EPHX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* epoxygenase P450 pathway (GO:0019373)7.47597987
2exogenous drug catabolic process (GO:0042738)7.02534872
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.96466365
4L-phenylalanine catabolic process (GO:0006559)6.96466365
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.72493915
6L-phenylalanine metabolic process (GO:0006558)6.72493915
7aromatic amino acid family catabolic process (GO:0009074)6.25833389
8glyoxylate metabolic process (GO:0046487)5.99768890
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.95341093
10omega-hydroxylase P450 pathway (GO:0097267)5.83251356
11alpha-linolenic acid metabolic process (GO:0036109)5.66926254
12tryptophan catabolic process (GO:0006569)5.64290591
13indole-containing compound catabolic process (GO:0042436)5.64290591
14indolalkylamine catabolic process (GO:0046218)5.64290591
15* drug metabolic process (GO:0017144)5.58975440
16kynurenine metabolic process (GO:0070189)5.54892800
17bile acid biosynthetic process (GO:0006699)5.52171046
18tryptophan metabolic process (GO:0006568)5.31182604
19cysteine metabolic process (GO:0006534)5.27685076
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.24390855
21sulfur amino acid catabolic process (GO:0000098)5.20093857
22urea cycle (GO:0000050)5.19097992
23urea metabolic process (GO:0019627)5.19097992
24lysine metabolic process (GO:0006553)5.14347714
25lysine catabolic process (GO:0006554)5.14347714
26regulation of triglyceride catabolic process (GO:0010896)4.98615781
27high-density lipoprotein particle remodeling (GO:0034375)4.96257921
28serine family amino acid catabolic process (GO:0009071)4.91208969
29complement activation, alternative pathway (GO:0006957)4.89548467
30homocysteine metabolic process (GO:0050667)4.81087363
31amino-acid betaine metabolic process (GO:0006577)4.79565017
32nitrogen cycle metabolic process (GO:0071941)4.79265928
33negative regulation of fibrinolysis (GO:0051918)4.77407448
34regulation of protein activation cascade (GO:2000257)4.71334317
35bile acid metabolic process (GO:0008206)4.70026824
36peptidyl-glutamic acid carboxylation (GO:0017187)4.64480465
37protein carboxylation (GO:0018214)4.64480465
38ethanol metabolic process (GO:0006067)4.62743582
39regulation of fibrinolysis (GO:0051917)4.56767494
40aromatic amino acid family metabolic process (GO:0009072)4.55154894
41fat-soluble vitamin biosynthetic process (GO:0042362)4.54866193
42alpha-amino acid catabolic process (GO:1901606)4.49479765
43cellular ketone body metabolic process (GO:0046950)4.48803063
44triglyceride homeostasis (GO:0070328)4.47733228
45acylglycerol homeostasis (GO:0055090)4.47733228
46reverse cholesterol transport (GO:0043691)4.45319861
47regulation of complement activation (GO:0030449)4.44407592
48oxidative demethylation (GO:0070989)4.43903400
49regulation of cholesterol esterification (GO:0010872)4.38774466
50plasma lipoprotein particle remodeling (GO:0034369)4.38168611
51protein-lipid complex remodeling (GO:0034368)4.38168611
52macromolecular complex remodeling (GO:0034367)4.38168611
53tyrosine metabolic process (GO:0006570)4.36207083
54alkaloid metabolic process (GO:0009820)4.26057089
55fatty acid beta-oxidation (GO:0006635)4.25492743
56plasma lipoprotein particle clearance (GO:0034381)4.24321269
57hormone catabolic process (GO:0042447)4.23098955
58cellular amino acid catabolic process (GO:0009063)4.22293075
59coenzyme catabolic process (GO:0009109)4.17650436
60acetyl-CoA metabolic process (GO:0006084)4.16736206
61phospholipid efflux (GO:0033700)4.14379691
62intestinal absorption (GO:0050892)4.13495204
63flavonoid metabolic process (GO:0009812)4.11579745
64ethanol oxidation (GO:0006069)4.10063767
65short-chain fatty acid metabolic process (GO:0046459)4.08728146
66fatty acid oxidation (GO:0019395)4.08345709
67negative regulation of sterol transport (GO:0032372)4.07570742
68negative regulation of cholesterol transport (GO:0032375)4.07570742
692-oxoglutarate metabolic process (GO:0006103)4.06836612
70glutamate metabolic process (GO:0006536)4.04489039
71glycine metabolic process (GO:0006544)4.03717779
72serine family amino acid metabolic process (GO:0009069)4.01686762
73lipid oxidation (GO:0034440)4.01626330
74blood coagulation, intrinsic pathway (GO:0007597)4.00647204
75cellular modified amino acid catabolic process (GO:0042219)3.99773288
76fatty acid catabolic process (GO:0009062)3.98474310
77indolalkylamine metabolic process (GO:0006586)3.96251758
78benzene-containing compound metabolic process (GO:0042537)3.95263360
79cellular glucuronidation (GO:0052695)3.94395846
80dicarboxylic acid biosynthetic process (GO:0043650)3.92876592
81* phenylpropanoid metabolic process (GO:0009698)3.92739454
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.92648509
83drug catabolic process (GO:0042737)3.91748997
84monocarboxylic acid catabolic process (GO:0072329)3.90694635
85organic acid catabolic process (GO:0016054)3.89951504
