EPN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.13712699
2surfactant homeostasis (GO:0043129)6.60317271
3desmosome organization (GO:0002934)6.56115830
4glomerular visceral epithelial cell development (GO:0072015)5.76581244
5hemidesmosome assembly (GO:0031581)5.73330357
6chemical homeostasis within a tissue (GO:0048875)5.43877204
7glomerular epithelial cell development (GO:0072310)5.28773029
8sarcomere organization (GO:0045214)5.20681626
9plasma membrane repair (GO:0001778)5.09074090
10ventricular cardiac muscle cell action potential (GO:0086005)4.98468917
11Golgi transport vesicle coating (GO:0048200)4.92045152
12COPI coating of Golgi vesicle (GO:0048205)4.92045152
13ear development (GO:0043583)4.81410493
14regulation of cardioblast differentiation (GO:0051890)4.75075783
15epithelial cell maturation (GO:0002070)4.73218800
16positive regulation of keratinocyte differentiation (GO:0045618)4.65589819
17glomerular basement membrane development (GO:0032836)4.64771467
18negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.42429705
19biotin metabolic process (GO:0006768)4.33363902
20positive regulation of epidermal cell differentiation (GO:0045606)4.30771688
21keratinization (GO:0031424)4.26940071
22cell communication involved in cardiac conduction (GO:0086065)4.22597409
23cardiac myofibril assembly (GO:0055003)4.21267841
24epithelial cell-cell adhesion (GO:0090136)4.19172125
25regulation of water loss via skin (GO:0033561)4.17460955
26negative regulation of cell size (GO:0045792)3.99272138
27negative regulation of potassium ion transmembrane transport (GO:1901380)3.98760063
28regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.97832851
29establishment of skin barrier (GO:0061436)3.95163912
30gap junction assembly (GO:0016264)3.86682225
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.83178499
32positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.82507165
33endothelial cell chemotaxis (GO:0035767)3.74710837
34apical protein localization (GO:0045176)3.74583609
35regulation of cell proliferation involved in kidney development (GO:1901722)3.73489389
36proline biosynthetic process (GO:0006561)3.70057944
37myofibril assembly (GO:0030239)3.69295827
38positive regulation of Cdc42 GTPase activity (GO:0043089)3.67845087
39branching involved in mammary gland duct morphogenesis (GO:0060444)3.67632895
40actomyosin structure organization (GO:0031032)3.67580734
41multicellular organismal water homeostasis (GO:0050891)3.65003083
42retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.60006777
43maternal placenta development (GO:0001893)3.59112810
44negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.58355973
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.57830690
46semaphorin-plexin signaling pathway (GO:0071526)3.54825298
47cardiac muscle contraction (GO:0060048)3.53710197
48branching involved in prostate gland morphogenesis (GO:0060442)3.53380372
49interferon-gamma secretion (GO:0072643)3.52346028
50asymmetric protein localization (GO:0008105)3.48894563
51regulation of keratinocyte differentiation (GO:0045616)3.46243341
52mammary gland epithelial cell differentiation (GO:0060644)3.42900214
53negative regulation of cell fate commitment (GO:0010454)3.42814758
54regulation of heart rate by cardiac conduction (GO:0086091)3.42659247
55ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.41088064
56regulation of fatty acid beta-oxidation (GO:0031998)3.40431073
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40092449
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.39454465
59epidermis development (GO:0008544)3.39023086
60calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.37856243
61epidermal cell differentiation (GO:0009913)3.35615181
62cardiac muscle cell development (GO:0055013)3.32823160
63regulation of skeletal muscle contraction (GO:0014819)3.30582369
64positive regulation of epidermis development (GO:0045684)3.29504598
65establishment of apical/basal cell polarity (GO:0035089)3.29159632
66prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.29055018
67lung epithelium development (GO:0060428)3.28754904
68hair cycle (GO:0042633)3.27219129
69molting cycle (GO:0042303)3.27219129
70cardiac muscle cell action potential involved in contraction (GO:0086002)3.26745420
71branching involved in salivary gland morphogenesis (GO:0060445)3.26647126
72keratinocyte development (GO:0003334)3.26147834
73cardiac right ventricle morphogenesis (GO:0003215)3.22567528
74primary alcohol catabolic process (GO:0034310)3.20932491
75face development (GO:0060324)3.18883405
76cardiac muscle tissue morphogenesis (GO:0055008)3.18853046
77actin-myosin filament sliding (GO:0033275)3.18363132
78muscle filament sliding (GO:0030049)3.18363132
79cardiac cell development (GO:0055006)3.17745425
80pattern specification involved in kidney development (GO:0061004)3.15691843
81regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.15467429
82prostate gland epithelium morphogenesis (GO:0060740)3.15251300
83planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15226630
84response to food (GO:0032094)3.14977305
85cell-substrate junction assembly (GO:0007044)3.14217894
86activation of Rac GTPase activity (GO:0032863)3.14126129
87cardiac muscle cell action potential (GO:0086001)3.13270329
88protein localization to endosome (GO:0036010)3.08968295
89cardiac conduction (GO:0061337)3.05973113
90membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05856885
91glandular epithelial cell differentiation (GO:0002067)3.05380057
92polarized epithelial cell differentiation (GO:0030859)3.04699831
93regulation of cholesterol biosynthetic process (GO:0045540)3.04641426
94regulation of actin filament-based movement (GO:1903115)3.02915061
