EPHA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.37196704
2nucleobase catabolic process (GO:0046113)5.54584102
3postsynaptic membrane organization (GO:0001941)5.12210414
4* axonal fasciculation (GO:0007413)5.03398088
5axon extension involved in axon guidance (GO:0048846)5.02484001
6neuron projection extension involved in neuron projection guidance (GO:1902284)5.02484001
7regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.69466119
8retinal ganglion cell axon guidance (GO:0031290)4.39955673
9central nervous system projection neuron axonogenesis (GO:0021952)4.22404943
10vocalization behavior (GO:0071625)4.18013789
11response to pheromone (GO:0019236)4.14314255
12head development (GO:0060322)4.08057723
13* neuron recognition (GO:0008038)4.03460968
14respiratory tube development (GO:0030323)4.02166237
15negative regulation of axon extension involved in axon guidance (GO:0048843)3.97955224
16calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.93719404
17mesenchymal cell differentiation involved in kidney development (GO:0072161)3.92342266
18mesenchymal cell differentiation involved in renal system development (GO:2001012)3.92342266
19negative regulation of catenin import into nucleus (GO:0035414)3.91668827
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.89062806
21auditory behavior (GO:0031223)3.88441383
22positive regulation of mitochondrial fission (GO:0090141)3.82038016
23regulation of non-canonical Wnt signaling pathway (GO:2000050)3.80906266
24neurotransmitter-gated ion channel clustering (GO:0072578)3.76976284
25negative regulation of axon guidance (GO:1902668)3.73179962
26synapse assembly (GO:0007416)3.72786463
27chondrocyte proliferation (GO:0035988)3.70290486
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70251586
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.65406335
30craniofacial suture morphogenesis (GO:0097094)3.63777693
31negative regulation of oligodendrocyte differentiation (GO:0048715)3.62559523
32establishment of mitochondrion localization (GO:0051654)3.61011803
33bone trabecula formation (GO:0060346)3.60670947
34olfactory bulb development (GO:0021772)3.57025476
35metanephric mesenchyme development (GO:0072075)3.54108055
36lateral sprouting from an epithelium (GO:0060601)3.53166394
37midgut development (GO:0007494)3.52825485
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51959076
39negative chemotaxis (GO:0050919)3.48809592
40presynaptic membrane organization (GO:0097090)3.45823653
41forebrain neuron differentiation (GO:0021879)3.43085278
42mechanosensory behavior (GO:0007638)3.42927011
43cerebral cortex radially oriented cell migration (GO:0021799)3.42105936
44intraciliary transport (GO:0042073)3.41329114
45kidney mesenchyme development (GO:0072074)3.38493655
46central nervous system neuron axonogenesis (GO:0021955)3.36807771
47hippocampus development (GO:0021766)3.32023890
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.28107273
49cell migration in hindbrain (GO:0021535)3.27845836
50nonmotile primary cilium assembly (GO:0035058)3.27595552
51mesenchymal-epithelial cell signaling (GO:0060638)3.27286835
52regulation of axon extension involved in axon guidance (GO:0048841)3.26813173
53sequestering of extracellular ligand from receptor (GO:0035581)3.25851489
54limb bud formation (GO:0060174)3.24260456
55transmission of nerve impulse (GO:0019226)3.23618967
56chondrocyte development (GO:0002063)3.20750350
57hippo signaling (GO:0035329)3.19830848
58regulation of axon guidance (GO:1902667)3.19151774
59substrate-independent telencephalic tangential migration (GO:0021826)3.17841123
60substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.17841123
61regulation of catenin import into nucleus (GO:0035412)3.17767663
62positive regulation of synapse maturation (GO:0090129)3.17371176
63ganglion development (GO:0061548)3.17342705
64negative regulation of osteoblast proliferation (GO:0033689)3.16321551
65cell proliferation involved in metanephros development (GO:0072203)3.15882761
66gamma-aminobutyric acid transport (GO:0015812)3.15764615
67layer formation in cerebral cortex (GO:0021819)3.15568477
68polarized epithelial cell differentiation (GO:0030859)3.14219937
69pyrimidine nucleobase catabolic process (GO:0006208)3.11323542
70melanin biosynthetic process (GO:0042438)3.10237266
71response to auditory stimulus (GO:0010996)3.09834780
72spinal cord development (GO:0021510)3.08672387
73neuronal stem cell maintenance (GO:0097150)3.06984661
74protein localization to cilium (GO:0061512)3.04377866
75lung vasculature development (GO:0060426)3.03848198
76neuron migration (GO:0001764)3.01477961
77mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.01123943
78embryonic digestive tract morphogenesis (GO:0048557)3.00900013
79cell proliferation in forebrain (GO:0021846)3.00824969
80semaphorin-plexin signaling pathway (GO:0071526)2.99955824
81middle ear morphogenesis (GO:0042474)2.99750665
82paraxial mesoderm development (GO:0048339)2.98863566
83heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.98119503
84camera-type eye morphogenesis (GO:0048593)2.97945991
85convergent extension (GO:0060026)2.97127977
86Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.97081885
87insulin-like growth factor receptor signaling pathway (GO:0048009)2.96197772
88appendage development (GO:0048736)2.94603306
89limb development (GO:0060173)2.94603306
90synapse organization (GO:0050808)2.93576506
91regulation of mesenchymal cell proliferation (GO:0010464)2.93188347
