EPHX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.96314530
2glutamate secretion (GO:0014047)5.83799237
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.82792837
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68422620
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38845779
6regulation of synaptic vesicle exocytosis (GO:2000300)5.28717150
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21877625
8vocalization behavior (GO:0071625)5.16610914
9protein localization to synapse (GO:0035418)5.11933562
10neuronal action potential propagation (GO:0019227)4.92050430
11regulation of glutamate receptor signaling pathway (GO:1900449)4.89751543
12neuron cell-cell adhesion (GO:0007158)4.88385629
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.78663220
14regulation of synaptic vesicle transport (GO:1902803)4.74088825
15synaptic vesicle maturation (GO:0016188)4.72136473
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58396518
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.50336281
18behavioral response to nicotine (GO:0035095)4.47822231
19fucose catabolic process (GO:0019317)4.39958840
20L-fucose metabolic process (GO:0042354)4.39958840
21L-fucose catabolic process (GO:0042355)4.39958840
22locomotory exploration behavior (GO:0035641)4.38642126
23glutamate receptor signaling pathway (GO:0007215)4.34609742
24synaptic transmission, glutamatergic (GO:0035249)4.34410360
25neuron-neuron synaptic transmission (GO:0007270)4.33511995
26presynaptic membrane assembly (GO:0097105)4.32187564
27negative regulation of synaptic transmission, GABAergic (GO:0032229)4.31239884
28DNA deamination (GO:0045006)4.20872818
29gamma-aminobutyric acid signaling pathway (GO:0007214)4.17909735
30long-term synaptic potentiation (GO:0060291)4.13095446
31neurotransmitter-gated ion channel clustering (GO:0072578)4.12966016
32regulation of long-term neuronal synaptic plasticity (GO:0048169)4.09568910
33neurotransmitter secretion (GO:0007269)4.04655428
34presynaptic membrane organization (GO:0097090)4.03197084
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.95968309
36regulation of neuronal synaptic plasticity (GO:0048168)3.94747328
37positive regulation of neurotransmitter secretion (GO:0001956)3.86478512
38sensory perception of smell (GO:0007608)3.83098700
39regulation of synaptic plasticity (GO:0048167)3.81183229
40behavioral response to cocaine (GO:0048148)3.79600847
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77874109
42regulation of postsynaptic membrane potential (GO:0060078)3.74836757
43positive regulation of neurotransmitter transport (GO:0051590)3.74044159
44response to histamine (GO:0034776)3.68764274
45response to pheromone (GO:0019236)3.68177983
46positive regulation of synapse maturation (GO:0090129)3.67770303
47exploration behavior (GO:0035640)3.67507825
48ATP hydrolysis coupled proton transport (GO:0015991)3.64869401
49energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.64869401
50positive regulation of membrane potential (GO:0045838)3.63991436
51postsynaptic membrane organization (GO:0001941)3.63035408
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.62404115
53synaptic vesicle endocytosis (GO:0048488)3.60843330
54regulation of neurotransmitter secretion (GO:0046928)3.59542876
55transferrin transport (GO:0033572)3.56404590
56neuron recognition (GO:0008038)3.54369797
57activation of protein kinase A activity (GO:0034199)3.51306453
58protein localization to cilium (GO:0061512)3.45289382
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43222761
60C4-dicarboxylate transport (GO:0015740)3.42920582
61piRNA metabolic process (GO:0034587)3.42183774
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.41771149
63heart field specification (GO:0003128)3.41685366
64secondary heart field specification (GO:0003139)3.41685366
65regulation of glutamate secretion (GO:0014048)3.40072040
66detection of calcium ion (GO:0005513)3.38089044
67long-term memory (GO:0007616)3.37536469
68water-soluble vitamin biosynthetic process (GO:0042364)3.36801515
69regulation of synapse structural plasticity (GO:0051823)3.35989565
70regulation of dendritic spine morphogenesis (GO:0061001)3.32706751
71ferric iron transport (GO:0015682)3.29974693
72trivalent inorganic cation transport (GO:0072512)3.29974693
73preassembly of GPI anchor in ER membrane (GO:0016254)3.29495270
74regulation of neurotransmitter transport (GO:0051588)3.28709433
75proline transport (GO:0015824)3.28585194
76neurotransmitter transport (GO:0006836)3.28381774
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28070453
78platelet dense granule organization (GO:0060155)3.26841459
79regulation of voltage-gated calcium channel activity (GO:1901385)3.26370795
80negative regulation of telomere maintenance (GO:0032205)3.26045212
81negative regulation of dendrite morphogenesis (GO:0050774)3.25027602
82axonal fasciculation (GO:0007413)3.24646260
83behavioral defense response (GO:0002209)3.23433032
84behavioral fear response (GO:0001662)3.23433032
85regulation of vesicle fusion (GO:0031338)3.21578288
86cerebellar Purkinje cell differentiation (GO:0021702)3.20051843
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18793380
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.18793380
89NADH dehydrogenase complex assembly (GO:0010257)3.18793380
90long term synaptic depression (GO:0060292)3.16684896
91membrane depolarization (GO:0051899)3.16672944
92chaperone-mediated protein transport (GO:0072321)3.13804254
93cerebellar granule cell differentiation (GO:0021707)3.12984718
94positive regulation of synaptic transmission (GO:0050806)3.12362935
95fear response (GO:0042596)3.10885086
96protein complex biogenesis (GO:0070271)3.08487334