95positive regulation of cellular amine metabolic process (GO:0033240)3.01985641
96membrane repolarization during action potential (GO:0086011)3.01835921
97iron ion import (GO:0097286)2.99892630
98water homeostasis (GO:0030104)2.97840473
99muscle tissue morphogenesis (GO:0060415)2.97401388
100establishment of planar polarity (GO:0001736)2.97062855
101establishment of tissue polarity (GO:0007164)2.97062855
102tricarboxylic acid cycle (GO:0006099)2.95549473
103vascular endothelial growth factor signaling pathway (GO:0038084)2.93991084
104intermediate filament organization (GO:0045109)2.93471255
105atrioventricular valve morphogenesis (GO:0003181)2.93313560
106negative regulation of keratinocyte proliferation (GO:0010839)2.92125246
107actin-mediated cell contraction (GO:0070252)2.91886240
108regulation of p38MAPK cascade (GO:1900744)2.91182446
109amyloid precursor protein catabolic process (GO:0042987)2.90927953
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.90719298
111ectoderm development (GO:0007398)2.90654995
112regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.89057470
113regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88780770
114proline metabolic process (GO:0006560)2.88655787
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.88255780
116columnar/cuboidal epithelial cell development (GO:0002066)2.88063004
117tight junction assembly (GO:0070830)2.87930350
118regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.87593472
119linoleic acid metabolic process (GO:0043651)2.87380319
120heart trabecula formation (GO:0060347)2.87237714
121negative regulation of cell fate specification (GO:0009996)2.87056384
122glutathione biosynthetic process (GO:0006750)2.84737138
123regulation of interleukin-13 production (GO:0032656)2.84297879
124renal filtration (GO:0097205)2.83505842
125keratinocyte proliferation (GO:0043616)2.82990006
126carnitine transmembrane transport (GO:1902603)2.82127600
127cell communication by electrical coupling (GO:0010644)2.79990584
128keratinocyte differentiation (GO:0030216)2.79479480
129cell differentiation involved in embryonic placenta development (GO:0060706)2.79426601
130cell-substrate adherens junction assembly (GO:0007045)2.79399699
131focal adhesion assembly (GO:0048041)2.79399699
132myelin maintenance (GO:0043217)2.78794383
133adherens junction assembly (GO:0034333)2.78424310
134norepinephrine metabolic process (GO:0042415)2.77866788
135regulation of receptor binding (GO:1900120)2.77031217
136cell-cell junction assembly (GO:0007043)2.75772343
137outflow tract septum morphogenesis (GO:0003148)2.75527104
138relaxation of cardiac muscle (GO:0055119)2.74553771
139regulation of glomerular filtration (GO:0003093)2.74477724
140peptide cross-linking (GO:0018149)2.74292614
141dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.73792167
142carnitine transport (GO:0015879)2.73235338
143amino-acid betaine transport (GO:0015838)2.73235338
144regulation of hippo signaling (GO:0035330)2.73090816
145regulation of tight junction assembly (GO:2000810)2.72233113
146hepatocyte apoptotic process (GO:0097284)2.71938812
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.71651578
148skin morphogenesis (GO:0043589)2.70012004
149phosphate ion homeostasis (GO:0055062)2.67905884
150trivalent inorganic anion homeostasis (GO:0072506)2.67905884
151mesonephros development (GO:0001823)2.67739187
152striated muscle contraction (GO:0006941)2.60504794
153epithelial cell differentiation involved in prostate gland development (GO:0060742)2.58244752
154renal system process involved in regulation of blood volume (GO:0001977)2.57688622
155actin filament-based movement (GO:0030048)2.56865972
156regulation of the force of heart contraction (GO:0002026)2.54595474
157mesodermal cell differentiation (GO:0048333)2.54431428
158cell adhesion mediated by integrin (GO:0033627)2.53964755
159regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.53414112
160regulation of membrane repolarization (GO:0060306)2.53236741
161coronary vasculature morphogenesis (GO:0060977)2.52477594
162respiratory tube development (GO:0030323)2.50555464
163regulation of heart rate (GO:0002027)2.50225546
164lymphangiogenesis (GO:0001946)2.46520374
165cell migration involved in sprouting angiogenesis (GO:0002042)2.45372226
166hypotonic response (GO:0006971)2.44190910
167membrane budding (GO:0006900)2.43417401
168lung lobe morphogenesis (GO:0060463)2.43197353
169membrane repolarization (GO:0086009)2.41974673
170sodium ion export (GO:0071436)2.41168923
171regulation of striated muscle contraction (GO:0006942)2.40341871
172intestinal epithelial cell development (GO:0060576)2.39157182
173carnitine shuttle (GO:0006853)2.39138517
174positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.38741168
175virion attachment to host cell (GO:0019062)2.38407890
176adhesion of symbiont to host cell (GO:0044650)2.38407890
177positive regulation of sodium ion transport (GO:0010765)2.36967658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.13561260
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.66581420
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.30598979
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98706544
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.88321051
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87852516
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.84557149
8ZNF263_19887448_ChIP-Seq_K562_Human2.77629651
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.55950559
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.41468829
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.30432445
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24708580
13TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.04018231
