EPHA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.61553161
2vocalization behavior (GO:0071625)5.44377293
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42507718
4ionotropic glutamate receptor signaling pathway (GO:0035235)5.34275342
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.24100616
6neuron cell-cell adhesion (GO:0007158)5.19709244
7protein localization to synapse (GO:0035418)5.03391275
8regulation of glutamate receptor signaling pathway (GO:1900449)5.03107404
9glutamate receptor signaling pathway (GO:0007215)5.01706780
10locomotory exploration behavior (GO:0035641)4.92192177
11synaptic transmission, glutamatergic (GO:0035249)4.67650180
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.64064380
13synaptic vesicle exocytosis (GO:0016079)4.60540594
14presynaptic membrane assembly (GO:0097105)4.51184475
15neuron-neuron synaptic transmission (GO:0007270)4.45677769
16glutamate secretion (GO:0014047)4.42221039
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.41332858
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39609381
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.36763643
20exploration behavior (GO:0035640)4.35775738
21* neuron recognition (GO:0008038)4.32688710
22pyrimidine nucleobase catabolic process (GO:0006208)4.32021042
23limb bud formation (GO:0060174)4.30591505
24positive regulation of synapse maturation (GO:0090129)4.29983503
25regulation of neuronal synaptic plasticity (GO:0048168)4.21506456
26gamma-aminobutyric acid signaling pathway (GO:0007214)4.20629386
27regulation of synaptic vesicle exocytosis (GO:2000300)4.17874408
28neurotransmitter-gated ion channel clustering (GO:0072578)4.16645895
29presynaptic membrane organization (GO:0097090)4.12560412
30regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08983928
31synaptic vesicle maturation (GO:0016188)4.07818476
32dendritic spine morphogenesis (GO:0060997)4.01457421
33neuronal action potential propagation (GO:0019227)3.97751990
34postsynaptic membrane organization (GO:0001941)3.96174048
35regulation of postsynaptic membrane potential (GO:0060078)3.88283697
36behavioral fear response (GO:0001662)3.87934346
37behavioral defense response (GO:0002209)3.87934346
38long-term memory (GO:0007616)3.87007421
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.85065189
40* regulation of dendritic spine morphogenesis (GO:0061001)3.82406684
41long-term synaptic potentiation (GO:0060291)3.79877574
42regulation of synaptic vesicle transport (GO:1902803)3.76816036
43regulation of synaptic plasticity (GO:0048167)3.76094619
44* axonal fasciculation (GO:0007413)3.74672623
45transmission of nerve impulse (GO:0019226)3.68541233
46positive regulation of dendritic spine morphogenesis (GO:0061003)3.65956930
47positive regulation of membrane potential (GO:0045838)3.65626696
48positive regulation of neurotransmitter secretion (GO:0001956)3.63299129
49layer formation in cerebral cortex (GO:0021819)3.63274760
50dendritic spine organization (GO:0097061)3.62214228
51fear response (GO:0042596)3.57426633
52response to histamine (GO:0034776)3.55482787
53regulation of synapse structural plasticity (GO:0051823)3.55456407
54synaptic vesicle endocytosis (GO:0048488)3.55036050
55negative regulation of synaptic transmission, GABAergic (GO:0032229)3.53242758
56regulation of synapse maturation (GO:0090128)3.51050583
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.45393991
58innervation (GO:0060384)3.43518590
59somite development (GO:0061053)3.42407405
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40295973
61positive regulation of dendritic spine development (GO:0060999)3.38427091
62nucleobase catabolic process (GO:0046113)3.37710694
63* regulation of dendritic spine development (GO:0060998)3.36297122
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36028396
65regulation of glutamate secretion (GO:0014048)3.34918730
66neurotransmitter secretion (GO:0007269)3.29824536
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29460592
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.29221342
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27414324
70cochlea development (GO:0090102)3.27285622
71learning (GO:0007612)3.21429616
72cerebral cortex radially oriented cell migration (GO:0021799)3.20606153
73regulation of vesicle fusion (GO:0031338)3.19075409
74long term synaptic depression (GO:0060292)3.18026702
75membrane depolarization (GO:0051899)3.14956422
76olfactory bulb development (GO:0021772)3.13979119
77retinal ganglion cell axon guidance (GO:0031290)3.13241118
78startle response (GO:0001964)3.12045904
79cerebellar granule cell differentiation (GO:0021707)3.11172546
80cellular potassium ion homeostasis (GO:0030007)3.10867325
81behavioral response to cocaine (GO:0048148)3.10798689
82positive regulation of neurotransmitter transport (GO:0051590)3.08990788
83* central nervous system projection neuron axonogenesis (GO:0021952)3.08836251
84regulation of neurotransmitter secretion (GO:0046928)3.08132686
85spinal cord development (GO:0021510)3.05573333
86negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.03463882
87positive regulation of synapse assembly (GO:0051965)3.02854660
88dendrite morphogenesis (GO:0048813)2.98743373
89gamma-aminobutyric acid transport (GO:0015812)2.95325229
90* central nervous system neuron axonogenesis (GO:0021955)2.94764393
91synapse assembly (GO:0007416)2.93525231
92regulation of synaptic transmission (GO:0050804)2.91953994
93* ephrin receptor signaling pathway (GO:0048013)2.88694519
94regulation of female receptivity (GO:0045924)2.88399692
95regulation of synapse organization (GO:0050807)2.86817383
96neuromuscular process controlling balance (GO:0050885)2.86106674
97positive regulation of synaptic transmission (GO:0050806)2.85010335
98synaptic transmission (GO:0007268)2.84261934
99regulation of respiratory system process (GO:0044065)2.84193420
100establishment of nucleus localization (GO:0040023)2.84192468
101synapse organization (GO:0050808)2.83588969
102regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.81629619
103neuronal ion channel clustering (GO:0045161)2.81555371
104chemosensory behavior (GO:0007635)2.81054828
105negative regulation of amino acid transport (GO:0051956)2.80132176
106auditory behavior (GO:0031223)2.79633471
107cerebellar Purkinje cell differentiation (GO:0021702)2.79495888
108cell migration in hindbrain (GO:0021535)2.79244618
109membrane depolarization during action potential (GO:0086010)2.78918119
110glial cell proliferation (GO:0014009)2.78454608
111sodium ion export (GO:0071436)2.78416905
112negative chemotaxis (GO:0050919)2.76415681
113appendage development (GO:0048736)2.75474426
114limb development (GO:0060173)2.75474426
115hippocampus development (GO:0021766)2.72108028
116forebrain neuron differentiation (GO:0021879)2.71756552
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.71202779
118lateral sprouting from an epithelium (GO:0060601)2.70667344
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69373028
120nonmotile primary cilium assembly (GO:0035058)2.68502406
121atrial cardiac muscle cell action potential (GO:0086014)2.65724304
122axon extension involved in axon guidance (GO:0048846)2.62555406
123neuron projection extension involved in neuron projection guidance (GO:1902284)2.62555406
124regulation of synapse assembly (GO:0051963)2.61019111
125mechanosensory behavior (GO:0007638)2.60271012
126cell proliferation in forebrain (GO:0021846)2.56954479
127regulation of axon guidance (GO:1902667)2.55251351
128neuronal stem cell maintenance (GO:0097150)2.55186514
129regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54342028
130cranial nerve structural organization (GO:0021604)2.52965815
131neuron fate determination (GO:0048664)2.52200291
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48495763
133cardiac ventricle formation (GO:0003211)2.48458158
134neural tube formation (GO:0001841)2.45996708
135paraxial mesoderm development (GO:0048339)2.45725101
136negative regulation of dendrite development (GO:2000171)2.45252822
137cell communication by electrical coupling (GO:0010644)2.44675551
138sympathetic nervous system development (GO:0048485)2.43499028
139negative regulation of axon guidance (GO:1902668)2.40928422
140cerebral cortex cell migration (GO:0021795)2.40155928
141short-term memory (GO:0007614)2.39426901
142negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39409732
143cerebral cortex development (GO:0021987)2.39291000
144regulation of timing of cell differentiation (GO:0048505)2.38571762
145dendrite development (GO:0016358)2.38131288
146intraciliary transport (GO:0042073)2.37450455

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.25948930
2GBX2_23144817_ChIP-Seq_PC3_Human4.21063166
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15830252
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07262440
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00181432
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67630685
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67630685
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66313441
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.64369871
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59891002
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58360170
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.52213236
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49719542
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41123477
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.34981222
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32346739
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.26052202
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22311586
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.21230925
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13673669
21DROSHA_22980978_ChIP-Seq_HELA_Human2.13057875
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10334654
23TAF15_26573619_Chip-Seq_HEK293_Human2.10187065
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07104578