97regulation of synaptic transmission (GO:0050804)3.08454916
98synaptic transmission (GO:0007268)3.07866104
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07099744
100mechanosensory behavior (GO:0007638)3.04930619
101gamma-aminobutyric acid transport (GO:0015812)3.04490670
102regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04075580
103primary amino compound metabolic process (GO:1901160)3.03510091
104cellular potassium ion homeostasis (GO:0030007)3.03026218
105mitochondrial respiratory chain complex assembly (GO:0033108)3.02919596
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02407840
107female mating behavior (GO:0060180)3.02279905
108regulation of dendritic spine development (GO:0060998)3.01726547
109regulation of neurotransmitter levels (GO:0001505)3.00043436
110protein K11-linked deubiquitination (GO:0035871)2.99917862
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98028065
112transcription elongation from RNA polymerase III promoter (GO:0006385)2.95830317
113termination of RNA polymerase III transcription (GO:0006386)2.95830317
114membrane depolarization during action potential (GO:0086010)2.95564502
115establishment of protein localization to mitochondrial membrane (GO:0090151)2.95469461
116regulation of synapse maturation (GO:0090128)2.94560834
117regulation of mesoderm development (GO:2000380)2.94149932
118negative regulation of dendrite development (GO:2000171)2.93531872
119regulation of female receptivity (GO:0045924)2.92967487
120serotonin metabolic process (GO:0042428)2.92914592
121dendritic spine morphogenesis (GO:0060997)2.92538122
122startle response (GO:0001964)2.92261372
123synaptic vesicle transport (GO:0048489)2.91924993
124establishment of synaptic vesicle localization (GO:0097480)2.91924993
125layer formation in cerebral cortex (GO:0021819)2.90960769
126learning (GO:0007612)2.89696055
127mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89653982
128transmission of nerve impulse (GO:0019226)2.89571279
129cellular response to ATP (GO:0071318)2.89541617
130calcium ion-dependent exocytosis (GO:0017156)2.89012450
131pseudouridine synthesis (GO:0001522)2.84790589
132protein deneddylation (GO:0000338)2.80787580
133somite rostral/caudal axis specification (GO:0032525)2.80413160
134sleep (GO:0030431)2.79000797
135protein-cofactor linkage (GO:0018065)2.78506329
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77459157
137cullin deneddylation (GO:0010388)2.77086799
138sulfation (GO:0051923)2.75054571
139intracellular protein transmembrane import (GO:0044743)2.71002403
140adaptation of signaling pathway (GO:0023058)2.69102473
141axon ensheathment in central nervous system (GO:0032291)2.67642021
142central nervous system myelination (GO:0022010)2.67642021
143negative regulation of cytosolic calcium ion concentration (GO:0051481)2.67161391
144DNA methylation involved in gamete generation (GO:0043046)2.60642256
145detection of light stimulus involved in sensory perception (GO:0050962)2.52414124
146detection of light stimulus involved in visual perception (GO:0050908)2.52414124
147ubiquinone biosynthetic process (GO:0006744)2.50833163
148respiratory chain complex IV assembly (GO:0008535)2.49849491
149detection of mechanical stimulus involved in sensory perception (GO:0050974)2.46869550
150energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44806380
151ATP synthesis coupled proton transport (GO:0015986)2.44806380
152cell migration involved in gastrulation (GO:0042074)2.42817290
153auditory receptor cell stereocilium organization (GO:0060088)2.42127909
154retinal cone cell development (GO:0046549)2.41999839
155neuronal action potential (GO:0019228)2.41676767
156reflex (GO:0060004)2.41528403
157serotonin receptor signaling pathway (GO:0007210)2.40167444
158cardiac ventricle formation (GO:0003211)2.39245692
159nucleotide transmembrane transport (GO:1901679)2.38335409
160glycerophospholipid catabolic process (GO:0046475)2.37358552
161cellular anion homeostasis (GO:0030002)2.36776811
162positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.36416937
163adult feeding behavior (GO:0008343)2.35700576
164phosphorelay signal transduction system (GO:0000160)2.35376087
165regulation of sensory perception of pain (GO:0051930)2.34842151
166regulation of sensory perception (GO:0051931)2.34842151
167mannosylation (GO:0097502)2.32068379
168glycosphingolipid biosynthetic process (GO:0006688)2.31224349
169male meiosis I (GO:0007141)2.31199482
170positive regulation of cell fate commitment (GO:0010455)2.30989030
171purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.30534094
1723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.30534094
173positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.30172265
174ubiquinone metabolic process (GO:0006743)2.29620249
175electron transport chain (GO:0022900)2.29424863
176positive regulation of sodium ion transmembrane transport (GO:1902307)2.28880976
177dopamine transport (GO:0015872)2.28725005
178rhodopsin mediated signaling pathway (GO:0016056)2.27224237
179kynurenine metabolic process (GO:0070189)2.26276742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31339107
2GBX2_23144817_ChIP-Seq_PC3_Human4.54700430
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17881329
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03697100
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01966603
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74480410
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72182951
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.63488476
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.63488476
10TAF15_26573619_Chip-Seq_HEK293_Human2.62836849