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02328267
15SOX9_24532713_ChIP-Seq_HFSC_Mouse1.92895644
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91774286
17TBX20_22328084_ChIP-Seq_HEART_Mouse1.91250193
18TBX20_22080862_ChIP-Seq_HEART_Mouse1.91250193
19FOXO3_23340844_ChIP-Seq_DLD1_Human1.82143722
20CLOCK_20551151_ChIP-Seq_293T_Human1.81545797
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79453603
22RACK7_27058665_Chip-Seq_MCF-7_Human1.77780543
23CDX2_20551321_ChIP-Seq_CACO-2_Human1.74449913
24PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74156065
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71913036
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69729584
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.68466255
28AHR_22903824_ChIP-Seq_MCF-7_Human1.65911897
29* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.65806931
30ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65280075
31* SOX2_20726797_ChIP-Seq_SW620_Human1.65193131
32CHD1_26751641_Chip-Seq_LNCaP_Human1.64422523
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62459248
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62459248
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.60015279
36CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.58741947
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58324692
38SMC4_20622854_ChIP-Seq_HELA_Human1.53950814
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51601877
40GATA4_25053715_ChIP-Seq_YYC3_Human1.47472962
41P68_20966046_ChIP-Seq_HELA_Human1.46455856
42AR_21909140_ChIP-Seq_LNCAP_Human1.46403382
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45789670
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43433082
45* ATF3_27146783_Chip-Seq_COLON_Human1.42664451
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41982687
47KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41667904
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41651577
49* ELF5_23300383_ChIP-Seq_T47D_Human1.40594221
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39803880
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38731079
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37395743
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36147014
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34772205
55KDM5A_27292631_Chip-Seq_BREAST_Human1.34081391
56CJUN_26792858_Chip-Seq_BT549_Human1.32342995
57FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.32186759
58* GATA6_25053715_ChIP-Seq_YYC3_Human1.31994359
59TCF7_22412390_ChIP-Seq_EML_Mouse1.31246441
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28999650
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28007768
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.27300656
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26850775
64LXR_22292898_ChIP-Seq_THP-1_Human1.26436115
65KDM2B_26808549_Chip-Seq_K562_Human1.25618447
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.25560296
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25410358
68KLF5_25053715_ChIP-Seq_YYC3_Human1.24747459
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23637663
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.23412704
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23375615
72* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23320493
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23207899
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23045586
75GATA3_24758297_ChIP-Seq_MCF-7_Human1.19679835
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19327066
77* TP63_22573176_ChIP-Seq_HFKS_Human1.18801361
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.18066455
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17808650
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17038483
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16035248
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.15103808
83TCF4_18268006_ChIP-ChIP_LS174T_Human1.14050656
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13988935
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12255913
86JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12073842
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.10708267
88VDR_21846776_ChIP-Seq_THP-1_Human1.08568488
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08460939
90KDM2B_26808549_Chip-Seq_DND41_Human1.08404354
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06090681
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.03869678
93RARB_24833708_ChIP-Seq_LIVER_Mouse1.03269042
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03007982
95SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02066805
96* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02050294
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02025399
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01956653
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01657648
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01572895
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01126357
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01126357
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00676471
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.00407281
105FOXA1_25552417_ChIP-Seq_VCAP_Human1.00082738
106FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98697601
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98584661
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98455368
109MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97801482
110EGR1_19032775_ChIP-ChIP_M12_Human0.97584960
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96820286
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95746314
