EPDR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.44883786
2neuronal action potential propagation (GO:0019227)5.43730755
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.22008515
4synaptic vesicle exocytosis (GO:0016079)5.14688483
5glutamate secretion (GO:0014047)4.84419979
6locomotory exploration behavior (GO:0035641)4.71406492
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56856116
8regulation of synaptic vesicle exocytosis (GO:2000300)4.50092015
9vocalization behavior (GO:0071625)4.32881634
10muscle filament sliding (GO:0030049)4.28269330
11actin-myosin filament sliding (GO:0033275)4.28269330
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.17350851
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17255894
14protein localization to synapse (GO:0035418)4.12387877
15regulation of synaptic vesicle transport (GO:1902803)4.10347638
16regulation of cell communication by electrical coupling (GO:0010649)4.07787994
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.07661031
18cellular potassium ion homeostasis (GO:0030007)4.05515155
19neurotransmitter secretion (GO:0007269)4.00154816
20positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.96799826
21regulation of glutamate receptor signaling pathway (GO:1900449)3.93408910
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91679103
23exploration behavior (GO:0035640)3.89622283
24sarcoplasmic reticulum calcium ion transport (GO:0070296)3.88900442
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.88187290
26proline transport (GO:0015824)3.86007833
27regulation of neuronal synaptic plasticity (GO:0048168)3.84189993
28sodium ion export (GO:0071436)3.80535028
29neuron cell-cell adhesion (GO:0007158)3.79174124
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.77701352
31membrane depolarization during action potential (GO:0086010)3.68245976
32regulation of synapse structural plasticity (GO:0051823)3.68239058
33neuromuscular process controlling posture (GO:0050884)3.66696561
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.65390003
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.60686061
36negative regulation of dendrite morphogenesis (GO:0050774)3.59660258
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59529871
38actin-mediated cell contraction (GO:0070252)3.55546480
39glutamate receptor signaling pathway (GO:0007215)3.54458605
40activation of protein kinase A activity (GO:0034199)3.53622395
41cerebellar granule cell differentiation (GO:0021707)3.47159058
42cell communication by electrical coupling (GO:0010644)3.47003783
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46569275
44synaptic transmission, glutamatergic (GO:0035249)3.45599110
45neuron-neuron synaptic transmission (GO:0007270)3.38164097
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.35401184
47layer formation in cerebral cortex (GO:0021819)3.31941967
48neurotransmitter transport (GO:0006836)3.29438916
49regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.29187605
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27520654
51regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27295599
52gamma-aminobutyric acid transport (GO:0015812)3.27053591
53cerebellar Purkinje cell differentiation (GO:0021702)3.24811131
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24717527
55positive regulation of potassium ion transmembrane transport (GO:1901381)3.22115873
56regulation of vesicle fusion (GO:0031338)3.21090635
57cardiac muscle contraction (GO:0060048)3.20209882
58innervation (GO:0060384)3.19489348
59neuromuscular synaptic transmission (GO:0007274)3.19020356
60striated muscle contraction (GO:0006941)3.17967397
61neuromuscular process controlling balance (GO:0050885)3.16396802
62response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.11337146
63regulation of neurotransmitter secretion (GO:0046928)3.09732038
64regulation of synaptic plasticity (GO:0048167)3.09658112
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08775278
66regulation of neurotransmitter levels (GO:0001505)3.08638825
67creatine metabolic process (GO:0006600)3.07274563
68vesicle transport along microtubule (GO:0047496)3.07273788
69potassium ion homeostasis (GO:0055075)3.05807197
70transmission of nerve impulse (GO:0019226)3.05366055
71skeletal muscle contraction (GO:0003009)3.04542218
72positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.04166188
73positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.03921564
74cell migration in hindbrain (GO:0021535)3.03852567
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03834731
76negative regulation of dendrite development (GO:2000171)3.03794739
77regulation of synaptic transmission, glutamatergic (GO:0051966)3.01953139
78long-term memory (GO:0007616)3.01243517
79mating behavior (GO:0007617)3.00017614
80detection of calcium ion (GO:0005513)2.99577261
81amino acid import (GO:0043090)2.98479639
82neurotransmitter-gated ion channel clustering (GO:0072578)2.97936920
83membrane depolarization (GO:0051899)2.97249450
84detection of temperature stimulus involved in sensory perception (GO:0050961)2.96280508
85detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.96280508
86regulation of neurotransmitter transport (GO:0051588)2.94190768
87regulation of synapse maturation (GO:0090128)2.94082075
88detection of temperature stimulus (GO:0016048)2.92971334