86carboxylic acid catabolic process (GO:0046395)3.89951504
87positive regulation of lipid catabolic process (GO:0050996)3.89844241
88S-adenosylmethionine metabolic process (GO:0046500)3.89630822
89cellular biogenic amine catabolic process (GO:0042402)3.87668539
90amine catabolic process (GO:0009310)3.87668539
91ketone body metabolic process (GO:1902224)3.87250032
92bile acid and bile salt transport (GO:0015721)3.86319683
93aspartate family amino acid catabolic process (GO:0009068)3.85486273
94cholesterol efflux (GO:0033344)3.82238072
95carnitine metabolic process (GO:0009437)3.79149024
96phospholipid homeostasis (GO:0055091)3.77609273
97angiotensin maturation (GO:0002003)3.75906987
98regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.75368088
99plasma lipoprotein particle assembly (GO:0034377)3.74913986
100fructose metabolic process (GO:0006000)3.73685941
101valine metabolic process (GO:0006573)3.72009829
102serine family amino acid biosynthetic process (GO:0009070)3.70861740
103arginine metabolic process (GO:0006525)3.69638560
104imidazole-containing compound metabolic process (GO:0052803)3.69465527
105drug transmembrane transport (GO:0006855)3.64074672
106negative regulation of protein activation cascade (GO:2000258)3.62540939
107positive regulation of lipoprotein lipase activity (GO:0051006)3.62236641
108positive regulation of triglyceride lipase activity (GO:0061365)3.62236641
109negative regulation of lipase activity (GO:0060192)3.60886904
110regulation of cholesterol homeostasis (GO:2000188)3.60781725
111aldehyde catabolic process (GO:0046185)3.58674804
112very-low-density lipoprotein particle assembly (GO:0034379)3.57328185
113intestinal cholesterol absorption (GO:0030299)3.56257489
114regulation of bile acid biosynthetic process (GO:0070857)3.53994575
115* cholesterol homeostasis (GO:0042632)3.53468170
116branched-chain amino acid catabolic process (GO:0009083)3.52788181
117uronic acid metabolic process (GO:0006063)3.52583674
118glucuronate metabolic process (GO:0019585)3.52583674
119NADH metabolic process (GO:0006734)3.52567628
120urate metabolic process (GO:0046415)3.51150371
121xenobiotic catabolic process (GO:0042178)3.49260591
122protein activation cascade (GO:0072376)3.48015359
123primary alcohol metabolic process (GO:0034308)3.46556170
124heme transport (GO:0015886)3.42650090
125complement activation, classical pathway (GO:0006958)3.40380024
126plasma lipoprotein particle organization (GO:0071827)3.40168515
127vitamin biosynthetic process (GO:0009110)3.37557309
128* xenobiotic metabolic process (GO:0006805)3.35671476
129protein-lipid complex assembly (GO:0065005)3.30793448
130fibrinolysis (GO:0042730)3.30210859
131drug transport (GO:0015893)3.27701285
132lipoprotein transport (GO:0042953)3.24023926
133complement activation (GO:0006956)3.23723335
134diacylglycerol metabolic process (GO:0046339)3.20321837
135lipoprotein metabolic process (GO:0042157)3.19050949
136protein-lipid complex subunit organization (GO:0071825)3.14979313
137arginine catabolic process (GO:0006527)3.10400477
138negative regulation of complement activation (GO:0045916)3.10377310
139L-ascorbic acid metabolic process (GO:0019852)3.09456505
140negative regulation of blood coagulation (GO:0030195)3.09134765
141negative regulation of hemostasis (GO:1900047)3.09134765
142* sterol homeostasis (GO:0055092)3.04960113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.97624091
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.92002943
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.62125476
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.28646589
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.24285726
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06140263
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.55514709
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.95134530
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.51868840
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.98408208
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28630061
12CLOCK_20551151_ChIP-Seq_293T_Human2.10759040
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.09361396
14* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08505834
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07417930
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2931349
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.61965743
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60385171
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58147102
20GATA1_22025678_ChIP-Seq_K562_Human1.57207744
21FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47436476
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41654783
23* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35702212
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35379322
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.33802737
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29446578
