EPHB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)5.25053123
2polarized epithelial cell differentiation (GO:0030859)5.06867728
3desmosome organization (GO:0002934)5.02766250
4establishment of apical/basal cell polarity (GO:0035089)4.96545604
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.93660667
6regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.57022754
7paraxial mesoderm development (GO:0048339)4.55972774
8bone trabecula formation (GO:0060346)4.42149237
9establishment or maintenance of monopolar cell polarity (GO:0061339)4.29805187
10establishment of monopolar cell polarity (GO:0061162)4.29805187
11keratinization (GO:0031424)4.27019914
12regulation of cardioblast differentiation (GO:0051890)4.20504006
13lateral sprouting from an epithelium (GO:0060601)4.01216607
14protein heterotrimerization (GO:0070208)3.97003982
15lung-associated mesenchyme development (GO:0060484)3.83630010
16regulation of hippo signaling (GO:0035330)3.82052222
17outer ear morphogenesis (GO:0042473)3.71274332
18negative regulation of chondrocyte differentiation (GO:0032331)3.65172281
19semaphorin-plexin signaling pathway (GO:0071526)3.61456238
20negative regulation of cell fate specification (GO:0009996)3.57417083
21hair cycle (GO:0042633)3.54133475
22molting cycle (GO:0042303)3.54133475
23regulation of transforming growth factor beta2 production (GO:0032909)3.50938553
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50496238
25epithelial cell-cell adhesion (GO:0090136)3.47426039
26hippo signaling (GO:0035329)3.46006011
27establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.41978146
28regulation of posttranscriptional gene silencing (GO:0060147)3.40229022
29regulation of gene silencing by miRNA (GO:0060964)3.40229022
30regulation of gene silencing by RNA (GO:0060966)3.40229022
31collagen fibril organization (GO:0030199)3.39687126
32regulation of axon extension involved in axon guidance (GO:0048841)3.39468233
33chondrocyte proliferation (GO:0035988)3.36873260
34cell-cell junction maintenance (GO:0045217)3.34679901
35atrioventricular valve morphogenesis (GO:0003181)3.33778264
36endodermal cell differentiation (GO:0035987)3.32801077
37notochord development (GO:0030903)3.29913032
38negative regulation of cartilage development (GO:0061037)3.29858291
39eyelid development in camera-type eye (GO:0061029)3.28936649
40camera-type eye morphogenesis (GO:0048593)3.28860476
41skin morphogenesis (GO:0043589)3.25398984
42cell junction maintenance (GO:0034331)3.24410120
43non-canonical Wnt signaling pathway (GO:0035567)3.24312775
44regulation of axon guidance (GO:1902667)3.23974765
45endocardial cushion development (GO:0003197)3.23576336
46negative regulation of keratinocyte proliferation (GO:0010839)3.20373369
47intermediate filament organization (GO:0045109)3.20169917
48embryonic foregut morphogenesis (GO:0048617)3.18634511
49Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.16084948
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.14926708
51axon extension involved in axon guidance (GO:0048846)3.14926708
52basement membrane organization (GO:0071711)3.13486865
53negative regulation of catenin import into nucleus (GO:0035414)3.12463318
54craniofacial suture morphogenesis (GO:0097094)3.11485684
55branching involved in salivary gland morphogenesis (GO:0060445)3.09746722
56ear development (GO:0043583)3.09028997
57embryonic cranial skeleton morphogenesis (GO:0048701)3.08862704
58apical protein localization (GO:0045176)3.08272533
59multicellular organismal water homeostasis (GO:0050891)3.05358295
60regulation of cell fate specification (GO:0042659)3.02809320
61embryonic camera-type eye development (GO:0031076)3.02209332
62regulation of establishment of planar polarity (GO:0090175)3.01504293
63establishment of tissue polarity (GO:0007164)2.98608752
64establishment of planar polarity (GO:0001736)2.98608752
65keratinocyte proliferation (GO:0043616)2.97973373
66cochlea morphogenesis (GO:0090103)2.97856582
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97233746
68asymmetric protein localization (GO:0008105)2.94989071
69convergent extension (GO:0060026)2.94073394
70mesenchyme development (GO:0060485)2.93090846
71anterior/posterior axis specification, embryo (GO:0008595)2.92432461
72cell-substrate junction assembly (GO:0007044)2.91821994
73wound healing, spreading of epidermal cells (GO:0035313)2.91587883
74regulation of water loss via skin (GO:0033561)2.91331646
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.90299870
76epidermis development (GO:0008544)2.84703707
77cardiac right ventricle morphogenesis (GO:0003215)2.84593359
78calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.83771949
79peptidyl-tyrosine autophosphorylation (GO:0038083)2.83720557
80head development (GO:0060322)2.83055685
81regulation of heart morphogenesis (GO:2000826)2.81294344
82cell surface receptor signaling pathway involved in heart development (GO:0061311)2.81225144
83negative regulation of embryonic development (GO:0045992)2.78558778
84cell communication involved in cardiac conduction (GO:0086065)2.78543666
85heart valve morphogenesis (GO:0003179)2.78211668
86cardiac myofibril assembly (GO:0055003)2.77692365
87gastrulation with mouth forming second (GO:0001702)2.77612307
88positive regulation of SMAD protein import into nucleus (GO:0060391)2.76629568
