EPHB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron projection extension involved in neuron projection guidance (GO:1902284)4.96557432
2axon extension involved in axon guidance (GO:0048846)4.96557432
3lateral sprouting from an epithelium (GO:0060601)4.65483538
4establishment of tissue polarity (GO:0007164)4.60934496
5establishment of planar polarity (GO:0001736)4.60934496
6pyrimidine nucleobase catabolic process (GO:0006208)4.60315004
7limb bud formation (GO:0060174)4.48443616
8negative regulation of axon guidance (GO:1902668)4.47310253
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44874416
10lung epithelium development (GO:0060428)4.41471542
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.31880915
12ganglion development (GO:0061548)4.03989093
13presynaptic membrane assembly (GO:0097105)3.96565464
14cell migration in hindbrain (GO:0021535)3.94149024
15layer formation in cerebral cortex (GO:0021819)3.91956634
16* axonal fasciculation (GO:0007413)3.91440860
17neuronal stem cell maintenance (GO:0097150)3.86814556
18response to pheromone (GO:0019236)3.86149526
19establishment of nucleus localization (GO:0040023)3.83569590
20G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.82595781
21presynaptic membrane organization (GO:0097090)3.82480580
22postsynaptic membrane organization (GO:0001941)3.78924245
23negative regulation of axon extension involved in axon guidance (GO:0048843)3.77505440
24negative regulation of oligodendrocyte differentiation (GO:0048715)3.76666291
25* central nervous system projection neuron axonogenesis (GO:0021952)3.75577011
26embryonic foregut morphogenesis (GO:0048617)3.71638791
27negative regulation of catenin import into nucleus (GO:0035414)3.60491353
28sequestering of actin monomers (GO:0042989)3.57616591
29regulation of axon guidance (GO:1902667)3.48734333
30dopaminergic neuron differentiation (GO:0071542)3.43688711
31negative chemotaxis (GO:0050919)3.39506099
32neuron fate determination (GO:0048664)3.39338152
33* neuron recognition (GO:0008038)3.38113517
34nucleobase catabolic process (GO:0046113)3.36679119
35positive regulation of gastrulation (GO:2000543)3.34197825
36dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.32193570
37negative regulation of axon extension (GO:0030517)3.30607890
38axon extension (GO:0048675)3.27196246
39paraxial mesoderm development (GO:0048339)3.26887923
40regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.20259817
41cell proliferation involved in metanephros development (GO:0072203)3.19861138
42chondrocyte development (GO:0002063)3.19823090
43astrocyte differentiation (GO:0048708)3.13661110
44regulation of mesenchymal cell apoptotic process (GO:2001053)3.11889025
45lung-associated mesenchyme development (GO:0060484)3.10577467
46cochlea morphogenesis (GO:0090103)3.09283565
47Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.09167647
48innervation (GO:0060384)3.07967118
49midbrain development (GO:0030901)3.07568982
50behavioral response to nicotine (GO:0035095)3.07433983
51regulation of establishment of planar polarity (GO:0090175)3.07158853
52renal system development (GO:0072001)3.05368796
53glomerulus development (GO:0032835)3.03923728
54negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.00063697
55apical protein localization (GO:0045176)2.99988332
56face development (GO:0060324)2.98245125
57epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.98045084
58lens fiber cell development (GO:0070307)2.97243674
59pattern specification involved in kidney development (GO:0061004)2.95368829
60regulation of axon extension involved in axon guidance (GO:0048841)2.93707989
61cerebral cortex radially oriented cell migration (GO:0021799)2.93007591
62neuron cell-cell adhesion (GO:0007158)2.91253560
63* retinal ganglion cell axon guidance (GO:0031290)2.90801237
64embryonic hindlimb morphogenesis (GO:0035116)2.90438693
65negative regulation of embryonic development (GO:0045992)2.89035877
66hindbrain development (GO:0030902)2.88911098
67dendrite morphogenesis (GO:0048813)2.87919340
68myotube differentiation (GO:0014902)2.87595152
69establishment of monopolar cell polarity (GO:0061162)2.85428943
70establishment or maintenance of monopolar cell polarity (GO:0061339)2.85428943
71gastrulation with mouth forming second (GO:0001702)2.84865294
72regulation of oligodendrocyte differentiation (GO:0048713)2.84800390
73cellular response to cholesterol (GO:0071397)2.83451713
74artery development (GO:0060840)2.83314555
75* positive regulation of synapse assembly (GO:0051965)2.83251838
76head development (GO:0060322)2.81047360
77negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.80307000
78substrate-dependent cell migration (GO:0006929)2.78727928
79* central nervous system neuron axonogenesis (GO:0021955)2.78677833
80embryonic skeletal system development (GO:0048706)2.78386995
81neuron migration (GO:0001764)2.77751850