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06842213
26* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05411768
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03974036
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86875562
29AR_21572438_ChIP-Seq_LNCaP_Human1.85248560
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82942437
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82779076
32* REST_18959480_ChIP-ChIP_MESCs_Mouse1.82198348
33* RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79608588
34SMAD4_21799915_ChIP-Seq_A2780_Human1.78406084
35FUS_26573619_Chip-Seq_HEK293_Human1.74143475
36* P300_19829295_ChIP-Seq_ESCs_Human1.70445701
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69210517
38* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69102153
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69092286
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.68758999
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68146509
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63086294
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60320552
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57918553
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.56610021
46* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52738859
47VDR_22108803_ChIP-Seq_LS180_Human1.52377495
48ZNF274_21170338_ChIP-Seq_K562_Hela1.51051035
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50059915
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48777291
51* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44040918
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.42989529
53* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41257918
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40193461
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36618213
56* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35749394
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34452624
58* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33690256
59* AR_25329375_ChIP-Seq_VCAP_Human1.32777949
60IGF1R_20145208_ChIP-Seq_DFB_Human1.31219451
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.30427076
62TP53_16413492_ChIP-PET_HCT116_Human1.30372280
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30202097
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28025509
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.27417903
66RNF2_27304074_Chip-Seq_NSC_Mouse1.27166173
67* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26758426
68STAT3_23295773_ChIP-Seq_U87_Human1.26588298
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24395127
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23418716
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22731253
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22589461
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22094149
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.21387675
75* TP53_18474530_ChIP-ChIP_U2OS_Human1.20428691
76* ISL1_27105846_Chip-Seq_CPCs_Mouse1.20405256
77* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18329639
78* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16821600
79* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16406833
80* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16003549
81* TCF4_23295773_ChIP-Seq_U87_Human1.15683123
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15152317
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15035940
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14624009
85* AR_19668381_ChIP-Seq_PC3_Human1.14117648
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.13602041
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11918043
88TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11363853
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11196802
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11196802
91* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10912837
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.09148490
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08721477
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08674484
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08327952
96CBP_20019798_ChIP-Seq_JUKART_Human1.08327952
97JUN_21703547_ChIP-Seq_K562_Human1.08002590
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07425381
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06523346
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05854116
101* AHR_22903824_ChIP-Seq_MCF-7_Human1.05681319
102* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05391032
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04432852
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04051580
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03914866
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03832692
107* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03004311
108* FLI1_27457419_Chip-Seq_LIVER_Mouse1.02723547
