EPHA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of posttranscriptional gene silencing (GO:0060147)5.60730890
2regulation of gene silencing by miRNA (GO:0060964)5.60730890
3regulation of gene silencing by RNA (GO:0060966)5.60730890
4hemidesmosome assembly (GO:0031581)5.36448739
5paraxial mesoderm development (GO:0048339)4.61338329
6regulation of hippo signaling (GO:0035330)4.50110265
7nuclear pore organization (GO:0006999)4.38280283
8nuclear pore complex assembly (GO:0051292)4.36607349
9Golgi transport vesicle coating (GO:0048200)4.31846591
10COPI coating of Golgi vesicle (GO:0048205)4.31846591
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.12517560
12negative regulation of chondrocyte differentiation (GO:0032331)4.04851723
13protein localization to endosome (GO:0036010)4.03729286
14establishment of apical/basal cell polarity (GO:0035089)4.01878798
15cell adhesion mediated by integrin (GO:0033627)3.97851036
16mesodermal cell differentiation (GO:0048333)3.94802830
17wound healing, spreading of epidermal cells (GO:0035313)3.93772963
18heterochromatin organization (GO:0070828)3.91148760
19dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.85909889
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.84198867
21positive regulation of SMAD protein import into nucleus (GO:0060391)3.74561191
22folic acid-containing compound biosynthetic process (GO:0009396)3.74116681
23apoptotic process involved in morphogenesis (GO:0060561)3.65610008
24cell-substrate junction assembly (GO:0007044)3.64359645
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58418076
26regulation of SMAD protein import into nucleus (GO:0060390)3.55194037
27polarized epithelial cell differentiation (GO:0030859)3.52676841
28regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.51055472
29epithelial cell-cell adhesion (GO:0090136)3.47287775
30atrioventricular valve morphogenesis (GO:0003181)3.46507148
31semaphorin-plexin signaling pathway (GO:0071526)3.37664148
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.36753861
33protein retention in ER lumen (GO:0006621)3.30777961
34pore complex assembly (GO:0046931)3.30021598
35establishment or maintenance of monopolar cell polarity (GO:0061339)3.28421441
36establishment of monopolar cell polarity (GO:0061162)3.28421441
37regulation of translational fidelity (GO:0006450)3.28158152
38regulation of integrin activation (GO:0033623)3.26159782
39gap junction assembly (GO:0016264)3.23342917
40muscle cell migration (GO:0014812)3.22807316
41substrate-dependent cell migration (GO:0006929)3.21696504
42regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.20495347
43embryonic camera-type eye development (GO:0031076)3.17712708
44regulation of gene silencing (GO:0060968)3.16237755
45regulation of transforming growth factor beta2 production (GO:0032909)3.14827935
46interferon-gamma secretion (GO:0072643)3.13685293
47skin morphogenesis (GO:0043589)3.13640091
48anterior/posterior axis specification, embryo (GO:0008595)3.13071859
49hippo signaling (GO:0035329)3.10526596
50hypotonic response (GO:0006971)3.10378778
51regulation of chemokine secretion (GO:0090196)3.08870106
52wound healing, spreading of cells (GO:0044319)3.08728286
53embryonic process involved in female pregnancy (GO:0060136)3.08290204
54keratinocyte proliferation (GO:0043616)3.05189923
55regulation of water loss via skin (GO:0033561)3.02806362
56endodermal cell differentiation (GO:0035987)3.01566078
57protein localization to microtubule (GO:0035372)3.01040554
58positive regulation of endothelial cell apoptotic process (GO:2000353)3.00427993
59IMP biosynthetic process (GO:0006188)3.00362808
60negative regulation of keratinocyte proliferation (GO:0010839)2.98399228
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98354624
62mitotic nuclear envelope disassembly (GO:0007077)2.96620705
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.95746946
64basement membrane organization (GO:0071711)2.94788891
65renal filtration (GO:0097205)2.94528621
66DNA unwinding involved in DNA replication (GO:0006268)2.92583701
67adherens junction assembly (GO:0034333)2.88143713
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87275736
69negative regulation of cartilage development (GO:0061037)2.84610732
70negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.84162890
71regulation of establishment of planar polarity (GO:0090175)2.83586464
72cell migration involved in sprouting angiogenesis (GO:0002042)2.79269096
73nuclear envelope reassembly (GO:0031468)2.78614479
74mitotic nuclear envelope reassembly (GO:0007084)2.78614479
75protein localization to kinetochore (GO:0034501)2.78124774
76trophectodermal cell differentiation (GO:0001829)2.77131709
77establishment of skin barrier (GO:0061436)2.76559281
78notochord development (GO:0030903)2.76548767
79chromatin assembly (GO:0031497)2.76428126
80membrane disassembly (GO:0030397)2.75632957
81nuclear envelope disassembly (GO:0051081)2.75632957
82regulation of cardioblast differentiation (GO:0051890)2.74718635
83cell junction assembly (GO:0034329)2.74011984
84regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.73190361
85lung vasculature development (GO:0060426)2.70322711
86branching involved in salivary gland morphogenesis (GO:0060445)2.70046957
87renal system development (GO:0072001)2.69686601
88endothelial cell chemotaxis (GO:0035767)2.69085579
