EPG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large coiled coil domain-containing protein that functions in autophagy during starvation conditions. Mutations in this gene cause Vici syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dicarboxylic acid biosynthetic process (GO:0043650)4.06851298
2urea metabolic process (GO:0019627)3.97433874
3urea cycle (GO:0000050)3.97433874
4cell adhesion mediated by integrin (GO:0033627)3.84784372
5phospholipid homeostasis (GO:0055091)3.78239340
6cytoplasmic mRNA processing body assembly (GO:0033962)3.75465328
7alpha-linolenic acid metabolic process (GO:0036109)3.66474618
8nitrogen cycle metabolic process (GO:0071941)3.57471907
9skin morphogenesis (GO:0043589)3.39315352
10regulation of cholesterol homeostasis (GO:2000188)3.30456689
11macroautophagy (GO:0016236)3.29938231
12pericardium development (GO:0060039)3.26257995
13regulation of ARF protein signal transduction (GO:0032012)3.25566122
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24908656
15L-phenylalanine catabolic process (GO:0006559)3.24908656
16positive regulation of fatty acid beta-oxidation (GO:0032000)3.14069669
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.11239421
18complement activation, alternative pathway (GO:0006957)3.07222135
19regulation of fatty acid beta-oxidation (GO:0031998)3.02250707
20establishment of protein localization to Golgi (GO:0072600)3.01266880
21hypotonic response (GO:0006971)2.97699199
22sodium ion export (GO:0071436)2.96624332
23positive regulation of fibroblast migration (GO:0010763)2.94841454
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.94754555
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.94003354
26L-phenylalanine metabolic process (GO:0006558)2.94003354
27aromatic amino acid family catabolic process (GO:0009074)2.93111434
28kynurenine metabolic process (GO:0070189)2.92701760
29substrate-dependent cell migration (GO:0006929)2.92142386
30protein carboxylation (GO:0018214)2.91641097
31peptidyl-glutamic acid carboxylation (GO:0017187)2.91641097
32high-density lipoprotein particle remodeling (GO:0034375)2.91424955
33protein-lipid complex assembly (GO:0065005)2.88200883
34collagen fibril organization (GO:0030199)2.85958075
35regulation of protein activation cascade (GO:2000257)2.84822000
36positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.84231275
37homocysteine metabolic process (GO:0050667)2.82960975
38glutamate metabolic process (GO:0006536)2.81948461
39positive regulation of lipid catabolic process (GO:0050996)2.81196639
40reverse cholesterol transport (GO:0043691)2.81021361
41sequestering of extracellular ligand from receptor (GO:0035581)2.78727854
42plasma lipoprotein particle assembly (GO:0034377)2.78688608
43protein targeting to Golgi (GO:0000042)2.76469604
44negative regulation of fibrinolysis (GO:0051918)2.76253832
45phospholipid efflux (GO:0033700)2.75628345
46endodermal cell differentiation (GO:0035987)2.75461603
47phospholipid translocation (GO:0045332)2.74903681
48lipid translocation (GO:0034204)2.74903681
49cholesterol efflux (GO:0033344)2.74674651
50retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73019425
51negative regulation of cholesterol transport (GO:0032375)2.71181980
52negative regulation of sterol transport (GO:0032372)2.71181980
53bile acid biosynthetic process (GO:0006699)2.71112152
54regulation of clathrin-mediated endocytosis (GO:2000369)2.69894335
55regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.68979374
56regulation of triglyceride catabolic process (GO:0010896)2.68259234
57regulation of complement activation (GO:0030449)2.66994319
58plasma lipoprotein particle clearance (GO:0034381)2.66186070
59cellular response to interferon-alpha (GO:0035457)2.66173517
60phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.65405753
61iron ion import (GO:0097286)2.65335361
62detection of molecule of bacterial origin (GO:0032490)2.64027896
63indole-containing compound catabolic process (GO:0042436)2.63748044
64indolalkylamine catabolic process (GO:0046218)2.63748044
65tryptophan catabolic process (GO:0006569)2.63748044
66cellular response to ethanol (GO:0071361)2.63606022
67lysine metabolic process (GO:0006553)2.63110156
68lysine catabolic process (GO:0006554)2.63110156
69triglyceride homeostasis (GO:0070328)2.61313855
70acylglycerol homeostasis (GO:0055090)2.61313855
71cysteine metabolic process (GO:0006534)2.60672587
72mannose metabolic process (GO:0006013)2.60472431
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58826776
74negative regulation of anoikis (GO:2000811)2.58640569
75platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58519731
76bile acid metabolic process (GO:0008206)2.56492876
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.53838246
78tryptophan metabolic process (GO:0006568)2.53649601
79regulation of fibroblast migration (GO:0010762)2.53265875
80positive regulation of receptor recycling (GO:0001921)2.52371234
81valine metabolic process (GO:0006573)2.52146814
82regulation of bile acid biosynthetic process (GO:0070857)2.51407159
83chondrocyte proliferation (GO:0035988)2.51398227
84protein localization to endosome (GO:0036010)2.50753086
85positive regulation of natural killer cell differentiation (GO:0032825)2.49873819
86positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49769029
87lipoprotein transport (GO:0042953)2.49430709
88regulation of fibrinolysis (GO:0051917)2.47553906
89growth hormone receptor signaling pathway (GO:0060396)2.47064776
90heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.47014347
91membrane raft organization (GO:0031579)2.46496589
92stress fiber assembly (GO:0043149)2.45309292
93regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45287675
94low-density lipoprotein particle clearance (GO:0034383)2.45232243
95cell-substrate junction assembly (GO:0007044)2.44217405
96fibroblast migration (GO:0010761)2.43168376
97positive regulation of histone deacetylation (GO:0031065)2.42871991
98regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.42582123
99plasma lipoprotein particle remodeling (GO:0034369)2.42244418
100protein-lipid complex remodeling (GO:0034368)2.42244418
101macromolecular complex remodeling (GO:0034367)2.42244418
102cortical actin cytoskeleton organization (GO:0030866)2.41818379