27IGF1R_20145208_ChIP-Seq_DFB_Human1.29235567
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28357677
29IRF1_19129219_ChIP-ChIP_H3396_Human1.25711402
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24233502
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22002930
32* HTT_18923047_ChIP-ChIP_STHdh_Human1.20681315
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18807607
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17648859
35HNFA_21074721_ChIP-Seq_CACO-2_Human1.16607918
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15296793
37FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12376804
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.11560610
39PHF8_20622853_ChIP-Seq_HELA_Human1.11049317
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09600328
41CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08688556
42* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07331106
43TCF4_22108803_ChIP-Seq_LS180_Human1.07005531
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06350768
45* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04664938
46NCOR_22424771_ChIP-Seq_293T_Human1.04281923
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.02418462
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02418462
49ER_23166858_ChIP-Seq_MCF-7_Human1.00765530
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00457302
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00273643
52NANOG_20526341_ChIP-Seq_ESCs_Human1.00062782
53ZNF263_19887448_ChIP-Seq_K562_Human0.99963471
54MYC_19829295_ChIP-Seq_ESCs_Human0.99888258
55NFYA_21822215_ChIP-Seq_K562_Human0.99870209
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96653510
57GATA3_21878914_ChIP-Seq_MCF-7_Human0.95749796
58ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94501321
59PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93658236
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92259228
61NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91949221
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91499576
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91458610
64GATA6_21074721_ChIP-Seq_CACO-2_Human0.91421671
65VDR_22108803_ChIP-Seq_LS180_Human0.91035717
66PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.90561353
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90392904
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90375832
69GATA4_25053715_ChIP-Seq_YYC3_Human0.90080631
70* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89916418
71ETV1_20927104_ChIP-Seq_GIST48_Human0.89450926
72NFE2_27457419_Chip-Seq_LIVER_Mouse0.88516220
73EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87969830
74NFYB_21822215_ChIP-Seq_K562_Human0.87239369
75CBX2_22325352_ChIP-Seq_293T-Rex_Human0.86393511
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86250980
77NANOG_19829295_ChIP-Seq_ESCs_Human0.86073884
78SOX2_19829295_ChIP-Seq_ESCs_Human0.86073884
79ESR2_21235772_ChIP-Seq_MCF-7_Human0.85948067
80AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84677176
81RBPJ_21746931_ChIP-Seq_IB4_Human0.84608314
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84232710
83DROSHA_22980978_ChIP-Seq_HELA_Human0.83740272
84TBL1_22424771_ChIP-Seq_293T_Human0.82380364
85STAT3_23295773_ChIP-Seq_U87_Human0.82101556
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81679624
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.81328375
88FOXH1_21741376_ChIP-Seq_ESCs_Human0.81100464
89OCT4_20526341_ChIP-Seq_ESCs_Human0.80612494
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80603247
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80269289
92SOX2_22085726_ChIP-Seq_NPCs_Mouse0.78983950
93ZNF274_21170338_ChIP-Seq_K562_Hela0.78143038
94STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77551976
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77179834
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76876718
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76283472
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.75538030
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74384591
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72325489
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71763734
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71763734
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71223809
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70107990
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.69800274
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68539312
107PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68009366
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66502501
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.65818957
110RARA_24833708_ChIP-Seq_LIVER_Mouse0.64532807
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.64524781
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63925617