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95703056
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95300402
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95213631
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94425271
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.93410966
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93131767
119GATA1_22025678_ChIP-Seq_K562_Human0.92987728
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92298998
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.92167900
122BCOR_27268052_Chip-Seq_Bcells_Human0.91797240
123* TP63_23658742_ChIP-Seq_EP156T_Human0.91774613
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91740352
125TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91226806
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.91038925
127* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90187799
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89814514
129CREB1_26743006_Chip-Seq_LNCaP_Human0.89646110
130* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88993508
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88769408
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88590978
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88195740
134* CTCF_27219007_Chip-Seq_Bcells_Human0.87815442
135NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87475136
136MYC_22102868_ChIP-Seq_BL_Human0.86845966
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86097537
138* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85491620
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84652404
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84410944
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.82918739
142JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82858623
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82503860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.26513803
2MP0010234_abnormal_vibrissa_follicle4.11725933
3MP0002796_impaired_skin_barrier3.88006219
4MP0002837_dystrophic_cardiac_calcinosis3.79810864
5MP0004036_abnormal_muscle_relaxation2.81864638
6MP0009780_abnormal_chondrocyte_physiolo2.79313796
7MP0005275_abnormal_skin_tensile2.78786105
8MP0000751_myopathy2.75050019
9MP0004782_abnormal_surfactant_physiolog2.68871655
10MP0008004_abnormal_stomach_pH2.59988011
11MP0000537_abnormal_urethra_morphology2.53750890
12MP0003646_muscle_fatigue2.49097497
13MP0004215_abnormal_myocardial_fiber2.46937249
14MP0000579_abnormal_nail_morphology2.37727087
15MP0004381_abnormal_hair_follicle2.36328730
16MP0003705_abnormal_hypodermis_morpholog2.31471674
17MP0003566_abnormal_cell_adhesion2.29509944
18MP0010678_abnormal_skin_adnexa2.20926800
19MP0005501_abnormal_skin_physiology2.14846782
20MP0005330_cardiomyopathy2.12902367
21MP0001958_emphysema2.08904525
22MP0004272_abnormal_basement_membrane2.05456392
23MP0002972_abnormal_cardiac_muscle2.04525638
24MP0000383_abnormal_hair_follicle1.94631466
25MP0005623_abnormal_meninges_morphology1.93017848
26MP0006138_congestive_heart_failure1.92752903
27MP0002098_abnormal_vibrissa_morphology1.86803690
28MP0008775_abnormal_heart_ventricle1.86184761
29MP0002234_abnormal_pharynx_morphology1.85346010
30MP0000749_muscle_degeneration1.82315643
31MP0004087_abnormal_muscle_fiber1.80618112
32MP0005076_abnormal_cell_differentiation1.76030394
33MP0005385_cardiovascular_system_phenoty1.75251525
34MP0001544_abnormal_cardiovascular_syste1.75251525
35MP0001873_stomach_inflammation1.73239490
36MP0004484_altered_response_of1.71352652
37MP0010368_abnormal_lymphatic_system1.69310008
38MP0010630_abnormal_cardiac_muscle1.65933223
39MP0000627_abnormal_mammary_gland1.63250504
40MP0000678_abnormal_parathyroid_gland1.59961804
41MP0000750_abnormal_muscle_regeneration1.57884611
42MP0003941_abnormal_skin_development1.56435853
43MP0000427_abnormal_hair_cycle1.56424270
44MP0005409_darkened_coat_color1.56052097
45MP0005083_abnormal_biliary_tract1.54785255
46MP0005451_abnormal_body_composition1.53866971
47MP0003137_abnormal_impulse_conducting1.52516637
48MP0005248_abnormal_Harderian_gland1.51635495
49MP0004043_abnormal_pH_regulation1.50561067
50MP0005620_abnormal_muscle_contractility1.49960638
51MP0001216_abnormal_epidermal_layer1.48082452
52MP0004185_abnormal_adipocyte_glucose1.44942544
53MP0002060_abnormal_skin_morphology1.42598239
54MP0002166_altered_tumor_susceptibility1.42463138
55MP0003828_pulmonary_edema1.39640311
56MP0003315_abnormal_perineum_morphology1.35535037
57MP0000762_abnormal_tongue_morphology1.34143349
58MP0002249_abnormal_larynx_morphology1.32788881
59MP0002295_abnormal_pulmonary_circulatio1.28770339
60MP0004130_abnormal_muscle_cell1.28146292
61MP0010771_integument_phenotype1.28133363
62MP0003453_abnormal_keratinocyte_physiol1.27981220
63MP0000647_abnormal_sebaceous_gland1.27270360
64MP0003191_abnormal_cellular_cholesterol1.26795961
65MP0002009_preneoplasia1.24601421
66MP0000538_abnormal_urinary_bladder1.23907413
67MP0001756_abnormal_urination1.21961789
68MP0009931_abnormal_skin_appearance1.21072736
69MP0010030_abnormal_orbit_morphology1.20828066
70MP0000462_abnormal_digestive_system1.18817037
71MP0001879_abnormal_lymphatic_vessel1.16690869
72MP0004085_abnormal_heartbeat1.14773053
73MP0001765_abnormal_ion_homeostasis1.14164246
74MP0000566_synostosis1.12770924
75MP0000534_abnormal_ureter_morphology1.10305238
76MP0003300_gastrointestinal_ulcer1.08068922
77MP0005165_increased_susceptibility_to1.07469143
78MP0009643_abnormal_urine_homeostasis1.05433857
79MP0000377_abnormal_hair_follicle1.04930309
80MP0008875_abnormal_xenobiotic_pharmacok1.04526534
81MP0001881_abnormal_mammary_gland1.02421912
82MP0002269_muscular_atrophy1.01742352
83MP0004947_skin_inflammation1.00575708
