EPHB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.97496221
2synaptic vesicle maturation (GO:0016188)5.77086814
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45868929
4locomotory exploration behavior (GO:0035641)5.37176770
5synaptic vesicle exocytosis (GO:0016079)5.18864957
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.18651959
7glutamate secretion (GO:0014047)5.17512112
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16333333
9vocalization behavior (GO:0071625)5.14399450
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.06051504
11L-amino acid import (GO:0043092)5.04760276
12cerebellar granule cell differentiation (GO:0021707)4.94575172
13regulation of ARF protein signal transduction (GO:0032012)4.75302135
14regulation of synaptic vesicle exocytosis (GO:2000300)4.72278597
15regulation of glutamate receptor signaling pathway (GO:1900449)4.65382653
16protein localization to synapse (GO:0035418)4.59379487
17layer formation in cerebral cortex (GO:0021819)4.56328861
18dendritic spine morphogenesis (GO:0060997)4.47662965
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44501656
20regulation of neuronal synaptic plasticity (GO:0048168)4.44484502
21exploration behavior (GO:0035640)4.34131140
22amino acid import (GO:0043090)4.32765733
23neuronal action potential propagation (GO:0019227)4.28258775
24desmosome organization (GO:0002934)4.27570688
25regulation of synapse structural plasticity (GO:0051823)4.18694407
26regulation of synaptic vesicle transport (GO:1902803)4.18459145
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.13616464
28neurotransmitter secretion (GO:0007269)4.01889624
29neuron cell-cell adhesion (GO:0007158)3.93064130
30axon ensheathment in central nervous system (GO:0032291)3.90068808
31central nervous system myelination (GO:0022010)3.90068808
32regulation of synapse maturation (GO:0090128)3.82875331
33potassium ion homeostasis (GO:0055075)3.78742129
34proline transport (GO:0015824)3.77290758
35negative regulation of dendrite morphogenesis (GO:0050774)3.77119968
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.76796352
37glutamate receptor signaling pathway (GO:0007215)3.74703841
38regulation of dendritic spine morphogenesis (GO:0061001)3.73569367
39synaptic transmission, glutamatergic (GO:0035249)3.72980318
40neurotransmitter-gated ion channel clustering (GO:0072578)3.72570771
41negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.69247668
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67074986
43positive regulation of dendritic spine morphogenesis (GO:0061003)3.59022623
44positive regulation of membrane potential (GO:0045838)3.58223743
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.54384415
46neuron-neuron synaptic transmission (GO:0007270)3.53609779
47regulation of synaptic plasticity (GO:0048167)3.53287271
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.52550871
49long-term memory (GO:0007616)3.50757494
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.47537876
51dendritic spine organization (GO:0097061)3.47516039
52cellular potassium ion homeostasis (GO:0030007)3.45582450
53positive regulation of synapse maturation (GO:0090129)3.45023498
54axonal fasciculation (GO:0007413)3.43451001
55positive regulation of neurotransmitter secretion (GO:0001956)3.42785480
56regulation of vesicle fusion (GO:0031338)3.40753344
57neuron recognition (GO:0008038)3.40600765
58sodium ion export (GO:0071436)3.37477635
59regulation of postsynaptic membrane potential (GO:0060078)3.36444766
60potassium ion import (GO:0010107)3.35030210
61activation of protein kinase A activity (GO:0034199)3.30671608
62positive regulation of neurotransmitter transport (GO:0051590)3.30653193
63signal complex assembly (GO:0007172)3.30128584
64regulation of dendritic spine development (GO:0060998)3.28023961
65auditory behavior (GO:0031223)3.25234515
66long-term synaptic potentiation (GO:0060291)3.24879133
67neuromuscular process controlling balance (GO:0050885)3.22812591
68vesicle docking involved in exocytosis (GO:0006904)3.21156430
69cell communication by electrical coupling (GO:0010644)3.19730705
70regulation of clathrin-mediated endocytosis (GO:2000369)3.18687961
71postsynaptic membrane organization (GO:0001941)3.17446075
72positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17137631
73regulation of neurotransmitter secretion (GO:0046928)3.14646346
74negative regulation of erythrocyte differentiation (GO:0045647)3.14565580
75positive regulation of vesicle fusion (GO:0031340)3.14013014
76cell differentiation in hindbrain (GO:0021533)3.12822578
77sleep (GO:0030431)3.12007965
78neurotransmitter transport (GO:0006836)3.10884852
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09924888
80cerebellar Purkinje cell differentiation (GO:0021702)3.09095323
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08998820