82auditory behavior (GO:0031223)2.76896797
83neuron projection extension (GO:1990138)2.76874397
84positive regulation of synapse maturation (GO:0090129)2.75964083
85regulation of neuron migration (GO:2001222)2.75291213
86hindlimb morphogenesis (GO:0035137)2.75267217
87glomerular filtration (GO:0003094)2.74939596
88convergent extension (GO:0060026)2.73881899
89substrate-independent telencephalic tangential migration (GO:0021826)2.73035162
90substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73035162
91positive regulation of neuroblast proliferation (GO:0002052)2.72650354
92mesenchymal cell proliferation (GO:0010463)2.72570417
93forebrain neuron differentiation (GO:0021879)2.72289529
94response to auditory stimulus (GO:0010996)2.71470065
95calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70614991
96olfactory bulb development (GO:0021772)2.70323534
97regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.70260779
98hippo signaling (GO:0035329)2.70018350
99somite development (GO:0061053)2.69845640
100atrial cardiac muscle cell action potential (GO:0086014)2.69585699
101negative regulation of chondrocyte differentiation (GO:0032331)2.69416082
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69323122
103vocalization behavior (GO:0071625)2.69029748
104positive regulation of embryonic development (GO:0040019)2.68440944
105nucleosome disassembly (GO:0006337)2.67802760
106protein-DNA complex disassembly (GO:0032986)2.67802760
107cell-cell junction maintenance (GO:0045217)2.67273406
108asymmetric protein localization (GO:0008105)2.66278009
109neuroblast proliferation (GO:0007405)2.65904987
110branching involved in salivary gland morphogenesis (GO:0060445)2.65727247
111spinal cord development (GO:0021510)2.65715731
112positive regulation of oligodendrocyte differentiation (GO:0048714)2.64689920
113cell proliferation in forebrain (GO:0021846)2.63195076
114post-anal tail morphogenesis (GO:0036342)2.62605564
115regulation of axon extension (GO:0030516)2.61953662
116lung lobe morphogenesis (GO:0060463)2.61224035
117kidney morphogenesis (GO:0060993)2.60729490
118non-canonical Wnt signaling pathway (GO:0035567)2.60573771
119establishment of apical/basal cell polarity (GO:0035089)2.59613409
120chondrocyte proliferation (GO:0035988)2.59524399
121positive regulation of smoothened signaling pathway (GO:0045880)2.59308674
122establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59192004
123glomerular basement membrane development (GO:0032836)2.58465089
124cerebral cortex cell migration (GO:0021795)2.58290806
125dendrite development (GO:0016358)2.57936823
126developmental cell growth (GO:0048588)2.56782032
127regulation of chemokine-mediated signaling pathway (GO:0070099)2.56139293
128mesenchyme morphogenesis (GO:0072132)2.54758259
129inner ear receptor cell development (GO:0060119)2.54532873
130* dendritic spine morphogenesis (GO:0060997)2.53731056
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52764378
132glial cell proliferation (GO:0014009)2.52593378
133mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.52537640
134cell adhesion mediated by integrin (GO:0033627)2.51203647
135glial cell migration (GO:0008347)2.51170213
136nucleus localization (GO:0051647)2.50790054
137thalamus development (GO:0021794)2.50347442
138semaphorin-plexin signaling pathway (GO:0071526)2.49769702
139epithelial tube branching involved in lung morphogenesis (GO:0060441)2.48878866
140neural precursor cell proliferation (GO:0061351)2.47343911
141synapse assembly (GO:0007416)2.46698622
142primitive streak formation (GO:0090009)2.46569775
143establishment of mitochondrion localization (GO:0051654)2.44981802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18890005
2EZH2_27304074_Chip-Seq_ESCs_Mouse3.31234079
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.21190664
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.09070077
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.95466082
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.95466082
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78694586
8PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.77777683
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71695951
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71512540
11RNF2_27304074_Chip-Seq_ESCs_Mouse2.62860199
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59448073
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.50829941
14RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.50522245
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.48205911
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.40945846
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39694476
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30790497
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29303757
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28704946
