EPHX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.41532495
2daunorubicin metabolic process (GO:0044597)6.88836971
3polyketide metabolic process (GO:0030638)6.88836971
4doxorubicin metabolic process (GO:0044598)6.88836971
5establishment of skin barrier (GO:0061436)6.38592204
6sphingoid metabolic process (GO:0046519)5.73845009
7keratinization (GO:0031424)5.53180382
8regulation of water loss via skin (GO:0033561)5.48561340
9establishment of integrated proviral latency (GO:0075713)4.91855126
10sphingosine metabolic process (GO:0006670)4.69778511
11long-chain fatty acid biosynthetic process (GO:0042759)4.60030617
12regulation of gene silencing by RNA (GO:0060966)4.57316850
13regulation of posttranscriptional gene silencing (GO:0060147)4.57316850
14regulation of gene silencing by miRNA (GO:0060964)4.57316850
15detection of bacterium (GO:0016045)4.38539675
16diol metabolic process (GO:0034311)4.36735689
17keratinocyte proliferation (GO:0043616)4.29789731
18aminoglycoside antibiotic metabolic process (GO:0030647)4.24370426
19detection of other organism (GO:0098543)4.12724463
20chromatin remodeling at centromere (GO:0031055)4.10948074
21keratinocyte differentiation (GO:0030216)4.10570805
22detection of molecule of bacterial origin (GO:0032490)4.06348408
23L-serine metabolic process (GO:0006563)4.03553210
24CENP-A containing nucleosome assembly (GO:0034080)3.98943201
25detection of external biotic stimulus (GO:0098581)3.93425226
26gap junction assembly (GO:0016264)3.86091739
27positive regulation of interleukin-8 secretion (GO:2000484)3.84871295
28mitotic metaphase plate congression (GO:0007080)3.80371802
29paraxial mesoderm development (GO:0048339)3.77402083
30multicellular organismal water homeostasis (GO:0050891)3.73715499
31DNA replication checkpoint (GO:0000076)3.70572205
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.70325422
33regulation of mitotic spindle checkpoint (GO:1903504)3.70325422
34chaperone-mediated protein transport (GO:0072321)3.69009606
35proteasome assembly (GO:0043248)3.68577738
36establishment of viral latency (GO:0019043)3.68339381
37planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67986859
38regulation of cell fate specification (GO:0042659)3.62819187
39protein localization to kinetochore (GO:0034501)3.55874882
40linoleic acid metabolic process (GO:0043651)3.54649838
41regulation of cell proliferation involved in kidney development (GO:1901722)3.53748097
42protein complex localization (GO:0031503)3.51503179
43heterochromatin organization (GO:0070828)3.50382188
44response to pheromone (GO:0019236)3.49255742
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.48923152
46regulation of interleukin-8 secretion (GO:2000482)3.45481035
47polarized epithelial cell differentiation (GO:0030859)3.44245716
48glucosamine-containing compound catabolic process (GO:1901072)3.43307655
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.41644013
50keratinocyte development (GO:0003334)3.41386855
51DNA strand elongation involved in DNA replication (GO:0006271)3.40305524
52histone exchange (GO:0043486)3.31329109
53DNA replication-independent nucleosome assembly (GO:0006336)3.30892056
54DNA replication-independent nucleosome organization (GO:0034724)3.30892056
55regulation of helicase activity (GO:0051095)3.30397575
56detection of biotic stimulus (GO:0009595)3.28657336
57pre-miRNA processing (GO:0031054)3.22438224
58bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21038817
59DNA strand elongation (GO:0022616)3.20424386
60transcription elongation from RNA polymerase III promoter (GO:0006385)3.19839707
61termination of RNA polymerase III transcription (GO:0006386)3.19839707
62positive regulation of SMAD protein import into nucleus (GO:0060391)3.19558355
63limb bud formation (GO:0060174)3.19176832
64auditory receptor cell stereocilium organization (GO:0060088)3.17708336
65phosphatidylserine acyl-chain remodeling (GO:0036150)3.17601883
66IMP biosynthetic process (GO:0006188)3.17361457
67negative regulation of telomerase activity (GO:0051974)3.17100995
68negative regulation of keratinocyte proliferation (GO:0010839)3.16737279
69purine nucleobase biosynthetic process (GO:0009113)3.15818297
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15691140
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14857132
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14026778
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10679866
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10679866
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10679866
76negative regulation of mitotic sister chromatid separation (GO:2000816)3.10679866
77negative regulation of sister chromatid segregation (GO:0033046)3.10679866
78DNA damage response, detection of DNA damage (GO:0042769)3.09943312
79cellular protein complex localization (GO:0034629)3.09252329
80chemical homeostasis within a tissue (GO:0048875)3.08174026
81negative regulation of chromosome segregation (GO:0051985)3.07844445
82phosphatidylinositol acyl-chain remodeling (GO:0036149)3.07009475
83water homeostasis (GO:0030104)3.03311881
84G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.01560270
85metaphase plate congression (GO:0051310)3.01102930
86regulation of phospholipase A2 activity (GO:0032429)2.99144806
87telomere maintenance via semi-conservative replication (GO:0032201)2.98882952
88nodal signaling pathway (GO:0038092)2.97175221
89response to X-ray (GO:0010165)2.97163707
90epidermis development (GO:0008544)2.95953950
91L-alpha-amino acid transmembrane transport (GO:1902475)2.95814015
92inner ear receptor stereocilium organization (GO:0060122)2.95527799
93regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.95112449
94ceramide catabolic process (GO:0046514)2.94842678
95cellular anion homeostasis (GO:0030002)2.94205872
96negative regulation of cell fate commitment (GO:0010454)2.94014913
97molting cycle (GO:0042303)2.92922283
98hair cycle (GO:0042633)2.92922283
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92097030
100regulation of ruffle assembly (GO:1900027)2.91389256
101negative regulation of gene silencing (GO:0060969)2.91066226
102negative regulation of ligase activity (GO:0051352)2.90751744
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90751744
104nucleobase biosynthetic process (GO:0046112)2.90247599
105peptide cross-linking (GO:0018149)2.88321363