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.67459023
90positive regulation of pseudopodium assembly (GO:0031274)2.67163433
91regulation of histone H3-K9 methylation (GO:0051570)2.66148556
92apoptotic process involved in development (GO:1902742)2.65956054
93IMP metabolic process (GO:0046040)2.65033204
94regulation of tight junction assembly (GO:2000810)2.64185021
95focal adhesion assembly (GO:0048041)2.63707578
96cell-substrate adherens junction assembly (GO:0007045)2.63707578
97protein maturation by protein folding (GO:0022417)2.62119974
98DNA replication-dependent nucleosome organization (GO:0034723)2.61427724
99DNA replication-dependent nucleosome assembly (GO:0006335)2.61427724
100regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61028376
101intestinal epithelial cell development (GO:0060576)2.59479228
102negative regulation of anoikis (GO:2000811)2.59361009
103tight junction assembly (GO:0070830)2.59277273
104membrane protein ectodomain proteolysis (GO:0006509)2.58773760
105cell junction organization (GO:0034330)2.58032507
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55669183
107cell differentiation involved in embryonic placenta development (GO:0060706)2.55516054
108nodal signaling pathway (GO:0038092)2.54484050
109adherens junction organization (GO:0034332)2.52600887
110cellular protein complex localization (GO:0034629)2.52564816
111* activation of Rac GTPase activity (GO:0032863)2.52532840
112mitotic chromosome condensation (GO:0007076)2.51549673
113glomerular visceral epithelial cell development (GO:0072015)2.51480140
114dosage compensation (GO:0007549)2.51404006
115cell migration involved in gastrulation (GO:0042074)2.50226622
116spindle assembly involved in mitosis (GO:0090307)2.50176655
117embryonic placenta development (GO:0001892)2.50113716
118actin filament bundle assembly (GO:0051017)2.50033869
119actin filament bundle organization (GO:0061572)2.50033869
120positive regulation of blood vessel endothelial cell migration (GO:0043536)2.48415867
121protein hydroxylation (GO:0018126)2.47532396
122G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.47489768
123regulation of mitotic spindle organization (GO:0060236)2.47307777
124lung-associated mesenchyme development (GO:0060484)2.47030257
125negative regulation of stem cell proliferation (GO:2000647)2.46166020
126mRNA transcription (GO:0009299)2.46148913
127ribosome assembly (GO:0042255)2.45045012
128membrane raft organization (GO:0031579)2.44745064
129cochlea morphogenesis (GO:0090103)2.44493506
130morphogenesis of embryonic epithelium (GO:0016331)2.44441325
131desmosome organization (GO:0002934)2.44030191
132regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43108781
133regulation of helicase activity (GO:0051095)2.41667088
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41135645
135hepatocyte apoptotic process (GO:0097284)2.41056739
136blood vessel endothelial cell migration (GO:0043534)2.40946290
137stress fiber assembly (GO:0043149)2.39528712
138regulation of telomere maintenance via telomerase (GO:0032210)2.39290736
139convergent extension (GO:0060026)2.39281117
140determination of adult lifespan (GO:0008340)2.39143877
141regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38138984
142negative regulation of catenin import into nucleus (GO:0035414)2.37830069
143chondrocyte proliferation (GO:0035988)2.37823263
144cellular response to vitamin D (GO:0071305)2.37424377
145proline biosynthetic process (GO:0006561)2.36801907
146developmental programmed cell death (GO:0010623)2.35984286
147DNA duplex unwinding (GO:0032508)2.35978671
148regulation of anoikis (GO:2000209)2.35544337
149endothelial cell morphogenesis (GO:0001886)2.34443167
150DNA geometric change (GO:0032392)2.33962181
151mammary gland development (GO:0030879)2.32642682
152regulation of cell fate specification (GO:0042659)2.32367027
153negative regulation of cell fate specification (GO:0009996)2.31927751
154trophoblast giant cell differentiation (GO:0060707)2.31452567
155regulation of translational termination (GO:0006449)2.31141563
156regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.28124436
157negative regulation of gene silencing (GO:0060969)2.27333484
158positive regulation of osteoblast proliferation (GO:0033690)2.26732060
159bundle of His cell to Purkinje myocyte communication (GO:0086069)2.25953095
160DNA replication initiation (GO:0006270)2.25744568
161response to UV-C (GO:0010225)2.24790155
162protein localization to cell surface (GO:0034394)2.24740366
163* branching involved in mammary gland duct morphogenesis (GO:0060444)2.24559783
164mitotic sister chromatid segregation (GO:0000070)2.23227884
165regulation of spindle organization (GO:0090224)2.23149019
166mitotic metaphase plate congression (GO:0007080)2.22484348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.00357192
2E2F7_22180533_ChIP-Seq_HELA_Human5.72005611
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.47512889
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.21096732
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.18186211
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.18186211
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.18186211
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.76872419
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.76600016
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.63422629
