EPHA8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)8.57263756
2positive regulation of gastrulation (GO:2000543)6.64178549
3synaptic vesicle maturation (GO:0016188)6.29263146
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28883314
5neuron fate determination (GO:0048664)5.69037026
6primitive streak formation (GO:0090009)5.38304926
7response to pheromone (GO:0019236)5.23886750
8locomotory exploration behavior (GO:0035641)5.17937489
9layer formation in cerebral cortex (GO:0021819)4.87466875
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.81609117
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75270073
12regulation of synaptic vesicle exocytosis (GO:2000300)4.74401782
13somite rostral/caudal axis specification (GO:0032525)4.58115451
14synaptic vesicle exocytosis (GO:0016079)4.37540568
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.32433296
16peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.29977950
17establishment of mitochondrion localization (GO:0051654)4.28508018
18sodium ion export (GO:0071436)4.24887037
19protein localization to synapse (GO:0035418)4.22263809
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.18966827
21behavioral response to nicotine (GO:0035095)4.08822830
22neurotransmitter secretion (GO:0007269)4.07886585
23regulation of clathrin-mediated endocytosis (GO:2000369)4.07834792
24vocalization behavior (GO:0071625)4.05883315
25viral transcription (GO:0019083)4.02549302
26cerebellar Purkinje cell differentiation (GO:0021702)4.01350195
27pyrimidine nucleobase catabolic process (GO:0006208)3.99585569
28cellular potassium ion homeostasis (GO:0030007)3.98603141
29ribosomal small subunit biogenesis (GO:0042274)3.97985449
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91009538
31regulation of synaptic vesicle transport (GO:1902803)3.88471535
32positive regulation of protein homodimerization activity (GO:0090073)3.88381538
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.86627363
34mitochondrion transport along microtubule (GO:0047497)3.86627363
35regulation of protein heterodimerization activity (GO:0043497)3.82843643
36dendritic spine morphogenesis (GO:0060997)3.81845501
37positive regulation of vesicle fusion (GO:0031340)3.79889817
38positive regulation of synapse maturation (GO:0090129)3.77205713
39regulation of calcium ion-dependent exocytosis (GO:0017158)3.74682668
40translational termination (GO:0006415)3.73468231
41glutamate secretion (GO:0014047)3.70539977
42regulation of vesicle fusion (GO:0031338)3.68765906
43prepulse inhibition (GO:0060134)3.68195404
44regulation of glutamate receptor signaling pathway (GO:1900449)3.65145553
45membrane depolarization during action potential (GO:0086010)3.60117079
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.59565241
47potassium ion import (GO:0010107)3.57579407
48epithelial cell fate commitment (GO:0072148)3.56664270
49synaptic transmission, glutamatergic (GO:0035249)3.54048143
50maturation of SSU-rRNA (GO:0030490)3.50564286
51innervation (GO:0060384)3.50044223
52exploration behavior (GO:0035640)3.48463328
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43780084
54cerebellar granule cell differentiation (GO:0021707)3.42278225
55postsynaptic membrane organization (GO:0001941)3.42127763
56photoreceptor cell development (GO:0042461)3.41892437
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.41176304
58hypothalamus development (GO:0021854)3.40202757
59cell communication by electrical coupling (GO:0010644)3.40021120
60establishment of protein localization to mitochondrial membrane (GO:0090151)3.39555681
61cerebellum development (GO:0021549)3.39553753
62positive regulation of membrane potential (GO:0045838)3.36946650
63glutamate receptor signaling pathway (GO:0007215)3.36553327
64neuron cell-cell adhesion (GO:0007158)3.36084812
65eye photoreceptor cell development (GO:0042462)3.33273096
66regulation of type B pancreatic cell apoptotic process (GO:2000674)3.30983930
67regulation of neuronal synaptic plasticity (GO:0048168)3.29504591
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27861462
69ATP synthesis coupled proton transport (GO:0015986)3.27861462
70neurotransmitter-gated ion channel clustering (GO:0072578)3.25061064
71neuromuscular process controlling balance (GO:0050885)3.24290090
72gamma-aminobutyric acid transport (GO:0015812)3.23029701
73translational elongation (GO:0006414)3.22616855
74neuron-neuron synaptic transmission (GO:0007270)3.21722191
75glucocorticoid biosynthetic process (GO:0006704)3.21244140
76membrane repolarization (GO:0086009)3.21182241
77regulation of synapse structural plasticity (GO:0051823)3.19984229
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.19877047
79dendrite morphogenesis (GO:0048813)3.19221467
80neurotransmitter transport (GO:0006836)3.19078593
81synaptic vesicle endocytosis (GO:0048488)3.18237915
82cell migration in hindbrain (GO:0021535)3.16538184
83photoreceptor cell maintenance (GO:0045494)3.16288928
84membrane hyperpolarization (GO:0060081)3.16068170
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15888268
86positive regulation of exocytosis (GO:0045921)3.15443665
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.14260099
88positive regulation of neurotransmitter secretion (GO:0001956)3.13280919
89mating behavior (GO:0007617)3.06114171
90regulation of neurotransmitter secretion (GO:0046928)3.05690292
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05588315
92pre-miRNA processing (GO:0031054)3.05511752
93cell differentiation in hindbrain (GO:0021533)3.03744408
94glycine transport (GO:0015816)3.03400175
95cranial nerve morphogenesis (GO:0021602)3.03330761
96GTP biosynthetic process (GO:0006183)3.01472071
97UTP biosynthetic process (GO:0006228)3.01420386
98neuronal action potential propagation (GO:0019227)3.00713189
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98936137