103negative regulation of T-helper cell differentiation (GO:0045623)2.40095819
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.40095819
105interleukin-6-mediated signaling pathway (GO:0070102)2.39382401
106regulation of T-helper 1 cell differentiation (GO:0045625)2.39332338
107cellular modified amino acid catabolic process (GO:0042219)2.38853016
108locomotory exploration behavior (GO:0035641)2.38802968
109alanine transport (GO:0032328)2.38713000
110very-low-density lipoprotein particle assembly (GO:0034379)2.38350520
1112-oxoglutarate metabolic process (GO:0006103)2.37505754
112barbed-end actin filament capping (GO:0051016)2.37498693
113negative regulation of interleukin-12 production (GO:0032695)2.36293311
114negative regulation of lipase activity (GO:0060192)2.35949128
115sulfur amino acid catabolic process (GO:0000098)2.35902784
116positive regulation of fatty acid oxidation (GO:0046321)2.35760801
117activation of protein kinase A activity (GO:0034199)2.34820236
118import into cell (GO:0098657)2.34240920
119embryonic process involved in female pregnancy (GO:0060136)2.33957640
120adhesion of symbiont to host cell (GO:0044650)2.33747411
121virion attachment to host cell (GO:0019062)2.33747411
122positive regulation of natural killer cell activation (GO:0032816)2.33412222
123negative regulation of lipid transport (GO:0032369)2.33360563
124positive regulation of glycolytic process (GO:0045821)2.33237659
125embryonic retina morphogenesis in camera-type eye (GO:0060059)2.32996707
126endoplasmic reticulum organization (GO:0007029)2.31960994
127extracellular matrix assembly (GO:0085029)2.31882295
128fatty acid homeostasis (GO:0055089)2.31848995
129tyrosine metabolic process (GO:0006570)2.31053282
130fatty acid transmembrane transport (GO:1902001)2.30890218
131protein-lipid complex subunit organization (GO:0071825)2.30515597
132linoleic acid metabolic process (GO:0043651)2.30254481
133regulation of necroptotic process (GO:0060544)2.30051256
134synaptic vesicle maturation (GO:0016188)2.29695232
135regulation of cholesterol storage (GO:0010885)2.28214567
136negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27878202
137regulation of protein polyubiquitination (GO:1902914)2.27605923
138lipoprotein metabolic process (GO:0042157)2.25579501
139negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.25363412
140venous blood vessel morphogenesis (GO:0048845)2.24605742
141bile acid and bile salt transport (GO:0015721)2.24371594
142establishment of nucleus localization (GO:0040023)2.24205369
143pathway-restricted SMAD protein phosphorylation (GO:0060389)2.24082062
144regulation of lipid catabolic process (GO:0050994)2.23726479
145cellular potassium ion homeostasis (GO:0030007)2.22766217
146positive regulation of glycogen biosynthetic process (GO:0045725)2.21423382
147plasma lipoprotein particle organization (GO:0071827)2.21289149
148positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.19491273
149positive regulation of gamma-delta T cell activation (GO:0046645)2.19458144
150negative regulation of fatty acid transport (GO:2000192)2.19274185
151macrophage activation involved in immune response (GO:0002281)2.17794462
152response to laminar fluid shear stress (GO:0034616)2.16790701
153endocardial cushion development (GO:0003197)2.16689973
154regulation of extracellular matrix disassembly (GO:0010715)2.16382624
155regulation of T-helper 2 cell differentiation (GO:0045628)2.14713627
156cortical cytoskeleton organization (GO:0030865)2.13828954
157negative regulation of osteoblast proliferation (GO:0033689)2.13607499
158mesodermal cell differentiation (GO:0048333)2.12341006
159regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.11427465
160regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.08915500
161chondroitin sulfate biosynthetic process (GO:0030206)2.07855790
162cellular response to vitamin (GO:0071295)2.07652229
163smooth muscle tissue development (GO:0048745)2.07272152
164mesenchymal-epithelial cell signaling (GO:0060638)2.05826416
165regulation of membrane protein ectodomain proteolysis (GO:0051043)2.05647837
166response to fluid shear stress (GO:0034405)2.05343100
167germinal center formation (GO:0002467)2.04810256
168regulation of macrophage cytokine production (GO:0010935)2.04611869
169regulation of early endosome to late endosome transport (GO:2000641)2.04454170
170regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.03891174
171regulation of anoikis (GO:2000209)2.03765377
172regulation of vitamin D biosynthetic process (GO:0060556)2.02579542
173blood vessel maturation (GO:0001955)2.02518143
174response to muramyl dipeptide (GO:0032495)2.01224411
175positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.00723541
176hyaluronan catabolic process (GO:0030214)2.00131666
177response to peptidoglycan (GO:0032494)2.00066427
178oligosaccharide catabolic process (GO:0009313)1.99453672
179negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)1.99225583
180negative regulation of cell killing (GO:0031342)1.98331188
181negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.98331188
182regulation of transforming growth factor beta1 production (GO:0032908)1.98240820
183apoptotic cell clearance (GO:0043277)1.98135065
184positive regulation of macrophage cytokine production (GO:0060907)1.95927566
185sprouting angiogenesis (GO:0002040)1.94948920
186kidney mesenchyme development (GO:0072074)1.94900635
187collagen metabolic process (GO:0032963)1.94625630
188negative regulation of protein localization to plasma membrane (GO:1903077)1.94607406
189regulation of type I interferon-mediated signaling pathway (GO:0060338)1.94495233
190positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.94396613
191cellular extravasation (GO:0045123)1.94267275
192SMAD protein complex assembly (GO:0007183)1.93880438
193cell-substrate adherens junction assembly (GO:0007045)1.93433657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.06606424
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.17790437
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.05934094
4NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.76656534
5PPARA_22158963_ChIP-Seq_LIVER_Mouse2.70740860
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.68169986