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56519879
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.53615914
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49807997
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47920617
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44770140
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42353589
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.40573018
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40533083
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.29356835
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.23616965
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23408142
22DROSHA_22980978_ChIP-Seq_HELA_Human2.20020089
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.19361971
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19130647
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12415585
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12218765
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08677193
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08562036
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05935045
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.00835091
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.98072049
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97697310
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89412350
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.89161852
35SMAD4_21799915_ChIP-Seq_A2780_Human1.88720642
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84902554
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.82834351
38P300_19829295_ChIP-Seq_ESCs_Human1.79771594
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76891288
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71366202
41VDR_22108803_ChIP-Seq_LS180_Human1.70239793
42EWS_26573619_Chip-Seq_HEK293_Human1.67821415
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67603177
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.64179969
45AR_21572438_ChIP-Seq_LNCaP_Human1.62163064
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60717933
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60190680
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60169097
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57942056
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55453017
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55335803
52FUS_26573619_Chip-Seq_HEK293_Human1.54576970
53TP53_22573176_ChIP-Seq_HFKS_Human1.52512573
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.52115639
55MYC_18940864_ChIP-ChIP_HL60_Human1.51775989
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.51074982
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50172817
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48174917
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48110759
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47948479
61SALL1_21062744_ChIP-ChIP_HESCs_Human1.45965945
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38836183
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.38494713
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35815281
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.34770534
66AR_25329375_ChIP-Seq_VCAP_Human1.34322418
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33945146
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.33049026
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31805416
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31540923
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.29984126
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29259752
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.28888643
74FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28888643
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.28717709
76RNF2_27304074_Chip-Seq_NSC_Mouse1.26941289
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26457994
78TCF4_22108803_ChIP-Seq_LS180_Human1.26160768
79STAT3_23295773_ChIP-Seq_U87_Human1.22789747
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22115653
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.21648885
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20303986
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.19840439
84IRF1_19129219_ChIP-ChIP_H3396_Human1.19193995
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.18498679
86NANOG_19829295_ChIP-Seq_ESCs_Human1.17953097
87SOX2_19829295_ChIP-Seq_ESCs_Human1.17953097
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17210606
89TCF4_23295773_ChIP-Seq_U87_Human1.17039876
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15377808
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15237169
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14767422
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.13964649
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13741948
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13594078
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12946248
97ELK1_19687146_ChIP-ChIP_HELA_Human1.11178879
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10507728
99CBP_20019798_ChIP-Seq_JUKART_Human1.10507728
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.09962070
101ZNF274_21170338_ChIP-Seq_K562_Hela1.09960506
102LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09820537
103ER_23166858_ChIP-Seq_MCF-7_Human1.09474146
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.09221873
105JUN_21703547_ChIP-Seq_K562_Human1.08950899
106RUNX2_22187159_ChIP-Seq_PCA_Human1.08731091
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07692848
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07541279