92neural tube formation (GO:0001841)2.92813064
93embryonic cranial skeleton morphogenesis (GO:0048701)2.91881392
94somite development (GO:0061053)2.91708582
95negative regulation of stem cell proliferation (GO:2000647)2.89685600
96positive regulation of dendritic spine morphogenesis (GO:0061003)2.89043440
97behavioral response to nicotine (GO:0035095)2.88975327
98hindlimb morphogenesis (GO:0035137)2.88000986
99melanin metabolic process (GO:0006582)2.87536215
100mesenchymal cell proliferation (GO:0010463)2.87408680
101positive regulation of catenin import into nucleus (GO:0035413)2.86927140
102regulation of establishment of planar polarity (GO:0090175)2.86681464
103collagen fibril organization (GO:0030199)2.85145889
104axon extension (GO:0048675)2.83921493
105regulation of development, heterochronic (GO:0040034)2.83553245
106neuron fate determination (GO:0048664)2.83016845
107dendrite morphogenesis (GO:0048813)2.81267729
108positive regulation of mesenchymal cell proliferation (GO:0002053)2.80779706
109embryonic hindlimb morphogenesis (GO:0035116)2.78307790
110cranial nerve morphogenesis (GO:0021602)2.78002304
111positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77931334
112establishment of nucleus localization (GO:0040023)2.77104175
113body morphogenesis (GO:0010171)2.76330689
114positive regulation of gastrulation (GO:2000543)2.75543252
115dendritic spine morphogenesis (GO:0060997)2.74624228
116axonogenesis (GO:0007409)2.74554664
117endocardial cushion development (GO:0003197)2.73492336
118regulation of oligodendrocyte differentiation (GO:0048713)2.72972704
119negative regulation of chondrocyte differentiation (GO:0032331)2.72806894
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71865269
121cardiac left ventricle morphogenesis (GO:0003214)2.71706778
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.70832381
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67004087
124mitochondrion transport along microtubule (GO:0047497)2.67004087
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.65577698
126mesenchymal cell differentiation (GO:0048762)2.64834266
127protein localization to synapse (GO:0035418)2.64544157
128cranial suture morphogenesis (GO:0060363)2.64427976
129palate development (GO:0060021)2.64283578
130positive regulation of dendrite morphogenesis (GO:0050775)2.63774668
131cell differentiation involved in kidney development (GO:0061005)2.62861568
132mesenchyme development (GO:0060485)2.62092020
133regulation of timing of cell differentiation (GO:0048505)2.61758420
134epithelial cell differentiation involved in kidney development (GO:0035850)2.61397087
135cerebral cortex cell migration (GO:0021795)2.61238830
136homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.61063622
137regulation of synapse maturation (GO:0090128)2.61027266
138sequestering of actin monomers (GO:0042989)2.61011917
139regulation of synapse assembly (GO:0051963)2.60416482
140extracellular matrix assembly (GO:0085029)2.60213952
141startle response (GO:0001964)2.59775745
142neuron cell-cell adhesion (GO:0007158)2.59147056
143positive regulation of synapse assembly (GO:0051965)2.58857875
144negative regulation of embryonic development (GO:0045992)2.57348072
145* ephrin receptor signaling pathway (GO:0048013)2.56973236
146cell proliferation involved in kidney development (GO:0072111)2.56855050
147membrane assembly (GO:0071709)2.56684921
148regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.55227719
149cartilage morphogenesis (GO:0060536)2.55003586
150sympathetic nervous system development (GO:0048485)2.54794135
151regulation of synaptic transmission, glutamatergic (GO:0051966)2.54444302
152embryonic foregut morphogenesis (GO:0048617)2.54214973
153regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53951799
154negative regulation of axon extension (GO:0030517)2.53530080
155regulation of feeding behavior (GO:0060259)2.53247295
156neuronal ion channel clustering (GO:0045161)2.52823375
157regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.50953741
158lung morphogenesis (GO:0060425)2.50904291
159regulation of neuron migration (GO:2001222)2.50747475
160neuronal action potential propagation (GO:0019227)2.48434024
161cellular response to cholesterol (GO:0071397)2.48050527
162regulation of synapse organization (GO:0050807)2.47965510
163synaptic transmission, glutamatergic (GO:0035249)2.47017628
164cardiac ventricle formation (GO:0003211)2.46337491
165short-term memory (GO:0007614)2.46307291
166glutamate receptor signaling pathway (GO:0007215)2.45082651
167positive regulation of cardiac muscle cell differentiation (GO:2000727)2.44967282
168adult walking behavior (GO:0007628)2.43719970
169glial cell proliferation (GO:0014009)2.43562528
170regulation of glutamate receptor signaling pathway (GO:1900449)2.41895894
171dendrite development (GO:0016358)2.40653237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19944851
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.65442896
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52202477
4GBX2_23144817_ChIP-Seq_PC3_Human3.24439140
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.01132013
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.97711844
7* EED_16625203_ChIP-ChIP_MESCs_Mouse2.81563366
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75065935
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69939656
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69939656