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39025232
8* BRD4_25478319_ChIP-Seq_HGPS_Human2.22958540
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.13439716
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12480360
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12099491
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.99689395
13GATA1_22025678_ChIP-Seq_K562_Human1.93984523
14CJUN_26792858_Chip-Seq_BT549_Human1.91581267
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90206952
16IRF8_27001747_Chip-Seq_BMDM_Mouse1.87004547
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86296687
18DROSHA_22980978_ChIP-Seq_HELA_Human1.85832611
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.85574186
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.85090646
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84223353
22EP300_21415370_ChIP-Seq_HL-1_Mouse1.77414750
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75572784
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70255012
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69505646
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69106453
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66304314
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64867416
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60866968
30CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60028152
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55978158
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53705279
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53705279
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.46795641
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45404027
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44545571
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43787903
38AR_21572438_ChIP-Seq_LNCaP_Human1.43372167
39JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42508536
40CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40491700
41RUNX_20019798_ChIP-Seq_JUKART_Human1.40088543
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39606697
43TP53_16413492_ChIP-PET_HCT116_Human1.38956518
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38630262
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.38276003
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.37629357
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.37459110
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.37380836
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37219418
50TP53_18474530_ChIP-ChIP_U2OS_Human1.35589909
51JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33880823
52GATA1_19941826_ChIP-Seq_K562_Human1.33070044
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32365564
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.31831604
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.31284897
56SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30463739
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28711553
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28145547
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27580958
60GBX2_23144817_ChIP-Seq_PC3_Human1.27298164
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25693089
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25576278
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23606915
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22751556
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.19596257
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19076876
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18341267
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.17490339
69KDM2B_26808549_Chip-Seq_DND41_Human1.17104492
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16707373
71AHR_22903824_ChIP-Seq_MCF-7_Human1.16653514
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15965318
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.15370396
74TCF7_22412390_ChIP-Seq_EML_Mouse1.14314969
75KDM2B_26808549_Chip-Seq_K562_Human1.14235842
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11415122
77GATA2_19941826_ChIP-Seq_K562_Human1.11354439
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.10839213
79CLOCK_20551151_ChIP-Seq_293T_Human1.10487070
80TP63_23658742_ChIP-Seq_EP156T_Human1.10166924
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.09683023
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.08677051
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06650155
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.06344195
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.06344195
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05986465
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05834500
88RXR_22108803_ChIP-Seq_LS180_Human1.05565080
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04626261
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04518773
91NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04460130
92SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04354323
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.04174324
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03797069
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03712500
96PU_27001747_Chip-Seq_BMDM_Mouse1.03106322
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.02988217
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01795513
99HNF4A_19822575_ChIP-Seq_HepG2_Human1.01091461
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00740482
101AR_19668381_ChIP-Seq_PC3_Human1.00543438
102FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00362504
103STAT3_23295773_ChIP-Seq_U87_Human1.00270281
104KDM2B_26808549_Chip-Seq_JURKAT_Human1.00268122
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99734949
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98644834
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98429997
108ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98201601
109NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98069307
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97882887
111SMAD4_21799915_ChIP-Seq_A2780_Human0.97811511
112SPI1_23127762_ChIP-Seq_K562_Human0.97554558
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.96086457
