EPHA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)6.13395440
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.80392068
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.74992518
4vocalization behavior (GO:0071625)5.74084263
5glutamate receptor signaling pathway (GO:0007215)5.47842860
6locomotory exploration behavior (GO:0035641)5.46418124
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.40732124
8protein localization to synapse (GO:0035418)5.29446679
9regulation of glutamate receptor signaling pathway (GO:1900449)5.16535436
10synaptic transmission, glutamatergic (GO:0035249)5.01910014
11neuron cell-cell adhesion (GO:0007158)4.98162584
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.82052168
13synaptic vesicle exocytosis (GO:0016079)4.75691432
14neuron-neuron synaptic transmission (GO:0007270)4.73710533
15exploration behavior (GO:0035640)4.73509976
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.68607146
17glutamate secretion (GO:0014047)4.66421683
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62555736
19neuronal action potential propagation (GO:0019227)4.59274544
20regulation of neuronal synaptic plasticity (GO:0048168)4.55060406
21synaptic vesicle maturation (GO:0016188)4.51111336
22regulation of excitatory postsynaptic membrane potential (GO:0060079)4.45212852
23neurotransmitter-gated ion channel clustering (GO:0072578)4.41771518
24positive regulation of cGMP biosynthetic process (GO:0030828)4.30327499
25neuron recognition (GO:0008038)4.26936722
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.19218111
27regulation of synaptic vesicle exocytosis (GO:2000300)4.18950909
28regulation of postsynaptic membrane potential (GO:0060078)4.18688970
29behavioral fear response (GO:0001662)4.18026406
30behavioral defense response (GO:0002209)4.18026406
31long-term memory (GO:0007616)4.16046443
32positive regulation of synapse maturation (GO:0090129)4.08051786
33gamma-aminobutyric acid signaling pathway (GO:0007214)4.04646138
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.03268579
35regulation of cGMP biosynthetic process (GO:0030826)4.00636479
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.99859424
37regulation of synaptic plasticity (GO:0048167)3.97605518
38regulation of synaptic vesicle transport (GO:1902803)3.94566253
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.93630773
40positive regulation of membrane potential (GO:0045838)3.90554183
41regulation of synapse structural plasticity (GO:0051823)3.89816177
42long-term synaptic potentiation (GO:0060291)3.89510623
43dendritic spine morphogenesis (GO:0060997)3.86823865
44regulation of dendritic spine morphogenesis (GO:0061001)3.85059058
45axonal fasciculation (GO:0007413)3.83927713
46fear response (GO:0042596)3.83701251
47presynaptic membrane assembly (GO:0097105)3.81596754
48startle response (GO:0001964)3.80795731
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.76847147
50neurotransmitter secretion (GO:0007269)3.75658085
51response to histamine (GO:0034776)3.74799674
52innervation (GO:0060384)3.70609375
53positive regulation of cGMP metabolic process (GO:0030825)3.68453577
54transmission of nerve impulse (GO:0019226)3.62554534
55postsynaptic membrane organization (GO:0001941)3.59646155
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.57546336
57chemosensory behavior (GO:0007635)3.51993963
58proline transport (GO:0015824)3.51975004
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51895139
60cellular potassium ion homeostasis (GO:0030007)3.51559093
61presynaptic membrane organization (GO:0097090)3.48829546
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.48719343
63central nervous system projection neuron axonogenesis (GO:0021952)3.48540668
64membrane depolarization (GO:0051899)3.46307074
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44594526
66dendritic spine organization (GO:0097061)3.41572597
67learning (GO:0007612)3.41196967
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.38083868
69cochlea development (GO:0090102)3.36740483
70synaptic vesicle endocytosis (GO:0048488)3.34885576
71regulation of cGMP metabolic process (GO:0030823)3.34329443
72gamma-aminobutyric acid transport (GO:0015812)3.32294757
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31768864
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.31610233
75regulation of dendritic spine development (GO:0060998)3.30491922
76layer formation in cerebral cortex (GO:0021819)3.30485119
77membrane depolarization during action potential (GO:0086010)3.29240264
78response to nitrosative stress (GO:0051409)3.27626632
79positive regulation of dendritic spine development (GO:0060999)3.25033747
80long term synaptic depression (GO:0060292)3.23632605
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.22921813
82positive regulation of neurotransmitter secretion (GO:0001956)3.22598814
83microtubule severing (GO:0051013)3.20392047
84cardiac ventricle formation (GO:0003211)3.19243630
85calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.18047646
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17284314
87retinal ganglion cell axon guidance (GO:0031290)3.15912418
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.14483123
89neurotransmitter transport (GO:0006836)3.13997736
90regulation of synapse maturation (GO:0090128)3.13153468
