EPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.48021856
2sodium ion export (GO:0071436)4.40788533
3locomotory exploration behavior (GO:0035641)4.29739462
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.88357950
5semaphorin-plexin signaling pathway (GO:0071526)3.72061667
6cell-cell junction maintenance (GO:0045217)3.72028353
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54887158
8lysine catabolic process (GO:0006554)3.54718568
9lysine metabolic process (GO:0006553)3.54718568
10layer formation in cerebral cortex (GO:0021819)3.53842189
11activation of Rac GTPase activity (GO:0032863)3.51111924
12cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.47093256
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39247585
14regulation of cholesterol homeostasis (GO:2000188)3.37943054
15glutamate secretion (GO:0014047)3.37837105
16mannose metabolic process (GO:0006013)3.37574403
17adherens junction assembly (GO:0034333)3.37387801
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.35692358
19negative regulation of fatty acid transport (GO:2000192)3.34618104
20vocalization behavior (GO:0071625)3.32525383
21dicarboxylic acid biosynthetic process (GO:0043650)3.30587541
22regulation of glucose import in response to insulin stimulus (GO:2001273)3.29178746
23focal adhesion assembly (GO:0048041)3.27340437
24cell-substrate adherens junction assembly (GO:0007045)3.27340437
25cytoskeletal anchoring at plasma membrane (GO:0007016)3.26924477
26planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26060446
27regulation of ARF protein signal transduction (GO:0032012)3.24590170
28cell communication by electrical coupling (GO:0010644)3.24127191
29regulation of synapse structural plasticity (GO:0051823)3.17144029
30alpha-linolenic acid metabolic process (GO:0036109)3.13612232
31activation of protein kinase A activity (GO:0034199)3.13139130
32positive regulation of CREB transcription factor activity (GO:0032793)3.12447384
33apoptotic process involved in morphogenesis (GO:0060561)3.09870351
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08968233
35negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.08131551
36endothelial cell chemotaxis (GO:0035767)3.06682902
37cellular potassium ion homeostasis (GO:0030007)3.00807637
38positive regulation of fibroblast migration (GO:0010763)2.99693825
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98553048
40adhesion of symbiont to host (GO:0044406)2.96162621
41regulation of glutamate receptor signaling pathway (GO:1900449)2.95789427
42negative regulation of catenin import into nucleus (GO:0035414)2.94690065
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92272947
44cell-substrate junction assembly (GO:0007044)2.88538444
45regulation of ARF GTPase activity (GO:0032312)2.87001016
46cell junction maintenance (GO:0034331)2.86533009
47peptidyl-tyrosine autophosphorylation (GO:0038083)2.86413887
48regulation of neuronal synaptic plasticity (GO:0048168)2.85627353
49negative regulation of cell size (GO:0045792)2.84813452
50adhesion of symbiont to host cell (GO:0044650)2.83735624
51virion attachment to host cell (GO:0019062)2.83735624
52glutamate metabolic process (GO:0006536)2.83373904
53desmosome organization (GO:0002934)2.82704324
54synaptic vesicle exocytosis (GO:0016079)2.82546236
55aspartate family amino acid catabolic process (GO:0009068)2.82050375
56positive regulation of fatty acid oxidation (GO:0046321)2.81565507
57atrioventricular valve morphogenesis (GO:0003181)2.80979697
58neurotransmitter secretion (GO:0007269)2.80746147
59regulation of synaptic vesicle exocytosis (GO:2000300)2.80687469
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80608593
61exploration behavior (GO:0035640)2.79285677
62regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77852656
63regulation of synapse maturation (GO:0090128)2.77749720
64cell communication involved in cardiac conduction (GO:0086065)2.77681001
65regulation of fatty acid beta-oxidation (GO:0031998)2.76173963
66cell migration in hindbrain (GO:0021535)2.75941304
67dendritic spine morphogenesis (GO:0060997)2.73012728
68dopamine receptor signaling pathway (GO:0007212)2.72179182
69proline transport (GO:0015824)2.72055336
70epithelial cell-cell adhesion (GO:0090136)2.71794144
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71299117
72regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70436738
73alanine transport (GO:0032328)2.69748791
74regulation of long-term neuronal synaptic plasticity (GO:0048169)2.65821506
75striated muscle atrophy (GO:0014891)2.64822221
76positive regulation of protein dephosphorylation (GO:0035307)2.64417970
77basement membrane organization (GO:0071711)2.63612015
782-oxoglutarate metabolic process (GO:0006103)2.63519558
79glycine transport (GO:0015816)2.63197043
80negative regulation of cholesterol transport (GO:0032375)2.63069823
81negative regulation of sterol transport (GO:0032372)2.63069823
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.60579435
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59396048
84L-phenylalanine metabolic process (GO:0006558)2.59396048
85neuromuscular process controlling balance (GO:0050885)2.57358480
86regulation of synaptic vesicle transport (GO:1902803)2.57001672
87L-phenylalanine catabolic process (GO:0006559)2.56768159
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56768159
89gamma-aminobutyric acid transport (GO:0015812)2.56236299
90cellular response to pH (GO:0071467)2.54950189
91protein retention in ER lumen (GO:0006621)2.54547255
92hemidesmosome assembly (GO:0031581)2.53785159