89calcium-mediated signaling using intracellular calcium source (GO:0035584)2.92106395
90regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.91662817
91NADH metabolic process (GO:0006734)2.91617609
92regulation of postsynaptic membrane potential (GO:0060078)2.91584107
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91292122
94neuron recognition (GO:0008038)2.91248892
95positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90135062
96neuronal action potential (GO:0019228)2.89651730
97gamma-aminobutyric acid signaling pathway (GO:0007214)2.88735645
98potassium ion import (GO:0010107)2.88119385
99positive regulation of potassium ion transport (GO:0043268)2.88040964
100regulation of skeletal muscle contraction (GO:0014819)2.87657275
101neurofilament cytoskeleton organization (GO:0060052)2.86847572
102synaptic vesicle endocytosis (GO:0048488)2.86783695
103membrane repolarization (GO:0086009)2.86186599
104response to muscle activity (GO:0014850)2.85435417
105synaptic transmission (GO:0007268)2.85024074
106long-term synaptic potentiation (GO:0060291)2.84565490
107regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.84222102
108positive regulation of membrane potential (GO:0045838)2.83712300
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.83230514
110L-amino acid import (GO:0043092)2.81632970
111skeletal muscle fiber development (GO:0048741)2.81046253
112regulation of actin filament-based movement (GO:1903115)2.80457035
113regulation of glutamate secretion (GO:0014048)2.79878658
114regulation of calcium ion transmembrane transporter activity (GO:1901019)2.79435223
115regulation of calcium ion transmembrane transport (GO:1903169)2.79435223
116axon cargo transport (GO:0008088)2.78993033
117neuromuscular process (GO:0050905)2.78899431
118regulation of voltage-gated calcium channel activity (GO:1901385)2.78550858
119calcium ion-dependent exocytosis (GO:0017156)2.77893223
120peptidyl-proline hydroxylation (GO:0019511)2.77767231
121cellular sodium ion homeostasis (GO:0006883)2.77636192
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.76156160
123organelle transport along microtubule (GO:0072384)2.75889908
124positive regulation of synapse maturation (GO:0090129)2.75518797
125plasma membrane repair (GO:0001778)2.75442707
126axonal fasciculation (GO:0007413)2.74895578
127regulation of relaxation of muscle (GO:1901077)2.74419166
128protein hydroxylation (GO:0018126)2.71175254
129protein retention in ER lumen (GO:0006621)2.66843482
130myofibril assembly (GO:0030239)2.65594461
131positive regulation of dendritic spine development (GO:0060999)2.64317293
132postsynaptic membrane organization (GO:0001941)2.61430232
133positive regulation of dendritic spine morphogenesis (GO:0061003)2.60531573
134dicarboxylic acid biosynthetic process (GO:0043650)2.60078293
135actin filament-based movement (GO:0030048)2.59433157
136daunorubicin metabolic process (GO:0044597)2.58525890
137polyketide metabolic process (GO:0030638)2.58525890
138doxorubicin metabolic process (GO:0044598)2.58525890
139neurotransmitter uptake (GO:0001504)2.56950340
140negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.56793039
141negative regulation of calcium ion transmembrane transport (GO:1903170)2.56793039
142cardiac myofibril assembly (GO:0055003)2.55382171
143negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.52590674
144gluconeogenesis (GO:0006094)2.51575432
145cell communication involved in cardiac conduction (GO:0086065)2.51366099
146regulation of sodium ion transmembrane transport (GO:1902305)2.50327226
147regulation of sodium ion transmembrane transporter activity (GO:2000649)2.50079572
148maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49351774
149muscle cell cellular homeostasis (GO:0046716)2.49255509
150phosphate ion transmembrane transport (GO:0035435)2.47548658
151regulation of dendritic spine morphogenesis (GO:0061001)2.46737728
152muscle contraction (GO:0006936)2.45323918
153neuronal ion channel clustering (GO:0045161)2.45168839
154relaxation of muscle (GO:0090075)2.40666658
155sarcomere organization (GO:0045214)2.39865481
156myotube cell development (GO:0014904)2.39490887
157negative regulation of protein localization to cell surface (GO:2000009)2.36721050
158axon ensheathment in central nervous system (GO:0032291)2.36711846
159central nervous system myelination (GO:0022010)2.36711846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75927425
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.10398553
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.43029207
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.32261895
5GBX2_23144817_ChIP-Seq_PC3_Human3.25273015
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23438352
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.96341098
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.96341098
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.95554662
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.84512184
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.84442956
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79825829
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.75775693
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72641764
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66222604
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.59975376