91regulation of vesicle fusion (GO:0031338)3.12725387
92sodium ion export (GO:0071436)3.12183300
93serotonin metabolic process (GO:0042428)3.12183001
94cell communication by electrical coupling (GO:0010644)3.09553044
95regulation of female receptivity (GO:0045924)3.08363361
96pyrimidine nucleobase catabolic process (GO:0006208)3.08205286
97synaptic transmission (GO:0007268)3.07834545
98regulation of synaptic transmission (GO:0050804)3.07701649
99neuromuscular process controlling balance (GO:0050885)3.07621673
100central nervous system neuron axonogenesis (GO:0021955)3.06221628
101behavioral response to cocaine (GO:0048148)3.05568175
102cerebellar Purkinje cell differentiation (GO:0021702)3.03607206
103regulation of glutamate secretion (GO:0014048)3.02520030
104positive regulation of cardiac muscle cell differentiation (GO:2000727)3.01138365
105positive regulation of synaptic transmission (GO:0050806)3.00504465
106mitochondrial genome maintenance (GO:0000002)2.99842519
107regulation of sarcomere organization (GO:0060297)2.98345633
108inner ear receptor cell development (GO:0060119)2.97269595
109intraspecies interaction between organisms (GO:0051703)2.96904759
110social behavior (GO:0035176)2.96904759
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96638442
112protein polyglutamylation (GO:0018095)2.95597663
113neuromuscular process (GO:0050905)2.94828312
114activation of protein kinase A activity (GO:0034199)2.94753834
115regulation of neurotransmitter secretion (GO:0046928)2.94585625
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.94417201
117regulation of neurotransmitter levels (GO:0001505)2.93119479
118synapse assembly (GO:0007416)2.92277238
119cardiac chamber formation (GO:0003207)2.92186144
120learning or memory (GO:0007611)2.91621187
121urinary tract smooth muscle contraction (GO:0014848)2.86011966
122motile cilium assembly (GO:0044458)2.84818703
123righting reflex (GO:0060013)2.84410024
124regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83410326
125tachykinin receptor signaling pathway (GO:0007217)2.74645455
126behavioral response to ethanol (GO:0048149)2.70800759
127response to pheromone (GO:0019236)2.69449442
128negative regulation of glucose import (GO:0046325)2.67219356
129homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.66795194
130intraciliary transport (GO:0042073)2.64840047
131cerebral cortex radially oriented cell migration (GO:0021799)2.64615132
132regulation of cilium movement (GO:0003352)2.64532527
133cilium movement (GO:0003341)2.64276016
134dendrite morphogenesis (GO:0048813)2.60825693
135cranial nerve morphogenesis (GO:0021602)2.57084495
136nerve growth factor signaling pathway (GO:0038180)2.54979865
137cranial nerve structural organization (GO:0021604)2.53106239
138negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52579357
139cerebral cortex development (GO:0021987)2.52496696
140striatum development (GO:0021756)2.49202454
141negative regulation of neurotransmitter secretion (GO:0046929)2.47612029
142branching involved in prostate gland morphogenesis (GO:0060442)2.46354677
143cAMP catabolic process (GO:0006198)2.42920138
144sympathetic nervous system development (GO:0048485)2.42624726
145atrial cardiac muscle cell action potential (GO:0086014)2.38647063
146positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38563497
147cilium or flagellum-dependent cell motility (GO:0001539)2.37387565
148C4-dicarboxylate transport (GO:0015740)2.34124011
149nucleus localization (GO:0051647)2.32488316
150nucleobase catabolic process (GO:0046113)2.32170758
151adult walking behavior (GO:0007628)2.32033851
152ventricular system development (GO:0021591)2.31203853
153primary amino compound metabolic process (GO:1901160)2.31182917
154regulation of pigment cell differentiation (GO:0050932)2.30655863
155secondary heart field specification (GO:0003139)2.30382429
156heart field specification (GO:0003128)2.30382429
157limb bud formation (GO:0060174)2.29841235
158microtubule polymerization or depolymerization (GO:0031109)2.29271306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58881515
2* GBX2_23144817_ChIP-Seq_PC3_Human4.22466744
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18976061
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13537850
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06462787
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.01846944
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.70453557
8REST_21632747_ChIP-Seq_MESCs_Mouse2.62210759
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60237250
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60237250
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57813494
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56349939
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44631314
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.44111290
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.38896330
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38236535
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37774465
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.35972735
19DROSHA_22980978_ChIP-Seq_HELA_Human2.26081358
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21681251
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.12642226