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61174947
12* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59460366
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.50128177
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48521879
15RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.47225649
16* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.46433276
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45961616
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41150346
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.38519661
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.36515301
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34502633
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28767680
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.99335558
24PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.98269330
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.97282146
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91807406
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.85653092
28* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80219299
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.79401334
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78509469
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77789338
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75621239
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.75101682
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74503155
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.68983348
36* AR_21572438_ChIP-Seq_LNCaP_Human1.68766226
37VDR_22108803_ChIP-Seq_LS180_Human1.67959895
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.64008074
39ZNF274_21170338_ChIP-Seq_K562_Hela1.63349544
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60869354
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.60814459
42* P300_19829295_ChIP-Seq_ESCs_Human1.57704136
43FUS_26573619_Chip-Seq_HEK293_Human1.55995403
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54293586
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53915423
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53526869
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53241867
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52138578
49RNF2_27304074_Chip-Seq_NSC_Mouse1.51773695
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51086201
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.50275871
52EWS_26573619_Chip-Seq_HEK293_Human1.49008847
53* TP53_18474530_ChIP-ChIP_U2OS_Human1.48870687
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.46578907
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44777187
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.44206531
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.40486201
58SMAD4_21799915_ChIP-Seq_A2780_Human1.40454444
59TAF15_26573619_Chip-Seq_HEK293_Human1.38893830
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38408267
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38408267
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38081000
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36533998
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35244941
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30782960
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29599052
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28078115
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.27880057
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23636679
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23415808
71* ER_23166858_ChIP-Seq_MCF-7_Human1.22474162
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22391546
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22333432
74KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22330513
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.21915864
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.20619173
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18948114
78DROSHA_22980978_ChIP-Seq_HELA_Human1.17489623
79FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17046033
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16866843
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.16719772
82CBP_20019798_ChIP-Seq_JUKART_Human1.16296476
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16296476
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15713148
85FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15012742
86* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14620937
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.14596351
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14532188
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13037373
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12579969
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12211827
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11096668
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10237996
94* TCF4_23295773_ChIP-Seq_U87_Human1.10146884
95* SOX2_21211035_ChIP-Seq_LN229_Gbm1.09587155
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09434735
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09254740
98* AR_25329375_ChIP-Seq_VCAP_Human1.09218616
99* AR_19668381_ChIP-Seq_PC3_Human1.08140691
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07265526
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06938143