89embryonic skeletal joint morphogenesis (GO:0060272)2.74849081
90negative regulation of axon guidance (GO:1902668)2.74752837
91regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.72287934
92sodium ion export (GO:0071436)2.72187180
93keratinocyte differentiation (GO:0030216)2.71575427
94regulation of SMAD protein import into nucleus (GO:0060390)2.71520593
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.70548745
96limb bud formation (GO:0060174)2.68940133
97peptidyl-proline hydroxylation (GO:0019511)2.67597864
98establishment or maintenance of apical/basal cell polarity (GO:0035088)2.66709700
99establishment or maintenance of bipolar cell polarity (GO:0061245)2.66709700
100organ formation (GO:0048645)2.66035219
101endothelial cell chemotaxis (GO:0035767)2.63251097
102ectoderm development (GO:0007398)2.62332889
103establishment of epithelial cell polarity (GO:0090162)2.62103715
104outflow tract septum morphogenesis (GO:0003148)2.62059133
105establishment of skin barrier (GO:0061436)2.62015805
106dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.61094525
107positive regulation of gastrulation (GO:2000543)2.60753980
108plasma membrane repair (GO:0001778)2.60563469
109regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.60424013
110cranial suture morphogenesis (GO:0060363)2.60029145
111axon extension (GO:0048675)2.59955512
112regulation of catenin import into nucleus (GO:0035412)2.58863880
113renal system development (GO:0072001)2.57993931
114cell proliferation involved in metanephros development (GO:0072203)2.57629258
115negative regulation of stem cell proliferation (GO:2000647)2.57469432
116regulation of tight junction assembly (GO:2000810)2.56928164
117mesenchymal cell proliferation (GO:0010463)2.56303512
118ventricular cardiac muscle cell action potential (GO:0086005)2.55204902
119pattern specification involved in kidney development (GO:0061004)2.55031096
120positive regulation of stem cell differentiation (GO:2000738)2.53854486
121regulation of gastrulation (GO:0010470)2.52525779
122collagen metabolic process (GO:0032963)2.52297409
123mesenchyme morphogenesis (GO:0072132)2.50288829
124regulation of mesenchymal cell proliferation (GO:0010464)2.49410985
125positive regulation of mesenchymal cell proliferation (GO:0002053)2.48755766
126negative regulation of axon extension involved in axon guidance (GO:0048843)2.48376728
127negative regulation of cell fate commitment (GO:0010454)2.48030718
128epidermal cell differentiation (GO:0009913)2.44216352
129cell migration in hindbrain (GO:0021535)2.37965288
130water homeostasis (GO:0030104)2.37360732
131lens morphogenesis in camera-type eye (GO:0002089)2.36633871
132skin development (GO:0043588)2.36285413
133cellular component maintenance (GO:0043954)2.34990986
134regulation of neuron migration (GO:2001222)2.30077707
135cardiac chamber formation (GO:0003207)2.28454774
136negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.27395660
137proximal/distal pattern formation (GO:0009954)2.27271282
138* ephrin receptor signaling pathway (GO:0048013)2.26867692
139branching involved in mammary gland duct morphogenesis (GO:0060444)2.26818163
140hair follicle development (GO:0001942)2.26694755
141dorsal/ventral axis specification (GO:0009950)2.26694378
142heart valve formation (GO:0003188)2.25420611
143* axonal fasciculation (GO:0007413)2.23153722
144developmental cell growth (GO:0048588)2.22941316
145locomotory exploration behavior (GO:0035641)2.22835161
146regulation of heart rate by cardiac conduction (GO:0086091)2.21757103
147regulation of keratinocyte proliferation (GO:0010837)2.21408530
148cardiac conduction (GO:0061337)2.21176804
149neuron projection extension (GO:1990138)2.20621412
150protein retention in ER lumen (GO:0006621)2.20211245
151regulation of endothelial cell chemotaxis (GO:2001026)2.19206778
152cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.19200942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.75010283
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.61672308
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01592587
4ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.70221521
5EZH2_22144423_ChIP-Seq_EOC_Human2.65439145
6* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60878063
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48456937
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43826618
9ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.33838064
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32910786
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32910786
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32910786
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17092412
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16569990
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08964584
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.08718968
17TP53_20018659_ChIP-ChIP_R1E_Mouse2.05714017
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.03564867
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.00294791
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.98535288
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97783919
22ZNF263_19887448_ChIP-Seq_K562_Human1.92777745
23SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91996098
24* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.91896325
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86094431
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85444327
27* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.83452811
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82939690
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.75563273
30CTCF_27219007_Chip-Seq_Bcells_Human1.74166954
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.72669671
32* LXR_22292898_ChIP-Seq_THP-1_Human1.72162565
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.70685831
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69779541
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68859603
36DROSHA_22980978_ChIP-Seq_HELA_Human1.67555456
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66369429
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.65985264
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64168740
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.63710479
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.63671678
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63072763
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62296155
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58137778
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.55381917
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55280246
47* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54451711
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.54337025
49NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53850791
50NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53757258
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52891580
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.52780764
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52229068
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51225402
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.47847340
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47748542
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47546669
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45146292
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44996957
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.44615583
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43549515
62* ISL1_27105846_Chip-Seq_CPCs_Mouse1.43513493
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.43162113
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42469697
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39972721
66* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38364557
67* CBX2_27304074_Chip-Seq_ESCs_Mouse1.38305201
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34273249
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.32138252
70RACK7_27058665_Chip-Seq_MCF-7_Human1.31339123
71POU5F1_16518401_ChIP-PET_MESCs_Mouse1.30642305
72* ATF3_27146783_Chip-Seq_COLON_Human1.30247541
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29886457
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28654616
75* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28397327
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28155429
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26974093
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26974093
79TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.26895966
80* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26400783
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25905972
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.25372885
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.25212414
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24861062
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24591210
86KDM2B_26808549_Chip-Seq_K562_Human1.23608957
87CLOCK_20551151_ChIP-Seq_293T_Human1.23276614
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.21614844
89TP63_22573176_ChIP-Seq_HFKS_Human1.20551181
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19831735
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19151411
92SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19151411
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18057877
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17717425
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.16833572
96CDX2_20551321_ChIP-Seq_CACO-2_Human1.16769792
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16311799
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15126356
99* RNF2_27304074_Chip-Seq_ESCs_Mouse1.14756135
100* KLF5_25053715_ChIP-Seq_YYC3_Human1.13993042
101* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13602845
102TCF4_18268006_ChIP-ChIP_LS174T_Human1.13369963
103CREB1_26743006_Chip-Seq_LNCaP_Human1.12563690
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12230758
105* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12121569
106SMC4_20622854_ChIP-Seq_HELA_Human1.11882329
107AHR_22903824_ChIP-Seq_MCF-7_Human1.11662052
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10266967
109MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10114551
110ELK3_25401928_ChIP-Seq_HUVEC_Human1.10050626
111POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09739307
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09594050
113AR_21909140_ChIP-Seq_LNCAP_Human1.09341819
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08218470
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08070770
116* UBF1/2_26484160_Chip-Seq_HMECs_Human1.08014794
117RING1B_27294783_Chip-Seq_ESCs_Mouse1.07020156
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06627001
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06174553
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06155506
121STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06013769
122BRD4_25478319_ChIP-Seq_HGPS_Human1.05843743
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05284465
124TP53_22127205_ChIP-Seq_IMR90_Human1.04829020
125EGR1_19374776_ChIP-ChIP_THP-1_Human1.03164873
126SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03145380
127ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02570735
128* EP300_21415370_ChIP-Seq_HL-1_Mouse1.02357174
129* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01993402
130KDM2B_26808549_Chip-Seq_DND41_Human1.01537867
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00881025
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99105486
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99093503
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.99064406
135CJUN_26792858_Chip-Seq_BT549_Human0.98611380
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98548349
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98176803
138POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97974938
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.97804808
140PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97665350
141SA1_27219007_Chip-Seq_ERYTHROID_Human0.94502184
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90904532
143P68_20966046_ChIP-Seq_HELA_Human0.90684842
144KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86825900
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84295397
146TET1_21451524_ChIP-Seq_MESCs_Mouse0.82800568
147SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81702319
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.79852771
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.79639937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile3.61749963
2MP0008438_abnormal_cutaneous_collagen3.51413272
3MP0003705_abnormal_hypodermis_morpholog3.27300869
4MP0010030_abnormal_orbit_morphology3.17985130
5MP0003941_abnormal_skin_development2.94684999
6MP0010234_abnormal_vibrissa_follicle2.83874486
7MP0004272_abnormal_basement_membrane2.82935828
8MP0005503_abnormal_tendon_morphology2.62423138
9MP0000537_abnormal_urethra_morphology2.41249126
10MP0005409_darkened_coat_color2.40412156
11MP0005623_abnormal_meninges_morphology2.34871377
12MP0009053_abnormal_anal_canal2.12499971
13MP0000762_abnormal_tongue_morphology2.10881097
14MP0003385_abnormal_body_wall1.92541426
15MP0002249_abnormal_larynx_morphology1.92176772
16MP0002796_impaired_skin_barrier1.90215292
17MP0004381_abnormal_hair_follicle1.86877093
18MP0000049_abnormal_middle_ear1.86661139
19MP0004858_abnormal_nervous_system1.84013112
20MP0002060_abnormal_skin_morphology1.80937340
21MP0009384_cardiac_valve_regurgitation1.78537516
22MP0009250_abnormal_appendicular_skeleto1.76197691
23MP0003283_abnormal_digestive_organ1.70638381
24MP0005508_abnormal_skeleton_morphology1.70628478
25MP0003119_abnormal_digestive_system1.67412058
26MP0003566_abnormal_cell_adhesion1.63577562
27MP0003115_abnormal_respiratory_system1.62573416
28MP0000579_abnormal_nail_morphology1.60611775
29MP0010352_gastrointestinal_tract_polyps1.59421695
30MP0000566_synostosis1.59075199
31MP0001849_ear_inflammation1.57855456
32MP0003755_abnormal_palate_morphology1.56424280
33MP0002282_abnormal_trachea_morphology1.55743979
34MP0000534_abnormal_ureter_morphology1.55394916
35MP0003942_abnormal_urinary_system1.55014721
36MP0003937_abnormal_limbs/digits/tail_de1.54833428
37MP0005076_abnormal_cell_differentiation1.54818090
38MP0005257_abnormal_intraocular_pressure1.53695365
39MP0000383_abnormal_hair_follicle1.51100277
40MP0001958_emphysema1.49774859
41MP0010678_abnormal_skin_adnexa1.49357718
42MP0003279_aneurysm1.47282406
43MP0000778_abnormal_nervous_system1.44888494
44MP0000428_abnormal_craniofacial_morphol1.43340007
45MP0003123_paternal_imprinting1.42686071
46MP0005171_absent_coat_pigmentation1.42157041
47MP0009379_abnormal_foot_pigmentation1.39525773
48MP0000733_abnormal_muscle_development1.38957666
49MP0002234_abnormal_pharynx_morphology1.37804326
50MP0002098_abnormal_vibrissa_morphology1.35596365
51MP0000516_abnormal_urinary_system1.33807883
52MP0005367_renal/urinary_system_phenotyp1.33807883
53MP0005501_abnormal_skin_physiology1.32094281
54MP0002233_abnormal_nose_morphology1.30876440
55MP0003935_abnormal_craniofacial_develop1.30473571
56MP0000432_abnormal_head_morphology1.28890417
57MP0002932_abnormal_joint_morphology1.28228426
58MP0000467_abnormal_esophagus_morphology1.27603407
59MP0004885_abnormal_endolymph1.24754143
60MP0003122_maternal_imprinting1.24589704
61MP0003567_abnormal_fetal_cardiomyocyte1.23665529
62MP0002697_abnormal_eye_size1.20943822
63MP0002116_abnormal_craniofacial_bone1.20766412
64MP0006054_spinal_hemorrhage1.20642403
65MP0002111_abnormal_tail_morphology1.18680095
66MP0004197_abnormal_fetal_growth/weight/1.17548724
67MP0000462_abnormal_digestive_system1.17363796
68MP0005248_abnormal_Harderian_gland1.15915809
69MP0008789_abnormal_olfactory_epithelium1.15690885
70MP0005377_hearing/vestibular/ear_phenot1.15517385
71MP0003878_abnormal_ear_physiology1.15517385
72MP0002084_abnormal_developmental_patter1.14352935
73MP0000427_abnormal_hair_cycle1.12900812
74MP0005499_abnormal_olfactory_system1.10706776
75MP0005394_taste/olfaction_phenotype1.10706776
76MP0002108_abnormal_muscle_morphology1.09508029
77MP0002085_abnormal_embryonic_tissue1.05220949
78MP0002254_reproductive_system_inflammat1.05057040
79MP0010771_integument_phenotype1.04611565
80MP0000647_abnormal_sebaceous_gland1.02859922
81MP0005023_abnormal_wound_healing1.02789546
82MP0002822_catalepsy0.99072048
83MP0001293_anophthalmia0.99068116
84MP0002653_abnormal_ependyma_morphology0.98991538
85MP0000026_abnormal_inner_ear0.98396148
86MP0001216_abnormal_epidermal_layer0.95955411
87MP0005423_abnormal_somatic_nervous0.94873043
88MP0004957_abnormal_blastocyst_morpholog0.94768925
89MP0002109_abnormal_limb_morphology0.94446654
90MP0000377_abnormal_hair_follicle0.94064045
91MP0002896_abnormal_bone_mineralization0.92805342
92MP0003938_abnormal_ear_development0.92762647
93MP0003453_abnormal_keratinocyte_physiol0.91447602
94MP0000538_abnormal_urinary_bladder0.91186743
95MP0004782_abnormal_surfactant_physiolog0.90459030
96MP0002114_abnormal_axial_skeleton0.89087285
97MP0002086_abnormal_extraembryonic_tissu0.88869322
98MP0000163_abnormal_cartilage_morphology0.88711831
99MP0001286_abnormal_eye_development0.88201111
100MP0001340_abnormal_eyelid_morphology0.87633620
101MP0000678_abnormal_parathyroid_gland0.87113053
102MP0002925_abnormal_cardiovascular_devel0.86784781
103MP0001243_abnormal_dermal_layer0.85597433
104MP0001672_abnormal_embryogenesis/_devel0.84464172
105MP0005380_embryogenesis_phenotype0.84464172
106MP0001299_abnormal_eye_distance/0.83662573
107MP0004133_heterotaxia0.83272081
108MP0003315_abnormal_perineum_morphology0.82210678
109MP0003121_genomic_imprinting0.81477466
110MP0001502_abnormal_circadian_rhythm0.80993378
111MP0000751_myopathy0.79797803
112MP0003091_abnormal_cell_migration0.79641406
113MP0002092_abnormal_eye_morphology0.79472615
114MP0009780_abnormal_chondrocyte_physiolo0.79021767
115MP0004264_abnormal_extraembryonic_tissu0.78396917
116MP0006138_congestive_heart_failure0.78261437
117MP0002088_abnormal_embryonic_growth/wei0.77738346
118* MP0003861_abnormal_nervous_system0.77446288
119MP0002115_abnormal_skeleton_extremities0.77242050
120MP0001346_abnormal_lacrimal_gland0.77122282
121MP0004859_abnormal_synaptic_plasticity0.71052302
122MP0009931_abnormal_skin_appearance0.70370866
123MP0003880_abnormal_central_pattern0.68860542
124MP0004084_abnormal_cardiac_muscle0.67042290
125MP0000367_abnormal_coat/_hair0.66033990
126MP0002089_abnormal_postnatal_growth/wei0.64902412
127MP0002184_abnormal_innervation0.64504048
128MP0001485_abnormal_pinna_reflex0.64121491
129MP0002938_white_spotting0.62586243

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.64965285
2Abnormality of nail color (HP:0100643)4.48003993
3Premature rupture of membranes (HP:0001788)4.47271895
4Atrophic scars (HP:0001075)4.39925760
5Shallow orbits (HP:0000586)4.21224849
6Obstructive sleep apnea (HP:0002870)3.42592263
7Ankle contracture (HP:0006466)3.40306971
8Milia (HP:0001056)3.14241381
9Right ventricular cardiomyopathy (HP:0011663)3.09301144
10Fragile skin (HP:0001030)2.98898016
11Neonatal short-limb short stature (HP:0008921)2.96036851
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.89522235
13Short 4th metacarpal (HP:0010044)2.89522235
14Thick nail (HP:0001805)2.75123047
15Broad metatarsal (HP:0001783)2.71933336
16Palmoplantar hyperkeratosis (HP:0000972)2.71910826
17Fragile nails (HP:0001808)2.66527836
18Follicular hyperkeratosis (HP:0007502)2.64162252
19Onycholysis (HP:0001806)2.60013255
20Cerebral aneurysm (HP:0004944)2.58903639
21Palmar hyperkeratosis (HP:0010765)2.57757668
22Type 1 muscle fiber predominance (HP:0003803)2.55151657
23Abnormality of dentin (HP:0010299)2.53024955
24Mildly elevated creatine phosphokinase (HP:0008180)2.51682306
25Abnormal hair laboratory examination (HP:0003328)2.48834409
26Flat acetabular roof (HP:0003180)2.47414145
27Thin bony cortex (HP:0002753)2.44393598
28Abnormality of the 4th metacarpal (HP:0010012)2.44187002
29Selective tooth agenesis (HP:0001592)2.43109647
30Genu recurvatum (HP:0002816)2.37833011
31Alopecia of scalp (HP:0002293)2.37405514
32Coronal craniosynostosis (HP:0004440)2.35514598
33Bladder diverticulum (HP:0000015)2.34660556
34Aortic dissection (HP:0002647)2.33891383
35Hypotrichosis (HP:0001006)2.32665931
36Vitreoretinal degeneration (HP:0000655)2.29385564
37Laryngomalacia (HP:0001601)2.26966204
38Distal upper limb amyotrophy (HP:0007149)2.24139604
39Upper limb amyotrophy (HP:0009129)2.24139604
40Morphological abnormality of the middle ear (HP:0008609)2.21232531
41Pili torti (HP:0003777)2.20388618
42Limited hip movement (HP:0008800)2.18498130
43Abnormality of the aortic arch (HP:0012303)2.17395062
44Wrist flexion contracture (HP:0001239)2.16014848
45Lip pit (HP:0100267)2.15318374
46Abnormality of the distal phalanges of the toes (HP:0010182)2.14298889
47Soft skin (HP:0000977)2.12620102
48Spinal rigidity (HP:0003306)2.11739302
49Ventricular tachycardia (HP:0004756)2.09917350
50Increased connective tissue (HP:0009025)2.07753857
51Hand muscle atrophy (HP:0009130)2.07068868
52Aplasia of the musculature (HP:0100854)2.04428830
53Renal duplication (HP:0000075)2.02820375
54Aplasia of the phalanges of the hand (HP:0009802)2.02048479
55Aplasia involving bones of the extremities (HP:0009825)2.02048479
56Aplasia involving bones of the upper limbs (HP:0009823)2.02048479
57Abnormal vertebral ossification (HP:0100569)2.01670099
58Mitral valve prolapse (HP:0001634)2.01637565
59Deviation of the hallux (HP:0010051)1.97646883
60Dilatation of the ascending aorta (HP:0005111)1.97431926
61Woolly hair (HP:0002224)1.96798391
62Pterygium (HP:0001059)1.95442903
63Short phalanx of the thumb (HP:0009660)1.92102091
64Sleep apnea (HP:0010535)1.91930406
65Lymphangioma (HP:0100764)1.91304072
66Blue sclerae (HP:0000592)1.90982594
67Stridor (HP:0010307)1.89210822
68Abnormality of the fetal cardiovascular system (HP:0010948)1.89201705
69Abnormal umbilical cord blood vessels (HP:0011403)1.89201705
70Single umbilical artery (HP:0001195)1.89201705
71Esophageal atresia (HP:0002032)1.89035464
72Broad face (HP:0000283)1.88374963
73Flattened epiphyses (HP:0003071)1.88058619
74Abnormality of the phalanges of the hallux (HP:0010057)1.87478791
75Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.87049359
76Cervical subluxation (HP:0003308)1.86675124
77Broad toe (HP:0001837)1.86239372
78Wide anterior fontanel (HP:0000260)1.85936789
79Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85757185
80Short 1st metacarpal (HP:0010034)1.85757185
81Hyperacusis (HP:0010780)1.85701333
82Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.85263530
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.84875572
84Hallux valgus (HP:0001822)1.83965486
85Abnormality of the 2nd finger (HP:0004100)1.83461235
86Mesomelia (HP:0003027)1.83183410
87Ridged nail (HP:0001807)1.81579423
88Delayed epiphyseal ossification (HP:0002663)1.81383474
89Plantar hyperkeratosis (HP:0007556)1.81242447
90Hypoplasia of the iris (HP:0007676)1.81154664
91Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.81127018
92Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.80542629
93Natal tooth (HP:0000695)1.79223912
94Hip contracture (HP:0003273)1.76625029
95Down-sloping shoulders (HP:0200021)1.76314847
96Diaphragmatic weakness (HP:0009113)1.76138234
97Hypoplastic ischia (HP:0003175)1.75774466
98Broad long bones (HP:0005622)1.74922207
99Turricephaly (HP:0000262)1.74797266
100Abnormality of the parietal bone (HP:0002696)1.74742160
101Short femoral neck (HP:0100864)1.74510153
102Short middle phalanx of the 5th finger (HP:0004220)1.73931947
103Bronchomalacia (HP:0002780)1.73623536
104Broad thumb (HP:0011304)1.73537891
105Severe Myopia (HP:0011003)1.73207541
106Slender build (HP:0001533)1.72953982
107Preaxial foot polydactyly (HP:0001841)1.71842300
108Short hallux (HP:0010109)1.70924896
109Flat capital femoral epiphysis (HP:0003370)1.70799961
110Abnormality of the ischium (HP:0003174)1.69846685
111Elbow flexion contracture (HP:0002987)1.69734553
112Nail dystrophy (HP:0008404)1.69556312
113Abnormality of the 1st metacarpal (HP:0010009)1.69265484
114Hyperextensible skin (HP:0000974)1.69037598
115Cutaneous finger syndactyly (HP:0010554)1.68809141
116Tibial bowing (HP:0002982)1.67907712
117Overgrowth (HP:0001548)1.67264908
118Renal dysplasia (HP:0000110)1.66982677
119Periauricular skin pits (HP:0100277)1.66378256
120Preauricular pit (HP:0004467)1.66378256
121Abnormality of the salivary glands (HP:0010286)1.66112072
122Thin ribs (HP:0000883)1.65604685
123Cutaneous syndactyly (HP:0012725)1.65308376
124Ulnar bowing (HP:0003031)1.65130780
125Ankyloglossia (HP:0010296)1.64980431
126Narrow nasal bridge (HP:0000446)1.64837568
127Wormian bones (HP:0002645)1.64422420
128Congenital ichthyosiform erythroderma (HP:0007431)1.64409208
129Popliteal pterygium (HP:0009756)1.64406184
130Partial duplication of thumb phalanx (HP:0009944)1.64318072
131Partial duplication of the phalanx of hand (HP:0009999)1.64279993
132Alacrima (HP:0000522)1.64243818
133Shawl scrotum (HP:0000049)1.64126910
134Skin pits (HP:0100276)1.63744367
135Fused cervical vertebrae (HP:0002949)1.63363108
136Advanced eruption of teeth (HP:0006288)1.63358895
137Rib fusion (HP:0000902)1.63353319
138Breech presentation (HP:0001623)1.62977157
139Bell-shaped thorax (HP:0001591)1.62784894
140Midline defect of the nose (HP:0004122)1.62285460
141Anophthalmia (HP:0000528)1.61692759
142Hip dysplasia (HP:0001385)1.61569642
143Short 5th finger (HP:0009237)1.60743023
144Trismus (HP:0000211)1.60059914
145Distal lower limb muscle weakness (HP:0009053)1.59788218
146Abnormality of the middle phalanges of the toes (HP:0010183)1.59442824
147Peritonitis (HP:0002586)1.59044829
148Aplasia cutis congenita (HP:0001057)1.58916586
149Bowel diverticulosis (HP:0005222)1.58916510
150Sparse scalp hair (HP:0002209)1.58895099
151Mitral regurgitation (HP:0001653)1.55603357
152Exostoses (HP:0100777)1.55039813
153Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.54109001
154Neoplasm of the heart (HP:0100544)1.53285811
155Infantile muscular hypotonia (HP:0008947)1.52331523
156Tracheomalacia (HP:0002779)1.51907051
157Abnormality of the proximal phalanges of the hand (HP:0009834)1.50108586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.23693404
2DDR24.46606700
3LATS23.22643979
4LATS13.20925607
5EPHB22.90268962
6PDGFRA2.78570830
7CDK122.72718779
8TRIB32.59147714
9MAPK152.43988259
10MAP3K62.19547186
11FER2.08844276
12RIPK12.08204140
13MARK12.06335613
14CASK2.01005300
15TTN1.95068436
16STK38L1.88076048
17MUSK1.87330813
18PAK41.82275267
19NTRK11.69033521
20ICK1.68566229
21MARK21.59488626
22BMX1.57787010
23MAP3K101.51827719
24TYRO31.50907563
25DMPK1.49456391
26PKN21.44648737
27PRKD31.39661664
28FGFR11.38760302
29SIK11.38227847
30RPS6KB21.37778863
31AKT31.32268047
32PTK21.31379735
33MET1.25103151
34EEF2K1.24523961
35TTK1.17068464
36STK391.16826056
37RPS6KA21.15796836
38PTK61.12352330
39KSR11.11952666
40TAOK21.06493008
41EPHB11.04270540
42STK31.03509539
43MST1R1.03506521
44LMTK21.02950769
45MAP3K71.02568508
46NTRK21.02496401
47MTOR0.99446120
48PRKCI0.99370427
49WNK40.97659650
50CDK70.93380132
51NME10.90912640
52NEK10.90150608
53MAP3K90.89303078
54CDK60.84948104
55TNK20.83629859
56PIM20.82601714
57MAPKAPK30.80013905
58PAK20.79361786
59FGFR40.79146372
60PAK30.78480636
61NTRK30.78424848
62SMG10.77504080
63NEK20.77448845
64PDGFRB0.77357221
65MAP2K20.76946931
66EPHA40.75284741
67STK380.74609262
68ERBB20.73130105
69MAP2K10.72058444
70ILK0.71429469
71ERBB30.70830740
72RET0.70803062
73DYRK20.69653182
74CDC42BPA0.65650888
75FGFR20.65597091
76ROCK10.64908225
77NEK60.64198244
78PRPF4B0.63846821
79CDK40.62911368
80AKT20.62348941
81LRRK20.61409318
82TRPM70.59362842
83MAP3K30.59127187
84MAP3K20.59085856
85MATK0.57568450
86EPHA30.57554958
87PLK10.56396566
88DYRK1B0.55232324
89AURKB0.54830509
90MAP3K80.53750437
91DYRK30.53385814
92CAMK1G0.52728054
93CAMK1D0.51904412
94WEE10.50594174
95PAK10.50401952
96PLK20.49762487
97ALK0.48298537
98STK240.48246110
99BCR0.48107840
100OBSCN0.47890443
101RPS6KA60.47566961
102SGK2230.46876863
103SGK4940.46876863
104RPS6KA40.46825453
105CSNK1E0.46767002
106PRKAA10.45607999
107TESK10.45434027
108PLK30.44634394
109RPS6KC10.43693592
110RPS6KL10.43693592
111CDC70.43436432
112DAPK30.42903638
113RPS6KA10.41338721
114ARAF0.41239802
115AURKA0.41067187
116CHEK10.41020271
117ROCK20.40084430
118ZAK0.38567070
119PHKG20.38444287
120PHKG10.38444287
121PIK3CA0.38083757
122TAOK10.36943023
123CAMK10.36836993
124MAPK80.36730171
125MAPK10.36083820
126TGFBR10.35667249
127ERN10.35053686
128CDK20.34876944
129MINK10.34536477
130PRKD10.33992969
131ADRBK10.33606068
132CHUK0.33261489
133CSNK1D0.32931525
134CHEK20.32871096
135PRKD20.32870849
136CAMK2G0.32764471
137TNIK0.31557768
138AKT10.30721733
139MAP2K40.30230867
140SRC0.29962964
141FGR0.29542749
142CDK50.29453740
143PRKCZ0.28558524
144MAP2K70.27324886
145MAPK70.26621522

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.67980609
2ECM-receptor interaction_Homo sapiens_hsa045123.42649185
3Hippo signaling pathway_Homo sapiens_hsa043902.99743326
4Hedgehog signaling pathway_Homo sapiens_hsa043402.92200003
5Adherens junction_Homo sapiens_hsa045202.46575732
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.29131733
7Focal adhesion_Homo sapiens_hsa045102.23633814
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.15977242
9Tight junction_Homo sapiens_hsa045302.11505067
10Bladder cancer_Homo sapiens_hsa052192.02944457
11Small cell lung cancer_Homo sapiens_hsa052222.01609832
12Proteoglycans in cancer_Homo sapiens_hsa052052.00145105
13Wnt signaling pathway_Homo sapiens_hsa043101.97838028
14Protein digestion and absorption_Homo sapiens_hsa049741.89823429
15TGF-beta signaling pathway_Homo sapiens_hsa043501.85562450
16Amoebiasis_Homo sapiens_hsa051461.78296981
17MicroRNAs in cancer_Homo sapiens_hsa052061.75678736
18Dilated cardiomyopathy_Homo sapiens_hsa054141.69832132
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68643589
20Melanogenesis_Homo sapiens_hsa049161.66761872
21Notch signaling pathway_Homo sapiens_hsa043301.66430596
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.64294165
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38605415
24* Axon guidance_Homo sapiens_hsa043601.38506853
25Pathways in cancer_Homo sapiens_hsa052001.37097644
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.35087807
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32436047
28Melanoma_Homo sapiens_hsa052181.26287742
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22310802
30Cell cycle_Homo sapiens_hsa041101.18767765
31Endometrial cancer_Homo sapiens_hsa052131.18485897
32HTLV-I infection_Homo sapiens_hsa051661.14960678
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14888668
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14880628
35p53 signaling pathway_Homo sapiens_hsa041151.14647715
36RNA transport_Homo sapiens_hsa030131.12430266
37Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10093262
38Glioma_Homo sapiens_hsa052141.07194153
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05367670
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04240175
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.03245702
42Chronic myeloid leukemia_Homo sapiens_hsa052201.01664091
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01657463
44Colorectal cancer_Homo sapiens_hsa052101.01483204
45Rap1 signaling pathway_Homo sapiens_hsa040150.99730718
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97360515
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97120851
48Lysine degradation_Homo sapiens_hsa003100.94892348
49Spliceosome_Homo sapiens_hsa030400.93267056
50GnRH signaling pathway_Homo sapiens_hsa049120.92782435
51Linoleic acid metabolism_Homo sapiens_hsa005910.92265587
52Ovarian steroidogenesis_Homo sapiens_hsa049130.91691052
53mTOR signaling pathway_Homo sapiens_hsa041500.90179246
54Thyroid cancer_Homo sapiens_hsa052160.88402411
55Steroid biosynthesis_Homo sapiens_hsa001000.88302566
56Prostate cancer_Homo sapiens_hsa052150.87280238
57mRNA surveillance pathway_Homo sapiens_hsa030150.87201190
58Estrogen signaling pathway_Homo sapiens_hsa049150.87118045
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86591006
60Gap junction_Homo sapiens_hsa045400.86159261
61Circadian entrainment_Homo sapiens_hsa047130.85922910
62ErbB signaling pathway_Homo sapiens_hsa040120.85900767
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83571199
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.83338069
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83231817
66Bile secretion_Homo sapiens_hsa049760.82325200
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.81928459
68Cocaine addiction_Homo sapiens_hsa050300.81533711
69Oocyte meiosis_Homo sapiens_hsa041140.78622079
70Glutamatergic synapse_Homo sapiens_hsa047240.75874923
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75700508
72Inositol phosphate metabolism_Homo sapiens_hsa005620.75465925
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75092423
74Insulin secretion_Homo sapiens_hsa049110.75070458
75Dorso-ventral axis formation_Homo sapiens_hsa043200.74617812
76cAMP signaling pathway_Homo sapiens_hsa040240.74500889
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72887352
78Renal cell carcinoma_Homo sapiens_hsa052110.72708272
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71785866
80Renin secretion_Homo sapiens_hsa049240.70747792
81Viral myocarditis_Homo sapiens_hsa054160.70631747
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69845958
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69225252
84VEGF signaling pathway_Homo sapiens_hsa043700.69191016
85Histidine metabolism_Homo sapiens_hsa003400.68975681
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.68467296
87HIF-1 signaling pathway_Homo sapiens_hsa040660.67979994
88Ether lipid metabolism_Homo sapiens_hsa005650.66464924
89Sphingolipid metabolism_Homo sapiens_hsa006000.65516853
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65506267
91Dopaminergic synapse_Homo sapiens_hsa047280.65179045
92Cholinergic synapse_Homo sapiens_hsa047250.64260269
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63057445
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61392965
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60363129
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.60190139
97Pancreatic secretion_Homo sapiens_hsa049720.59867209
98Glycerolipid metabolism_Homo sapiens_hsa005610.57330674
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57186944
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56881499
101Mineral absorption_Homo sapiens_hsa049780.56270370
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55928418
103Vibrio cholerae infection_Homo sapiens_hsa051100.55066499
104Non-small cell lung cancer_Homo sapiens_hsa052230.54826429
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54104290
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53984309
107Toxoplasmosis_Homo sapiens_hsa051450.53665789
108Fructose and mannose metabolism_Homo sapiens_hsa000510.53311288
109Viral carcinogenesis_Homo sapiens_hsa052030.52663084
110Ras signaling pathway_Homo sapiens_hsa040140.52561054
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52463765
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51857241
113Insulin resistance_Homo sapiens_hsa049310.51719078
114Taste transduction_Homo sapiens_hsa047420.51299344
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51258506
116Oxytocin signaling pathway_Homo sapiens_hsa049210.50729817
117MAPK signaling pathway_Homo sapiens_hsa040100.50641998
118Cardiac muscle contraction_Homo sapiens_hsa042600.49321112
119Gastric acid secretion_Homo sapiens_hsa049710.47968213
120Pancreatic cancer_Homo sapiens_hsa052120.45078447
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44358321
122Insulin signaling pathway_Homo sapiens_hsa049100.44201062
123FoxO signaling pathway_Homo sapiens_hsa040680.43854724
124Base excision repair_Homo sapiens_hsa034100.43763652
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.42946368
126Salivary secretion_Homo sapiens_hsa049700.40582183
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38958006
128Long-term potentiation_Homo sapiens_hsa047200.38735815
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.37965690
130Choline metabolism in cancer_Homo sapiens_hsa052310.37454052
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37014158
132Long-term depression_Homo sapiens_hsa047300.36563546
133AMPK signaling pathway_Homo sapiens_hsa041520.35174211
134Renin-angiotensin system_Homo sapiens_hsa046140.35107559
135One carbon pool by folate_Homo sapiens_hsa006700.34312286
136Thyroid hormone synthesis_Homo sapiens_hsa049180.33383344

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