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63060031
114CEBPB_22108803_ChIP-Seq_LS180_Human0.62360942
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.61556444
116EGR1_19032775_ChIP-ChIP_M12_Human0.58366699
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.58281928
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.58281928
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57611764
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57168623
121IRF8_22096565_ChIP-ChIP_GC-B_Human0.56620748
122LXR_22292898_ChIP-Seq_THP-1_Human0.54200107
123AR_20517297_ChIP-Seq_VCAP_Human0.53605577
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53472362
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.53325395
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.52301908
127BCAT_22108803_ChIP-Seq_LS180_Human0.51698145
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.51055671
129CBP_21632823_ChIP-Seq_H3396_Human0.51011191
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.50141389
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49846975
132FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49116094
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.48939490
134GATA6_25053715_ChIP-Seq_YYC3_Human0.47310480
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46899155
136GATA1_19941826_ChIP-Seq_K562_Human0.46386375
137MYC_19915707_ChIP-ChIP_AK7_Human0.46027250
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.45931699
139* GATA2_19941826_ChIP-Seq_K562_Human0.45162362
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44826808
141TAF2_19829295_ChIP-Seq_ESCs_Human0.43978720
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.43801258
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.43778110
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.43461222
145PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43278024
146SOX2_20726797_ChIP-Seq_SW620_Human0.42223064
147STAT1_17558387_ChIP-Seq_HELA_Human0.41404426
148P53_21459846_ChIP-Seq_SAOS-2_Human0.41361281
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39183297
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.38168392
151* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37745370
152* CDX2_22108803_ChIP-Seq_LS180_Human0.37676584
153RACK7_27058665_Chip-Seq_MCF-7_Human0.37616320
154ERG_20517297_ChIP-Seq_VCAP_Human0.37182351
155CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36958817
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36936750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.85753945
2MP0005360_urolithiasis7.40598980
3MP0005085_abnormal_gallbladder_physiolo6.02358849
4MP0005365_abnormal_bile_salt5.90365825
5MP0008875_abnormal_xenobiotic_pharmacok4.72056932
6MP0003806_abnormal_nucleotide_metabolis3.95863403
7MP0003252_abnormal_bile_duct3.76251922
8MP0010329_abnormal_lipoprotein_level3.61799337
9MP0003195_calcinosis3.02920039
10MP0009840_abnormal_foam_cell3.00771328
11MP0005332_abnormal_amino_acid2.99340990
12MP0001666_abnormal_nutrient_absorption2.53906008
13MP0005083_abnormal_biliary_tract2.53759323
14MP0003191_abnormal_cellular_cholesterol2.28434185
15MP0002118_abnormal_lipid_homeostasis2.24328455
16MP0004019_abnormal_vitamin_homeostasis2.23189428
17MP0000609_abnormal_liver_physiology2.13469005
18MP0005670_abnormal_white_adipose1.92947702
19MP0005319_abnormal_enzyme/_coenzyme1.88329193
20MP0002138_abnormal_hepatobiliary_system1.86812098
21MP0001764_abnormal_homeostasis1.67100436
22MP0005584_abnormal_enzyme/coenzyme_acti1.65298775
23MP0003183_abnormal_peptide_metabolism1.60879559
24MP0003868_abnormal_feces_composition1.60868885
25MP0004130_abnormal_muscle_cell1.51390747
26MP0009643_abnormal_urine_homeostasis1.47068389
27MP0003186_abnormal_redox_activity1.45054311
28MP0005451_abnormal_body_composition1.39900504
29MP0000566_synostosis1.35125518
30MP0003879_abnormal_hair_cell1.34591255
31MP0009697_abnormal_copulation1.33783540
32MP0002837_dystrophic_cardiac_calcinosis1.31925432
33MP0003705_abnormal_hypodermis_morpholog1.27945040
34MP0004264_abnormal_extraembryonic_tissu1.26928199
35MP0005666_abnormal_adipose_tissue1.25803593
36MP0003011_delayed_dark_adaptation1.24845733
37MP0006036_abnormal_mitochondrial_physio1.24102504
38MP0005647_abnormal_sex_gland1.19349467
39MP0002909_abnormal_adrenal_gland1.15218943
40MP0002971_abnormal_brown_adipose1.13086674
41MP0000598_abnormal_liver_morphology1.12041441
42MP0010234_abnormal_vibrissa_follicle1.09170602
43MP0003656_abnormal_erythrocyte_physiolo1.07465672
44MP0002254_reproductive_system_inflammat1.03450844
45MP0002876_abnormal_thyroid_physiology1.03240946
46MP0005379_endocrine/exocrine_gland_phen0.99577803
47MP0005636_abnormal_mineral_homeostasis0.99455935
48MP0002638_abnormal_pupillary_reflex0.99361702
49MP0005535_abnormal_body_temperature0.97763759
50MP0005334_abnormal_fat_pad0.94264413
51MP0009764_decreased_sensitivity_to0.93341303
52MP0002078_abnormal_glucose_homeostasis0.93291762