84MP0000467_abnormal_esophagus_morphology1.00240746
85MP0000747_muscle_weakness1.00161952
86MP0002106_abnormal_muscle_physiology0.99999846
87MP0005666_abnormal_adipose_tissue0.95457197
88MP0003936_abnormal_reproductive_system0.95400394
89MP0004264_abnormal_extraembryonic_tissu0.94948642
90MP0006054_spinal_hemorrhage0.93951803
91MP0003123_paternal_imprinting0.93844455
92MP0002254_reproductive_system_inflammat0.92866541
93MP0004858_abnormal_nervous_system0.92339168
94MP0009384_cardiac_valve_regurgitation0.92337354
95MP0002089_abnormal_postnatal_growth/wei0.92334121
96MP0005310_abnormal_salivary_gland0.91127410
97MP0000367_abnormal_coat/_hair0.90914186
98MP0000343_altered_response_to0.90171790
99MP0002006_tumorigenesis0.90026205
100MP0004233_abnormal_muscle_weight0.89781874
101MP0000470_abnormal_stomach_morphology0.89775776
102MP0001919_abnormal_reproductive_system0.89672301
103MP0005187_abnormal_penis_morphology0.89191768
104MP0001849_ear_inflammation0.88947237
105MP0001346_abnormal_lacrimal_gland0.88787999
106MP0002136_abnormal_kidney_physiology0.87656149
107MP0003950_abnormal_plasma_membrane0.86314669
108MP0002138_abnormal_hepatobiliary_system0.86106148
109MP0003221_abnormal_cardiomyocyte_apopto0.85796314
110MP0005023_abnormal_wound_healing0.85431841
111MP0002133_abnormal_respiratory_system0.84618431
112MP0005388_respiratory_system_phenotype0.84618431
113MP0001784_abnormal_fluid_regulation0.80821139
114MP0005646_abnormal_pituitary_gland0.80753941
115MP0009053_abnormal_anal_canal0.79939516
116MP0005369_muscle_phenotype0.79414010
117MP0010352_gastrointestinal_tract_polyps0.78584164
118MP0005167_abnormal_blood-brain_barrier0.78421887
119MP0002909_abnormal_adrenal_gland0.78408032
120MP0000759_abnormal_skeletal_muscle0.78017233
121MP0001664_abnormal_digestion0.77658233
122MP0000230_abnormal_systemic_arterial0.76910305
123MP0005375_adipose_tissue_phenotype0.76479507
124MP0003942_abnormal_urinary_system0.76280324
125MP0005377_hearing/vestibular/ear_phenot0.75217134
126MP0003878_abnormal_ear_physiology0.75217134
127MP0000613_abnormal_salivary_gland0.75042112
128MP0002128_abnormal_blood_circulation0.74381276
129MP0008961_abnormal_basal_metabolism0.74000968
130MP0003045_fibrosis0.73670484
131MP0003567_abnormal_fetal_cardiomyocyte0.73396092
132MP0003115_abnormal_respiratory_system0.71617133
133MP0003638_abnormal_response/metabolism_0.70170887
134MP0005367_renal/urinary_system_phenotyp0.69935857
135MP0000516_abnormal_urinary_system0.69935857
136MP0008995_early_reproductive_senescence0.69751536
137MP0005647_abnormal_sex_gland0.69599251
138MP0001727_abnormal_embryo_implantation0.69035508
139MP0002653_abnormal_ependyma_morphology0.66177704
140MP0009672_abnormal_birth_weight0.65371900
141MP0000477_abnormal_intestine_morphology0.65341877
142MP0003693_abnormal_embryo_hatching0.65312481
143MP0002111_abnormal_tail_morphology0.64416996
144MP0001666_abnormal_nutrient_absorption0.64401197
145MP0005408_hypopigmentation0.62670714
146MP0003011_delayed_dark_adaptation0.60715414
147MP0008260_abnormal_autophagy0.60378189
148MP0005075_abnormal_melanosome_morpholog0.60230211
149MP0002822_catalepsy0.57480186
150MP0005058_abnormal_lysosome_morphology0.57254053
151MP0004019_abnormal_vitamin_homeostasis0.57008205
152MP0001340_abnormal_eyelid_morphology0.56879271
153MP0005636_abnormal_mineral_homeostasis0.54248543
154MP0001191_abnormal_skin_condition0.51676369
155MP0002896_abnormal_bone_mineralization0.50833513
156MP0002108_abnormal_muscle_morphology0.49315147

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.86184033
2Sudden death (HP:0001699)5.61555202
3Ventricular tachycardia (HP:0004756)5.31847859
4Septate vagina (HP:0001153)4.69045113
5Hyporeflexia of lower limbs (HP:0002600)4.38580259
6Lip pit (HP:0100267)4.38071342
7Interstitial pulmonary disease (HP:0006530)4.32534536
8Congenital ichthyosiform erythroderma (HP:0007431)4.28281603
9Muscle fiber splitting (HP:0003555)4.25597345
10Ventricular fibrillation (HP:0001663)4.07709388
11Onycholysis (HP:0001806)4.07366882
12Flat acetabular roof (HP:0003180)4.00622883
13Syncope (HP:0001279)3.85943247
14Hyperactive renin-angiotensin system (HP:0000841)3.84797731
15Pili torti (HP:0003777)3.60751127
16Amelogenesis imperfecta (HP:0000705)3.59909085
17Fragile nails (HP:0001808)3.59866684
18Sparse lateral eyebrow (HP:0005338)3.59666695
19Atrial fibrillation (HP:0005110)3.55846622
20Increased connective tissue (HP:0009025)3.47668550
21Abnormality of the distal phalanges of the toes (HP:0010182)3.43933001
22Abnormality of chloride homeostasis (HP:0011422)3.42723705
23Woolly hair (HP:0002224)3.34549142
24Concave nail (HP:0001598)3.33238292
25Primary atrial arrhythmia (HP:0001692)3.32373101
26Gout (HP:0001997)3.30625966
27Testicular atrophy (HP:0000029)3.30181728
28Mesangial abnormality (HP:0001966)3.24857356
29Supraventricular arrhythmia (HP:0005115)3.17978430
30Focal segmental glomerulosclerosis (HP:0000097)3.17554972
31Supraventricular tachycardia (HP:0004755)3.17437265
32Plantar hyperkeratosis (HP:0007556)3.13590151
33Ventricular arrhythmia (HP:0004308)3.12633674
34Milia (HP:0001056)3.12629715
35Germ cell neoplasia (HP:0100728)3.07068694
36Exercise-induced muscle cramps (HP:0003710)3.06409233
37Lipoatrophy (HP:0100578)3.04858958
38Glomerulosclerosis (HP:0000096)3.04159447
39Calf muscle hypertrophy (HP:0008981)3.04130940
40Palpitations (HP:0001962)3.03191996
41Renal salt wasting (HP:0000127)3.02511394
42Thin bony cortex (HP:0002753)3.01286103
43Abnormality of the calf musculature (HP:0001430)2.94363498
44Abnormality of secondary sexual hair (HP:0009888)2.93251127
45Abnormality of the axillary hair (HP:0100134)2.93251127
46Exercise-induced myalgia (HP:0003738)2.92434131
47Bundle branch block (HP:0011710)2.91882890