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.94454147
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94256191
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93931415
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92873002
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92124704
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91551410
120SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91469964
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90527461
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90138691
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89021898
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88814074
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88482371
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87986747
127TCF4_23295773_ChIP-Seq_U87_Human0.87962667
128EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87700906
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87634011
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87578306
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86711625
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86598312
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86598312
134PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86542988
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86532103
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85563525
137ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83903749
138VDR_24787735_ChIP-Seq_THP-1_Human0.82449599
139AR_25329375_ChIP-Seq_VCAP_Human0.81105550
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80356669
141REST_21632747_ChIP-Seq_MESCs_Mouse0.79480457
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79362719
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79144523
144TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78338686

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.17080433
2MP0005360_urolithiasis5.03860308
3MP0002139_abnormal_hepatobiliary_system4.96123154
4MP0000569_abnormal_digit_pigmentation4.80087127
5MP0005365_abnormal_bile_salt3.97552536
6MP0005085_abnormal_gallbladder_physiolo3.48213866
7MP0003950_abnormal_plasma_membrane3.47986133
8MP0003183_abnormal_peptide_metabolism3.37667325
9MP0003252_abnormal_bile_duct3.27311084
10MP0006054_spinal_hemorrhage2.91731914
11MP0003279_aneurysm2.85859666
12MP0005275_abnormal_skin_tensile2.85576163
13MP0001958_emphysema2.84738794
14MP0010329_abnormal_lipoprotein_level2.70376590
15MP0004859_abnormal_synaptic_plasticity2.49531252
16MP0003300_gastrointestinal_ulcer2.43681262
17MP0009780_abnormal_chondrocyte_physiolo2.33803890
18MP0003705_abnormal_hypodermis_morpholog2.29938677
19MP0008875_abnormal_xenobiotic_pharmacok2.28519311
20MP0009840_abnormal_foam_cell2.21594390
21MP0005503_abnormal_tendon_morphology2.05213478
22MP0001666_abnormal_nutrient_absorption1.99623460
23MP0004130_abnormal_muscle_cell1.98778790
24MP0004272_abnormal_basement_membrane1.96538742
25MP0005451_abnormal_body_composition1.94700585
26MP0005023_abnormal_wound_healing1.89517983
27MP0010234_abnormal_vibrissa_follicle1.89268895
28MP0003172_abnormal_lysosome_physiology1.88793381
29MP0005257_abnormal_intraocular_pressure1.88557361
30MP0003656_abnormal_erythrocyte_physiolo1.81751179
31MP0003045_fibrosis1.81095578
32MP0003191_abnormal_cellular_cholesterol1.77333735
33MP0008961_abnormal_basal_metabolism1.74060137
34MP0000609_abnormal_liver_physiology1.71309894
35MP0003828_pulmonary_edema1.67901888
36MP0000767_abnormal_smooth_muscle1.64889966
37MP0003436_decreased_susceptibility_to1.62661877
38MP0002118_abnormal_lipid_homeostasis1.59857565
39MP0003868_abnormal_feces_composition1.58887142
40MP0001542_abnormal_bone_strength1.55442297
41MP0002332_abnormal_exercise_endurance1.54718336
42MP0002909_abnormal_adrenal_gland1.51754561
43MP0005623_abnormal_meninges_morphology1.50663982
44MP0005670_abnormal_white_adipose1.49897595
45MP0003690_abnormal_glial_cell1.48867125
46MP0001835_abnormal_antigen_presentation1.46064906
47MP0000604_amyloidosis1.42368292
48MP0006082_CNS_inflammation1.40453805
49MP0003724_increased_susceptibility_to1.40352581
50MP0005164_abnormal_response_to1.38805481
51MP0010368_abnormal_lymphatic_system1.38634650
52MP0002166_altered_tumor_susceptibility1.38585143
53MP0002998_abnormal_bone_remodeling1.30926083
54MP0001533_abnormal_skeleton_physiology1.30831653
55MP0000733_abnormal_muscle_development1.30564599
56MP0005171_absent_coat_pigmentation1.30364254
57MP0003448_altered_tumor_morphology1.26322931
58MP0000015_abnormal_ear_pigmentation1.22862048
59MP0005083_abnormal_biliary_tract1.21702986
60MP0003195_calcinosis1.21071250
61MP0002060_abnormal_skin_morphology1.19893312
62MP0005666_abnormal_adipose_tissue1.18510659
63MP0005058_abnormal_lysosome_morphology1.16053162
64MP0002419_abnormal_innate_immunity1.15638632
65MP0005409_darkened_coat_color1.15236657
66MP0004808_abnormal_hematopoietic_stem1.14839435
67MP0005332_abnormal_amino_acid1.14373759
68MP0004883_abnormal_blood_vessel1.14123486
69MP0004947_skin_inflammation1.12905442
70MP0010352_gastrointestinal_tract_polyps1.12313466
71MP0002896_abnormal_bone_mineralization1.10640160
72MP0002876_abnormal_thyroid_physiology1.10346084
73MP0010307_abnormal_tumor_latency1.10268538
74MP0005076_abnormal_cell_differentiation1.09986759
75MP0003941_abnormal_skin_development1.08449686
76MP0002254_reproductive_system_inflammat1.08209734
77MP0003453_abnormal_keratinocyte_physiol1.07501500
78MP0005584_abnormal_enzyme/coenzyme_acti1.05182021
79MP0003635_abnormal_synaptic_transmissio1.04962799
80MP0005595_abnormal_vascular_smooth1.04251131
81MP0003303_peritoneal_inflammation1.03903886
82MP0005334_abnormal_fat_pad1.03742248
83MP0003329_amyloid_beta_deposits1.01729307
84MP0001243_abnormal_dermal_layer1.01349006
85MP0003763_abnormal_thymus_physiology1.00218730
86MP0005319_abnormal_enzyme/_coenzyme0.99759082
87MP0002295_abnormal_pulmonary_circulatio0.99657843
88MP0005375_adipose_tissue_phenotype0.99551470
89MP0000685_abnormal_immune_system0.99376002
90MP0004185_abnormal_adipocyte_glucose0.98591667
91MP0002078_abnormal_glucose_homeostasis0.98229053
92MP0002090_abnormal_vision0.98005679
93MP0005387_immune_system_phenotype0.97590737
94MP0001790_abnormal_immune_system0.97590737