106epidermal cell differentiation (GO:0009913)2.87755933
107serine family amino acid biosynthetic process (GO:0009070)2.86279868
108spliceosomal snRNP assembly (GO:0000387)2.85953737
109positive regulation of uterine smooth muscle contraction (GO:0070474)2.84855328
110IMP metabolic process (GO:0046040)2.83023365
111mesonephros development (GO:0001823)2.82751153
112phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.81470918
113phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.81319652
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.81165284
115rRNA modification (GO:0000154)2.80699773
116negative regulation of mitosis (GO:0045839)2.80515560
117DNA unwinding involved in DNA replication (GO:0006268)2.80102372
118anterior/posterior axis specification, embryo (GO:0008595)2.79471527
119drinking behavior (GO:0042756)2.78750353
120superoxide anion generation (GO:0042554)2.77400195
121regulation of chemokine secretion (GO:0090196)2.76730651
122regulation of mitochondrial translation (GO:0070129)2.76573714
123spindle checkpoint (GO:0031577)2.76093273
124regulation of nuclear cell cycle DNA replication (GO:0033262)2.75934764
125regulation of cell fate commitment (GO:0010453)2.74291979
126regulation of spindle checkpoint (GO:0090231)2.71231870
127mesenchymal cell differentiation involved in renal system development (GO:2001012)2.71227169
128mesenchymal cell differentiation involved in kidney development (GO:0072161)2.71227169
129telomere maintenance via telomerase (GO:0007004)2.71137080
130regulation of mesoderm development (GO:2000380)2.70474387
131establishment of tissue polarity (GO:0007164)2.69895911
132establishment of planar polarity (GO:0001736)2.69895911
133cerebral cortex radially oriented cell migration (GO:0021799)2.69888417
134atrioventricular valve morphogenesis (GO:0003181)2.69353597
135mitotic spindle checkpoint (GO:0071174)2.68977757
136negative regulation of kidney development (GO:0090185)2.66030525
137negative regulation of stem cell proliferation (GO:2000647)2.64679762
138lateral sprouting from an epithelium (GO:0060601)2.61361955
139trivalent inorganic anion homeostasis (GO:0072506)2.56406715
140phosphate ion homeostasis (GO:0055062)2.56406715
141positive regulation of interleukin-1 beta secretion (GO:0050718)2.56015899
142presynaptic membrane assembly (GO:0097105)2.54791974
143negative regulation of T cell mediated immunity (GO:0002710)2.53759696
144intermediate filament organization (GO:0045109)2.51467175
145lipoxygenase pathway (GO:0019372)2.50806857
146negative regulation of axon guidance (GO:1902668)2.50776985
147cell proliferation involved in kidney development (GO:0072111)2.50414289
148negative regulation of homotypic cell-cell adhesion (GO:0034111)2.49509967
149surfactant homeostasis (GO:0043129)2.48564787
150sulfate transmembrane transport (GO:1902358)2.47749272
151CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.47465294
152T-helper cell differentiation (GO:0042093)2.47465294
153positive regulation of cellular amide metabolic process (GO:0034250)2.45712775
154cyclooxygenase pathway (GO:0019371)2.45063137
155presynaptic membrane organization (GO:0097090)2.44011991
156positive regulation of calcium ion import (GO:0090280)2.43926592
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.43478163
158extracellular negative regulation of signal transduction (GO:1900116)2.42555460
159extracellular regulation of signal transduction (GO:1900115)2.42555460
160positive regulation of monocyte chemotaxis (GO:0090026)2.41320186
161estrogen biosynthetic process (GO:0006703)2.41293828
162regulation of activation of Janus kinase activity (GO:0010533)2.41126683
163import into cell (GO:0098657)2.40574856
164facial nerve structural organization (GO:0021612)2.37110421
165regulation of somitogenesis (GO:0014807)2.35771317
166cell proliferation involved in metanephros development (GO:0072203)2.34367216
167sympathetic nervous system development (GO:0048485)2.33605464
168energy homeostasis (GO:0097009)2.33259309
169positive regulation of interleukin-1 secretion (GO:0050716)2.33198099
170negative regulation of cell fate specification (GO:0009996)2.32963758
171phospholipid scrambling (GO:0017121)2.31162710
172regulation of keratinocyte proliferation (GO:0010837)2.27534629
173prostate gland growth (GO:0060736)2.27224647
174regulation of glomerulus development (GO:0090192)2.26880039
175G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26695120
176kidney morphogenesis (GO:0060993)2.24656540
177regulation of timing of cell differentiation (GO:0048505)2.24540215
178sphingolipid biosynthetic process (GO:0030148)2.22583085
179neuron remodeling (GO:0016322)2.21821525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90188632
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.65762612
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01786105
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78276174
5GBX2_23144817_ChIP-Seq_PC3_Human3.32994440
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.09416461
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96647206
8EZH2_22144423_ChIP-Seq_EOC_Human2.85537552
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82542670
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.76243649
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.76243649
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.76243649
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75097619
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70329090
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.65889136
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63147531
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.58257019
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.50886238
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.47699132
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.45098464
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40426634
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36879434
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35622003
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.34697486
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34662367
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.30664864
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.29728306
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28527871