109ER_23166858_ChIP-Seq_MCF-7_Human1.02604249
110* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02307573
111SOX9_26525672_Chip-Seq_HEART_Mouse1.01644563
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00654833
113BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00461802
114* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00145062
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97747155
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96094936
117* EWS_26573619_Chip-Seq_HEK293_Human0.95840998
118* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93460636
119* BCAT_22108803_ChIP-Seq_LS180_Human0.93312186
120RXR_22108803_ChIP-Seq_LS180_Human0.92900713

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.71183079
2* MP0003880_abnormal_central_pattern5.08420357
3* MP0003635_abnormal_synaptic_transmissio4.03046289
4MP0004270_analgesia3.55566344
5MP0002063_abnormal_learning/memory/cond3.41615627
6MP0009745_abnormal_behavioral_response3.37687016
7MP0002064_seizures2.97040916
8MP0001968_abnormal_touch/_nociception2.93972350
9MP0002572_abnormal_emotion/affect_behav2.82996796
10MP0010030_abnormal_orbit_morphology2.53121154
11MP0009046_muscle_twitch2.49252583
12MP0002272_abnormal_nervous_system2.48228493
13MP0001486_abnormal_startle_reflex2.45623083
14MP0002736_abnormal_nociception_after2.39767492
15MP0002735_abnormal_chemical_nociception2.25345580
16* MP0000778_abnormal_nervous_system2.20551238
17MP0002734_abnormal_mechanical_nocicepti2.19555172
18MP0001440_abnormal_grooming_behavior2.19315824
19MP0005423_abnormal_somatic_nervous2.17846582
20MP0001501_abnormal_sleep_pattern2.15630768
21MP0000566_synostosis2.12540461
22MP0002822_catalepsy2.07661408
23MP0003787_abnormal_imprinting2.06546380
24MP0003136_yellow_coat_color1.97924628
25MP0001293_anophthalmia1.81530341
26MP0008789_abnormal_olfactory_epithelium1.80322103
27* MP0002067_abnormal_sensory_capabilities1.78584175
28* MP0002184_abnormal_innervation1.74551672
29MP0001188_hyperpigmentation1.73598713
30MP0009780_abnormal_chondrocyte_physiolo1.70608677
31MP0003329_amyloid_beta_deposits1.66695263
32MP0002233_abnormal_nose_morphology1.65676281
33MP0001529_abnormal_vocalization1.63652059
34MP0002733_abnormal_thermal_nociception1.63566607
35MP0001970_abnormal_pain_threshold1.58728101
36* MP0002557_abnormal_social/conspecific_i1.57457009
37MP0001299_abnormal_eye_distance/1.55821598
38MP0004811_abnormal_neuron_physiology1.55593385
39MP0004924_abnormal_behavior1.55265969
40MP0005386_behavior/neurological_phenoty1.55265969
41MP0005248_abnormal_Harderian_gland1.54150782
42MP0006276_abnormal_autonomic_nervous1.53338670
43MP0006292_abnormal_olfactory_placode1.53183393
44MP0003937_abnormal_limbs/digits/tail_de1.48696156
45MP0002938_white_spotting1.46355881
46* MP0000955_abnormal_spinal_cord1.44171855
47MP0005409_darkened_coat_color1.42056091
48MP0004885_abnormal_endolymph1.41706832
49MP0001984_abnormal_olfaction1.40928374
50* MP0002882_abnormal_neuron_morphology1.40777893
51MP0000049_abnormal_middle_ear1.40767854
52MP0004858_abnormal_nervous_system1.40701092
53MP0000579_abnormal_nail_morphology1.40184772
54MP0005646_abnormal_pituitary_gland1.38634922
55MP0003890_abnormal_embryonic-extraembry1.38229041
56MP0008569_lethality_at_weaning1.31833348
57MP0002751_abnormal_autonomic_nervous1.31134819
58MP0002837_dystrophic_cardiac_calcinosis1.30078163
59* MP0002066_abnormal_motor_capabilities/c1.29180162
60MP0001905_abnormal_dopamine_level1.28777772
61MP0003755_abnormal_palate_morphology1.26360666
62MP0003879_abnormal_hair_cell1.25404874
63MP0004133_heterotaxia1.23809204
64MP0002653_abnormal_ependyma_morphology1.19530062
65* MP0002152_abnormal_brain_morphology1.18972563
66MP0000428_abnormal_craniofacial_morphol1.18784172
67MP0000569_abnormal_digit_pigmentation1.18519190
68MP0000537_abnormal_urethra_morphology1.17047306
69MP0001346_abnormal_lacrimal_gland1.15022683
70MP0002697_abnormal_eye_size1.14971777
71MP0004145_abnormal_muscle_electrophysio1.13809645
72MP0003122_maternal_imprinting1.13212521
73MP0000647_abnormal_sebaceous_gland1.09097668
74MP0003385_abnormal_body_wall1.07930020
75MP0003633_abnormal_nervous_system1.06929133
76MP0002909_abnormal_adrenal_gland1.04971932
77MP0004742_abnormal_vestibular_system1.03279918
78MP0003878_abnormal_ear_physiology1.03002470
79MP0005377_hearing/vestibular/ear_phenot1.03002470
80MP0001502_abnormal_circadian_rhythm1.01633849
81MP0001286_abnormal_eye_development0.99147451
82MP0000751_myopathy0.99105148
83MP0003938_abnormal_ear_development0.98809757
84MP0003631_nervous_system_phenotype0.98293958
85MP0005253_abnormal_eye_physiology0.97140104
86MP0005499_abnormal_olfactory_system0.95627384
87MP0005394_taste/olfaction_phenotype0.95627384
88MP0009053_abnormal_anal_canal0.95547395
89MP0000631_abnormal_neuroendocrine_gland0.94362209
90MP0005391_vision/eye_phenotype0.94346420
91MP0001485_abnormal_pinna_reflex0.94295620
92MP0004484_altered_response_of0.93813881
93MP0005645_abnormal_hypothalamus_physiol0.93629858
94MP0005171_absent_coat_pigmentation0.93209668