95MP0003633_abnormal_nervous_system0.96814836
96MP0000749_muscle_degeneration0.96790505
97MP0008004_abnormal_stomach_pH0.96333167
98MP0002933_joint_inflammation0.96074515
99MP0002138_abnormal_hepatobiliary_system0.94179215
100MP0008260_abnormal_autophagy0.94072403
101MP0005535_abnormal_body_temperature0.94038088
102MP0005000_abnormal_immune_tolerance0.93305429
103MP0009697_abnormal_copulation0.92860356
104MP0010386_abnormal_urinary_bladder0.92009660
105MP0002006_tumorigenesis0.91793212
106MP0003075_altered_response_to0.91347393
107MP0005464_abnormal_platelet_physiology0.91217535
108MP0002971_abnormal_brown_adipose0.91060868
109MP0005390_skeleton_phenotype0.90470490
110MP0002089_abnormal_postnatal_growth/wei0.89051830
111MP0001915_intracranial_hemorrhage0.88608974
112MP0004084_abnormal_cardiac_muscle0.88437032
113MP0000003_abnormal_adipose_tissue0.88394977
114MP0002928_abnormal_bile_duct0.87579146
115MP0004270_analgesia0.87541761
116MP0003091_abnormal_cell_migration0.87418021
117MP0002168_other_aberrant_phenotype0.87416763
118MP0009785_altered_susceptibility_to0.85438804
119MP0003787_abnormal_imprinting0.85339310
120MP0002822_catalepsy0.85297067
121MP0005621_abnormal_cell_physiology0.84898839
122MP0000858_altered_metastatic_potential0.83992223
123MP0002405_respiratory_system_inflammati0.83243021
124MP0005647_abnormal_sex_gland0.82616081
125MP0001177_atelectasis0.82418480
126MP0004233_abnormal_muscle_weight0.81972204
127MP0000759_abnormal_skeletal_muscle0.81490825
128MP0000371_diluted_coat_color0.81397079
129MP0002108_abnormal_muscle_morphology0.80646723
130MP0009672_abnormal_birth_weight0.79988729
131MP0004134_abnormal_chest_morphology0.79617675
132MP0000598_abnormal_liver_morphology0.76695337
133MP0002452_abnormal_antigen_presenting0.76685905
134MP0005397_hematopoietic_system_phenotyp0.76228837
135MP0001545_abnormal_hematopoietic_system0.76228837
136MP0002063_abnormal_learning/memory/cond0.75647747
137MP0004036_abnormal_muscle_relaxation0.75272986
138MP0009046_muscle_twitch0.74548187
139MP0005508_abnormal_skeleton_morphology0.74394432
140MP0001501_abnormal_sleep_pattern0.73905421
141MP0003221_abnormal_cardiomyocyte_apopto0.73724338
142MP0001851_eye_inflammation0.73393201
143MP0005025_abnormal_response_to0.72822542
144MP0000249_abnormal_blood_vessel0.71870624
145MP0005448_abnormal_energy_balance0.71853175
146MP0009764_decreased_sensitivity_to0.71842050
147MP0002148_abnormal_hypersensitivity_rea0.71700637
148MP0002128_abnormal_blood_circulation0.71484558
149MP0000751_myopathy0.71262682
150MP0000427_abnormal_hair_cycle0.70384442
151MP0002723_abnormal_immune_serum0.70326629
152MP0003631_nervous_system_phenotype0.68624229
153MP0004510_myositis0.67818291
154MP0003566_abnormal_cell_adhesion0.67664400
155MP0004019_abnormal_vitamin_homeostasis0.67598770
156MP0009765_abnormal_xenobiotic_induced0.66954668
157MP0009115_abnormal_fat_cell0.66676963
158MP0001299_abnormal_eye_distance/0.65200363
159MP0000013_abnormal_adipose_tissue0.64780824
160MP0001881_abnormal_mammary_gland0.64154384
161MP0008874_decreased_physiological_sensi0.62965585
162MP0002877_abnormal_melanocyte_morpholog0.62257919
163MP0008569_lethality_at_weaning0.61109044
164MP0000747_muscle_weakness0.60857817
165MP0002064_seizures0.60782067
166MP0005167_abnormal_blood-brain_barrier0.58337883
167MP0001661_extended_life_span0.58155150
168MP0009384_cardiac_valve_regurgitation0.57902115
169MP0001873_stomach_inflammation0.57698208
170MP0005310_abnormal_salivary_gland0.56783277
171MP0005220_abnormal_exocrine_pancreas0.56712175
172MP0002269_muscular_atrophy0.56363056
173MP0009763_increased_sensitivity_to0.55867623

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.54664869
2Deep venous thrombosis (HP:0002625)4.03729917
3Premature rupture of membranes (HP:0001788)4.03571845
4Aortic dissection (HP:0002647)3.84073003
5Spondylolisthesis (HP:0003302)3.83942401
6Vascular tortuosity (HP:0004948)3.76096210
7Arterial tortuosity (HP:0005116)3.59275738
8Xanthomatosis (HP:0000991)3.34884258
9Intrahepatic cholestasis (HP:0001406)3.33803099
10Epidermoid cyst (HP:0200040)3.07570342
11Complement deficiency (HP:0004431)3.07562558
12Cervical subluxation (HP:0003308)3.00016399
13Myocardial infarction (HP:0001658)2.93184573
14Type 1 muscle fiber predominance (HP:0003803)2.87883534
15Macroorchidism (HP:0000053)2.87393087
16Osteolytic defects of the hand bones (HP:0009699)2.85160398
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.85160398
18Dilatation of the ascending aorta (HP:0005111)2.82997279
19Peritonitis (HP:0002586)2.82254954
20Ankle contracture (HP:0006466)2.80236819
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78197654
22Acanthocytosis (HP:0001927)2.77619859
23Follicular hyperkeratosis (HP:0007502)2.76447892
24Hypoalphalipoproteinemia (HP:0003233)2.71400473
25Hypobetalipoproteinemia (HP:0003563)2.70672294
26Wormian bones (HP:0002645)2.70655060
27Overgrowth (HP:0001548)2.69445959
28Syringomyelia (HP:0003396)2.59500032
29Spinal cord lesions (HP:0100561)2.59500032
30Hyperlipoproteinemia (HP:0010980)2.58899845
31Hypolipoproteinemia (HP:0010981)2.57019705
32Soft skin (HP:0000977)2.53629349
33Abnormality of the common coagulation pathway (HP:0010990)2.53506906
34Slender build (HP:0001533)2.50116090
35Genu recurvatum (HP:0002816)2.49272893
36Abnormality of liposaccharide metabolism (HP:0010968)2.48913395
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.48913395
38Abnormality of glycolipid metabolism (HP:0010969)2.48913395
39Skin nodule (HP:0200036)2.45503622
40Abnormality of the lower motor neuron (HP:0002366)2.44330777
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42421758
42Atrophic scars (HP:0001075)2.41938921
43Broad metatarsal (HP:0001783)2.41371894
44Thoracolumbar scoliosis (HP:0002944)2.41366111
45Postural instability (HP:0002172)2.40705931
46Prolonged partial thromboplastin time (HP:0003645)2.39906391
47Hypochromic microcytic anemia (HP:0004840)2.38836692
48Spinal rigidity (HP:0003306)2.34351627
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34031389
50Aortic regurgitation (HP:0001659)2.33736081
51Dysmetric saccades (HP:0000641)2.33409369
52Vertebral compression fractures (HP:0002953)2.32718947
53Hematochezia (HP:0002573)2.30368815
54Abnormality of the fingertips (HP:0001211)2.30005519