82synaptic vesicle endocytosis (GO:0048488)3.08805610
83dendrite morphogenesis (GO:0048813)3.08344982
84regulation of exocytosis (GO:0017157)3.04767888
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.03479257
86gamma-aminobutyric acid transport (GO:0015812)2.99603463
87positive regulation of Rap GTPase activity (GO:0032854)2.99318781
88chemosensory behavior (GO:0007635)2.98560835
89cell migration in hindbrain (GO:0021535)2.98032892
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.97394886
91neuromuscular process controlling posture (GO:0050884)2.97074243
92response to auditory stimulus (GO:0010996)2.94718483
93prepulse inhibition (GO:0060134)2.93533290
94vesicle transport along microtubule (GO:0047496)2.91457669
95regulation of neurotransmitter transport (GO:0051588)2.91249418
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91107823
97innervation (GO:0060384)2.89053844
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88003214
99social behavior (GO:0035176)2.87464477
100intraspecies interaction between organisms (GO:0051703)2.87464477
101transmission of nerve impulse (GO:0019226)2.87350312
102neuronal ion channel clustering (GO:0045161)2.86839174
103cellular sodium ion homeostasis (GO:0006883)2.86168491
104positive regulation of synaptic transmission (GO:0050806)2.85652950
105regulation of neurotransmitter levels (GO:0001505)2.84897521
106membrane depolarization (GO:0051899)2.84874627
107learning (GO:0007612)2.84600759
108vesicle docking (GO:0048278)2.83862982
109positive regulation of dendritic spine development (GO:0060999)2.82563864
110phosphorelay signal transduction system (GO:0000160)2.82502819
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.81710841
112synaptic vesicle transport (GO:0048489)2.80455816
113establishment of synaptic vesicle localization (GO:0097480)2.80455816
114negative regulation of synaptic transmission, GABAergic (GO:0032229)2.79900252
115acidic amino acid transport (GO:0015800)2.79791995
116establishment of nucleus localization (GO:0040023)2.79232127
117regulation of synaptic transmission (GO:0050804)2.78872012
118behavioral response to cocaine (GO:0048148)2.78373726
119regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.76645581
120central nervous system projection neuron axonogenesis (GO:0021952)2.76465664
121synapse assembly (GO:0007416)2.76274925
122response to histamine (GO:0034776)2.75849055
123establishment of skin barrier (GO:0061436)2.75375543
124regulation of ARF GTPase activity (GO:0032312)2.75147118
125negative regulation of dendrite development (GO:2000171)2.74099706
126synaptic transmission (GO:0007268)2.73816850
127membrane depolarization during action potential (GO:0086010)2.73758391
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.73664906
129peptidyl-tyrosine autophosphorylation (GO:0038083)2.72940100
130positive regulation of dendrite development (GO:1900006)2.72665251
131glycine transport (GO:0015816)2.69891670
132synapse organization (GO:0050808)2.68447564
133regulation of voltage-gated calcium channel activity (GO:1901385)2.67842062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96463132
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.33245943
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05471819
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02102510
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97008081
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.80483423
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.80483423
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72226203
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62095075
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59930913
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.58704941
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.53120374
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50957495
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45041650
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.44655758
16GBX2_23144817_ChIP-Seq_PC3_Human2.44510838
17* RARB_27405468_Chip-Seq_BRAIN_Mouse2.43567357
18DROSHA_22980978_ChIP-Seq_HELA_Human2.42645855
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.33677075
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31969485
21REST_21632747_ChIP-Seq_MESCs_Mouse2.25027686
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.24422782
23KDM2B_26808549_Chip-Seq_DND41_Human2.23774853
24AR_21572438_ChIP-Seq_LNCaP_Human2.16665395
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15000018
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01222775
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96944020
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95358485
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90200003