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08448382
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07800587
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.05446118
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05007644
26TAF15_26573619_Chip-Seq_HEK293_Human1.94787550
27* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93438403
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91629301
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89048992
30* EWS_26573619_Chip-Seq_HEK293_Human1.88794654
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.88222421
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80455789
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79672750
34AR_21572438_ChIP-Seq_LNCaP_Human1.76978851
35IRF1_19129219_ChIP-ChIP_H3396_Human1.76624743
36P300_19829295_ChIP-Seq_ESCs_Human1.71642655
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66823824
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65829676
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63295940
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61557038
41ZNF274_21170338_ChIP-Seq_K562_Hela1.56540793
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56145058
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52627148
44CBP_20019798_ChIP-Seq_JUKART_Human1.52627148
45* SOX9_26525672_Chip-Seq_HEART_Mouse1.52502164
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.50754234
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50146810
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48361929
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46621239
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46250242
51AR_25329375_ChIP-Seq_VCAP_Human1.45024465
52* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41254219
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41116926
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39619354
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37377774
56* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36820691
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36696681
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.36348832
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35648862
60* STAT3_23295773_ChIP-Seq_U87_Human1.35429263
61* FUS_26573619_Chip-Seq_HEK293_Human1.34396499
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.33508056
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.31501972
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.29938342
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.29273418
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28334935
67TP53_16413492_ChIP-PET_HCT116_Human1.27764784
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.25886618
69TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.25540268
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25501447
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22578210
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22291578
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.22207832
74AR_19668381_ChIP-Seq_PC3_Human1.21528909
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.20926859
76* TCF4_23295773_ChIP-Seq_U87_Human1.19714622
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.19319007
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18363908
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.17090291
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.16560902
81* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16279039
82TP53_18474530_ChIP-ChIP_U2OS_Human1.15911253
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15907109
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15644241
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15590944
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.15063306
87* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13022090
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12751714
89* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12031078
90AHR_22903824_ChIP-Seq_MCF-7_Human1.11447291
91* IGF1R_20145208_ChIP-Seq_DFB_Human1.10730592
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08951438
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08445356
94JUN_21703547_ChIP-Seq_K562_Human1.08423443
95RNF2_27304074_Chip-Seq_NSC_Mouse1.08096835
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07195581
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06563159
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06006845
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05903963
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05449590
101* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04770654
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.04217283
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.03898275
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.02741501
105TCF4_22108803_ChIP-Seq_LS180_Human1.02637194
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.02375557
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02263436
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02263436
109VDR_22108803_ChIP-Seq_LS180_Human1.01914620
110BCAT_22108803_ChIP-Seq_LS180_Human1.00547264
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00018407