95MP0000534_abnormal_ureter_morphology0.92986232
96MP0001177_atelectasis0.92970190
97MP0003942_abnormal_urinary_system0.92763645
98MP0003935_abnormal_craniofacial_develop0.91960561
99MP0000383_abnormal_hair_follicle0.91545377
100MP0002638_abnormal_pupillary_reflex0.91315945
101MP0001963_abnormal_hearing_physiology0.90930318
102MP0004085_abnormal_heartbeat0.90344396
103MP0004215_abnormal_myocardial_fiber0.90061493
104MP0002234_abnormal_pharynx_morphology0.89708541
105MP0005551_abnormal_eye_electrophysiolog0.88490961
106MP0002092_abnormal_eye_morphology0.87993239
107MP0002249_abnormal_larynx_morphology0.87972331
108* MP0003861_abnormal_nervous_system0.85350257
109* MP0002752_abnormal_somatic_nervous0.85108782
110MP0002081_perinatal_lethality0.83370041
111MP0004142_abnormal_muscle_tone0.82695629
112MP0002116_abnormal_craniofacial_bone0.80765546
113MP0010386_abnormal_urinary_bladder0.80546036
114MP0004147_increased_porphyrin_level0.80429920
115MP0010234_abnormal_vibrissa_follicle0.80075483
116MP0002069_abnormal_eating/drinking_beha0.78851902
117MP0003121_genomic_imprinting0.77853311
118MP0000026_abnormal_inner_ear0.77426951
119MP0003632_abnormal_nervous_system0.77405435
120MP0002229_neurodegeneration0.77255523
121MP0003123_paternal_imprinting0.77051879
122MP0003137_abnormal_impulse_conducting0.75348829
123MP0004233_abnormal_muscle_weight0.74798583
124MP0005623_abnormal_meninges_morphology0.74480914
125MP0005187_abnormal_penis_morphology0.72773890
126MP0008874_decreased_physiological_sensi0.72021992
127MP0003634_abnormal_glial_cell0.69709185
128MP0000920_abnormal_myelination0.65956049
129MP0001943_abnormal_respiration0.60645567
130MP0003119_abnormal_digestive_system0.60069313
131MP0002876_abnormal_thyroid_physiology0.58645552
132MP0002102_abnormal_ear_morphology0.57256677
133MP0004510_myositis0.56655921
134MP0001664_abnormal_digestion0.54824116
135MP0009379_abnormal_foot_pigmentation0.53704932
136MP0008872_abnormal_physiological_respon0.52925173
137MP0003283_abnormal_digestive_organ0.52924766
138MP0008877_abnormal_DNA_methylation0.52241975
139MP0010769_abnormal_survival0.51336709
140MP0006072_abnormal_retinal_apoptosis0.51316006

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.25965397
2Focal seizures (HP:0007359)5.48283104
3Myokymia (HP:0002411)5.44046889
4Epileptic encephalopathy (HP:0200134)5.16301725
5Atonic seizures (HP:0010819)4.87765843
6Hyperventilation (HP:0002883)4.80031384
7Febrile seizures (HP:0002373)4.42822639
8Absence seizures (HP:0002121)4.21612448
9Visual hallucinations (HP:0002367)4.18844526
10Broad-based gait (HP:0002136)3.96828385
11Dialeptic seizures (HP:0011146)3.94136343
12Progressive cerebellar ataxia (HP:0002073)3.83062522
13Generalized tonic-clonic seizures (HP:0002069)3.55110796
14Amblyopia (HP:0000646)3.49490759
15Cerebral inclusion bodies (HP:0100314)3.23374745
16Excessive salivation (HP:0003781)3.19231418
17Drooling (HP:0002307)3.19231418
18Septo-optic dysplasia (HP:0100842)3.10806118
19Gaze-evoked nystagmus (HP:0000640)3.10645622
20Absent speech (HP:0001344)3.04736207
21Poor eye contact (HP:0000817)2.95692843
22Dysmetria (HP:0001310)2.88356747
23Dysdiadochokinesis (HP:0002075)2.83721489
24Neurofibrillary tangles (HP:0002185)2.83540536
25Supranuclear gaze palsy (HP:0000605)2.82235020
26Impaired vibration sensation in the lower limbs (HP:0002166)2.81655820
27Epileptiform EEG discharges (HP:0011182)2.70499146
28Optic nerve hypoplasia (HP:0000609)2.63901931
29Action tremor (HP:0002345)2.62550121
30Truncal ataxia (HP:0002078)2.59615423
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.57847291
32Short 4th metacarpal (HP:0010044)2.57847291
33Hemiparesis (HP:0001269)2.54768016
34Impaired social interactions (HP:0000735)2.51384519
35Abnormal social behavior (HP:0012433)2.51384519
36Genetic anticipation (HP:0003743)2.46682080
37Cutaneous syndactyly (HP:0012725)2.45330713
38Thickened helices (HP:0000391)2.41556897
39Preaxial foot polydactyly (HP:0001841)2.40555763
40Urinary bladder sphincter dysfunction (HP:0002839)2.39750168
41Anophthalmia (HP:0000528)2.37771908
42Scanning speech (HP:0002168)2.36908627
43EEG with generalized epileptiform discharges (HP:0011198)2.36814029
44Protruding tongue (HP:0010808)2.34456352
45Anxiety (HP:0000739)2.33960800
46Bifid tongue (HP:0010297)2.32798654
47Stereotypic behavior (HP:0000733)2.32376635
48Renal hypoplasia (HP:0000089)2.30752638
49Depression (HP:0000716)2.27640351
50Genital tract atresia (HP:0001827)2.26898400
51Volvulus (HP:0002580)2.26701889
52Insidious onset (HP:0003587)2.25305687
53Termporal pattern (HP:0011008)2.25305687
54Intestinal atresia (HP:0011100)2.25099673
55Vaginal atresia (HP:0000148)2.23919186
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22525124
57Abnormality of salivation (HP:0100755)2.20948065
58Abnormality of binocular vision (HP:0011514)2.20602786
59Diplopia (HP:0000651)2.20602786
60Abnormality of the lower motor neuron (HP:0002366)2.20391320
61Oligodactyly (hands) (HP:0001180)2.20032403
62Vitreoretinal degeneration (HP:0000655)2.18033609