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97725214
101peptidyl-lysine dimethylation (GO:0018027)2.96770473
102regulation of postsynaptic membrane potential (GO:0060078)2.96591117
103mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.95760945
104calcium ion import (GO:0070509)2.95596877
105SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94106738
106nucleobase catabolic process (GO:0046113)2.92666256
107cotranslational protein targeting to membrane (GO:0006613)2.92260807
108regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91467305
109negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.90512154
110establishment of nucleus localization (GO:0040023)2.89809616
111long-term memory (GO:0007616)2.88681691
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88599329
113positive regulation of neurotransmitter transport (GO:0051590)2.87893515
114protein targeting to ER (GO:0045047)2.87756999
115axonal fasciculation (GO:0007413)2.87280181
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87136198
117cellular protein complex disassembly (GO:0043624)2.86794795
118auditory behavior (GO:0031223)2.86570787
119neuron recognition (GO:0008038)2.86015808
120positive regulation of transcription regulatory region DNA binding (GO:2000679)2.85195367
121viral life cycle (GO:0019058)2.84989969
122regulation of mitochondrial translation (GO:0070129)2.84388645
123potassium ion homeostasis (GO:0055075)2.84115446
124regulation of chromatin binding (GO:0035561)2.83276171
125regulation of neurotransmitter levels (GO:0001505)2.82901695
126presynaptic membrane assembly (GO:0097105)2.82214473
127regulation of ARF protein signal transduction (GO:0032012)2.81275005
128negative regulation of JAK-STAT cascade (GO:0046426)2.80638978
129ribosomal small subunit assembly (GO:0000028)2.80580550
130regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.79645879
131regulation of mitotic spindle checkpoint (GO:1903504)2.79645879
132establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79118328
133membrane depolarization (GO:0051899)2.79071407
134neurofilament cytoskeleton organization (GO:0060052)2.77608850
135transmission of nerve impulse (GO:0019226)2.77530420
136detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.76075072
137detection of temperature stimulus involved in sensory perception (GO:0050961)2.76075072
138protein complex disassembly (GO:0043241)2.74279943
139UTP metabolic process (GO:0046051)2.73598816
140positive regulation of synapse assembly (GO:0051965)2.72218116
141pyrimidine nucleotide catabolic process (GO:0006244)2.71813698
142guanosine-containing compound biosynthetic process (GO:1901070)2.70114663
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69782878
144oocyte development (GO:0048599)2.69667074
145chaperone-mediated protein transport (GO:0072321)2.69145534
146protein localization to endoplasmic reticulum (GO:0070972)2.64550746
147translational initiation (GO:0006413)2.63911621
148heterochromatin organization (GO:0070828)2.62914513
149macromolecular complex disassembly (GO:0032984)2.59554466
150pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.58984546
151positive regulation by host of viral transcription (GO:0043923)2.54606459
152peptidyl-histidine modification (GO:0018202)2.52339377
153positive regulation of protein kinase C signaling (GO:0090037)2.52329123
154pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.49743393
155CTP metabolic process (GO:0046036)2.46740054
156CTP biosynthetic process (GO:0006241)2.46740054
157negative regulation of T cell differentiation in thymus (GO:0033085)2.46408204
158skeletal muscle organ development (GO:0060538)2.46215923
159respiratory electron transport chain (GO:0022904)2.44805994
160pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.44151941
161retinal cone cell development (GO:0046549)2.42524088
162presynaptic membrane organization (GO:0097090)2.42001264
163body morphogenesis (GO:0010171)2.41583766
164establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.41381807
165atrial cardiac muscle cell action potential (GO:0086014)2.40948338
166embryonic body morphogenesis (GO:0010172)2.40822203
167electron transport chain (GO:0022900)2.37719444
168protein complex biogenesis (GO:0070271)2.36831818
169regulation of synapse maturation (GO:0090128)2.36331319
170mitochondrial respiratory chain complex assembly (GO:0033108)2.35711098
171respiratory system process (GO:0003016)2.35528057
172regulation of gene silencing by miRNA (GO:0060964)2.34659253
173regulation of gene silencing by RNA (GO:0060966)2.34659253
174regulation of posttranscriptional gene silencing (GO:0060147)2.34659253
175urogenital system development (GO:0001655)2.34594915
176positive regulation of T cell apoptotic process (GO:0070234)2.33139693
177pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.31963131
178mechanosensory behavior (GO:0007638)2.31570401
179pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.30922422
180histone arginine methylation (GO:0034969)2.29912193
181positive regulation of cell cycle checkpoint (GO:1901978)2.29217168
182chromatin assembly (GO:0031497)2.29196131
183negative regulation of cell cycle arrest (GO:0071157)2.28467856
184NADH dehydrogenase complex assembly (GO:0010257)2.26141749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82883350
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.10360119
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.05671958
4* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.85014608
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.80213319
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67924745
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67924745
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.61761104
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.59223911
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.57772115