93potassium ion import (GO:0010107)2.53346776
94vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52555313
95regulation of clathrin-mediated endocytosis (GO:2000369)2.52470984
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51219898
97neurotransmitter-gated ion channel clustering (GO:0072578)2.51194024
98positive regulation of histone deacetylation (GO:0031065)2.51169722
99cellular sodium ion homeostasis (GO:0006883)2.50012707
100cerebellar Purkinje cell layer development (GO:0021680)2.49646623
101cellular modified amino acid catabolic process (GO:0042219)2.46966795
102positive regulation of synapse maturation (GO:0090129)2.46893634
103positive regulation of fatty acid beta-oxidation (GO:0032000)2.46796692
104urea metabolic process (GO:0019627)2.45216579
105urea cycle (GO:0000050)2.45216579
106skeletal muscle adaptation (GO:0043501)2.44862512
107kynurenine metabolic process (GO:0070189)2.43777974
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43011222
109plasma membrane repair (GO:0001778)2.42434800
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.41847633
111insulin-like growth factor receptor signaling pathway (GO:0048009)2.41610587
112regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40551619
113actin filament depolymerization (GO:0030042)2.39972765
114actin filament bundle organization (GO:0061572)2.39898192
115actin filament bundle assembly (GO:0051017)2.39898192
116positive regulation of protein deacetylation (GO:0090312)2.39545667
117intracellular estrogen receptor signaling pathway (GO:0030520)2.39010304
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38458762
119myelin maintenance (GO:0043217)2.38405771
120negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38019825
121neural tube development (GO:0021915)2.37764962
122phosphate ion transmembrane transport (GO:0035435)2.37312115
123protein localization to endosome (GO:0036010)2.36786880
124cysteine metabolic process (GO:0006534)2.36125610
125activation of MAPKKK activity (GO:0000185)2.35878668
126regulation of extracellular matrix disassembly (GO:0010715)2.35750818
127stress fiber assembly (GO:0043149)2.35515998
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.35464998
129GDP-mannose metabolic process (GO:0019673)2.35359498
130carnitine shuttle (GO:0006853)2.34112404
131positive regulation of lipid catabolic process (GO:0050996)2.33231386
132phosphate ion transport (GO:0006817)2.32969055
133dicarboxylic acid catabolic process (GO:0043649)2.31961471
134regulation of hydrogen peroxide metabolic process (GO:0010310)2.30954885
135glyoxylate metabolic process (GO:0046487)2.30824910
136regulation of histone deacetylation (GO:0031063)2.30815669
137sulfur amino acid catabolic process (GO:0000098)2.29908086
138fatty acid transmembrane transport (GO:1902001)2.29646999
139regulation of cholesterol biosynthetic process (GO:0045540)2.28632827
140positive regulation of triglyceride biosynthetic process (GO:0010867)2.28510481
141regulation of fatty acid oxidation (GO:0046320)2.28503153
142regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.27239239
143cellular ketone body metabolic process (GO:0046950)2.27054466
144drug catabolic process (GO:0042737)2.26341630
145negative regulation of potassium ion transmembrane transport (GO:1901380)2.26204007
146apoptotic process involved in development (GO:1902742)2.26196269
147establishment of apical/basal cell polarity (GO:0035089)2.26188768
148negative regulation of myotube differentiation (GO:0010832)2.26022398
149barbed-end actin filament capping (GO:0051016)2.26020073
150protein targeting to plasma membrane (GO:0072661)2.25091266
151cerebellar granule cell differentiation (GO:0021707)2.24640785
152proline biosynthetic process (GO:0006561)2.24443532
153negative regulation of viral release from host cell (GO:1902187)2.24124946
154glucose 6-phosphate metabolic process (GO:0051156)2.24080000
155osteoblast development (GO:0002076)2.23735317
156regulation of dendritic spine morphogenesis (GO:0061001)2.22805447
157negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.21668653
158protein heterotrimerization (GO:0070208)2.20863641
159tooth mineralization (GO:0034505)2.20561683
160skeletal muscle organ development (GO:0060538)2.19916021
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.19807554
162establishment of nucleus localization (GO:0040023)2.19788635
163regulation of early endosome to late endosome transport (GO:2000641)2.19508776
164negative regulation of lipid transport (GO:0032369)2.19169647
165positive regulation of receptor recycling (GO:0001921)2.19120074
166receptor catabolic process (GO:0032801)2.18697420
167positive regulation of triglyceride metabolic process (GO:0090208)2.17638335
168nitrogen cycle metabolic process (GO:0071941)2.17325490
169high-density lipoprotein particle remodeling (GO:0034375)2.17302536
170regulation of triglyceride catabolic process (GO:0010896)2.16190220
171negative regulation of erythrocyte differentiation (GO:0045647)2.15353888
172signal complex assembly (GO:0007172)2.13702646
173convergent extension (GO:0060026)2.13676478
174interleukin-1-mediated signaling pathway (GO:0070498)2.13655171
175synaptic vesicle endocytosis (GO:0048488)2.13570154
176platelet formation (GO:0030220)2.12847539
177membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.12801555
178long-term memory (GO:0007616)2.12262670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.62648998
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94696286
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.75702405
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.72562132