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99144625
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98773827
114SMAD4_21741376_ChIP-Seq_EPCs_Human0.97636513
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.96981896
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96126355
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94351720
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.94310572
119KDM2B_26808549_Chip-Seq_REH_Human0.92679362
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.92221017
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91611686
122ER_23166858_ChIP-Seq_MCF-7_Human0.91370476
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89360520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.33775282
2MP0003880_abnormal_central_pattern5.94850781
3MP0003635_abnormal_synaptic_transmissio4.33969778
4MP0004270_analgesia3.93863036
5MP0009745_abnormal_behavioral_response3.63264487
6* MP0002063_abnormal_learning/memory/cond3.58832110
7MP0002064_seizures3.21848193
8MP0001968_abnormal_touch/_nociception3.03977389
9MP0002572_abnormal_emotion/affect_behav3.00732539
10MP0009046_muscle_twitch2.79456662
11MP0001501_abnormal_sleep_pattern2.69739994
12MP0002272_abnormal_nervous_system2.68983535
13MP0002735_abnormal_chemical_nociception2.59195622
14MP0002736_abnormal_nociception_after2.57036857
15MP0001486_abnormal_startle_reflex2.47921834
16MP0005423_abnormal_somatic_nervous2.31089388
17MP0002734_abnormal_mechanical_nocicepti2.30968637
18MP0001440_abnormal_grooming_behavior2.27171533
19MP0002822_catalepsy2.11777057
20MP0000534_abnormal_ureter_morphology1.98296761
21MP0002067_abnormal_sensory_capabilities1.94887316
22MP0003329_amyloid_beta_deposits1.93268495
23MP0005248_abnormal_Harderian_gland1.82797039
24MP0000778_abnormal_nervous_system1.82661209
25MP0002184_abnormal_innervation1.81427154
26MP0003787_abnormal_imprinting1.77594236
27MP0005187_abnormal_penis_morphology1.77590953
28MP0002733_abnormal_thermal_nociception1.77386392
29MP0001970_abnormal_pain_threshold1.75434124
30MP0009780_abnormal_chondrocyte_physiolo1.74328768
31MP0004858_abnormal_nervous_system1.70197674
32MP0002557_abnormal_social/conspecific_i1.65601868
33MP0000537_abnormal_urethra_morphology1.64406599
34MP0004811_abnormal_neuron_physiology1.63682556
35MP0000566_synostosis1.63254475
36MP0006276_abnormal_autonomic_nervous1.63023743
37MP0003879_abnormal_hair_cell1.62278378
38MP0008569_lethality_at_weaning1.62024251
39MP0004924_abnormal_behavior1.60294534
40MP0005386_behavior/neurological_phenoty1.60294534
41MP0006072_abnormal_retinal_apoptosis1.57069250
42MP0000462_abnormal_digestive_system1.53289513
43MP0005646_abnormal_pituitary_gland1.52753885
44MP0001529_abnormal_vocalization1.52048386
45MP0002249_abnormal_larynx_morphology1.47856445
46MP0008057_abnormal_DNA_replication1.46952043
47MP0002909_abnormal_adrenal_gland1.45719977
48MP0000955_abnormal_spinal_cord1.44185468
49MP0003937_abnormal_limbs/digits/tail_de1.44169465
50MP0001188_hyperpigmentation1.41959321
51MP0009053_abnormal_anal_canal1.41649324
52MP0003942_abnormal_urinary_system1.41252182
53MP0002066_abnormal_motor_capabilities/c1.36933706
54MP0002882_abnormal_neuron_morphology1.36391623
55MP0010030_abnormal_orbit_morphology1.34656954
56MP0001905_abnormal_dopamine_level1.34045826
57MP0003633_abnormal_nervous_system1.33492274
58MP0005253_abnormal_eye_physiology1.28311162
59MP0004885_abnormal_endolymph1.25910723
60MP0002009_preneoplasia1.22268509
61MP0000049_abnormal_middle_ear1.21889532
62MP0000538_abnormal_urinary_bladder1.20393226
63MP0001293_anophthalmia1.20047676
64MP0001984_abnormal_olfaction1.18634578
65MP0003631_nervous_system_phenotype1.17521799
66MP0002837_dystrophic_cardiac_calcinosis1.17493764
67MP0004142_abnormal_muscle_tone1.14232358
68MP0004133_heterotaxia1.12703171
69MP0003121_genomic_imprinting1.10992028
70MP0005645_abnormal_hypothalamus_physiol1.09470390
71MP0005670_abnormal_white_adipose1.09046319
72MP0001502_abnormal_circadian_rhythm1.09013692
73MP0002233_abnormal_nose_morphology1.07730684
74MP0002160_abnormal_reproductive_system1.05831738
75MP0004510_myositis1.05047160
76MP0002152_abnormal_brain_morphology1.05043007
77MP0002938_white_spotting1.02677405
78MP0002751_abnormal_autonomic_nervous1.01701595
79MP0005409_darkened_coat_color1.00223502
80MP0003698_abnormal_male_reproductive1.00017581
81MP0000751_myopathy0.96713952
82MP0010386_abnormal_urinary_bladder0.96625618
83MP0003122_maternal_imprinting0.95464268
84MP0003283_abnormal_digestive_organ0.95158160
85MP0004145_abnormal_muscle_electrophysio0.94756098
86MP0004484_altered_response_of0.93904996
87MP0000579_abnormal_nail_morphology0.93712997
88MP0000427_abnormal_hair_cycle0.93339836
89MP0008874_decreased_physiological_sensi0.92444848
90MP0004134_abnormal_chest_morphology0.91442092
91MP0003119_abnormal_digestive_system0.90338804
92MP0002697_abnormal_eye_size0.89703334
93MP0003938_abnormal_ear_development0.89408586
94MP0002229_neurodegeneration0.88951083
95MP0000604_amyloidosis0.88562943
96MP0002069_abnormal_eating/drinking_beha0.88343352
97MP0005391_vision/eye_phenotype0.88281930
98MP0008872_abnormal_physiological_respon0.88153106
99MP0005410_abnormal_fertilization0.87415502
100MP0001963_abnormal_hearing_physiology0.87008142
101MP0004085_abnormal_heartbeat0.86091840