48Distal lower limb muscle weakness (HP:0009053)2.91120073
49Conjunctival hamartoma (HP:0100780)2.87850781
50Prolonged QT interval (HP:0001657)2.86565061
51Abnormality of the left ventricular outflow tract (HP:0011103)2.83924477
52Subaortic stenosis (HP:0001682)2.83924477
53Broad face (HP:0000283)2.82926763
54Hypotrichosis (HP:0001006)2.81428260
55Palmoplantar keratoderma (HP:0000982)2.72906865
56J-shaped sella turcica (HP:0002680)2.69002334
57Abnormality of the dental root (HP:0006486)2.65998071
58Taurodontia (HP:0000679)2.65998071
59Abnormality of permanent molar morphology (HP:0011071)2.65998071
60Hypokalemic alkalosis (HP:0001949)2.63614976
61Difficulty climbing stairs (HP:0003551)2.63317181
62Muscle hypertrophy of the lower extremities (HP:0008968)2.61459344
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.59722754
64Asymmetry of the thorax (HP:0001555)2.59440640
65Atrophic scars (HP:0001075)2.58931864
66Asymmetric septal hypertrophy (HP:0001670)2.58342837
67Dilated cardiomyopathy (HP:0001644)2.58068021
68EMG: myopathic abnormalities (HP:0003458)2.52621482
69Hyperaldosteronism (HP:0000859)2.51483840
70Testicular neoplasm (HP:0010788)2.49802585
71Sparse eyelashes (HP:0000653)2.49323475
72Difficulty running (HP:0009046)2.48493749
73Abnormality of the salivary glands (HP:0010286)2.44005090
74Broad metatarsal (HP:0001783)2.43463358
75Abnormality of molar (HP:0011077)2.39148259
76Abnormality of molar morphology (HP:0011070)2.39148259
77Chronic bronchitis (HP:0004469)2.38886649
78Abnormal tarsal ossification (HP:0008369)2.38001169
79Cervical subluxation (HP:0003308)2.35384211
80Palmoplantar hyperkeratosis (HP:0000972)2.33105209
81Abnormal atrioventricular conduction (HP:0005150)2.32639654
82Short nail (HP:0001799)2.31947763
83Atrioventricular block (HP:0001678)2.31939481
84Flattened epiphyses (HP:0003071)2.31347164
85Tubulointerstitial fibrosis (HP:0005576)2.31286691
86Oral leukoplakia (HP:0002745)2.30670037
87Erythema (HP:0010783)2.30452682
88Rectal prolapse (HP:0002035)2.30155775
89Thick nail (HP:0001805)2.29641297
90Spinal cord compression (HP:0002176)2.28952437
91Curly hair (HP:0002212)2.28690162
92Heart block (HP:0012722)2.27946786
93Myoglobinuria (HP:0002913)2.27144297
94Abnormality of the dental pulp (HP:0006479)2.26641398
95Nail dystrophy (HP:0008404)2.25198258
96Mildly elevated creatine phosphokinase (HP:0008180)2.23568256
97Metabolic alkalosis (HP:0200114)2.20926590
98Respiratory distress (HP:0002098)2.19956272
99Abnormality of nail color (HP:0100643)2.19134277
100Abnormality of renin-angiotensin system (HP:0000847)2.15140059
101Rapidly progressive (HP:0003678)2.13991619
102Hypoparathyroidism (HP:0000829)2.13965079
103Lymphangioma (HP:0100764)2.12866312
104Congenital glaucoma (HP:0001087)2.10870046
105Palmar hyperkeratosis (HP:0010765)2.09161896
106Hyperacusis (HP:0010780)2.08490077
107Limb-girdle muscle atrophy (HP:0003797)2.07369535
108Absent eyelashes (HP:0000561)2.06541080
109Hypoplasia of dental enamel (HP:0006297)2.06372412
110Corneal erosion (HP:0200020)2.05305896
111Pterygium (HP:0001059)2.04916120
112Erythroderma (HP:0001019)2.03914384
113Macroorchidism (HP:0000053)2.03794967
114Ectropion (HP:0000656)2.03487745
115Hamartoma of the eye (HP:0010568)2.02461549
116Abnormality of the gastric mucosa (HP:0004295)2.01238190
117Sudden cardiac death (HP:0001645)1.98606125
118Abdominal distention (HP:0003270)1.98469091
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.98409316
120Popliteal pterygium (HP:0009756)1.97929821
121Abnormal blistering of the skin (HP:0008066)1.96617733
122Alopecia of scalp (HP:0002293)1.96293803
123Microretrognathia (HP:0000308)1.93907578
124Breast carcinoma (HP:0003002)1.92201805
125Bronchomalacia (HP:0002780)1.92125210
126Hyperparathyroidism (HP:0000843)1.91082100
127Esophageal varix (HP:0002040)1.88175605
128Visceral angiomatosis (HP:0100761)1.88003711
129Obstructive sleep apnea (HP:0002870)1.87949245
130Abnormality of carpal bone ossification (HP:0006257)1.87806021
131Abnormality of renal excretion (HP:0011036)1.87598735
132Acanthosis nigricans (HP:0000956)1.87555513
133Tachypnea (HP:0002789)1.87441704
134Abnormal EKG (HP:0003115)1.87118622
135Congenital malformation of the right heart (HP:0011723)1.86364294
136Double outlet right ventricle (HP:0001719)1.86364294
137Increased variability in muscle fiber diameter (HP:0003557)1.86182781
138Abnormality of the distal phalanx of the thumb (HP:0009617)1.85981185
139Hyperkalemia (HP:0002153)1.85536662
140Hypomagnesemia (HP:0002917)1.84948676
141Bifid scrotum (HP:0000048)1.84345269
142Increased IgE level (HP:0003212)1.82673506
143Neonatal death (HP:0003811)1.81216438
144Short 1st metacarpal (HP:0010034)1.79635221
145Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.79635221
146Polycythemia (HP:0001901)1.79594803
147Cerebral aneurysm (HP:0004944)1.79273695
148Abnormal hair laboratory examination (HP:0003328)1.78206867
149Abnormality of the 1st metacarpal (HP:0010009)1.77949167
150Myotonia (HP:0002486)1.77929472
151Depressed nasal tip (HP:0000437)1.77845295
152Tubular atrophy (HP:0000092)1.77064357
153Enlarged penis (HP:0000040)1.76510023
154Dehydration (HP:0001944)1.75907360
155Advanced eruption of teeth (HP:0006288)1.75789693
156Hypohidrosis (HP:0000966)1.75589510
157Increased circulating renin level (HP:0000848)1.75351310
158Selective tooth agenesis (HP:0001592)1.74910128
159Natal tooth (HP:0000695)1.74527016
160Tetany (HP:0001281)1.74463759
161Stridor (HP:0010307)1.73908384
162Scapular winging (HP:0003691)1.73352332
163Partial duplication of thumb phalanx (HP:0009944)1.72890522
164Ankle contracture (HP:0006466)1.72843403
165Ridged nail (HP:0001807)1.71936659
166Absent hair (HP:0002298)1.71673655
167Micronodular cirrhosis (HP:0001413)1.69731349