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56781248
12DROSHA_22980978_ChIP-Seq_HELA_Human2.53792027
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45350537
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.44137287
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43263979
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40555341
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.38349778
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.37388956
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.34096112
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32325626
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31985177
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.28354026
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25954046
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25418396
25KDM2B_26808549_Chip-Seq_K562_Human2.23935805
26* REST_18959480_ChIP-ChIP_MESCs_Mouse2.18831516
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14857025
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.13120389
29* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12719172
30MYC_18555785_ChIP-Seq_MESCs_Mouse2.08663770
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08314300
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07514877
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06616804
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04989343
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97552782
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94282875
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.91152450
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90849068
39GBX2_23144817_ChIP-Seq_PC3_Human1.83356203
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.78175297
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.76948019
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.76948019
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.76948019
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75277152
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.68981443
46XRN2_22483619_ChIP-Seq_HELA_Human1.67408396
47ZFP281_27345836_Chip-Seq_ESCs_Mouse1.64368927
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.62600148
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62344219
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.61487746
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59659621
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58677786
53E2F7_22180533_ChIP-Seq_HELA_Human1.54833754
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.54015807
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.53842005
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52462858
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52446977
58DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52269084
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49636367
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.49524679
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.49312427
62* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.47219370
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45196218
64* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.45130783
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44997381
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.44983020
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.44948819
68KDM2B_26808549_Chip-Seq_DND41_Human1.42674779
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.42258767
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40988423
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.38593429
72RNF2_27304074_Chip-Seq_NSC_Mouse1.38253376
73* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36746120
74* CTCF_27219007_Chip-Seq_Bcells_Human1.35999435
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33542487
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32001891
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29203056
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28101071
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28091356
80P68_20966046_ChIP-Seq_HELA_Human1.27410039
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26029280
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25003527
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23997220
84TTF2_22483619_ChIP-Seq_HELA_Human1.23957432
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21735183
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19995066
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19777998
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.19440603
89AR_19668381_ChIP-Seq_PC3_Human1.18303603
90CREB1_26743006_Chip-Seq_LNCaP_Human1.18098964
91AR_21572438_ChIP-Seq_LNCaP_Human1.17423755
92SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16951800
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16794778
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16374777
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15103525
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.14236187
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13779368
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13633108
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.13166710
100SMC4_20622854_ChIP-Seq_HELA_Human1.10647746
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.09387003
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08855837
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06322581
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03657614
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02771008
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02124385
107LXR_22292898_ChIP-Seq_THP-1_Human1.01571219
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00826232
109SOX2_21211035_ChIP-Seq_LN229_Gbm1.00014857