109AHR_22903824_ChIP-Seq_MCF-7_Human1.07418145
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07073824
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.06938047
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.06801677
113AR_19668381_ChIP-Seq_PC3_Human1.06046260
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.05935075
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04399346
116HOXB7_26014856_ChIP-Seq_BT474_Human1.02893076
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01875657
118NCOR_22424771_ChIP-Seq_293T_Human1.00752813
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.00706115
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00703210
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00613851
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00613851
123KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00459252
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.00431895
125SRF_21415370_ChIP-Seq_HL-1_Mouse1.00367480
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.00210107
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98067118
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97131933
129BCAT_22108803_ChIP-Seq_LS180_Human0.96785400
130TP53_18474530_ChIP-ChIP_U2OS_Human0.96275689
131YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96250394
132IGF1R_20145208_ChIP-Seq_DFB_Human0.95776265
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95294576
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94727063
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93925342
136WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92655818
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.92343296
138SOX9_26525672_Chip-Seq_HEART_Mouse0.91857569
139KDM2B_26808549_Chip-Seq_REH_Human0.90847328
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88117226
141E2F1_18555785_Chip-Seq_ESCs_Mouse0.87123138
142P53_22387025_ChIP-Seq_ESCs_Mouse0.86350028
143BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86348345
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86342728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25060174
2MP0003880_abnormal_central_pattern5.77700025
3MP0003635_abnormal_synaptic_transmissio4.13349549
4MP0001984_abnormal_olfaction3.68662572
5MP0004270_analgesia3.65292831
6MP0009745_abnormal_behavioral_response3.48445994
7MP0002063_abnormal_learning/memory/cond3.36322497
8MP0001968_abnormal_touch/_nociception3.32553986
9MP0002064_seizures3.30205674
10MP0009046_muscle_twitch3.09570999
11MP0002234_abnormal_pharynx_morphology3.00780172
12MP0002572_abnormal_emotion/affect_behav2.97423305
13MP0002736_abnormal_nociception_after2.93057019
14MP0002272_abnormal_nervous_system2.75430148
15MP0002734_abnormal_mechanical_nocicepti2.57918743
16MP0001486_abnormal_startle_reflex2.50513856
17MP0001501_abnormal_sleep_pattern2.38167664
18MP0002822_catalepsy2.33081844
19MP0001986_abnormal_taste_sensitivity2.32243900
20MP0001440_abnormal_grooming_behavior2.28654303
21MP0002735_abnormal_chemical_nociception2.26658073
22MP0008875_abnormal_xenobiotic_pharmacok2.12002915
23MP0002067_abnormal_sensory_capabilities2.06831060
24MP0003879_abnormal_hair_cell1.94570667
25MP0009780_abnormal_chondrocyte_physiolo1.91602756
26MP0001970_abnormal_pain_threshold1.89445147
27MP0002733_abnormal_thermal_nociception1.81973807
28MP0006072_abnormal_retinal_apoptosis1.79626405
29MP0002184_abnormal_innervation1.78625492
30MP0002837_dystrophic_cardiac_calcinosis1.75202142
31MP0003329_amyloid_beta_deposits1.75195267
32MP0005646_abnormal_pituitary_gland1.74100154
33MP0002102_abnormal_ear_morphology1.73676672
34MP0005423_abnormal_somatic_nervous1.70765222
35MP0004924_abnormal_behavior1.69104851
36MP0005386_behavior/neurological_phenoty1.69104851
37MP0001529_abnormal_vocalization1.67819225
38MP0004147_increased_porphyrin_level1.67438192
39MP0002557_abnormal_social/conspecific_i1.66714788
40MP0000778_abnormal_nervous_system1.65861902
41MP0008569_lethality_at_weaning1.65040722
42MP0006292_abnormal_olfactory_placode1.62119932
43MP0004811_abnormal_neuron_physiology1.59423228
44MP0003787_abnormal_imprinting1.58892042
45MP0005253_abnormal_eye_physiology1.53978343
46MP0002160_abnormal_reproductive_system1.53288302
47MP0006276_abnormal_autonomic_nervous1.50107771
48MP0000427_abnormal_hair_cycle1.47450284
49MP0001905_abnormal_dopamine_level1.42831292
50MP0002638_abnormal_pupillary_reflex1.42801911
51MP0002909_abnormal_adrenal_gland1.41717092
52MP0002876_abnormal_thyroid_physiology1.39352320
53MP0000569_abnormal_digit_pigmentation1.38445537
54MP0003195_calcinosis1.36938319
55MP0002066_abnormal_motor_capabilities/c1.35720935
56MP0001188_hyperpigmentation1.34310733
57MP0002882_abnormal_neuron_morphology1.34250962
58MP0005389_reproductive_system_phenotype1.32877067
59MP0001919_abnormal_reproductive_system1.29673333
60MP0000955_abnormal_spinal_cord1.29344052
61MP0004858_abnormal_nervous_system1.23085742
62MP0003633_abnormal_nervous_system1.20926827
63MP0002163_abnormal_gland_morphology1.20502542
64MP0004142_abnormal_muscle_tone1.18769238
65MP0003136_yellow_coat_color1.18206238
66MP0001502_abnormal_circadian_rhythm1.17939988
67MP0005379_endocrine/exocrine_gland_phen1.14827044
68MP0003122_maternal_imprinting1.10858262
69MP0001485_abnormal_pinna_reflex1.10022550
70MP0000013_abnormal_adipose_tissue1.09733274
71MP0005394_taste/olfaction_phenotype1.04932711
72MP0005499_abnormal_olfactory_system1.04932711
73MP0000751_myopathy1.04809812
74MP0002938_white_spotting1.04738774
75MP0005645_abnormal_hypothalamus_physiol1.03372453
76MP0003631_nervous_system_phenotype1.03343624
77MP0010386_abnormal_urinary_bladder1.01920546
78MP0002152_abnormal_brain_morphology1.01501254
