EPM2AIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The EPM2A gene, which encodes laforin, is mutated in an autosomal recessive form of adolescent progressive myoclonus epilepsy. The protein encoded by this gene binds to laforin, but its function is not known. This gene is intronless. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31440055
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14086140
3synaptic vesicle maturation (GO:0016188)5.04246446
4locomotory exploration behavior (GO:0035641)4.92624557
5synaptic vesicle exocytosis (GO:0016079)4.68046277
6pyrimidine nucleobase catabolic process (GO:0006208)4.61674967
7layer formation in cerebral cortex (GO:0021819)4.58158965
8neuron cell-cell adhesion (GO:0007158)4.55473626
9vocalization behavior (GO:0071625)4.53846997
10regulation of synaptic vesicle exocytosis (GO:2000300)4.42779840
11glutamate secretion (GO:0014047)4.42182537
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41332230
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27973256
14exploration behavior (GO:0035640)4.05106157
15regulation of glutamate receptor signaling pathway (GO:1900449)4.04821300
16neurotransmitter secretion (GO:0007269)3.95552194
17protein localization to synapse (GO:0035418)3.95415968
18dendritic spine morphogenesis (GO:0060997)3.92793738
19nucleobase catabolic process (GO:0046113)3.85446894
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.80589494
21neuron recognition (GO:0008038)3.80017210
22regulation of synaptic vesicle transport (GO:1902803)3.78448953
23neuronal action potential propagation (GO:0019227)3.68967040
24proline transport (GO:0015824)3.63745034
25dendrite morphogenesis (GO:0048813)3.61809761
26gamma-aminobutyric acid transport (GO:0015812)3.60636561
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.58298132
28activation of protein kinase A activity (GO:0034199)3.55876702
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53001899
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52434143
31regulation of neuronal synaptic plasticity (GO:0048168)3.51786313
32glutamate receptor signaling pathway (GO:0007215)3.51580517
33axonal fasciculation (GO:0007413)3.49889807
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43804250
35neural tube formation (GO:0001841)3.43533277
36cellular potassium ion homeostasis (GO:0030007)3.39325883
37regulation of synapse structural plasticity (GO:0051823)3.37636555
38synaptic transmission, glutamatergic (GO:0035249)3.37403995
39response to pheromone (GO:0019236)3.37289911
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35268352
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.34699461
42transmission of nerve impulse (GO:0019226)3.34028485
43neuron-neuron synaptic transmission (GO:0007270)3.33460443
44neurotransmitter transport (GO:0006836)3.31301363
45cerebellar Purkinje cell differentiation (GO:0021702)3.28459103
46long-term memory (GO:0007616)3.20008614
47neurotransmitter-gated ion channel clustering (GO:0072578)3.19016930
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17044478
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16878356
50positive regulation of mitochondrial fission (GO:0090141)3.15788661
51mating behavior (GO:0007617)3.14974411
52vesicle transport along microtubule (GO:0047496)3.14706396
53mechanosensory behavior (GO:0007638)3.11417758
54gamma-aminobutyric acid signaling pathway (GO:0007214)3.06891984
55sodium ion export (GO:0071436)3.06024947
56positive regulation of synapse maturation (GO:0090129)3.04873314
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04626604
58postsynaptic membrane organization (GO:0001941)3.03885526
59innervation (GO:0060384)3.02973112
60auditory behavior (GO:0031223)3.02517515
61regulation of neurotransmitter levels (GO:0001505)3.02328548
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02094111
63cerebral cortex radially oriented cell migration (GO:0021799)3.01879638
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00025555
65presynaptic membrane assembly (GO:0097105)2.99821277
66neuromuscular process controlling balance (GO:0050885)2.98698049
67organelle transport along microtubule (GO:0072384)2.97858218
68synapse assembly (GO:0007416)2.97535146
69positive regulation of membrane potential (GO:0045838)2.96009155
70regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95757982
71regulation of postsynaptic membrane potential (GO:0060078)2.95333967
72behavioral response to nicotine (GO:0035095)2.94276830
73cell communication by electrical coupling (GO:0010644)2.94190497
74protein prenylation (GO:0018342)2.93801692
75prenylation (GO:0097354)2.93801692
76cell migration in hindbrain (GO:0021535)2.93620499
77regulation of dendritic spine morphogenesis (GO:0061001)2.93573049
78limb bud formation (GO:0060174)2.92060995
79epithelial cilium movement (GO:0003351)2.90532209
80synaptic vesicle endocytosis (GO:0048488)2.88556927
81synapse organization (GO:0050808)2.88140870
82negative regulation of oligodendrocyte differentiation (GO:0048715)2.87641857
83neuronal action potential (GO:0019228)2.86341901
84retinal ganglion cell axon guidance (GO:0031290)2.85784181
85regulation of neurotransmitter secretion (GO:0046928)2.85486313
86regulation of vesicle fusion (GO:0031338)2.85365338