110TP53_16413492_ChIP-PET_HCT116_Human0.99820603
111KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99404994
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99220110
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98716496
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98518580
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98348610
116PHF8_20622854_ChIP-Seq_HELA_Human0.98281875
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97414200
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96542043
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96366863
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94555348
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94530573
122GABP_19822575_ChIP-Seq_HepG2_Human0.94126356
123ZNF274_21170338_ChIP-Seq_K562_Hela0.94092574
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92090905
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91386463
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91313482
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90979224
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90323565
129MYC_18940864_ChIP-ChIP_HL60_Human0.90028641
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89763482
131CBX2_27304074_Chip-Seq_ESCs_Mouse0.88561659
132TET1_21490601_ChIP-Seq_MESCs_Mouse0.88324865
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88151636
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87383297
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87053513
136YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86996617
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.86892552
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.86870413
139IRF1_19129219_ChIP-ChIP_H3396_Human0.86318702
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.85904456
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85901634
142KDM5A_27292631_Chip-Seq_BREAST_Human0.85839484
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.85654583
144GATA1_19941826_ChIP-Seq_K562_Human0.84826032
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84042806
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82959182
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79647900
148SMAD4_21799915_ChIP-Seq_A2780_Human0.79602760
149KLF4_19829295_ChIP-Seq_ESCs_Human0.78318106
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.78067262
151ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76274660
152OCT4_19829295_ChIP-Seq_ESCs_Human0.75975859
153AHR_22903824_ChIP-Seq_MCF-7_Human0.74067740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.40779599
2MP0010030_abnormal_orbit_morphology4.50889339
3MP0004859_abnormal_synaptic_plasticity4.09826805
4MP0006072_abnormal_retinal_apoptosis4.03207580
5MP0002234_abnormal_pharynx_morphology3.51335468
6MP0001188_hyperpigmentation3.34046032
7MP0004885_abnormal_endolymph3.19506496
8MP0005551_abnormal_eye_electrophysiolog3.11138828
9MP0005499_abnormal_olfactory_system3.10300199
10MP0005394_taste/olfaction_phenotype3.10300199
11MP0002653_abnormal_ependyma_morphology3.04079268
12MP0003635_abnormal_synaptic_transmissio2.91771456
13MP0001502_abnormal_circadian_rhythm2.91254564
14MP0008789_abnormal_olfactory_epithelium2.85901786
15MP0003890_abnormal_embryonic-extraembry2.68920090
16MP0009379_abnormal_foot_pigmentation2.40132384
17MP0004270_analgesia2.39868895
18MP0003136_yellow_coat_color2.26522272
19MP0005253_abnormal_eye_physiology2.23990201
20MP0003880_abnormal_central_pattern2.15650954
21MP0002063_abnormal_learning/memory/cond2.14116815
22MP0006276_abnormal_autonomic_nervous2.09303608
23MP0009046_muscle_twitch2.07846885
24MP0002064_seizures2.06611394
25MP0005423_abnormal_somatic_nervous2.05684588
26MP0009745_abnormal_behavioral_response2.04119067
27MP0003123_paternal_imprinting1.91568570
28MP0005195_abnormal_posterior_eye1.87279868
29MP0009780_abnormal_chondrocyte_physiolo1.87054719
30MP0001293_anophthalmia1.84763588
31MP0002734_abnormal_mechanical_nocicepti1.81939888
32MP0002272_abnormal_nervous_system1.75509315
33MP0003315_abnormal_perineum_morphology1.68548807
34MP0002184_abnormal_innervation1.65623096
35MP0001486_abnormal_startle_reflex1.64663921
36MP0000049_abnormal_middle_ear1.64607475
37MP0002160_abnormal_reproductive_system1.63763161
38MP0002163_abnormal_gland_morphology1.63506009
39MP0002822_catalepsy1.60802907
40* MP0000778_abnormal_nervous_system1.58839650
41MP0002572_abnormal_emotion/affect_behav1.54828527
42* MP0002882_abnormal_neuron_morphology1.53728374
43MP0002067_abnormal_sensory_capabilities1.50901302
44MP0003693_abnormal_embryo_hatching1.49112413
45MP0002229_neurodegeneration1.48477841
46MP0008569_lethality_at_weaning1.47716476
47MP0005391_vision/eye_phenotype1.46781394
48MP0000631_abnormal_neuroendocrine_gland1.46364832
49MP0002249_abnormal_larynx_morphology1.42535464
50MP0004811_abnormal_neuron_physiology1.42404595
51MP0000955_abnormal_spinal_cord1.42236256
52MP0001440_abnormal_grooming_behavior1.37116796
53MP0005409_darkened_coat_color1.36176345
54MP0001324_abnormal_eye_pigmentation1.34660812
55MP0000678_abnormal_parathyroid_gland1.33545565
56MP0003119_abnormal_digestive_system1.32932349
57MP0002557_abnormal_social/conspecific_i1.32606799
58MP0002752_abnormal_somatic_nervous1.31299739
59MP0001984_abnormal_olfaction1.31175753
60MP0003122_maternal_imprinting1.31114359
61MP0005645_abnormal_hypothalamus_physiol1.30609391
62MP0003942_abnormal_urinary_system1.29743942
63MP0003121_genomic_imprinting1.28645662
64MP0001968_abnormal_touch/_nociception1.28175941
65MP0002152_abnormal_brain_morphology1.26799067
66MP0004858_abnormal_nervous_system1.22809262
67MP0001529_abnormal_vocalization1.22757235
68MP0003329_amyloid_beta_deposits1.22014045
69MP0004133_heterotaxia1.21299833
70MP0005187_abnormal_penis_morphology1.19088800
71MP0008932_abnormal_embryonic_tissue1.17388047