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28350800
22GBX2_23144817_ChIP-Seq_PC3_Human2.27847604
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23615772
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.20597406
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05688151
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01378002
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.96772887
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95194439
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95040303
30RING1B_27294783_Chip-Seq_NPCs_Mouse1.90300930
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86564411
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84636347
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82169188
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.80508740
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74763437
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71673145
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68334852
38* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.66301048
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63259341
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.60400654
41RNF2_27304074_Chip-Seq_NSC_Mouse1.58665186
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.56970298
43* DROSHA_22980978_ChIP-Seq_HELA_Human1.56634386
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51856078
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50855738
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50587975
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45068596
48* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42669078
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41708898
50* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40346784
51REST_21632747_ChIP-Seq_MESCs_Mouse1.39373269
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.39001734
53SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36656634
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.34480555
55IGF1R_20145208_ChIP-Seq_DFB_Human1.33908804
56ZNF274_21170338_ChIP-Seq_K562_Hela1.33868530
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.33269238
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.33145876
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.29060473
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28534967
61AR_21572438_ChIP-Seq_LNCaP_Human1.25371910
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24520666
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.21528448
64* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19027791
65* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18134624
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17580109
67* TP53_18474530_ChIP-ChIP_U2OS_Human1.16870703
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14646889
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12859499
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12072423
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.11026338
72* KDM2B_26808549_Chip-Seq_K562_Human1.10925386
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09749847
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.09719720
75AHR_22903824_ChIP-Seq_MCF-7_Human1.09350873
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08516044
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07892287
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07892287
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.07856216
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.07341387
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07169802
82POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06628105
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.06130066
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05139321
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04497231
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.03887825
87* AR_19668381_ChIP-Seq_PC3_Human1.03827963
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03445599
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.02901727
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.02769776
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00803242
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00314356
93CJUN_26792858_Chip-Seq_BT549_Human1.00037992
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99193738
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99061864
96P300_19829295_ChIP-Seq_ESCs_Human0.98905020
97TBX3_20139965_ChIP-Seq_MESCs_Mouse0.97438830
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96746699
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.96345026
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95968534
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95502285
102FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94924310
103SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94791274
104TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94622837
105NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92782761
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92069424
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.91722729
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91097753
109TP53_16413492_ChIP-PET_HCT116_Human0.90431775
110AR_25329375_ChIP-Seq_VCAP_Human0.90021669
111RARB_27405468_Chip-Seq_BRAIN_Mouse0.89901500
112* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89351349
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89076833
114SMAD4_21799915_ChIP-Seq_A2780_Human0.88342766
115SOX3_22085726_ChIP-Seq_NPCs_Mouse0.88210504
116* SOX2_21211035_ChIP-Seq_LN229_Gbm0.86654888
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85975192
118POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.84475164
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84161564
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82827118
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82340965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.29416973
2MP0010030_abnormal_orbit_morphology3.24614178
3MP0003283_abnormal_digestive_organ3.15906315
4MP0000566_synostosis3.02081894
5* MP0000778_abnormal_nervous_system2.90271193
6MP0002102_abnormal_ear_morphology2.85782126
7MP0009053_abnormal_anal_canal2.71848943
8MP0003122_maternal_imprinting2.71728189
9MP0002234_abnormal_pharynx_morphology2.26244019
10MP0000049_abnormal_middle_ear2.13765835
11MP0003938_abnormal_ear_development2.01636779
12MP0003136_yellow_coat_color1.99689105
13MP0002249_abnormal_larynx_morphology1.98533135
14MP0002653_abnormal_ependyma_morphology1.94931331
15MP0002282_abnormal_trachea_morphology1.94490074
16MP0004859_abnormal_synaptic_plasticity1.93761985
17MP0003121_genomic_imprinting1.91512756
18* MP0000537_abnormal_urethra_morphology1.90804525
19MP0008789_abnormal_olfactory_epithelium1.89632791
20MP0003385_abnormal_body_wall1.89532049
21MP0003880_abnormal_central_pattern1.83903060
22MP0003119_abnormal_digestive_system1.79466772
23MP0002751_abnormal_autonomic_nervous1.75819798
24MP0004133_heterotaxia1.72928265
25MP0003937_abnormal_limbs/digits/tail_de1.71642667
26MP0003942_abnormal_urinary_system1.71338597
27MP0000462_abnormal_digestive_system1.70676745
28* MP0003861_abnormal_nervous_system1.67427974
29MP0000569_abnormal_digit_pigmentation1.67344789
30MP0003115_abnormal_respiratory_system1.65831665
31MP0002233_abnormal_nose_morphology1.64576247
32MP0005423_abnormal_somatic_nervous1.61328455
33MP0005503_abnormal_tendon_morphology1.60282214
34MP0003755_abnormal_palate_morphology1.59766101
35MP0002822_catalepsy1.57887913
36MP0005248_abnormal_Harderian_gland1.57185668
37MP0002116_abnormal_craniofacial_bone1.56346769
38MP0002932_abnormal_joint_morphology1.55580172
39MP0000631_abnormal_neuroendocrine_gland1.54903785
40MP0006292_abnormal_olfactory_placode1.54692547
41MP0005394_taste/olfaction_phenotype1.52755402
42MP0005499_abnormal_olfactory_system1.52755402
43MP0009250_abnormal_appendicular_skeleto1.50840826
44* MP0002184_abnormal_innervation1.50508690
45MP0002938_white_spotting1.48161290
46MP0000467_abnormal_esophagus_morphology1.47355321
47MP0005257_abnormal_intraocular_pressure1.46423786
48MP0000428_abnormal_craniofacial_morphol1.45588897
49MP0006276_abnormal_autonomic_nervous1.45390574
50MP0001299_abnormal_eye_distance/1.42278935
51MP0005076_abnormal_cell_differentiation1.38127631
52MP0000534_abnormal_ureter_morphology1.37640356
53MP0000955_abnormal_spinal_cord1.34816321
54MP0003890_abnormal_embryonic-extraembry1.33380530
55MP0003935_abnormal_craniofacial_develop1.32632665
56MP0005197_abnormal_uvea_morphology1.31559021
57MP0001293_anophthalmia1.29737614
58MP0003635_abnormal_synaptic_transmissio1.29702556
59MP0001286_abnormal_eye_development1.28344307
60MP0005195_abnormal_posterior_eye1.27611826
61MP0002697_abnormal_eye_size1.25588503
62MP0005187_abnormal_penis_morphology1.22167562
63MP0004270_analgesia1.21572243
64* MP0002152_abnormal_brain_morphology1.19255661
65* MP0000026_abnormal_inner_ear1.19075305
66MP0002063_abnormal_learning/memory/cond1.18730027
67MP0002557_abnormal_social/conspecific_i1.17090165
68MP0000579_abnormal_nail_morphology1.16914048
69MP0003123_paternal_imprinting1.14026286
70MP0000538_abnormal_urinary_bladder1.10868149
71MP0006072_abnormal_retinal_apoptosis1.10602227
72MP0002081_perinatal_lethality1.10583837
73MP0003634_abnormal_glial_cell1.08685029
74MP0003787_abnormal_imprinting1.07191561
75MP0009780_abnormal_chondrocyte_physiolo1.06878712
76MP0000647_abnormal_sebaceous_gland1.06105433
77* MP0005391_vision/eye_phenotype1.05867510
78MP0001529_abnormal_vocalization1.05654996
79* MP0002882_abnormal_neuron_morphology1.04983419
80MP0000432_abnormal_head_morphology1.04561163