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.69335014
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.50300840
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.45694905
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38947584
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36750046
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.34333374
11* LXR_22292898_ChIP-Seq_THP-1_Human2.34003939
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.27441094
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.18936192
14KDM2B_26808549_Chip-Seq_K562_Human2.13904718
15* KDM2B_26808549_Chip-Seq_DND41_Human2.11280014
16DROSHA_22980978_ChIP-Seq_HELA_Human2.02948395
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01696987
18EZH2_22144423_ChIP-Seq_EOC_Human1.97335308
19* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94657738
20* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89823425
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.89078735
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88022521
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.87016053
24* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86606186
25ZNF263_19887448_ChIP-Seq_K562_Human1.81421596
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75139661
27GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73138377
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.72187493
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69341456
30TCF7_22412390_ChIP-Seq_EML_Mouse1.66884339
31MYC_22102868_ChIP-Seq_BL_Human1.65133488
32GATA1_19941826_ChIP-Seq_K562_Human1.63318445
33* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61487473
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58880585
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56791313
36SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55488863
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.55180096
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53925318
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53237886
40RACK7_27058665_Chip-Seq_MCF-7_Human1.52878589
41CREB1_26743006_Chip-Seq_LNCaP_Human1.51569734
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48818246
43SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45916747
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.45881429
45TP53_22127205_ChIP-Seq_IMR90_Human1.44208744
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.41581518
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40477679
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40477679
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.40437766
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39106948
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38847142
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38533439
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.38390709
54CTCF_27219007_Chip-Seq_Bcells_Human1.35623131
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35417051
56REST_21632747_ChIP-Seq_MESCs_Mouse1.33923620
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32555706
58BCL6_27268052_Chip-Seq_Bcells_Human1.32284444
59P68_20966046_ChIP-Seq_HELA_Human1.31816227
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29256189
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28519978
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27484744
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26849847
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.25222781
65* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24760635
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24624020
67SMC4_20622854_ChIP-Seq_HELA_Human1.24594478
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23573763
69SA1_27219007_Chip-Seq_Bcells_Human1.22662684
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22429329
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22349965
72PHF8_20622854_ChIP-Seq_HELA_Human1.21738936
73* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.20314812
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20290054
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.20192743
76E2F1_20622854_ChIP-Seq_HELA_Human1.19926986
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19512236
78FOXA2_19822575_ChIP-Seq_HepG2_Human1.18697671
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16429229
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15644400
81* VDR_24763502_ChIP-Seq_THP-1_Human1.15399271
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14199727
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13446530
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13309383
85CTCF_20526341_ChIP-Seq_ESCs_Human1.13144438
86JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12669456
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12428475
88RARA_24833708_ChIP-Seq_LIVER_Mouse1.12300375
89* OCT4_19829295_ChIP-Seq_ESCs_Human1.11293101
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11262114
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10993755
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10077933
93RARB_24833708_ChIP-Seq_LIVER_Mouse1.09709803
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09363668
95VDR_21846776_ChIP-Seq_THP-1_Human1.09201109
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.09038002
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.08534851
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.08477080
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08210755
100* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08207038
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07889357
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07718441
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.06794179
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.06290477
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05612076
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05217862
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04926683
108* GATA2_19941826_ChIP-Seq_K562_Human1.04019093
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.03981887
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03952495
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03434457
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03093208
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02894094
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02836907
115P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02396595
116* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02069616
117TBX20_22080862_ChIP-Seq_HEART_Mouse1.01384198
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.01384198
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00435127
120BCOR_27268052_Chip-Seq_Bcells_Human0.99544834
121TP63_22573176_ChIP-Seq_HFKS_Human0.98854627
122CLOCK_20551151_ChIP-Seq_293T_Human0.98633461
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98470951
124TET1_21490601_ChIP-Seq_MESCs_Mouse0.96977847
125ESR1_20079471_ChIP-ChIP_T-47D_Human0.96785916
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96067985
127ATF3_27146783_Chip-Seq_COLON_Human0.95093054
128RUNX1_27514584_Chip-Seq_MCF-7_Human0.94593019
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93667681
130RING1B_27294783_Chip-Seq_ESCs_Mouse0.92127004
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91754571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.43346709
2MP0005360_urolithiasis3.87925611
3MP0002139_abnormal_hepatobiliary_system3.37839169
4MP0003705_abnormal_hypodermis_morpholog3.04922602
5MP0005085_abnormal_gallbladder_physiolo2.76335501
6MP0005409_darkened_coat_color2.66613719
7MP0002822_catalepsy2.55603911
8MP0002249_abnormal_larynx_morphology2.50048017
9MP0003635_abnormal_synaptic_transmissio2.49690785
10MP0009840_abnormal_foam_cell2.38606428
11MP0008961_abnormal_basal_metabolism2.38515426
12MP0005451_abnormal_body_composition2.38045198
13MP0005365_abnormal_bile_salt2.37820318
14MP0000678_abnormal_parathyroid_gland2.32713814
15MP0003329_amyloid_beta_deposits2.21720309
16MP0005083_abnormal_biliary_tract2.18149112
17MP0005670_abnormal_white_adipose2.17543000
18MP0009780_abnormal_chondrocyte_physiolo2.12614663
19MP0002909_abnormal_adrenal_gland2.07237935
20MP0010329_abnormal_lipoprotein_level2.06761535
21MP0004270_analgesia2.05621952
22MP0004130_abnormal_muscle_cell2.05204912
23MP0000566_synostosis2.02789593
24MP0004858_abnormal_nervous_system2.00492874
25MP0002837_dystrophic_cardiac_calcinosis1.99831956
26MP0001348_abnormal_lacrimal_gland1.98138376
27MP0002063_abnormal_learning/memory/cond1.95965091
28MP0010234_abnormal_vibrissa_follicle1.93990783
29MP0005058_abnormal_lysosome_morphology1.93491463
30MP0003252_abnormal_bile_duct1.89750258
31MP0008875_abnormal_xenobiotic_pharmacok1.88593970
32MP0003191_abnormal_cellular_cholesterol1.88119875
33MP0000751_myopathy1.85678187
34MP0003300_gastrointestinal_ulcer1.81564544
35MP0001958_emphysema1.74055695
36MP0003656_abnormal_erythrocyte_physiolo1.72683863
37MP0008438_abnormal_cutaneous_collagen1.70944919
38MP0002064_seizures1.70097986
39MP0009745_abnormal_behavioral_response1.67052845
40MP0003075_altered_response_to1.65384402
41MP0003283_abnormal_digestive_organ1.56802676
42MP0005257_abnormal_intraocular_pressure1.56202332
43MP0000604_amyloidosis1.51109182
44MP0004885_abnormal_endolymph1.51066274
45MP0001664_abnormal_digestion1.49689301
46MP0003566_abnormal_cell_adhesion1.48884278
47MP0000537_abnormal_urethra_morphology1.47853424
48MP0003879_abnormal_hair_cell1.46225803
49MP0003279_aneurysm1.44400469
50MP0005167_abnormal_blood-brain_barrier1.43383251
51MP0003303_peritoneal_inflammation1.39953038
52MP0001666_abnormal_nutrient_absorption1.38364402
53MP0008569_lethality_at_weaning1.36525154
54MP0002118_abnormal_lipid_homeostasis1.30794848
55MP0004510_myositis1.30181917
56MP0000534_abnormal_ureter_morphology1.29639870
57MP0009379_abnormal_foot_pigmentation1.29051418
58MP0005332_abnormal_amino_acid1.26900631
59MP0000747_muscle_weakness1.26076535
60MP0001440_abnormal_grooming_behavior1.25118928
61MP0003453_abnormal_keratinocyte_physiol1.23618722
62MP0004811_abnormal_neuron_physiology1.20275711
63MP0003646_muscle_fatigue1.20202129
64MP0002572_abnormal_emotion/affect_behav1.19982538
65MP0004185_abnormal_adipocyte_glucose1.19580155
66MP0002796_impaired_skin_barrier1.18988792
67MP0010030_abnormal_orbit_morphology1.18929101
68MP0004087_abnormal_muscle_fiber1.17298972
69MP0003091_abnormal_cell_migration1.14548838
70MP0008874_decreased_physiological_sensi1.13881153
71MP0006138_congestive_heart_failure1.13494858
72MP0000538_abnormal_urinary_bladder1.12690320
73MP0003633_abnormal_nervous_system1.10938920
74MP0009278_abnormal_bone_marrow1.10442965
75MP0005666_abnormal_adipose_tissue1.09558408
76MP0001502_abnormal_circadian_rhythm1.09222167
77MP0000609_abnormal_liver_physiology1.09146032
78MP0009046_muscle_twitch1.08595250
79MP0005330_cardiomyopathy1.08477083
80MP0000733_abnormal_muscle_development1.07555171
81MP0009384_cardiac_valve_regurgitation1.07114784
82MP0003172_abnormal_lysosome_physiology1.06713915
83MP0002269_muscular_atrophy1.06010072