72MP0004924_abnormal_behavior1.17034092
73MP0005386_behavior/neurological_phenoty1.17034092
74MP0003567_abnormal_fetal_cardiomyocyte1.16595815
75MP0002066_abnormal_motor_capabilities/c1.10926134
76MP0004145_abnormal_muscle_electrophysio1.10919031
77MP0002733_abnormal_thermal_nociception1.09210638
78MP0000566_synostosis1.08687800
79MP0003787_abnormal_imprinting1.08679587
80MP0001970_abnormal_pain_threshold1.07612410
81MP0004742_abnormal_vestibular_system1.06364720
82MP0003879_abnormal_hair_cell1.05763061
83MP0002697_abnormal_eye_size1.04944514
84MP0003633_abnormal_nervous_system1.03843172
85MP0002751_abnormal_autonomic_nervous1.02678224
86* MP0003861_abnormal_nervous_system1.01185241
87MP0001346_abnormal_lacrimal_gland1.00026201
88MP0005377_hearing/vestibular/ear_phenot0.98282263
89MP0003878_abnormal_ear_physiology0.98282263
90MP0002090_abnormal_vision0.97091995
91MP0001501_abnormal_sleep_pattern0.96755969
92MP0003634_abnormal_glial_cell0.96550572
93MP0005389_reproductive_system_phenotype0.95707672
94MP0002909_abnormal_adrenal_gland0.95125767
95MP0003632_abnormal_nervous_system0.95026856
96MP0004957_abnormal_blastocyst_morpholog0.94726147
97MP0002102_abnormal_ear_morphology0.93623844
98MP0005646_abnormal_pituitary_gland0.93286405
99MP0002210_abnormal_sex_determination0.92294386
100MP0000428_abnormal_craniofacial_morphol0.89804057
101MP0004142_abnormal_muscle_tone0.89087404
102MP0003938_abnormal_ear_development0.87226957
103MP0003283_abnormal_digestive_organ0.85695661
104MP0002089_abnormal_postnatal_growth/wei0.85454752
105MP0003631_nervous_system_phenotype0.84083034
106MP0003937_abnormal_limbs/digits/tail_de0.83875179
107MP0000026_abnormal_inner_ear0.83852610
108MP0009672_abnormal_birth_weight0.83693047
109MP0008961_abnormal_basal_metabolism0.83247234
110MP0001963_abnormal_hearing_physiology0.82317192
111MP0001919_abnormal_reproductive_system0.81130399
112MP0008058_abnormal_DNA_repair0.78354372
113MP0004233_abnormal_muscle_weight0.77709420
114MP0002638_abnormal_pupillary_reflex0.77705583
115MP0005623_abnormal_meninges_morphology0.77703601
116MP0005248_abnormal_Harderian_gland0.76288909
117MP0010234_abnormal_vibrissa_follicle0.73579791
118MP0010386_abnormal_urinary_bladder0.72433120
119MP0002069_abnormal_eating/drinking_beha0.72045360
120MP0001145_abnormal_male_reproductive0.71482425
121MP0003137_abnormal_impulse_conducting0.71434915
122MP0005379_endocrine/exocrine_gland_phen0.70053582
123MP0002092_abnormal_eye_morphology0.68327268
124MP0008775_abnormal_heart_ventricle0.67689157
125MP0001286_abnormal_eye_development0.67452005
126MP0002736_abnormal_nociception_after0.66885831
127MP0004043_abnormal_pH_regulation0.66271105
128MP0002233_abnormal_nose_morphology0.64338926
129MP0002127_abnormal_cardiovascular_syste0.63310714
130MP0004085_abnormal_heartbeat0.62948493
131MP0002081_perinatal_lethality0.62614562
132MP0000537_abnormal_urethra_morphology0.62004105
133MP0002735_abnormal_chemical_nociception0.61923612
134MP0002082_postnatal_lethality0.61654605
135MP0010770_preweaning_lethality0.61654605
136MP0001299_abnormal_eye_distance/0.61524082
137MP0010769_abnormal_survival0.60892411
138MP0000569_abnormal_digit_pigmentation0.60134325
139MP0010768_mortality/aging0.57781807
140MP0000751_myopathy0.57061702

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.07196942
2Pendular nystagmus (HP:0012043)6.03718413
3Posterior subcapsular cataract (HP:0007787)5.79893897
4Abdominal situs inversus (HP:0003363)5.18074327
5Abnormality of abdominal situs (HP:0011620)5.18074327
6Septo-optic dysplasia (HP:0100842)5.11108003
7Reticulocytopenia (HP:0001896)4.30319588
8Abolished electroretinogram (ERG) (HP:0000550)4.28913703
9Chorioretinal atrophy (HP:0000533)4.10840346
10Visual hallucinations (HP:0002367)4.07719167
11Scotoma (HP:0000575)4.02411332
12Severe visual impairment (HP:0001141)3.79448078
13Cone-rod dystrophy (HP:0000548)3.77472870
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.75637556
15Myokymia (HP:0002411)3.68882068
16Insomnia (HP:0100785)3.59853906
17Abnormality of macular pigmentation (HP:0008002)3.53248649
18Action tremor (HP:0002345)3.53028906
19Abnormal rod and cone electroretinograms (HP:0008323)3.52483456
20Subcapsular cataract (HP:0000523)3.33023684
21Focal seizures (HP:0007359)3.26218443
22Hemiparesis (HP:0001269)3.16204371
23Anophthalmia (HP:0000528)3.15215784
24Progressive cerebellar ataxia (HP:0002073)3.14682146
25Focal motor seizures (HP:0011153)3.14681510
26Epileptic encephalopathy (HP:0200134)3.13737959
27Abnormality of cells of the erythroid lineage (HP:0012130)3.11329081
28Abnormal number of erythroid precursors (HP:0012131)3.10083886
29Absent septum pellucidum (HP:0001331)3.04596869
30Maternal diabetes (HP:0009800)3.04300826
31Abnormality of the lower motor neuron (HP:0002366)3.03293321
32Elfin facies (HP:0004428)2.89430773
33Hyperacusis (HP:0010780)2.89202084
34Supranuclear gaze palsy (HP:0000605)2.87020299
35Diplopia (HP:0000651)2.84900484
36Abnormality of binocular vision (HP:0011514)2.84900484
37Keratoconus (HP:0000563)2.84551307
38Increased corneal curvature (HP:0100692)2.84551307
39Dysdiadochokinesis (HP:0002075)2.84522275
40Congenital stationary night blindness (HP:0007642)2.78774643
41Bony spicule pigmentary retinopathy (HP:0007737)2.76744974
42Type II diabetes mellitus (HP:0005978)2.76616521
43Macrocytic anemia (HP:0001972)2.70607359
44Type II lissencephaly (HP:0007260)2.69210278
45Double outlet right ventricle (HP:0001719)2.64981913
46Congenital malformation of the right heart (HP:0011723)2.64981913
47Impulsivity (HP:0100710)2.60758834
48Ventricular fibrillation (HP:0001663)2.60200117
49Abnormality of the septum pellucidum (HP:0007375)2.59226987
50Genetic anticipation (HP:0003743)2.58326260
51Depression (HP:0000716)2.53920792
52Constricted visual fields (HP:0001133)2.53672562
53Renovascular hypertension (HP:0100817)2.50443171
54Ankle clonus (HP:0011448)2.48656739