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.27745124
30BMI1_23680149_ChIP-Seq_NPCS_Mouse2.27173117
31JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24918395
32AR_21909140_ChIP-Seq_LNCAP_Human2.23041930
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20497374
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.15980911
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13344151
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08964321
37NANOG_16153702_ChIP-ChIP_HESCs_Human2.08937148
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08472432
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07716193
40VDR_22108803_ChIP-Seq_LS180_Human2.07115717
41TCF3_18692474_ChIP-Seq_MEFs_Mouse2.01608930
42CBX2_27304074_Chip-Seq_ESCs_Mouse2.00882285
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00604439
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98988562
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96990250
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94184146
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93522353
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87766277
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87766277
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87559491
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.85440350
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83639239
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81557380
54NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.81227173
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80520942
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.76179417
57TAF15_26573619_Chip-Seq_HEK293_Human1.74914322
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74493588
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73075981
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72632023
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72510422
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.71630701
63P300_19829295_ChIP-Seq_ESCs_Human1.70975702
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.70848169
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70647971
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.69060722
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67497475
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67454105
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67316067
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67298822
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67188539
72RNF2_27304074_Chip-Seq_NSC_Mouse1.66353837
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66292681
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59561136
75TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59192929
76TP53_18474530_ChIP-ChIP_U2OS_Human1.58668608
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.58474673
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57579601
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.57417249
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57218106
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.54664002
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54625340
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.51001955
84XRN2_22483619_ChIP-Seq_HELA_Human1.49656696
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49067271
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.48644152
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.48467828
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48066505
89* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47035445
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46708096
91TTF2_22483619_ChIP-Seq_HELA_Human1.45651937
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45469885
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44510561
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43624849
95SMAD4_21799915_ChIP-Seq_A2780_Human1.40844936
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.40579446
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.38221183
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.38052281
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37972931
100AR_21572438_ChIP-Seq_LNCaP_Human1.37414620
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37135183
102P53_22387025_ChIP-Seq_ESCs_Mouse1.35134148
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34496535
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34078149
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34020459
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33441736
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31900619
108CMYC_18555785_Chip-Seq_ESCs_Mouse1.30548654
109SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28907140
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28621814
111STAT3_18555785_Chip-Seq_ESCs_Mouse1.28250854
112ELK1_19687146_ChIP-ChIP_HELA_Human1.25712614
113NMYC_18555785_Chip-Seq_ESCs_Mouse1.24654886
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.24354039
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22998127
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22800495
117FOXP3_21729870_ChIP-Seq_TREG_Human1.22566819
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22546304
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.22105078
120SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21824126
121AR_25329375_ChIP-Seq_VCAP_Human1.21475023
122FUS_26573619_Chip-Seq_HEK293_Human1.20584418
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18924482
124CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18838161
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18570302
126DROSHA_22980978_ChIP-Seq_HELA_Human1.18557281
127OCT4_18555785_Chip-Seq_ESCs_Mouse1.18537307
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18153475
129SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17718320
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17507550
131CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17249773
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17118059
133SOX2_18555785_Chip-Seq_ESCs_Mouse1.17089740
134DCP1A_22483619_ChIP-Seq_HELA_Human1.15896988
135TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15114450
136RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14734625