84MP0000467_abnormal_esophagus_morphology1.04451634
85MP0009053_abnormal_anal_canal1.04448345
86MP0005584_abnormal_enzyme/coenzyme_acti1.03257502
87MP0000750_abnormal_muscle_regeneration1.03190770
88MP0008872_abnormal_physiological_respon1.02486740
89MP0003123_paternal_imprinting1.02064021
90MP0005535_abnormal_body_temperature1.01634657
91MP0005375_adipose_tissue_phenotype1.01262955
92MP0003690_abnormal_glial_cell1.01160494
93MP0005166_decreased_susceptibility_to0.99999354
94MP0001968_abnormal_touch/_nociception0.98994824
95MP0002896_abnormal_bone_mineralization0.98232114
96MP0004043_abnormal_pH_regulation0.98221946
97MP0002733_abnormal_thermal_nociception0.96567229
98MP0004272_abnormal_basement_membrane0.96325641
99MP0001873_stomach_inflammation0.96262437
100MP0004084_abnormal_cardiac_muscle0.95914101
101MP0004215_abnormal_myocardial_fiber0.95464478
102MP0000003_abnormal_adipose_tissue0.95256890
103MP0003880_abnormal_central_pattern0.95105901
104MP0005423_abnormal_somatic_nervous0.95075321
105MP0004264_abnormal_extraembryonic_tissu0.93683827
106MP0000767_abnormal_smooth_muscle0.91068145
107MP0004233_abnormal_muscle_weight0.90940554
108MP0002734_abnormal_mechanical_nocicepti0.90287220
109MP0004036_abnormal_muscle_relaxation0.89901521
110MP0005501_abnormal_skin_physiology0.89572407
111MP0003183_abnormal_peptide_metabolism0.89438176
112MP0005319_abnormal_enzyme/_coenzyme0.89153209
113MP0001501_abnormal_sleep_pattern0.88108368
114MP0003137_abnormal_impulse_conducting0.87530578
115MP0002078_abnormal_glucose_homeostasis0.86659677
116MP0001765_abnormal_ion_homeostasis0.86645503
117MP0001486_abnormal_startle_reflex0.86034665
118MP0002877_abnormal_melanocyte_morpholog0.86026815
119MP0004085_abnormal_heartbeat0.85943636
120MP0000462_abnormal_digestive_system0.85750372
121MP0002272_abnormal_nervous_system0.84873303
122MP0003634_abnormal_glial_cell0.83949383
123MP0003045_fibrosis0.82586622
124MP0005448_abnormal_energy_balance0.82558218
125MP0004145_abnormal_muscle_electrophysio0.82258642
126MP0002089_abnormal_postnatal_growth/wei0.81959071
127MP0005023_abnormal_wound_healing0.81904011
128MP0000955_abnormal_spinal_cord0.80666310
129MP0004484_altered_response_of0.80665910
130MP0000681_abnormal_thyroid_gland0.79863000
131MP0005076_abnormal_cell_differentiation0.78529551
132MP0002098_abnormal_vibrissa_morphology0.77753962
133MP0003631_nervous_system_phenotype0.77289437
134MP0001970_abnormal_pain_threshold0.76957191
135MP0000749_muscle_degeneration0.76708312
136MP0002932_abnormal_joint_morphology0.76442749
137MP0005381_digestive/alimentary_phenotyp0.76322464
138MP0005503_abnormal_tendon_morphology0.75842260
139MP0002066_abnormal_motor_capabilities/c0.75670374
140MP0005595_abnormal_vascular_smooth0.75277905
141MP0001849_ear_inflammation0.73959521
142MP0005620_abnormal_muscle_contractility0.73561897
143MP0003195_calcinosis0.73465828
144MP0002254_reproductive_system_inflammat0.73221793
145MP0005508_abnormal_skeleton_morphology0.72755124
146MP0000579_abnormal_nail_morphology0.72603360
147MP0010630_abnormal_cardiac_muscle0.72404688
148MP0003942_abnormal_urinary_system0.71212282
149MP0005386_behavior/neurological_phenoty0.70758423
150MP0004924_abnormal_behavior0.70758423
151MP0000470_abnormal_stomach_morphology0.70722635
152MP0002069_abnormal_eating/drinking_beha0.70659530
153MP0002971_abnormal_brown_adipose0.70285727
154MP0000759_abnormal_skeletal_muscle0.69901244
155MP0000013_abnormal_adipose_tissue0.69799642
156MP0005623_abnormal_meninges_morphology0.69371872
157MP0004019_abnormal_vitamin_homeostasis0.68993056
158MP0002998_abnormal_bone_remodeling0.67604601
159MP0002653_abnormal_ependyma_morphology0.66511608
160MP0001663_abnormal_digestive_system0.66371344
161MP0002060_abnormal_skin_morphology0.65845585

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.99404222
2Myokymia (HP:0002411)3.85721845
3Abnormality of the lower motor neuron (HP:0002366)3.40963938
4Reticulocytosis (HP:0001923)3.37757354
5Deep venous thrombosis (HP:0002625)3.37418423
6Protrusio acetabuli (HP:0003179)3.28098328
7Shallow orbits (HP:0000586)3.22457714
8Ulnar bowing (HP:0003031)3.11617261
9Distal lower limb amyotrophy (HP:0008944)3.09294962
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.08114966
11Bronchomalacia (HP:0002780)3.03742779
12Polycythemia (HP:0001901)3.00940227
13Visual hallucinations (HP:0002367)2.99413973
14Broad face (HP:0000283)2.97425709
15Bundle branch block (HP:0011710)2.96149425
16Stridor (HP:0010307)2.86717136
17Hemorrhage of the eye (HP:0011885)2.84327166
18Mildly elevated creatine phosphokinase (HP:0008180)2.83788539
19Increased connective tissue (HP:0009025)2.83294905
20Abnormality of the Achilles tendon (HP:0005109)2.82704827
21Ventricular fibrillation (HP:0001663)2.82449244
22Xanthomatosis (HP:0000991)2.81816255
23Thin bony cortex (HP:0002753)2.81592103
24Insomnia (HP:0100785)2.78641122
25Acanthocytosis (HP:0001927)2.77865928
26Dysmetric saccades (HP:0000641)2.70572173
27Myopathic facies (HP:0002058)2.67296874
28Premature rupture of membranes (HP:0001788)2.66849679
29Achilles tendon contracture (HP:0001771)2.66557823
30Sudden death (HP:0001699)2.63776084
31Poikilocytosis (HP:0004447)2.61752322
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.60153899
33Broad metatarsal (HP:0001783)2.59610732
34Exercise-induced myalgia (HP:0003738)2.59530931
35Supranuclear gaze palsy (HP:0000605)2.56847149
36Focal seizures (HP:0007359)2.54007328
37Postural instability (HP:0002172)2.53071968
38Gout (HP:0001997)2.50781419
39Abnormal social behavior (HP:0012433)2.48789606