63Abnormality of the 4th metacarpal (HP:0010012)2.17885066
64Impaired smooth pursuit (HP:0007772)2.17458964
65High anterior hairline (HP:0009890)2.14590919
66Abnormality of the corticospinal tract (HP:0002492)2.14440075
67Fetal akinesia sequence (HP:0001989)2.12069569
68Hydroureter (HP:0000072)2.11227382
69Hypsarrhythmia (HP:0002521)2.11159964
70Medial flaring of the eyebrow (HP:0010747)2.10738602
71Generalized myoclonic seizures (HP:0002123)2.10539781
72Congenital primary aphakia (HP:0007707)2.08585219
73Inability to walk (HP:0002540)2.06857600
74Colon cancer (HP:0003003)2.06670551
75Abnormal eating behavior (HP:0100738)2.05597747
76Thyroid-stimulating hormone excess (HP:0002925)2.05152168
77Oligodactyly (HP:0012165)2.03730642
78Widely spaced teeth (HP:0000687)2.03523348
79True hermaphroditism (HP:0010459)2.02409991
80Split foot (HP:0001839)2.00222291
81Gastroesophageal reflux (HP:0002020)1.99476814
82Postaxial hand polydactyly (HP:0001162)1.99463834
83Gastrointestinal atresia (HP:0002589)1.98983967
84Pancreatic fibrosis (HP:0100732)1.98743141
85Absent septum pellucidum (HP:0001331)1.98659537
86Degeneration of the lateral corticospinal tracts (HP:0002314)1.98297720
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98297720
88Spastic gait (HP:0002064)1.96212964
89Abnormality of the antihelix (HP:0009738)1.95557554
90Megalencephaly (HP:0001355)1.93890039
91Nephrogenic diabetes insipidus (HP:0009806)1.93793439
92Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92884611
93Delusions (HP:0000746)1.92452410
94Esophageal atresia (HP:0002032)1.92216277
95Abnormality of the aortic arch (HP:0012303)1.91762477
96Urinary urgency (HP:0000012)1.91757208
97Mutism (HP:0002300)1.90799990
98Postural instability (HP:0002172)1.88000296
99Ankle clonus (HP:0011448)1.87023439
100Abnormality of midbrain morphology (HP:0002418)1.85883701
101Molar tooth sign on MRI (HP:0002419)1.85883701
102Incomplete penetrance (HP:0003829)1.85775228
103Obstructive sleep apnea (HP:0002870)1.85666612
104Coronal craniosynostosis (HP:0004440)1.85314667
105Poor coordination (HP:0002370)1.84909229
106Intention tremor (HP:0002080)1.83406443
107Abnormality of ocular smooth pursuit (HP:0000617)1.82866673
108Progressive inability to walk (HP:0002505)1.82820294
109Postaxial foot polydactyly (HP:0001830)1.81955588
110Abnormality of the septum pellucidum (HP:0007375)1.81864701
111Blue irides (HP:0000635)1.81752664
112Aqueductal stenosis (HP:0002410)1.81611761
113Labial hypoplasia (HP:0000066)1.81156059
114Lower limb muscle weakness (HP:0007340)1.80168055
115Gait imbalance (HP:0002141)1.79910329
116Nephronophthisis (HP:0000090)1.78731192
117Impaired vibratory sensation (HP:0002495)1.77838375
118Pancreatic cysts (HP:0001737)1.77798216
119Choroideremia (HP:0001139)1.77524312
120Lower limb asymmetry (HP:0100559)1.77390624
121Bradykinesia (HP:0002067)1.77360400
122Preaxial hand polydactyly (HP:0001177)1.75778308
123Limb dystonia (HP:0002451)1.74915670
124Broad thumb (HP:0011304)1.74804257
125Cutaneous finger syndactyly (HP:0010554)1.74792645
126Tented upper lip vermilion (HP:0010804)1.74780976
127Renal dysplasia (HP:0000110)1.74604135
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.74274918
129Autism (HP:0000717)1.73559105
130Amyotrophic lateral sclerosis (HP:0007354)1.73486785
131Exotropia (HP:0000577)1.73117186
132Partial duplication of thumb phalanx (HP:0009944)1.73023058
133Midline defect of the nose (HP:0004122)1.73015564
134Broad foot (HP:0001769)1.72338271
135Micropenis (HP:0000054)1.72290220
136Deeply set eye (HP:0000490)1.71619516
137Hemivertebrae (HP:0002937)1.70373262
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.70129686
139Inappropriate behavior (HP:0000719)1.69825139
140Aplasia involving bones of the extremities (HP:0009825)1.68567175
141Aplasia involving bones of the upper limbs (HP:0009823)1.68567175
142Aplasia of the phalanges of the hand (HP:0009802)1.68567175
143Fair hair (HP:0002286)1.67147961
144Trigonocephaly (HP:0000243)1.66664520
145Hepatoblastoma (HP:0002884)1.66145970
146Specific learning disability (HP:0001328)1.65976370
147Abnormality of the labia minora (HP:0012880)1.64947894
148Maternal diabetes (HP:0009800)1.64070104
149Status epilepticus (HP:0002133)1.63868748
150Absent/shortened dynein arms (HP:0200106)1.63499527
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.63499527
152Hypoplastic female external genitalia (HP:0012815)1.62905306
153Hypoplastic labia majora (HP:0000059)1.62895530
154Narrow forehead (HP:0000341)1.61718163
155Heterochromia iridis (HP:0001100)1.61462621
156Cerebellar dysplasia (HP:0007033)1.60833599
157Shawl scrotum (HP:0000049)1.60448421
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.58872218
159Palpebral edema (HP:0100540)1.58787043
160Gait ataxia (HP:0002066)1.58610428
161Abnormality of the renal medulla (HP:0100957)1.58579009
162Shoulder girdle muscle weakness (HP:0003547)1.58281696
163Rib fusion (HP:0000902)1.57996478
164Lower limb amyotrophy (HP:0007210)1.56201403
165Retinal dysplasia (HP:0007973)1.56177435