55Overriding aorta (HP:0002623)2.48392385
56Optic nerve hypoplasia (HP:0000609)2.47034659
57Impaired smooth pursuit (HP:0007772)2.41479169
58Abnormal number of incisors (HP:0011064)2.40197120
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.38583825
60Retinal dysplasia (HP:0007973)2.38277905
61Febrile seizures (HP:0002373)2.37180967
62Gaze-evoked nystagmus (HP:0000640)2.35031049
63Decreased central vision (HP:0007663)2.34878364
64Esophageal atresia (HP:0002032)2.34222053
65Abnormality of ocular smooth pursuit (HP:0000617)2.33873182
66Concave nail (HP:0001598)2.33470323
67Macroorchidism (HP:0000053)2.31602656
68Absence seizures (HP:0002121)2.30176076
69Duplication of thumb phalanx (HP:0009942)2.30138652
70Dysmetric saccades (HP:0000641)2.29581467
71Reticulocytosis (HP:0001923)2.28139348
72Osteomalacia (HP:0002749)2.27887713
73Pointed chin (HP:0000307)2.25725882
74Sclerocornea (HP:0000647)2.25096027
75Generalized tonic-clonic seizures (HP:0002069)2.22251561
76Colon cancer (HP:0003003)2.21948905
77Truncal ataxia (HP:0002078)2.20149940
78Testicular atrophy (HP:0000029)2.20094686
79Macular degeneration (HP:0000608)2.18998978
80Abnormal mitochondria in muscle tissue (HP:0008316)2.18611745
81Abnormal social behavior (HP:0012433)2.17709422
82Impaired social interactions (HP:0000735)2.17709422
83Gait imbalance (HP:0002141)2.14971298
84Acute necrotizing encephalopathy (HP:0006965)2.14897614
85Ectopic kidney (HP:0000086)2.14813495
86Intention tremor (HP:0002080)2.14810493
87Abnormality of the labia minora (HP:0012880)2.14802229
88Hemiplegia (HP:0002301)2.14071302
89Abnormal hair whorl (HP:0010721)2.13718330
90Mutism (HP:0002300)2.12389208
91Broad-based gait (HP:0002136)2.11431191
92Limb dystonia (HP:0002451)2.11228895
93Annular pancreas (HP:0001734)2.08515091
94Neoplasm of the heart (HP:0100544)2.07909426
95Photophobia (HP:0000613)2.04964504
96Postural instability (HP:0002172)2.04134425
97Morphological abnormality of the pyramidal tract (HP:0002062)2.03943315
98Urinary bladder sphincter dysfunction (HP:0002839)2.03166930
99Abnormality of the parathyroid morphology (HP:0011766)2.02459776
100Supernumerary spleens (HP:0009799)2.02109876
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01837082
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01837082
103Poor eye contact (HP:0000817)2.01707580
104Poor suck (HP:0002033)2.01600284
105Renal duplication (HP:0000075)2.01134527
106Aqueductal stenosis (HP:0002410)2.00550242
107Flat cornea (HP:0007720)1.99855006
108Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99502177
109Scanning speech (HP:0002168)1.99238318
110Abnormality of the corticospinal tract (HP:0002492)1.99048512
111Horseshoe kidney (HP:0000085)1.98609496
112Renal Fanconi syndrome (HP:0001994)1.98086703
113Dialeptic seizures (HP:0011146)1.97861907
114Polyphagia (HP:0002591)1.97753850
115High anterior hairline (HP:0009890)1.97474273
116Sleep apnea (HP:0010535)1.96990933
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96957945
118Obsessive-compulsive behavior (HP:0000722)1.96406627
119Partial duplication of thumb phalanx (HP:0009944)1.95423305
120Amblyopia (HP:0000646)1.95274695
121Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.94889809
122Broad distal phalanx of finger (HP:0009836)1.94820330
123Pallor (HP:0000980)1.94767428
124Optic nerve coloboma (HP:0000588)1.94740617
125Excessive salivation (HP:0003781)1.94350609
126Drooling (HP:0002307)1.94350609
127Mitochondrial inheritance (HP:0001427)1.94257336
128Dysmetria (HP:0001310)1.93953844
129Anterior segment dysgenesis (HP:0007700)1.92229791
130Hepatocellular necrosis (HP:0001404)1.91958342
131Spastic gait (HP:0002064)1.90209179
132Abnormality of the aortic arch (HP:0012303)1.88788887
133Postural tremor (HP:0002174)1.88563305
134Facial cleft (HP:0002006)1.88212424
135Abnormal gallbladder physiology (HP:0012438)1.88073585
136Cholecystitis (HP:0001082)1.88073585
137Lissencephaly (HP:0001339)1.87463191
138Autism (HP:0000717)1.86671419
139Truncus arteriosus (HP:0001660)1.86193957
140Acute encephalopathy (HP:0006846)1.86169895
141Abnormal ventriculo-arterial connection (HP:0011563)1.84879070
142Transposition of the great arteries (HP:0001669)1.84879070
143Abnormal connection of the cardiac segments (HP:0011545)1.84879070
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84256144
145Hypoplasia of the brainstem (HP:0002365)1.84256144
146Amyotrophic lateral sclerosis (HP:0007354)1.82706458
147Impaired vibration sensation in the lower limbs (HP:0002166)1.82018047
148Increased hepatocellular lipid droplets (HP:0006565)1.79396354
149Prolonged QT interval (HP:0001657)1.77109144
150Apathy (HP:0000741)1.76864509
151Septate vagina (HP:0001153)1.76443464
152Increased CSF lactate (HP:0002490)1.74718147
153Aplasia/Hypoplasia of the macula (HP:0008059)1.73977902
154Patellar aplasia (HP:0006443)1.73482296
155Hepatoblastoma (HP:0002884)1.72978763
156Absent thumb (HP:0009777)1.72526966
157Intestinal atresia (HP:0011100)1.72272712
158Abnormality of the diencephalon (HP:0010662)1.71367379
159Polar cataract (HP:0010696)1.71118780
160Renal dysplasia (HP:0000110)1.70570307
161Specific learning disability (HP:0001328)1.70337646
162Birth length less than 3rd percentile (HP:0003561)1.69481015
163Cortical dysplasia (HP:0002539)1.69439868
164Absent radius (HP:0003974)1.68892593
165Bilateral microphthalmos (HP:0007633)1.68891595
166Vaginal atresia (HP:0000148)1.68131112
167Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.67031653
168Turricephaly (HP:0000262)1.67019739
169Agitation (HP:0000713)1.66591580
170Abnormal urine phosphate concentration (HP:0012599)1.66125533
171Hepatic necrosis (HP:0002605)1.66070074
172Hyperthyroidism (HP:0000836)1.66030337
173Aplasia/Hypoplasia of the patella (HP:0006498)1.65604096
174Partial duplication of the phalanx of hand (HP:0009999)1.64882407
175Absent forearm bone (HP:0003953)1.61623794