79MP0003718_maternal_effect1.01042689
80MP0001963_abnormal_hearing_physiology0.98568450
81MP0008874_decreased_physiological_sensi0.98060871
82MP0002751_abnormal_autonomic_nervous0.97314521
83MP0008872_abnormal_physiological_respon0.97080097
84MP0002229_neurodegeneration0.93140978
85MP0004145_abnormal_muscle_electrophysio0.91514607
86MP0008058_abnormal_DNA_repair0.91024852
87MP0005195_abnormal_posterior_eye0.90255080
88MP0002069_abnormal_eating/drinking_beha0.87859417
89MP0004484_altered_response_of0.87851009
90MP0005551_abnormal_eye_electrophysiolog0.86215691
91MP0005535_abnormal_body_temperature0.85385619
92MP0001664_abnormal_digestion0.85191564
93MP0002210_abnormal_sex_determination0.84543687
94MP0004742_abnormal_vestibular_system0.84087534
95MP0003698_abnormal_male_reproductive0.83469397
96MP0004215_abnormal_myocardial_fiber0.81990739
97MP0004133_heterotaxia0.81982218
98MP0000647_abnormal_sebaceous_gland0.81371187
99MP0004885_abnormal_endolymph0.81317431
100MP0008004_abnormal_stomach_pH0.77724413
101MP0002752_abnormal_somatic_nervous0.77609775
102MP0004085_abnormal_heartbeat0.76575713
103MP0000604_amyloidosis0.75557492
104MP0008775_abnormal_heart_ventricle0.74641572
105MP0001873_stomach_inflammation0.73782223
106MP0000631_abnormal_neuroendocrine_gland0.73033615
107MP0003137_abnormal_impulse_conducting0.72423826
108MP0001929_abnormal_gametogenesis0.70481572
109MP0006036_abnormal_mitochondrial_physio0.69309466
110MP0002693_abnormal_pancreas_physiology0.68826906
111MP0005174_abnormal_tail_pigmentation0.68434475
112MP0003936_abnormal_reproductive_system0.65219483
113MP0001177_atelectasis0.64881195
114MP0003646_muscle_fatigue0.63712063
115MP0003632_abnormal_nervous_system0.63080718
116MP0000026_abnormal_inner_ear0.60504271
117MP0003634_abnormal_glial_cell0.59707502
118MP0003183_abnormal_peptide_metabolism0.58428634
119MP0003075_altered_response_to0.57833241
120MP0004510_myositis0.57654081
121MP0002653_abnormal_ependyma_morphology0.56880556
122MP0010234_abnormal_vibrissa_follicle0.56787331
123MP0001765_abnormal_ion_homeostasis0.56635163
124MP0005171_absent_coat_pigmentation0.56501829
125MP0008877_abnormal_DNA_methylation0.53776604
126MP0005084_abnormal_gallbladder_morpholo0.53744634
127MP0004043_abnormal_pH_regulation0.52846235
128MP0001943_abnormal_respiration0.50984759
129MP0006035_abnormal_mitochondrial_morpho0.48700739
130MP0000920_abnormal_myelination0.48435769
131MP0003956_abnormal_body_size0.48296232
132MP0005410_abnormal_fertilization0.48067942
133MP0010770_preweaning_lethality0.47101662
134MP0002082_postnatal_lethality0.47101662
135MP0008789_abnormal_olfactory_epithelium0.46989735

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.69587758
2Atonic seizures (HP:0010819)6.18164797
3Myokymia (HP:0002411)6.14334189
4Focal seizures (HP:0007359)5.73109248
5Epileptic encephalopathy (HP:0200134)5.72695222
6Febrile seizures (HP:0002373)5.34211070
7Hyperventilation (HP:0002883)4.97826368
8Absence seizures (HP:0002121)4.74415629
9Visual hallucinations (HP:0002367)4.71053966
10Type II lissencephaly (HP:0007260)4.53310642
11Dialeptic seizures (HP:0011146)4.32601862
12Generalized tonic-clonic seizures (HP:0002069)3.93994363
13Progressive cerebellar ataxia (HP:0002073)3.86359712
14Broad-based gait (HP:0002136)3.58692723
15Amblyopia (HP:0000646)3.55493587
16Gaze-evoked nystagmus (HP:0000640)3.38087851
17Molar tooth sign on MRI (HP:0002419)3.34893162
18Abnormality of midbrain morphology (HP:0002418)3.34893162
19Pancreatic cysts (HP:0001737)3.34530548
20Abnormality of alanine metabolism (HP:0010916)3.24969760
21Hyperalaninemia (HP:0003348)3.24969760
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.24969760
23Poor eye contact (HP:0000817)3.08503438
24Congenital stationary night blindness (HP:0007642)3.08452081
25Pancreatic fibrosis (HP:0100732)3.06834703
26Impaired vibration sensation in the lower limbs (HP:0002166)3.04331230
27True hermaphroditism (HP:0010459)2.96588236
28Epileptiform EEG discharges (HP:0011182)2.87357503
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87082679
30Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87082679
31Truncal ataxia (HP:0002078)2.86761642
32Anterior segment dysgenesis (HP:0007700)2.86597918
33Acute necrotizing encephalopathy (HP:0006965)2.85507482
34Gait imbalance (HP:0002141)2.84641789
35Anxiety (HP:0000739)2.82211677
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.81672333
37Nephronophthisis (HP:0000090)2.80629833
38Cerebellar dysplasia (HP:0007033)2.75973010
39Dysmetria (HP:0001310)2.74589966
40Dysdiadochokinesis (HP:0002075)2.74086144
41Neuroendocrine neoplasm (HP:0100634)2.72654158
42Pheochromocytoma (HP:0002666)2.71846116
43Abnormal eating behavior (HP:0100738)2.71798323
44Impaired social interactions (HP:0000735)2.71211874
45Abnormal social behavior (HP:0012433)2.71211874
46Action tremor (HP:0002345)2.71020111
47Abnormal mitochondria in muscle tissue (HP:0008316)2.69248990
48Depression (HP:0000716)2.68650262
49Congenital primary aphakia (HP:0007707)2.65982511
50Medial flaring of the eyebrow (HP:0010747)2.62092863
51Progressive macrocephaly (HP:0004481)2.60670979
52Birth length less than 3rd percentile (HP:0003561)2.60334721
53Drooling (HP:0002307)2.55105126
54Excessive salivation (HP:0003781)2.55105126
55Pendular nystagmus (HP:0012043)2.53638771
56Supranuclear gaze palsy (HP:0000605)2.52954624
57Impaired smooth pursuit (HP:0007772)2.52067763
58EEG with generalized epileptiform discharges (HP:0011198)2.51874353
59Retinal dysplasia (HP:0007973)2.50331019
60Inability to walk (HP:0002540)2.49041461
61Termporal pattern (HP:0011008)2.49005000
62Insidious onset (HP:0003587)2.49005000
63Scanning speech (HP:0002168)2.47720789