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.55155508
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.53793840
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47008290
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42114648
15TCF3_18692474_ChIP-Seq_MEFs_Mouse2.40910220
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35264794
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22764641
18* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21676542
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16769063
20STAT3_1855785_ChIP-Seq_MESCs_Mouse2.16082787
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.13248635
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.06988453
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.04127686
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04025002
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03137673
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99735785
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.98280906
28TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97942876
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97113588
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.94931436
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.94486113
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91529463
33AR_21909140_ChIP-Seq_LNCAP_Human1.87644442
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86681670
35* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.82333678
36* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80156760
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.79905821
38* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.73987541
39ZNF263_19887448_ChIP-Seq_K562_Human1.72027231
40* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69951046
41* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69156491
42* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69156491
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67675488
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64444747
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64222410
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60192703
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59787954
48CLOCK_20551151_ChIP-Seq_293T_Human1.56997589
49* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55719770
50LXR_22292898_ChIP-Seq_THP-1_Human1.54136415
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54096151
52* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53750723
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49023486
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.48784642
55* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47307635
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47175797
57* ATF3_27146783_Chip-Seq_COLON_Human1.46569261
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40334155
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39104856
60* ESR1_21235772_ChIP-Seq_MCF-7_Human1.38308895
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36492772
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35448624
63NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32702368
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31815285
65* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28788130
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27135801
67SOX2_18692474_ChIP-Seq_MEFs_Mouse1.26727941
68NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23843158
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23768592
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.23519093
71* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.23068422
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21748480
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21684935
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20684487
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20584979
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.20554314
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20369948
78GATA6_25053715_ChIP-Seq_YYC3_Human1.20361317
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19341384
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18735466
81POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18073223
82SOX2_18692474_ChIP-Seq_MESCs_Mouse1.16664769
83* KDM2B_26808549_Chip-Seq_K562_Human1.15579668
84MYC_22102868_ChIP-Seq_BL_Human1.14918502
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14027481
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13803616
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13739126
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.13563212
89PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11994523
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11409874
91* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10996892
92* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10676206
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10107011
94* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09057811
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09031128
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08821067
97ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08280907
98KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08107867
