMTK23.63561333
6MST1R3.44350323
7MAP2K22.94054558
8MAP3K122.44673240
9MAP3K22.21377165
10NME12.21353351
11PIK3CA2.18725470
12RPS6KB22.17996436
13TESK12.06727663
14MAPK152.04561101
15LATS11.86481484
16RIPK11.86065478
17STK241.85893530
18FER1.84910430
19EPHB21.74935978
20MET1.68670079
21PTK61.63229805
22STK38L1.59753202
23PRKG21.55632127
24PAK41.46541198
25MAP3K31.43589370
26PTK21.42570900
27PRKCI1.40103000
28TTK1.28885351
29TNIK1.27482684
30SMG11.25531755
31NUAK11.23114787
32AKT31.22756299
33WNK41.22629610
34STK391.12345495
35PASK1.05276461
36SCYL21.00519875
37EPHA30.95640898
38FGFR30.95477941
39AURKB0.95037428
40DDR20.94879835
41WNK30.93961050
42MAPKAPK30.93690380
43BUB10.91046543
44MAP2K10.88832103
45ERN10.88599087
46EPHB10.88300036
47STK100.85654733
48MAP3K80.85191869
49MYLK0.83015513
50ERBB20.79020311
51NEK10.78626207
52EIF2AK10.78388092
53IRAK30.76094385
54LRRK20.70769457
55YES10.70767134
56PBK0.70003647
57NEK60.67674608
58TAOK30.65775992
59MAP2K60.65133298
60NLK0.63122113
61WEE10.62448728
62TAOK10.62395011
63BCR0.61403326
64EEF2K0.60290317
65BMX0.57561436
66MAP3K110.57386486
67MAP3K10.57236359
68DYRK1B0.56341142
69PKN20.55039069
70MATK0.54793486
71CAMK2D0.53217876
72NEK20.52887460
73GRK60.51948787
74FGFR20.51629991
75MAP3K100.51585002
76STK30.51451797
77CASK0.50845913
78LIMK10.49635732
79FGFR40.48957623
80RPS6KA40.48073647
81OXSR10.47753438
82DYRK30.47522501
83BRSK20.46091534
84PDPK10.45994850
85PRKAA20.45434692
86KSR20.44946526
87PIK3CG0.44164695
88CDK60.43841635
89TSSK60.43170290
90DMPK0.42986438
91CHUK0.42921573
92PAK30.40957676
93LATS20.40697077
94MELK0.39979186
95DAPK10.38878963
96INSRR0.38339904
97PDGFRA0.36581850
98PDK20.36324803
99TESK20.36012084
100EIF2AK30.35571687
101MAPKAPK20.32586520
102PAK10.32097516
103ALK0.32055910
104CDC42BPA0.31543133
105ABL20.31120208
106SIK10.30669151
107CSNK1A10.30385826
108FGFR10.29473777
109NME20.29303363
110CAMK2B0.28694174
111CAMK2G0.27388643
112TRIB30.25483275
113CSNK1E0.25220020
114PRKCA0.25171422
115AURKA0.24459055
116HIPK20.23337002
117PDK30.23261791
118PDK40.23261791
119ZAK0.22848558
120CDK120.22706726
121SRPK10.22332552
122GRK10.22174102
123CDK70.21956160
124AKT20.21661219
125PLK10.21549762
126SRC0.21039011
127RET0.20950774
128MTOR0.20774177
129GSK3A0.19993387
130MAPK110.17191933
131MAP3K90.16948384

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.92352799
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.27196775
3Mineral absorption_Homo sapiens_hsa049783.36836625
4Fat digestion and absorption_Homo sapiens_hsa049753.31190433
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.85677069
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.68814885
7Arginine biosynthesis_Homo sapiens_hsa002202.48423300
8Tight junction_Homo sapiens_hsa045302.39970347
9Renin-angiotensin system_Homo sapiens_hsa046142.27576710
10Galactose metabolism_Homo sapiens_hsa000522.03858935
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.00166603
12Fructose and mannose metabolism_Homo sapiens_hsa000511.98513289
13Folate biosynthesis_Homo sapiens_hsa007901.97478531
14Protein digestion and absorption_Homo sapiens_hsa049741.89849399
15Retinol metabolism_Homo sapiens_hsa008301.82305750
16Histidine metabolism_Homo sapiens_hsa003401.79171654
17Adherens junction_Homo sapiens_hsa045201.64390380
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59704456
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59076173
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56314751
21Vibrio cholerae infection_Homo sapiens_hsa051101.54001671
22Glutathione metabolism_Homo sapiens_hsa004801.53673266
23Bladder cancer_Homo sapiens_hsa052191.50965201
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48210231
25Vitamin digestion and absorption_Homo sapiens_hsa049771.45926051
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45123834
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44263576
28Thyroid cancer_Homo sapiens_hsa052161.42898485
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.42728906
30PPAR signaling pathway_Homo sapiens_hsa033201.39787473
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32108961
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.31000061
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28566084
34Ribosome_Homo sapiens_hsa030101.26692626
35Caffeine metabolism_Homo sapiens_hsa002321.24436388
36Pancreatic secretion_Homo sapiens_hsa049721.22268521
37Hippo signaling pathway_Homo sapiens_hsa043901.20746406
38Linoleic acid metabolism_Homo sapiens_hsa005911.20481283
39Thyroid hormone synthesis_Homo sapiens_hsa049181.12654906
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10990559
41Protein export_Homo sapiens_hsa030601.10306023
42Bile secretion_Homo sapiens_hsa049761.09514459
43Nitrogen metabolism_Homo sapiens_hsa009101.06402570
44Sphingolipid metabolism_Homo sapiens_hsa006001.06025733
45N-Glycan biosynthesis_Homo sapiens_hsa005101.02591637
46Sulfur relay system_Homo sapiens_hsa041221.02183922
47Arachidonic acid metabolism_Homo sapiens_hsa005901.01448668
48Selenocompound metabolism_Homo sapiens_hsa004501.00582427