64Nephrogenic diabetes insipidus (HP:0009806)2.47267023
65Urinary bladder sphincter dysfunction (HP:0002839)2.46519422
66Congenital, generalized hypertrichosis (HP:0004540)2.45786943
67Keratoconus (HP:0000563)2.44795088
68Increased corneal curvature (HP:0100692)2.44795088
69Delusions (HP:0000746)2.42963774
70Abnormality of the renal cortex (HP:0011035)2.40536478
71Abolished electroretinogram (ERG) (HP:0000550)2.35771212
72Abnormality of the renal medulla (HP:0100957)2.34751907
73Abnormal hair whorl (HP:0010721)2.34023746
74Protruding tongue (HP:0010808)2.33652278
75Abnormality of binocular vision (HP:0011514)2.33517210
76Diplopia (HP:0000651)2.33517210
77Lissencephaly (HP:0001339)2.33430443
78Abnormal respiratory motile cilium physiology (HP:0012261)2.31780414
79Absent speech (HP:0001344)2.31775102
80Hypsarrhythmia (HP:0002521)2.31726820
81Cerebral hypomyelination (HP:0006808)2.29972260
82Dysmetric saccades (HP:0000641)2.29925102
83Cerebral inclusion bodies (HP:0100314)2.28992191
84Large for gestational age (HP:0001520)2.28665410
85Focal dystonia (HP:0004373)2.25189807
86Torticollis (HP:0000473)2.23702192
87Mitochondrial inheritance (HP:0001427)2.20920395
88Impaired vibratory sensation (HP:0002495)2.20542107
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.19719769
90Absent/shortened dynein arms (HP:0200106)2.19719769
91Abnormality of the lower motor neuron (HP:0002366)2.19194582
92Optic disc pallor (HP:0000543)2.19139431
93Acute encephalopathy (HP:0006846)2.17790041
94Genetic anticipation (HP:0003743)2.16251516
95Sclerocornea (HP:0000647)2.15956241
96Bradykinesia (HP:0002067)2.15715864
97Resting tremor (HP:0002322)2.15501825
98Stereotypic behavior (HP:0000733)2.15048868
99Attenuation of retinal blood vessels (HP:0007843)2.14203355
100Progressive inability to walk (HP:0002505)2.13502358
1013-Methylglutaconic aciduria (HP:0003535)2.13240473
102Limb dystonia (HP:0002451)2.12391271
103Status epilepticus (HP:0002133)2.11579110
104Specific learning disability (HP:0001328)2.10911476
105Abnormal rod and cone electroretinograms (HP:0008323)2.10684662
106Urinary urgency (HP:0000012)2.10512767
107Generalized myoclonic seizures (HP:0002123)2.09779911
108Ankle clonus (HP:0011448)2.09480293
109Hemiparesis (HP:0001269)2.08887103
110Autoimmune thrombocytopenia (HP:0001973)2.08477454
111Hypomagnesemia (HP:0002917)2.07753095
112Postural instability (HP:0002172)2.06755097
113Tubular atrophy (HP:0000092)2.06597442
114Sensory axonal neuropathy (HP:0003390)2.06346484
115Abnormality of ocular smooth pursuit (HP:0000617)2.06136142
116Severe muscular hypotonia (HP:0006829)2.06010457
117Hypokalemic alkalosis (HP:0001949)2.01770499
118Polyphagia (HP:0002591)2.00119094
119Aplasia/hypoplasia of the uterus (HP:0008684)1.99998308
120Craniofacial dystonia (HP:0012179)1.98528309
121Spastic gait (HP:0002064)1.98473344
122Decreased circulating renin level (HP:0003351)1.98409811
123Abnormal ciliary motility (HP:0012262)1.98212095
124Cystic liver disease (HP:0006706)1.97236911
125Pachygyria (HP:0001302)1.96933813
126Increased serum lactate (HP:0002151)1.96561691
127Incomplete penetrance (HP:0003829)1.96138401
128Vaginal atresia (HP:0000148)1.95781117
129Blue irides (HP:0000635)1.94962658
130Genital tract atresia (HP:0001827)1.94262111
131Abnormality of the labia minora (HP:0012880)1.93272657
132Poor coordination (HP:0002370)1.93203917
133Methylmalonic acidemia (HP:0002912)1.92988712
134Increased CSF lactate (HP:0002490)1.91334927
135Fetal akinesia sequence (HP:0001989)1.90765395
136Lactic acidosis (HP:0003128)1.90407839
137Progressive microcephaly (HP:0000253)1.90232160
138Hepatocellular necrosis (HP:0001404)1.88508320
139Prominent supraorbital ridges (HP:0000336)1.88416883
140Abnormality of the pons (HP:0007361)1.88215077
141Rhinitis (HP:0012384)1.87697874
142Hydroureter (HP:0000072)1.86552718
143Polydipsia (HP:0001959)1.85992898
144Abnormal drinking behavior (HP:0030082)1.85992898
145Furrowed tongue (HP:0000221)1.84647881
146Gait ataxia (HP:0002066)1.84410097
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.84282541
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.84282541
149Hypoplasia of the uterus (HP:0000013)1.83255618
150Abnormality of the corticospinal tract (HP:0002492)1.82898221
151Abnormality of magnesium homeostasis (HP:0004921)1.82283086
152Hypoplasia of the pons (HP:0012110)1.81762432
153Abnormality of salivation (HP:0100755)1.80052189
154Abnormal gallbladder physiology (HP:0012438)1.78826093
155Hepatic necrosis (HP:0002605)1.77549342
156Cerebral edema (HP:0002181)1.76967910
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76821513
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.75158391
159Horizontal nystagmus (HP:0000666)1.74738936
160Methylmalonic aciduria (HP:0012120)1.72343918
161Respiratory failure (HP:0002878)1.72033785
162Aplasia/Hypoplasia of the tibia (HP:0005772)1.71733399
163Chronic hepatic failure (HP:0100626)1.71506978
164Polyuria (HP:0000103)1.71466852
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71460706
166Leukodystrophy (HP:0002415)1.71168585
167CNS hypomyelination (HP:0003429)1.69403197
168Myotonia (HP:0002486)1.66449390
169Thyroid-stimulating hormone excess (HP:0002925)1.65459327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.86696908
2NTRK34.05889715
3CASK3.85445753
4TLK13.63120463
5FRK3.55405231
6MAP3K43.28740333
7MAP3K123.28187027
8DAPK23.20031093
9MAP2K73.19796698
10RIPK43.10164302
11PIK3CA3.09494612
12MAP3K93.07435286
13CDK192.64314940
14DAPK12.56628748
15PLK22.40169527
16ADRBK22.38789918
17TIE12.09656788
18MAP2K42.07642466
19ARAF2.03712357
20MAP4K22.03486668
21MINK12.01878561
22GRK11.94604430
23INSRR1.90927403
24STK391.80950017
25ZAK1.80312796
26BMPR21.73619426