102MP0003632_abnormal_nervous_system0.82981885
103MP0004215_abnormal_myocardial_fiber0.81064831
104MP0002127_abnormal_cardiovascular_syste0.80822480
105MP0002090_abnormal_vision0.80808132
106MP0004742_abnormal_vestibular_system0.80709280
107MP0003075_altered_response_to0.80301287
108MP0002081_perinatal_lethality0.77999440
109MP0005551_abnormal_eye_electrophysiolog0.77139415
110MP0003693_abnormal_embryo_hatching0.76598075
111MP0006292_abnormal_olfactory_placode0.76308010
112MP0005535_abnormal_body_temperature0.76252119
113MP0002102_abnormal_ear_morphology0.76245822
114MP0002653_abnormal_ependyma_morphology0.75165581
115MP0002876_abnormal_thyroid_physiology0.75070305
116MP0008877_abnormal_DNA_methylation0.74142268
117MP0001177_atelectasis0.73677913
118MP0002752_abnormal_somatic_nervous0.70671762
119MP0003634_abnormal_glial_cell0.70111119
120MP0001485_abnormal_pinna_reflex0.67728583
121MP0001664_abnormal_digestion0.67221857
122MP0000569_abnormal_digit_pigmentation0.64744639
123MP0002234_abnormal_pharynx_morphology0.63648085
124MP0000920_abnormal_myelination0.62563344
125MP0000631_abnormal_neuroendocrine_gland0.61758826
126MP0005499_abnormal_olfactory_system0.60205311
127MP0005394_taste/olfaction_phenotype0.60205311
128MP0004233_abnormal_muscle_weight0.59962812
129MP0001765_abnormal_ion_homeostasis0.59530955
130MP0003646_muscle_fatigue0.57165080
131MP0003137_abnormal_impulse_conducting0.57099216
132MP0005623_abnormal_meninges_morphology0.55087067
133MP0003690_abnormal_glial_cell0.54494779
134MP0005171_absent_coat_pigmentation0.53279827
135MP0000013_abnormal_adipose_tissue0.53276143
136MP0000026_abnormal_inner_ear0.52512365
137MP0003861_abnormal_nervous_system0.52249256
138MP0003123_paternal_imprinting0.51722638
139MP0005595_abnormal_vascular_smooth0.50388249
140MP0001943_abnormal_respiration0.48099426

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.39282369
2Myokymia (HP:0002411)6.96171816
3Focal seizures (HP:0007359)6.22759587
4Epileptic encephalopathy (HP:0200134)5.35592843
5Atonic seizures (HP:0010819)5.34108220
6Febrile seizures (HP:0002373)5.12041195
7Absence seizures (HP:0002121)4.83451443
8Visual hallucinations (HP:0002367)4.79498448
9Hyperventilation (HP:0002883)4.78622588
10Dialeptic seizures (HP:0011146)4.48304736
11Progressive cerebellar ataxia (HP:0002073)4.38603733
12Generalized tonic-clonic seizures (HP:0002069)4.12269119
13Action tremor (HP:0002345)3.88947669
14Broad-based gait (HP:0002136)3.85170176
15Amblyopia (HP:0000646)3.67179240
16Abnormality of the phalanges of the hallux (HP:0010057)3.50817197
17Supranuclear gaze palsy (HP:0000605)3.43390675
18Gaze-evoked nystagmus (HP:0000640)3.42988755
19Dysmetria (HP:0001310)3.39691570
20Impaired vibration sensation in the lower limbs (HP:0002166)3.39254770
21Drooling (HP:0002307)3.34892963
22Excessive salivation (HP:0003781)3.34892963
23Truncal ataxia (HP:0002078)3.26794422
24Poor eye contact (HP:0000817)3.25233619
25Cerebral inclusion bodies (HP:0100314)3.11299376
26Dysdiadochokinesis (HP:0002075)3.09878005
27Impaired social interactions (HP:0000735)3.05263787
28Abnormal social behavior (HP:0012433)3.05263787
29Cutaneous finger syndactyly (HP:0010554)3.05207656
30Epileptiform EEG discharges (HP:0011182)3.02258414
31Abnormality of the 4th metacarpal (HP:0010012)2.98631575
32Depression (HP:0000716)2.94417696
33Anxiety (HP:0000739)2.92579746
34Preaxial foot polydactyly (HP:0001841)2.91800225
35Impaired smooth pursuit (HP:0007772)2.88791498
36Scanning speech (HP:0002168)2.82719582
37Diplopia (HP:0000651)2.79482675
38Abnormality of binocular vision (HP:0011514)2.79482675
39Neurofibrillary tangles (HP:0002185)2.79359496
40Urinary bladder sphincter dysfunction (HP:0002839)2.76945627
41Postural instability (HP:0002172)2.74955673
42Postaxial foot polydactyly (HP:0001830)2.74954637
43Hemiparesis (HP:0001269)2.74621552
44Bicornuate uterus (HP:0000813)2.72096353
45Absent speech (HP:0001344)2.70871207
46Abnormality of the lower motor neuron (HP:0002366)2.67610981
47Abnormality of the astrocytes (HP:0100707)2.66358366
48Astrocytoma (HP:0009592)2.66358366
49Renal dysplasia (HP:0000110)2.65920605
50Progressive inability to walk (HP:0002505)2.65618172
51Colon cancer (HP:0003003)2.62122068
52Abnormal eating behavior (HP:0100738)2.58498089
53Hepatoblastoma (HP:0002884)2.58194108
54Genetic anticipation (HP:0003743)2.55039210
55EEG with generalized epileptiform discharges (HP:0011198)2.52480166
56Termporal pattern (HP:0011008)2.52220451
57Insidious onset (HP:0003587)2.52220451
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51082420
59Short 4th metacarpal (HP:0010044)2.51082420
60Gait imbalance (HP:0002141)2.48441013
61Mutism (HP:0002300)2.47422927
62Abnormality of abdominal situs (HP:0011620)2.43787230
63Abdominal situs inversus (HP:0003363)2.43787230
64Abnormal ciliary motility (HP:0012262)2.43480148
65Ankle clonus (HP:0011448)2.42962438
66Vaginal atresia (HP:0000148)2.42959177
67Absent radius (HP:0003974)2.42905049
68Cutaneous syndactyly (HP:0012725)2.42463514
69Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41599509
70Bradykinesia (HP:0002067)2.40774625
71Inability to walk (HP:0002540)2.38492751
72Pancreatic fibrosis (HP:0100732)2.38047296
73True hermaphroditism (HP:0010459)2.37863724
74Urinary urgency (HP:0000012)2.36902776
75Genital tract atresia (HP:0001827)2.36872956