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07431185
100* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07047251
101SOX2_20726797_ChIP-Seq_SW620_Human1.06280087
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06072513
103BRD4_25478319_ChIP-Seq_HGPS_Human1.05535787
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.05282442
105MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05042451
106* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05038854
107* RACK7_27058665_Chip-Seq_MCF-7_Human1.04086973
108* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03773130
109RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02472292
110* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01567370
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01116493
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00110244
113CDX2_20551321_ChIP-Seq_CACO-2_Human0.99916137
114* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99736973
115* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97823493
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97750866
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97645775
118* KLF5_25053715_ChIP-Seq_YYC3_Human0.97302059
119* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97120947
120XRN2_22483619_ChIP-Seq_HELA_Human0.95484677
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95452538
122TET1_21451524_ChIP-Seq_MESCs_Mouse0.95259172
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94619919
124* TCF7_22412390_ChIP-Seq_EML_Mouse0.94537590
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94067848
126* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93761564
127* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92976848
128NANOG_16153702_ChIP-ChIP_HESCs_Human0.91984255
129* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91865971
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91830329
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.91774873
132KAP1_27257070_Chip-Seq_ESCs_Mouse0.91506838
133* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91426065
134* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91198308
135* CJUN_26792858_Chip-Seq_BT549_Human0.91031042
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90941284
137* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90835818
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90311610
139* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89886005
140* ESR2_21235772_ChIP-Seq_MCF-7_Human0.89824101
141* TP53_22127205_ChIP-Seq_IMR90_Human0.89655338
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88277645
143DCP1A_22483619_ChIP-Seq_HELA_Human0.87673425
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87633033
145SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87414059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.54789377
2MP0003705_abnormal_hypodermis_morpholog3.51481180
3MP0003566_abnormal_cell_adhesion2.90531588
4MP0000579_abnormal_nail_morphology2.75764972
5MP0003941_abnormal_skin_development2.73105098
6MP0000537_abnormal_urethra_morphology2.56779260
7MP0010234_abnormal_vibrissa_follicle2.56656925
8MP0004272_abnormal_basement_membrane2.41489632
9MP0010030_abnormal_orbit_morphology2.21398269
10MP0009053_abnormal_anal_canal2.10989022
11MP0005623_abnormal_meninges_morphology2.10718841
12MP0005023_abnormal_wound_healing2.06416946
13MP0005275_abnormal_skin_tensile2.02934717
14MP0004957_abnormal_blastocyst_morpholog1.97030911
15MP0005076_abnormal_cell_differentiation1.89213696
16MP0008438_abnormal_cutaneous_collagen1.88264237
17MP0002796_impaired_skin_barrier1.82661651
18MP0003453_abnormal_keratinocyte_physiol1.70598964
19MP0005501_abnormal_skin_physiology1.70311490
20MP0003111_abnormal_nucleus_morphology1.63411270
21MP0002877_abnormal_melanocyte_morpholog1.60766475
22MP0003693_abnormal_embryo_hatching1.58961415
23MP0004264_abnormal_extraembryonic_tissu1.58359260
24MP0004133_heterotaxia1.58342226
25MP0002060_abnormal_skin_morphology1.57148023
26MP0002254_reproductive_system_inflammat1.52330214
27MP0003077_abnormal_cell_cycle1.50268888
28MP0001849_ear_inflammation1.49902186
29MP0003091_abnormal_cell_migration1.49758705
30MP0004197_abnormal_fetal_growth/weight/1.49748215
31MP0008007_abnormal_cellular_replicative1.48716302
32MP0004185_abnormal_adipocyte_glucose1.46615752
33MP0002086_abnormal_extraembryonic_tissu1.45082090
34MP0000751_myopathy1.42443679
35MP0001730_embryonic_growth_arrest1.41476860
36MP0010307_abnormal_tumor_latency1.40469212
37MP0005409_darkened_coat_color1.39160642
38MP0003119_abnormal_digestive_system1.37950157
39MP0008004_abnormal_stomach_pH1.36904540
40MP0001672_abnormal_embryogenesis/_devel1.36648915
41MP0005380_embryogenesis_phenotype1.36648915
42MP0000350_abnormal_cell_proliferation1.34428605
43MP0010678_abnormal_skin_adnexa1.34145379
44MP0004858_abnormal_nervous_system1.33193309
45MP0000467_abnormal_esophagus_morphology1.33133172
46MP0000733_abnormal_muscle_development1.32280273
47MP0010094_abnormal_chromosome_stability1.30490740
48MP0003806_abnormal_nucleotide_metabolis1.29328419
49* MP0002084_abnormal_developmental_patter1.29126752
50* MP0002085_abnormal_embryonic_tissue1.28954149
51MP0000678_abnormal_parathyroid_gland1.27868578
52MP0000762_abnormal_tongue_morphology1.27781065
53MP0002697_abnormal_eye_size1.26659005
54MP0001348_abnormal_lacrimal_gland1.26635152