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.85115915
88negative regulation of astrocyte differentiation (GO:0048712)2.83497607
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81856912
90neuron fate determination (GO:0048664)2.80926761
91presynaptic membrane organization (GO:0097090)2.80419124
92calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.79485268
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.78544889
94neuromuscular process controlling posture (GO:0050884)2.78541310
95cerebellar granule cell differentiation (GO:0021707)2.78391976
96protein K11-linked deubiquitination (GO:0035871)2.77912066
97prepulse inhibition (GO:0060134)2.77721869
98membrane depolarization during action potential (GO:0086010)2.77353758
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76978582
100response to auditory stimulus (GO:0010996)2.76479925
101glycine transport (GO:0015816)2.75571903
102long-term synaptic potentiation (GO:0060291)2.75276471
103cerebellar Purkinje cell layer development (GO:0021680)2.75054276
104regulation of synaptic plasticity (GO:0048167)2.74768119
105central nervous system projection neuron axonogenesis (GO:0021952)2.74598364
106establishment of nucleus localization (GO:0040023)2.74364103
107membrane hyperpolarization (GO:0060081)2.73845995
108inositol phosphate catabolic process (GO:0071545)2.73301866
109startle response (GO:0001964)2.72541522
110neuronal ion channel clustering (GO:0045161)2.72288849
111positive regulation of potassium ion transmembrane transport (GO:1901381)2.71708455
112central nervous system myelination (GO:0022010)2.70509928
113axon ensheathment in central nervous system (GO:0032291)2.70509928
114detection of calcium ion (GO:0005513)2.69723720
115protein polyglutamylation (GO:0018095)2.69236602
116olfactory bulb development (GO:0021772)2.68341830
117positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67800346
118intraciliary transport (GO:0042073)2.66750489
119membrane depolarization (GO:0051899)2.65992577
120protein targeting to Golgi (GO:0000042)2.65992346
121suckling behavior (GO:0001967)2.64912497
122central nervous system neuron axonogenesis (GO:0021955)2.64104811
123regulation of calcium ion-dependent exocytosis (GO:0017158)2.63921038
124intraspecies interaction between organisms (GO:0051703)2.63357848
125social behavior (GO:0035176)2.63357848
126regulation of neurotransmitter transport (GO:0051588)2.63265159
127appendage development (GO:0048736)2.63086665
128limb development (GO:0060173)2.63086665
129regulation of ARF protein signal transduction (GO:0032012)2.62424957
130regulation of synaptic transmission, GABAergic (GO:0032228)2.61945609
131axon cargo transport (GO:0008088)2.60956597
132nonmotile primary cilium assembly (GO:0035058)2.58430413
133protein localization to cilium (GO:0061512)2.53174572
134dentate gyrus development (GO:0021542)2.51485758
135cytoplasmic mRNA processing body assembly (GO:0033962)2.51429672
136righting reflex (GO:0060013)2.51178719
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48753189
138negative regulation of neurotransmitter transport (GO:0051589)2.47287531
139reflex (GO:0060004)2.47204548
140regulation of oligodendrocyte differentiation (GO:0048713)2.44949463
141positive regulation of mRNA processing (GO:0050685)2.44252575
142cilium assembly (GO:0042384)2.42215456
143establishment of protein localization to Golgi (GO:0072600)2.41614567
144cilium organization (GO:0044782)2.41436540
145C4-dicarboxylate transport (GO:0015740)2.41219677
146regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.38872657
147axoneme assembly (GO:0035082)2.38447872
148behavioral defense response (GO:0002209)2.36849283
149behavioral fear response (GO:0001662)2.36849283
150somite development (GO:0061053)2.36559890
151hindbrain development (GO:0030902)2.36209386
152negative regulation of dendrite development (GO:2000171)2.36202022
153neuromuscular synaptic transmission (GO:0007274)2.34286772
154negative regulation of neurotransmitter secretion (GO:0046929)2.34071848
155histone H3-K4 trimethylation (GO:0080182)2.33196573
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.33032653
157pancreas development (GO:0031016)2.32660405
158kidney morphogenesis (GO:0060993)2.32628717
159establishment of mitochondrion localization (GO:0051654)2.32285516
160nerve growth factor signaling pathway (GO:0038180)2.32067748
161cilium morphogenesis (GO:0060271)2.29785677
162regulation of feeding behavior (GO:0060259)2.29755862
163spinal cord motor neuron differentiation (GO:0021522)2.28582194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.16848478
2GBX2_23144817_ChIP-Seq_PC3_Human3.28531772
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.90716660
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88643288
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82353232
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56904230
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56904230
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47432976
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45556877
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.44252001
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41375689
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41081529
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.40942067
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37662462
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37577260
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37131287
17REST_21632747_ChIP-Seq_MESCs_Mouse2.33724616
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31767090
19DROSHA_22980978_ChIP-Seq_HELA_Human2.25357552
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22244259
21VDR_22108803_ChIP-Seq_LS180_Human2.22081137
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.20452916
23EWS_26573619_Chip-Seq_HEK293_Human2.13516403
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.09843202
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07618049
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.06401083
27AR_21572438_ChIP-Seq_LNCaP_Human2.04920073
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.03070694
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92219454
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90184903
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88939770
32TAF15_26573619_Chip-Seq_HEK293_Human1.87909859
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.87790948
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81767474
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76863350
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71317680
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70255606
38ZNF274_21170338_ChIP-Seq_K562_Hela1.68772860
39SMAD4_21799915_ChIP-Seq_A2780_Human1.65536232
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.60238265
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58511347
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55516541
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45739502
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44324823
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43628612
46IGF1R_20145208_ChIP-Seq_DFB_Human1.43134323
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.42894087
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42661276
49P300_19829295_ChIP-Seq_ESCs_Human1.42486208
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.42190030
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.41849003
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41620617
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.41609312
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41320549
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40538632
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40217324
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38873327
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38261770
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.37921487
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37769512
61CBP_20019798_ChIP-Seq_JUKART_Human1.37769512
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37140821
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35709401
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32491514
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32172770
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31534512
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.31438439
68STAT3_23295773_ChIP-Seq_U87_Human1.31367627
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30724172
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28928792
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28684228
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28364685
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.28218447
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25791145
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25267717
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.24679445
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24225541
78AR_19668381_ChIP-Seq_PC3_Human1.23641909
79AR_25329375_ChIP-Seq_VCAP_Human1.23087696
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22591651
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22193441
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22104066
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.21965349
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21584601
85AHR_22903824_ChIP-Seq_MCF-7_Human1.21148384
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20942623
87P53_22387025_ChIP-Seq_ESCs_Mouse1.20613758
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.20575679
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.16885455
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16669259
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.15240998
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14500604
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14182766
94FUS_26573619_Chip-Seq_HEK293_Human1.13242695
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13238269
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12514179
97TCF4_22108803_ChIP-Seq_LS180_Human1.12268171
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.11609380
99* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10291342
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10214009
101* TCF4_23295773_ChIP-Seq_U87_Human1.09677114
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.09499408
103RNF2_27304074_Chip-Seq_NSC_Mouse1.09222840
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.08257261
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08181629
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.08097344
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07674889
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07443859
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07388881
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07320487
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05867376
112SOX9_26525672_Chip-Seq_HEART_Mouse1.05016332
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04699582
114JUN_21703547_ChIP-Seq_K562_Human1.04286413
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03873828
116RUNX2_22187159_ChIP-Seq_PCA_Human1.03156839
117HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02148795
118BCAT_22108803_ChIP-Seq_LS180_Human1.01611766
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.01492023
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01363188
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01332298
122ER_23166858_ChIP-Seq_MCF-7_Human1.00503870
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99354803
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98361399
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.98172212
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97851052
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95927835
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.95596420
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.94825319
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94710398
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93809491
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93809491
133KDM2B_26808549_Chip-Seq_K562_Human0.93407553
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91845404
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90883195
136TP53_16413492_ChIP-PET_HCT116_Human0.90868130
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90775906
138TP53_18474530_ChIP-ChIP_U2OS_Human0.90684125
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.89712729
140ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88287124
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87261458

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08120677
2MP0003880_abnormal_central_pattern4.36839385
3MP0003635_abnormal_synaptic_transmissio3.64159336
4MP0004270_analgesia3.50734379
5MP0005423_abnormal_somatic_nervous2.98253111
6MP0008877_abnormal_DNA_methylation2.88863394
7MP0009745_abnormal_behavioral_response2.88381787
8MP0002063_abnormal_learning/memory/cond2.84512872
9MP0009046_muscle_twitch2.79673623
10MP0002064_seizures2.74967407
11MP0009780_abnormal_chondrocyte_physiolo2.48562957
12MP0002734_abnormal_mechanical_nocicepti2.47944034
13MP0002572_abnormal_emotion/affect_behav2.46570753
14MP0001968_abnormal_touch/_nociception2.42966254
15MP0001486_abnormal_startle_reflex2.42072645
16MP0002272_abnormal_nervous_system2.34187791
17MP0003122_maternal_imprinting2.19737026
18MP0006276_abnormal_autonomic_nervous2.05992178
19MP0000778_abnormal_nervous_system2.03828965
20MP0002184_abnormal_innervation1.96899137
21MP0002909_abnormal_adrenal_gland1.94375016
22MP0002733_abnormal_thermal_nociception1.91527498
23MP0002735_abnormal_chemical_nociception1.88249032
24MP0002067_abnormal_sensory_capabilities1.87932050
25MP0001440_abnormal_grooming_behavior1.86854483
26MP0001501_abnormal_sleep_pattern1.85499481
27MP0008569_lethality_at_weaning1.78573437
28MP0005386_behavior/neurological_phenoty1.76092623
29MP0004924_abnormal_behavior1.76092623
30MP0005645_abnormal_hypothalamus_physiol1.76042113
31MP0001970_abnormal_pain_threshold1.75856936
32MP0006292_abnormal_olfactory_placode1.74450423
33MP0002736_abnormal_nociception_after1.70815743
34MP0000955_abnormal_spinal_cord1.67547727
35MP0002557_abnormal_social/conspecific_i1.67168240
36MP0003329_amyloid_beta_deposits1.61011732
37MP0004811_abnormal_neuron_physiology1.59029695
38MP0003195_calcinosis1.58793354
39MP0002822_catalepsy1.57337540
40MP0004885_abnormal_endolymph1.56118412
41MP0005646_abnormal_pituitary_gland1.54840224
42MP0002882_abnormal_neuron_morphology1.49829506
43MP0001984_abnormal_olfaction1.49585456
44MP0003890_abnormal_embryonic-extraembry1.48471813
45MP0000013_abnormal_adipose_tissue1.47763336
46MP0000566_synostosis1.47695781
47MP0002751_abnormal_autonomic_nervous1.43995686
48MP0004133_heterotaxia1.39730080
49MP0002102_abnormal_ear_morphology1.39631975
50MP0001502_abnormal_circadian_rhythm1.36759012
51MP0002066_abnormal_motor_capabilities/c1.36508465
52MP0003787_abnormal_imprinting1.36113819
53MP0004858_abnormal_nervous_system1.35898111
54MP0003283_abnormal_digestive_organ1.35750129
55MP0001529_abnormal_vocalization1.30129157
56MP0005551_abnormal_eye_electrophysiolog1.28974820
57MP0004145_abnormal_muscle_electrophysio1.26473224
58MP0005248_abnormal_Harderian_gland1.25673207
59MP0002837_dystrophic_cardiac_calcinosis1.23848044
60MP0008057_abnormal_DNA_replication1.21718974
61MP0000569_abnormal_digit_pigmentation1.20210554
62MP0003567_abnormal_fetal_cardiomyocyte1.19568319
63MP0002152_abnormal_brain_morphology1.18185001
64MP0008789_abnormal_olfactory_epithelium1.17257774
65MP0003633_abnormal_nervous_system1.15853006
66MP0008995_early_reproductive_senescence1.15480711
67MP0001905_abnormal_dopamine_level1.15055609
68MP0001299_abnormal_eye_distance/1.14023675
69MP0006072_abnormal_retinal_apoptosis1.13755603
70MP0004142_abnormal_muscle_tone1.13099305
71MP0000751_myopathy1.11155881
72MP0000631_abnormal_neuroendocrine_gland1.10875945
73MP0004742_abnormal_vestibular_system1.08415427
74MP0002938_white_spotting1.08070620
75MP0002229_neurodegeneration1.08035966
76MP0003634_abnormal_glial_cell1.07556780
77MP0002928_abnormal_bile_duct1.06385871
78MP0010386_abnormal_urinary_bladder1.00604563
79MP0003631_nervous_system_phenotype0.99176236
80MP0003879_abnormal_hair_cell0.99038606
81MP0000920_abnormal_myelination0.98629560
82MP0000516_abnormal_urinary_system0.97186024
83MP0005367_renal/urinary_system_phenotyp0.97186024
84MP0004043_abnormal_pH_regulation0.94668320
85MP0004085_abnormal_heartbeat0.94593624
86MP0003136_yellow_coat_color0.92775730
87MP0008961_abnormal_basal_metabolism0.91693885
88MP0002069_abnormal_eating/drinking_beha0.90226282
89MP0005220_abnormal_exocrine_pancreas0.90092565
90MP0001177_atelectasis0.89637344
91MP0002752_abnormal_somatic_nervous0.88241956
92MP0005187_abnormal_penis_morphology0.87752612
93MP0002638_abnormal_pupillary_reflex0.86203553
94MP0003937_abnormal_limbs/digits/tail_de0.85648071
95MP0000427_abnormal_hair_cycle0.85303766
96MP0004233_abnormal_muscle_weight0.84754490
97MP0005623_abnormal_meninges_morphology0.84738395
98MP0003121_genomic_imprinting0.84716143
99MP0003690_abnormal_glial_cell0.83601519
100MP0001944_abnormal_pancreas_morphology0.83424088
101MP0003632_abnormal_nervous_system0.82745255
102MP0003137_abnormal_impulse_conducting0.82643669
103MP0004215_abnormal_myocardial_fiber0.82085359
104MP0002090_abnormal_vision0.81166546
105MP0003938_abnormal_ear_development0.80949824
106MP0000026_abnormal_inner_ear0.80943803
107MP0001188_hyperpigmentation0.79089856
108MP0005195_abnormal_posterior_eye0.78928695
109MP0001963_abnormal_hearing_physiology0.77990525
110MP0002234_abnormal_pharynx_morphology0.77569059
111MP0005535_abnormal_body_temperature0.77517446
112MP0005499_abnormal_olfactory_system0.76666194
113MP0005394_taste/olfaction_phenotype0.76666194
114MP0000639_abnormal_adrenal_gland0.76451955
115MP0005391_vision/eye_phenotype0.76122895
116MP0010234_abnormal_vibrissa_follicle0.74100976
117MP0003119_abnormal_digestive_system0.72514015
118MP0003861_abnormal_nervous_system0.72409830
119MP0001485_abnormal_pinna_reflex0.72335898
120MP0005253_abnormal_eye_physiology0.71928457
121MP0000372_irregular_coat_pigmentation0.71187176
122MP0001943_abnormal_respiration0.69934586
123MP0000534_abnormal_ureter_morphology0.69815581
124MP0000747_muscle_weakness0.65130840
125MP0000003_abnormal_adipose_tissue0.65063523
126MP0003123_paternal_imprinting0.64437024
127MP0008872_abnormal_physiological_respon0.59713636
128MP0000537_abnormal_urethra_morphology0.59051032
129MP0010770_preweaning_lethality0.58047609

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.65350776
2Myokymia (HP:0002411)4.76327867
3Focal seizures (HP:0007359)4.73787534
4Visual hallucinations (HP:0002367)4.67430354
5Atonic seizures (HP:0010819)3.82892849
6Epileptic encephalopathy (HP:0200134)3.81781924
7Progressive cerebellar ataxia (HP:0002073)3.75659806
8Action tremor (HP:0002345)3.62324173
9Absence seizures (HP:0002121)3.56403452
10Supranuclear gaze palsy (HP:0000605)3.47700443
11Pancreatic cysts (HP:0001737)3.35742333
12Febrile seizures (HP:0002373)3.32361269
13True hermaphroditism (HP:0010459)3.29586008
14Pancreatic fibrosis (HP:0100732)3.24034850
15Generalized tonic-clonic seizures (HP:0002069)3.24022186
16Ankle clonus (HP:0011448)3.23521222
17Hypothermia (HP:0002045)3.16795203
18Dialeptic seizures (HP:0011146)3.16173810
19Papilledema (HP:0001085)3.14236296
20Nephronophthisis (HP:0000090)3.03692122
21Abnormality of midbrain morphology (HP:0002418)3.02525719
22Molar tooth sign on MRI (HP:0002419)3.02525719
23Truncal ataxia (HP:0002078)2.99106922
24Broad-based gait (HP:0002136)2.97499580
25Pheochromocytoma (HP:0002666)2.95066113
26Termporal pattern (HP:0011008)2.94893875
27Insidious onset (HP:0003587)2.94893875
28Drooling (HP:0002307)2.91564975
29Excessive salivation (HP:0003781)2.91564975
30Limb dystonia (HP:0002451)2.87214117
31Medial flaring of the eyebrow (HP:0010747)2.86786470
32Agitation (HP:0000713)2.86163145
33Depression (HP:0000716)2.84837857
34Abnormality of the corticospinal tract (HP:0002492)2.78343451
35Neurofibrillary tangles (HP:0002185)2.75506241
36Progressive inability to walk (HP:0002505)2.73121802
37Cerebral inclusion bodies (HP:0100314)2.72726506
38Chronic hepatic failure (HP:0100626)2.71892870
39Anxiety (HP:0000739)2.70468026
40Megalencephaly (HP:0001355)2.68672569
41Abnormality of the renal medulla (HP:0100957)2.67421156
42Dysdiadochokinesis (HP:0002075)2.67025707
43Impaired vibration sensation in the lower limbs (HP:0002166)2.66324791
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.66216682
45Mutism (HP:0002300)2.65719600
46Spastic gait (HP:0002064)2.63893558
47Poor eye contact (HP:0000817)2.61305859
48Urinary bladder sphincter dysfunction (HP:0002839)2.59697794
49Dysmetria (HP:0001310)2.59494524
50Urinary urgency (HP:0000012)2.55636782
51Abnormality of the labia minora (HP:0012880)2.55556675
52Genetic anticipation (HP:0003743)2.53506989
53Intestinal atresia (HP:0011100)2.52550897
54Impaired social interactions (HP:0000735)2.52037590
55Abnormal social behavior (HP:0012433)2.52037590
56Scanning speech (HP:0002168)2.51448769
57Hyperventilation (HP:0002883)2.47794677
58Hemiparesis (HP:0001269)2.46135361
59EEG with generalized epileptiform discharges (HP:0011198)2.46081269
60Neuroendocrine neoplasm (HP:0100634)2.45749362
61Macroorchidism (HP:0000053)2.45745410
62Epileptiform EEG discharges (HP:0011182)2.43927859
63Gaze-evoked nystagmus (HP:0000640)2.43541314
64Abnormality of the renal cortex (HP:0011035)2.43332904
65Postural instability (HP:0002172)2.43315406
66Congenital primary aphakia (HP:0007707)2.42546196
67Abnormal eating behavior (HP:0100738)2.41310567
68Papillary thyroid carcinoma (HP:0002895)2.37876268
69Hypsarrhythmia (HP:0002521)2.36897259
70Intention tremor (HP:0002080)2.35892346
71Volvulus (HP:0002580)2.34134062
72Renal cortical cysts (HP:0000803)2.32475938
73Nephrogenic diabetes insipidus (HP:0009806)2.30579227
74Lower limb muscle weakness (HP:0007340)2.28880074
75Protruding tongue (HP:0010808)2.25498616
76Genital tract atresia (HP:0001827)2.23520771
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.16401695
78Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16401695
79Torticollis (HP:0000473)2.14389145
80Colon cancer (HP:0003003)2.13884222
81Neoplasm of the adrenal cortex (HP:0100641)2.13735802
82Vaginal atresia (HP:0000148)2.11343343
83Absent speech (HP:0001344)2.11264791
84Amblyopia (HP:0000646)2.11161002
85Abnormality of binocular vision (HP:0011514)2.10885622
86Diplopia (HP:0000651)2.10885622
87Tented upper lip vermilion (HP:0010804)2.08736230
88Cystic liver disease (HP:0006706)2.06849748
89Postural tremor (HP:0002174)2.04321562
90Amyotrophic lateral sclerosis (HP:0007354)2.03352275
91Blue irides (HP:0000635)2.03220614
92Hemiplegia (HP:0002301)2.01333432
93Tubulointerstitial nephritis (HP:0001970)2.00477104
94Impaired smooth pursuit (HP:0007772)1.99509119
95Bile duct proliferation (HP:0001408)1.98657170
96Abnormal biliary tract physiology (HP:0012439)1.98657170
97Thyroid carcinoma (HP:0002890)1.97791207
98Bradykinesia (HP:0002067)1.97648919
99Central scotoma (HP:0000603)1.94304062
100Optic nerve hypoplasia (HP:0000609)1.93931936
101Abnormality of salivation (HP:0100755)1.93736167
102Buphthalmos (HP:0000557)1.92793769
103Hypoventilation (HP:0002791)1.92554342
104Polyphagia (HP:0002591)1.92522566
105Stereotypic behavior (HP:0000733)1.92480816
106Lissencephaly (HP:0001339)1.90564823
107Congenital stationary night blindness (HP:0007642)1.89785960
108Insomnia (HP:0100785)1.89585434
109Sclerocornea (HP:0000647)1.89227338
110Pachygyria (HP:0001302)1.88675196
111Neoplasm of the heart (HP:0100544)1.86837170
112Clonus (HP:0002169)1.86467538
113Abnormality of the lower motor neuron (HP:0002366)1.84679309
114Focal dystonia (HP:0004373)1.84466617
115Narrow forehead (HP:0000341)1.84451559
116Akinesia (HP:0002304)1.84060972
117Oligodactyly (hands) (HP:0001180)1.83670662
118Postaxial hand polydactyly (HP:0001162)1.83351244
119Exotropia (HP:0000577)1.81776801
120Neoplasm of the peripheral nervous system (HP:0100007)1.81590814
121Generalized myoclonic seizures (HP:0002123)1.81359583
122Aplasia involving bones of the extremities (HP:0009825)1.81176790
123Aplasia involving bones of the upper limbs (HP:0009823)1.81176790
124Aplasia of the phalanges of the hand (HP:0009802)1.81176790
125Thyroid-stimulating hormone excess (HP:0002925)1.80506089
126Morphological abnormality of the pyramidal tract (HP:0002062)1.80337628
127Poor coordination (HP:0002370)1.78887076
128Abnormality of ocular smooth pursuit (HP:0000617)1.78735238
129Ventricular fibrillation (HP:0001663)1.78525280
130Inability to walk (HP:0002540)1.77860088
131Fair hair (HP:0002286)1.77756187
132Psychosis (HP:0000709)1.76540589
133Neoplasm of the oral cavity (HP:0100649)1.76232030
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.74916451
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.74229245
136Anencephaly (HP:0002323)1.74158835
137Neuronal loss in central nervous system (HP:0002529)1.74113705
138Furrowed tongue (HP:0000221)1.73842892
139Gait imbalance (HP:0002141)1.73733842
140Inappropriate behavior (HP:0000719)1.71714510
141Limb hypertonia (HP:0002509)1.70586825
142Craniofacial dystonia (HP:0012179)1.70387042
143Specific learning disability (HP:0001328)1.70376602
144Resting tremor (HP:0002322)1.70319243
145Gait ataxia (HP:0002066)1.70245139
146Hepatoblastoma (HP:0002884)1.70192469
147Male pseudohermaphroditism (HP:0000037)1.69983025
148Widely spaced teeth (HP:0000687)1.69848941
149Aqueductal stenosis (HP:0002410)1.69762923
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.69660613
151Absent/shortened dynein arms (HP:0200106)1.69660613
152Tubular atrophy (HP:0000092)1.69401667
153Ankyloglossia (HP:0010296)1.69299148
154Attenuation of retinal blood vessels (HP:0007843)1.69001232
155Dyskinesia (HP:0100660)1.67295827
156Postaxial foot polydactyly (HP:0001830)1.64723141
157Bony spicule pigmentary retinopathy (HP:0007737)1.64304425
158Medulloblastoma (HP:0002885)1.63040182
159Astrocytoma (HP:0009592)1.62972592
160Abnormality of the astrocytes (HP:0100707)1.62972592
161Short foot (HP:0001773)1.62860379
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61973098
163Abnormality of the metopic suture (HP:0005556)1.60815242

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.20099499
2NTRK34.08283603
3MAP3K93.34116775
4MAP3K43.08497991
5EPHA42.58085944
6MINK12.45664930
7NTRK22.36735832
8MAP2K72.20169255
9PAK62.15302793
10NTRK12.01635980
11NUAK12.00996828
12MAP2K41.98447032
13PNCK1.97265402
14TRIM281.87740143
15MAP4K21.78090054
16KSR21.71376248
17PHKG21.69351956
18PHKG11.69351956
19MKNK21.68070433
20UHMK11.63590812
21MAPK131.61307276
22DAPK21.61183622
23AKT31.57439796
24PINK11.57105489
25CASK1.56033063
26BRD41.50395627
27CDK51.50179590
28PRKD31.49226448
29KSR11.44046384
30MAP3K21.43990354
31CAMKK11.41359705
32DYRK21.38607970
33TNIK1.36555225
34EPHA31.34770158
35PAK31.30656809
36CAMK1G1.29849056
37BMPR1B1.21453573
38MAP3K121.19935257
39SIK21.17719705
40RET1.17605319
41CSNK1G21.16681662
42WEE11.09949822
43LATS21.08051430
44PLK21.07674132
45CAMKK21.03222310
46SGK2231.01890414
47SGK4941.01890414
48MKNK11.01714513
49SCYL21.01653155
50FGFR21.01274770
51WNK11.01039120
52PRKCG1.00066477
53GRK50.99512879
54TYRO30.99004397
55DYRK30.97027992
56PRKCH0.96476693
57BRSK20.95419888
58STK390.95215575
59GRK10.94448721
60CAMK2A0.94083566
61STK380.93199673
62CDK190.93063229
63OXSR10.92821149
64STK110.91101373
65OBSCN0.90648242
66TAF10.90503736
67DYRK1A0.89913846
68WNK30.86573132
69PLK40.84882938
70CDK140.84433628
71MARK20.81730578
72PRPF4B0.81231491
73CAMK2B0.81220805
74LMTK20.81004048
75FES0.80061702
76CDK150.79833660
77NLK0.79372798
78CDK180.79098998
79STK38L0.76030799
80WNK40.74873440
81ERBB30.74734823
82ADRBK20.73911190
83EIF2AK30.71900755
84PKN10.71356010
85SGK20.70177398
86SGK10.69821380
87CSNK1G30.68778738
88MAP3K130.68758382
89CDK11A0.67958043
90CDC42BPA0.66638372
91INSRR0.66156846
92CAMK10.65175791
93CSNK1A1L0.64135775
94SGK30.62470967
95CCNB10.62254033
96PDGFRA0.61880349
97CAMK2D0.61579237
98TAOK10.59807358
99FER0.59792395
100PRKCE0.59704297
101YES10.59688492
102ACVR1B0.59192907
103TAOK30.58585058
104ALK0.56962144
105PRKAA10.55142626
106PRKCZ0.54023455
107RPS6KA30.53384274
108MAPK100.53157150
109FYN0.53060250
110RIPK10.52789549
111BCR0.52444503
112MAP3K70.51239786
113RIPK40.50101861
114FRK0.49967908
115HIPK20.48997358
116DAPK10.48721725
117VRK10.48490244
118PIK3CA0.48435143
119ROCK20.47873082
120CSNK1G10.47522740
121DMPK0.47445687
122DDR20.47075960
123MAP3K10.46129328
124MAPKAPK50.45363937
125PDPK10.44432588
126RPS6KA20.44330694
127PDK10.44296050
128PRKACA0.43205063
129DYRK1B0.43121178
130PASK0.42770860
131CAMK2G0.42733745
132PRKG10.42514073
133ARAF0.40977258
134CAMK40.39528282
135CSNK1D0.38575314
136CSNK1A10.37568158
137RPS6KA40.35842712
138PLK30.33626308
139ATM0.32202210
140CSNK1E0.30931502
141LATS10.30905017

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.25380693
2Synaptic vesicle cycle_Homo sapiens_hsa047212.83251676
3GABAergic synapse_Homo sapiens_hsa047272.71768219
4Protein export_Homo sapiens_hsa030602.65829896
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48166479
6Circadian entrainment_Homo sapiens_hsa047132.42678613
7Glutamatergic synapse_Homo sapiens_hsa047242.35415748
8Morphine addiction_Homo sapiens_hsa050322.29538177
9Olfactory transduction_Homo sapiens_hsa047402.24039863
10Long-term potentiation_Homo sapiens_hsa047202.23292248
11Amphetamine addiction_Homo sapiens_hsa050312.16026755
12Dopaminergic synapse_Homo sapiens_hsa047282.13232706
13Insulin secretion_Homo sapiens_hsa049112.11928094
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10782630
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88772089
16Cholinergic synapse_Homo sapiens_hsa047251.85208740
17Cocaine addiction_Homo sapiens_hsa050301.83740789
18Salivary secretion_Homo sapiens_hsa049701.81180184
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75690490
20Taste transduction_Homo sapiens_hsa047421.74424561
21Propanoate metabolism_Homo sapiens_hsa006401.71822162
22Gastric acid secretion_Homo sapiens_hsa049711.69078513
23Serotonergic synapse_Homo sapiens_hsa047261.68815425
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68654502
25Renin secretion_Homo sapiens_hsa049241.65440475
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62671182
27Long-term depression_Homo sapiens_hsa047301.57000414
28Oxytocin signaling pathway_Homo sapiens_hsa049211.44693764
29Type II diabetes mellitus_Homo sapiens_hsa049301.44503249
30Axon guidance_Homo sapiens_hsa043601.33517753
31GnRH signaling pathway_Homo sapiens_hsa049121.32897646
32Gap junction_Homo sapiens_hsa045401.29953876
33Calcium signaling pathway_Homo sapiens_hsa040201.27992315
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27015429
35Estrogen signaling pathway_Homo sapiens_hsa049151.21874412
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20479166
37Regulation of autophagy_Homo sapiens_hsa041401.19290632
38cAMP signaling pathway_Homo sapiens_hsa040241.15128658
39Phototransduction_Homo sapiens_hsa047441.14796572
40Steroid biosynthesis_Homo sapiens_hsa001001.13402353
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11100042
42Dorso-ventral axis formation_Homo sapiens_hsa043201.10457892
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09608212
44Basal transcription factors_Homo sapiens_hsa030221.09547847
45Collecting duct acid secretion_Homo sapiens_hsa049661.07963356
46Ether lipid metabolism_Homo sapiens_hsa005651.06624565
47Melanogenesis_Homo sapiens_hsa049161.05508430
48ErbB signaling pathway_Homo sapiens_hsa040121.04106819
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02486853
50Glioma_Homo sapiens_hsa052141.02452912
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01357607
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01340512
53RNA degradation_Homo sapiens_hsa030181.01206230
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01082293
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99275016
56Fanconi anemia pathway_Homo sapiens_hsa034600.98789221
57Nitrogen metabolism_Homo sapiens_hsa009100.98753012
58Vibrio cholerae infection_Homo sapiens_hsa051100.96792446
59Cardiac muscle contraction_Homo sapiens_hsa042600.95268143
60Linoleic acid metabolism_Homo sapiens_hsa005910.91670567
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91667812
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.91120708
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90525515
64Thyroid hormone synthesis_Homo sapiens_hsa049180.89030213
65Dilated cardiomyopathy_Homo sapiens_hsa054140.88698456
66Pancreatic secretion_Homo sapiens_hsa049720.88695195
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85049815
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82968416
69Oxidative phosphorylation_Homo sapiens_hsa001900.78309490
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.77616476
71Renal cell carcinoma_Homo sapiens_hsa052110.76806077
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75157120
73Peroxisome_Homo sapiens_hsa041460.71768673
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70104053
75Glucagon signaling pathway_Homo sapiens_hsa049220.70080714
76MAPK signaling pathway_Homo sapiens_hsa040100.70051441
77Oocyte meiosis_Homo sapiens_hsa041140.70011577
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69426708
79Choline metabolism in cancer_Homo sapiens_hsa052310.67813562
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66542310
81Endometrial cancer_Homo sapiens_hsa052130.65447750
82mTOR signaling pathway_Homo sapiens_hsa041500.63947745
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63682292
84Butanoate metabolism_Homo sapiens_hsa006500.63241602
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62817128
86Parkinsons disease_Homo sapiens_hsa050120.61624581
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61250113
88Selenocompound metabolism_Homo sapiens_hsa004500.60269183
89ABC transporters_Homo sapiens_hsa020100.60122295
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59879054
91Alcoholism_Homo sapiens_hsa050340.59842314
92Wnt signaling pathway_Homo sapiens_hsa043100.59732240
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59277676
94TGF-beta signaling pathway_Homo sapiens_hsa043500.57285051
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57099533
96Insulin signaling pathway_Homo sapiens_hsa049100.56888595
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.56495696
98Ras signaling pathway_Homo sapiens_hsa040140.56179162
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56023147
100Bile secretion_Homo sapiens_hsa049760.54933169
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53608059
102Tryptophan metabolism_Homo sapiens_hsa003800.52114521
103Prion diseases_Homo sapiens_hsa050200.52057259
104Hedgehog signaling pathway_Homo sapiens_hsa043400.51282998
105Circadian rhythm_Homo sapiens_hsa047100.50927656
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50857810
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50425197
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50273687
109Lysine degradation_Homo sapiens_hsa003100.49753909
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49694964
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.48850765
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.48741509
113Type I diabetes mellitus_Homo sapiens_hsa049400.48599062
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48230992
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47306480
116Ovarian steroidogenesis_Homo sapiens_hsa049130.47090002
117VEGF signaling pathway_Homo sapiens_hsa043700.46963319
118mRNA surveillance pathway_Homo sapiens_hsa030150.46598827
119Inositol phosphate metabolism_Homo sapiens_hsa005620.46186933
120Endocytosis_Homo sapiens_hsa041440.46075145
121Rap1 signaling pathway_Homo sapiens_hsa040150.45171670
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43582950
123beta-Alanine metabolism_Homo sapiens_hsa004100.43087181
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.42791943
125Non-homologous end-joining_Homo sapiens_hsa034500.42185445
126Colorectal cancer_Homo sapiens_hsa052100.41005446
127Non-small cell lung cancer_Homo sapiens_hsa052230.39792183
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39067168
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36656727
130Fatty acid metabolism_Homo sapiens_hsa012120.36064465
131AMPK signaling pathway_Homo sapiens_hsa041520.32982311
132Prolactin signaling pathway_Homo sapiens_hsa049170.32334852
133Tight junction_Homo sapiens_hsa045300.32266533
134Alzheimers disease_Homo sapiens_hsa050100.30882425

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