76Impaired vibratory sensation (HP:0002495)2.35522330
77Occipital encephalocele (HP:0002085)2.34704686
78Fetal akinesia sequence (HP:0001989)2.34466219
79Stereotypic behavior (HP:0000733)2.34261534
80Nephronophthisis (HP:0000090)2.33428154
81Abnormality of ocular smooth pursuit (HP:0000617)2.33301536
82Supernumerary spleens (HP:0009799)2.32983356
83Abnormality of salivation (HP:0100755)2.32572020
84Tented upper lip vermilion (HP:0010804)2.32081046
85Abnormal respiratory motile cilium physiology (HP:0012261)2.31568981
86Absent forearm bone (HP:0003953)2.31022571
87Aplasia involving forearm bones (HP:0009822)2.31022571
88Hypsarrhythmia (HP:0002521)2.30632596
89Hydroureter (HP:0000072)2.29070461
90Intention tremor (HP:0002080)2.28966862
91Pancreatic cysts (HP:0001737)2.26995246
92Facial hemangioma (HP:0000329)2.26905957
93Status epilepticus (HP:0002133)2.25870370
94Congenital primary aphakia (HP:0007707)2.24717812
95Postaxial hand polydactyly (HP:0001162)2.24104824
96Abnormality of the labia minora (HP:0012880)2.22839959
97Delusions (HP:0000746)2.22799284
98Protruding tongue (HP:0010808)2.22185202
99Generalized myoclonic seizures (HP:0002123)2.21627903
100Spastic gait (HP:0002064)2.20644063
101Anencephaly (HP:0002323)2.19961309
102High anterior hairline (HP:0009890)2.18142507
103Blue irides (HP:0000635)2.17473702
104Medial flaring of the eyebrow (HP:0010747)2.17276386
105Focal dystonia (HP:0004373)2.14224473
106Type II lissencephaly (HP:0007260)2.13723059
107Glioma (HP:0009733)2.10938095
108Torticollis (HP:0000473)2.06622562
109Incomplete penetrance (HP:0003829)2.05496399
110Poor coordination (HP:0002370)2.05484664
111Broad distal phalanx of finger (HP:0009836)2.04929432
112Hemiplegia (HP:0002301)2.04537082
113Ectopic kidney (HP:0000086)2.04116389
114Dysmetric saccades (HP:0000641)2.03985155
115Nephrogenic diabetes insipidus (HP:0009806)2.03892972
116Aqueductal stenosis (HP:0002410)2.01404801
117Abnormality of the corticospinal tract (HP:0002492)2.00600010
118Thickened helices (HP:0000391)2.00013824
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.99894657
120Volvulus (HP:0002580)1.99676694
121Abnormality of the proximal phalanges of the hand (HP:0009834)1.98694406
122Gait ataxia (HP:0002066)1.95599595
123Abnormality of the renal medulla (HP:0100957)1.94436433
124Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93487587
125Retinal dysplasia (HP:0007973)1.92900293
126Preaxial hand polydactyly (HP:0001177)1.92763355
127Abnormality of the middle phalanges of the toes (HP:0010183)1.92703285
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.92531844
129Lower limb muscle weakness (HP:0007340)1.90703229
130Psychosis (HP:0000709)1.90655652
131Midline defect of the nose (HP:0004122)1.90018140
132Lower limb amyotrophy (HP:0007210)1.86378657
133Pheochromocytoma (HP:0002666)1.85619462
134Abnormality of macular pigmentation (HP:0008002)1.85558040
135Papilledema (HP:0001085)1.85371598
136Syncope (HP:0001279)1.84350921
137Rapidly progressive (HP:0003678)1.82815886
138Megalencephaly (HP:0001355)1.81819822
139Increased circulating renin level (HP:0000848)1.81454015
140Fair hair (HP:0002286)1.80444612
141Annular pancreas (HP:0001734)1.80425220
142Abnormality of the pubic bones (HP:0003172)1.80206154
143Sclerocornea (HP:0000647)1.79101504
144Widely spaced teeth (HP:0000687)1.77674745
145Generalized hypopigmentation of hair (HP:0011358)1.75584751
146Testicular atrophy (HP:0000029)1.75232149
147Broad foot (HP:0001769)1.74463680
148Ventricular fibrillation (HP:0001663)1.74412820
149Abnormality of the aortic arch (HP:0012303)1.74391128
150Gastroesophageal reflux (HP:0002020)1.74232031
151Chronic hepatic failure (HP:0100626)1.73337070
152Omphalocele (HP:0001539)1.72728808
153Lower limb asymmetry (HP:0100559)1.72623558
154Decreased circulating renin level (HP:0003351)1.72578551
155Craniofacial dystonia (HP:0012179)1.72103972
156Anal atresia (HP:0002023)1.71566933
157Large earlobe (HP:0009748)1.71180252
158Renal hypoplasia (HP:0000089)1.70542406
159Cystic liver disease (HP:0006706)1.70316650
160Inappropriate behavior (HP:0000719)1.69675787
161Abnormal EKG (HP:0003115)1.68554710
162Short chin (HP:0000331)1.68476919
163Tubulointerstitial nephritis (HP:0001970)1.68243414
164Autism (HP:0000717)1.68006186
165Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67087594
166Neuronal loss in central nervous system (HP:0002529)1.67040659
167Fibular aplasia (HP:0002990)1.66453607
168Capillary hemangiomas (HP:0005306)1.66421816
169Smooth philtrum (HP:0000319)1.62319994
170Anophthalmia (HP:0000528)1.61929629
171Bifid tongue (HP:0010297)1.61049982
172Central scotoma (HP:0000603)1.59578475
173Short metatarsal (HP:0010743)1.58691805
174Bifid scrotum (HP:0000048)1.58473071
175Abnormality of the parathyroid morphology (HP:0011766)1.57727986
176Short 5th finger (HP:0009237)1.56293725
177Abnormality of midbrain morphology (HP:0002418)1.54941101

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.81407324
2NTRK35.51203076
3MAP3K93.07215587
4RIPK43.03064500
5CCNB12.91325593
6MAP3K42.85855288
7FRK2.80443539
8LATS12.73005606
9CASK2.61241177
10MINK12.57058572
11MAP4K22.55492566
12MAP2K72.34677987
13MARK12.29843222
14DAPK12.16795976
15MAP3K122.04770533
16DAPK21.93731612
17NTRK11.92867074
18NTRK21.92553387
19KSR21.91009199