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92764489
50Hepatitis C_Homo sapiens_hsa051600.92147329
51Starch and sucrose metabolism_Homo sapiens_hsa005000.90589522
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89812274
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89411934
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88484754
55Fatty acid metabolism_Homo sapiens_hsa012120.87037546
56Pentose phosphate pathway_Homo sapiens_hsa000300.86254292
57Small cell lung cancer_Homo sapiens_hsa052220.85234459
58ECM-receptor interaction_Homo sapiens_hsa045120.83998610
59Other glycan degradation_Homo sapiens_hsa005110.82438895
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78487667
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.78351000
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78148959
63Glycerolipid metabolism_Homo sapiens_hsa005610.78111474
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75184784
65Proteasome_Homo sapiens_hsa030500.74674740
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71041398
67Tyrosine metabolism_Homo sapiens_hsa003500.68207942
68Arginine and proline metabolism_Homo sapiens_hsa003300.67700312
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66779697
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66063512
71Fatty acid biosynthesis_Homo sapiens_hsa000610.63266316
72Basal cell carcinoma_Homo sapiens_hsa052170.63193180
73Tryptophan metabolism_Homo sapiens_hsa003800.61089611
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59731388
75Peroxisome_Homo sapiens_hsa041460.59480126
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59188940
77Fatty acid degradation_Homo sapiens_hsa000710.59103311
78Fatty acid elongation_Homo sapiens_hsa000620.59042727
79p53 signaling pathway_Homo sapiens_hsa041150.57554220
80Propanoate metabolism_Homo sapiens_hsa006400.57095720
81Phenylalanine metabolism_Homo sapiens_hsa003600.57000277
82Vitamin B6 metabolism_Homo sapiens_hsa007500.55524418
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.54239462
84Endometrial cancer_Homo sapiens_hsa052130.51760331
85Biosynthesis of amino acids_Homo sapiens_hsa012300.50718445
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50584663
87TGF-beta signaling pathway_Homo sapiens_hsa043500.48951934
88Chemical carcinogenesis_Homo sapiens_hsa052040.48654569
89Legionellosis_Homo sapiens_hsa051340.48450560
90Antigen processing and presentation_Homo sapiens_hsa046120.46351145
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44986492
92Butanoate metabolism_Homo sapiens_hsa006500.43780622
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.42241138
94RNA transport_Homo sapiens_hsa030130.41516603
95Proteoglycans in cancer_Homo sapiens_hsa052050.40718831
96Toxoplasmosis_Homo sapiens_hsa051450.38437026
97beta-Alanine metabolism_Homo sapiens_hsa004100.38070677
98Amoebiasis_Homo sapiens_hsa051460.37577640
99Carbon metabolism_Homo sapiens_hsa012000.35272235
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34302706
101Metabolic pathways_Homo sapiens_hsa011000.33749420
102Oxidative phosphorylation_Homo sapiens_hsa001900.33408509
103Salmonella infection_Homo sapiens_hsa051320.32817905
104Insulin resistance_Homo sapiens_hsa049310.32652168
105Pyrimidine metabolism_Homo sapiens_hsa002400.32506489
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32091604
107Glucagon signaling pathway_Homo sapiens_hsa049220.30214854
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28870442
109Pyruvate metabolism_Homo sapiens_hsa006200.28550661
110Hedgehog signaling pathway_Homo sapiens_hsa043400.27745455
111Focal adhesion_Homo sapiens_hsa045100.25797782
112Cysteine and methionine metabolism_Homo sapiens_hsa002700.25212884
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24491121
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24196293
115Prostate cancer_Homo sapiens_hsa052150.23667148
116Ether lipid metabolism_Homo sapiens_hsa005650.23465263
117MicroRNAs in cancer_Homo sapiens_hsa052060.23307021
118Pathways in cancer_Homo sapiens_hsa052000.21352857
119Spliceosome_Homo sapiens_hsa030400.19229296
120Influenza A_Homo sapiens_hsa051640.18416900
121Cell cycle_Homo sapiens_hsa041100.18257474
122Insulin secretion_Homo sapiens_hsa049110.17457570
123Renin secretion_Homo sapiens_hsa049240.17338160
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17275928
125ABC transporters_Homo sapiens_hsa020100.16005896
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.14889123
127AMPK signaling pathway_Homo sapiens_hsa041520.09092383
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.09076012
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09002714
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.01659155
131Type I diabetes mellitus_Homo sapiens_hsa049400.00569014
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.00301956
133Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0200209
134Complement and coagulation cascades_Homo sapiens_hsa04610-0.0166435

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