55MP0003984_embryonic_growth_retardation1.26173797
56MP0002088_abnormal_embryonic_growth/wei1.23839274
57MP0002089_abnormal_postnatal_growth/wei1.23357714
58MP0003937_abnormal_limbs/digits/tail_de1.22317647
59MP0003115_abnormal_respiratory_system1.20768664
60MP0001216_abnormal_epidermal_layer1.17725683
61MP0005451_abnormal_body_composition1.17674247
62MP0000627_abnormal_mammary_gland1.17412958
63MP0000003_abnormal_adipose_tissue1.16582134
64MP0003890_abnormal_embryonic-extraembry1.15832341
65MP0000383_abnormal_hair_follicle1.14983249
66MP0003191_abnormal_cellular_cholesterol1.14660479
67MP0008932_abnormal_embryonic_tissue1.13737354
68MP0003283_abnormal_digestive_organ1.12812112
69MP0002234_abnormal_pharynx_morphology1.12496692
70MP0005367_renal/urinary_system_phenotyp1.12212444
71MP0000516_abnormal_urinary_system1.12212444
72MP0003315_abnormal_perineum_morphology1.12076001
73MP0003385_abnormal_body_wall1.11562291
74MP0008057_abnormal_DNA_replication1.11521503
75MP0002098_abnormal_vibrissa_morphology1.11127997
76MP0002896_abnormal_bone_mineralization1.10444063
77MP0005197_abnormal_uvea_morphology1.10291095
78MP0000566_synostosis1.09824976
79MP0003279_aneurysm1.09158430
80MP0001697_abnormal_embryo_size1.08950988
81MP0003786_premature_aging1.08869149
82MP0001915_intracranial_hemorrhage1.08568182
83MP0009780_abnormal_chondrocyte_physiolo1.08137784
84MP0004233_abnormal_muscle_weight1.07515075
85MP0001286_abnormal_eye_development1.06849013
86* MP0002925_abnormal_cardiovascular_devel1.03701052
87MP0005248_abnormal_Harderian_gland1.03700721
88MP0010368_abnormal_lymphatic_system1.03258273
89MP0000432_abnormal_head_morphology1.02258019
90MP0004782_abnormal_surfactant_physiolog1.01731805
91* MP0002111_abnormal_tail_morphology1.01420462
92MP0002092_abnormal_eye_morphology1.01039548
93MP0003950_abnormal_plasma_membrane1.00182188
94MP0000490_abnormal_crypts_of0.98799766
95MP0001243_abnormal_dermal_layer0.98745632
96MP0006054_spinal_hemorrhage0.98019839
97MP0001293_anophthalmia0.96862614
98MP0002080_prenatal_lethality0.96571914
99MP0000428_abnormal_craniofacial_morphol0.95817785
100MP0001299_abnormal_eye_distance/0.95264654
101* MP0000858_altered_metastatic_potential0.92647917
102MP0000013_abnormal_adipose_tissue0.92187733
103MP0000534_abnormal_ureter_morphology0.90251657
104MP0001879_abnormal_lymphatic_vessel0.89497939
105MP0009840_abnormal_foam_cell0.89378721
106MP0005508_abnormal_skeleton_morphology0.88105179
107MP0000477_abnormal_intestine_morphology0.87403178
108MP0001340_abnormal_eyelid_morphology0.87346509
109MP0000767_abnormal_smooth_muscle0.86999151
110MP0003755_abnormal_palate_morphology0.86299018
111MP0002282_abnormal_trachea_morphology0.85461389
112MP0005377_hearing/vestibular/ear_phenot0.85124618
113MP0003878_abnormal_ear_physiology0.85124618
114MP0005621_abnormal_cell_physiology0.84526889
115MP0010771_integument_phenotype0.83866013
116MP0003936_abnormal_reproductive_system0.83417769
117MP0001958_emphysema0.83272792
118MP0008260_abnormal_autophagy0.83253542
119MP0003942_abnormal_urinary_system0.82870230
120MP0005360_urolithiasis0.82149760
121MP0009384_cardiac_valve_regurgitation0.82063800
122MP0000462_abnormal_digestive_system0.82055561
123MP0000749_muscle_degeneration0.81916115
124MP0003448_altered_tumor_morphology0.81734727
125MP0003935_abnormal_craniofacial_develop0.81232124
126MP0003045_fibrosis0.80465969
127MP0002233_abnormal_nose_morphology0.79674518
128MP0005257_abnormal_intraocular_pressure0.79041300
129MP0000377_abnormal_hair_follicle0.78279386
130* MP0001614_abnormal_blood_vessel0.78248408
131MP0001191_abnormal_skin_condition0.77602758
132MP0009931_abnormal_skin_appearance0.74079027
133MP0005083_abnormal_biliary_tract0.74073750
134MP0005375_adipose_tissue_phenotype0.72749671

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)4.16897578
2Milia (HP:0001056)3.88926370
3Onycholysis (HP:0001806)3.33105171
4Premature rupture of membranes (HP:0001788)3.28943558
5Protrusio acetabuli (HP:0003179)3.21125020
6Arterial tortuosity (HP:0005116)3.13592730
7Shallow orbits (HP:0000586)2.98149224
8Thick nail (HP:0001805)2.90577761
9Selective tooth agenesis (HP:0001592)2.83372411
10Hyperacusis (HP:0010780)2.78112433
11Esophageal atresia (HP:0002032)2.76631645
12Ependymoma (HP:0002888)2.74455946
13Vascular tortuosity (HP:0004948)2.72598332
14Fused cervical vertebrae (HP:0002949)2.69753395
15Nail dystrophy (HP:0008404)2.69459737
16Missing ribs (HP:0000921)2.69059063
17Ulnar bowing (HP:0003031)2.65941051
18Cervical subluxation (HP:0003308)2.65532069
19Vertebral clefting (HP:0008428)2.65282663
20Natal tooth (HP:0000695)2.63950952
21Right ventricular cardiomyopathy (HP:0011663)2.57846460
22Spinal rigidity (HP:0003306)2.55182818
23Abnormality of oral frenula (HP:0000190)2.54710344
24Alopecia of scalp (HP:0002293)2.54347650
25Flat acetabular roof (HP:0003180)2.52957204
26Short humerus (HP:0005792)2.50845394
27Radial bowing (HP:0002986)2.49349979
28Ankyloglossia (HP:0010296)2.48989229
29Aplasia/hypoplasia of the humerus (HP:0006507)2.45471658
30Vertebral compression fractures (HP:0002953)2.44277519
31Distal lower limb muscle weakness (HP:0009053)2.44027475
32Deviation of the thumb (HP:0009603)2.43677771
33Cerebral aneurysm (HP:0004944)2.41622207
34Abnormality of the astrocytes (HP:0100707)2.40516355
35Astrocytoma (HP:0009592)2.40516355
3611 pairs of ribs (HP:0000878)2.38827990