81MP0004885_abnormal_endolymph1.03388569
82MP0004272_abnormal_basement_membrane1.03096356
83MP0002089_abnormal_postnatal_growth/wei1.02648101
84MP0002111_abnormal_tail_morphology1.01371110
85MP0005508_abnormal_skeleton_morphology0.99869860
86MP0004811_abnormal_neuron_physiology0.95942389
87MP0000762_abnormal_tongue_morphology0.95752838
88MP0002734_abnormal_mechanical_nocicepti0.94958125
89MP0002085_abnormal_embryonic_tissue0.92050620
90MP0002177_abnormal_outer_ear0.91793394
91MP0002114_abnormal_axial_skeleton0.90928644
92MP0002084_abnormal_developmental_patter0.88172786
93MP0000733_abnormal_muscle_development0.87766530
94* MP0002752_abnormal_somatic_nervous0.87318715
95MP0001486_abnormal_startle_reflex0.86220045
96MP0004134_abnormal_chest_morphology0.84907754
97MP0002896_abnormal_bone_mineralization0.84319816
98MP0004197_abnormal_fetal_growth/weight/0.82496747
99MP0004858_abnormal_nervous_system0.82461469
100MP0002109_abnormal_limb_morphology0.81861177
101MP0002572_abnormal_emotion/affect_behav0.81786640
102MP0005623_abnormal_meninges_morphology0.81534376
103* MP0002092_abnormal_eye_morphology0.81223857
104MP0001188_hyperpigmentation0.80540436
105MP0003137_abnormal_impulse_conducting0.80476516
106MP0000163_abnormal_cartilage_morphology0.80431752
107MP0000516_abnormal_urinary_system0.80361209
108MP0005367_renal/urinary_system_phenotyp0.80361209
109MP0000383_abnormal_hair_follicle0.80051196
110MP0001849_ear_inflammation0.79731688
111MP0004233_abnormal_muscle_weight0.79436448
112MP0001879_abnormal_lymphatic_vessel0.78296045
113MP0008438_abnormal_cutaneous_collagen0.77630556
114MP0001970_abnormal_pain_threshold0.77412958
115MP0002735_abnormal_chemical_nociception0.76680797
116MP0005595_abnormal_vascular_smooth0.76299438
117MP0005645_abnormal_hypothalamus_physiol0.75640138
118MP0005409_darkened_coat_color0.74642340
119MP0001346_abnormal_lacrimal_gland0.74629451
120MP0002067_abnormal_sensory_capabilities0.73796529
121MP0001968_abnormal_touch/_nociception0.73483429

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.59803053
2Short 4th metacarpal (HP:0010044)3.59803053
3Renal duplication (HP:0000075)3.31553651
4Shallow orbits (HP:0000586)2.91953336
5Hyperacusis (HP:0010780)2.81166482
6Bilateral microphthalmos (HP:0007633)2.71690945
7Abnormality of the 4th metacarpal (HP:0010012)2.68049519
8Abnormal number of incisors (HP:0011064)2.63143878
9Atrophic scars (HP:0001075)2.57294165
10Elfin facies (HP:0004428)2.50897817
11Morphological abnormality of the middle ear (HP:0008609)2.50704133
12Anophthalmia (HP:0000528)2.49504660
13Renovascular hypertension (HP:0100817)2.48474851
14Overriding aorta (HP:0002623)2.46631191
15Abnormality of the labia minora (HP:0012880)2.45298140
16Aqueductal stenosis (HP:0002410)2.41457890
17Broad metatarsal (HP:0001783)2.40219211
18Septo-optic dysplasia (HP:0100842)2.34246063
19Optic nerve hypoplasia (HP:0000609)2.33182486
20Hepatoblastoma (HP:0002884)2.33036177
21Tented upper lip vermilion (HP:0010804)2.29045288
22Flat cornea (HP:0007720)2.27868558
23Coronal craniosynostosis (HP:0004440)2.27336577
24Arterial tortuosity (HP:0005116)2.25733122
25Cortical dysplasia (HP:0002539)2.21957862
26Narrow nasal bridge (HP:0000446)2.18079073
27Partial duplication of thumb phalanx (HP:0009944)2.17409680
28Partial duplication of the phalanx of hand (HP:0009999)2.15163996
29Abnormality of dentin (HP:0010299)2.14845009
30Patellar dislocation (HP:0002999)2.14223741
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.10920966
32Vertebral hypoplasia (HP:0008417)2.10920966
33Maternal diabetes (HP:0009800)2.09488266
34Growth hormone deficiency (HP:0000824)2.07252709
35Vitreoretinal degeneration (HP:0000655)2.05827578
3611 pairs of ribs (HP:0000878)2.02698780
37High anterior hairline (HP:0009890)2.00989447
38Abnormality of the distal phalanx of the thumb (HP:0009617)2.00273796
39Short nail (HP:0001799)2.00109486
40Vascular tortuosity (HP:0004948)2.00100333
41Turricephaly (HP:0000262)2.00031651
42Labial hypoplasia (HP:0000066)1.99209593
43Hemivertebrae (HP:0002937)1.99207397
44Sacral dimple (HP:0000960)1.98927767
45Midline defect of the nose (HP:0004122)1.98622780
46Missing ribs (HP:0000921)1.96526864
47Increased nuchal translucency (HP:0010880)1.96005460
48Bladder diverticulum (HP:0000015)1.95806259
49Abnormality of the antihelix (HP:0009738)1.94917603
50Aplasia involving bones of the upper limbs (HP:0009823)1.94372271
51Aplasia of the phalanges of the hand (HP:0009802)1.94372271
52Aplasia involving bones of the extremities (HP:0009825)1.94372271
53Oligodactyly (hands) (HP:0001180)1.93737706
54Shawl scrotum (HP:0000049)1.93604089
55Abnormality of the diencephalon (HP:0010662)1.93017513
56Insomnia (HP:0100785)1.91671652
57Intestinal atresia (HP:0011100)1.91147155
58Hypoplasia of the brainstem (HP:0002365)1.90987456
59Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90987456