55Abnormality of sulfur amino acid metabolism (HP:0004339)2.28772919
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27133332
57Mitral stenosis (HP:0001718)2.26767908
58Poikilocytosis (HP:0004447)2.19992257
59Joint hemorrhage (HP:0005261)2.18555940
60Mucopolysacchariduria (HP:0008155)2.17995099
61Urinary glycosaminoglycan excretion (HP:0003541)2.17995099
62Abnormality of complement system (HP:0005339)2.17376127
63Absent frontal sinuses (HP:0002688)2.17047187
64Bladder diverticulum (HP:0000015)2.17017989
65Joint laxity (HP:0001388)2.16694919
66Ovoid vertebral bodies (HP:0003300)2.15771698
67Dysostosis multiplex (HP:0000943)2.15090230
68Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.13604757
69Cerebral aneurysm (HP:0004944)2.07199412
70Increased variability in muscle fiber diameter (HP:0003557)2.06571957
71Autoimmune thrombocytopenia (HP:0001973)2.03833315
72Hemiplegia (HP:0002301)2.02613012
73Resting tremor (HP:0002322)2.01332892
74Neonatal short-limb short stature (HP:0008921)2.00651453
75Aneurysm (HP:0002617)2.00130476
76Subacute progressive viral hepatitis (HP:0006572)2.00031013
77Mitral regurgitation (HP:0001653)1.99836731
78Hypoplasia of the iris (HP:0007676)1.99193106
79Distal upper limb amyotrophy (HP:0007149)1.99025089
80Upper limb amyotrophy (HP:0009129)1.99025089
81Broad ribs (HP:0000885)1.98899067
82Thin bony cortex (HP:0002753)1.98463098
83Hypercholesterolemia (HP:0003124)1.97933527
84Blue sclerae (HP:0000592)1.97618568
85Flared iliac wings (HP:0002869)1.97157317
86Abnormality of the intrinsic pathway (HP:0010989)1.95466439
87Dislocated radial head (HP:0003083)1.95371035
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.94720164
89Relative macrocephaly (HP:0004482)1.94379511
90Long eyelashes (HP:0000527)1.94000774
91Status epilepticus (HP:0002133)1.93523419
92Conjugated hyperbilirubinemia (HP:0002908)1.93208009
93Focal seizures (HP:0007359)1.92532281
94Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.92443326
95Abnormal social behavior (HP:0012433)1.92312561
96Impaired social interactions (HP:0000735)1.92312561
97Persistence of primary teeth (HP:0006335)1.91652146
98Ketosis (HP:0001946)1.90673610
99Frequent falls (HP:0002359)1.90188080
100Global brain atrophy (HP:0002283)1.89111457
101Hand muscle atrophy (HP:0009130)1.88035892
102Hypoglycemic seizures (HP:0002173)1.87921516
103Delayed closure of the anterior fontanelle (HP:0001476)1.86610362
104Turricephaly (HP:0000262)1.86503098
105Shallow orbits (HP:0000586)1.86269858
106Fat malabsorption (HP:0002630)1.85879714
107Orchitis (HP:0100796)1.85733708
108Increased connective tissue (HP:0009025)1.84973921
109Long toe (HP:0010511)1.84268632
110Cardiovascular calcification (HP:0011915)1.83665911
111Aortic aneurysm (HP:0004942)1.83198880
112Asymmetric septal hypertrophy (HP:0001670)1.82063413
113Cholelithiasis (HP:0001081)1.81166261
114Spontaneous hematomas (HP:0007420)1.79897403
115Short nail (HP:0001799)1.79279778
116Aortic valve stenosis (HP:0001650)1.77893933
117Hyperextensible skin (HP:0000974)1.75993669
118Intention tremor (HP:0002080)1.75968791
119Abnormal gallbladder morphology (HP:0012437)1.75601722
120Abnormality of skeletal muscle fiber size (HP:0012084)1.74910684
121Hypoplasia of the thymus (HP:0000778)1.74421859
122Fragile skin (HP:0001030)1.73687139
123Urinary bladder sphincter dysfunction (HP:0002839)1.73643633
124Hydroxyprolinuria (HP:0003080)1.73602805
125Abnormality of proline metabolism (HP:0010907)1.73602805
126Eczematoid dermatitis (HP:0000976)1.72730409
127Action tremor (HP:0002345)1.72189840
128Esophageal varix (HP:0002040)1.71989855
129Abnormality of the radial head (HP:0003995)1.71390855
130Mitral valve prolapse (HP:0001634)1.71163399
131Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.69978764
132Abnormality of macrophages (HP:0004311)1.69828279
133Abnormality of the Achilles tendon (HP:0005109)1.69772721
134Coarse hair (HP:0002208)1.69752821
135Sensorimotor neuropathy (HP:0007141)1.69648241
136Mildly elevated creatine phosphokinase (HP:0008180)1.69532934
137Upper motor neuron abnormality (HP:0002127)1.69413213
138Lower limb amyotrophy (HP:0007210)1.68782967
139Gingival bleeding (HP:0000225)1.67764492
140Myositis (HP:0100614)1.67684887
141Abnormality of skull ossification (HP:0002703)1.67312811
142Elbow flexion contracture (HP:0002987)1.66967362
143Narrow palate (HP:0000189)1.66374859
144Limb hypertonia (HP:0002509)1.65742700
145Broad face (HP:0000283)1.65671712
146Retrobulbar optic neuritis (HP:0100654)1.65568732
147Optic neuritis (HP:0100653)1.65568732
148Abnormal foot bone ossification (HP:0010675)1.65556012
149Hypoglycemic coma (HP:0001325)1.65258026
150Hyperglycemia (HP:0003074)1.64473640
151Hemorrhage of the eye (HP:0011885)1.62088514
152Reticulocytosis (HP:0001923)1.61800131
153Wrist flexion contracture (HP:0001239)1.61523432
154Increased mean platelet volume (HP:0011877)1.61515351
155Genetic anticipation (HP:0003743)1.61367244
156Abnormality of the acetabulum (HP:0003170)1.61251115
157Protuberant abdomen (HP:0001538)1.60336566
158Bowel diverticulosis (HP:0005222)1.60326312
159Abnormality of purine metabolism (HP:0004352)1.59528422
160Drooling (HP:0002307)1.58785252
161Excessive salivation (HP:0003781)1.58785252
162Abnormality of dentin (HP:0010299)1.58751179
163Lymphangioma (HP:0100764)1.58313241
164Hypoplastic ischia (HP:0003175)1.58290728
165Pseudobulbar signs (HP:0002200)1.58170763
166Aqueductal stenosis (HP:0002410)1.58071529
167Hepatocellular carcinoma (HP:0001402)1.57364553
168Hyporeflexia of lower limbs (HP:0002600)1.57013267
169Wide anterior fontanel (HP:0000260)1.56691750
170Vertebral arch anomaly (HP:0008438)1.56093529
171Joint stiffness (HP:0001387)1.55600081
172Abnormal platelet volume (HP:0011876)1.55289701
173Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.55144886
174Biconcave vertebral bodies (HP:0004586)1.54633838
175Mild short stature (HP:0003502)1.54622055
176* Heterotopia (HP:0002282)1.54060550
177Camptodactyly of toe (HP:0001836)1.53907402
178Distal lower limb amyotrophy (HP:0008944)1.53558522
179Visual hallucinations (HP:0002367)1.52803731
180Striae distensae (HP:0001065)1.50518067
181Spastic tetraparesis (HP:0001285)1.50421347
182Increased CSF protein (HP:0002922)1.50091712