176Aplasia involving forearm bones (HP:0009822)1.61623794
177Aplasia/Hypoplasia affecting the retina (HP:0008061)1.60637358
178Congenital primary aphakia (HP:0007707)1.60547520
179Absent/shortened dynein arms (HP:0200106)1.57929442
180Dynein arm defect of respiratory motile cilia (HP:0012255)1.57929442
181Bicornuate uterus (HP:0000813)1.57792896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.85600293
2MAP3K93.61384594
3MARK13.40219652
4DYRK23.18436107
5NTRK32.91663060
6VRK22.78430352
7PKN22.68396988
8PAK62.38817413
9MAP3K42.38224004
10SIK22.32434714
11NTRK22.21073924
12MINK12.13204706
13TAF12.09756773
14ARAF2.02629050
15KSR12.02190033
16EPHA42.01014766
17ZAK1.93768959
18KSR21.89273703
19CDC71.87438956
20DAPK21.86012233
21CAMKK11.80238803
22TYRO31.68356419
23RIPK11.67283452
24WNK41.66586954
25SMG11.64590302
26NME21.63446180
27SGK2231.61652906
28SGK4941.61652906
29PRKD31.61239874
30KDR1.59034164
31ICK1.55322272
32NEK11.55285721
33BRAF1.54575722
34AURKA1.46784471
35RET1.45432643
36STK161.38441066
37MAP2K41.36238082
38VRK11.34893213
39WNK11.33750387
40CSNK1G31.32827297
41MAP2K71.32199067
42PRPF4B1.31168145
43TRIB31.30549323
44CAMK1G1.30506472
45CDK191.29798225
46MAP3K101.28073916
47CDK51.28045585
48UHMK11.27934321
49TLK11.25307406
50PNCK1.24278884
51CHEK21.23223981
52DYRK1A1.22214845
53TAOK11.21382442
54ERBB31.20170340
55PHKG21.15414392
56PHKG11.15414392
57CAMKK21.15287991
58ALK1.15260988
59CDC42BPA1.10634251
60STK381.10377443
61CSNK1G11.09864485
62NME11.08477305
63EPHB21.04110107
64FGFR21.03918890
65STK111.02652944
66FGFR11.01020726
67DYRK30.99727234
68NTRK10.98041316
69SCYL20.98033162
70SGK30.97343471
71BUB10.95662669
72MAPK130.95442207
73NUAK10.93677934
74DYRK1B0.92630771
75ERBB20.92107685
76CDK150.91970324
77HIPK20.89810004
78IRAK20.89456067
79PRKCH0.88873266
80NEK20.88110806
81CDK180.87981372
82TNIK0.85598093
83CDK11A0.83834288
84MAP3K20.83649365
85SGK20.83646042
86RIPK40.82692273
87CDK140.82469557
88SGK10.80822982
89RPS6KA50.79684932
90PRKCG0.78202677
91EEF2K0.77470951
92TTK0.76349380
93PRKCI0.76237052
94MARK20.70306411
95CSNK1G20.69484486
96CDK70.68965025
97ATR0.67915342
98MAP3K110.65954470
99STK40.65916592
100CAMK1D0.64167047
101CAMK10.63407902
102RPS6KA30.63116784
103MAPK150.61592454
104BRD40.61528316
105MAPK90.61142857
106PAK30.60351143
107GRK50.59491632
108PKN10.59312923
109CHEK10.59085998
110MAPK100.58804740
111DAPK30.58718619
112CAMK40.58245818
113MAPKAPK50.58072103
114PRKCZ0.57896128
115GSK3B0.57548673
116PIM20.57114740
117RPS6KA60.56109372
118CDK20.56108599
119WNK30.55791579
120RPS6KL10.55425777
121RPS6KC10.55425777
122PLK10.55092052
123PRKAA10.54179387
124SIK10.53748780
125MAPK80.50596979
126RPS6KA20.50371008
127ABL20.49420925
128CAMK2A0.49104862
129PRKD10.48318758
130CSNK1A1L0.48151286
131MTOR0.47716611
132ILK0.47637893
133SRPK10.47403777
134CSNK1E0.47388098
135FYN0.46988290
136PINK10.46486258
137DAPK10.45614617
138CDK30.45576328
139BRSK10.45529721
140MAPK140.44591888
141PRKCB0.44334707
142CDK10.43844046
143PASK0.43570767
144MAPK120.42783886
145CSNK2A20.41940785
146PTK60.41475881
147MAP3K130.41067036
148PRKDC0.40392203
149PDGFRA0.39551591
150TAOK20.39000819

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.17642769
2Sulfur relay system_Homo sapiens_hsa041223.31663537
3Synaptic vesicle cycle_Homo sapiens_hsa047213.19654554
4Oxidative phosphorylation_Homo sapiens_hsa001903.15577314
5Nicotine addiction_Homo sapiens_hsa050333.02496333
6Parkinsons disease_Homo sapiens_hsa050122.91379522
7Circadian entrainment_Homo sapiens_hsa047132.88197561
8GABAergic synapse_Homo sapiens_hsa047272.86082636
9Glutamatergic synapse_Homo sapiens_hsa047242.51210093
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44570750
11Morphine addiction_Homo sapiens_hsa050322.42850773
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39067130
13Long-term potentiation_Homo sapiens_hsa047202.24897953
14Huntingtons disease_Homo sapiens_hsa050162.19776126
15DNA replication_Homo sapiens_hsa030302.03118472
16Dopaminergic synapse_Homo sapiens_hsa047282.02709862
17Cholinergic synapse_Homo sapiens_hsa047252.00968091
18Alzheimers disease_Homo sapiens_hsa050102.00694561
19Olfactory transduction_Homo sapiens_hsa047402.00094106
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.96563864
21RNA polymerase_Homo sapiens_hsa030201.80236422
22Amphetamine addiction_Homo sapiens_hsa050311.78292827
23Insulin secretion_Homo sapiens_hsa049111.75982438
24Salivary secretion_Homo sapiens_hsa049701.67689383
25Mismatch repair_Homo sapiens_hsa034301.67373555
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57715342
27Type II diabetes mellitus_Homo sapiens_hsa049301.50570366
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50503135
29Gastric acid secretion_Homo sapiens_hsa049711.48532228
30Oxytocin signaling pathway_Homo sapiens_hsa049211.47540718
31Homologous recombination_Homo sapiens_hsa034401.46946080
32Long-term depression_Homo sapiens_hsa047301.46550158
33mTOR signaling pathway_Homo sapiens_hsa041501.44396561
34Cocaine addiction_Homo sapiens_hsa050301.42520541
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42090862
36Phototransduction_Homo sapiens_hsa047441.37775449
37Renin secretion_Homo sapiens_hsa049241.37624887
38Base excision repair_Homo sapiens_hsa034101.35352980
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35177777
40Serotonergic synapse_Homo sapiens_hsa047261.33722148
41Taste transduction_Homo sapiens_hsa047421.31917444
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30572485
43Phenylalanine metabolism_Homo sapiens_hsa003601.28456575
44Gap junction_Homo sapiens_hsa045401.27965226
45Renal cell carcinoma_Homo sapiens_hsa052111.26359288
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26200682
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26154585
48Basal cell carcinoma_Homo sapiens_hsa052171.25852663
49Pyrimidine metabolism_Homo sapiens_hsa002401.25722716