20CAMK1D1.89898100
21KSR11.82654556
22PRKD31.79094728
23PLK41.75310241
24NEK11.73944940
25PLK21.72333978
26PAK61.70882101
27MAP2K41.67665375
28ACVR1B1.62394445
29PRPF4B1.62120637
30TNIK1.61675500
31NUAK11.52529966
32BMPR21.51840174
33CDK51.46419603
34PTK2B1.44908711
35CAMK2B1.43931208
36CDC71.41147218
37CAMKK11.39116246
38SRPK11.38547248
39PRKCG1.34185061
40PNCK1.33896889
41FES1.33895081
42CAMK2A1.33446676
43NME11.33399311
44MAP3K131.33154445
45ARAF1.31326103
46MAPK131.28231825
47GRK51.26760222
48SIK21.25184903
49PKN21.21000358
50MKNK21.14298371
51CAMK41.14093534
52STK381.11049908
53CSNK1G31.08024137
54BMPR1B1.06711133
55BRD41.06355581
56RAF11.05269093
57CSNK1A1L1.04569057
58DYRK21.03416372
59CSNK1G10.99587345
60MYLK0.94321865
61MKNK10.92632727
62CDK190.92516501
63INSRR0.91829340
64CAMK10.86679254
65RPS6KA40.86367402
66MAP3K20.86192864
67FGR0.86075045
68BCKDK0.83158203
69ERBB30.82986464
70AKT30.82908826
71LATS20.80976289
72SGK20.80832755
73SGK10.80456286
74SGK2230.79882966
75SGK4940.79882966
76CDK180.78789070
77CDK150.73806659
78CAMKK20.73521537
79TYRO30.72745483
80DYRK30.71720114
81EPHB20.71136459
82MAP3K70.70438700
83IRAK20.70347214
84CDK140.69761333
85SIK30.69203771
86PIK3CA0.68698111
87PAK30.68415590
88ZAK0.67255558
89MUSK0.64692779
90FER0.64502118
91EPHA30.64473736
92CAMK2D0.63915789
93CDK11A0.62757066
94STK110.62509292
95PDK10.60105863
96DYRK1A0.59060438
97OXSR10.58695794
98CDK30.58173913
99PRKCE0.57479205
100UHMK10.56916602
101SGK30.55952005
102BRAF0.53701537
103GRK70.53538053
104MARK20.52867244
105NEK20.52250514
106PRKCH0.50803519
107RET0.50663334
108WNK30.49634891
109CSNK1G20.49132065
110FYN0.48660261
111PDPK10.46597791
112CSNK1E0.46590280
113CAMK2G0.46490553
114RPS6KA30.45794048
115DMPK0.44662278
116PHKG10.44563022
117PHKG20.44563022
118PRKCZ0.44013625
119MAP3K60.43836526
120MAPK70.43419435
121PKN10.42662150
122ATM0.42450925
123CSNK1A10.42151539
124BCR0.42085669
125LMTK20.41862539
126PRKACB0.41333597
127MAPK100.40539676
128MAP2K10.40391896
129PINK10.40327895
130MAP3K100.38670940
131CSNK1D0.38537892
132ROCK20.38061289
133TNK20.37947408
134NEK60.37788167
135MAP3K10.37469880
136PRKCQ0.37104407
137TAOK10.36843546
138GRK60.35180358
139DYRK1B0.33972277
140MOS0.33784180
141CAMK1G0.33363064
142PRKCA0.33189758
143PRKCB0.33134684
144EEF2K0.33111289
145GSK3B0.32781486
146PRKDC0.32771225
147STK390.31293588
148ILK0.31023379
149GRK10.28976533
150CDK10.26197040
151ATR0.26168185
152IRAK10.25111762
153PRKACA0.24588198

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.49355899
2Long-term potentiation_Homo sapiens_hsa047203.25561780
3Circadian entrainment_Homo sapiens_hsa047133.00698350
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89409749
5Amphetamine addiction_Homo sapiens_hsa050312.87726767
6Glutamatergic synapse_Homo sapiens_hsa047242.87004850
7Synaptic vesicle cycle_Homo sapiens_hsa047212.67244812
8GABAergic synapse_Homo sapiens_hsa047272.60806916
9Olfactory transduction_Homo sapiens_hsa047402.55514225
10Morphine addiction_Homo sapiens_hsa050322.54664223
11Salivary secretion_Homo sapiens_hsa049702.49786537
12Dopaminergic synapse_Homo sapiens_hsa047282.24743483
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14304615
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97905482
15Taste transduction_Homo sapiens_hsa047421.94846421
16Insulin secretion_Homo sapiens_hsa049111.92455156
17Calcium signaling pathway_Homo sapiens_hsa040201.91284413
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90418627
19Gastric acid secretion_Homo sapiens_hsa049711.87639058
20Long-term depression_Homo sapiens_hsa047301.86704167
21Fatty acid biosynthesis_Homo sapiens_hsa000611.84379773
22Cholinergic synapse_Homo sapiens_hsa047251.84166996
23Renin secretion_Homo sapiens_hsa049241.82120345
24Serotonergic synapse_Homo sapiens_hsa047261.79732015
25Oxytocin signaling pathway_Homo sapiens_hsa049211.75158821
26Cocaine addiction_Homo sapiens_hsa050301.63297715
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55855614
28Collecting duct acid secretion_Homo sapiens_hsa049661.45245452
29Propanoate metabolism_Homo sapiens_hsa006401.43627766
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43304049
31GnRH signaling pathway_Homo sapiens_hsa049121.42864700
32Butanoate metabolism_Homo sapiens_hsa006501.41904837
33cAMP signaling pathway_Homo sapiens_hsa040241.38818691
34Gap junction_Homo sapiens_hsa045401.30448103
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24535492
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24498939
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24046127
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22440853
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.19946081
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16403389
41Glioma_Homo sapiens_hsa052141.15735905
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15126774
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13968784
44Estrogen signaling pathway_Homo sapiens_hsa049151.12610357
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11431241
46* Axon guidance_Homo sapiens_hsa043601.10843071
47Basal transcription factors_Homo sapiens_hsa030221.03743342
48Melanogenesis_Homo sapiens_hsa049161.03710959
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.03484381
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02984402