30TCF7_22412390_ChIP-Seq_EML_Mouse1.86785838
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.85092392
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.84348079
33SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61469157
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58059984
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57454377
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55746145
37SMC4_20622854_ChIP-Seq_HELA_Human1.55260767
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52836379
39P68_20966046_ChIP-Seq_HELA_Human1.52306919
40VDR_21846776_ChIP-Seq_THP-1_Human1.49670738
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47324159
42CREB1_26743006_Chip-Seq_LNCaP_Human1.46392500
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.44796303
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44579144
45KDM2B_26808549_Chip-Seq_K562_Human1.44326406
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42520607
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38888700
48SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34933543
49MYC_22102868_ChIP-Seq_BL_Human1.34693854
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.32893776
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32332029
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31308916
53ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30824422
54OCT4_19829295_ChIP-Seq_ESCs_Human1.29021125
55SCL_19346495_ChIP-Seq_HPC-7_Human1.28072504
56WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27445608
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26952333
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.23868224
59SMAD4_21799915_ChIP-Seq_A2780_Human1.23735522
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22296557
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22100944
62* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20126748
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19958503
64* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19720928
65AHR_22903824_ChIP-Seq_MCF-7_Human1.19626890
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19318966
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19305409
68RACK7_27058665_Chip-Seq_MCF-7_Human1.18666303
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18052855
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18019676
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.15920385
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15404520
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15055809
74EGR1_19032775_ChIP-ChIP_M12_Human1.14816951
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14608655
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.14572006
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14235824
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13452383
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13429417
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12575445
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.11621808
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.10879670
83GATA1_19941826_ChIP-Seq_K562_Human1.10393964
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.10204771
85KLF4_19829295_ChIP-Seq_ESCs_Human1.09306569
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.09238152
87CTCF_27219007_Chip-Seq_Bcells_Human1.08495495
88AR_19668381_ChIP-Seq_PC3_Human1.08370518
89AR_25329375_ChIP-Seq_VCAP_Human1.07754002
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07659094
91RXR_22108803_ChIP-Seq_LS180_Human1.07620447
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.06939928
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06689240
94ZNF263_19887448_ChIP-Seq_K562_Human1.06153599
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.06134864
96TAF15_26573619_Chip-Seq_HEK293_Human1.05434470
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05367627
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.05149537
99RUNX_20019798_ChIP-Seq_JUKART_Human1.04718657
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04269757
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03887163
102TP53_16413492_ChIP-PET_HCT116_Human1.03123327
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02915068
104TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02837930
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.02071397
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01288257
107ELF1_20517297_ChIP-Seq_JURKAT_Human1.01108924
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.00223386
109TP53_18474530_ChIP-ChIP_U2OS_Human0.99240861
110ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98731580
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98381282
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98310561
113DPY_21335234_ChIP-Seq_ESCs_Mouse0.97675307
114* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97602688
115GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97369906
116SMAD3_21741376_ChIP-Seq_ESCs_Human0.97011309
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96036268
118ZNF274_21170338_ChIP-Seq_K562_Hela0.95764066
119UTX_26944678_Chip-Seq_JUKART_Human0.95752601
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95496418
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95284551
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95104266
123VDR_24763502_ChIP-Seq_THP-1_Human0.94932639
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94485898
125SPI1_23127762_ChIP-Seq_K562_Human0.94390092
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94365208
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94317984
128SA1_27219007_Chip-Seq_Bcells_Human0.93941281
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.92576236
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92161336
131ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91985409
132SMAD4_21741376_ChIP-Seq_ESCs_Human0.91954384
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91585755
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91029356
135RNF2_27304074_Chip-Seq_NSC_Mouse0.90265276
136SMAD4_21741376_ChIP-Seq_HESCs_Human0.90245371
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90000844
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89786515
139TET1_21490601_ChIP-Seq_MESCs_Mouse0.89323311
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88553108
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87708070
142P300_19829295_ChIP-Seq_ESCs_Human0.87309218
143BCAT_22108803_ChIP-Seq_LS180_Human0.86388021
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86374848
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.85668256
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85618721
147LXR_22292898_ChIP-Seq_THP-1_Human0.84848621
148PRDM14_20953172_ChIP-Seq_ESCs_Human0.84187878
149STAT3_23295773_ChIP-Seq_U87_Human0.81647931
150THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79912777
151TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78287327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.71818071
2MP0003880_abnormal_central_pattern4.35097438
3MP0003635_abnormal_synaptic_transmissio3.97463652
4MP0004270_analgesia3.63198412
5MP0002063_abnormal_learning/memory/cond3.21922117
6MP0009745_abnormal_behavioral_response3.04796279
7MP0010234_abnormal_vibrissa_follicle2.95405491
8MP0002064_seizures2.80543455
9MP0001968_abnormal_touch/_nociception2.77361329
10MP0002822_catalepsy2.74583263
11MP0002796_impaired_skin_barrier2.60441405
12MP0009046_muscle_twitch2.52607894
13MP0002572_abnormal_emotion/affect_behav2.51767990
14MP0001486_abnormal_startle_reflex2.41692489
15MP0005423_abnormal_somatic_nervous2.33512258
16MP0009780_abnormal_chondrocyte_physiolo2.32381313
17MP0002734_abnormal_mechanical_nocicepti2.29839187
18MP0002272_abnormal_nervous_system2.11392789
19MP0004858_abnormal_nervous_system2.05064098
20MP0003329_amyloid_beta_deposits2.03484399
21MP0001501_abnormal_sleep_pattern2.03203469
22MP0008569_lethality_at_weaning1.98080521
23MP0002736_abnormal_nociception_after1.96389267
24MP0003690_abnormal_glial_cell1.94795266
25MP0000920_abnormal_myelination1.82842260
26MP0002733_abnormal_thermal_nociception1.77828529
27MP0001440_abnormal_grooming_behavior1.77107867
28MP0005275_abnormal_skin_tensile1.76737089
29MP0000778_abnormal_nervous_system1.73119879
30MP0004811_abnormal_neuron_physiology1.72196407
31MP0001970_abnormal_pain_threshold1.70745006
32MP0002184_abnormal_innervation1.69759505
33MP0002735_abnormal_chemical_nociception1.64859779
34MP0003879_abnormal_hair_cell1.60090631
35MP0000579_abnormal_nail_morphology1.59813573
36MP0002909_abnormal_adrenal_gland1.58024772
37MP0002067_abnormal_sensory_capabilities1.55561717
38* MP0002557_abnormal_social/conspecific_i1.53309697
39MP0001984_abnormal_olfaction1.44746421
40MP0003941_abnormal_skin_development1.43223122
41MP0000955_abnormal_spinal_cord1.40221061
42MP0008961_abnormal_basal_metabolism1.38040331
43MP0004924_abnormal_behavior1.37067283
44MP0005386_behavior/neurological_phenoty1.37067283
45MP0003172_abnormal_lysosome_physiology1.36206320
46MP0004885_abnormal_endolymph1.31685105
47MP0005501_abnormal_skin_physiology1.29846236
48MP0003787_abnormal_imprinting1.29333718
49MP0002882_abnormal_neuron_morphology1.26530486
50MP0003763_abnormal_thymus_physiology1.25940092
51MP0010771_integument_phenotype1.22968151
52MP0000751_myopathy1.19170819
53MP0002066_abnormal_motor_capabilities/c1.16627887
54MP0003633_abnormal_nervous_system1.15181161
55MP0002254_reproductive_system_inflammat1.14111667
56MP0010678_abnormal_skin_adnexa1.12697501
57MP0005646_abnormal_pituitary_gland1.07183725