53MP0009763_increased_sensitivity_to0.92144902
54MP0000604_amyloidosis0.91115166
55MP0009780_abnormal_chondrocyte_physiolo0.89572003
56MP0002132_abnormal_respiratory_system0.88535872
57MP0003122_maternal_imprinting0.88449429
58MP0009642_abnormal_blood_homeostasis0.87095588
59MP0001501_abnormal_sleep_pattern0.86347828
60MP0001661_extended_life_span0.86115195
61MP0010368_abnormal_lymphatic_system0.85792511
62MP0010155_abnormal_intestine_physiology0.85273764
63MP0003878_abnormal_ear_physiology0.84707183
64MP0005377_hearing/vestibular/ear_phenot0.84707183
65MP0001664_abnormal_digestion0.84646699
66MP0009379_abnormal_foot_pigmentation0.84475606
67MP0001756_abnormal_urination0.81221402
68MP0006035_abnormal_mitochondrial_morpho0.81141092
69MP0001485_abnormal_pinna_reflex0.80235917
70MP0008469_abnormal_protein_level0.78165260
71MP0005084_abnormal_gallbladder_morpholo0.77932312
72MP0003690_abnormal_glial_cell0.77055626
73* MP0005376_homeostasis/metabolism_phenot0.76804175
74MP0004043_abnormal_pH_regulation0.73436746
75MP0005551_abnormal_eye_electrophysiolog0.72873617
76MP0003866_abnormal_defecation0.71997212
77MP0005448_abnormal_energy_balance0.69098845
78MP0002163_abnormal_gland_morphology0.68670298
79MP0004185_abnormal_adipocyte_glucose0.67227281
80* MP0005266_abnormal_metabolism0.65829111
81MP0009115_abnormal_fat_cell0.65328311
82MP0001944_abnormal_pancreas_morphology0.65143136
83MP0005375_adipose_tissue_phenotype0.64833832
84MP0001986_abnormal_taste_sensitivity0.64803847
85MP0009765_abnormal_xenobiotic_induced0.64496332
86MP0001984_abnormal_olfaction0.63794828
87MP0002938_white_spotting0.61648194
88MP0003646_muscle_fatigue0.61518069
89MP0000538_abnormal_urinary_bladder0.61203894
90MP0002136_abnormal_kidney_physiology0.60696046
91MP0005645_abnormal_hypothalamus_physiol0.60334564
92MP0005330_cardiomyopathy0.59094691
93MP0005408_hypopigmentation0.58970161
94MP0003329_amyloid_beta_deposits0.55915965
95MP0002970_abnormal_white_adipose0.54189899
96MP0005220_abnormal_exocrine_pancreas0.52804146
97MP0009384_cardiac_valve_regurgitation0.52649239
98MP0003953_abnormal_hormone_level0.51970440
99MP0000639_abnormal_adrenal_gland0.51030665
100MP0008775_abnormal_heart_ventricle0.49054704
101MP0002069_abnormal_eating/drinking_beha0.48449995
102MP0009053_abnormal_anal_canal0.48277001
103* MP0000230_abnormal_systemic_arterial0.48053295
104MP0005395_other_phenotype0.47753117
105MP0001502_abnormal_circadian_rhythm0.47080619
106MP0002796_impaired_skin_barrier0.46124848
107MP0002693_abnormal_pancreas_physiology0.45031294
108MP0000678_abnormal_parathyroid_gland0.44715420
109MP0002822_catalepsy0.44218579
110MP0000477_abnormal_intestine_morphology0.43228844
111MP0002168_other_aberrant_phenotype0.42897023
112MP0003638_abnormal_response/metabolism_0.42312017
113MP0002269_muscular_atrophy0.41806949
114MP0004270_analgesia0.41429237
115MP0004215_abnormal_myocardial_fiber0.40568634
116MP0008874_decreased_physiological_sensi0.40276602
117MP0006138_congestive_heart_failure0.38836254
118MP0004147_increased_porphyrin_level0.38293556
119MP0002135_abnormal_kidney_morphology0.37873559
120MP0001663_abnormal_digestive_system0.37599758
121MP0003959_abnormal_lean_body0.37346407
122MP0000013_abnormal_adipose_tissue0.37017089
123MP0001765_abnormal_ion_homeostasis0.36983388
124MP0005646_abnormal_pituitary_gland0.36859237
125MP0000462_abnormal_digestive_system0.36457987
126MP0003724_increased_susceptibility_to0.36387165
127MP0001881_abnormal_mammary_gland0.36152251
128MP0001853_heart_inflammation0.35957684
129MP0008873_increased_physiological_sensi0.35770508
130MP0008872_abnormal_physiological_respon0.35496888
131MP0005058_abnormal_lysosome_morphology0.35083980
132MP0001544_abnormal_cardiovascular_syste0.34491978
133MP0005385_cardiovascular_system_phenoty0.34491978
134MP0009672_abnormal_birth_weight0.34134551
135MP0002928_abnormal_bile_duct0.33628473
136MP0003075_altered_response_to0.32596614
137MP0002332_abnormal_exercise_endurance0.32482615
138MP0000249_abnormal_blood_vessel0.31728985
139MP0003718_maternal_effect0.31279031
140MP0003221_abnormal_cardiomyocyte_apopto0.30229821

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.57025931
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.55215844
3Deep venous thrombosis (HP:0002625)6.24326525
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.89071983
5Hypobetalipoproteinemia (HP:0003563)5.68904417
6* Xanthomatosis (HP:0000991)5.62462559
7Prolonged partial thromboplastin time (HP:0003645)5.39355013
8Hyperlipoproteinemia (HP:0010980)5.09400233
9Hyperammonemia (HP:0001987)4.92815118
10Hyperglycinuria (HP:0003108)4.90751452
11Complement deficiency (HP:0004431)4.89741635
12Ketosis (HP:0001946)4.65690733
13Hyperglycinemia (HP:0002154)4.61949496
14Abnormality of serine family amino acid metabolism (HP:0010894)4.60074285
15Abnormality of glycine metabolism (HP:0010895)4.60074285
16Hypolipoproteinemia (HP:0010981)4.55647324
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46361311
18Hypoglycemic coma (HP:0001325)4.40308882
19Hypoalphalipoproteinemia (HP:0003233)4.21445865
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.19915132
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.13083375
22Abnormality of fatty-acid metabolism (HP:0004359)4.11490765
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.99516114
24Joint hemorrhage (HP:0005261)3.92800055
25Abnormality of methionine metabolism (HP:0010901)3.85380339
26Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79427176
27Abnormality of the common coagulation pathway (HP:0010990)3.71034538
28Ketoacidosis (HP:0001993)3.70187122
29Fat malabsorption (HP:0002630)3.67245253
30* Epidermoid cyst (HP:0200040)3.60288711
31Abnormality of complement system (HP:0005339)3.49505088
32Hypercholesterolemia (HP:0003124)3.35559009
33Abnormality of pyrimidine metabolism (HP:0004353)3.33020501
34Dicarboxylic aciduria (HP:0003215)3.29785327
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.29785327
36Abnormality of serum amino acid levels (HP:0003112)3.25618476
37Abnormality of the intrinsic pathway (HP:0010989)3.20401512
38Abnormality of vitamin B metabolism (HP:0004340)3.17859823
39Conjugated hyperbilirubinemia (HP:0002908)3.16169228
40Metabolic acidosis (HP:0001942)3.10271161
41Abnormality of nucleobase metabolism (HP:0010932)3.10250721
42Delayed CNS myelination (HP:0002188)3.08039422
43Hyperbilirubinemia (HP:0002904)3.06101275
44Abnormality of purine metabolism (HP:0004352)2.98865831
45Lethargy (HP:0001254)2.95890876
46Gout (HP:0001997)2.88741460
47Cerebral edema (HP:0002181)2.86567568
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.84025043
49Hyperphosphaturia (HP:0003109)2.80944341
50Metabolic alkalosis (HP:0200114)2.78981912
51Generalized aminoaciduria (HP:0002909)2.78979607
52Hyperactive renin-angiotensin system (HP:0000841)2.74528009
53Hepatocellular carcinoma (HP:0001402)2.74418990
54Myocardial infarction (HP:0001658)2.72512661
55Nephritis (HP:0000123)2.64677496
56Steatorrhea (HP:0002570)2.63738473
57Hydroxyprolinuria (HP:0003080)2.52570185
58Abnormality of proline metabolism (HP:0010907)2.52570185
59Decreased circulating renin level (HP:0003351)2.51084326
60Confusion (HP:0001289)2.49829125
61Systemic lupus erythematosus (HP:0002725)2.47103332
62Hypoglycemic seizures (HP:0002173)2.45370198
63Proximal tubulopathy (HP:0000114)2.45149550
64Vascular calcification (HP:0004934)2.42875218
65Vomiting (HP:0002013)2.42864461
66Abnormal gallbladder morphology (HP:0012437)2.38199862
67Hypochromic microcytic anemia (HP:0004840)2.37448724
68Spastic diplegia (HP:0001264)2.35945071
69Cholelithiasis (HP:0001081)2.35841809
70Spontaneous abortion (HP:0005268)2.35157255
71Sensorimotor neuropathy (HP:0007141)2.34363573
72Potter facies (HP:0002009)2.34349475
73Facial shape deformation (HP:0011334)2.34349475
74Abnormal urine phosphate concentration (HP:0012599)2.34171507
75Acanthocytosis (HP:0001927)2.33356647
76Abnormality of renin-angiotensin system (HP:0000847)2.31124562
77Irritability (HP:0000737)2.31055820
78Pancreatitis (HP:0001733)2.28864133
79Nausea (HP:0002018)2.28458115
80Abnormal cartilage morphology (HP:0002763)2.28109404
81* Skin nodule (HP:0200036)2.27647678
82Myoglobinuria (HP:0002913)2.27448251
83Malnutrition (HP:0004395)2.26859696
84Neonatal onset (HP:0003623)2.26222753
85Cerebral palsy (HP:0100021)2.25314378
86Osteomalacia (HP:0002749)2.19572371
87Increased purine levels (HP:0004368)2.18419374
88Hyperuricemia (HP:0002149)2.18419374
89Abnormal gallbladder physiology (HP:0012438)2.18157456
90Cholecystitis (HP:0001082)2.18157456
91Cardiovascular calcification (HP:0011915)2.17693241
92Widely patent fontanelles and sutures (HP:0004492)2.17165298
93Late onset (HP:0003584)2.17101048
94Renal cortical cysts (HP:0000803)2.16928893
95Enlarged kidneys (HP:0000105)2.16210570
96Gingival bleeding (HP:0000225)2.15781911
97Ileus (HP:0002595)2.15557801
98Pigmentary retinal degeneration (HP:0001146)2.15366347
99Hyperinsulinemic hypoglycemia (HP:0000825)2.15283894
100Brushfield spots (HP:0001088)2.13217917
101Poikilocytosis (HP:0004447)2.12167654
102Glycosuria (HP:0003076)2.10956116
103Abnormality of urine glucose concentration (HP:0011016)2.10956116
104Mitral stenosis (HP:0001718)2.03235332
105Hypertriglyceridemia (HP:0002155)2.02608160
106Hyperaldosteronism (HP:0000859)2.00476013
107Nephrolithiasis (HP:0000787)1.99373560
108Megaloblastic anemia (HP:0001889)1.99213811
109Hypokalemia (HP:0002900)1.98678979
110Esophageal varix (HP:0002040)1.98074614
111Amyloidosis (HP:0011034)1.96856101
112Hyperglycemia (HP:0003074)1.94164807
113Abnormality of the gallbladder (HP:0005264)1.91835921
114Abnormality of chloride homeostasis (HP:0011422)1.91764427
115Rickets (HP:0002748)1.91543377
116Glomerulonephritis (HP:0000099)1.91040819
117Hemorrhage of the eye (HP:0011885)1.90812653
118Alkalosis (HP:0001948)1.90691807
119Rhabdomyolysis (HP:0003201)1.85668370
120Elevated hepatic transaminases (HP:0002910)1.84925038
121Chronic diarrhea (HP:0002028)1.83783641
122Hypothermia (HP:0002045)1.83698308
123Recurrent gram-negative bacterial infections (HP:0005420)1.83340210
124Opisthotonus (HP:0002179)1.82523140
125Hepatic necrosis (HP:0002605)1.80755551
126Abnormality of vitamin metabolism (HP:0100508)1.79503187
127Abnormality of magnesium homeostasis (HP:0004921)1.78989241
128Hypomagnesemia (HP:0002917)1.77688964

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.43574850
2ACVR1B4.74450864
3SIK14.02568554
4ERN13.63405438
5FGFR43.62234236
6INSRR2.81559835
7TRIB32.77178443
8MAP3K22.51305244
9PKN22.34774639
10ERBB42.32972912
11MST1R2.23760067
12MAP4K22.20646502
13PDK32.06563400
14PDK42.06563400
15NLK2.06535479
16LATS11.85674583
17MAP2K41.84036916
18TAOK31.83093548
19GRK11.79258907
20MAPK111.75230832
21PINK11.70117063
22AKT31.66949343
23FLT31.65307697
24OXSR11.62150793
25FRK1.57745205
26MAPKAPK31.56920148
27CAMK1D1.55337669
28PIK3CG1.55033055
29PRKAA21.52058909
30STK38L1.50572643
31CASK1.50538785
32MST41.49509989
33TNIK1.44537255
34MAP3K41.43590704
35PRKG21.38997297
36NEK91.38883901
37NTRK31.36106621
38STK391.35255065
39PDK21.35028857
40PTK61.27836438
41TNK21.27828648
42MAP3K71.24682502
43ABL21.23551744
44FGFR21.17882979
45TYK21.12490637
46LMTK21.12037317
47TIE11.11440705
48JAK21.08098539
49STK241.03583801
50RIPK11.03133834
51ADRBK21.02053649
52KDR1.01380913
53PRKAA11.00088685
54WNK40.95831169
55NEK10.95208592
56MYLK0.94817876
57DAPK20.93704300
58MAPK120.93449917
59CAMKK20.93164686
60MET0.91840539
61MAP2K20.89746564
62MAP2K30.87717465
63EPHA20.86954729
64JAK10.84676118
65GRK60.84104176
66BMPR1B0.82576852
67MAP3K30.82518867
68IRAK30.82392734
69PRKACG0.81665193
70CAMK1G0.79616870
71PIK3CA0.77902875
72CDK60.76082405
73SGK30.75685642
74PDPK10.73785514
75MAPK40.73768513
76TTN0.73670144
77PRKCZ0.72978669
78ERBB20.69665315
79TGFBR20.68906599
80MAP3K100.68814577
81EEF2K0.68262687
82GSK3A0.67226328
83TBK10.65799267
84PRKCE0.65506394
85FGFR30.63447805
86NUAK10.62730190
87CAMK2G0.61804672
88PHKG10.60914617
89PHKG20.60914617
90DMPK0.60846432
91OBSCN0.60517667
92EPHB10.59086904
93NME10.58978499
94KSR20.58355142
95STK30.57585093
96MAPK130.57197937
97CDK190.56546342
98IRAK10.55677829
99MAP3K110.54355161
100SGK20.54001242
101PRKCG0.53998004
102PRKCA0.53978991
103MAP2K10.53426081
104DYRK1B0.53144094
105MAPK70.52719467
106PRKG10.51063409
107PDK10.49842385
108SGK4940.49635794
109SGK2230.49635794
110WNK30.49107148
111PAK30.47677235
112MAP3K50.46470843
113MAP3K10.46170705
114MAP2K60.44440569
115CSK0.44210557
116IGF1R0.44197114
117CDK40.44176150
118PDGFRA0.43931324
119TEC0.41729675
120MTOR0.40796560
121CDC42BPA0.40701587
122SGK10.39973650
123TXK0.39293746
124EPHA30.38968730
125ITK0.38768805
126BCR0.38251059
127CAMK40.37898988
128MAPK150.37797943
129PRKACB0.37383952
130LATS20.37286570
131STK110.37256320
132CAMK2D0.37006693
133PRKCQ0.36911530
134RET0.36442596
135PTK20.36392718
136CSNK1A10.36182568
137MAP3K140.35675414
138ICK0.35343838
139MAP3K60.35244314
140STK380.34424062
141PRKD10.34153298
142PKN10.28144753
143PRKCH0.27645710
144FER0.27253981
145EPHA40.25916346
146PRKACA0.24249198

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03779022
2Nitrogen metabolism_Homo sapiens_hsa009103.31851688
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19750230
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.03384494
5Fatty acid degradation_Homo sapiens_hsa000712.92947466
6Arginine biosynthesis_Homo sapiens_hsa002202.84200712
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78813650
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78236310
9Tryptophan metabolism_Homo sapiens_hsa003802.65546406
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60504608
11Propanoate metabolism_Homo sapiens_hsa006402.52725540
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36775757
13Butanoate metabolism_Homo sapiens_hsa006502.34652788
14Complement and coagulation cascades_Homo sapiens_hsa046102.28415392
15Fatty acid metabolism_Homo sapiens_hsa012122.24576813
16PPAR signaling pathway_Homo sapiens_hsa033202.21973494
17* Peroxisome_Homo sapiens_hsa041462.17174750
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.15343796
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.10017934
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88491848
21beta-Alanine metabolism_Homo sapiens_hsa004101.84488277
22Pyruvate metabolism_Homo sapiens_hsa006201.71725236
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.71604858
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71169009
25Histidine metabolism_Homo sapiens_hsa003401.68714645
26Chemical carcinogenesis_Homo sapiens_hsa052041.67780551
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67193670
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67115586
29Caffeine metabolism_Homo sapiens_hsa002321.64692807
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60316264
31Phenylalanine metabolism_Homo sapiens_hsa003601.51218457
32Fatty acid elongation_Homo sapiens_hsa000621.51133685
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.49012178
34Carbon metabolism_Homo sapiens_hsa012001.48453721
35Retinol metabolism_Homo sapiens_hsa008301.47098061
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46994377
37Bile secretion_Homo sapiens_hsa049761.41954632
38Selenocompound metabolism_Homo sapiens_hsa004501.39429835
39Staphylococcus aureus infection_Homo sapiens_hsa051501.36597841
40Sulfur metabolism_Homo sapiens_hsa009201.36068376
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34881171
42Starch and sucrose metabolism_Homo sapiens_hsa005001.34034413
43Tyrosine metabolism_Homo sapiens_hsa003501.33196174
44Fat digestion and absorption_Homo sapiens_hsa049751.30973504
45Biosynthesis of amino acids_Homo sapiens_hsa012301.28407210
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.24107063
47Folate biosynthesis_Homo sapiens_hsa007901.14131015
48ABC transporters_Homo sapiens_hsa020101.07519612
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07516939
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03426804
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.99254598
52Arginine and proline metabolism_Homo sapiens_hsa003300.98241245
53Fatty acid biosynthesis_Homo sapiens_hsa000610.97374931
54Steroid biosynthesis_Homo sapiens_hsa001000.95768774
55Vitamin digestion and absorption_Homo sapiens_hsa049770.93074531
56Glycerolipid metabolism_Homo sapiens_hsa005610.89401747
57Lysine degradation_Homo sapiens_hsa003100.89006465
58Vitamin B6 metabolism_Homo sapiens_hsa007500.86743512
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86439569
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86430269
61Sulfur relay system_Homo sapiens_hsa041220.83197909
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82927269
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.81679258
64Glutathione metabolism_Homo sapiens_hsa004800.75276130
65Pentose phosphate pathway_Homo sapiens_hsa000300.62793644
66One carbon pool by folate_Homo sapiens_hsa006700.51832587
67* Metabolic pathways_Homo sapiens_hsa011000.49611766
68Ether lipid metabolism_Homo sapiens_hsa005650.48030202
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44877415
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41967934
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.41454413
72Fructose and mannose metabolism_Homo sapiens_hsa000510.40861587
73Galactose metabolism_Homo sapiens_hsa000520.38402435
74Insulin resistance_Homo sapiens_hsa049310.34305297
75Sphingolipid metabolism_Homo sapiens_hsa006000.34192210
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28957380
77Other glycan degradation_Homo sapiens_hsa005110.28809132
78Prion diseases_Homo sapiens_hsa050200.23780112
79Insulin secretion_Homo sapiens_hsa049110.23124377
80Glucagon signaling pathway_Homo sapiens_hsa049220.21662740
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.20824579
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20468008
83AMPK signaling pathway_Homo sapiens_hsa041520.19266286
84Pancreatic secretion_Homo sapiens_hsa049720.17550510
85Linoleic acid metabolism_Homo sapiens_hsa005910.17382876
86Serotonergic synapse_Homo sapiens_hsa047260.15466163
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10740411
88Circadian rhythm_Homo sapiens_hsa047100.10130272
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09288505
90Ovarian steroidogenesis_Homo sapiens_hsa049130.08262599
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04750359
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04456787
93Insulin signaling pathway_Homo sapiens_hsa049100.02009365
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.01093161
95* Arachidonic acid metabolism_Homo sapiens_hsa00590-0.2192604
96Hepatitis C_Homo sapiens_hsa05160-0.2140324
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1823791
98Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1792577
99Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1671509
100Regulation of autophagy_Homo sapiens_hsa04140-0.1659602
101Alzheimers disease_Homo sapiens_hsa05010-0.1597028
102Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1452741
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1440984
104Protein digestion and absorption_Homo sapiens_hsa04974-0.1430579
105Mineral absorption_Homo sapiens_hsa04978-0.1345250
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1254031
107Parkinsons disease_Homo sapiens_hsa05012-0.1099842
108Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1095913
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0892996
110Oxidative phosphorylation_Homo sapiens_hsa00190-0.0742445
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0679032
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0242581
113Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0039035

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