50GnRH signaling pathway_Homo sapiens_hsa049121.22874744
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21969657
52Glioma_Homo sapiens_hsa052141.21611346
53Calcium signaling pathway_Homo sapiens_hsa040201.20958167
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.20893882
55Vitamin B6 metabolism_Homo sapiens_hsa007501.18633380
56Spliceosome_Homo sapiens_hsa030401.18020476
57Estrogen signaling pathway_Homo sapiens_hsa049151.14859309
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12963762
59* Axon guidance_Homo sapiens_hsa043601.12617240
60cAMP signaling pathway_Homo sapiens_hsa040241.11882442
61RNA transport_Homo sapiens_hsa030131.11844876
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08368419
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07984093
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05952688
65Non-small cell lung cancer_Homo sapiens_hsa052231.04367580
66Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00439737
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99997507
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.98794462
69ErbB signaling pathway_Homo sapiens_hsa040120.96931726
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96147030
71Endometrial cancer_Homo sapiens_hsa052130.96130308
72Purine metabolism_Homo sapiens_hsa002300.94902623
73Fanconi anemia pathway_Homo sapiens_hsa034600.93408297
74Alcoholism_Homo sapiens_hsa050340.93167321
75Circadian rhythm_Homo sapiens_hsa047100.93105066
76Basal transcription factors_Homo sapiens_hsa030220.92016532
77Glucagon signaling pathway_Homo sapiens_hsa049220.89322975
78Oocyte meiosis_Homo sapiens_hsa041140.88967936
79One carbon pool by folate_Homo sapiens_hsa006700.86945340
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85398410
81MAPK signaling pathway_Homo sapiens_hsa040100.83762513
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.83124512
83Bile secretion_Homo sapiens_hsa049760.82545499
84VEGF signaling pathway_Homo sapiens_hsa043700.82504758
85Arginine and proline metabolism_Homo sapiens_hsa003300.82030982
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.81735211
87Dorso-ventral axis formation_Homo sapiens_hsa043200.80760192
88Cell cycle_Homo sapiens_hsa041100.80549109
89Choline metabolism in cancer_Homo sapiens_hsa052310.79092370
90Ovarian steroidogenesis_Homo sapiens_hsa049130.77787614
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76421466
92Folate biosynthesis_Homo sapiens_hsa007900.75140850
93Melanogenesis_Homo sapiens_hsa049160.75107214
94Notch signaling pathway_Homo sapiens_hsa043300.74145047
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73015209
96Fatty acid elongation_Homo sapiens_hsa000620.71639065
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71223142
98Dilated cardiomyopathy_Homo sapiens_hsa054140.71214862
99Thyroid hormone synthesis_Homo sapiens_hsa049180.70180848
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70148337
101Cardiac muscle contraction_Homo sapiens_hsa042600.69770237
102Lysine degradation_Homo sapiens_hsa003100.69562574
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.69495444
104HIF-1 signaling pathway_Homo sapiens_hsa040660.69450004
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68925438
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.68126013
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67308623
108Inositol phosphate metabolism_Homo sapiens_hsa005620.66994384
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63847773
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63273340
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62955479
112Nucleotide excision repair_Homo sapiens_hsa034200.62540058
113Pancreatic secretion_Homo sapiens_hsa049720.61845826
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61807360
115mRNA surveillance pathway_Homo sapiens_hsa030150.61167187
116Nitrogen metabolism_Homo sapiens_hsa009100.60430793
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60070556
118Colorectal cancer_Homo sapiens_hsa052100.59798801
119Chronic myeloid leukemia_Homo sapiens_hsa052200.58021537
120Insulin signaling pathway_Homo sapiens_hsa049100.57339625
121Steroid biosynthesis_Homo sapiens_hsa001000.55577832
122RNA degradation_Homo sapiens_hsa030180.55470411
123Thyroid cancer_Homo sapiens_hsa052160.53531349
124Metabolic pathways_Homo sapiens_hsa011000.51867950
125Collecting duct acid secretion_Homo sapiens_hsa049660.51497338
126Ras signaling pathway_Homo sapiens_hsa040140.51296628
127AMPK signaling pathway_Homo sapiens_hsa041520.51011144
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50783489
129Systemic lupus erythematosus_Homo sapiens_hsa053220.48892952
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45531955
131Bladder cancer_Homo sapiens_hsa052190.44850804
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43806330
133Protein export_Homo sapiens_hsa030600.43703183
134Rap1 signaling pathway_Homo sapiens_hsa040150.42369717
135Biosynthesis of amino acids_Homo sapiens_hsa012300.41901993
136Wnt signaling pathway_Homo sapiens_hsa043100.41881508
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41701765
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41546924
139Regulation of autophagy_Homo sapiens_hsa041400.40916694
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40878740
141Pancreatic cancer_Homo sapiens_hsa052120.40551090
142Hedgehog signaling pathway_Homo sapiens_hsa043400.39437233
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39193797
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39088530
145Chemokine signaling pathway_Homo sapiens_hsa040620.38977160
146Endocytosis_Homo sapiens_hsa041440.38890579
147Insulin resistance_Homo sapiens_hsa049310.38500741
148Hippo signaling pathway_Homo sapiens_hsa043900.37811214
149Melanoma_Homo sapiens_hsa052180.35458713

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