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06206723
103BCAT_22108803_ChIP-Seq_LS180_Human1.04891925
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04532643
105* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03899820
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03623067
107SOX9_26525672_Chip-Seq_HEART_Mouse1.02815312
108RUNX2_22187159_ChIP-Seq_PCA_Human1.02263024
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01283702
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00217231
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00211030
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00019818
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.98742312
114* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98522633
115REST_21632747_ChIP-Seq_MESCs_Mouse0.98502994
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97967925
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.97808286
118* IGF1R_20145208_ChIP-Seq_DFB_Human0.97476688
119STAT3_23295773_ChIP-Seq_U87_Human0.95248821
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95068197
121AHR_22903824_ChIP-Seq_MCF-7_Human0.94564459
122* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94459936
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94379147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.71031616
2MP0010030_abnormal_orbit_morphology3.32096876
3MP0002822_catalepsy3.09068544
4MP0008438_abnormal_cutaneous_collagen3.06887579
5MP0003122_maternal_imprinting2.72376363
6MP0003385_abnormal_body_wall2.66743552
7MP0005171_absent_coat_pigmentation2.65530692
8MP0003136_yellow_coat_color2.64419205
9MP0004270_analgesia2.63800019
10MP0005248_abnormal_Harderian_gland2.45137999
11MP0003942_abnormal_urinary_system2.39978225
12MP0000778_abnormal_nervous_system2.37623707
13MP0000566_synostosis2.29944377
14MP0005423_abnormal_somatic_nervous2.29732710
15MP0009250_abnormal_appendicular_skeleto2.26045811
16MP0003880_abnormal_central_pattern2.22764398
17MP0004859_abnormal_synaptic_plasticity2.21641944
18MP0001529_abnormal_vocalization2.18335598
19MP0000049_abnormal_middle_ear2.16762748
20MP0000534_abnormal_ureter_morphology2.09849103
21MP0002938_white_spotting2.07105533
22MP0003755_abnormal_palate_morphology2.04429317
23MP0003123_paternal_imprinting2.00347187
24MP0002249_abnormal_larynx_morphology2.00173143
25MP0003121_genomic_imprinting1.98339893
26MP0005257_abnormal_intraocular_pressure1.97406065
27MP0003937_abnormal_limbs/digits/tail_de1.97104871
28MP0005275_abnormal_skin_tensile1.94782112
29MP0000537_abnormal_urethra_morphology1.94271149
30MP0009053_abnormal_anal_canal1.93305647
31MP0001984_abnormal_olfaction1.92883620
32MP0002282_abnormal_trachea_morphology1.87679188
33MP0002102_abnormal_ear_morphology1.83982747
34MP0002735_abnormal_chemical_nociception1.75589930
35MP0000372_irregular_coat_pigmentation1.72381574
36MP0000569_abnormal_digit_pigmentation1.67077402
37MP0003935_abnormal_craniofacial_develop1.65179049
38MP0000762_abnormal_tongue_morphology1.61988727
39MP0002734_abnormal_mechanical_nocicepti1.58954171
40MP0002638_abnormal_pupillary_reflex1.58806030
41MP0002233_abnormal_nose_morphology1.58400841
42MP0002572_abnormal_emotion/affect_behav1.55683223
43MP0003119_abnormal_digestive_system1.49272566
44MP0003115_abnormal_respiratory_system1.48997004
45MP0002234_abnormal_pharynx_morphology1.48516892
46MP0002272_abnormal_nervous_system1.48218854
47MP0009745_abnormal_behavioral_response1.47728038
48MP0001486_abnormal_startle_reflex1.47366263
49MP0004134_abnormal_chest_morphology1.46304588
50MP0003938_abnormal_ear_development1.46261540
51MP0002116_abnormal_craniofacial_bone1.45878358
52MP0005508_abnormal_skeleton_morphology1.42017149
53MP0002932_abnormal_joint_morphology1.41833211
54MP0003705_abnormal_hypodermis_morpholog1.40235476
55MP0002653_abnormal_ependyma_morphology1.39385869
56MP0001346_abnormal_lacrimal_gland1.39302044
57MP0002009_preneoplasia1.37871878
58MP0009046_muscle_twitch1.37789126
59MP0002184_abnormal_innervation1.37064830
60MP0000631_abnormal_neuroendocrine_gland1.36948794
61MP0001299_abnormal_eye_distance/1.36493756
62MP0002557_abnormal_social/conspecific_i1.35963523
63MP0004142_abnormal_muscle_tone1.35098549
64MP0002752_abnormal_somatic_nervous1.33763874
65MP0008789_abnormal_olfactory_epithelium1.31930916
66MP0000516_abnormal_urinary_system1.30757651
67MP0005367_renal/urinary_system_phenotyp1.30757651
68MP0005253_abnormal_eye_physiology1.30202626
69MP0005187_abnormal_penis_morphology1.29501190
70MP0002064_seizures1.28325746
71MP0004885_abnormal_endolymph1.26370520
72MP0000428_abnormal_craniofacial_morphol1.25355556
73MP0001293_anophthalmia1.23762840
74MP0006072_abnormal_retinal_apoptosis1.23374872
75MP0004272_abnormal_basement_membrane1.22195683
76MP0002067_abnormal_sensory_capabilities1.20947977
77MP0000647_abnormal_sebaceous_gland1.20717020
78MP0003890_abnormal_embryonic-extraembry1.20440529
79MP0005386_behavior/neurological_phenoty1.17226820
80MP0004924_abnormal_behavior1.17226820
81MP0002109_abnormal_limb_morphology1.17023782
82MP0001270_distended_abdomen1.16774579
83MP0001968_abnormal_touch/_nociception1.14525520
84MP0002177_abnormal_outer_ear1.14523205
85MP0002697_abnormal_eye_size1.12462477
86MP0004133_heterotaxia1.10118566
87MP0003635_abnormal_synaptic_transmissio1.09961498
88MP0000432_abnormal_head_morphology1.09285784
89MP0003861_abnormal_nervous_system1.09025373
90MP0001485_abnormal_pinna_reflex1.08954008
91MP0003787_abnormal_imprinting1.08303228