183Abnormality of mucopolysaccharide metabolism (HP:0011020)1.50039719
184Abnormality of polysaccharide metabolism (HP:0011012)1.50039719
185Abnormality of glycosaminoglycan metabolism (HP:0004371)1.50039719
186Abnormality of aspartate family amino acid metabolism (HP:0010899)1.49916941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.20222504
2SIK12.71517778
3NEK92.61753704
4TAOK32.38510950
5CAMK1D2.36749326
6DDR22.36160031
7MAP3K102.33996534
8LATS12.29498466
9TRIB32.27799372
10CAMK1G2.23299904
11PRPF4B2.09526758
12CDK121.99293592
13MAP3K91.94965308
14MYLK1.93860314
15TRPM71.89187049
16MAP2K31.87840808
17EEF2K1.87280091
18MAP3K131.86484134
19FRK1.84508034
20PIK3CG1.83015161
21RIPK11.81017184
22PKN21.77635327
23GRK71.74999485
24SGK31.73025082
25DAPK21.72074504
26MAP3K71.70884730
27NTRK31.67222973
28FGFR21.63736042
29PTK61.62988641
30TTN1.58099180
31JAK11.51578044
32SIK21.45899789
33PAK61.44199092
34INSRR1.43142160
35SGK21.42355198
36FGFR41.34797475
37PRKD21.32907829
38SCYL21.32201874
39ZAP701.32164440
40MAP3K21.31944526
41PRKCH1.31578346
42MAP3K61.31261281
43MAP3K31.30293268
44FGFR31.28809938
45CAMKK11.28663363
46MOS1.26483072
47MELK1.26416904
48PAK21.24834160
49TAOK11.23753973
50MAP3K41.20917369
51ERN11.17885029
52PRKD31.17398951
53RET1.11222986
54BLK1.10609614
55STK381.09400808
56PDGFRA1.06515008
57ACVR1B1.05998891
58EPHA41.05351580
59MAP2K41.02921380
60SGK4941.02173291
61SGK2231.02173291
62NLK1.01846822
63RIPK41.01620282
64KSR21.01605572
65KIT1.01502841
66MTOR1.01464423
67IKBKE0.96412446
68TNK20.95925467
69TBK10.93789376
70PDGFRB0.93023144
71JAK20.91663528
72MAP3K140.91320663
73STK30.90322606
74PRKAA10.89319767
75ICK0.89156153
76PDK10.88647094
77PTK2B0.86754647
78EPHA30.85741127
79TAOK20.84966203
80LMTK20.84791227
81TYK20.83702674
82SGK10.82242614
83NTRK10.82038259
84PRKAA20.80362488
85CSK0.79431678
86CDC42BPA0.79286655
87MARK20.78912535
88PAK30.78244250
89CHUK0.77389468
90CDK90.77369642
91CDK60.75561464
92PDPK10.73657104
93BRD40.73407784
94NTRK20.72884842
95ALK0.72533023
96JAK30.72356485
97STK110.71420408
98MAP3K10.70966290
99EPHB10.70128121
100MAP3K50.67274056
101MARK30.67002661
102HCK0.66829721
103WNK10.66483682
104STK100.65826395
105IRAK40.65299348
106MAPK110.62512224
107MAPK120.61780215
108RPS6KA20.61487156
109BMPR20.61324913
110TEC0.60549838
111ERBB40.60214942
112GRK60.59662488
113MAP4K10.57805684
114KSR10.57604689
115ERBB20.57520470
116FLT30.56005970
117BMX0.55792441
118RPS6KA30.55562285
119FES0.54526009
120CDK50.54281987
121PTK20.54253142
122PRKCZ0.54192064
123MAPK70.54172464
124LATS20.53912359
125TXK0.49811744
126GSK3A0.48020119
127ROCK10.47820725
128FGR0.47030792
129PKN10.46410370
130CLK10.45669009
131MAPK100.45666051
132MET0.45447547
133RAF10.44850000
134TGFBR20.44154391
135PHKG20.43907354
136PHKG10.43907354
137LCK0.43867499
138SYK0.43748113
139DYRK1B0.43398239
140DMPK0.43267739
141ROCK20.42719243
142FER0.42339429
143PRKD10.41587086
144IRAK30.40833699
145FGFR10.40112681
146HIPK20.40104654
147CAMK40.40080878
148MAPK80.40050434
149TYRO30.38975684
150FYN0.38772558

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.16176778
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.57590539
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50920776
4Arginine biosynthesis_Homo sapiens_hsa002202.48663522
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95641722
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71341157
7Bile secretion_Homo sapiens_hsa049761.68542054
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.65433626
9Other glycan degradation_Homo sapiens_hsa005111.65249445
10Focal adhesion_Homo sapiens_hsa045101.61233713
11Complement and coagulation cascades_Homo sapiens_hsa046101.60953234
12TNF signaling pathway_Homo sapiens_hsa046681.54851030
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52092343
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51152508
15ABC transporters_Homo sapiens_hsa020101.50588321
16Malaria_Homo sapiens_hsa051441.47578811
17Lysine degradation_Homo sapiens_hsa003101.47249432
18Type II diabetes mellitus_Homo sapiens_hsa049301.45222507
19PPAR signaling pathway_Homo sapiens_hsa033201.41175269
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40136177
21ECM-receptor interaction_Homo sapiens_hsa045121.40099186
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.37519002
23Acute myeloid leukemia_Homo sapiens_hsa052211.35024814
24Proteoglycans in cancer_Homo sapiens_hsa052051.34981638
25Caffeine metabolism_Homo sapiens_hsa002321.33221214
26Amoebiasis_Homo sapiens_hsa051461.32694213
27Tryptophan metabolism_Homo sapiens_hsa003801.31868727
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.28124513
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.25098125
30Toxoplasmosis_Homo sapiens_hsa051451.24890983
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23354024
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19454526
33Fatty acid degradation_Homo sapiens_hsa000711.18690193
34Hepatitis B_Homo sapiens_hsa051611.17226727
35Small cell lung cancer_Homo sapiens_hsa052221.17116703
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16813303
37Adherens junction_Homo sapiens_hsa045201.16310266
38Insulin resistance_Homo sapiens_hsa049311.14658415
39Leishmaniasis_Homo sapiens_hsa051401.14557392
40Lysosome_Homo sapiens_hsa041421.13643202
41Renal cell carcinoma_Homo sapiens_hsa052111.13076127
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12250504
43Measles_Homo sapiens_hsa051621.10014448
44Bladder cancer_Homo sapiens_hsa052191.10000761
45Prostate cancer_Homo sapiens_hsa052151.07294680
46MicroRNAs in cancer_Homo sapiens_hsa052061.07087313
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06172666
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05862798
49Staphylococcus aureus infection_Homo sapiens_hsa051501.05508541
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03219743
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.02619282
52Hepatitis C_Homo sapiens_hsa051601.02558943
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01938155
54Dorso-ventral axis formation_Homo sapiens_hsa043201.01726019
55Influenza A_Homo sapiens_hsa051641.01596884
56mTOR signaling pathway_Homo sapiens_hsa041501.00268871
57Tuberculosis_Homo sapiens_hsa051520.99741652
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98885759