58MP0003123_paternal_imprinting1.07014903
59MP0002234_abnormal_pharynx_morphology1.05254101
60MP0009379_abnormal_foot_pigmentation1.03810557
61MP0006276_abnormal_autonomic_nervous1.00236125
62MP0009278_abnormal_bone_marrow0.98939787
63MP0001502_abnormal_circadian_rhythm0.98098937
64* MP0004947_skin_inflammation0.96842408
65MP0001177_atelectasis0.95422424
66MP0001188_hyperpigmentation0.95199085
67MP0002152_abnormal_brain_morphology0.94994865
68MP0003631_nervous_system_phenotype0.94876859
69MP0001348_abnormal_lacrimal_gland0.92854069
70MP0005535_abnormal_body_temperature0.92627350
71MP0008874_decreased_physiological_sensi0.91215249
72MP0005623_abnormal_meninges_morphology0.90992206
73MP0002229_neurodegeneration0.88244146
74MP0001529_abnormal_vocalization0.87190833
75MP0001216_abnormal_epidermal_layer0.86298839
76MP0000013_abnormal_adipose_tissue0.85953226
77MP0000467_abnormal_esophagus_morphology0.83747521
78MP0000383_abnormal_hair_follicle0.83477277
79MP0002069_abnormal_eating/drinking_beha0.82495259
80MP0000647_abnormal_sebaceous_gland0.82042585
81MP0004130_abnormal_muscle_cell0.80665882
82MP0000427_abnormal_hair_cycle0.80446078
83MP0003075_altered_response_to0.80216463
84MP0005409_darkened_coat_color0.80049951
85MP0005645_abnormal_hypothalamus_physiol0.78547913
86MP0001905_abnormal_dopamine_level0.77922138
87MP0001346_abnormal_lacrimal_gland0.77891738
88MP0001963_abnormal_hearing_physiology0.76089418
89MP0010386_abnormal_urinary_bladder0.75833426
90MP0004742_abnormal_vestibular_system0.75797980
91MP0004142_abnormal_muscle_tone0.75315701
92MP0000604_amyloidosis0.74864237
93MP0003122_maternal_imprinting0.74377516
94MP0002060_abnormal_skin_morphology0.73778931
95MP0005394_taste/olfaction_phenotype0.72805190
96MP0005499_abnormal_olfactory_system0.72805190
97MP0001849_ear_inflammation0.72422675
98MP0000681_abnormal_thyroid_gland0.72416357
99MP0001299_abnormal_eye_distance/0.71112185
100MP0003183_abnormal_peptide_metabolism0.68402304
101MP0005187_abnormal_penis_morphology0.68323143
102MP0003436_decreased_susceptibility_to0.68212077
103MP0008872_abnormal_physiological_respon0.67200242
104MP0005166_decreased_susceptibility_to0.66973748
105MP0002090_abnormal_vision0.66473109
106MP0002098_abnormal_vibrissa_morphology0.66353807
107MP0001851_eye_inflammation0.65161739
108MP0004381_abnormal_hair_follicle0.63630954
109MP0001986_abnormal_taste_sensitivity0.63391187
110MP0000631_abnormal_neuroendocrine_gland0.62551400
111MP0002133_abnormal_respiratory_system0.62258266
112MP0005388_respiratory_system_phenotype0.62258266
113MP0003632_abnormal_nervous_system0.60942578
114MP0003634_abnormal_glial_cell0.60716653
115MP0003191_abnormal_cellular_cholesterol0.60304801
116MP0001340_abnormal_eyelid_morphology0.59437497
117MP0004145_abnormal_muscle_electrophysio0.59272081
118MP0008260_abnormal_autophagy0.58762071
119MP0003705_abnormal_hypodermis_morpholog0.58164242
120MP0003045_fibrosis0.57955897
121MP0002396_abnormal_hematopoietic_system0.57342931
122MP0000703_abnormal_thymus_morphology0.57320439
123MP0004085_abnormal_heartbeat0.56581765
124MP0002752_abnormal_somatic_nervous0.56185220
125MP0002249_abnormal_larynx_morphology0.55476011
126MP0004510_myositis0.55459263
127* MP0002873_normal_phenotype0.54909880
128MP0003861_abnormal_nervous_system0.54880213
129MP0003303_peritoneal_inflammation0.54254532
130MP0000015_abnormal_ear_pigmentation0.54060317
131MP0010769_abnormal_survival0.53659831
132* MP0002169_no_abnormal_phenotype0.53172162
133MP0008877_abnormal_DNA_methylation0.51151851
134MP0010768_mortality/aging0.51000981
135MP0001943_abnormal_respiration0.50876039

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.85996797
2Myokymia (HP:0002411)6.30796439
3Focal seizures (HP:0007359)5.20641814
4Visual hallucinations (HP:0002367)4.98271631
5Epileptic encephalopathy (HP:0200134)3.85182797
6Ankle clonus (HP:0011448)3.52256282
7Absence seizures (HP:0002121)3.50591897
8Atonic seizures (HP:0010819)3.45911506
9Febrile seizures (HP:0002373)3.39611076
10Neuronal loss in central nervous system (HP:0002529)3.32829041
11Supranuclear gaze palsy (HP:0000605)3.30258330
12Action tremor (HP:0002345)3.25928938
13Cerebral hypomyelination (HP:0006808)3.23767115
14Generalized tonic-clonic seizures (HP:0002069)3.20045579
15Tetraplegia (HP:0002445)3.12962976
16Progressive cerebellar ataxia (HP:0002073)3.10599126
17Dialeptic seizures (HP:0011146)3.09422951
18Delusions (HP:0000746)3.03885765
19Hypotrichosis (HP:0001006)2.94685387
20Impaired vibration sensation in the lower limbs (HP:0002166)2.87752904
21Depression (HP:0000716)2.87378284
22Megalencephaly (HP:0001355)2.85883670
23Peripheral hypomyelination (HP:0007182)2.83646631
24Broad-based gait (HP:0002136)2.81410259
25Amblyopia (HP:0000646)2.77163008
26Papilledema (HP:0001085)2.73032257
27Obstructive sleep apnea (HP:0002870)2.70581200