27CCNB11.67182077
28GRK51.66352973
29BMPR1B1.66192886
30WNK41.65887347
31PNCK1.60246383
32WNK31.58194414
33LIMK11.57798387
34OXSR11.51899041
35KSR21.45461131
36PAK61.42547848
37KSR11.40940147
38PTK2B1.37809235
39PRPF4B1.37575595
40AKT31.36403556
41MARK11.34098434
42PRKCG1.29840714
43CDK51.28057921
44NME11.25170098
45CAMK2B1.25131900
46MAP3K131.24339471
47NTRK21.22309583
48NUAK11.16090420
49PRKD31.15265685
50CAMK2A1.13631430
51CAMKK11.13571210
52CAMKK21.09739193
53TNIK1.09521923
54TRIM281.08637211
55MAPK131.04657785
56PLK30.98514875
57MAP2K60.97007479
58CSNK1G30.93572471
59CSNK1G10.93157251
60BRAF0.92380348
61NTRK10.90822137
62FES0.90238674
63BUB10.89048068
64MST40.88922928
65RAF10.84384713
66STK380.84089278
67CAMK1G0.82660392
68SGK2230.82376172
69SGK4940.82376172
70VRK10.81849041
71ACVR1B0.81060111
72DAPK30.80309061
73STK38L0.78848107
74MAP3K20.78595061
75PDK30.76924216
76PDK40.76924216
77CSNK1A1L0.75432457
78CDK180.74993136
79SIK20.74724563
80CAMK2D0.73371130
81CAMK1D0.73065913
82STK160.73025320
83FGR0.71527178
84SGK20.71334959
85TSSK60.71160981
86CDK140.70195503
87PRKCI0.70066580
88CDK150.69666990
89CAMK10.68046653
90CAMK2G0.66889618
91UHMK10.65388550
92TAF10.63343313
93STK110.61013514
94CDK11A0.59587510
95VRK20.58529256
96PRKCE0.58498400
97EIF2AK30.58465631
98SIK30.58155458
99SGK10.57608510
100PDK10.57386655
101PDPK10.56669754
102DYRK1A0.56100065
103CSNK1G20.56045283
104TYRO30.54533514
105PAK30.54315771
106GRK60.52765043
107MKNK20.52040728
108DYRK20.50588569
109FER0.50121659
110MET0.48990351
111PHKG10.48258396
112PHKG20.48258396
113MAP3K60.47411308
114BCR0.46992969
115PLK10.45577158
116WEE10.44711487
117MYLK0.44229162
118CSNK1A10.43475796
119ERBB30.43398631
120MAPKAPK30.42413896
121TNK20.41816935
122SGK30.41405811
123TXK0.40913164
124PRKCA0.40487135
125PRKCH0.39408530
126MAP2K10.38767495
127IRAK10.38561362
128ADRBK10.38536872
129BCKDK0.37970483
130MAP3K10.37895694
131LATS10.37530350
132RET0.36912257
133PRKCZ0.36392370
134ROCK20.36155919
135PINK10.35858941
136FLT30.35628270
137TAOK30.35590039
138MAPK120.35435443
139MARK20.35368385
140PDK20.33820122
141GRK70.33320943
142CSNK1D0.33242778
143MAP3K70.32294730
144NEK10.31727715
145MAPK70.31713869
146PRKG10.31285872
147PRKACA0.31058003
148MOS0.30788191
149TAOK10.30742482
150RPS6KA30.30050113
151CAMK40.29182115
152TGFBR10.29055858

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.85602889
2Nicotine addiction_Homo sapiens_hsa050333.80046499
3Synaptic vesicle cycle_Homo sapiens_hsa047213.74434632
4Collecting duct acid secretion_Homo sapiens_hsa049662.95731006
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80928696
6Long-term potentiation_Homo sapiens_hsa047202.73551467
7Circadian entrainment_Homo sapiens_hsa047132.68937132
8Amphetamine addiction_Homo sapiens_hsa050312.54238496
9Morphine addiction_Homo sapiens_hsa050322.53144676
10Caffeine metabolism_Homo sapiens_hsa002322.51002217
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45629231
12GABAergic synapse_Homo sapiens_hsa047272.44955242
13Glutamatergic synapse_Homo sapiens_hsa047242.44169152
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27368905
15Protein export_Homo sapiens_hsa030602.24572155
16RNA polymerase_Homo sapiens_hsa030202.20970319
17Salivary secretion_Homo sapiens_hsa049702.18808490
18Dopaminergic synapse_Homo sapiens_hsa047282.13128144
19Nitrogen metabolism_Homo sapiens_hsa009101.99321229
20Oxidative phosphorylation_Homo sapiens_hsa001901.96411690
21Taste transduction_Homo sapiens_hsa047421.95885182
22Insulin secretion_Homo sapiens_hsa049111.95867415
23Vibrio cholerae infection_Homo sapiens_hsa051101.93385134
24Gastric acid secretion_Homo sapiens_hsa049711.82176544
25Linoleic acid metabolism_Homo sapiens_hsa005911.77043208
26Basal transcription factors_Homo sapiens_hsa030221.76420859
27Renin secretion_Homo sapiens_hsa049241.74581015
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74165666
29Vitamin B6 metabolism_Homo sapiens_hsa007501.70840926
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69493247
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67945723
32Butanoate metabolism_Homo sapiens_hsa006501.65446753
33Calcium signaling pathway_Homo sapiens_hsa040201.64136778
34Cholinergic synapse_Homo sapiens_hsa047251.63307882
35Serotonergic synapse_Homo sapiens_hsa047261.60222418
36Oxytocin signaling pathway_Homo sapiens_hsa049211.58750952
37Long-term depression_Homo sapiens_hsa047301.53525259
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.53298368
39Homologous recombination_Homo sapiens_hsa034401.52804091
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47428854
41Alzheimers disease_Homo sapiens_hsa050101.44818919
42Proteasome_Homo sapiens_hsa030501.41485566
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40989718
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40168650
45Parkinsons disease_Homo sapiens_hsa050121.35724181
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35697334
47Selenocompound metabolism_Homo sapiens_hsa004501.35109965
48GnRH signaling pathway_Homo sapiens_hsa049121.29292763
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28786939
50Cocaine addiction_Homo sapiens_hsa050301.27575464
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26389122
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24843249
53Cardiac muscle contraction_Homo sapiens_hsa042601.24593735
54cAMP signaling pathway_Homo sapiens_hsa040241.22158627
55Ether lipid metabolism_Homo sapiens_hsa005651.21219091
56Gap junction_Homo sapiens_hsa045401.16395860
57Phototransduction_Homo sapiens_hsa047441.16000524
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11485547
59Tryptophan metabolism_Homo sapiens_hsa003801.09678022