51Type II diabetes mellitus_Homo sapiens_hsa049301.01332424
52Pancreatic secretion_Homo sapiens_hsa049720.98061189
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96846955
54Cardiac muscle contraction_Homo sapiens_hsa042600.94261221
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93577572
56ErbB signaling pathway_Homo sapiens_hsa040120.93131140
57Hedgehog signaling pathway_Homo sapiens_hsa043400.92467843
58Vibrio cholerae infection_Homo sapiens_hsa051100.90330600
59Phototransduction_Homo sapiens_hsa047440.89272993
60Fanconi anemia pathway_Homo sapiens_hsa034600.88003014
61Hippo signaling pathway_Homo sapiens_hsa043900.87054962
62Oocyte meiosis_Homo sapiens_hsa041140.86980642
63Non-homologous end-joining_Homo sapiens_hsa034500.84893627
64Choline metabolism in cancer_Homo sapiens_hsa052310.83379099
65RNA degradation_Homo sapiens_hsa030180.81897404
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.80873252
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79459456
68Fatty acid metabolism_Homo sapiens_hsa012120.78765478
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.78686935
70One carbon pool by folate_Homo sapiens_hsa006700.78478622
71Steroid biosynthesis_Homo sapiens_hsa001000.77900329
72Thyroid hormone synthesis_Homo sapiens_hsa049180.75457882
73Lysine degradation_Homo sapiens_hsa003100.71995680
74Dilated cardiomyopathy_Homo sapiens_hsa054140.69419282
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69104304
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68848914
77mRNA surveillance pathway_Homo sapiens_hsa030150.68662203
78VEGF signaling pathway_Homo sapiens_hsa043700.68197186
79African trypanosomiasis_Homo sapiens_hsa051430.67151131
80MAPK signaling pathway_Homo sapiens_hsa040100.66579784
81Purine metabolism_Homo sapiens_hsa002300.66398379
82Dorso-ventral axis formation_Homo sapiens_hsa043200.66243107
83RNA transport_Homo sapiens_hsa030130.65008288
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64909702
85Homologous recombination_Homo sapiens_hsa034400.64809951
86Ras signaling pathway_Homo sapiens_hsa040140.64596882
87RNA polymerase_Homo sapiens_hsa030200.63673371
88Glucagon signaling pathway_Homo sapiens_hsa049220.62549618
89Alzheimers disease_Homo sapiens_hsa050100.61802349
90Tight junction_Homo sapiens_hsa045300.61453488
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61044322
92Rap1 signaling pathway_Homo sapiens_hsa040150.60898524
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60371549
94Colorectal cancer_Homo sapiens_hsa052100.58962067
95Huntingtons disease_Homo sapiens_hsa050160.58771403
96TGF-beta signaling pathway_Homo sapiens_hsa043500.58205679
97Endometrial cancer_Homo sapiens_hsa052130.56914905
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56467993
99Basal cell carcinoma_Homo sapiens_hsa052170.56245992
100AMPK signaling pathway_Homo sapiens_hsa041520.52630683
101Sulfur relay system_Homo sapiens_hsa041220.50363276
102Vitamin B6 metabolism_Homo sapiens_hsa007500.50102934
103Melanoma_Homo sapiens_hsa052180.49535787
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47727356
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47552492
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46967239
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.46029595
108Fatty acid elongation_Homo sapiens_hsa000620.45616271
109Inositol phosphate metabolism_Homo sapiens_hsa005620.45210995
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45180833
111Alcoholism_Homo sapiens_hsa050340.42906267
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42755114
113Selenocompound metabolism_Homo sapiens_hsa004500.42389796
114Peroxisome_Homo sapiens_hsa041460.40609655
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.40360556
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40232875
117Bile secretion_Homo sapiens_hsa049760.40043517
118mTOR signaling pathway_Homo sapiens_hsa041500.39554898
119Wnt signaling pathway_Homo sapiens_hsa043100.39407949
120Non-small cell lung cancer_Homo sapiens_hsa052230.35104256
121Ovarian steroidogenesis_Homo sapiens_hsa049130.33397819
122Type I diabetes mellitus_Homo sapiens_hsa049400.32848360
123Nitrogen metabolism_Homo sapiens_hsa009100.32375795
124Circadian rhythm_Homo sapiens_hsa047100.32160929
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31860941
126Prion diseases_Homo sapiens_hsa050200.31783823
127Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31370442
128Endocytosis_Homo sapiens_hsa041440.30680525
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28050400
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26798533
131Mineral absorption_Homo sapiens_hsa049780.26779561
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26692355
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26445801
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23792633
135Oxidative phosphorylation_Homo sapiens_hsa001900.22349477
136Insulin signaling pathway_Homo sapiens_hsa049100.21911190
137Chemokine signaling pathway_Homo sapiens_hsa040620.21407729
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21231201
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.19144660
140Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19119911

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