166Omphalocele (HP:0001539)1.55343201
167Broad finger (HP:0001500)1.55050144
168Intellectual disability, moderate (HP:0002342)1.54742896
169Supernumerary spleens (HP:0009799)1.53958584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.10244357
2* EPHA43.62365105
3CASK3.24945047
4RIPK43.04830492
5MAP3K92.87307150
6MAP3K42.87089813
7MARK12.61543465
8MAP2K72.50872931
9DAPK22.30781361
10PLK22.20581668
11MINK12.18234319
12KSR12.11427253
13PRPF4B2.06625368
14PAK61.93072664
15KSR21.89851513
16TRIM281.87582056
17PNCK1.85564627
18DAPK11.81908451
19TNIK1.81468068
20MAP3K121.76360674
21MAP2K41.67745332
22BMPR21.64867711
23NTRK21.61810750
24SIK21.54323747
25MKNK21.52852637
26CDK51.41454362
27MKNK11.38525295
28MAP4K21.37719276
29ARAF1.36881876
30CAMK2B1.36066236
31NTRK11.35876041
32CDK191.34766739
33CAMK2A1.33746427
34GRK51.31206429
35PTK2B1.29619062
36FES1.29045089
37FGR1.27994888
38DYRK21.27451452
39MAPK131.27414856
40BRD41.24202704
41PRKD31.22541187
42PRKCG1.22003863
43ERBB31.20828786
44FRK1.18994918
45RAF11.18166423
46NME11.14385499
47MAP3K131.10608065
48SRPK11.08822412
49CAMK1G1.07944958
50CSNK1A1L1.03853412
51AKT30.99509928
52CSNK1G10.98860787
53TYRO30.98562196
54CAMKK10.97166095
55OXSR10.96512598
56STK380.96322978
57CSNK1G30.92491388
58BMPR1B0.91707086
59BCR0.90038672
60FER0.88896184
61CDK180.83965972
62PAK30.83016993
63LATS20.82878765
64CDK150.80633110
65SGK4940.79350474
66SGK2230.79350474
67CDK140.78861397
68SGK10.78123521
69PLK30.78067494
70DYRK1A0.77820294
71MAP3K100.77790502
72DYRK30.77231509
73CAMK2D0.76364883
74FGFR10.73977935
75UHMK10.73201315
76MAP3K60.71650576
77CAMK10.71645721
78PRKCE0.70626118
79SGK20.69911726
80CDK11A0.69677450
81PHKG20.67733331
82PHKG10.67733331
83CAMK1D0.67576842
84MAP3K20.67513109
85NUAK10.67159231
86PIK3CA0.66073269
87STK110.62401290
88GRK10.61359338
89CSNK1G20.60709747
90EPHA30.59661072
91MARK20.59379325
92ROCK20.58455860
93BRSK10.56992641
94PLK40.56937901
95BRAF0.56580440
96DMPK0.55984395
97TIE10.54321119
98ERBB20.53279018
99TGFBR10.51061277
100WEE10.50865955
101CCNB10.49712141
102STK38L0.49642985
103NEK60.48002104
104FGFR20.47777249
105CSNK1D0.47763902
106CAMK2G0.47636024
107PRKCZ0.47151221
108LATS10.46595631
109MAP2K10.44556650
110DDR20.44088862
111MAPK100.43737385
112CDK30.42671069
113GRK70.42215530
114RPS6KA30.41093348
115MAP3K70.40854680
116PINK10.40080286
117SIK30.39942629
118SGK30.39603196
119CAMKK20.38660748
120FYN0.37291818
121ADRBK20.37111863
122ROCK10.36585959
123PDPK10.36561197
124VRK10.36339254
125PRKDC0.36268962
126CSNK1A10.36005784
127OBSCN0.35990964
128RET0.35840990
129BRSK20.35782579
130STK390.35496593
131EPHB20.35148681
132PKN10.34780196
133CAMK40.34657273
134ADRBK10.34134026
135WNK30.34002980
136PRKACA0.33053543
137PDK10.32761299
138CSNK1E0.32748733
139PRKCH0.32243021

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26971072
2Long-term potentiation_Homo sapiens_hsa047203.12584236
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90656922
4Circadian entrainment_Homo sapiens_hsa047132.81341663
5Glutamatergic synapse_Homo sapiens_hsa047242.78644605
6Amphetamine addiction_Homo sapiens_hsa050312.74133623
7Synaptic vesicle cycle_Homo sapiens_hsa047212.61264480
8Morphine addiction_Homo sapiens_hsa050322.54956936
9GABAergic synapse_Homo sapiens_hsa047272.53385175
10Olfactory transduction_Homo sapiens_hsa047402.42012805
11Salivary secretion_Homo sapiens_hsa049702.26095477
12Dopaminergic synapse_Homo sapiens_hsa047282.22505785
13Taste transduction_Homo sapiens_hsa047422.04457549
14Long-term depression_Homo sapiens_hsa047301.96300246
15Renin secretion_Homo sapiens_hsa049241.92478919
16Serotonergic synapse_Homo sapiens_hsa047261.90037342
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81657508
18Calcium signaling pathway_Homo sapiens_hsa040201.81414237
19Cholinergic synapse_Homo sapiens_hsa047251.78730877
20Oxytocin signaling pathway_Homo sapiens_hsa049211.78377237
21Gastric acid secretion_Homo sapiens_hsa049711.77951432
22Insulin secretion_Homo sapiens_hsa049111.74014539
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73528277
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70503403
25* Axon guidance_Homo sapiens_hsa043601.57545116
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55002615
27GnRH signaling pathway_Homo sapiens_hsa049121.52204296
28Cocaine addiction_Homo sapiens_hsa050301.51565297
29Collecting duct acid secretion_Homo sapiens_hsa049661.50031092
30Gap junction_Homo sapiens_hsa045401.39466864
31Steroid biosynthesis_Homo sapiens_hsa001001.39449483
32cAMP signaling pathway_Homo sapiens_hsa040241.36213251
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29682139
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29491177
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28882684
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28132867
37Melanogenesis_Homo sapiens_hsa049161.25333495
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17355317
39Glioma_Homo sapiens_hsa052141.14582335
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13355128