60Cutaneous finger syndactyly (HP:0010554)1.90049621
61Oligodactyly (HP:0012165)1.88738724
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88663250
63Exotropia (HP:0000577)1.87991753
64Megalocornea (HP:0000485)1.87293370
65Pointed chin (HP:0000307)1.86726307
66Gastrointestinal atresia (HP:0002589)1.85047134
67Broad face (HP:0000283)1.84690133
68Neonatal short-limb short stature (HP:0008921)1.84360771
69Deviation of the hallux (HP:0010051)1.83673989
70Bowel diverticulosis (HP:0005222)1.83643071
71Hypoplastic female external genitalia (HP:0012815)1.83269007
72Synostosis of carpal bones (HP:0005048)1.82479349
73Increased number of teeth (HP:0011069)1.82110537
74Tibial bowing (HP:0002982)1.82036384
75Wrist flexion contracture (HP:0001239)1.82021071
76Short philtrum (HP:0000322)1.81625408
77Esophageal atresia (HP:0002032)1.81314605
78Astrocytoma (HP:0009592)1.81058734
79Abnormality of the astrocytes (HP:0100707)1.81058734
80Abnormality of chromosome segregation (HP:0002916)1.80360538
81Chin dimple (HP:0010751)1.80170548
82Wide anterior fontanel (HP:0000260)1.79799998
83Myokymia (HP:0002411)1.79432739
84Obsessive-compulsive behavior (HP:0000722)1.79290110
85Hallux valgus (HP:0001822)1.78922886
86Trigonocephaly (HP:0000243)1.78788036
87Fibular hypoplasia (HP:0003038)1.76900746
88Neurofibrillary tangles (HP:0002185)1.76872517
89Shoulder girdle muscle weakness (HP:0003547)1.76662769
90Large earlobe (HP:0009748)1.75470029
91Abnormality of the aortic arch (HP:0012303)1.74829990
92Vesicoureteral reflux (HP:0000076)1.74263070
93Anterior segment dysgenesis (HP:0007700)1.74164995
94Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73900794
95Leiomyosarcoma (HP:0100243)1.73772348
96Uterine leiomyosarcoma (HP:0002891)1.73772348
97Genu recurvatum (HP:0002816)1.73365007
98Nuclear cataract (HP:0100018)1.72966135
99Retinal dysplasia (HP:0007973)1.72462650
100Megalencephaly (HP:0001355)1.72077554
101Wide cranial sutures (HP:0010537)1.71792350
102Drooling (HP:0002307)1.70567256
103Protrusio acetabuli (HP:0003179)1.69492023
104Hypoplastic pelvis (HP:0008839)1.68970165
105Polyphagia (HP:0002591)1.68456416
106Concave nail (HP:0001598)1.67933812
107Abnormality of the parietal bone (HP:0002696)1.67654814
108Hypoventilation (HP:0002791)1.67276395
109Meningocele (HP:0002435)1.67229918
110Down-sloping shoulders (HP:0200021)1.67153109
111Cutaneous syndactyly (HP:0012725)1.66915938
112Preaxial foot polydactyly (HP:0001841)1.66690058
113Bronchomalacia (HP:0002780)1.66341847
114Rib fusion (HP:0000902)1.66064773
115Abnormality of the right ventricle (HP:0001707)1.65950744
116Spina bifida occulta (HP:0003298)1.65418024
117Mixed hearing impairment (HP:0000410)1.64799647
118Hypoplastic labia majora (HP:0000059)1.64045440
119Mesomelia (HP:0003027)1.63705305
120Broad finger (HP:0001500)1.62884350
121Chorioretinal atrophy (HP:0000533)1.61920906
122Absent septum pellucidum (HP:0001331)1.61104375
123Focal seizures (HP:0007359)1.60360195
124Abnormality of abdominal situs (HP:0011620)1.60035878
125Abdominal situs inversus (HP:0003363)1.60035878
126Overgrowth (HP:0001548)1.59578731
127Lissencephaly (HP:0001339)1.59574684
128Arnold-Chiari malformation (HP:0002308)1.59538619
129Abnormality of the incisor (HP:0000676)1.58823223
130Abnormality of the intervertebral disk (HP:0005108)1.58419461
131Vertebral arch anomaly (HP:0008438)1.57520886
132Vertebral clefting (HP:0008428)1.57406156
133Renal hypoplasia (HP:0000089)1.57199653
134Focal motor seizures (HP:0011153)1.57168348
135Pachygyria (HP:0001302)1.57159387
136Aplasia/Hypoplasia of the fibula (HP:0006492)1.57032361
137Limb dystonia (HP:0002451)1.56399348
138Autism (HP:0000717)1.55022757
139Abnormality of the labia majora (HP:0012881)1.55003223
140Transitional cell carcinoma of the bladder (HP:0006740)1.54577166
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.54339180
142Buphthalmos (HP:0000557)1.54105920
143Hyperthyroidism (HP:0000836)1.53585524
144Irregular vertebral endplates (HP:0003301)1.53404435
145Glioma (HP:0009733)1.52939815
146Abnormality of the ischium (HP:0003174)1.52565515
147Limited hip movement (HP:0008800)1.52474601
148Fragile skin (HP:0001030)1.52457111
149Aplasia/Hypoplasia of the sternum (HP:0006714)1.51818937
150Premature rupture of membranes (HP:0001788)1.51347743
151Truncus arteriosus (HP:0001660)1.50809323
152Germ cell neoplasia (HP:0100728)1.50522631
153Ankyloglossia (HP:0010296)1.50141947
154Telecanthus (HP:0000506)1.49805990
155Aplasia/Hypoplasia of the clavicles (HP:0006710)1.49241680
156Abnormality of the labia (HP:0000058)1.49183878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.44559911
2SIK34.03295200
3BCR2.96428047
4NTRK22.54271076
5DYRK22.32132489
6ERBB32.25896294
7MAP3K102.22714513
8* KSR12.20387717
9MINK12.02047173
10MAPK131.99896973
11* EPHB21.98978650
12EPHA21.92301463
13UHMK11.92047670
14NTRK31.85752321
15ICK1.75167807
16LATS21.62979925
17SIK21.60957373