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97670675
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97412138
61Pertussis_Homo sapiens_hsa051330.95597659
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94951813
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94884504
64Dilated cardiomyopathy_Homo sapiens_hsa054140.94189653
65Olfactory transduction_Homo sapiens_hsa047400.93977311
66Fatty acid metabolism_Homo sapiens_hsa012120.92723212
67Starch and sucrose metabolism_Homo sapiens_hsa005000.92114290
68African trypanosomiasis_Homo sapiens_hsa051430.91727144
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91639288
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90557097
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89812881
72T cell receptor signaling pathway_Homo sapiens_hsa046600.89587723
73VEGF signaling pathway_Homo sapiens_hsa043700.89558533
74Fatty acid biosynthesis_Homo sapiens_hsa000610.89319366
75Melanoma_Homo sapiens_hsa052180.88815142
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88381809
77Butanoate metabolism_Homo sapiens_hsa006500.88326118
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.87812512
79Insulin secretion_Homo sapiens_hsa049110.87772587
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.87653389
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86256404
82Shigellosis_Homo sapiens_hsa051310.85696097
83Salivary secretion_Homo sapiens_hsa049700.85624478
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83805306
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83651860
86Glycerolipid metabolism_Homo sapiens_hsa005610.81727181
87Selenocompound metabolism_Homo sapiens_hsa004500.80988223
88Sphingolipid metabolism_Homo sapiens_hsa006000.80233444
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79126031
90Synaptic vesicle cycle_Homo sapiens_hsa047210.78946295
91Salmonella infection_Homo sapiens_hsa051320.78697509
92Circadian entrainment_Homo sapiens_hsa047130.77350421
93Colorectal cancer_Homo sapiens_hsa052100.76961727
94Propanoate metabolism_Homo sapiens_hsa006400.76847253
95GABAergic synapse_Homo sapiens_hsa047270.76639978
96Glioma_Homo sapiens_hsa052140.76288255
97Apoptosis_Homo sapiens_hsa042100.74832597
98Glucagon signaling pathway_Homo sapiens_hsa049220.74690662
99Phagosome_Homo sapiens_hsa041450.74100237
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73684120
101Inositol phosphate metabolism_Homo sapiens_hsa005620.72838307
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72204967
103Morphine addiction_Homo sapiens_hsa050320.72159934
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71912850
105Long-term potentiation_Homo sapiens_hsa047200.71476434
106AMPK signaling pathway_Homo sapiens_hsa041520.71201688
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71053515
108Insulin signaling pathway_Homo sapiens_hsa049100.69802986
109Hematopoietic cell lineage_Homo sapiens_hsa046400.69319519
110Pathways in cancer_Homo sapiens_hsa052000.69245677
111Fat digestion and absorption_Homo sapiens_hsa049750.68801716
112MAPK signaling pathway_Homo sapiens_hsa040100.68682794
113beta-Alanine metabolism_Homo sapiens_hsa004100.66385795
114Rap1 signaling pathway_Homo sapiens_hsa040150.65822989
115Viral myocarditis_Homo sapiens_hsa054160.65794510
116Legionellosis_Homo sapiens_hsa051340.64890215
117TGF-beta signaling pathway_Homo sapiens_hsa043500.64864676
118Glutamatergic synapse_Homo sapiens_hsa047240.64597039
119Endocytosis_Homo sapiens_hsa041440.63345323
120GnRH signaling pathway_Homo sapiens_hsa049120.63270622
121Non-small cell lung cancer_Homo sapiens_hsa052230.63187756
122Renin secretion_Homo sapiens_hsa049240.63174345
123Gastric acid secretion_Homo sapiens_hsa049710.62832179
124Chronic myeloid leukemia_Homo sapiens_hsa052200.62118238
125Oxytocin signaling pathway_Homo sapiens_hsa049210.61921030
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61919357
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61872194
128Thyroid cancer_Homo sapiens_hsa052160.60977665
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.60850544
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.59514280
131Cholinergic synapse_Homo sapiens_hsa047250.59139287
132Estrogen signaling pathway_Homo sapiens_hsa049150.58791733
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58103741
134Peroxisome_Homo sapiens_hsa041460.57713690
135B cell receptor signaling pathway_Homo sapiens_hsa046620.57139213
136cAMP signaling pathway_Homo sapiens_hsa040240.57081190
137ErbB signaling pathway_Homo sapiens_hsa040120.56931875
138cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55870390
139Endometrial cancer_Homo sapiens_hsa052130.55709829
140Choline metabolism in cancer_Homo sapiens_hsa052310.55182532
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52833508
142Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51383084
143FoxO signaling pathway_Homo sapiens_hsa040680.50900271
144Vitamin B6 metabolism_Homo sapiens_hsa007500.50206002
145Thyroid hormone synthesis_Homo sapiens_hsa049180.49847258
146Circadian rhythm_Homo sapiens_hsa047100.49315844
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.48932556
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48700160
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.48156435
150Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46912490
151Prolactin signaling pathway_Homo sapiens_hsa049170.46886538
152Nicotine addiction_Homo sapiens_hsa050330.46504992
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.45048142
154Retinol metabolism_Homo sapiens_hsa008300.43458304
155Biosynthesis of amino acids_Homo sapiens_hsa012300.43012157
156Calcium signaling pathway_Homo sapiens_hsa040200.42156989
157Osteoclast differentiation_Homo sapiens_hsa043800.42112424
158Chemokine signaling pathway_Homo sapiens_hsa040620.41616012
159Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41401761
160Pancreatic cancer_Homo sapiens_hsa052120.40564082
161Amphetamine addiction_Homo sapiens_hsa050310.40243528
162Platelet activation_Homo sapiens_hsa046110.39435068
163Phenylalanine metabolism_Homo sapiens_hsa003600.37479641
164Histidine metabolism_Homo sapiens_hsa003400.37218359

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