28Torticollis (HP:0000473)2.68864779
29Slow saccadic eye movements (HP:0000514)2.67729584
30Mutism (HP:0002300)2.63203343
31Ankyloglossia (HP:0010296)2.63150807
32Ventricular fibrillation (HP:0001663)2.61937051
33Milia (HP:0001056)2.60194507
34Poor eye contact (HP:0000817)2.59398324
35Clonus (HP:0002169)2.57500993
36Urinary bladder sphincter dysfunction (HP:0002839)2.54944297
37Aplasia involving bones of the extremities (HP:0009825)2.54324897
38Aplasia involving bones of the upper limbs (HP:0009823)2.54324897
39Aplasia of the phalanges of the hand (HP:0009802)2.54324897
40Abnormal eating behavior (HP:0100738)2.53603034
41Status epilepticus (HP:0002133)2.52407904
42Cerebral inclusion bodies (HP:0100314)2.51738228
43Plantar hyperkeratosis (HP:0007556)2.50876489
44Dysdiadochokinesis (HP:0002075)2.49646782
45Fragile nails (HP:0001808)2.45172475
46Urinary urgency (HP:0000012)2.43026401
47Stereotypic behavior (HP:0000733)2.42073170
48Impaired social interactions (HP:0000735)2.38027240
49Abnormal social behavior (HP:0012433)2.38027240
50Spinal canal stenosis (HP:0003416)2.37407151
51Neurofibrillary tangles (HP:0002185)2.36527880
52Intention tremor (HP:0002080)2.35267740
53Truncal ataxia (HP:0002078)2.34676241
54Gaze-evoked nystagmus (HP:0000640)2.34151033
55Focal dystonia (HP:0004373)2.32880765
56Insidious onset (HP:0003587)2.32403923
57Termporal pattern (HP:0011008)2.32403923
58Dysmetria (HP:0001310)2.32043712
59Rigidity (HP:0002063)2.31965693
60Anxiety (HP:0000739)2.30450790
61Eczematoid dermatitis (HP:0000976)2.29361482
62Lower limb amyotrophy (HP:0007210)2.28011523
63Postural instability (HP:0002172)2.24819043
64Abnormality of binocular vision (HP:0011514)2.23180269
65Diplopia (HP:0000651)2.23180269
66Genetic anticipation (HP:0003743)2.22874900
67Abnormality of the lower motor neuron (HP:0002366)2.18931576
68Palmoplantar hyperkeratosis (HP:0000972)2.18417957
69Annular pancreas (HP:0001734)2.18067188
70Abnormality of oral frenula (HP:0000190)2.13943991
71Impaired smooth pursuit (HP:0007772)2.13733339
72Craniofacial dystonia (HP:0012179)2.13364551
73Lower limb asymmetry (HP:0100559)2.13224853
74Fetal akinesia sequence (HP:0001989)2.12477798
75Pointed chin (HP:0000307)2.12463888
76Abnormality of saccadic eye movements (HP:0000570)2.10689507
77Spastic gait (HP:0002064)2.08621715
78Spastic tetraparesis (HP:0001285)2.06618681
79Woolly hair (HP:0002224)2.05657978
80Onycholysis (HP:0001806)2.04453596
81Hypoventilation (HP:0002791)2.04208035
82Hyperventilation (HP:0002883)2.02560362
83Hemiplegia (HP:0002301)2.01095877
84Apathy (HP:0000741)1.98197012
85Excessive salivation (HP:0003781)1.97547226
86Drooling (HP:0002307)1.97547226
87Epileptiform EEG discharges (HP:0011182)1.97294532
88Bowel incontinence (HP:0002607)1.96841382
89Rapidly progressive (HP:0003678)1.96573150
90Achilles tendon contracture (HP:0001771)1.95959073
91Palmar hyperkeratosis (HP:0010765)1.95703899
92Truncus arteriosus (HP:0001660)1.93753227
93Upper limb amyotrophy (HP:0009129)1.93574444
94Distal upper limb amyotrophy (HP:0007149)1.93574444
95Memory impairment (HP:0002354)1.92955036
96Progressive inability to walk (HP:0002505)1.92850617
97Hyperthyroidism (HP:0000836)1.92695791
98Insomnia (HP:0100785)1.91761204
99Polyphagia (HP:0002591)1.90938491
100Hemiparesis (HP:0001269)1.89814927
101Limb dystonia (HP:0002451)1.89297636
102Impaired vibratory sensation (HP:0002495)1.87433122
103Sleep apnea (HP:0010535)1.86335168
104Akinesia (HP:0002304)1.86220485
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85390538
106Ocular albinism (HP:0001107)1.85036375
107Abnormality of the periventricular white matter (HP:0002518)1.83538162
108Scanning speech (HP:0002168)1.83411402
109Broad face (HP:0000283)1.82724651
110Lower limb muscle weakness (HP:0007340)1.82201124
111Bradykinesia (HP:0002067)1.81597311
112Erythema (HP:0010783)1.81455695
113Hamartoma of the eye (HP:0010568)1.80847904
114Bronchomalacia (HP:0002780)1.79397101
115Growth hormone excess (HP:0000845)1.79097968
116Diminished motivation (HP:0000745)1.78299193
117Intellectual disability, profound (HP:0002187)1.77979698
118Generalized myoclonic seizures (HP:0002123)1.76767487
119CNS hypomyelination (HP:0003429)1.76258179
120Abnormal large intestine physiology (HP:0012700)1.76230809
121Abnormality of the corticospinal tract (HP:0002492)1.76179312
122Dysmetric saccades (HP:0000641)1.75386081
123Abnormality of ocular smooth pursuit (HP:0000617)1.74376156
124Atrophic scars (HP:0001075)1.72988335
125Absent speech (HP:0001344)1.72733220
126Increased IgE level (HP:0003212)1.72510815
127Distal sensory impairment (HP:0002936)1.72192714
128Neoplasm of the heart (HP:0100544)1.71857490
129Dementia (HP:0000726)1.70604463
130Split foot (HP:0001839)1.69834836
131Deep palmar crease (HP:0006191)1.69811539
132Thickened helices (HP:0000391)1.69710242