92MP0002108_abnormal_muscle_morphology1.07343350
93MP0004233_abnormal_muscle_weight1.07045057
94MP0000733_abnormal_muscle_development1.06630332
95MP0005195_abnormal_posterior_eye1.05498839
96MP0001958_emphysema1.05188793
97MP0001970_abnormal_pain_threshold1.04788251
98MP0005551_abnormal_eye_electrophysiolog1.04674337
99MP0000163_abnormal_cartilage_morphology1.04356920
100MP0000955_abnormal_spinal_cord1.00151344
101MP0002736_abnormal_nociception_after0.99866333
102MP0005623_abnormal_meninges_morphology0.99136671
103* MP0002081_perinatal_lethality0.98052975
104MP0002896_abnormal_bone_mineralization0.98005076
105MP0002063_abnormal_learning/memory/cond0.97991519
106MP0005408_hypopigmentation0.97298570
107MP0005391_vision/eye_phenotype0.96588933
108MP0004742_abnormal_vestibular_system0.96156626
109MP0001286_abnormal_eye_development0.96125024
110MP0006292_abnormal_olfactory_placode0.95862314
111MP0003315_abnormal_perineum_morphology0.94779674
112MP0006276_abnormal_autonomic_nervous0.93069639
113MP0002115_abnormal_skeleton_extremities0.92490435
114MP0001188_hyperpigmentation0.92057231
115MP0001340_abnormal_eyelid_morphology0.91724361
116MP0001502_abnormal_circadian_rhythm0.91553102
117MP0002113_abnormal_skeleton_development0.90317933
118MP0002751_abnormal_autonomic_nervous0.89358415
119MP0002114_abnormal_axial_skeleton0.88302903
120MP0008995_early_reproductive_senescence0.87152616
121MP0003279_aneurysm0.87110610
122* MP0002066_abnormal_motor_capabilities/c0.85791713
123MP0006054_spinal_hemorrhage0.84843498
124MP0005645_abnormal_hypothalamus_physiol0.84528511
125MP0000462_abnormal_digestive_system0.84502531
126MP0000026_abnormal_inner_ear0.84206480
127MP0004145_abnormal_muscle_electrophysio0.83268101
128MP0001963_abnormal_hearing_physiology0.83087363
129MP0003567_abnormal_fetal_cardiomyocyte0.82091688
130MP0005394_taste/olfaction_phenotype0.81972051
131MP0005499_abnormal_olfactory_system0.81972051
132MP0001177_atelectasis0.81851611
133MP0002152_abnormal_brain_morphology0.81621153
134MP0000678_abnormal_parathyroid_gland0.81551933
135MP0002092_abnormal_eye_morphology0.80348770
136MP0002882_abnormal_neuron_morphology0.77838349
137MP0004811_abnormal_neuron_physiology0.75168904
138MP0000681_abnormal_thyroid_gland0.74054508
139MP0000015_abnormal_ear_pigmentation0.71227347
140MP0009703_decreased_birth_body0.70924344
141MP0001943_abnormal_respiration0.70003654

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)5.79684060
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.79684060
3Abnormality of the 4th metacarpal (HP:0010012)4.44683888
4Hyperventilation (HP:0002883)4.10245723
5Shallow orbits (HP:0000586)3.76620418
6Drooling (HP:0002307)3.74511429
7Midline defect of the nose (HP:0004122)3.66286497
8Microglossia (HP:0000171)3.46614831
9Excessive salivation (HP:0003781)3.41372654
10Protrusio acetabuli (HP:0003179)3.38052101
11Hepatoblastoma (HP:0002884)3.31644026
12Cortical dysplasia (HP:0002539)3.28331446
13Gait imbalance (HP:0002141)3.13433337
14Cutaneous finger syndactyly (HP:0010554)3.02102221
15Intestinal atresia (HP:0011100)2.89403356
16Lissencephaly (HP:0001339)2.85776981
17Congenital primary aphakia (HP:0007707)2.83469467
18Split foot (HP:0001839)2.81729043
19Renal duplication (HP:0000075)2.80043234
20Medial flaring of the eyebrow (HP:0010747)2.76584729
21Pachygyria (HP:0001302)2.75183076
22Nephrogenic diabetes insipidus (HP:0009806)2.71478103
23Neoplasm of the heart (HP:0100544)2.71434580
24Bladder diverticulum (HP:0000015)2.70697333
25Focal motor seizures (HP:0011153)2.67078990
26Vaginal atresia (HP:0000148)2.66448031
27Genital tract atresia (HP:0001827)2.65001758
28Premature rupture of membranes (HP:0001788)2.60763641
29Cutaneous syndactyly (HP:0012725)2.56057781
30Aortic aneurysm (HP:0004942)2.53820374
31Asymmetry of the thorax (HP:0001555)2.48189639
32Septo-optic dysplasia (HP:0100842)2.45423207
33Nephronophthisis (HP:0000090)2.42612721
34Abnormality of the labia minora (HP:0012880)2.42199360
35Coronal craniosynostosis (HP:0004440)2.37717713
36Absent speech (HP:0001344)2.37662763
37Wide anterior fontanel (HP:0000260)2.37420447
38Polyphagia (HP:0002591)2.36002316
39Hypoplasia of the brainstem (HP:0002365)2.35578324
40Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35578324
41Aortic dissection (HP:0002647)2.34884274
42True hermaphroditism (HP:0010459)2.34356035
43Wide cranial sutures (HP:0010537)2.33551587
44Broad ribs (HP:0000885)2.31247121
45Optic nerve hypoplasia (HP:0000609)2.31055404
46Epileptic encephalopathy (HP:0200134)2.29911699
47Vascular tortuosity (HP:0004948)2.29201800
48Buphthalmos (HP:0000557)2.27946478
49Large earlobe (HP:0009748)2.27728247
50Lymphangioma (HP:0100764)2.27405411
51Specific learning disability (HP:0001328)2.27342503
52Abnormality of dentin (HP:0010299)2.27101388
53Flat cornea (HP:0007720)2.26192566
54Anteriorly placed anus (HP:0001545)2.24087608
55Fibular hypoplasia (HP:0003038)2.23311418
56Gastrointestinal atresia (HP:0002589)2.23292761
57Focal seizures (HP:0007359)2.22721173
58Wrist flexion contracture (HP:0001239)2.20533851
59Renal hypoplasia (HP:0000089)2.19524675
60Type II lissencephaly (HP:0007260)2.18860305
61Postaxial hand polydactyly (HP:0001162)2.18315974
62Renovascular hypertension (HP:0100817)2.16672820
63Megalencephaly (HP:0001355)2.16553396
64Vitreoretinal degeneration (HP:0000655)2.16214222
65Abnormality of midbrain morphology (HP:0002418)2.14736862
66Molar tooth sign on MRI (HP:0002419)2.14736862
67Trigonocephaly (HP:0000243)2.13858934
68Broad metatarsal (HP:0001783)2.13340204
69Short tibia (HP:0005736)2.10669278
70Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10668812
71Hypoplasia of the maxilla (HP:0000327)2.10459214
72Overgrowth (HP:0001548)2.08362197
73Increased number of teeth (HP:0011069)2.07447604
74Poor coordination (HP:0002370)2.06705677
75Aplasia/Hypoplasia of the clavicles (HP:0006710)2.06369189
76Pulmonary artery stenosis (HP:0004415)2.06307727
77Narrow nasal bridge (HP:0000446)2.05596682
78Bowel diverticulosis (HP:0005222)2.05182263
79Morphological abnormality of the middle ear (HP:0008609)2.04795108
80Pancreatic fibrosis (HP:0100732)2.03722720
81Sacral dimple (HP:0000960)2.03344171
82Soft skin (HP:0000977)2.02087811
83Diastasis recti (HP:0001540)2.01640410
84Retinal dysplasia (HP:0007973)2.01633119
85Abnormality of salivation (HP:0100755)2.01086987
86Exotropia (HP:0000577)2.01063135
87High anterior hairline (HP:0009890)2.00830976
88Abnormality of the phalanges of the hallux (HP:0010057)2.00139052
89Short clavicles (HP:0000894)2.00126216
90Micropenis (HP:0000054)1.99527117
91Polymicrogyria (HP:0002126)1.98961783
92Deviation of the hallux (HP:0010051)1.96717167
93Alacrima (HP:0000522)1.96596278
94Mitral valve prolapse (HP:0001634)1.95889980
95Limb dystonia (HP:0002451)1.94764469
96Oligodontia (HP:0000677)1.94532308
97Abnormality of the pubic bones (HP:0003172)1.94020751
98Hypoplasia of the corpus callosum (HP:0002079)1.93788953
99Esophageal atresia (HP:0002032)1.93117925
100Pancreatic cysts (HP:0001737)1.92704430
101Protruding tongue (HP:0010808)1.92520566
102Chorioretinal atrophy (HP:0000533)1.92464105
103Broad toe (HP:0001837)1.91417122
104Cerebellar dysplasia (HP:0007033)1.91280408
105Hemivertebrae (HP:0002937)1.91181443
106Broad foot (HP:0001769)1.91055690
107Agitation (HP:0000713)1.91044262
108Abnormality of the renal medulla (HP:0100957)1.90876375
109Hallux valgus (HP:0001822)1.90016076
110Medulloblastoma (HP:0002885)1.89174905
111Aplasia/Hypoplasia of the tibia (HP:0005772)1.88207643
112Urinary urgency (HP:0000012)1.88034305
113Abnormality of the aortic arch (HP:0012303)1.87743599
114Inability to walk (HP:0002540)1.87380879
115Abnormality of the nasolacrimal system (HP:0000614)1.87192956
116Abnormality of the corticospinal tract (HP:0002492)1.86352581
117Tracheomalacia (HP:0002779)1.86269451
118Ankle contracture (HP:0006466)1.86238727
119Genetic anticipation (HP:0003743)1.85485276
120Cupped ear (HP:0000378)1.85245661
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84819162
122Neonatal short-limb short stature (HP:0008921)1.84760895
123Arterial tortuosity (HP:0005116)1.84219032
124Blue irides (HP:0000635)1.83359634
125Abnormality of abdominal situs (HP:0011620)1.83235698
126Abdominal situs inversus (HP:0003363)1.83235698
127Impaired vibration sensation in the lower limbs (HP:0002166)1.83225117
128Tubulointerstitial nephritis (HP:0001970)1.83164079
129Myokymia (HP:0002411)1.82960825
130Joint laxity (HP:0001388)1.81787206
131Renal dysplasia (HP:0000110)1.81729930
132Increased nuchal translucency (HP:0010880)1.81307922
133Preaxial foot polydactyly (HP:0001841)1.80645617
134Aplasia/Hypoplasia of the fibula (HP:0006492)1.79771582
135Decreased testicular size (HP:0008734)1.78754653
136Abnormality of the parietal bone (HP:0002696)1.78484645
137Intellectual disability, moderate (HP:0002342)1.78050897
138Narrow forehead (HP:0000341)1.77922176
139Progressive cerebellar ataxia (HP:0002073)1.77913002
140Decreased lacrimation (HP:0000633)1.77407302
141Anophthalmia (HP:0000528)1.76799609
142Dilatation of the ascending aorta (HP:0005111)1.76160699
143Limited hip movement (HP:0008800)1.75582790
144Postaxial foot polydactyly (HP:0001830)1.75393164
145Tented upper lip vermilion (HP:0010804)1.74855127
146Abnormality of the lower motor neuron (HP:0002366)1.74503766
147Patellar dislocation (HP:0002999)1.74043282
148Oligodactyly (hands) (HP:0001180)1.74038338
149Atonic seizures (HP:0010819)1.73657135
150Camptodactyly of toe (HP:0001836)1.73245505
151Aplasia/Hypoplasia of the sternum (HP:0006714)1.72933562
152Febrile seizures (HP:0002373)1.72554607
153Omphalocele (HP:0001539)1.72405876
154Abnormality of the hip-girdle musculature (HP:0001445)1.72393835
155Abnormality of the musculature of the pelvis (HP:0001469)1.72393835
156Down-sloping shoulders (HP:0200021)1.71849556
157Abnormality of the antihelix (HP:0009738)1.71495960
158Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.71481431
159Chronic hepatic failure (HP:0100626)1.71084225
160Hyperextensible skin (HP:0000974)1.70579559
161Abnormality of the radial head (HP:0003995)1.70140633
162Dislocated radial head (HP:0003083)1.69859057
163Hypsarrhythmia (HP:0002521)1.69312863
164Narrow palate (HP:0000189)1.65508508
165Facial hemangioma (HP:0000329)1.65328374
166Heterochromia iridis (HP:0001100)1.64511303
167Wormian bones (HP:0002645)1.63653316
168Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.62916685
169Follicular hyperkeratosis (HP:0007502)1.62048461
170Shawl scrotum (HP:0000049)1.58898038
171Abnormality of the humeroradial joint (HP:0100744)1.57373922
172Atresia of the external auditory canal (HP:0000413)1.56570899
173Dental malocclusion (HP:0000689)1.56281467
174Abnormality of the lacrimal duct (HP:0011481)1.56242133
175Short philtrum (HP:0000322)1.55730925
176Abnormality of the diencephalon (HP:0010662)1.55600359
177Downturned corners of mouth (HP:0002714)1.55476227
178Complete atrioventricular canal defect (HP:0001674)1.54329146
179Hypoplasia of the fovea (HP:0007750)1.54325344
180Aplasia/Hypoplasia of the fovea (HP:0008060)1.54325344
181Broad long bones (HP:0005622)1.54300992
182Broad-based gait (HP:0002136)1.54032764
183Disproportionate tall stature (HP:0001519)1.53799344
184Hydroureter (HP:0000072)1.53541372
185Elfin facies (HP:0004428)1.51527902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.88176660
2EPHA43.82845247
3MARK13.62424661
4EPHB23.61927886
5DDR22.95881304
6KSR12.71780992
7PRPF4B2.52446101
8PDGFRA2.40397662
9CASK2.32850983
10FGFR22.14265589
11CCNB12.11673690
12TRIM282.08165526
13BRD42.04507160
14WNK31.94213408
15MAP4K21.93776738
16LATS21.89194115
17ERBB31.79535753
18TNIK1.78171577
19NUAK11.76669424
20PAK61.71602265
21PLK21.70877499
22NTRK31.62202252
23MAPK131.60525248
24ERBB21.59776734
25DYRK21.55633587
26TAOK21.46386545
27AKT31.41175940
28PNCK1.39123224
29MET1.35318023
30MINK11.34785761
31ZAK1.30862500
32RIPK11.30757299
33SIK11.30590067
34NTRK21.27127096
35PINK11.26611256
36FRK1.19615563
37SIK21.19322263
38MAP3K41.19291569
39FGFR11.19113466
40DYRK1B1.17885484
41PAK31.12383382
42TRIB31.10627957
43SRPK11.06214770
44ROCK11.05734462
45MST1R1.04957491
46DYRK31.04612765
47MAP3K61.03875902
48MAP2K71.03068863
49EPHB10.98519324
50PIK3CA0.85367511
51CSNK1A1L0.85038408
52CDK80.84982360
53MKNK20.84575638
54BCR0.84542967
55ROCK20.84432565
56PLK30.83059444
57MAPK150.80318501
58RPS6KA20.76310093
59PIM20.75863048
60SGK20.75762323
61CHEK20.73544485
62MAP3K100.73512957
63BCKDK0.72140903
64CDK190.71727269
65RPS6KA40.71261322
66ILK0.69992446
67PRKD30.68801477
68CSNK1G10.67822776
69BMX0.67465475
70PDGFRB0.66539840
71CSNK1G20.66415839
72DMPK0.65593265
73PRKCZ0.65231639
74SGK2230.64637955
75SGK4940.64637955
76OBSCN0.63703103
77DYRK1A0.62887442
78KSR20.62052303
79TTN0.61647918
80TYRO30.58964920
81CSNK1G30.57502519
82MAPK90.57407494
83PRKCG0.56757307
84CDC42BPA0.55533357
85PTK2B0.55475630
86PRKAA10.55380315
87CAMK40.54849224
88INSRR0.52908219
89CDK50.52834773
90CDK30.52639458
91PRKCE0.52307330
92CAMK1G0.51330881
93ADRBK10.51316686
94NTRK10.50746729
95VRK10.50732082
96FER0.50240583
97SIK30.49071002
98CDK11A0.48926274
99BMPR1B0.48742288
100STK380.46485442
101ICK0.46428957
102CSNK1D0.46088409
103ERBB40.45847109
104MKNK10.45570997
105CAMKK20.45009090
106LIMK10.44912567
107FGFR30.44186157
108SGK30.44072308
109CDK180.43168456
110MAPK100.42629384
111PHKG20.42363514
112PHKG10.42363514
113CAMK1D0.42269104
114PKN10.42190504
115CAMK2A0.42064000
116MAPK80.41244492
117PTK20.40988803
118DAPK20.40880023
119ADRBK20.40049683
120MTOR0.39971745
121GRK10.39410810
122RPS6KA50.39235878
123STK30.39158464
124PRKACB0.39077285
125PRKACA0.38679512
126PAK20.38616123
127YES10.38381284
128UHMK10.38352833
129CDK140.38185907
130MAP2K40.38049453
131CDK10.37861369
132GSK3B0.37720661
133STK38L0.37390442
134CAMK2B0.37044347
135CDK150.36656485
136RET0.36512807
137WEE10.35635732
138PRKG10.34337030
139CSNK1A10.32437929
140CSNK1E0.30305594
141STK390.29800458
142RPS6KA30.26818389

Predicted pathways (KEGG)

RankGene SetZ-score
1* Axon guidance_Homo sapiens_hsa043603.07223911
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.82465587
3Basal cell carcinoma_Homo sapiens_hsa052172.74539357
4Nicotine addiction_Homo sapiens_hsa050332.57759514
5Hedgehog signaling pathway_Homo sapiens_hsa043402.17835247
6Hippo signaling pathway_Homo sapiens_hsa043901.98015359
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.95972162
8Steroid biosynthesis_Homo sapiens_hsa001001.91159931
9Circadian entrainment_Homo sapiens_hsa047131.85908656
10Melanogenesis_Homo sapiens_hsa049161.83809556
11Wnt signaling pathway_Homo sapiens_hsa043101.82404249
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73091642
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66785663
14TGF-beta signaling pathway_Homo sapiens_hsa043501.64731343
15Glutamatergic synapse_Homo sapiens_hsa047241.56160063
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56036475
17GABAergic synapse_Homo sapiens_hsa047271.55077984
18Long-term potentiation_Homo sapiens_hsa047201.54115437
19Colorectal cancer_Homo sapiens_hsa052101.53892335
20MicroRNAs in cancer_Homo sapiens_hsa052061.50130741
21Endometrial cancer_Homo sapiens_hsa052131.50083969
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46106268
23Renin secretion_Homo sapiens_hsa049241.44638307
24Gap junction_Homo sapiens_hsa045401.44171333
25Phototransduction_Homo sapiens_hsa047441.42866353
26Morphine addiction_Homo sapiens_hsa050321.42505798
27Butanoate metabolism_Homo sapiens_hsa006501.41102316
28ECM-receptor interaction_Homo sapiens_hsa045121.40804149
29Long-term depression_Homo sapiens_hsa047301.40590235
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39044667
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36043673
32Glioma_Homo sapiens_hsa052141.36003280
33Dopaminergic synapse_Homo sapiens_hsa047281.33474345
34Olfactory transduction_Homo sapiens_hsa047401.33074615
35Focal adhesion_Homo sapiens_hsa045101.32589359
36Dilated cardiomyopathy_Homo sapiens_hsa054141.29141516
37Melanoma_Homo sapiens_hsa052181.27899133
38Adherens junction_Homo sapiens_hsa045201.27608102
39Cholinergic synapse_Homo sapiens_hsa047251.26836563
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23349245
41Amphetamine addiction_Homo sapiens_hsa050311.22286782
42Proteoglycans in cancer_Homo sapiens_hsa052051.22191195
43Cardiac muscle contraction_Homo sapiens_hsa042601.20822064
44Oxytocin signaling pathway_Homo sapiens_hsa049211.19419751
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19384990
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18319913
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16904465
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16072586
49Protein digestion and absorption_Homo sapiens_hsa049741.15629850
50Salivary secretion_Homo sapiens_hsa049701.15556372
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14795482
52Propanoate metabolism_Homo sapiens_hsa006401.11599248
53Renal cell carcinoma_Homo sapiens_hsa052111.09348990
54ErbB signaling pathway_Homo sapiens_hsa040121.09234433
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07877813
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05572520
57Serotonergic synapse_Homo sapiens_hsa047261.04188467
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01032933
59Prostate cancer_Homo sapiens_hsa052150.97827692
60cAMP signaling pathway_Homo sapiens_hsa040240.97051734
61Notch signaling pathway_Homo sapiens_hsa043300.96387343
62Taste transduction_Homo sapiens_hsa047420.96215094
63Rap1 signaling pathway_Homo sapiens_hsa040150.96069532
64Calcium signaling pathway_Homo sapiens_hsa040200.94402784
65Fanconi anemia pathway_Homo sapiens_hsa034600.94389457
66Alcoholism_Homo sapiens_hsa050340.94333570
67Oocyte meiosis_Homo sapiens_hsa041140.94078372
68Circadian rhythm_Homo sapiens_hsa047100.93792656
69GnRH signaling pathway_Homo sapiens_hsa049120.92657059
70Protein export_Homo sapiens_hsa030600.91642674
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91623832
72Pathways in cancer_Homo sapiens_hsa052000.90474003
73Pancreatic cancer_Homo sapiens_hsa052120.89623515
74Cell cycle_Homo sapiens_hsa041100.89339862
75Synaptic vesicle cycle_Homo sapiens_hsa047210.89213932
76Estrogen signaling pathway_Homo sapiens_hsa049150.88707768
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88485835
78Cocaine addiction_Homo sapiens_hsa050300.88188611
79Insulin secretion_Homo sapiens_hsa049110.87243475
80mRNA surveillance pathway_Homo sapiens_hsa030150.86499532
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85198193
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84587860
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.83616030
84Type II diabetes mellitus_Homo sapiens_hsa049300.83136607
85MAPK signaling pathway_Homo sapiens_hsa040100.83034285
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82967935
87Ras signaling pathway_Homo sapiens_hsa040140.82667561
88Chronic myeloid leukemia_Homo sapiens_hsa052200.82400363
89Gastric acid secretion_Homo sapiens_hsa049710.82032823
90mTOR signaling pathway_Homo sapiens_hsa041500.81019381
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80392421
92N-Glycan biosynthesis_Homo sapiens_hsa005100.76560963
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75672297
94Choline metabolism in cancer_Homo sapiens_hsa052310.75529644
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74393441
96Non-small cell lung cancer_Homo sapiens_hsa052230.74298492
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.69826417
98Basal transcription factors_Homo sapiens_hsa030220.69735363
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68922289
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68901275
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68633529
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68194826
103Bladder cancer_Homo sapiens_hsa052190.68063506
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67972357
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.67520505
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67402950
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65579922
108Tight junction_Homo sapiens_hsa045300.65576984
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65293071
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64383031
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.63909089
112HTLV-I infection_Homo sapiens_hsa051660.63704156
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63019978
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61890086
115Lysine degradation_Homo sapiens_hsa003100.61779918
116Amoebiasis_Homo sapiens_hsa051460.60088244
117Systemic lupus erythematosus_Homo sapiens_hsa053220.60071928
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59039344
119Parkinsons disease_Homo sapiens_hsa050120.58850679
120Ether lipid metabolism_Homo sapiens_hsa005650.58454712
121AMPK signaling pathway_Homo sapiens_hsa041520.58393034
122Small cell lung cancer_Homo sapiens_hsa052220.57937722
123Nitrogen metabolism_Homo sapiens_hsa009100.57584810
124FoxO signaling pathway_Homo sapiens_hsa040680.57346571
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48543578
126Huntingtons disease_Homo sapiens_hsa050160.47283016
127Regulation of autophagy_Homo sapiens_hsa041400.46316521
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46285292
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45376613
130Oxidative phosphorylation_Homo sapiens_hsa001900.45067104
131Collecting duct acid secretion_Homo sapiens_hsa049660.44848584
132Linoleic acid metabolism_Homo sapiens_hsa005910.43865108
133Ovarian steroidogenesis_Homo sapiens_hsa049130.40976054
134Fatty acid metabolism_Homo sapiens_hsa012120.39019636
135beta-Alanine metabolism_Homo sapiens_hsa004100.37993566
136ABC transporters_Homo sapiens_hsa020100.37637750
137RNA degradation_Homo sapiens_hsa030180.35128719

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