37Abnormality of nail color (HP:0100643)2.37315429
38Short nail (HP:0001799)2.37208982
39Entropion (HP:0000621)2.37044552
40Fragile nails (HP:0001808)2.35458635
41Abnormality of the calcaneus (HP:0008364)2.35367373
42Achilles tendon contracture (HP:0001771)2.33990158
43Fragile skin (HP:0001030)2.33841659
44Bowing of the arm (HP:0006488)2.33106941
45Bowed forearm bones (HP:0003956)2.33106941
46Vertebral hypoplasia (HP:0008417)2.32140576
47Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.32140576
48Increased connective tissue (HP:0009025)2.31058268
49Focal segmental glomerulosclerosis (HP:0000097)2.26237036
50Abnormal vertebral ossification (HP:0100569)2.25592577
51Ridged nail (HP:0001807)2.22668759
52Wrist flexion contracture (HP:0001239)2.20983441
53Lower limb amyotrophy (HP:0007210)2.17712602
54Absent radius (HP:0003974)2.16903951
55Advanced eruption of teeth (HP:0006288)2.12646458
56Abnormal ossification of hand bones (HP:0005921)2.11852646
57Aortic dissection (HP:0002647)2.11494633
58Abnormality of the Achilles tendon (HP:0005109)2.11001422
59Ankle contracture (HP:0006466)2.10639662
60Biliary tract neoplasm (HP:0100574)2.10613988
61Plantar hyperkeratosis (HP:0007556)2.10457295
62Reduced subcutaneous adipose tissue (HP:0003758)2.10284683
63Aplasia involving forearm bones (HP:0009822)2.08737407
64Absent forearm bone (HP:0003953)2.08737407
65Abnormality of the nasal septum (HP:0000419)2.08463610
66Abnormality of carpal bone ossification (HP:0006257)2.07449398
67Mildly elevated creatine phosphokinase (HP:0008180)2.07428836
68Aplasia cutis congenita (HP:0001057)2.04545845
69Trismus (HP:0000211)2.03237631
70Wormian bones (HP:0002645)2.02543845
71Abnormality of the labia minora (HP:0012880)2.01928097
72Tibial bowing (HP:0002982)2.00991063
73Abnormality of the distal phalanx of the thumb (HP:0009617)2.00778191
74Palmoplantar hyperkeratosis (HP:0000972)1.98780208
75Abnormality of the proximal phalanges of the hand (HP:0009834)1.98542042
76Broad face (HP:0000283)1.97406549
77Elbow flexion contracture (HP:0002987)1.97378367
78Interstitial pulmonary disease (HP:0006530)1.96584602
79Increased mean platelet volume (HP:0011877)1.95597105
80Bronchomalacia (HP:0002780)1.94586699
81Vertebral fusion (HP:0002948)1.91072226
82Metaphyseal cupping (HP:0003021)1.90053706
83Abnormal blistering of the skin (HP:0008066)1.89162759
84Acanthosis nigricans (HP:0000956)1.88313608
85Neoplasm of the oral cavity (HP:0100649)1.87183245
86Distal lower limb amyotrophy (HP:0008944)1.87106821
87Glomerulosclerosis (HP:0000096)1.85466887
88Cardiovascular calcification (HP:0011915)1.84641119
89Proximal placement of thumb (HP:0009623)1.84469835
90Bladder diverticulum (HP:0000015)1.84377972
91Esophageal varix (HP:0002040)1.84333550
92Palmar hyperkeratosis (HP:0010765)1.84249027
93Poikiloderma (HP:0001029)1.84068812
94Genu recurvatum (HP:0002816)1.83454158
95Mitral regurgitation (HP:0001653)1.83231315
96Urethral obstruction (HP:0000796)1.82468782
97Abnormality of the acetabulum (HP:0003170)1.82049407
98Gastrointestinal carcinoma (HP:0002672)1.81505986
99Malignant gastrointestinal tract tumors (HP:0006749)1.81505986
100Vascular calcification (HP:0004934)1.81410208
101Vertebral arch anomaly (HP:0008438)1.80794951
102Rib fusion (HP:0000902)1.80074686
103Insomnia (HP:0100785)1.79014373
104Sparse eyelashes (HP:0000653)1.77847841
105Glucose intolerance (HP:0000833)1.77791150
106Long palpebral fissure (HP:0000637)1.77630726
107Pterygium (HP:0001059)1.77468399
108Upper limb amyotrophy (HP:0009129)1.77462800
109Distal upper limb amyotrophy (HP:0007149)1.77462800
110Glioma (HP:0009733)1.76462106
111Disproportionate tall stature (HP:0001519)1.75996927
112Coxa vara (HP:0002812)1.75585427
113Neonatal death (HP:0003811)1.75389781
114Deep venous thrombosis (HP:0002625)1.75202215
115Limb-girdle muscle atrophy (HP:0003797)1.74844179
116Abnormality of the umbilical cord (HP:0010881)1.73955452
117Aplasia involving bones of the upper limbs (HP:0009823)1.73685117
118Aplasia of the phalanges of the hand (HP:0009802)1.73685117
119Aplasia involving bones of the extremities (HP:0009825)1.73685117
120Spinal cord compression (HP:0002176)1.73297610
121Spastic diplegia (HP:0001264)1.72720929
122Skull defect (HP:0001362)1.71732032
123Gastrointestinal atresia (HP:0002589)1.71686747
124Abnormality of dentin (HP:0010299)1.71458230
125Stillbirth (HP:0003826)1.71206907
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71128241
127Hydroureter (HP:0000072)1.70994025
128Abnormality of the distal phalanges of the toes (HP:0010182)1.70104157
129Shawl scrotum (HP:0000049)1.65668833
130Mesomelia (HP:0003027)1.65411634
131Hypoplastic ischia (HP:0003175)1.65081945
132Peritonitis (HP:0002586)1.63973663
133Rectal prolapse (HP:0002035)1.63402511
134Hand muscle atrophy (HP:0009130)1.63334869
135Abnormal platelet volume (HP:0011876)1.62352793
136Pili torti (HP:0003777)1.61942429
137Chromosomal breakage induced by crosslinking agents (HP:0003221)1.61898696
138Difficulty climbing stairs (HP:0003551)1.61055729
139Osteolytic defects of the hand bones (HP:0009699)1.60915811
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.60915811
141Chromsome breakage (HP:0040012)1.60482611
142Hypoplasia of dental enamel (HP:0006297)1.59282092
143Fibular aplasia (HP:0002990)1.58785613
144Pseudobulbar signs (HP:0002200)1.58680385
145Synostosis of carpal bones (HP:0005048)1.57276011