133Exotropia (HP:0000577)1.67794613
134Choreoathetosis (HP:0001266)1.67059558
135Deeply set eye (HP:0000490)1.65911198

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.94262207
2MAP3K94.28835484
3NTRK33.62695565
4MARK12.94766374
5DAPK22.81457859
6MAP3K42.50392115
7MINK12.48697828
8PAK62.48371421
9NTRK22.39693251
10KSR22.36256659
11MAP3K122.09744849
12RIPK41.99667560
13PRKD31.98984549
14MAP3K21.95361164
15KSR11.88088496
16CAMKK11.86852593
17TYRO31.79227089
18NTRK11.78601519
19MAP2K71.75931152
20MAP2K41.71465721
21CDK191.67973791
22CDK51.56098341
23DAPK11.54925099
24SIK21.43327829
25TAOK11.42727967
26LATS21.31262306
27STK381.24099292
28MAP3K111.18016348
29CASK1.14607143
30ARAF1.11747864
31GRK51.11543572
32PLK21.09506920
33FGFR21.08658830
34STK111.07964161
35FER1.07152514
36UHMK11.05741185
37RAF11.05285630
38RET1.03761409
39MAPK131.02972960
40PRKCG0.99875445
41NEK60.98580552
42MAP3K130.94397072
43CAMK10.90535810
44SMG10.89484055
45MARK20.88968083
46PHKG20.87955074
47PHKG10.87955074
48CDK180.87809285
49PAK30.86978805
50CDK150.85578289
51BRSK10.84125698
52ICK0.83880937
53TNIK0.82667712
54BRAF0.81831632
55PRPF4B0.81233384
56CAMKK20.80908792
57PRKCH0.80757125
58DMPK0.80221019
59RIPK10.79952054
60DDR20.78206287
61CAMK2A0.77812962
62CDK140.77612578
63CDK11A0.75844885
64MAPK100.74444614
65MAP3K10.73974928
66TRIB30.73464997
67MAP4K10.71087315
68MAP3K70.69819753
69FES0.69305649
70CDK120.68777802
71LMTK20.67257382
72SIK10.66874516
73MST1R0.66255255
74SGK20.64508918
75TNK20.63659415
76PTK2B0.63580715
77HIPK20.61164576
78IRAK20.61115028
79EPHB20.60265993
80DYRK1A0.59825481
81JAK20.58855856
82WNK10.58831310
83BMPR20.58424557
84MAP2K10.57708015
85PINK10.57672687
86OXSR10.57367841
87PDGFRA0.56341369
88FGFR30.56181996
89MAPKAPK50.55988689
90EEF2K0.54701394
91ALK0.54597001
92SGK10.53892063
93TAOK20.53692813
94CSNK1G20.52644790
95MAPKAPK30.52342145
96PDK10.52282025
97JAK10.51371906
98FYN0.50972939
99MAPK40.50934181
100CAMK2B0.49088655
101PDPK10.47840394
102DAPK30.47424096
103BCR0.47253440
104MAPK70.46052731
105PRKD20.45494049
106SGK2230.45405747
107SGK4940.45405747
108SYK0.44926457
109RPS6KA20.44840696
110PNCK0.44827938
111CCNB10.44633282
112ROCK20.42556416
113MAP3K100.42095627
114FGR0.40978230
115PRKCZ0.40717869
116MAP2K60.40008767
117ZAP700.39859871
118ERN10.39181927
119MAP2K20.38944392
120MAP3K60.38541342
121MAPK80.38496220
122RPS6KA30.38141552
123PRKCE0.37878416
124GRK60.37526638
125MAPK120.37317365
126CAMK40.36998634
127ERBB30.34731161
128FGFR10.34395653
129SGK30.32191826

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.91491001
2Nicotine addiction_Homo sapiens_hsa050332.91013762
3Olfactory transduction_Homo sapiens_hsa047402.57388325
4Long-term potentiation_Homo sapiens_hsa047202.51262345
5Circadian entrainment_Homo sapiens_hsa047132.40459232
6Glutamatergic synapse_Homo sapiens_hsa047242.32147284
7Amphetamine addiction_Homo sapiens_hsa050312.23828799
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23648335
9Salivary secretion_Homo sapiens_hsa049702.10186459
10GABAergic synapse_Homo sapiens_hsa047272.08360706
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06828195
12Morphine addiction_Homo sapiens_hsa050322.02719822
13Dopaminergic synapse_Homo sapiens_hsa047281.99260359
14Gastric acid secretion_Homo sapiens_hsa049711.87268114
15Cholinergic synapse_Homo sapiens_hsa047251.80580547
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79665983
17Oxytocin signaling pathway_Homo sapiens_hsa049211.73791893
18Renin secretion_Homo sapiens_hsa049241.73190503
19Insulin secretion_Homo sapiens_hsa049111.70800352
20GnRH signaling pathway_Homo sapiens_hsa049121.66334041
21Long-term depression_Homo sapiens_hsa047301.64102976
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62643468
23Cocaine addiction_Homo sapiens_hsa050301.52395851
24Serotonergic synapse_Homo sapiens_hsa047261.51999939
25Calcium signaling pathway_Homo sapiens_hsa040201.50400841
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.47772413
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43780204
28Vitamin B6 metabolism_Homo sapiens_hsa007501.42017582
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41825183
30Gap junction_Homo sapiens_hsa045401.41152391
31Melanogenesis_Homo sapiens_hsa049161.39672156
32Taste transduction_Homo sapiens_hsa047421.38711787
33* Axon guidance_Homo sapiens_hsa043601.38385127
34Glioma_Homo sapiens_hsa052141.35498947
35ErbB signaling pathway_Homo sapiens_hsa040121.27814408
36Estrogen signaling pathway_Homo sapiens_hsa049151.26626935
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25493975
38Collecting duct acid secretion_Homo sapiens_hsa049661.19717863
39cAMP signaling pathway_Homo sapiens_hsa040241.19672032
40VEGF signaling pathway_Homo sapiens_hsa043701.16951262
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11341986