40Impaired social interactions (HP:0000735)2.48789606
41Distal lower limb muscle weakness (HP:0009053)2.47427030
42Fragile skin (HP:0001030)2.47175972
43Hyperacusis (HP:0010780)2.44249992
44Ketosis (HP:0001946)2.43951911
45Increased cerebral lipofuscin (HP:0011813)2.43349929
46Cholelithiasis (HP:0001081)2.41115741
47Depression (HP:0000716)2.41100107
48Distal upper limb amyotrophy (HP:0007149)2.37142387
49Upper limb amyotrophy (HP:0009129)2.37142387
50Disproportionate tall stature (HP:0001519)2.35242834
51Cerebral inclusion bodies (HP:0100314)2.33124261
52Type 1 muscle fiber predominance (HP:0003803)2.31735964
53Ketoacidosis (HP:0001993)2.31242447
54Bladder diverticulum (HP:0000015)2.29156928
55Focal motor seizures (HP:0011153)2.28247348
56Complement deficiency (HP:0004431)2.28115277
57Myoglobinuria (HP:0002913)2.26447962
58Breast hypoplasia (HP:0003187)2.25744582
59Rectal prolapse (HP:0002035)2.25002160
60Action tremor (HP:0002345)2.24852985
61Lymphangioma (HP:0100764)2.23233877
62Spinal rigidity (HP:0003306)2.22449496
63Status epilepticus (HP:0002133)2.22070044
64Global brain atrophy (HP:0002283)2.18609578
65Poor eye contact (HP:0000817)2.18316470
66Resting tremor (HP:0002322)2.17723147
67Hemiplegia (HP:0002301)2.17306991
68Impaired vibration sensation in the lower limbs (HP:0002166)2.16034900
69Cholecystitis (HP:0001082)2.13711185
70Abnormal gallbladder physiology (HP:0012438)2.13711185
71Abnormal gallbladder morphology (HP:0012437)2.13603498
72Exercise-induced muscle cramps (HP:0003710)2.13523960
73Torticollis (HP:0000473)2.12747943
74Bowing of the arm (HP:0006488)2.11033173
75Bowed forearm bones (HP:0003956)2.11033173
76Difficulty running (HP:0009046)2.10550513
77Hypoventilation (HP:0002791)2.09403754
78Asymmetric septal hypertrophy (HP:0001670)2.07169068
79Hydroxyprolinuria (HP:0003080)2.07058842
80Abnormality of proline metabolism (HP:0010907)2.07058842
81Urinary urgency (HP:0000012)2.05998694
82Increased variability in muscle fiber diameter (HP:0003557)2.05592073
83Ankle clonus (HP:0011448)2.04787515
84Heart block (HP:0012722)2.04471089
85Genu recurvatum (HP:0002816)2.04267458
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03959775
87Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02889173
88Hand muscle atrophy (HP:0009130)2.02062566
89Cervical subluxation (HP:0003308)2.01936008
90Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01038943
91Neonatal onset (HP:0003623)2.00528714
92Hyperparathyroidism (HP:0000843)2.00422158
93Cerebral aneurysm (HP:0004944)2.00333979
94Easy fatigability (HP:0003388)2.00238259
95Bulbar palsy (HP:0001283)2.00236357
96Papilledema (HP:0001085)1.99306789
97Atrioventricular block (HP:0001678)1.99214415
98Hyperammonemia (HP:0001987)1.98858982
99Intrahepatic cholestasis (HP:0001406)1.98348931
100Mitral regurgitation (HP:0001653)1.98248584
101Abnormal atrioventricular conduction (HP:0005150)1.97545438
102Rapidly progressive (HP:0003678)1.96226529
103Onion bulb formation (HP:0003383)1.95443898
104Hyperlipoproteinemia (HP:0010980)1.95155260
105Turricephaly (HP:0000262)1.94914051
106Malnutrition (HP:0004395)1.94639918
107Lower limb amyotrophy (HP:0007210)1.94006197
108Focal dystonia (HP:0004373)1.94000314
109Urinary bladder sphincter dysfunction (HP:0002839)1.92300007
110Flat acetabular roof (HP:0003180)1.91252812
111Right ventricular cardiomyopathy (HP:0011663)1.91173584
112Hyporeflexia of lower limbs (HP:0002600)1.90460630
113Generalized tonic-clonic seizures (HP:0002069)1.89650340
114Annular pancreas (HP:0001734)1.89053831
115Elfin facies (HP:0004428)1.88397677
116Hypoalphalipoproteinemia (HP:0003233)1.87943670
117Ventricular arrhythmia (HP:0004308)1.87339677
118Blue sclerae (HP:0000592)1.86423868
119Round ear (HP:0100830)1.85717031
120Thin ribs (HP:0000883)1.85583893
121Centrally nucleated skeletal muscle fibers (HP:0003687)1.84644536
122Renovascular hypertension (HP:0100817)1.84066300
123Aneurysm (HP:0002617)1.84030662
124Hypercortisolism (HP:0001578)1.83639748
125Hyperbilirubinemia (HP:0002904)1.83369533
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.83076596
127Intention tremor (HP:0002080)1.82755825
128Craniofacial dystonia (HP:0012179)1.82566827
129Pointed chin (HP:0000307)1.82536250
130Coxa vara (HP:0002812)1.82528686
131Sensorimotor neuropathy (HP:0007141)1.81602232
132Dysdiadochokinesis (HP:0002075)1.81449434
133Long palpebral fissure (HP:0000637)1.81113179
134Hamartoma of the eye (HP:0010568)1.80115296
135Syncope (HP:0001279)1.79577469
136Vertebral compression fractures (HP:0002953)1.77143074
137Difficulty climbing stairs (HP:0003551)1.77033981
138Neurofibrillary tangles (HP:0002185)1.76455199
139Epidermoid cyst (HP:0200040)1.75837475
140Clumsiness (HP:0002312)1.75489551
141Abnormality of the aortic arch (HP:0012303)1.75315212
142Renal duplication (HP:0000075)1.75281093
143Macroorchidism (HP:0000053)1.75094137
144Anxiety (HP:0000739)1.75082862
145Abnormality of binocular vision (HP:0011514)1.74937797
146Diplopia (HP:0000651)1.74937797
147Aplasia of the phalanges of the hand (HP:0009802)1.74584187
148Aplasia involving bones of the extremities (HP:0009825)1.74584187
149Aplasia involving bones of the upper limbs (HP:0009823)1.74584187
150Insidious onset (HP:0003587)1.73455956
151Termporal pattern (HP:0011008)1.73455956
152J-shaped sella turcica (HP:0002680)1.73297866
153Polygenic inheritance (HP:0010982)1.73166073
154Abnormality of complement system (HP:0005339)1.72763529
155Late onset (HP:0003584)1.72662362
156Segmental peripheral demyelination/remyelination (HP:0003481)1.72630248
157Atrophic scars (HP:0001075)1.71828012
