EPHB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)3.95312244
2paraxial mesoderm development (GO:0048339)3.83579267
3basement membrane organization (GO:0071711)3.72081589
4polarized epithelial cell differentiation (GO:0030859)3.69438357
5vascular endothelial growth factor signaling pathway (GO:0038084)3.63006169
6semaphorin-plexin signaling pathway (GO:0071526)3.62117380
7hemidesmosome assembly (GO:0031581)3.61993043
8Golgi transport vesicle coating (GO:0048200)3.55767188
9COPI coating of Golgi vesicle (GO:0048205)3.55767188
10hippo signaling (GO:0035329)3.47487047
11proline biosynthetic process (GO:0006561)3.37836600
12renal filtration (GO:0097205)3.32912456
13planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31873500
14protein retention in ER lumen (GO:0006621)3.31537541
15midgut development (GO:0007494)3.31177928
16endothelial cell morphogenesis (GO:0001886)3.27523896
17cardiac myofibril assembly (GO:0055003)3.26803807
18establishment of apical/basal cell polarity (GO:0035089)3.26216858
19apoptotic process involved in morphogenesis (GO:0060561)3.26090375
20convergent extension (GO:0060026)3.24341237
21epithelial cell-cell adhesion (GO:0090136)3.22521295
22regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22276580
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20212552
24regulation of hippo signaling (GO:0035330)3.16628141
25positive regulation of fatty acid beta-oxidation (GO:0032000)3.16273756
26lymphangiogenesis (GO:0001946)3.13795965
27regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11495693
28lymph vessel development (GO:0001945)3.10585078
29regulation of cardioblast differentiation (GO:0051890)3.09748437
30regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07480267
31retina vasculature morphogenesis in camera-type eye (GO:0061299)3.07304489
32plasma membrane repair (GO:0001778)3.07148320
33glomerular filtration (GO:0003094)3.06214035
34regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03389678
35negative regulation of fatty acid transport (GO:2000192)3.03075642
36protein heterotrimerization (GO:0070208)3.01543470
37neuron projection extension involved in neuron projection guidance (GO:1902284)2.99387938
38axon extension involved in axon guidance (GO:0048846)2.99387938
39heterochromatin organization (GO:0070828)2.98837715
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.98695935
41endocardial cushion development (GO:0003197)2.97939310
42negative regulation of cell size (GO:0045792)2.95941021
43embryonic foregut morphogenesis (GO:0048617)2.95001403
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.93776360
45maternal placenta development (GO:0001893)2.91555720
46lysine catabolic process (GO:0006554)2.89171343
47lysine metabolic process (GO:0006553)2.89171343
48cell-substrate junction assembly (GO:0007044)2.89029296
49regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.86642331
50activation of Rac GTPase activity (GO:0032863)2.85347876
51branching involved in salivary gland morphogenesis (GO:0060445)2.85303537
52peptidyl-arginine omega-N-methylation (GO:0035247)2.83275920
53cell migration involved in heart development (GO:0060973)2.81865495
54gap junction assembly (GO:0016264)2.80520695
55protein complex localization (GO:0031503)2.80103398
56regulation of fatty acid beta-oxidation (GO:0031998)2.79709388
57branching involved in mammary gland duct morphogenesis (GO:0060444)2.79677644
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.79306325
59regulation of translational fidelity (GO:0006450)2.78948739
60heart trabecula formation (GO:0060347)2.77610184
61endothelium development (GO:0003158)2.76981529
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.75737554
63regulation of establishment of planar polarity (GO:0090175)2.75260389
64regulation of heart morphogenesis (GO:2000826)2.74317061
65sarcomere organization (GO:0045214)2.74089059
66adherens junction assembly (GO:0034333)2.72429538
67chondrocyte proliferation (GO:0035988)2.71324505
68embryonic eye morphogenesis (GO:0048048)2.71007199
69desmosome organization (GO:0002934)2.70042856
70renal system development (GO:0072001)2.70014450
71endodermal cell differentiation (GO:0035987)2.69754661
72embryonic skeletal joint morphogenesis (GO:0060272)2.67556965
73negative regulation of cartilage development (GO:0061037)2.67414641
74insulin-like growth factor receptor signaling pathway (GO:0048009)2.67335451
75* blood vessel endothelial cell migration (GO:0043534)2.66936413
76negative regulation of fibrinolysis (GO:0051918)2.66604027
77negative regulation of chondrocyte differentiation (GO:0032331)2.65655862
78trabecula formation (GO:0060343)2.64806531
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.64649568
80neural tube development (GO:0021915)2.64383497
81regulation of endothelial cell differentiation (GO:0045601)2.63823667
82negative regulation of cell fate specification (GO:0009996)2.62771374
83positive regulation of fatty acid oxidation (GO:0046321)2.61760763
84cellular protein complex localization (GO:0034629)2.60922573
854-hydroxyproline metabolic process (GO:0019471)2.60817675
86proline metabolic process (GO:0006560)2.60754160
87bone trabecula formation (GO:0060346)2.59961011
88notochord development (GO:0030903)2.58940292
89collagen fibril organization (GO:0030199)2.58007202
90histone arginine methylation (GO:0034969)2.57941873
91establishment of monopolar cell polarity (GO:0061162)2.57848113
92establishment or maintenance of monopolar cell polarity (GO:0061339)2.57848113
93regulation of tight junction assembly (GO:2000810)2.57164975
94regulation of cholesterol homeostasis (GO:2000188)2.57161538
95regulation of glucose import in response to insulin stimulus (GO:2001273)2.56642938
96ear development (GO:0043583)2.54666312
97non-canonical Wnt signaling pathway (GO:0035567)2.54227111
98endothelial tube morphogenesis (GO:0061154)2.54152401
99morphogenesis of an endothelium (GO:0003159)2.54152401
100apoptotic cell clearance (GO:0043277)2.52661523
101retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52492161
102atrioventricular valve morphogenesis (GO:0003181)2.52356365
103outer ear morphogenesis (GO:0042473)2.51048906
104patterning of blood vessels (GO:0001569)2.50884249
105wound healing, spreading of epidermal cells (GO:0035313)2.50111644
106anatomical structure regression (GO:0060033)2.49836933
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49111348
108* cell migration involved in sprouting angiogenesis (GO:0002042)2.48820487
109regulation of cell fate specification (GO:0042659)2.48306971
110DNA unwinding involved in DNA replication (GO:0006268)2.48082142
111glomerular basement membrane development (GO:0032836)2.47075617
112regulation of catenin import into nucleus (GO:0035412)2.47070722
113endothelial cell chemotaxis (GO:0035767)2.46062607
114vasculogenesis (GO:0001570)2.45742475
115regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45212366
116negative regulation of cell fate commitment (GO:0010454)2.44715990
117glucose catabolic process (GO:0006007)2.44564902
118glyoxylate metabolic process (GO:0046487)2.43096910
119regulation of SMAD protein import into nucleus (GO:0060390)2.42836798
120gastrulation with mouth forming second (GO:0001702)2.42810501
121negative regulation of focal adhesion assembly (GO:0051895)2.42302135
122negative regulation of cell junction assembly (GO:1901889)2.42302135
123negative regulation of adherens junction organization (GO:1903392)2.42302135
124anterior/posterior axis specification, embryo (GO:0008595)2.42057257
125myofibril assembly (GO:0030239)2.41739248
126cell surface receptor signaling pathway involved in heart development (GO:0061311)2.39931150
127blood vessel maturation (GO:0001955)2.39479743
128embryonic camera-type eye morphogenesis (GO:0048596)2.38737442
129mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.38643237
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38270383
131adherens junction organization (GO:0034332)2.37992247
132cochlea morphogenesis (GO:0090103)2.37861549
133cell proliferation involved in metanephros development (GO:0072203)2.37543598
134cell adhesion mediated by integrin (GO:0033627)2.37235396
135fatty acid transmembrane transport (GO:1902001)2.36947884
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.36565147
137establishment or maintenance of apical/basal cell polarity (GO:0035088)2.35895206
138establishment or maintenance of bipolar cell polarity (GO:0061245)2.35895206
139positive regulation of glycogen biosynthetic process (GO:0045725)2.35872260
140L-alpha-amino acid transmembrane transport (GO:1902475)2.35523418
141epoxygenase P450 pathway (GO:0019373)2.35156598
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.35088872
143cardiac muscle cell development (GO:0055013)2.34740719
144sulfur amino acid catabolic process (GO:0000098)2.34600913
145regulation of cholesterol biosynthetic process (GO:0045540)2.34437053
146focal adhesion assembly (GO:0048041)2.34388371
147cell-substrate adherens junction assembly (GO:0007045)2.34388371
148regulation of fatty acid oxidation (GO:0046320)2.34341525
149mesenchyme development (GO:0060485)2.32990568
150glomerular visceral epithelial cell development (GO:0072015)2.32252214
151cellular response to epidermal growth factor stimulus (GO:0071364)2.32246436
152positive regulation of catenin import into nucleus (GO:0035413)2.31718017
153vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.31310375
154eye morphogenesis (GO:0048592)2.30965842
155skin morphogenesis (GO:0043589)2.30913338
156protein localization to endosome (GO:0036010)2.30625661
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30520950
158negative regulation of catenin import into nucleus (GO:0035414)2.29573303
159carnitine shuttle (GO:0006853)2.29036593
160mesodermal cell differentiation (GO:0048333)2.28786417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.77508433
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32666932
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20118851
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.41417718
5CLOCK_20551151_ChIP-Seq_293T_Human3.33260242
6E2F7_22180533_ChIP-Seq_HELA_Human3.17608053
7TRIM28_21343339_ChIP-Seq_HEK293_Human3.06762358
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.94652455
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.85870873
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72603906
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72331173
12ZNF263_19887448_ChIP-Seq_K562_Human2.67695883
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.56374115
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.21329496
15HIF1A_21447827_ChIP-Seq_MCF-7_Human2.17872646
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02749845
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.01503405
18* ELK3_25401928_ChIP-Seq_HUVEC_Human1.95976728
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95493745
20ESR1_21235772_ChIP-Seq_MCF-7_Human1.93798245
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91268897
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89011579
23EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.85863939
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85576408
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.79924336
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78336091
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.77803182
28* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76012287
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74622907
30* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73799578
31RACK7_27058665_Chip-Seq_MCF-7_Human1.70893543
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.66059233
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.65630891
34MYC_22102868_ChIP-Seq_BL_Human1.65291388
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.63517569
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62102056
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62024527
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.61641155
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61533565
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.61175976
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.61175976
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60448166
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60448166
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60448166
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59244805
46ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57593529
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.55725107
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54031058
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53430325
50ATF3_27146783_Chip-Seq_COLON_Human1.51806778
51* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49738074
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.48892886
53AR_21909140_ChIP-Seq_LNCAP_Human1.47925009
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47364414
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45957652
56TCF7_22412390_ChIP-Seq_EML_Mouse1.45849994
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44287723
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42634430
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.41100780
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39672011
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39118193
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37254262
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36911553
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36822616
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.35845822
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35273144
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34499515
68KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34492847
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34360174
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.34006035
71* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33928919
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.33604091
73VDR_21846776_ChIP-Seq_THP-1_Human1.33284087
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.33065883
75LXR_22292898_ChIP-Seq_THP-1_Human1.32038904
76ISL1_27105846_Chip-Seq_CPCs_Mouse1.32038145
77* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29914899
78* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29410721
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28314204
80* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26937809
81SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26682499
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24807650
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24631239
84TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24604558
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23321713
86* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21581765
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21566787
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21566787
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21554432
90P68_20966046_ChIP-Seq_HELA_Human1.19521460
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18703631
92SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18038462
93GATA6_25053715_ChIP-Seq_YYC3_Human1.18018794
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17981425
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17586558
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17274087
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16949711
98NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14913318
99UBF1/2_26484160_Chip-Seq_HMECs_Human1.13861094
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13635946
101* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13388404
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13018452
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12889984
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11392154
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10670811
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.09853683
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09782200
108MYC_18358816_ChIP-ChIP_MESCs_Mouse1.09671696
109* SMC4_20622854_ChIP-Seq_HELA_Human1.08305810
110* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07733495
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.07605432
112GATA4_25053715_ChIP-Seq_YYC3_Human1.06644553
113KDM2B_26808549_Chip-Seq_DND41_Human1.06171801
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04869398
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04809917
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04783346
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.04574136
118BRD4_25478319_ChIP-Seq_HGPS_Human1.03958523
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02726532
120XRN2_22483619_ChIP-Seq_HELA_Human1.02310049
121CJUN_26792858_Chip-Seq_BT549_Human1.02257155
122* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02013400
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02001792
124TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01883766
125MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01247827
126CREB1_26743006_Chip-Seq_LNCaP_Human1.00548555
127P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00451709
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00301101
129NCOR1_26117541_ChIP-Seq_K562_Human1.00210339
130* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00159770
131KDM2B_26808549_Chip-Seq_K562_Human0.99113787
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98383678
133* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97958344
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97831714
135KAP1_27257070_Chip-Seq_ESCs_Mouse0.97698573
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97509158
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95506785
138* TP53_22127205_ChIP-Seq_IMR90_Human0.95130959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.00013890
2MP0004272_abnormal_basement_membrane3.31174143
3MP0010368_abnormal_lymphatic_system3.26220758
4MP0008438_abnormal_cutaneous_collagen3.24918077
5MP0005275_abnormal_skin_tensile2.46968575
6MP0010030_abnormal_orbit_morphology2.37920419
7MP0009053_abnormal_anal_canal2.31010172
8MP0004084_abnormal_cardiac_muscle2.17075667
9MP0005257_abnormal_intraocular_pressure2.15434762
10MP0000537_abnormal_urethra_morphology2.08094435
11MP0005360_urolithiasis1.96172847
12MP0003566_abnormal_cell_adhesion1.90600986
13MP0001879_abnormal_lymphatic_vessel1.90442273
14MP0005409_darkened_coat_color1.89237783
15MP0006054_spinal_hemorrhage1.89095137
16MP0003279_aneurysm1.85582200
17MP0005623_abnormal_meninges_morphology1.80994420
18MP0000579_abnormal_nail_morphology1.79153492
19MP0005503_abnormal_tendon_morphology1.76906357
20MP0003941_abnormal_skin_development1.76569423
21MP0004858_abnormal_nervous_system1.71458173
22MP0005501_abnormal_skin_physiology1.70788236
23MP0002139_abnormal_hepatobiliary_system1.68784612
24MP0002877_abnormal_melanocyte_morpholog1.67233065
25MP0010234_abnormal_vibrissa_follicle1.67184207
26MP0000678_abnormal_parathyroid_gland1.66924820
27MP0003385_abnormal_body_wall1.59223831
28MP0002089_abnormal_postnatal_growth/wei1.49657963
29MP0001958_emphysema1.47965392
30MP0006138_congestive_heart_failure1.44559036
31MP0005085_abnormal_gallbladder_physiolo1.43529695
32MP0010352_gastrointestinal_tract_polyps1.42176827
33MP0003567_abnormal_fetal_cardiomyocyte1.41276092
34MP0002837_dystrophic_cardiac_calcinosis1.39911520
35MP0009384_cardiac_valve_regurgitation1.39413715
36MP0000751_myopathy1.37181559
37MP0000767_abnormal_smooth_muscle1.36272601
38MP0003252_abnormal_bile_duct1.34656851
39MP0003115_abnormal_respiratory_system1.34616047
40MP0001849_ear_inflammation1.33487248
41* MP0010630_abnormal_cardiac_muscle1.33120562
42MP0005330_cardiomyopathy1.32634107
43MP0002060_abnormal_skin_morphology1.32324148
44MP0003453_abnormal_keratinocyte_physiol1.31831076
45MP0000733_abnormal_muscle_development1.27343596
46MP0005365_abnormal_bile_salt1.27334033
47MP0000750_abnormal_muscle_regeneration1.26662712
48MP0009672_abnormal_birth_weight1.25537976
49MP0001730_embryonic_growth_arrest1.24681431
50MP0002249_abnormal_larynx_morphology1.23464909
51MP0005167_abnormal_blood-brain_barrier1.22777035
52MP0000534_abnormal_ureter_morphology1.22412065
53MP0003828_pulmonary_edema1.22081830
54MP0003283_abnormal_digestive_organ1.21976670
55MP0004087_abnormal_muscle_fiber1.21250463
56MP0000003_abnormal_adipose_tissue1.20414227
57MP0005023_abnormal_wound_healing1.20290496
58MP0004782_abnormal_surfactant_physiolog1.20183045
59MP0004957_abnormal_blastocyst_morpholog1.19902423
60MP0002282_abnormal_trachea_morphology1.18499866
61MP0003942_abnormal_urinary_system1.18134402
62MP0002085_abnormal_embryonic_tissue1.16571722
63MP0005451_abnormal_body_composition1.14539884
64MP0001544_abnormal_cardiovascular_syste1.11938935
65MP0005385_cardiovascular_system_phenoty1.11938935
66MP0000566_synostosis1.10690926
67MP0005508_abnormal_skeleton_morphology1.10350362
68MP0003123_paternal_imprinting1.10115472
69MP0005076_abnormal_cell_differentiation1.09725302
70MP0000762_abnormal_tongue_morphology1.09015558
71MP0002092_abnormal_eye_morphology1.08601442
72MP0003119_abnormal_digestive_system1.07830405
73MP0002084_abnormal_developmental_patter1.06936717
74MP0002932_abnormal_joint_morphology1.06732427
75MP0003935_abnormal_craniofacial_develop1.06678691
76MP0009250_abnormal_appendicular_skeleto1.05890486
77MP0002796_impaired_skin_barrier1.05394122
78MP0000377_abnormal_hair_follicle1.04727485
79MP0001915_intracranial_hemorrhage1.04392312
80MP0004036_abnormal_muscle_relaxation1.04130838
81MP0008775_abnormal_heart_ventricle1.03636248
82MP0003693_abnormal_embryo_hatching1.03631210
83* MP0002925_abnormal_cardiovascular_devel1.03332504
84MP0002254_reproductive_system_inflammat1.03118456
85MP0005187_abnormal_penis_morphology1.02509683
86MP0005248_abnormal_Harderian_gland1.01749347
87MP0004233_abnormal_muscle_weight1.01485065
88MP0001216_abnormal_epidermal_layer1.01436679
89MP0004215_abnormal_myocardial_fiber1.00624230
90MP0002128_abnormal_blood_circulation1.00488765
91MP0003937_abnormal_limbs/digits/tail_de1.00486866
92MP0008932_abnormal_embryonic_tissue1.00133959
93MP0005666_abnormal_adipose_tissue0.99459030
94MP0009780_abnormal_chondrocyte_physiolo0.99266219
95MP0001661_extended_life_span0.98517187
96MP0002896_abnormal_bone_mineralization0.98348992
97MP0004185_abnormal_adipocyte_glucose0.97986020
98MP0004264_abnormal_extraembryonic_tissu0.97804781
99MP0004197_abnormal_fetal_growth/weight/0.96347400
100MP0000428_abnormal_craniofacial_morphol0.96101776
101* MP0002080_prenatal_lethality0.94577534
102MP0010678_abnormal_skin_adnexa0.92285204
103MP0002108_abnormal_muscle_morphology0.92182619
104* MP0000266_abnormal_heart_morphology0.92120461
105MP0003122_maternal_imprinting0.91712687
106MP0010329_abnormal_lipoprotein_level0.90839430
107MP0002972_abnormal_cardiac_muscle0.90768900
108MP0010771_integument_phenotype0.89796052
109* MP0002088_abnormal_embryonic_growth/wei0.89499684
110* MP0001614_abnormal_blood_vessel0.89251464
111MP0002234_abnormal_pharynx_morphology0.88753872
112* MP0002086_abnormal_extraembryonic_tissu0.88592329
113MP0000432_abnormal_head_morphology0.88223294
114MP0005375_adipose_tissue_phenotype0.88136082
115* MP0003984_embryonic_growth_retardation0.88077981
116MP0001697_abnormal_embryo_size0.87635765
117MP0000462_abnormal_digestive_system0.87273519
118MP0000467_abnormal_esophagus_morphology0.86947870
119MP0003806_abnormal_nucleotide_metabolis0.86876333
120MP0003300_gastrointestinal_ulcer0.85517344
121MP0002116_abnormal_craniofacial_bone0.85198207
122MP0002127_abnormal_cardiovascular_syste0.85175552
123MP0000383_abnormal_hair_follicle0.84097691
124* MP0001672_abnormal_embryogenesis/_devel0.83518671
125* MP0005380_embryogenesis_phenotype0.83518671
126MP0000049_abnormal_middle_ear0.83496280
127MP0003111_abnormal_nucleus_morphology0.82638171
128MP0003091_abnormal_cell_migration0.81928649
129MP0008260_abnormal_autophagy0.81402571
130MP0002697_abnormal_eye_size0.81181715
131MP0002098_abnormal_vibrissa_morphology0.81051335
132MP0002111_abnormal_tail_morphology0.80440549
133MP0002295_abnormal_pulmonary_circulatio0.80205552
134MP0003315_abnormal_perineum_morphology0.79537767
135MP0008875_abnormal_xenobiotic_pharmacok0.79094745
136MP0009931_abnormal_skin_appearance0.78931721
137MP0003755_abnormal_palate_morphology0.78760607

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.98608682
2Premature rupture of membranes (HP:0001788)4.01022964
3Right ventricular cardiomyopathy (HP:0011663)3.90860261
4Shallow orbits (HP:0000586)3.78241760
5Broad metatarsal (HP:0001783)3.73824661
6Increased connective tissue (HP:0009025)3.56282786
7Ankle contracture (HP:0006466)3.51425808
8Hyperacusis (HP:0010780)3.32875343
9Cerebral aneurysm (HP:0004944)3.32467662
10Atrophic scars (HP:0001075)3.24518740
11Lymphangioma (HP:0100764)3.15710906
12Abnormality of the 4th metacarpal (HP:0010012)3.00591003
13Ventricular tachycardia (HP:0004756)2.97955669
14Short 4th metacarpal (HP:0010044)2.92664178
15Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.92664178
16Deep venous thrombosis (HP:0002625)2.88649953
17Aortic dissection (HP:0002647)2.63874347
18Fragile skin (HP:0001030)2.61956334
19Sudden death (HP:0001699)2.59458134
20Mitral valve prolapse (HP:0001634)2.56604473
21Flat acetabular roof (HP:0003180)2.51273392
22Broad face (HP:0000283)2.49208486
23Muscle fiber splitting (HP:0003555)2.48082245
24Aneurysm (HP:0002617)2.45083915
25Bladder diverticulum (HP:0000015)2.44141764
26Aortic aneurysm (HP:0004942)2.43338551
27Type 1 muscle fiber predominance (HP:0003803)2.41567408
28Pterygium (HP:0001059)2.39115979
29Trismus (HP:0000211)2.32495981
30Advanced eruption of teeth (HP:0006288)2.31804822
31Rectal prolapse (HP:0002035)2.30706502
32Spinal rigidity (HP:0003306)2.25499694
33Arterial tortuosity (HP:0005116)2.25306345
34Esophageal varix (HP:0002040)2.22432769
35Wrist flexion contracture (HP:0001239)2.21045175
36Mildly elevated creatine phosphokinase (HP:0008180)2.20728533
37Ulnar bowing (HP:0003031)2.19534340
38Short nail (HP:0001799)2.15359438
39Arnold-Chiari malformation (HP:0002308)2.12112847
40Hyporeflexia of lower limbs (HP:0002600)2.11932406
41Renal duplication (HP:0000075)2.11745870
42Blue sclerae (HP:0000592)2.11577684
43Milia (HP:0001056)2.10895350
44Vascular tortuosity (HP:0004948)2.06394698
45Peritonitis (HP:0002586)2.06224469
46Fragile nails (HP:0001808)2.06146085
47Abnormal vertebral ossification (HP:0100569)2.05022327
48Septate vagina (HP:0001153)2.05021568
49Wide anterior fontanel (HP:0000260)2.04402003
50Lipoatrophy (HP:0100578)2.03494062
51Asymmetry of the thorax (HP:0001555)2.02871350
52Soft skin (HP:0000977)2.01725977
53Natal tooth (HP:0000695)2.01182280
54Coronal craniosynostosis (HP:0004440)2.00689604
55Ankyloglossia (HP:0010296)1.99052756
56Neonatal death (HP:0003811)1.99051649
57Polycythemia (HP:0001901)1.98382384
58Aplasia involving bones of the upper limbs (HP:0009823)1.98216678
59Aplasia of the phalanges of the hand (HP:0009802)1.98216678
60Aplasia involving bones of the extremities (HP:0009825)1.98216678
61Insomnia (HP:0100785)1.96031016
62Thin bony cortex (HP:0002753)1.95955337
63Turricephaly (HP:0000262)1.95598819
64J-shaped sella turcica (HP:0002680)1.95550545
65Abnormality of the distal phalanges of the toes (HP:0010182)1.95509376
66Distal lower limb amyotrophy (HP:0008944)1.95050898
67Distal lower limb muscle weakness (HP:0009053)1.94235037
68Difficulty climbing stairs (HP:0003551)1.94066587
69Biconcave vertebral bodies (HP:0004586)1.93735377
70Dilatation of the ascending aorta (HP:0005111)1.93054037
71Hypoplastic ischia (HP:0003175)1.91739694
72Hematochezia (HP:0002573)1.91463570
73Deviation of the thumb (HP:0009603)1.91069235
74Overriding aorta (HP:0002623)1.90847372
75Camptodactyly of toe (HP:0001836)1.90203166
76Increased variability in muscle fiber diameter (HP:0003557)1.87120420
77Abnormality of oral frenula (HP:0000190)1.87103839
78Hemorrhage of the eye (HP:0011885)1.86495235
79Nonimmune hydrops fetalis (HP:0001790)1.85667181
80Deviation of the hallux (HP:0010051)1.84900475
81Neonatal short-limb short stature (HP:0008921)1.84757212
82Visceral angiomatosis (HP:0100761)1.83550340
83Upper limb amyotrophy (HP:0009129)1.83430892
84Distal upper limb amyotrophy (HP:0007149)1.83430892
85Vertebral compression fractures (HP:0002953)1.81695254
86Renovascular hypertension (HP:0100817)1.80544896
87Elfin facies (HP:0004428)1.79345747
88Xanthomatosis (HP:0000991)1.78544048
89Abnormal ossification of hand bones (HP:0005921)1.78183667
90Cervical subluxation (HP:0003308)1.77630352
91Premature skin wrinkling (HP:0100678)1.76841321
92Exercise-induced muscle cramps (HP:0003710)1.76827566
93Achilles tendon contracture (HP:0001771)1.76512274
94Short hallux (HP:0010109)1.76119331
95Microglossia (HP:0000171)1.76042132
96Intrahepatic cholestasis (HP:0001406)1.75070042
97Abnormality of the acetabulum (HP:0003170)1.74855847
98Abnormality of dentin (HP:0010299)1.74627847
99Long toe (HP:0010511)1.74543316
100Spinal cord compression (HP:0002176)1.73777786
101Hemangiomatosis (HP:0007461)1.71783593
102Ectopia lentis (HP:0001083)1.71380104
103Hallux valgus (HP:0001822)1.71133373
104Abnormality of the ischium (HP:0003174)1.70870819
105Broad toe (HP:0001837)1.70754429
106Patellar dislocation (HP:0002999)1.70386490
107Skull defect (HP:0001362)1.69306641
108Selective tooth agenesis (HP:0001592)1.69213394
109Hypoalphalipoproteinemia (HP:0003233)1.69141323
110Thin ribs (HP:0000883)1.68862762
111Alopecia of scalp (HP:0002293)1.67496815
112Abnormal cartilage morphology (HP:0002763)1.66842440
113Back pain (HP:0003418)1.66629679
114Abnormality of carpal bone ossification (HP:0006257)1.66335623
115Buphthalmos (HP:0000557)1.66325578
116Disproportionate tall stature (HP:0001519)1.65576974
117Atrial fibrillation (HP:0005110)1.65410328
118Mesangial abnormality (HP:0001966)1.65161552
119Abnormality of monocarboxylic acid metabolism (HP:0010996)1.65079020
120Overgrowth (HP:0001548)1.64693401
121Stridor (HP:0010307)1.64645517
122Abnormality of the distal phalanx of the thumb (HP:0009617)1.64624066
123Hip contracture (HP:0003273)1.64542705
124Aplasia/Hypoplasia of the hallux (HP:0008362)1.64470753
125Bronchomalacia (HP:0002780)1.64366612
126Joint laxity (HP:0001388)1.63263874
127Follicular hyperkeratosis (HP:0007502)1.63020787
128Long palpebral fissure (HP:0000637)1.62986635
129Germ cell neoplasia (HP:0100728)1.62796686
130Abnormality of the umbilical cord (HP:0010881)1.62600913
131Capillary hemangiomas (HP:0005306)1.62239642
132Abnormality of the Achilles tendon (HP:0005109)1.62209602
133Congenital glaucoma (HP:0001087)1.61047750
134Tracheal stenosis (HP:0002777)1.60758658
135Midface retrusion (HP:0011800)1.60320218
136Proximal placement of thumb (HP:0009623)1.60249984
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60226812
138Genu recurvatum (HP:0002816)1.60150262
139Bowing of the arm (HP:0006488)1.59254680
140Bowed forearm bones (HP:0003956)1.59254680
141Hypoglycemic coma (HP:0001325)1.58923705
142Subacute progressive viral hepatitis (HP:0006572)1.58919112
143Abnormality of skeletal muscle fiber size (HP:0012084)1.58807640
144Scapular winging (HP:0003691)1.58469312
145Broad distal phalanx of finger (HP:0009836)1.58458054
146Myoglobinuria (HP:0002913)1.58040007
147Venous abnormality (HP:0002624)1.56833624
148Supraventricular arrhythmia (HP:0005115)1.56450546
149Mesomelia (HP:0003027)1.56126932
150Wormian bones (HP:0002645)1.55997381
151Vertebral clefting (HP:0008428)1.55528902
152Enlarged penis (HP:0000040)1.54690109
153High anterior hairline (HP:0009890)1.54673446
154Spastic diplegia (HP:0001264)1.54502932
155Knee flexion contracture (HP:0006380)1.54197952
156Shawl scrotum (HP:0000049)1.53478810
157Pseudobulbar signs (HP:0002200)1.53033689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.92300358
2TIE13.90060925
3TRIB33.86985050
4PKN23.41394109
5LATS13.32603731
6TTN3.28621704
7KDR2.67256313
8PDGFRA2.55802050
9RIPK12.45889101
10EPHB22.41175932
11DDR22.24775191
12SIK12.23715119
13ERN12.18801000
14PTK62.07549730
15LATS22.06907108
16MAP3K102.06179864
17EPHA22.05581314
18IRAK32.01391870
19TGFBR21.99939332
20STK38L1.69838083
21TGFBR11.69656276
22PAK41.68831021
23LMTK21.68503086
24NTRK11.55201950
25FER1.54375878
26CDK121.50609302
27BCKDK1.45505006
28PTK21.44718880
29EEF2K1.43879838
30FGFR41.41515916
31DMPK1.39473547
32MET1.38678682
33MYLK1.23810474
34ICK1.22992176
35LRRK21.19586324
36NME21.19251813
37STK31.17353225
38BMX1.15404337
39MTOR1.13305618
40PAK21.10132317
41NEK11.09234627
42VRK21.08445624
43FLT31.01199948
44FGFR11.00995057
45RPS6KA20.98557500
46RPS6KB20.96478410
47EPHA30.92327508
48CDK60.90355924
49MAP3K30.88990372
50FGFR20.85652498
51ILK0.84607869
52MST1R0.84493907
53CAMK1D0.81384203
54WNK40.81045161
55ERBB20.79780252
56PDGFRB0.78559938
57EPHB10.78351284
58PDK40.76439712
59PDK30.76439712
60PIK3CA0.76110475
61TAF10.75754187
62PTK2B0.71931623
63MAP2K20.71582376
64STK100.71151459
65MAP2K30.70772719
66TESK10.70754107
67PRKD10.69177161
68PAK30.67517407
69MUSK0.66900402
70PRPF4B0.66528609
71NEK90.66424066
72MAP3K80.64586947
73PRKD20.64009267
74MAP3K70.61186492
75NEK20.60972845
76CDK40.59034043
77RPS6KL10.58677228
78RPS6KC10.58677228
79PRKG20.58616934
80ROCK10.58188546
81TTK0.57949475
82PDK20.56432675
83CDK80.56170485
84MAP3K60.53997245
85DYRK1B0.53189408
86AKT20.51383250
87CHEK20.49884774
88CDK70.49717727
89TYRO30.49517235
90OBSCN0.49489393
91PDPK10.48452507
92GSK3A0.46393120
93PRKAA20.45347490
94RPS6KA40.45025971
95MAP2K10.44219242
96CAMK1G0.44215521
97MAPKAPK30.43759489
98PRKCI0.43537715
99PRKD30.43486417
100CDC42BPA0.41129381
101CDK90.40619224
102RET0.40036354
103MELK0.39874035
104AURKA0.39010951
105RPS6KA60.39002795
106TRPM70.38312753
107STK40.37577589
108ERBB40.37475831
109SCYL20.36346813
110STK380.36299383
111PHKG20.35791619
112PHKG10.35791619
113MAP3K90.34913569
114IRAK20.34827604
115MAP3K110.34497949
116MAPK110.34336604
117BRAF0.34146472
118KSR20.33630896
119FGFR30.33477359
120CLK10.31997169
121CHEK10.30472519
122MARK20.29950650
123NME10.28657423
124SRC0.28285908
125AURKB0.28195618
126FRK0.27745537
127CAMK40.26788783
128MAP3K10.26756719
129MATK0.26492442
130BRD40.26377763
131MAPKAPK20.25611295
132RPS6KA10.25093068
133MAPK10.25090020
134HIPK20.24804975
135BUB10.24418386
136PBK0.23943388

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.63040876
2Fatty acid degradation_Homo sapiens_hsa000712.57833080
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50589950
4ECM-receptor interaction_Homo sapiens_hsa045122.45620872
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.37038282
6Nitrogen metabolism_Homo sapiens_hsa009102.25123351
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21199911
8Arginine biosynthesis_Homo sapiens_hsa002202.05849004
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03109816
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98302150
11Adherens junction_Homo sapiens_hsa045201.92635998
12Tryptophan metabolism_Homo sapiens_hsa003801.89596825
13Basal cell carcinoma_Homo sapiens_hsa052171.88661828
14Fatty acid metabolism_Homo sapiens_hsa012121.85432605
15Propanoate metabolism_Homo sapiens_hsa006401.84137679
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.83716858
17Focal adhesion_Homo sapiens_hsa045101.75626141
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72998035
19PPAR signaling pathway_Homo sapiens_hsa033201.71931233
20Lysine degradation_Homo sapiens_hsa003101.63817615
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59692694
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57614375
23Carbon metabolism_Homo sapiens_hsa012001.55762367
24Protein digestion and absorption_Homo sapiens_hsa049741.55331904
25Pentose phosphate pathway_Homo sapiens_hsa000301.53628683
26Hippo signaling pathway_Homo sapiens_hsa043901.52658417
27Complement and coagulation cascades_Homo sapiens_hsa046101.48436731
28Small cell lung cancer_Homo sapiens_hsa052221.42212284
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41376776
30Dilated cardiomyopathy_Homo sapiens_hsa054141.41321971
31Proteoglycans in cancer_Homo sapiens_hsa052051.38543772
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.37059943
33Pyruvate metabolism_Homo sapiens_hsa006201.33184138
34Bladder cancer_Homo sapiens_hsa052191.32549390
35Biosynthesis of amino acids_Homo sapiens_hsa012301.31246928
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30416857
37Butanoate metabolism_Homo sapiens_hsa006501.28933465
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28897753
39Fat digestion and absorption_Homo sapiens_hsa049751.28335128
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27918672
41Bile secretion_Homo sapiens_hsa049761.27045575
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26883778
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26192838
44Tight junction_Homo sapiens_hsa045301.26095581
45Hedgehog signaling pathway_Homo sapiens_hsa043401.24281768
46N-Glycan biosynthesis_Homo sapiens_hsa005101.22437910
47Selenocompound metabolism_Homo sapiens_hsa004501.21320525
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16384077
49VEGF signaling pathway_Homo sapiens_hsa043701.16099372
50DNA replication_Homo sapiens_hsa030301.14782106
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.14146349
52Fructose and mannose metabolism_Homo sapiens_hsa000511.13154882
53Vitamin B6 metabolism_Homo sapiens_hsa007501.12748218
54Amoebiasis_Homo sapiens_hsa051461.10293828
55Non-small cell lung cancer_Homo sapiens_hsa052231.09079059
56TGF-beta signaling pathway_Homo sapiens_hsa043501.08699922
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06378633
58Caffeine metabolism_Homo sapiens_hsa002321.05814389
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03871369
60Chemical carcinogenesis_Homo sapiens_hsa052041.03089940
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02342767
62beta-Alanine metabolism_Homo sapiens_hsa004101.02308169
63Acute myeloid leukemia_Homo sapiens_hsa052211.02139204
64Notch signaling pathway_Homo sapiens_hsa043301.01824224
65Pancreatic cancer_Homo sapiens_hsa052120.99210801
66ErbB signaling pathway_Homo sapiens_hsa040120.98560721
67Glioma_Homo sapiens_hsa052140.98161626
68Starch and sucrose metabolism_Homo sapiens_hsa005000.95742126
69Arginine and proline metabolism_Homo sapiens_hsa003300.95103325
70Insulin resistance_Homo sapiens_hsa049310.95074183
71Prion diseases_Homo sapiens_hsa050200.93942892
72* Axon guidance_Homo sapiens_hsa043600.93736597
73Phenylalanine metabolism_Homo sapiens_hsa003600.93172190
74MicroRNAs in cancer_Homo sapiens_hsa052060.91690396
75Other glycan degradation_Homo sapiens_hsa005110.90420923
76Renal cell carcinoma_Homo sapiens_hsa052110.88194993
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86389597
78Viral myocarditis_Homo sapiens_hsa054160.85683140
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84037124
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.82924217
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.82583019
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81648057
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.80974888
84Colorectal cancer_Homo sapiens_hsa052100.79087584
85Cell cycle_Homo sapiens_hsa041100.78957842
86Base excision repair_Homo sapiens_hsa034100.78949514
87Peroxisome_Homo sapiens_hsa041460.78781689
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78693499
89Fatty acid biosynthesis_Homo sapiens_hsa000610.77982669
90Retinol metabolism_Homo sapiens_hsa008300.77659511
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77256071
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75965849
93Melanogenesis_Homo sapiens_hsa049160.73332432
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72921544
95mRNA surveillance pathway_Homo sapiens_hsa030150.72494999
96Tyrosine metabolism_Homo sapiens_hsa003500.71462648
97Thyroid cancer_Homo sapiens_hsa052160.71337971
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71315043
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.70182150
100Histidine metabolism_Homo sapiens_hsa003400.70154320
101p53 signaling pathway_Homo sapiens_hsa041150.68600414
102AMPK signaling pathway_Homo sapiens_hsa041520.67582474
103Inositol phosphate metabolism_Homo sapiens_hsa005620.67407611
104Pathways in cancer_Homo sapiens_hsa052000.66756089
105Steroid biosynthesis_Homo sapiens_hsa001000.65565051
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.64709307
107Choline metabolism in cancer_Homo sapiens_hsa052310.62983146
108Estrogen signaling pathway_Homo sapiens_hsa049150.62346415
109One carbon pool by folate_Homo sapiens_hsa006700.61870616
110Chronic myeloid leukemia_Homo sapiens_hsa052200.60293644
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60224636
112RNA transport_Homo sapiens_hsa030130.59152155
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.58554728
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.58216242
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53087591
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.52806215
117Glutathione metabolism_Homo sapiens_hsa004800.51935807
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.50844787
119Rap1 signaling pathway_Homo sapiens_hsa040150.50644136
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50539300
121Melanoma_Homo sapiens_hsa052180.50187285
122Viral carcinogenesis_Homo sapiens_hsa052030.48214493
123Endometrial cancer_Homo sapiens_hsa052130.48097989
124Sulfur metabolism_Homo sapiens_hsa009200.47304092
125Wnt signaling pathway_Homo sapiens_hsa043100.47179472
126Prostate cancer_Homo sapiens_hsa052150.46697305
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45514303
128Glucagon signaling pathway_Homo sapiens_hsa049220.44562027
129Insulin signaling pathway_Homo sapiens_hsa049100.43657699
130HIF-1 signaling pathway_Homo sapiens_hsa040660.42595745
131HTLV-I infection_Homo sapiens_hsa051660.42186339
132Vitamin digestion and absorption_Homo sapiens_hsa049770.42083822
133Sulfur relay system_Homo sapiens_hsa041220.40635236
134Galactose metabolism_Homo sapiens_hsa000520.40336060
135Fatty acid elongation_Homo sapiens_hsa000620.40062689
136Glycerolipid metabolism_Homo sapiens_hsa005610.39125998
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39048214
138mTOR signaling pathway_Homo sapiens_hsa041500.38985716
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38813837

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