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07919941
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07537853
62Pyrimidine metabolism_Homo sapiens_hsa002401.05687681
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04958959
64Fanconi anemia pathway_Homo sapiens_hsa034601.04070434
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03816373
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03498080
67cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02210802
68Regulation of autophagy_Homo sapiens_hsa041401.00374366
69Estrogen signaling pathway_Homo sapiens_hsa049150.99263286
70One carbon pool by folate_Homo sapiens_hsa006700.98806501
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97366230
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96160907
73Propanoate metabolism_Homo sapiens_hsa006400.95525507
74Purine metabolism_Homo sapiens_hsa002300.95305076
75Huntingtons disease_Homo sapiens_hsa050160.94216019
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92626253
77Folate biosynthesis_Homo sapiens_hsa007900.92589302
78Melanogenesis_Homo sapiens_hsa049160.88927725
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88681626
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.88137601
81Glioma_Homo sapiens_hsa052140.87171393
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84037657
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82132065
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81445235
85Nucleotide excision repair_Homo sapiens_hsa034200.80153506
86Oocyte meiosis_Homo sapiens_hsa041140.78091100
87Axon guidance_Homo sapiens_hsa043600.77825872
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77568080
89Type II diabetes mellitus_Homo sapiens_hsa049300.76553533
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76500381
91ErbB signaling pathway_Homo sapiens_hsa040120.76056270
92Rheumatoid arthritis_Homo sapiens_hsa053230.76006460
93beta-Alanine metabolism_Homo sapiens_hsa004100.75533546
94Pancreatic secretion_Homo sapiens_hsa049720.75490971
95Ribosome_Homo sapiens_hsa030100.72323047
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.68558016
97Metabolic pathways_Homo sapiens_hsa011000.66730324
98Peroxisome_Homo sapiens_hsa041460.65484628
99Thyroid hormone synthesis_Homo sapiens_hsa049180.65111308
100Sulfur relay system_Homo sapiens_hsa041220.64737537
101Histidine metabolism_Homo sapiens_hsa003400.62622894
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.62394948
103Glucagon signaling pathway_Homo sapiens_hsa049220.60965216
104RNA degradation_Homo sapiens_hsa030180.60442428
105RNA transport_Homo sapiens_hsa030130.58522739
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.58504344
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54977324
108Chemical carcinogenesis_Homo sapiens_hsa052040.54831942
109MAPK signaling pathway_Homo sapiens_hsa040100.54521025
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54298003
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53557205
112Dilated cardiomyopathy_Homo sapiens_hsa054140.51559375
113Sulfur metabolism_Homo sapiens_hsa009200.51151781
114Pyruvate metabolism_Homo sapiens_hsa006200.49780298
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49471835
116VEGF signaling pathway_Homo sapiens_hsa043700.48172759
117Dorso-ventral axis formation_Homo sapiens_hsa043200.47853403
118Ras signaling pathway_Homo sapiens_hsa040140.46901018
119Non-homologous end-joining_Homo sapiens_hsa034500.46484610
120Glycerolipid metabolism_Homo sapiens_hsa005610.45711103
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44543578
122Mineral absorption_Homo sapiens_hsa049780.44105969
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44067108
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44008137
125Inositol phosphate metabolism_Homo sapiens_hsa005620.43962926
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.42139135
127Fat digestion and absorption_Homo sapiens_hsa049750.41698374
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41677923
129Arginine and proline metabolism_Homo sapiens_hsa003300.41322383
130Circadian rhythm_Homo sapiens_hsa047100.41013680
131African trypanosomiasis_Homo sapiens_hsa051430.40981448
132Fatty acid elongation_Homo sapiens_hsa000620.40691061
133Alcoholism_Homo sapiens_hsa050340.39951239
134Rap1 signaling pathway_Homo sapiens_hsa040150.39944702
135Mismatch repair_Homo sapiens_hsa034300.39181460
136Choline metabolism in cancer_Homo sapiens_hsa052310.39027050
137Phagosome_Homo sapiens_hsa041450.38110022
138Type I diabetes mellitus_Homo sapiens_hsa049400.35737985
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.35402658
140Ovarian steroidogenesis_Homo sapiens_hsa049130.30486606
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.29782590
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27329704
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26766883
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24384418
145Wnt signaling pathway_Homo sapiens_hsa043100.24330470
146Bile secretion_Homo sapiens_hsa049760.22588246
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22444485
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21930241
1492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21491232
150Insulin signaling pathway_Homo sapiens_hsa049100.20753125
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20529450
152Prion diseases_Homo sapiens_hsa050200.19355217
153Endocytosis_Homo sapiens_hsa041440.16407276
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16243196
155mTOR signaling pathway_Homo sapiens_hsa041500.15220539
156Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14758172

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