146Blepharitis (HP:0000498)1.55707137
147Neonatal short-limb short stature (HP:0008921)1.55564959
148Limited elbow extension (HP:0001377)1.54793594
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.54358427
150Broad thumb (HP:0011304)1.54308659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.73863670
2* EPHA23.62894029
3LMTK23.18205761
4LATS13.02329387
5IRAK32.93605740
6RPS6KB22.87061325
7TTN2.61420504
8PAK42.28150041
9PKN22.15048433
10SMG12.08393622
11MST42.05290785
12STK102.02495886
13MET2.01217717
14NTRK11.92700249
15STK38L1.86742765
16RIPK11.86526279
17EEF2K1.80139758
18TTK1.74436004
19MAP3K101.70260723
20LATS21.67440240
21PTK21.66212029
22BMX1.65734941
23MAP3K31.64845681
24DDR21.60944425
25EPHB21.51165052
26CDK71.49881103
27STK31.49591520
28FER1.47305049
29TSSK61.42256351
30WEE11.39043053
31ERBB41.37546926
32PTK61.36374190
33MAP3K81.35536013
34PDGFRA1.35234588
35FLT31.33783649
36ERN11.31725224
37MST1R1.31601792
38MAP3K91.31547010
39CDK81.31329981
40BRD41.30992257
41NEK21.25497136
42CDC71.23627436
43RPS6KA41.22812184
44PIM21.22437278
45ZAK1.21522801
46PAK21.20970593
47LRRK21.20269101
48MTOR1.19645340
49TGFBR11.17979804
50ARAF1.15655238
51BUB11.15354433
52CDK61.14178192
53SIK11.12789316
54MAPKAPK31.10043103
55AURKB1.08321394
56TGFBR21.07359130
57CDK41.06647414
58LIMK11.05340754
59MAP2K21.04989220
60TRPM71.03344380
61PASK1.00681325
62MOS0.98620896
63FGFR10.95243905
64PRKCI0.91794330
65TLK10.90764393
66TESK10.90460275
67PBK0.90344986
68KDR0.88585304
69PLK10.88060170
70STK380.82549285
71NME20.82353212
72MATK0.80286881
73PRKG20.79322286
74CHEK10.79040387
75STK40.79005129
76ALK0.76973362
77PIM10.75551017
78TRIB30.71803117
79CHEK20.71531711
80MELK0.69471204
81ATR0.69363137
82ICK0.68828860
83NEK10.68786069
84SCYL20.67115156
85MYLK0.66683525
86CHUK0.66211257
87AURKA0.62759030
88MAP2K30.62523180
89BRSK10.62461031
90ROCK20.62200059
91PRKD20.62073376
92PLK30.61924772
93EPHB10.60100718
94ILK0.59914273
95FRK0.59441092
96MAP3K120.59417436
97MAP2K10.58446903
98SRPK10.58357409
99AKT30.57359153
100MAP3K60.56395090
101TAOK20.55601194
102ATM0.55142691
103PTK2B0.53534575
104AKT20.53193564
105CSNK1D0.52484142
106ABL20.51512271
107TIE10.50137192
108PDGFRB0.49631558
109PAK10.48619972
110MAP3K20.47633808
111DMPK0.47123109
112FGFR40.46608332
113DYRK30.46287277
114RPS6KA20.45653937
115CDK20.45095667
116INSR0.44280356
117BRAF0.44234262
118GSK3A0.42799230
119BRSK20.42299360
120EIF2AK10.42014177
121TESK20.41943959
122PRKD30.40719414
123CDK90.40708095
124IRAK20.40474079
125SIK30.40260851
126MAPK10.39590243
127DYRK1B0.39547961
128PHKG20.39216552
129PHKG10.39216552
130EGFR0.38042063
131ERBB20.37895535
132CSK0.37874992
133VRK10.37105223
134ROCK10.36796292
135STK240.35907087
136CDC42BPA0.34839374
137KSR10.27415401

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.79531967
2ECM-receptor interaction_Homo sapiens_hsa045122.77850881
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52523930
4Small cell lung cancer_Homo sapiens_hsa052222.42078119
5Adherens junction_Homo sapiens_hsa045202.40167327
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38856484
7Bladder cancer_Homo sapiens_hsa052192.33106640
8p53 signaling pathway_Homo sapiens_hsa041152.14673205
9Hippo signaling pathway_Homo sapiens_hsa043902.08216476
10RNA transport_Homo sapiens_hsa030131.93385775
11Mismatch repair_Homo sapiens_hsa034301.91991800
12MicroRNAs in cancer_Homo sapiens_hsa052061.85277984
13DNA replication_Homo sapiens_hsa030301.84198565
14Focal adhesion_Homo sapiens_hsa045101.82975984
15Basal cell carcinoma_Homo sapiens_hsa052171.81026576
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.75363195
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.73934542
18Proteoglycans in cancer_Homo sapiens_hsa052051.69584858
19Cell cycle_Homo sapiens_hsa041101.67634640
20TGF-beta signaling pathway_Homo sapiens_hsa043501.66456791
21Systemic lupus erythematosus_Homo sapiens_hsa053221.64396844
22Tight junction_Homo sapiens_hsa045301.56736524
23Spliceosome_Homo sapiens_hsa030401.56079643
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.55782804
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.52908347
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45933767
27Galactose metabolism_Homo sapiens_hsa000521.44116060
28Viral carcinogenesis_Homo sapiens_hsa052031.34588890
29N-Glycan biosynthesis_Homo sapiens_hsa005101.31557671
30Amoebiasis_Homo sapiens_hsa051461.29074598
31Selenocompound metabolism_Homo sapiens_hsa004501.27414406
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.25022838
33Notch signaling pathway_Homo sapiens_hsa043301.16252253
34Nucleotide excision repair_Homo sapiens_hsa034201.15943932
35Hedgehog signaling pathway_Homo sapiens_hsa043401.14839165
36Fructose and mannose metabolism_Homo sapiens_hsa000511.12569303
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11485008
38* Axon guidance_Homo sapiens_hsa043601.07455070
39Thyroid cancer_Homo sapiens_hsa052161.05479538
40Pathways in cancer_Homo sapiens_hsa052001.05393457
41HTLV-I infection_Homo sapiens_hsa051661.04834875
42* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03234024
43Prion diseases_Homo sapiens_hsa050201.02737534
44Base excision repair_Homo sapiens_hsa034101.01836865
45ErbB signaling pathway_Homo sapiens_hsa040121.01552256
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00272509
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99948031