168Diaphragmatic weakness (HP:0009113)1.66058590
169Seborrheic dermatitis (HP:0001051)1.65459607
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.65080993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.41050586
2LMTK24.11529495
3TRIB33.28751801
4TTN3.12521414
5MYLK2.86010740
6WNK42.82754925
7SMG12.79448401
8MST42.48202746
9FER2.38669962
10CAMK1D2.19345256
11PRKD32.07545669
12PKN22.05843398
13EPHB22.05645349
14RIPK12.03617259
15STK392.03530693
16MAPKAPK31.98711336
17STK241.95169351
18TIE11.94409113
19PHKG11.93510297
20PHKG21.93510297
21SCYL21.92522818
22MST1R1.89775483
23LATS11.87740488
24LRRK21.83023484
25EPHB11.69877774
26IRAK31.68392869
27ERN11.66323599
28NME21.63842163
29MAP3K31.62032633
30DMPK1.61705733
31PRKD21.61095797
32PDK41.54700335
33PDK31.54700335
34TNK21.53910483
35CAMK1G1.52147590
36MUSK1.50474522
37STK38L1.50011772
38ICK1.49525613
39RPS6KB21.49074846
40PTK61.45500867
41TGFBR21.45275126
42OXSR11.42075415
43MAP3K21.39675795
44PAK41.35967149
45TESK21.34809228
46BCKDK1.26716039
47PDGFRA1.23770706
48MAP2K21.20626479
49NEK11.19197718
50PDK21.14613777
51CDK121.11565937
52LATS21.10001895
53PAK31.08478220
54PTK21.03432981
55PRKD11.02651892
56NEK61.00595327
57ILK0.99800087
58CDK70.98638909
59MAPK150.98148232
60MAP3K120.97804931
61EIF2AK10.97579156
62GRK60.97504603
63FGFR20.97258706
64ROCK10.97229611
65PIK3CA0.97010598
66WNK10.96177189
67WNK30.95650686
68MAP2K10.94687612
69MET0.91068862
70STK380.90294137
71MAP3K70.89472986
72PIM20.88519504
73FGFR40.86164732
74TRPM70.86139938
75NME10.84811019
76VRK20.81141238
77KSR20.77610571
78ROCK20.73689892
79OBSCN0.73430664
80MARK20.72848025
81MAP3K90.72484699
82CDC42BPA0.71925842
83SIK30.71526514
84EPHA30.70479155
85STK100.70364096
86PRKG20.70101938
87CHUK0.69564748
88NEK90.68616006
89SIK10.67503207
90ARAF0.66569050
91MAP3K10.66192670
92IRAK20.66045088
93PDGFRB0.65083569
94DDR20.64860508
95CAMK2D0.62031887
96PTK2B0.54689865
97MAP2K30.54441860
98FRK0.52944319
99MAP3K110.52924187
100MAP3K60.52778220
101PRKCE0.52100149
102RET0.51793201
103PRKCI0.51748062
104FGFR10.49785361
105AKT30.49482537
106TAOK10.48925996
107TESK10.48821439
108PDPK10.46780291
109MAP2K60.43863670
110TAF10.42007636
111LIMK10.41467958
112MAPKAPK20.39953726
113EEF2K0.38268986
114BMX0.38113322
115TGFBR10.37922822
116RPS6KB10.37579711
117CAMK10.36761569
118RPS6KA20.36558286
119DAPK30.36454207
120KDR0.35709203
121SGK30.35706838
122AKT20.35132750
123CAMK2G0.34942932
124ZAP700.33171876
125GSK3A0.32957700
126ERBB20.32779147
127MTOR0.32323019
128NTRK10.31959122
129RPS6KL10.31202827
130RPS6KC10.31202827
131HIPK20.29756956
132PRKAA20.26828951
133RPS6KA60.26648295
134TBK10.26471554
135MAPK80.26213297
136CAMKK10.24598790
137PBK0.22469277
138CAMK2B0.22356923
139PRKAA10.21553489
140DAPK10.19766211
141AURKA0.19740922
142PRKCZ0.18073992
143AURKB0.17471240
144CSNK1A10.14193307
145RPS6KA40.13303876

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29712211
2Phenylalanine metabolism_Homo sapiens_hsa003602.76411358
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.74232726
4Dilated cardiomyopathy_Homo sapiens_hsa054142.72364425
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.66642381
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.41011227
7Cardiac muscle contraction_Homo sapiens_hsa042602.40033528
8ECM-receptor interaction_Homo sapiens_hsa045122.25079840
9Histidine metabolism_Homo sapiens_hsa003402.07694700
10Tight junction_Homo sapiens_hsa045302.05684403
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87891009
12Fatty acid degradation_Homo sapiens_hsa000711.83996958
13Adherens junction_Homo sapiens_hsa045201.72102256
14Propanoate metabolism_Homo sapiens_hsa006401.69691326
15Notch signaling pathway_Homo sapiens_hsa043301.64234162
16Focal adhesion_Homo sapiens_hsa045101.61781841
17Sphingolipid metabolism_Homo sapiens_hsa006001.58673565
18Mineral absorption_Homo sapiens_hsa049781.55115421
19Tyrosine metabolism_Homo sapiens_hsa003501.53596049
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42251670
21Gastric acid secretion_Homo sapiens_hsa049711.41998359
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40743757
23Amoebiasis_Homo sapiens_hsa051461.36979547
24Protein digestion and absorption_Homo sapiens_hsa049741.36513944
25Prostate cancer_Homo sapiens_hsa052151.34456893
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.34164298
27mTOR signaling pathway_Homo sapiens_hsa041501.33140190
28Choline metabolism in cancer_Homo sapiens_hsa052311.32956236
29Hepatitis C_Homo sapiens_hsa051601.31276218
30Steroid biosynthesis_Homo sapiens_hsa001001.31049637
31Oxidative phosphorylation_Homo sapiens_hsa001901.28248429
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27331302
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26954023
34Acute myeloid leukemia_Homo sapiens_hsa052211.25779040
35ABC transporters_Homo sapiens_hsa020101.24703328
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24324817
37Small cell lung cancer_Homo sapiens_hsa052221.24013353
38Hippo signaling pathway_Homo sapiens_hsa043901.23981329
39Other glycan degradation_Homo sapiens_hsa005111.20927508
40Carbon metabolism_Homo sapiens_hsa012001.19827492
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18325146
42Ovarian steroidogenesis_Homo sapiens_hsa049131.17289040
43Viral myocarditis_Homo sapiens_hsa054161.16749469
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15393204
45Fatty acid metabolism_Homo sapiens_hsa012121.13415850
46Arginine and proline metabolism_Homo sapiens_hsa003301.13377232
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12313105
48ErbB signaling pathway_Homo sapiens_hsa040121.11811126
49Proteoglycans in cancer_Homo sapiens_hsa052051.11643032
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.09671719
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08567914
52Bladder cancer_Homo sapiens_hsa052191.06830916
53Pancreatic secretion_Homo sapiens_hsa049721.05056514
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02885032
55Vitamin digestion and absorption_Homo sapiens_hsa049771.01766217
56Parkinsons disease_Homo sapiens_hsa050121.01510551
57Sulfur relay system_Homo sapiens_hsa041220.99156457
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98502751
59Alzheimers disease_Homo sapiens_hsa050100.98280151
60Pentose phosphate pathway_Homo sapiens_hsa000300.97454509
61Linoleic acid metabolism_Homo sapiens_hsa005910.94989972
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93700015
63Renin-angiotensin system_Homo sapiens_hsa046140.93262968
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.92371857
65Pyruvate metabolism_Homo sapiens_hsa006200.91656332
66Lysine degradation_Homo sapiens_hsa003100.91571176
67Non-small cell lung cancer_Homo sapiens_hsa052230.88722617
68Insulin resistance_Homo sapiens_hsa049310.87070337
69N-Glycan biosynthesis_Homo sapiens_hsa005100.87023128
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86425971
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84035208
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83508739
73VEGF signaling pathway_Homo sapiens_hsa043700.83035014
74Chronic myeloid leukemia_Homo sapiens_hsa052200.81834070
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.81438168
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.80371393
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79646065
78Chemical carcinogenesis_Homo sapiens_hsa052040.78901523
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76411675
80Renal cell carcinoma_Homo sapiens_hsa052110.75675051
81Fatty acid elongation_Homo sapiens_hsa000620.74742684
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74730289
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74220164
84Basal cell carcinoma_Homo sapiens_hsa052170.73638410
85Thyroid hormone synthesis_Homo sapiens_hsa049180.73355690
86Endometrial cancer_Homo sapiens_hsa052130.72774311
87Collecting duct acid secretion_Homo sapiens_hsa049660.71170539
88Dorso-ventral axis formation_Homo sapiens_hsa043200.70996123
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70402838
90Thyroid cancer_Homo sapiens_hsa052160.70197431
91Glioma_Homo sapiens_hsa052140.70144282
92Rap1 signaling pathway_Homo sapiens_hsa040150.69993289
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.69886335
94Arginine biosynthesis_Homo sapiens_hsa002200.69480231
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69478813
96Prolactin signaling pathway_Homo sapiens_hsa049170.68204268
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67518559
98Insulin signaling pathway_Homo sapiens_hsa049100.67320523
99Biosynthesis of amino acids_Homo sapiens_hsa012300.66764307
100Bile secretion_Homo sapiens_hsa049760.66670482
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.66077928
102PPAR signaling pathway_Homo sapiens_hsa033200.65434288
103Galactose metabolism_Homo sapiens_hsa000520.65218424
104Vibrio cholerae infection_Homo sapiens_hsa051100.64994387
105Toxoplasmosis_Homo sapiens_hsa051450.64791439
106Fatty acid biosynthesis_Homo sapiens_hsa000610.63477081
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63465954
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63261560
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.62788492
110Salivary secretion_Homo sapiens_hsa049700.62136174
111Axon guidance_Homo sapiens_hsa043600.61285484
112HIF-1 signaling pathway_Homo sapiens_hsa040660.61167831
113Salmonella infection_Homo sapiens_hsa051320.61025163
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59269600
115Hedgehog signaling pathway_Homo sapiens_hsa043400.59050315
116Sulfur metabolism_Homo sapiens_hsa009200.58231880
117Glutathione metabolism_Homo sapiens_hsa004800.58188247
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57347216
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55938199
120Renin secretion_Homo sapiens_hsa049240.54136014
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.52447769
122Melanogenesis_Homo sapiens_hsa049160.52444919
123beta-Alanine metabolism_Homo sapiens_hsa004100.52305883
124Pathways in cancer_Homo sapiens_hsa052000.49929998
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49407448
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49348444
127Pancreatic cancer_Homo sapiens_hsa052120.48931261
128Fat digestion and absorption_Homo sapiens_hsa049750.48779864
129Huntingtons disease_Homo sapiens_hsa050160.48614112
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48612000
131GnRH signaling pathway_Homo sapiens_hsa049120.47985367
132Fructose and mannose metabolism_Homo sapiens_hsa000510.47555630
133Lysosome_Homo sapiens_hsa041420.47101870
134Estrogen signaling pathway_Homo sapiens_hsa049150.46635835
135Arachidonic acid metabolism_Homo sapiens_hsa005900.46596193
136* Endocytosis_Homo sapiens_hsa041440.46089652
137Platelet activation_Homo sapiens_hsa046110.45984003
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45498560
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45191055
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44901091
141AMPK signaling pathway_Homo sapiens_hsa041520.44625825
142Melanoma_Homo sapiens_hsa052180.44167980
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43621318
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43391267
145Inositol phosphate metabolism_Homo sapiens_hsa005620.42812294
146Glucagon signaling pathway_Homo sapiens_hsa049220.41317892
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39786632

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