17REST_21632747_ChIP-Seq_MESCs_Mouse2.58986783
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55716770
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.52715653
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.52481080
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.44600209
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.40826982
23CLOCK_20551151_ChIP-Seq_293T_Human2.32615059
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.24820219
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24002091
26DROSHA_22980978_ChIP-Seq_HELA_Human2.22365708
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.22086699
28AR_21572438_ChIP-Seq_LNCaP_Human2.18595524
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.15877182
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98660670
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95700154
32ZNF263_19887448_ChIP-Seq_K562_Human1.94948324
33ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.86267778
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85788219
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.82745292
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81366284
37ZNF274_21170338_ChIP-Seq_K562_Hela1.75713708
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.71681538
39TAF15_26573619_Chip-Seq_HEK293_Human1.71289009
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66922190
41TBX20_22328084_ChIP-Seq_HEART_Mouse1.65999401
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.65999401
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65767971
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65153820
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61624495
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59656005
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.58330074
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56216352
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56104581
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55579957
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46691343
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.40191053
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.39080677
54LXR_22292898_ChIP-Seq_THP-1_Human1.35768731
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34473844
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33245222
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.33134894
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32993116
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29713925
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27547418
61P300_19829295_ChIP-Seq_ESCs_Human1.27430356
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27227147
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26429365
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.26048858
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24870308
66AR_25329375_ChIP-Seq_VCAP_Human1.24322907
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23393866
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22227596
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21561304
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20600986
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19694820
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19678029
73* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19554360
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.19149839
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.18914168
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17784679
77* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17069187
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16702942
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16338455
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16185574
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12844275
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.11711199
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11441434
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.11273351
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11196596
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11196596
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10442648
88AR_19668381_ChIP-Seq_PC3_Human1.09793080
89ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09543383
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09104726
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08723344
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07899594
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.07587346
94EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06297551
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06182820
96IGF1R_20145208_ChIP-Seq_DFB_Human1.05460954
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.04366618
98STAT3_23295773_ChIP-Seq_U87_Human1.03795310
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02999329
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02928236
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01849401
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01219788
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.00967965
104KDM2B_26808549_Chip-Seq_K562_Human1.00472989
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98268811
106JUN_21703547_ChIP-Seq_K562_Human0.98175339
107CBX2_27304074_Chip-Seq_ESCs_Mouse0.98151836
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.97818465
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97433671
110SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97151381
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.96636832
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96397646
113BCAT_22108803_ChIP-Seq_LS180_Human0.96167802
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.95959366
115CTCF_27219007_Chip-Seq_Bcells_Human0.95452513
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94989324
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94770805
118TET1_21490601_ChIP-Seq_MESCs_Mouse0.94044292
119YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93259881
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92843223
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92275612
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92259841
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92214394
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91443232
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91355390
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.90626637
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90496954
128TP53_18474530_ChIP-ChIP_U2OS_Human0.90218088
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89754679
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89676406
131TP53_16413492_ChIP-PET_HCT116_Human0.87605427
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.87573232
133TCF4_23295773_ChIP-Seq_U87_Human0.87238491
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86546500
135MYC_19915707_ChIP-ChIP_AK7_Human0.86431978
136PRDM14_20953172_ChIP-Seq_ESCs_Human0.86188375
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85529260
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.85189803
139SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84985543
140RUNX2_22187159_ChIP-Seq_PCA_Human0.84075537
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84061497
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83848738
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.83659016
144RXR_22108803_ChIP-Seq_LS180_Human0.83612736
145P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83476478
146RNF2_27304074_Chip-Seq_NSC_Mouse0.83389562
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81782020
148GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81484157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.44025756
2MP0003880_abnormal_central_pattern4.08404433
3MP0004270_analgesia3.83280195
4MP0001968_abnormal_touch/_nociception3.80266269
5MP0003635_abnormal_synaptic_transmissio3.57061399
6MP0002735_abnormal_chemical_nociception3.30900802
7MP0002736_abnormal_nociception_after3.18262945
8MP0009745_abnormal_behavioral_response2.99547851
9MP0009046_muscle_twitch2.96418472
10MP0002734_abnormal_mechanical_nocicepti2.83385374
11MP0002064_seizures2.81877131
12MP0008438_abnormal_cutaneous_collagen2.80818032
13MP0002063_abnormal_learning/memory/cond2.72531085
14MP0004858_abnormal_nervous_system2.58632003
15MP0002272_abnormal_nervous_system2.58568507
16MP0002733_abnormal_thermal_nociception2.48864080
17MP0006276_abnormal_autonomic_nervous2.40162061
18MP0002572_abnormal_emotion/affect_behav2.35337273
19MP0002822_catalepsy2.34276910
20MP0000751_myopathy2.33332830
21MP0001970_abnormal_pain_threshold2.28074162
22MP0005423_abnormal_somatic_nervous2.09736484
23MP0003329_amyloid_beta_deposits2.07492546
24MP0004145_abnormal_muscle_electrophysio2.04350255
25MP0002067_abnormal_sensory_capabilities2.03864408
26MP0001440_abnormal_grooming_behavior2.03330686
27MP0001486_abnormal_startle_reflex1.99685656
28MP0001501_abnormal_sleep_pattern1.87865298
29MP0008569_lethality_at_weaning1.85913721
30MP0004084_abnormal_cardiac_muscle1.82554516
31MP0002184_abnormal_innervation1.80552394
32MP0002909_abnormal_adrenal_gland1.62307053
33MP0004811_abnormal_neuron_physiology1.60510338
34MP0003122_maternal_imprinting1.54889000
35MP0002837_dystrophic_cardiac_calcinosis1.53777699
36MP0005386_behavior/neurological_phenoty1.53629115
37MP0004924_abnormal_behavior1.53629115
38MP0000955_abnormal_spinal_cord1.53566519
39MP0005330_cardiomyopathy1.51931734
40MP0004142_abnormal_muscle_tone1.49981405
41MP0002557_abnormal_social/conspecific_i1.48908809
42MP0004272_abnormal_basement_membrane1.48889063
43MP0000003_abnormal_adipose_tissue1.48432739
44MP0001958_emphysema1.48270274
45MP0000749_muscle_degeneration1.48094230
46MP0009780_abnormal_chondrocyte_physiolo1.40059441
47MP0000747_muscle_weakness1.39626252
48MP0001984_abnormal_olfaction1.38734231
49MP0005646_abnormal_pituitary_gland1.36734122
50MP0003690_abnormal_glial_cell1.33798163
51MP0001905_abnormal_dopamine_level1.33570294
52MP0000750_abnormal_muscle_regeneration1.33065487
53MP0002066_abnormal_motor_capabilities/c1.29492849
54MP0003633_abnormal_nervous_system1.26700114
55MP0005451_abnormal_body_composition1.26679465
56MP0002882_abnormal_neuron_morphology1.26660330
57MP0002972_abnormal_cardiac_muscle1.25737860
58MP0000778_abnormal_nervous_system1.22798888
59MP0003646_muscle_fatigue1.21617747
60MP0000013_abnormal_adipose_tissue1.21416079
61MP0001529_abnormal_vocalization1.20686803
62MP0004215_abnormal_myocardial_fiber1.19317579
63MP0003656_abnormal_erythrocyte_physiolo1.18931807
64MP0005645_abnormal_hypothalamus_physiol1.17610444
65MP0003950_abnormal_plasma_membrane1.16925302
66MP0002332_abnormal_exercise_endurance1.15457302
67MP0003705_abnormal_hypodermis_morpholog1.12589553
68MP0005623_abnormal_meninges_morphology1.09994930
69MP0004036_abnormal_muscle_relaxation1.09550557
70MP0003631_nervous_system_phenotype1.06888570
71MP0005165_increased_susceptibility_to1.06551806
72MP0000733_abnormal_muscle_development1.05806945
73MP0010368_abnormal_lymphatic_system1.05422735
74MP0003879_abnormal_hair_cell1.04956669
75MP0002971_abnormal_brown_adipose1.03747783
76MP0001299_abnormal_eye_distance/1.00639955
77MP0001177_atelectasis1.00502179
78MP0002877_abnormal_melanocyte_morpholog0.99613736
79MP0005670_abnormal_white_adipose0.99380139
80MP0001502_abnormal_circadian_rhythm0.99234816
81MP0004147_increased_porphyrin_level0.98985087
82MP0003279_aneurysm0.98350284
83MP0005375_adipose_tissue_phenotype0.97203715
84MP0004885_abnormal_endolymph0.96667588
85MP0002896_abnormal_bone_mineralization0.96116825
86MP0004233_abnormal_muscle_weight0.95771619
87MP0006138_congestive_heart_failure0.95176841
88MP0010630_abnormal_cardiac_muscle0.92889810
89MP0003634_abnormal_glial_cell0.90934995
90MP0000604_amyloidosis0.89661086
91MP0009384_cardiac_valve_regurgitation0.87981843
92MP0005058_abnormal_lysosome_morphology0.87811294
93MP0002229_neurodegeneration0.87765262
94MP0008872_abnormal_physiological_respon0.87708481
95MP0005275_abnormal_skin_tensile0.84986430
96MP0004484_altered_response_of0.84940913
97MP0000759_abnormal_skeletal_muscle0.84848268
98MP0001188_hyperpigmentation0.84436317
99MP0002152_abnormal_brain_morphology0.83468010
100MP0005666_abnormal_adipose_tissue0.82263330
101MP0004085_abnormal_heartbeat0.81492058
102MP0001542_abnormal_bone_strength0.81443156
103MP0003137_abnormal_impulse_conducting0.81355896
104MP0008874_decreased_physiological_sensi0.81072982
105MP0005620_abnormal_muscle_contractility0.80434607
106MP0006036_abnormal_mitochondrial_physio0.79512068
107MP0001986_abnormal_taste_sensitivity0.79220395
108MP0003191_abnormal_cellular_cholesterol0.78397365
109MP0002269_muscular_atrophy0.77910738
110MP0010386_abnormal_urinary_bladder0.77147294
111MP0004510_myositis0.76347134
112MP0000920_abnormal_myelination0.75877010
113MP0001544_abnormal_cardiovascular_syste0.75682681
114MP0005385_cardiovascular_system_phenoty0.75682681
115MP0005369_muscle_phenotype0.73394757
116MP0002069_abnormal_eating/drinking_beha0.72732446
117MP0001348_abnormal_lacrimal_gland0.72656528
118MP0003632_abnormal_nervous_system0.71746884
119MP0002108_abnormal_muscle_morphology0.70652325
120MP0002106_abnormal_muscle_physiology0.70280312
121MP0004130_abnormal_muscle_cell0.69600298
122MP0002752_abnormal_somatic_nervous0.68298930
123MP0003075_altered_response_to0.68089840
124MP0005171_absent_coat_pigmentation0.67526197
125MP0001963_abnormal_hearing_physiology0.66680361
126MP0005503_abnormal_tendon_morphology0.64111119
127MP0005535_abnormal_body_temperature0.63798443
128MP0000534_abnormal_ureter_morphology0.62876895
129MP0001664_abnormal_digestion0.61603650
130MP0002751_abnormal_autonomic_nervous0.61424151
131MP0004087_abnormal_muscle_fiber0.61071824
132MP0003283_abnormal_digestive_organ0.61070039
133MP0003787_abnormal_imprinting0.60993412
134MP0008961_abnormal_basal_metabolism0.59781573
135MP0002638_abnormal_pupillary_reflex0.59151643
136MP0001485_abnormal_pinna_reflex0.57970104

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.72730131
2Focal motor seizures (HP:0011153)6.60163293
3Focal seizures (HP:0007359)4.97143408
4Atonic seizures (HP:0010819)4.61547276
5Visual hallucinations (HP:0002367)4.33648791
6Action tremor (HP:0002345)4.32820194
7Febrile seizures (HP:0002373)4.00088251
8Epileptic encephalopathy (HP:0200134)3.78740759
9Absence seizures (HP:0002121)3.77755420
10Pheochromocytoma (HP:0002666)3.56989126
11Progressive cerebellar ataxia (HP:0002073)3.55482997
12Round ear (HP:0100830)3.51009757
13Generalized tonic-clonic seizures (HP:0002069)3.48714124
14Dialeptic seizures (HP:0011146)3.41865055
15Protrusio acetabuli (HP:0003179)3.39164838
16Supranuclear gaze palsy (HP:0000605)3.28703146
17Neuroendocrine neoplasm (HP:0100634)3.28178577
18Myoglobinuria (HP:0002913)3.18699457
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.16140043
20Ankle clonus (HP:0011448)3.12315155
21Myotonia (HP:0002486)3.10425774
22Neck muscle weakness (HP:0000467)3.04104849
23Rhabdomyolysis (HP:0003201)3.02906759
24Sudden death (HP:0001699)2.99040989
25Ulnar claw (HP:0001178)2.98178131
26Exercise-induced myalgia (HP:0003738)2.97947377
27Depression (HP:0000716)2.92799561
28Insidious onset (HP:0003587)2.87696596
29Termporal pattern (HP:0011008)2.87696596
30Ulnar deviation of the wrist (HP:0003049)2.86527672
31Truncal ataxia (HP:0002078)2.85980476
32Anxiety (HP:0000739)2.85843616
33Muscle fiber splitting (HP:0003555)2.77129388
34Myopathic facies (HP:0002058)2.76732447
35Impaired vibration sensation in the lower limbs (HP:0002166)2.71109639
36Asymmetric septal hypertrophy (HP:0001670)2.58701494
37Urinary urgency (HP:0000012)2.57225359
38Increased connective tissue (HP:0009025)2.53902368
39Difficulty running (HP:0009046)2.53184401
40Arterial tortuosity (HP:0005116)2.53094141
41Distal lower limb muscle weakness (HP:0009053)2.52464385
42Dysdiadochokinesis (HP:0002075)2.52394529
43Neoplasm of the peripheral nervous system (HP:0100007)2.49524394
44Distal arthrogryposis (HP:0005684)2.48405080
45Abnormal eating behavior (HP:0100738)2.46300050
46Dysmetria (HP:0001310)2.45534494
47Vertebral compression fractures (HP:0002953)2.44532635
48Hypoventilation (HP:0002791)2.42097942
49Vascular tortuosity (HP:0004948)2.41634652
50Amblyopia (HP:0000646)2.41446030
51Gaze-evoked nystagmus (HP:0000640)2.38925790
52Impaired pain sensation (HP:0007328)2.37827440
53Abnormality of pain sensation (HP:0010832)2.37827440
54Poor eye contact (HP:0000817)2.37149766
55Calcaneovalgus deformity (HP:0001848)2.37089528
56Ventricular fibrillation (HP:0001663)2.36758110
57Urinary bladder sphincter dysfunction (HP:0002839)2.31721811
58Broad-based gait (HP:0002136)2.29341802
59Postural instability (HP:0002172)2.29338201
60Progressive inability to walk (HP:0002505)2.26881165
61Scanning speech (HP:0002168)2.25628505
62Abnormality of the left ventricular outflow tract (HP:0011103)2.25061476
63Subaortic stenosis (HP:0001682)2.25061476
64Increased variability in muscle fiber diameter (HP:0003557)2.24117599
65Exercise-induced muscle cramps (HP:0003710)2.23803663
66Megalencephaly (HP:0001355)2.22885964
67Muscle stiffness (HP:0003552)2.22864911
68Absent phalangeal crease (HP:0006109)2.19629643
69Fetal akinesia sequence (HP:0001989)2.19534711
70Abnormal atrioventricular conduction (HP:0005150)2.18695296
71Back pain (HP:0003418)2.18671994
72Muscle fiber inclusion bodies (HP:0100299)2.18647438
73Impaired social interactions (HP:0000735)2.18427414
74Abnormal social behavior (HP:0012433)2.18427414
75Failure to thrive in infancy (HP:0001531)2.17810034
76Akinesia (HP:0002304)2.16713837
77Bradykinesia (HP:0002067)2.13581621
78Torticollis (HP:0000473)2.13402260
79Heart block (HP:0012722)2.12798341
80Frequent falls (HP:0002359)2.11985399
81Delusions (HP:0000746)2.11373152
82Malignant hyperthermia (HP:0002047)2.10923421
83Muscle hypertrophy of the lower extremities (HP:0008968)2.10907918
84Hypercortisolism (HP:0001578)2.10619482
85Type 1 muscle fiber predominance (HP:0003803)2.09616627
86Spastic gait (HP:0002064)2.09565752
87Gowers sign (HP:0003391)2.07989391
88Spinal rigidity (HP:0003306)2.07938742
89Hammertoe (HP:0001765)2.07762046
90Deformed tarsal bones (HP:0008119)2.07126690
91Mildly elevated creatine phosphokinase (HP:0008180)2.06991331
92Scapular winging (HP:0003691)2.06704063
93Abnormality of binocular vision (HP:0011514)2.06060412
94Diplopia (HP:0000651)2.06060412
95Menstrual irregularities (HP:0000858)2.05842058
96Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05041002
97Lower limb muscle weakness (HP:0007340)2.01876870
98Focal dystonia (HP:0004373)2.01366706
99Limb dystonia (HP:0002451)2.01360190
100Rimmed vacuoles (HP:0003805)2.01338641
101Distal lower limb amyotrophy (HP:0008944)2.01001861
102Papilledema (HP:0001085)1.99507408
103Foot dorsiflexor weakness (HP:0009027)1.98976172
104Mitral stenosis (HP:0001718)1.98572966
105Rapidly progressive (HP:0003678)1.98546925
106Retinal dysplasia (HP:0007973)1.98353552
107Atrioventricular block (HP:0001678)1.97433527
108Breech presentation (HP:0001623)1.95977969
109Premature rupture of membranes (HP:0001788)1.95571843
110Calf muscle hypertrophy (HP:0008981)1.93592219
111Abnormality of the lower motor neuron (HP:0002366)1.93573215
112Abnormality of skeletal muscle fiber size (HP:0012084)1.93497627
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91564121
114Rigidity (HP:0002063)1.91560136
115EMG: neuropathic changes (HP:0003445)1.91106381
116Insomnia (HP:0100785)1.90343785
117Steppage gait (HP:0003376)1.90162973
118Hemiparesis (HP:0001269)1.89486577
119Nemaline bodies (HP:0003798)1.88685016
120Abnormality of glycolysis (HP:0004366)1.87870300
121Bundle branch block (HP:0011710)1.87687274
122Mutism (HP:0002300)1.87365053
123Abnormality of the calf musculature (HP:0001430)1.87211580
124Wormian bones (HP:0002645)1.86697085
125Craniofacial dystonia (HP:0012179)1.85678044
126Type II lissencephaly (HP:0007260)1.85384414
127Limb-girdle muscle atrophy (HP:0003797)1.85159027
128Deep venous thrombosis (HP:0002625)1.85018770
129Aplasia involving bones of the extremities (HP:0009825)1.84238633
130Aplasia involving bones of the upper limbs (HP:0009823)1.84238633
131Aplasia of the phalanges of the hand (HP:0009802)1.84238633
132Hyporeflexia of lower limbs (HP:0002600)1.83769274
133Shoulder girdle muscle weakness (HP:0003547)1.83612013
134Neurofibrillary tangles (HP:0002185)1.82596760
135Abnormality of the foot musculature (HP:0001436)1.82560658
136Postural tremor (HP:0002174)1.81665442
137Resting tremor (HP:0002322)1.81575685
138Psychosis (HP:0000709)1.81179396
139Narrow nasal bridge (HP:0000446)1.81058617
140Cerebral inclusion bodies (HP:0100314)1.80604089
141Impaired smooth pursuit (HP:0007772)1.80440895
142Hemiplegia (HP:0002301)1.79716704
143Intention tremor (HP:0002080)1.79647907
144EMG: myopathic abnormalities (HP:0003458)1.78224708
145Abnormality of the corticospinal tract (HP:0002492)1.78056020
146Lower limb amyotrophy (HP:0007210)1.77694098
147Cerebral aneurysm (HP:0004944)1.76501136
148Aortic aneurysm (HP:0004942)1.75623967
149Increased serum pyruvate (HP:0003542)1.73728435
150Tetraplegia (HP:0002445)1.69990587
151Aortic dissection (HP:0002647)1.69625747
152Areflexia of lower limbs (HP:0002522)1.67804531
153Metatarsus adductus (HP:0001840)1.66016230
154Abnormal finger flexion creases (HP:0006143)1.63771295
155Lipoatrophy (HP:0100578)1.62164916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.67465349
2MAP3K93.71151689
3EPHA43.10650419
4MINK12.98827655
5MAP3K122.70927233
6KSR22.70627754
7MAP3K42.68036950
8NTRK12.62060857
9MAP2K42.26531283
10PHKG22.25298839
11PHKG12.25298839
12PAK62.22502785
13MAP2K72.20691466
14ARAF2.17015299
15LMTK22.11725724
16RIPK12.05417056
17TESK11.84319807
18DAPK21.75600054
19RIPK41.69946844
20PRKD31.65052740
21GRK51.63872911
22CAMKK11.57218022
23LATS21.54030961
24NTRK21.45992032
25CASK1.45063381
26CAMKK21.41770914
27MARK11.40944184
28CDK191.38384053
29KSR11.37540067
30PDGFRA1.36397745
31CDK51.36386369
32PLK21.35679329
33MAP3K21.27610374
34NEK91.25968607
35RET1.21292726
36PRKCG1.17224752
37MAP3K131.16698894
38PINK11.12794288
39RAF11.11370652
40CCNB11.10492514
41NME11.09872823
42NEK11.09523906
43BCKDK1.09438179
44SCYL21.07685745
45DAPK11.04155204
46TNIK1.01989361
47MAPK130.99817100
48UHMK10.98084217
49PAK20.96586218
50PNCK0.96397685
51OBSCN0.95576721
52CAMK2A0.95365022
53PAK30.94588871
54STK380.94559080
55LIMK10.93632690
56ICK0.93394835
57CDK140.92937112
58PTK2B0.91661915
59FER0.89093837
60PIM20.89027866
61DAPK30.88399567
62MAP3K10.88375905
63MAPKAPK50.88331061
64CDK180.86134213
65MUSK0.85459006
66CDK150.84451676
67SGK2230.81762677
68SGK4940.81762677
69MAP2K10.81413200
70CAMK2G0.80026754
71MST1R0.78180193
72WNK10.77243594
73PKN10.76856227
74ERN10.74939806
75TNK20.74622331
76CDK11A0.74344404
77ABL20.72562314
78MET0.72474567
79CAMK10.71907146
80AKT20.70307905
81MAPK110.69707412
82CAMK2B0.69392753
83DDR20.68714770
84TAOK10.67079962
85ERBB40.66783463
86PRPF4B0.66434723
87PRKCH0.65740155
88TAOK20.65225298
89TYRO30.63676275
90MOS0.62944841
91MYLK0.62865384
92MAPK100.62842819
93FES0.62281772
94ADRBK10.61117683
95PDPK10.58746540
96CAMK2D0.58442167
97PTK20.58056618
98GRK70.56523753
99SGK20.56521713
100MARK20.56304238
101ROCK20.55900437
102PDK10.55434559
103DMPK0.52587221
104TRIB30.52560044
105TTN0.51383419
106CSNK1G20.49255437
107CDK80.47902084
108SIK20.47466628
109MAPK40.47352280
110TGFBR20.47217766
111BRAF0.46793892
112PRKCE0.46298521
113SGK10.46031315
114PDK40.45714116
115PDK30.45714116
116MAP3K70.45632672
117FGFR40.45595463
118OXSR10.45261119
119CAMK40.44917229
120MATK0.44408489
121SGK30.42356896
122EEF2K0.42108983
123MAPKAPK30.40599469
124RPS6KA30.39073761
125STK110.38558043
126ROCK10.38540419
127MAPK120.38173994
128RPS6KA20.37815570
129MAP3K110.36916347
130PIK3CG0.35980755
131PRKG10.35247223

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.32337282
2Nicotine addiction_Homo sapiens_hsa050333.13522530
3Olfactory transduction_Homo sapiens_hsa047402.63852318
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.56447438
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50154398
6Long-term potentiation_Homo sapiens_hsa047202.45476051
7Circadian entrainment_Homo sapiens_hsa047132.45295568
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.43267085
9GABAergic synapse_Homo sapiens_hsa047272.36526714
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35295338
11Glutamatergic synapse_Homo sapiens_hsa047242.22406050
12Amphetamine addiction_Homo sapiens_hsa050312.21696152
13Salivary secretion_Homo sapiens_hsa049702.07531568
14Dopaminergic synapse_Homo sapiens_hsa047282.05827194
15Morphine addiction_Homo sapiens_hsa050322.05352205
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02437512
17Insulin secretion_Homo sapiens_hsa049111.97662170
18Gastric acid secretion_Homo sapiens_hsa049711.91312848
19Vitamin B6 metabolism_Homo sapiens_hsa007501.87052084
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79082821
21Cholinergic synapse_Homo sapiens_hsa047251.76459070
22Cardiac muscle contraction_Homo sapiens_hsa042601.72095422
23Taste transduction_Homo sapiens_hsa047421.70475426
24Calcium signaling pathway_Homo sapiens_hsa040201.67901451
25Long-term depression_Homo sapiens_hsa047301.66667051
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65608278
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64915492
28Oxytocin signaling pathway_Homo sapiens_hsa049211.63872629
29Arginine and proline metabolism_Homo sapiens_hsa003301.63776607
30Collecting duct acid secretion_Homo sapiens_hsa049661.63515750
31Carbon metabolism_Homo sapiens_hsa012001.59646352
32Renin secretion_Homo sapiens_hsa049241.54651926
33Serotonergic synapse_Homo sapiens_hsa047261.53164084
34GnRH signaling pathway_Homo sapiens_hsa049121.50201131
35Biosynthesis of amino acids_Homo sapiens_hsa012301.40794532
36Cocaine addiction_Homo sapiens_hsa050301.39372850
37Gap junction_Homo sapiens_hsa045401.38740643
38Pentose phosphate pathway_Homo sapiens_hsa000301.37593546
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34903213
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34689410
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33673963
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32971900
43Fructose and mannose metabolism_Homo sapiens_hsa000511.25365724
44ECM-receptor interaction_Homo sapiens_hsa045121.25151570
45Oxidative phosphorylation_Homo sapiens_hsa001901.24666259
46Phenylalanine metabolism_Homo sapiens_hsa003601.21994701
47Fatty acid metabolism_Homo sapiens_hsa012121.21904415
48Pyruvate metabolism_Homo sapiens_hsa006201.20361055
49Parkinsons disease_Homo sapiens_hsa050121.20297604