42Dorso-ventral axis formation_Homo sapiens_hsa043201.05157726
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00284602
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98868260
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.97565589
46Type II diabetes mellitus_Homo sapiens_hsa049300.95200136
47Acute myeloid leukemia_Homo sapiens_hsa052210.94062492
48Choline metabolism in cancer_Homo sapiens_hsa052310.90119551
49Endometrial cancer_Homo sapiens_hsa052130.84030540
50Pancreatic secretion_Homo sapiens_hsa049720.83856525
51Oocyte meiosis_Homo sapiens_hsa041140.81766396
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.81619537
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81341702
54Prion diseases_Homo sapiens_hsa050200.81114538
55Wnt signaling pathway_Homo sapiens_hsa043100.79133211
56MAPK signaling pathway_Homo sapiens_hsa040100.79047832
57Dilated cardiomyopathy_Homo sapiens_hsa054140.78717235
58Rap1 signaling pathway_Homo sapiens_hsa040150.78632499
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78140789
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.78034419
61Non-small cell lung cancer_Homo sapiens_hsa052230.76824275
62Vibrio cholerae infection_Homo sapiens_hsa051100.76647132
63Ras signaling pathway_Homo sapiens_hsa040140.75708996
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75519064
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73330662
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73250851
67B cell receptor signaling pathway_Homo sapiens_hsa046620.72954792
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72123079
69Chronic myeloid leukemia_Homo sapiens_hsa052200.68575915
70Phototransduction_Homo sapiens_hsa047440.67892424
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67816108
72mTOR signaling pathway_Homo sapiens_hsa041500.67351658
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66603330
74Basal cell carcinoma_Homo sapiens_hsa052170.65958119
75Endocytosis_Homo sapiens_hsa041440.65405629
76Hedgehog signaling pathway_Homo sapiens_hsa043400.64797481
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64213755
78Thyroid hormone synthesis_Homo sapiens_hsa049180.61272643
79Renal cell carcinoma_Homo sapiens_hsa052110.61156191
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60574470
81Inositol phosphate metabolism_Homo sapiens_hsa005620.59186049
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59092282
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58476428
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58467440
85Hippo signaling pathway_Homo sapiens_hsa043900.57185204
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55085138
87Colorectal cancer_Homo sapiens_hsa052100.54859959
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54793421
89Cardiac muscle contraction_Homo sapiens_hsa042600.53930415
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53684946
91Nitrogen metabolism_Homo sapiens_hsa009100.53601396
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53455355
93Tight junction_Homo sapiens_hsa045300.52445412
94T cell receptor signaling pathway_Homo sapiens_hsa046600.52146377
95Platelet activation_Homo sapiens_hsa046110.50236728
96Glucagon signaling pathway_Homo sapiens_hsa049220.49630385
97Proteoglycans in cancer_Homo sapiens_hsa052050.49057263
98Circadian rhythm_Homo sapiens_hsa047100.48260540
99Alcoholism_Homo sapiens_hsa050340.48180565
100Osteoclast differentiation_Homo sapiens_hsa043800.47757000
101Chemokine signaling pathway_Homo sapiens_hsa040620.46651026
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46560702
103HIF-1 signaling pathway_Homo sapiens_hsa040660.45814923
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45382934
105Insulin signaling pathway_Homo sapiens_hsa049100.44837381
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42972414
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42791107
108Prolactin signaling pathway_Homo sapiens_hsa049170.42393663
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41919939
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41736447
111Tuberculosis_Homo sapiens_hsa051520.40830937
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40162848
113Bile secretion_Homo sapiens_hsa049760.40068344
114Ovarian steroidogenesis_Homo sapiens_hsa049130.40016405
115Notch signaling pathway_Homo sapiens_hsa043300.38839132
116Pancreatic cancer_Homo sapiens_hsa052120.38365565
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36676728
118Thyroid cancer_Homo sapiens_hsa052160.36112380
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35704495
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33395097
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.32227725
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.32200390

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