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12368979
42Estrogen signaling pathway_Homo sapiens_hsa049151.12029267
43ErbB signaling pathway_Homo sapiens_hsa040121.10643367
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09453444
45Phototransduction_Homo sapiens_hsa047441.06596570
46Cardiac muscle contraction_Homo sapiens_hsa042601.06208948
47Vascular smooth muscle contraction_Homo sapiens_hsa042701.04445519
48Fanconi anemia pathway_Homo sapiens_hsa034601.00782402
49Oocyte meiosis_Homo sapiens_hsa041140.98143267
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97230209
51Adherens junction_Homo sapiens_hsa045200.93159955
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.93157351
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91885364
54Choline metabolism in cancer_Homo sapiens_hsa052310.91530669
55TGF-beta signaling pathway_Homo sapiens_hsa043500.88869029
56Type II diabetes mellitus_Homo sapiens_hsa049300.88290009
57Vibrio cholerae infection_Homo sapiens_hsa051100.88033387
58Dilated cardiomyopathy_Homo sapiens_hsa054140.86820146
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.84996677
60Pancreatic secretion_Homo sapiens_hsa049720.83614136
61Propanoate metabolism_Homo sapiens_hsa006400.83418391
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81785763
63Wnt signaling pathway_Homo sapiens_hsa043100.81577179
64Non-homologous end-joining_Homo sapiens_hsa034500.80663584
65VEGF signaling pathway_Homo sapiens_hsa043700.79685957
66Alzheimers disease_Homo sapiens_hsa050100.76930187
67MAPK signaling pathway_Homo sapiens_hsa040100.75024851
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74470858
69African trypanosomiasis_Homo sapiens_hsa051430.74146381
70Ras signaling pathway_Homo sapiens_hsa040140.72219858
71Rap1 signaling pathway_Homo sapiens_hsa040150.71458454
72Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71253986
73Dorso-ventral axis formation_Homo sapiens_hsa043200.68526157
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64452195
75Notch signaling pathway_Homo sapiens_hsa043300.63342518
76Basal transcription factors_Homo sapiens_hsa030220.63246004
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62591831
78Butanoate metabolism_Homo sapiens_hsa006500.61805471
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61627269
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61163949
81ECM-receptor interaction_Homo sapiens_hsa045120.60675215
82Thyroid hormone synthesis_Homo sapiens_hsa049180.59184052
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58746033
84Nitrogen metabolism_Homo sapiens_hsa009100.58214688
85Glucagon signaling pathway_Homo sapiens_hsa049220.54168787
86Alcoholism_Homo sapiens_hsa050340.53434018
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.52344615
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52037782
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50139759
90Lysine degradation_Homo sapiens_hsa003100.48129408
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48082374
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.47963115
93mRNA surveillance pathway_Homo sapiens_hsa030150.47954420
94Oxidative phosphorylation_Homo sapiens_hsa001900.47815084
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45610447
96Renal cell carcinoma_Homo sapiens_hsa052110.44787312
97Protein export_Homo sapiens_hsa030600.44242680
98Hedgehog signaling pathway_Homo sapiens_hsa043400.42744237
99RNA degradation_Homo sapiens_hsa030180.42471432
100Protein digestion and absorption_Homo sapiens_hsa049740.42420966
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41966623
102Circadian rhythm_Homo sapiens_hsa047100.41365368
103Inositol phosphate metabolism_Homo sapiens_hsa005620.40755182
104MicroRNAs in cancer_Homo sapiens_hsa052060.39969295
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39446998
106Ovarian steroidogenesis_Homo sapiens_hsa049130.39278797
107mTOR signaling pathway_Homo sapiens_hsa041500.38593606
108Colorectal cancer_Homo sapiens_hsa052100.37266768
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36954247
110Tight junction_Homo sapiens_hsa045300.35240084
111Non-small cell lung cancer_Homo sapiens_hsa052230.35109868
112Endometrial cancer_Homo sapiens_hsa052130.34510320
113Mineral absorption_Homo sapiens_hsa049780.32707351
114Prion diseases_Homo sapiens_hsa050200.31845878
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31610823
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30975749
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30907470
118Hippo signaling pathway_Homo sapiens_hsa043900.30692089
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27841340
120Endocytosis_Homo sapiens_hsa041440.27452556
121Melanoma_Homo sapiens_hsa052180.27189746
122Rheumatoid arthritis_Homo sapiens_hsa053230.26897159
123Huntingtons disease_Homo sapiens_hsa050160.25338676
124Basal cell carcinoma_Homo sapiens_hsa052170.24356447
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24201507

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