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99593515
49mRNA surveillance pathway_Homo sapiens_hsa030150.99259785
50Fanconi anemia pathway_Homo sapiens_hsa034600.97783877
51Renal cell carcinoma_Homo sapiens_hsa052110.96778532
52Chronic myeloid leukemia_Homo sapiens_hsa052200.96359147
53Non-homologous end-joining_Homo sapiens_hsa034500.96022787
54Melanoma_Homo sapiens_hsa052180.93274793
55Apoptosis_Homo sapiens_hsa042100.92865667
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92711885
57Sulfur relay system_Homo sapiens_hsa041220.92093081
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90245781
59Vitamin B6 metabolism_Homo sapiens_hsa007500.90141512
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87841573
61Homologous recombination_Homo sapiens_hsa034400.86932481
62Glioma_Homo sapiens_hsa052140.84555591
63Vibrio cholerae infection_Homo sapiens_hsa051100.84400765
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.84288472
65Protein digestion and absorption_Homo sapiens_hsa049740.83412077
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83392890
67Prostate cancer_Homo sapiens_hsa052150.81023757
68VEGF signaling pathway_Homo sapiens_hsa043700.80420282
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.79860368
70Phenylalanine metabolism_Homo sapiens_hsa003600.77928843
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77126460
72Viral myocarditis_Homo sapiens_hsa054160.76391063
73Lysine degradation_Homo sapiens_hsa003100.76234967
74Endocytosis_Homo sapiens_hsa041440.76189882
75Insulin signaling pathway_Homo sapiens_hsa049100.76167042
76Toxoplasmosis_Homo sapiens_hsa051450.75482729
77RNA polymerase_Homo sapiens_hsa030200.75313127
78Shigellosis_Homo sapiens_hsa051310.75177924
79Complement and coagulation cascades_Homo sapiens_hsa046100.75146700
80Ribosome_Homo sapiens_hsa030100.75063034
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71999485
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71755904
83Other glycan degradation_Homo sapiens_hsa005110.70746803
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70390204
85RNA degradation_Homo sapiens_hsa030180.68403241
86Non-small cell lung cancer_Homo sapiens_hsa052230.68126678
87Hematopoietic cell lineage_Homo sapiens_hsa046400.67570206
88Vitamin digestion and absorption_Homo sapiens_hsa049770.66510016
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66027333
90Wnt signaling pathway_Homo sapiens_hsa043100.65953440
91Biosynthesis of amino acids_Homo sapiens_hsa012300.65860150
92Sphingolipid metabolism_Homo sapiens_hsa006000.65356371
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65265308
94HIF-1 signaling pathway_Homo sapiens_hsa040660.64985393
95Carbon metabolism_Homo sapiens_hsa012000.63995781
96Pyrimidine metabolism_Homo sapiens_hsa002400.63678865
97Melanogenesis_Homo sapiens_hsa049160.61107015
98Pancreatic cancer_Homo sapiens_hsa052120.60687632
99Glutathione metabolism_Homo sapiens_hsa004800.60213076
100Endometrial cancer_Homo sapiens_hsa052130.59937478
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59328893
102Colorectal cancer_Homo sapiens_hsa052100.58450991
103Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56399253
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55668409
105Renin-angiotensin system_Homo sapiens_hsa046140.55626121
106Chemical carcinogenesis_Homo sapiens_hsa052040.54389190
107Legionellosis_Homo sapiens_hsa051340.53681450
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53289551
109TNF signaling pathway_Homo sapiens_hsa046680.53245264
110AMPK signaling pathway_Homo sapiens_hsa041520.52884129
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.52702045
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52222057
113Mineral absorption_Homo sapiens_hsa049780.52085957
114Inositol phosphate metabolism_Homo sapiens_hsa005620.51872701
115Epstein-Barr virus infection_Homo sapiens_hsa051690.51551290
116Fat digestion and absorption_Homo sapiens_hsa049750.51285673
117Malaria_Homo sapiens_hsa051440.50124634
118Basal transcription factors_Homo sapiens_hsa030220.50108026
119* Rap1 signaling pathway_Homo sapiens_hsa040150.49681109
120Folate biosynthesis_Homo sapiens_hsa007900.48596693
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.48577534
122Hepatitis C_Homo sapiens_hsa051600.47540001
123Salmonella infection_Homo sapiens_hsa051320.46997135
124Thyroid hormone synthesis_Homo sapiens_hsa049180.45771812
125Herpes simplex infection_Homo sapiens_hsa051680.45712985
126Hepatitis B_Homo sapiens_hsa051610.44792830
127Glucagon signaling pathway_Homo sapiens_hsa049220.44603973
128Insulin resistance_Homo sapiens_hsa049310.43947287
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.43933145
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42767276
131Acute myeloid leukemia_Homo sapiens_hsa052210.42316766
132Pentose phosphate pathway_Homo sapiens_hsa000300.42040128
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.41142329
134Bile secretion_Homo sapiens_hsa049760.40657967
135Antigen processing and presentation_Homo sapiens_hsa046120.37784821
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37610118
137Arginine biosynthesis_Homo sapiens_hsa002200.37573008
138Dilated cardiomyopathy_Homo sapiens_hsa054140.36427345
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35931471

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