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20273338
51Arginine biosynthesis_Homo sapiens_hsa002201.18534161
52Vibrio cholerae infection_Homo sapiens_hsa051101.17950994
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.16711969
54Glioma_Homo sapiens_hsa052141.14982459
55cAMP signaling pathway_Homo sapiens_hsa040241.12584922
56Alzheimers disease_Homo sapiens_hsa050101.11783631
57Melanogenesis_Homo sapiens_hsa049161.11281966
58Estrogen signaling pathway_Homo sapiens_hsa049151.08193741
59Dilated cardiomyopathy_Homo sapiens_hsa054141.06166213
60Fatty acid degradation_Homo sapiens_hsa000711.04105799
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.03190962
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02845726
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98530871
64Histidine metabolism_Homo sapiens_hsa003400.96085942
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95587404
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95241954
67Fatty acid elongation_Homo sapiens_hsa000620.94698634
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.93322023
69PPAR signaling pathway_Homo sapiens_hsa033200.92400683
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92284679
71Oocyte meiosis_Homo sapiens_hsa041140.91550072
72Dorso-ventral axis formation_Homo sapiens_hsa043200.88779542
73Focal adhesion_Homo sapiens_hsa045100.87803609
74ErbB signaling pathway_Homo sapiens_hsa040120.87439806
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.81977354
76Thyroid hormone synthesis_Homo sapiens_hsa049180.80652033
77Pancreatic secretion_Homo sapiens_hsa049720.79089722
78Glucagon signaling pathway_Homo sapiens_hsa049220.77512832
79Axon guidance_Homo sapiens_hsa043600.77432012
80AMPK signaling pathway_Homo sapiens_hsa041520.76262853
81Nitrogen metabolism_Homo sapiens_hsa009100.75545419
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75268796
83Type II diabetes mellitus_Homo sapiens_hsa049300.75195761
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.74580984
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73246583
86beta-Alanine metabolism_Homo sapiens_hsa004100.73194137
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72288412
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70805442
89Fatty acid biosynthesis_Homo sapiens_hsa000610.70065467
90Huntingtons disease_Homo sapiens_hsa050160.69640175
91Complement and coagulation cascades_Homo sapiens_hsa046100.69592048
92Galactose metabolism_Homo sapiens_hsa000520.68950612
93VEGF signaling pathway_Homo sapiens_hsa043700.68064993
94Tyrosine metabolism_Homo sapiens_hsa003500.67124527
95Insulin signaling pathway_Homo sapiens_hsa049100.65119739
96MAPK signaling pathway_Homo sapiens_hsa040100.64372922
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61902755
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60867590
99Choline metabolism in cancer_Homo sapiens_hsa052310.60605147
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59360505
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.58930492
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57124265
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.56742404
104Propanoate metabolism_Homo sapiens_hsa006400.55734911
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.54423331
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54007502
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50478357
108Rap1 signaling pathway_Homo sapiens_hsa040150.49208161
109Starch and sucrose metabolism_Homo sapiens_hsa005000.49148630
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48347143
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.48113218
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48111036
113Bile secretion_Homo sapiens_hsa049760.47718450
114Ras signaling pathway_Homo sapiens_hsa040140.47239824
115Folate biosynthesis_Homo sapiens_hsa007900.45926394
116Endocytosis_Homo sapiens_hsa041440.44918433
117Alcoholism_Homo sapiens_hsa050340.43811359
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42233226
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40727901
120Prion diseases_Homo sapiens_hsa050200.39652926
121mTOR signaling pathway_Homo sapiens_hsa041500.39372857
122Circadian rhythm_Homo sapiens_hsa047100.39332366
123Wnt signaling pathway_Homo sapiens_hsa043100.37571066
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35865735
125Melanoma_Homo sapiens_hsa052180.35751132
126Phototransduction_Homo sapiens_hsa047440.35617596
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35492990
128Proteoglycans in cancer_Homo sapiens_hsa052050.35183957
129Non-small cell lung cancer_Homo sapiens_hsa052230.33968791
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33683514
131Endometrial cancer_Homo sapiens_hsa052130.33149662
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32730710
133Ovarian steroidogenesis_Homo sapiens_hsa049130.32282137
134Thyroid cancer_Homo sapiens_hsa052160.32135258
135Inositol phosphate metabolism_Homo sapiens_hsa005620.31303399
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29001327
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28430396
138Renal cell carcinoma_Homo sapiens_hsa052110.25825407
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24948070
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24613189

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