158Generalized amyotrophy (HP:0003700)1.70212938
159Ileus (HP:0002595)1.69146852
160Hyperglycinuria (HP:0003108)1.68590251
161Axonal loss (HP:0003447)1.68517925
162Abnormality of skeletal muscle fiber size (HP:0012084)1.67417299
163Coronal craniosynostosis (HP:0004440)1.67265375
164Overriding aorta (HP:0002623)1.66783419
165Abdominal distention (HP:0003270)1.66461047
166Flat cornea (HP:0007720)1.65937201
167Skin nodule (HP:0200036)1.65418668
168Ankle contracture (HP:0006466)1.64658658
169Back pain (HP:0003418)1.64313337
170Premature skin wrinkling (HP:0100678)1.60917542
171Joint stiffness (HP:0001387)1.58777947
172Hyperextensible skin (HP:0000974)1.58748578
173Abnormality of the fingertips (HP:0001211)1.58718181
174Broad distal phalanx of finger (HP:0009836)1.58642616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.10574570
2MAP3K93.02603820
3PKN23.02056092
4EPHA22.89403111
5PRKD32.52298727
6DAPK22.48223220
7IRAK32.43571209
8SMG12.41281109
9EPHA42.34943863
10KSR22.33600899
11RIPK12.09628904
12MAP3K102.08378525
13PAK62.06816269
14TAOK12.04098305
15ERN12.03390357
16CAMKK11.99527808
17MST1R1.92293152
18NTRK31.85257407
19ICK1.81642671
20SIK21.69948190
21EEF2K1.52248391
22LMTK21.52140659
23CDK121.47851437
24MINK11.47635324
25ALK1.42612827
26TYRO31.40488571
27STK381.38377471
28MAP3K41.35376847
29NEK11.35158215
30MARK11.32833337
31NTRK11.31707615
32MAP3K71.30909648
33SIK11.30403497
34MAP2K41.30334016
35PTK61.29958808
36BMX1.29360768
37TTN1.28218424
38PRKG21.25322366
39PRKCH1.23722312
40RET1.21117804
41PHKG21.20139079
42PHKG11.20139079
43MAP3K21.16402582
44PDGFRA1.14622548
45EPHB21.09794213
46MET1.09136209
47PAK41.06624342
48KSR11.06454769
49EPHB11.04181179
50ARAF1.03392139
51DMPK1.01232670
52NTRK21.00775875
53MAPKAPK30.98481809
54CDK50.97782544
55BCKDK0.97758423
56MAP2K20.97574392
57PDPK10.97093475
58LATS20.94371450
59STK110.94353199
60MAP3K10.92873657
61CAMK1G0.92131689
62SGK30.91563309
63PDK10.91311217
64IRAK20.89725182
65TESK10.89626735
66GRK60.86012817
67DAPK10.85754435
68UHMK10.85711036
69RPS6KA60.83177083
70SCYL20.81949458
71MAP2K30.81837051
72RPS6KL10.81234358
73RPS6KC10.81234358
74PAK30.74803815
75MARK20.74392887
76TAOK20.72765327
77BRAF0.72394110
78MAP3K130.72158853
79PINK10.70659707
80RPS6KA20.69145180
81MAP3K110.68690549
82FGFR40.67905028
83MUSK0.66887305
84HIPK20.66610142
85CAMK40.66442460
86CAMK1D0.66111939
87JAK20.64328118
88PTK2B0.64098531
89DAPK30.63017145
90CAMK10.62458106
91MAPK110.62170517
92MAP3K30.62076006
93CDC42BPA0.61857278
94PTK20.59927102
95RIPK40.59877195
96MAPK120.59677457
97FES0.59559017
98TNK20.59076081
99MAP2K10.58934340
100PRKD10.58761228
101LRRK20.56933223
102PRKCZ0.56423185
103IRAK40.55877352
104PRKAA10.55360032
105PRKCG0.54920090
106MAP2K60.54562309
107MTOR0.53163523
108TESK20.52904457
109ERBB20.51180749
110PRKD20.50697073
111RPS6KA30.48000064
112DDR20.47619721
113GRK50.47461431
114CDK150.47104581
115SGK10.46882567
116DYRK1B0.46433442
117PRKCI0.45730462
118PDK40.45280421
119PDK30.45280421
120MAP4K10.44703975
121LIMK10.44296449
122WNK40.42236055
123RPS6KA10.42080932
124CDK180.41998728
125CDK11A0.41118429
126MAPK150.40610655
127ILK0.40179695
128JAK10.39845720
129PRPF4B0.39820484
130CAMK2B0.39675781
131CDK140.39377394
132FYN0.38478308
133PRKACG0.38178728
134CAMK2G0.38101254
135MAPK80.36471211
136NME20.35496210
137PDGFRB0.33013175
138PRKAA20.32775578

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.80500021
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98411895
3Arginine biosynthesis_Homo sapiens_hsa002202.24094590
4Sulfur relay system_Homo sapiens_hsa041221.98941481
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93329740
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91943875
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83880096
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.81884489
9Bile secretion_Homo sapiens_hsa049761.77300148
10Fructose and mannose metabolism_Homo sapiens_hsa000511.66496090
11Notch signaling pathway_Homo sapiens_hsa043301.63295769
12Synaptic vesicle cycle_Homo sapiens_hsa047211.54791225
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42652339
14Fatty acid degradation_Homo sapiens_hsa000711.40953193
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36202855
16Gastric acid secretion_Homo sapiens_hsa049711.36071038
17Olfactory transduction_Homo sapiens_hsa047401.35336453
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34370106
19Other glycan degradation_Homo sapiens_hsa005111.34365170
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.30285357
21Long-term potentiation_Homo sapiens_hsa047201.29328562
22Butanoate metabolism_Homo sapiens_hsa006501.28522046
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27619143
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27429674
25PPAR signaling pathway_Homo sapiens_hsa033201.24191564
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24035462
27Salivary secretion_Homo sapiens_hsa049701.20622478
28Type II diabetes mellitus_Homo sapiens_hsa049301.20306541
29Circadian entrainment_Homo sapiens_hsa047131.19410206
30Insulin secretion_Homo sapiens_hsa049111.16979431
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16246359
32GABAergic synapse_Homo sapiens_hsa047271.13247721
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10018171
34Tryptophan metabolism_Homo sapiens_hsa003801.09529435
35Fatty acid metabolism_Homo sapiens_hsa012121.07326718
36Glioma_Homo sapiens_hsa052141.05599506
37Histidine metabolism_Homo sapiens_hsa003401.03223713
38Glutamatergic synapse_Homo sapiens_hsa047241.03134169
39Focal adhesion_Homo sapiens_hsa045101.00766044