18MET1.47936372
19PASK1.47310461
20PAK61.44199698
21MAP3K41.37985864
22MST1R1.37793921
23PTK21.33028663
24CASK1.31085280
25DDR21.30971088
26WNK31.30903341
27SRPK11.30420828
28* ERBB21.26261441
29MKNK11.25854277
30CDK181.23103672
31FGFR21.21400568
32CDK191.16833850
33ADRBK21.14010415
34CDC71.13052639
35NTRK11.12155913
36TLK11.11226861
37PNCK1.10146604
38SIK11.05227903
39CAMK1G1.04944116
40CDK151.01765458
41DYRK31.01045390
42MKNK20.97486133
43TNIK0.96907991
44PRPF4B0.96691925
45CDK11A0.96629727
46CDK140.95867146
47TAF10.95437997
48WEE10.92489106
49CDK80.92375337
50CAMK1D0.92327768
51ROCK20.90605302
52LATS10.90302046
53PDGFRA0.90134196
54LIMK10.89815649
55PAK30.89004388
56PAK40.88972711
57DYRK1A0.87875226
58NEK20.87792977
59CSNK1A1L0.87442002
60MAP3K90.86580077
61MAP2K70.86508101
62IRAK20.85423953
63BRD40.85405689
64TGFBR20.84032489
65MAPK150.83772331
66RPS6KA20.82827122
67CSNK1G30.82629371
68CSNK1G20.81924772
69FGFR10.81421630
70EPHA30.81302024
71CDK50.81042160
72TYRO30.78068232
73ERBB40.76440363
74ROCK10.75762736
75MTOR0.75115745
76DYRK1B0.74387283
77CDK120.74066691
78MAP2K40.73671227
79DAPK20.70877220
80STK390.70518048
81PLK20.69641162
82FER0.69403719
83DMPK0.68204066
84MAPK90.67832883
85PHKG10.67579370
86PHKG20.67579370
87PRKCZ0.66405475
88CHEK20.63907139
89CDC42BPA0.63739454
90TRIB30.63549868
91TTN0.63417334
92MOS0.62148844
93PRKCE0.61445510
94WNK40.59827164
95NEK60.59530105
96CAMKK10.59247411
97AKT20.58379734
98EIF2AK20.58177261
99PDGFRB0.58007808
100ABL20.55893712
101PTK60.54104513
102TAOK20.53620408
103CAMK2B0.53235438
104TIE10.52833173
105ATR0.52813965
106STK110.52748574
107TGFBR10.52611697
108EEF2K0.52512428
109ADRBK10.51726813
110CSNK1G10.51184175
111ILK0.50248345
112LMTK20.50115643
113CDK10.49998556
114EPHA40.49995188
115PAK20.49286655
116GRK70.48364086
117SGK2230.47497856
118SGK4940.47497856
119TESK10.47489337
120PLK30.47163352
121CCNB10.47038023
122MARK20.46942933
123CSNK1E0.46811816
124RPS6KA40.45996237
125PRKCG0.45045583
126NUAK10.44040802
127PKN20.43283506
128RIPK10.42198620
129VRK20.42185529
130PKN10.41398640
131CAMK2A0.38224599
132STK38L0.36133220
133GSK3A0.35686815
134CHUK0.32944862
135PIM20.31710176

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.80991812
2* Axon guidance_Homo sapiens_hsa043602.98350469
3Hedgehog signaling pathway_Homo sapiens_hsa043402.88148629
4Hippo signaling pathway_Homo sapiens_hsa043902.53992152
5Nicotine addiction_Homo sapiens_hsa050332.52845369
6Notch signaling pathway_Homo sapiens_hsa043302.31038355
7Wnt signaling pathway_Homo sapiens_hsa043102.16367951
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.06725080
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98895495
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.91500661
11Colorectal cancer_Homo sapiens_hsa052101.88808517
12Melanogenesis_Homo sapiens_hsa049161.85507110
13Endometrial cancer_Homo sapiens_hsa052131.81502288
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62932445
15Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.56321955
16MicroRNAs in cancer_Homo sapiens_hsa052061.51429754
17Cardiac muscle contraction_Homo sapiens_hsa042601.38633783
18Ribosome_Homo sapiens_hsa030101.38328482
19mRNA surveillance pathway_Homo sapiens_hsa030151.37206186
20Circadian entrainment_Homo sapiens_hsa047131.36560950
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35196970
22Adherens junction_Homo sapiens_hsa045201.34254595
23ErbB signaling pathway_Homo sapiens_hsa040121.34008319
24Glutamatergic synapse_Homo sapiens_hsa047241.32818343
25Gap junction_Homo sapiens_hsa045401.31262791
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30351542
27Glioma_Homo sapiens_hsa052141.28792880
28Dopaminergic synapse_Homo sapiens_hsa047281.27440502
29GABAergic synapse_Homo sapiens_hsa047271.18631849
30Cholinergic synapse_Homo sapiens_hsa047251.17449996
31Proteoglycans in cancer_Homo sapiens_hsa052051.17406853
32Cocaine addiction_Homo sapiens_hsa050301.17240474
33Spliceosome_Homo sapiens_hsa030401.16841989
34Steroid biosynthesis_Homo sapiens_hsa001001.14885186
35Morphine addiction_Homo sapiens_hsa050321.14753924
36TGF-beta signaling pathway_Homo sapiens_hsa043501.14129275
37Alcoholism_Homo sapiens_hsa050341.13545182
38Chronic myeloid leukemia_Homo sapiens_hsa052201.11087937
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10454153
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09383012
41Renal cell carcinoma_Homo sapiens_hsa052111.08907831
42Bladder cancer_Homo sapiens_hsa052191.06507339
43Tight junction_Homo sapiens_hsa045301.06358074
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04762143
45Oocyte meiosis_Homo sapiens_hsa041141.03039503
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00752324
47Salmonella infection_Homo sapiens_hsa051321.00520912
48Viral myocarditis_Homo sapiens_hsa054161.00373002
49Cell cycle_Homo sapiens_hsa041100.99876625
50Long-term depression_Homo sapiens_hsa047300.99692817
51Long-term potentiation_Homo sapiens_hsa047200.99044366
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98752397
53Estrogen signaling pathway_Homo sapiens_hsa049150.98294860
54Pathways in cancer_Homo sapiens_hsa052000.97459734
55Vibrio cholerae infection_Homo sapiens_hsa051100.96381583
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95709659
57Taste transduction_Homo sapiens_hsa047420.95157261
58Melanoma_Homo sapiens_hsa052180.94916533
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94293140
60Amphetamine addiction_Homo sapiens_hsa050310.93153235
61Oxidative phosphorylation_Homo sapiens_hsa001900.92448704
62Mineral absorption_Homo sapiens_hsa049780.92115590
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92032292
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91867632
65Focal adhesion_Homo sapiens_hsa045100.91090579
66Prion diseases_Homo sapiens_hsa050200.89668445
67ECM-receptor interaction_Homo sapiens_hsa045120.88580785
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88158964
69Serotonergic synapse_Homo sapiens_hsa047260.87715752
70Oxytocin signaling pathway_Homo sapiens_hsa049210.86737013
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.85876027
72Type II diabetes mellitus_Homo sapiens_hsa049300.85231408
73GnRH signaling pathway_Homo sapiens_hsa049120.83751164
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82976320
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82266381
76Pancreatic cancer_Homo sapiens_hsa052120.81430657
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80532857
78Olfactory transduction_Homo sapiens_hsa047400.80450702
79Synaptic vesicle cycle_Homo sapiens_hsa047210.79855190
80HTLV-I infection_Homo sapiens_hsa051660.79538461
81Non-small cell lung cancer_Homo sapiens_hsa052230.79531486
82Huntingtons disease_Homo sapiens_hsa050160.79395591
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.78860852
84Parkinsons disease_Homo sapiens_hsa050120.77936369
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77459700
86Rap1 signaling pathway_Homo sapiens_hsa040150.75146466
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75047676
88Alzheimers disease_Homo sapiens_hsa050100.74222396
89Dorso-ventral axis formation_Homo sapiens_hsa043200.73687547
90Dilated cardiomyopathy_Homo sapiens_hsa054140.70272283
91Insulin secretion_Homo sapiens_hsa049110.69966256
92Thyroid hormone synthesis_Homo sapiens_hsa049180.69401930
93mTOR signaling pathway_Homo sapiens_hsa041500.69329796
94Gastric acid secretion_Homo sapiens_hsa049710.68501938
95Salivary secretion_Homo sapiens_hsa049700.67601738
96Choline metabolism in cancer_Homo sapiens_hsa052310.66786441
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66095339
98Prostate cancer_Homo sapiens_hsa052150.66069008
99N-Glycan biosynthesis_Homo sapiens_hsa005100.66064284
100Phototransduction_Homo sapiens_hsa047440.65111670
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64281938
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64062736
103Ras signaling pathway_Homo sapiens_hsa040140.63597920
104cAMP signaling pathway_Homo sapiens_hsa040240.63501089
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63166634
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62307582
107Amoebiasis_Homo sapiens_hsa051460.61365262
108Fanconi anemia pathway_Homo sapiens_hsa034600.60903655
109MAPK signaling pathway_Homo sapiens_hsa040100.60552612
110Lysine degradation_Homo sapiens_hsa003100.60175509
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.59727297
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59626089
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58869803
114Systemic lupus erythematosus_Homo sapiens_hsa053220.58667112
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57911901
116Phagosome_Homo sapiens_hsa041450.57884645
117Small cell lung cancer_Homo sapiens_hsa052220.57799162
118Protein digestion and absorption_Homo sapiens_hsa049740.57617192
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57444248
120Renin secretion_Homo sapiens_hsa049240.55385297
121VEGF signaling pathway_Homo sapiens_hsa043700.55347747
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55171830
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.54504325
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54453180
125Sulfur metabolism_Homo sapiens_hsa009200.45334428
126Lysosome_Homo sapiens_hsa041420.44619362
127Fat digestion and absorption_Homo sapiens_hsa049750.42898354
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42846107
129Bile secretion_Homo sapiens_hsa049760.37342986
130Protein export_Homo sapiens_hsa030600.33910644
131Glycerolipid metabolism_Homo sapiens_hsa005610.33696249
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.33254920
133Galactose metabolism_Homo sapiens_hsa000520.31972204

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