137PU1_27457419_Chip-Seq_LIVER_Mouse1.12832751
138YY1_21170310_ChIP-Seq_MESCs_Mouse1.11228490
139P300_18555785_Chip-Seq_ESCs_Mouse1.11199769
140ARNT_22903824_ChIP-Seq_MCF-7_Human1.10791955
141GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.10698559
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10692400
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10570380
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10562191
145TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10562191
146RXR_22108803_ChIP-Seq_LS180_Human1.10342796
147TCF4_18268006_ChIP-ChIP_LS174T_Human1.09815186
148IGF1R_20145208_ChIP-Seq_DFB_Human1.09801953
149ZFX_18555785_Chip-Seq_ESCs_Mouse1.08914360
150P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07422776
151AHR_22903824_ChIP-Seq_MCF-7_Human1.07384505
152MYC_18940864_ChIP-ChIP_HL60_Human1.06936578
153NANOG_18692474_ChIP-Seq_MESCs_Mouse1.06879822
154TAL1_26923725_Chip-Seq_HPCs_Mouse1.06503003
155KLF4_18555785_Chip-Seq_ESCs_Mouse1.06398831
156EWS_26573619_Chip-Seq_HEK293_Human1.06348375
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06314237
158ER_23166858_ChIP-Seq_MCF-7_Human1.06213453
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06030434
160ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05730130
161ESRRB_18555785_Chip-Seq_ESCs_Mouse1.04870248
162KAP1_27257070_Chip-Seq_ESCs_Mouse1.04390862
163POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.04188395
164OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03583754
165CTCF_18555785_Chip-Seq_ESCs_Mouse1.03496388
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02527529
167RUNX2_22187159_ChIP-Seq_PCA_Human1.02323909
168GATA6_21074721_ChIP-Seq_CACO-2_Human1.00899459
169FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99769827
170TCF4_22108803_ChIP-Seq_LS180_Human0.99651008
171SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99616440
172POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99388915
173TP53_20018659_ChIP-ChIP_R1E_Mouse0.99346593
174SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98884985
175KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98613173
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96989530
177NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96952877
178GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96113107
179PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95396715
180ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94862498
181GABP_19822575_ChIP-Seq_HepG2_Human0.94136071
182FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87350288
183RBPJ_21746931_ChIP-Seq_IB4_Human0.86925116
184HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86421085
185RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86102454
186PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84350042
187STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83423142
188NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.83321931
189KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82729688
190GATA1_26923725_Chip-Seq_HPCs_Mouse0.80763138
191TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.80498223
192E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.78902977
193CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77996631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.70086018
2MP0000566_synostosis4.85518369
3MP0002796_impaired_skin_barrier4.84660899
4MP0004381_abnormal_hair_follicle3.74910469
5MP0005501_abnormal_skin_physiology3.06011909
6MP0002098_abnormal_vibrissa_morphology2.77193825
7MP0008004_abnormal_stomach_pH2.63891017
8MP0000383_abnormal_hair_follicle2.54886833
9MP0001188_hyperpigmentation2.54672072
10MP0004957_abnormal_blastocyst_morpholog2.52120821
11MP0005451_abnormal_body_composition2.50532268
12MP0003693_abnormal_embryo_hatching2.49491818
13MP0005275_abnormal_skin_tensile2.47593282
14MP0006292_abnormal_olfactory_placode2.47279871
15MP0001346_abnormal_lacrimal_gland2.44913672
16MP0000579_abnormal_nail_morphology2.44680725
17MP0002277_abnormal_respiratory_mucosa2.44069250
18MP0010771_integument_phenotype2.10635591
19MP0003136_yellow_coat_color2.09061132
20MP0010030_abnormal_orbit_morphology2.04388719
21MP0010094_abnormal_chromosome_stability2.00352766
22MP0002060_abnormal_skin_morphology1.96993740
23MP0001216_abnormal_epidermal_layer1.95561680
24MP0005171_absent_coat_pigmentation1.94177310
25MP0000647_abnormal_sebaceous_gland1.89670404
26MP0002102_abnormal_ear_morphology1.84466369
27MP0010678_abnormal_skin_adnexa1.82811064
28MP0003111_abnormal_nucleus_morphology1.81356482
29MP0000762_abnormal_tongue_morphology1.77967622
30MP0000467_abnormal_esophagus_morphology1.75727208
31MP0005645_abnormal_hypothalamus_physiol1.75632940
32MP0002009_preneoplasia1.70589052
33MP0008058_abnormal_DNA_repair1.69813822
34MP0003890_abnormal_embryonic-extraembry1.69510484
35MP0009672_abnormal_birth_weight1.66645142
36MP0003718_maternal_effect1.65464695
37MP0004742_abnormal_vestibular_system1.64077709
38MP0010352_gastrointestinal_tract_polyps1.63978182
39MP0005377_hearing/vestibular/ear_phenot1.62380753
40MP0003878_abnormal_ear_physiology1.62380753
41MP0008932_abnormal_embryonic_tissue1.60765187
42MP0010386_abnormal_urinary_bladder1.59096531
43MP0005646_abnormal_pituitary_gland1.58874713
44MP0000427_abnormal_hair_cycle1.55308062
45MP0004885_abnormal_endolymph1.54284421
46MP0003453_abnormal_keratinocyte_physiol1.53064789
47MP0004264_abnormal_extraembryonic_tissu1.44855516
48MP0003077_abnormal_cell_cycle1.39935621
49MP0000678_abnormal_parathyroid_gland1.39374211
50MP0002736_abnormal_nociception_after1.35012874
51MP0002132_abnormal_respiratory_system1.33958779
52MP0003880_abnormal_central_pattern1.32756064
53MP0002735_abnormal_chemical_nociception1.30989048
54MP0002111_abnormal_tail_morphology1.29952048
55MP0008057_abnormal_DNA_replication1.24330995
56MP0001293_anophthalmia1.23443889
57MP0002249_abnormal_larynx_morphology1.22243426
58MP0001968_abnormal_touch/_nociception1.22018381
59MP0005409_darkened_coat_color1.21440123
60MP0000377_abnormal_hair_follicle1.20027175
61MP0003937_abnormal_limbs/digits/tail_de1.19518268
62MP0002254_reproductive_system_inflammat1.18635023
63MP0008877_abnormal_DNA_methylation1.17518244
64MP0001984_abnormal_olfaction1.16440245
65MP0006276_abnormal_autonomic_nervous1.14534951
66MP0004782_abnormal_surfactant_physiolog1.14530311
67MP0002177_abnormal_outer_ear1.12960375
68MP0003011_delayed_dark_adaptation1.11054078
69MP0002163_abnormal_gland_morphology1.09979459
70MP0009697_abnormal_copulation1.09934443
71MP0001730_embryonic_growth_arrest1.09679289
72MP0009379_abnormal_foot_pigmentation1.09057813
73MP0003938_abnormal_ear_development1.08715024
74MP0004947_skin_inflammation1.08477558
75MP0001986_abnormal_taste_sensitivity1.07565783
76MP0005257_abnormal_intraocular_pressure1.04426185
77MP0003566_abnormal_cell_adhesion1.03374602
78MP0001486_abnormal_startle_reflex1.02386925
79MP0003567_abnormal_fetal_cardiomyocyte1.01556287
80MP0002085_abnormal_embryonic_tissue1.00193930
81MP0005423_abnormal_somatic_nervous1.00187133
82MP0003119_abnormal_digestive_system0.99218403
83MP0001191_abnormal_skin_condition0.97295589
84MP0002697_abnormal_eye_size0.96460472
85MP0003705_abnormal_hypodermis_morpholog0.95060194
86MP0001851_eye_inflammation0.94166750
87MP0005379_endocrine/exocrine_gland_phen0.93747916
88MP0008007_abnormal_cellular_replicative0.92506928
89MP0001485_abnormal_pinna_reflex0.92073257
90MP0000026_abnormal_inner_ear0.91978779
91MP0000350_abnormal_cell_proliferation0.91415597
92MP0008789_abnormal_olfactory_epithelium0.91341513
93MP0002084_abnormal_developmental_patter0.89884971
94MP0000613_abnormal_salivary_gland0.89111524
95MP0000516_abnormal_urinary_system0.88680752
96MP0005367_renal/urinary_system_phenotyp0.88680752
97MP0002638_abnormal_pupillary_reflex0.88043412
98MP0000049_abnormal_middle_ear0.86022474
99MP0009250_abnormal_appendicular_skeleto0.85592390
100MP0004133_heterotaxia0.84873882
101MP0005380_embryogenesis_phenotype0.84805548
102MP0001672_abnormal_embryogenesis/_devel0.84805548
103MP0005075_abnormal_melanosome_morpholog0.84633506
104MP0002148_abnormal_hypersensitivity_rea0.83302059
105MP0010234_abnormal_vibrissa_follicle0.83163733
106MP0002234_abnormal_pharynx_morphology0.82663737
107MP0004197_abnormal_fetal_growth/weight/0.82471116
108MP0001286_abnormal_eye_development0.82174346
109MP0002557_abnormal_social/conspecific_i0.81231195
110MP0003755_abnormal_palate_morphology0.80347906
111MP0009931_abnormal_skin_appearance0.78906716
112MP0000372_irregular_coat_pigmentation0.77907128
113MP0009703_decreased_birth_body0.77160857
114MP0001697_abnormal_embryo_size0.76966287
115MP0002876_abnormal_thyroid_physiology0.76449095
116MP0005394_taste/olfaction_phenotype0.74906300
117MP0005499_abnormal_olfactory_system0.74906300
118MP0004185_abnormal_adipocyte_glucose0.74685088
119MP0002095_abnormal_skin_pigmentation0.74614072
120MP0001177_atelectasis0.74309903
121MP0000367_abnormal_coat/_hair0.73890973
122MP0003724_increased_susceptibility_to0.71934962
123MP0006035_abnormal_mitochondrial_morpho0.71820690
124MP0005248_abnormal_Harderian_gland0.71657190
125MP0003315_abnormal_perineum_morphology0.69809632
126MP0009046_muscle_twitch0.69312530
127MP0003283_abnormal_digestive_organ0.68963277
128MP0003984_embryonic_growth_retardation0.68209278
129MP0002233_abnormal_nose_morphology0.68129019
130MP0002572_abnormal_emotion/affect_behav0.68098029
131MP0003879_abnormal_hair_cell0.67622207
132MP0001501_abnormal_sleep_pattern0.67149456
133MP0000681_abnormal_thyroid_gland0.66240506
134MP0009745_abnormal_behavioral_response0.65980943
135MP0004147_increased_porphyrin_level0.65975565
136MP0005508_abnormal_skeleton_morphology0.65484036
137MP0002080_prenatal_lethality0.65482866
138MP0000470_abnormal_stomach_morphology0.65466453
139MP0002184_abnormal_innervation0.64990998
140MP0001784_abnormal_fluid_regulation0.64655708
141MP0002088_abnormal_embryonic_growth/wei0.64438089
142MP0000015_abnormal_ear_pigmentation0.63928422
143MP0002938_white_spotting0.63909429
144MP0009053_abnormal_anal_canal0.63272178
145MP0000631_abnormal_neuroendocrine_gland0.62067493
146MP0001340_abnormal_eyelid_morphology0.62010311
147MP0000428_abnormal_craniofacial_morphol0.61420965
148MP0000538_abnormal_urinary_bladder0.61189546
149MP0000432_abnormal_head_morphology0.59816218
150MP0000465_gastrointestinal_hemorrhage0.59665386
151MP0001529_abnormal_vocalization0.58752583
152MP0001243_abnormal_dermal_layer0.58642544
153MP0008260_abnormal_autophagy0.58523615
154MP0001963_abnormal_hearing_physiology0.58444395
155MP0004043_abnormal_pH_regulation0.53687251
156MP0003186_abnormal_redox_activity0.51082404
157MP0002086_abnormal_extraembryonic_tissu0.50344886
158MP0001299_abnormal_eye_distance/0.49188357
159MP0003638_abnormal_response/metabolism_0.47786057
160MP0000627_abnormal_mammary_gland0.46173589
161MP0004019_abnormal_vitamin_homeostasis0.44867054

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)8.17763458
2Oral leukoplakia (HP:0002745)6.61334211
3Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.80775817
4Congenital ichthyosiform erythroderma (HP:0007431)4.39482744
5Lip pit (HP:0100267)4.37299572
6Erythroderma (HP:0001019)4.13157798
7Ectropion (HP:0000656)3.96960000
8Palmoplantar hyperkeratosis (HP:0000972)3.92655654
9Hypotrichosis (HP:0001006)3.92460963
10Palmar hyperkeratosis (HP:0010765)3.73198981
11Absent eyebrow (HP:0002223)3.72582785
12Popliteal pterygium (HP:0009756)3.71333032
13Abnormality of nail color (HP:0100643)3.70151916
14Plantar hyperkeratosis (HP:0007556)3.67502699
15Erythema (HP:0010783)3.62074085
16Selective tooth agenesis (HP:0001592)3.55406410
17Abnormality of the salivary glands (HP:0010286)3.49511066
18Alopecia of scalp (HP:0002293)3.47763478
19Follicular hyperkeratosis (HP:0007502)3.45455824
20Conjunctival hamartoma (HP:0100780)3.40540512
21Corneal erosion (HP:0200020)3.26116540
22Abnormality of the labia minora (HP:0012880)3.18795634
23Abnormality of secondary sexual hair (HP:0009888)3.18745894
24Abnormality of the axillary hair (HP:0100134)3.18745894
25Unilateral renal agenesis (HP:0000122)3.18381184
26Septo-optic dysplasia (HP:0100842)3.18186092
27Conical tooth (HP:0000698)3.11245612
28Hypohidrosis (HP:0000966)3.06606888
29Aplasia cutis congenita (HP:0001057)3.02461325
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92500685
31Pili torti (HP:0003777)2.91358550
32Woolly hair (HP:0002224)2.90929199
33Onycholysis (HP:0001806)2.87759428
34Increased IgE level (HP:0003212)2.81980357
35Duplicated collecting system (HP:0000081)2.80463975
36White forelock (HP:0002211)2.79012441
37Prostate neoplasm (HP:0100787)2.78969795
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.78612116
39Absent/shortened dynein arms (HP:0200106)2.78612116
40Patchy hypopigmentation of hair (HP:0011365)2.78405636
41Chronic bronchitis (HP:0004469)2.72438826
42Gangrene (HP:0100758)2.71608182
43Natal tooth (HP:0000695)2.71382660
44Abnormality of placental membranes (HP:0011409)2.69769081
45Amniotic constriction ring (HP:0009775)2.69769081
46Right ventricular cardiomyopathy (HP:0011663)2.66846957
47Abnormality of dental color (HP:0011073)2.64814890
48Corneal dystrophy (HP:0001131)2.61636945
49Recurrent corneal erosions (HP:0000495)2.58605782
50Birth length less than 3rd percentile (HP:0003561)2.58383039
51Maternal diabetes (HP:0009800)2.57136020
52Abnormality of the renal collecting system (HP:0004742)2.56960508
53Sparse eyelashes (HP:0000653)2.56672400
54Absent eyelashes (HP:0000561)2.51523957
55Colon cancer (HP:0003003)2.41746818
56Febrile seizures (HP:0002373)2.35043805
57Bilateral microphthalmos (HP:0007633)2.31284345
58Chromsome breakage (HP:0040012)2.30240633
59Pruritus (HP:0000989)2.29403215
60Abnormality of incisor morphology (HP:0011063)2.29030774
61Hypoplastic female external genitalia (HP:0012815)2.28196334
62Sparse scalp hair (HP:0002209)2.26711781
63Absent hair (HP:0002298)2.25018024
64Dry hair (HP:0011359)2.22527080
65Hyperphosphatemia (HP:0002905)2.20851281
66Breast hypoplasia (HP:0003187)2.19960878
67Abnormal ciliary motility (HP:0012262)2.19944038
68Cheilitis (HP:0100825)2.19857839
69Optic nerve hypoplasia (HP:0000609)2.18600846
70Hypoplastic labia majora (HP:0000059)2.18434209
71Labial hypoplasia (HP:0000066)2.16877045
72Optic neuritis (HP:0100653)2.16105318
73Retrobulbar optic neuritis (HP:0100654)2.16105318
74Furrowed tongue (HP:0000221)2.13831570
75Distal lower limb muscle weakness (HP:0009053)2.13777951
76Multiple enchondromatosis (HP:0005701)2.12825788
77Abnormality of the nasolacrimal system (HP:0000614)2.09271884
78Bilateral sensorineural hearing impairment (HP:0008619)2.08067418
79Brittle hair (HP:0002299)2.07466520
80Absent septum pellucidum (HP:0001331)2.06885742
81Upper limb muscle weakness (HP:0003484)2.06757082
82Renal dysplasia (HP:0000110)2.06498044
83Anhidrosis (HP:0000970)2.06458441
84Oligodontia (HP:0000677)2.04960749
85Advanced eruption of teeth (HP:0006288)2.04637237
86Thick nail (HP:0001805)2.04573437
87Abnormal hair laboratory examination (HP:0003328)2.03147478
88Alveolar cell carcinoma (HP:0006519)1.98910559
89Abnormality of the labia majora (HP:0012881)1.95879165
90Abnormal respiratory motile cilium physiology (HP:0012261)1.95181260
91Curly hair (HP:0002212)1.94345310
92Choanal stenosis (HP:0000452)1.94028748
93Congenital sensorineural hearing impairment (HP:0008527)1.93653714
94Osteomalacia (HP:0002749)1.92992744
95Multifactorial inheritance (HP:0001426)1.91956691
96Breast aplasia (HP:0100783)1.91775401
97Depressed nasal tip (HP:0000437)1.91172693
98Hypoglycemic seizures (HP:0002173)1.91103824
99Aplasia/Hypoplasia of the breasts (HP:0010311)1.90132700
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89042572
101Nasolacrimal duct obstruction (HP:0000579)1.88521620
102Congenital, generalized hypertrichosis (HP:0004540)1.86895164
103Abnormality of the preputium (HP:0100587)1.86885878
104Abnormal lung lobation (HP:0002101)1.86587570
105Abnormal respiratory epithelium morphology (HP:0012253)1.86355496
106Abnormal respiratory motile cilium morphology (HP:0005938)1.86355496
107Facial cleft (HP:0002006)1.83457168
108Neoplasm of the lung (HP:0100526)1.82884243
109Cupped ear (HP:0000378)1.82672662
110Slow-growing hair (HP:0002217)1.82585829
111Abnormality of hair growth rate (HP:0011363)1.82585829
112Orchitis (HP:0100796)1.82442569
113Meckel diverticulum (HP:0002245)1.82000603
114Amelogenesis imperfecta (HP:0000705)1.81042263
115Reticulocytopenia (HP:0001896)1.80987675
116Hypoparathyroidism (HP:0000829)1.80958167
117Ulnar claw (HP:0001178)1.78795995
118Hypergonadotropic hypogonadism (HP:0000815)1.78728846
119Hamartoma of the eye (HP:0010568)1.78586318
120Blepharitis (HP:0000498)1.77695217
121Focal motor seizures (HP:0011153)1.76935613
122Split foot (HP:0001839)1.76118587
123Stenosis of the external auditory canal (HP:0000402)1.76115986
124Non-midline cleft lip (HP:0100335)1.75182130
125Abnormality of homocysteine metabolism (HP:0010919)1.74302272
126Homocystinuria (HP:0002156)1.74302272
127Decreased central vision (HP:0007663)1.74260841
128Abnormality of the septum pellucidum (HP:0007375)1.74021815
129Morphological abnormality of the middle ear (HP:0008609)1.72909192
130Pustule (HP:0200039)1.72534068
131Abnormal blistering of the skin (HP:0008066)1.72414442
132Concave nail (HP:0001598)1.72352959
133Palmoplantar keratoderma (HP:0000982)1.71096447
134Renal agenesis (HP:0000104)1.70812018
135Nail dystrophy (HP:0008404)1.70714320
136Abnormality of the labia (HP:0000058)1.70577062
137Absent radius (HP:0003974)1.68883092
138Preauricular skin tag (HP:0000384)1.68629030
139Lack of skin elasticity (HP:0100679)1.67901167
140Tetany (HP:0001281)1.67625912
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67402215
142Partial duplication of thumb phalanx (HP:0009944)1.67209392
143Duplication of thumb phalanx (HP:0009942)1.66867414
144Abnormality of molar (HP:0011077)1.66296477
145Abnormality of molar morphology (HP:0011070)1.66296477
146Abnormality of the lacrimal duct (HP:0011481)1.65502017
147Hyperglycinuria (HP:0003108)1.65187112
148Fragile nails (HP:0001808)1.64875824
149Neoplasm of the tracheobronchial system (HP:0100552)1.64568202
150Abnormality of the ileum (HP:0001549)1.63991472
151Cellular immunodeficiency (HP:0005374)1.62775718
152Megaloblastic anemia (HP:0001889)1.61748575
153Abnormal number of erythroid precursors (HP:0012131)1.59009008
154Symptomatic seizures (HP:0011145)1.58958484
155Hyperglycinemia (HP:0002154)1.56426097
156Aplasia involving forearm bones (HP:0009822)1.56106079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.13633128
2CASK4.31867026
3VRK24.31451599
4BUB14.12189708
5PBK4.01473757
6CDC73.78531293
7TAF13.14180205
8TNIK2.89447218
9NME12.76072679
10TTK2.72584103
11SIK22.50996088
12MAP3K92.47532160
13TSSK62.33427064
14MAP3K142.12826688
15PLK32.09399274
16TNK22.07843894
17BLK1.95961427
18PRPF4B1.95734120
19EPHB21.94647139
20TGFBR11.91970418
21BMPR1B1.79798075
22MST41.78953625
23CDK191.75888079
24ZAK1.75085465
25INSRR1.72704845
26FGFR11.69042712
27TRIM281.68492615
28GRK11.68396487
29TXK1.67705393
30ADRBK21.65445743
31BCR1.64068739
32PLK41.63916462
33PNCK1.63242323
34PLK11.60397635
35CDK31.57378748
36EIF2AK21.54056067
37IRAK31.52342304
38STK241.50106957
39LATS11.49654353
40WEE11.47034215
41SIK11.44989206
42MAPKAPK31.44165570
43YES11.41229241
44GRK71.38754812
45MAP3K121.36712428
46FER1.35372339
47CDK81.35198795
48MAPK131.34982536
49MAP2K71.30945219
50NTRK21.27120816
51SMG11.24716455
52MKNK21.24228674
53DYRK31.24222421
54STK161.21853964
55IRAK41.19028783
56EPHA41.16857825
57WNK31.13926865
58LATS21.13414989
59MARK31.11161903
60PKN11.09499254
61TRPM71.09095014
62MST1R1.07852939
63EPHA21.07308914
64NEK11.06933602
65MAPKAPK51.04664364
66NME21.03545420
67BMPR20.99867733
68BMX0.99004125
69PIM20.98841362
70CHEK20.97654063
71NTRK30.96999384
72ERBB30.95557233
73PIK3CG0.95404521
74MAP3K30.95247461
75STK30.94861104
76MUSK0.93289166
77MAPK150.91811508
78CDK120.90604655
79IRAK10.90562468
80STK40.90550544
81AURKB0.89221498
82PAK40.88010102
83ATR0.86069043
84PRKCE0.85939769
85SGK20.83313330
86ACVR1B0.82840185
87CDK70.81203656
88STK38L0.78494331
89SRPK10.76975335
90IKBKE0.76933950
91BRD40.76321542
92MAP3K100.75509990
93NUAK10.75050867
94NEK60.74790113
95CHEK10.70923374
96RIPK40.70631306
97DMPK0.69726313
98BRSK20.69291605
99ALK0.68817153
100IRAK20.68535594
101ATM0.66999574
102MET0.65883085
103ADRBK10.65098613
104TEC0.62305311
105IKBKB0.61802433
106CAMK1G0.60551423
107MKNK10.60211357
108MYLK0.59997145
109NEK20.59378981
110TIE10.59142227
111TAOK20.59084708
112AURKA0.58610642
113RPS6KB20.58496272
114AKT30.57759983
115KIT0.56908373
116CSNK1E0.55984370
117CSNK1G10.55576527
118MAP3K80.53611650
119MARK20.53411446
120EPHA30.53184193
121PDK20.52442955
122CAMK10.52247290
123CAMK1D0.51894774
124MAP3K130.48687033
125SGK4940.48643858
126SGK2230.48643858
127OXSR10.48227415
128VRK10.48081599
129PASK0.46994543
130FGFR20.45124327
131NLK0.44911065
132PRKG10.44772888
133CSNK2A10.44557025
134CAMK2A0.43631799
135DYRK20.42938472
136PRKCQ0.41969306
137BRAF0.41471225
138MARK10.40495787
139CDK20.40278213
140PLK20.40246542
141KDR0.39508997
142SGK10.39234479
143CDK10.39061039
144MAP3K60.38211721
145PIM10.38088032
146EIF2AK30.37930257
147SYK0.35843184
148MAPK70.35745448
149PRKDC0.35538562
150CSNK2A20.35342942
151ERBB40.34837926
152TGFBR20.34594776
153FGR0.34387373
154GRK50.33894102
155PRKCG0.33560188
156CSNK1D0.32328374
157DYRK1A0.32233241
158LYN0.31394269
159FES0.30393849
160CSNK1G20.29592725
161HCK0.29460555
162ITK0.28416208
163PRKACA0.27272011
164PAK10.26240708
165EIF2AK10.25275907
166PTK20.25053867
167CSNK1A10.22037562
168BRSK10.21833297
169PRKCI0.20951794

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.64616101
2DNA replication_Homo sapiens_hsa030303.49251193
3Mismatch repair_Homo sapiens_hsa034303.43959903
4Sphingolipid metabolism_Homo sapiens_hsa006003.05474827
5Ribosome_Homo sapiens_hsa030102.98617629
6RNA polymerase_Homo sapiens_hsa030202.91590622
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86195976
8Spliceosome_Homo sapiens_hsa030402.53149337
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.42756018
10Nicotine addiction_Homo sapiens_hsa050332.38012980
11Homologous recombination_Homo sapiens_hsa034402.32032332
12Base excision repair_Homo sapiens_hsa034102.11608424
13Oxidative phosphorylation_Homo sapiens_hsa001902.04403624
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03705025
15RNA transport_Homo sapiens_hsa030132.03660613
16Arachidonic acid metabolism_Homo sapiens_hsa005902.01636875
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.98011193
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88011361
19Cell cycle_Homo sapiens_hsa041101.86957382
20Parkinsons disease_Homo sapiens_hsa050121.84082147
21One carbon pool by folate_Homo sapiens_hsa006701.80639514
22Serotonergic synapse_Homo sapiens_hsa047261.80453114
23Axon guidance_Homo sapiens_hsa043601.70637495
24Non-homologous end-joining_Homo sapiens_hsa034501.69570254
25Linoleic acid metabolism_Homo sapiens_hsa005911.68423075
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67723048
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.65574507
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.64948252
29Huntingtons disease_Homo sapiens_hsa050161.62092113
30Ether lipid metabolism_Homo sapiens_hsa005651.60930900
31Steroid biosynthesis_Homo sapiens_hsa001001.60760577
32Taste transduction_Homo sapiens_hsa047421.57643397
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57575718
34Vitamin digestion and absorption_Homo sapiens_hsa049771.56633372
35Graft-versus-host disease_Homo sapiens_hsa053321.54831322
36Phototransduction_Homo sapiens_hsa047441.54709669
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53657614
38Selenocompound metabolism_Homo sapiens_hsa004501.50958318
39RNA degradation_Homo sapiens_hsa030181.45571169
40mRNA surveillance pathway_Homo sapiens_hsa030151.44705947
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40700179
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40566586
43Pyruvate metabolism_Homo sapiens_hsa006201.39537012
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39024535
45Rheumatoid arthritis_Homo sapiens_hsa053231.37862516
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36950791
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.36242927
48Basal transcription factors_Homo sapiens_hsa030221.35152288
49Autoimmune thyroid disease_Homo sapiens_hsa053201.33809125
50Pyrimidine metabolism_Homo sapiens_hsa002401.32982306
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30402749
52Morphine addiction_Homo sapiens_hsa050321.28230537
53Nucleotide excision repair_Homo sapiens_hsa034201.26180553
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23870953
55Calcium signaling pathway_Homo sapiens_hsa040201.23733262
56Folate biosynthesis_Homo sapiens_hsa007901.23455976
57Biosynthesis of amino acids_Homo sapiens_hsa012301.20391810
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18867903
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18054040
60Hematopoietic cell lineage_Homo sapiens_hsa046401.17632253
61Alzheimers disease_Homo sapiens_hsa050101.16078540
62Protein export_Homo sapiens_hsa030601.14354433
63Glutamatergic synapse_Homo sapiens_hsa047241.13606515
64Primary immunodeficiency_Homo sapiens_hsa053401.13154540
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09897522
66Allograft rejection_Homo sapiens_hsa053301.07291593
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.07143666
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05743386
69Vitamin B6 metabolism_Homo sapiens_hsa007501.05257131
70Ras signaling pathway_Homo sapiens_hsa040141.05049361
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05023708
72Circadian entrainment_Homo sapiens_hsa047131.04941963
73Collecting duct acid secretion_Homo sapiens_hsa049661.04674633
74Intestinal immune network for IgA production_Homo sapiens_hsa046721.04366221
75Fatty acid elongation_Homo sapiens_hsa000621.02975305
76Melanoma_Homo sapiens_hsa052181.02342186
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01542176
78Basal cell carcinoma_Homo sapiens_hsa052170.98619474
79Olfactory transduction_Homo sapiens_hsa047400.97677402
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96210294
81Renin secretion_Homo sapiens_hsa049240.96166819
82Glutathione metabolism_Homo sapiens_hsa004800.95948003
83p53 signaling pathway_Homo sapiens_hsa041150.95826505
84Long-term depression_Homo sapiens_hsa047300.95554207
85Mineral absorption_Homo sapiens_hsa049780.94238166
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92685839
87Oocyte meiosis_Homo sapiens_hsa041140.90539502
88Ovarian steroidogenesis_Homo sapiens_hsa049130.90365357
89Fanconi anemia pathway_Homo sapiens_hsa034600.88085639
90Purine metabolism_Homo sapiens_hsa002300.87788642
91African trypanosomiasis_Homo sapiens_hsa051430.85205637
92Wnt signaling pathway_Homo sapiens_hsa043100.82744575
93Tight junction_Homo sapiens_hsa045300.82110112
94Measles_Homo sapiens_hsa051620.81851818
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79021787
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79001844
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.78180461
98Propanoate metabolism_Homo sapiens_hsa006400.77857896
99GABAergic synapse_Homo sapiens_hsa047270.77750684
100ErbB signaling pathway_Homo sapiens_hsa040120.74907740
101Asthma_Homo sapiens_hsa053100.74602820
102Carbon metabolism_Homo sapiens_hsa012000.74120741
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.73679877
104Malaria_Homo sapiens_hsa051440.72288032
105Cardiac muscle contraction_Homo sapiens_hsa042600.72120488
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71775740
107Phagosome_Homo sapiens_hsa041450.71040151
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70349367
109beta-Alanine metabolism_Homo sapiens_hsa004100.69722916
110Histidine metabolism_Homo sapiens_hsa003400.68457916
111Arginine and proline metabolism_Homo sapiens_hsa003300.68223924
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.68057825
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67660861
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66058560
115Retinol metabolism_Homo sapiens_hsa008300.65490529
116Thyroid cancer_Homo sapiens_hsa052160.65406398
117Salivary secretion_Homo sapiens_hsa049700.64348478
118ECM-receptor interaction_Homo sapiens_hsa045120.63675134
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63608448
120Fat digestion and absorption_Homo sapiens_hsa049750.62999810
121cAMP signaling pathway_Homo sapiens_hsa040240.62299274
122Notch signaling pathway_Homo sapiens_hsa043300.62293356
123TNF signaling pathway_Homo sapiens_hsa046680.61781741
124Metabolic pathways_Homo sapiens_hsa011000.60679908
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60625577
126Regulation of autophagy_Homo sapiens_hsa041400.60426119
127Staphylococcus aureus infection_Homo sapiens_hsa051500.59173429
128Phenylalanine metabolism_Homo sapiens_hsa003600.58676630
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58607975
130Circadian rhythm_Homo sapiens_hsa047100.58563238
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58355801
132Other glycan degradation_Homo sapiens_hsa005110.58270835
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57972007
134ABC transporters_Homo sapiens_hsa020100.57570009
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57457988
136MAPK signaling pathway_Homo sapiens_hsa040100.56774253
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56228022
138Pertussis_Homo sapiens_hsa051330.55293086
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53380222
140T cell receptor signaling pathway_Homo sapiens_hsa046600.53257406
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53222362
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53032276
143Tuberculosis_Homo sapiens_hsa051520.51865423
144Oxytocin signaling pathway_Homo sapiens_hsa049210.51744152
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50539424
146TGF-beta signaling pathway_Homo sapiens_hsa043500.49559355
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49474671
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.49238566
149Leishmaniasis_Homo sapiens_hsa051400.48256217
150Synaptic vesicle cycle_Homo sapiens_hsa047210.47952117
151Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47809934
152Rap1 signaling pathway_Homo sapiens_hsa040150.47752374
153Amphetamine addiction_Homo sapiens_hsa050310.47625965
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46427846
155Hepatitis C_Homo sapiens_hsa051600.46427547
156Hippo signaling pathway_Homo sapiens_hsa043900.44459740
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43470289
158Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42911430
159Adherens junction_Homo sapiens_hsa045200.42610653
160Hedgehog signaling pathway_Homo sapiens_hsa043400.42409742
161Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42309243
162Osteoclast differentiation_Homo sapiens_hsa043800.41569498
163MicroRNAs in cancer_Homo sapiens_hsa052060.41453872
164Arginine biosynthesis_Homo sapiens_hsa002200.40384054
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40035188
166Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39846977
167Galactose metabolism_Homo sapiens_hsa000520.39355468
168Fatty acid degradation_Homo sapiens_hsa000710.36502202
169Cyanoamino acid metabolism_Homo sapiens_hsa004600.34291378
170Fatty acid metabolism_Homo sapiens_hsa012120.31060499
171Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29592045
172Tyrosine metabolism_Homo sapiens_hsa003500.27288191
173Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24216974
174Epstein-Barr virus infection_Homo sapiens_hsa051690.23066435
175Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21430843

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