40Lysine degradation_Homo sapiens_hsa003101.00137013
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00073249
42Amphetamine addiction_Homo sapiens_hsa050310.97186899
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97014927
44Glycosaminoglycan degradation_Homo sapiens_hsa005310.96486313
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96223091
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95808522
47Acute myeloid leukemia_Homo sapiens_hsa052210.95497089
48Oxytocin signaling pathway_Homo sapiens_hsa049210.93837337
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92442541
50Cholinergic synapse_Homo sapiens_hsa047250.92128742
51Dopaminergic synapse_Homo sapiens_hsa047280.91316696
52Protein digestion and absorption_Homo sapiens_hsa049740.90612029
53Carbon metabolism_Homo sapiens_hsa012000.90118511
54GnRH signaling pathway_Homo sapiens_hsa049120.89913208
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89546656
56Axon guidance_Homo sapiens_hsa043600.89036675
57Morphine addiction_Homo sapiens_hsa050320.88350275
58Biosynthesis of amino acids_Homo sapiens_hsa012300.88328926
59Vitamin digestion and absorption_Homo sapiens_hsa049770.87946776
60Insulin resistance_Homo sapiens_hsa049310.87760566
61Fat digestion and absorption_Homo sapiens_hsa049750.87195421
62Propanoate metabolism_Homo sapiens_hsa006400.86967074
63Estrogen signaling pathway_Homo sapiens_hsa049150.86341618
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.86211092
65Glucagon signaling pathway_Homo sapiens_hsa049220.84540841
66mTOR signaling pathway_Homo sapiens_hsa041500.83805529
67Galactose metabolism_Homo sapiens_hsa000520.83759338
68Dilated cardiomyopathy_Homo sapiens_hsa054140.82351577
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81479541
70Arginine and proline metabolism_Homo sapiens_hsa003300.81273406
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.80430794
72Insulin signaling pathway_Homo sapiens_hsa049100.80278622
73Renin secretion_Homo sapiens_hsa049240.80030492
74ECM-receptor interaction_Homo sapiens_hsa045120.79402298
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79196874
76VEGF signaling pathway_Homo sapiens_hsa043700.78673848
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77859307
78Non-small cell lung cancer_Homo sapiens_hsa052230.77493207
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77087975
80Nicotine addiction_Homo sapiens_hsa050330.74611005
81Gap junction_Homo sapiens_hsa045400.73958420
82Vitamin B6 metabolism_Homo sapiens_hsa007500.73345392
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73313886
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71265792
85Complement and coagulation cascades_Homo sapiens_hsa046100.71254682
86Starch and sucrose metabolism_Homo sapiens_hsa005000.71215874
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70989442
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70221327
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.70128377
90Choline metabolism in cancer_Homo sapiens_hsa052310.69990944
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69933523
92Renin-angiotensin system_Homo sapiens_hsa046140.69921466
93Mineral absorption_Homo sapiens_hsa049780.69749585
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69045067
95Dorso-ventral axis formation_Homo sapiens_hsa043200.68099344
96Pyruvate metabolism_Homo sapiens_hsa006200.68027955
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.67347466
98AMPK signaling pathway_Homo sapiens_hsa041520.66719460
99Cocaine addiction_Homo sapiens_hsa050300.66646927
100Tight junction_Homo sapiens_hsa045300.65236716
101MAPK signaling pathway_Homo sapiens_hsa040100.64706533
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64639582
103Amoebiasis_Homo sapiens_hsa051460.64537564
104cAMP signaling pathway_Homo sapiens_hsa040240.63963546
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63031163
106Pentose phosphate pathway_Homo sapiens_hsa000300.62755888
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62435032
108Calcium signaling pathway_Homo sapiens_hsa040200.62353254
109Glycerolipid metabolism_Homo sapiens_hsa005610.61948866
110Prion diseases_Homo sapiens_hsa050200.61648225
111ErbB signaling pathway_Homo sapiens_hsa040120.61229512
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.60697899
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.60627264
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.60440559
115Rap1 signaling pathway_Homo sapiens_hsa040150.60373092
116ABC transporters_Homo sapiens_hsa020100.60089017
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59299703
118beta-Alanine metabolism_Homo sapiens_hsa004100.58364693
119Fatty acid biosynthesis_Homo sapiens_hsa000610.58098955
120Endometrial cancer_Homo sapiens_hsa052130.57922569
121Thyroid hormone synthesis_Homo sapiens_hsa049180.57886510
122Phenylalanine metabolism_Homo sapiens_hsa003600.57884507
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55801568
124Pancreatic secretion_Homo sapiens_hsa049720.54412725
125Chronic myeloid leukemia_Homo sapiens_hsa052200.52791719
126Caffeine metabolism_Homo sapiens_hsa002320.52183419
127Renal cell carcinoma_Homo sapiens_hsa052110.48985394
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48696655
129Long-term depression_Homo sapiens_hsa047300.47845169
130Melanogenesis_Homo sapiens_hsa049160.47247665
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47169680
132Bladder cancer_Homo sapiens_hsa052190.47025386
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46577509

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »