EPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma lipoprotein particle assembly (GO:0034377)8.76189679
2very-low-density lipoprotein particle assembly (GO:0034379)8.21721005
3regulation of cholesterol esterification (GO:0010872)7.98831180
4protein-lipid complex assembly (GO:0065005)7.76065460
5negative regulation of fibrinolysis (GO:0051918)7.58757023
6intestinal cholesterol absorption (GO:0030299)7.50290917
7low-density lipoprotein particle remodeling (GO:0034374)7.14342403
8neutrophil activation involved in immune response (GO:0002283)6.98653676
9cholesterol efflux (GO:0033344)6.92429745
10high-density lipoprotein particle remodeling (GO:0034375)6.85636328
11protein carboxylation (GO:0018214)6.84570630
12peptidyl-glutamic acid carboxylation (GO:0017187)6.84570630
13protein-lipid complex remodeling (GO:0034368)6.80194785
14macromolecular complex remodeling (GO:0034367)6.80194785
15plasma lipoprotein particle remodeling (GO:0034369)6.80194785
16regulation of fibrinolysis (GO:0051917)6.64032303
17negative regulation of amyloid precursor protein catabolic process (GO:1902992)6.29707356
18plasma lipoprotein particle organization (GO:0071827)6.28776308
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.23711876
20reverse cholesterol transport (GO:0043691)6.19804461
21regulation of protein activation cascade (GO:2000257)6.18534050
22plasma lipoprotein particle clearance (GO:0034381)6.08500401
23regulation of complement activation (GO:0030449)5.92054704
24protein-lipid complex subunit organization (GO:0071825)5.89157848
25phospholipid efflux (GO:0033700)5.85769843
26positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.65023651
27negative regulation of cholesterol transport (GO:0032375)5.64461528
28negative regulation of sterol transport (GO:0032372)5.64461528
29neuronal action potential propagation (GO:0019227)5.64353718
30blood coagulation, intrinsic pathway (GO:0007597)5.19734335
31regulation of apoptotic cell clearance (GO:2000425)5.08931495
32regulation of plasminogen activation (GO:0010755)5.08772636
33* negative regulation of calcium ion transport into cytosol (GO:0010523)4.97192839
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.94300369
35proline metabolic process (GO:0006560)4.78361880
36central nervous system myelination (GO:0022010)4.76401528
37axon ensheathment in central nervous system (GO:0032291)4.76401528
38regulation of amyloid precursor protein catabolic process (GO:1902991)4.73806010
39protein maturation by protein folding (GO:0022417)4.66921245
40intestinal absorption (GO:0050892)4.64104703
41regulation of cholesterol homeostasis (GO:2000188)4.57316651
42complement activation, alternative pathway (GO:0006957)4.46089622
43lipoprotein metabolic process (GO:0042157)4.32116053
44tumor necrosis factor-mediated signaling pathway (GO:0033209)4.31035526
45cholesterol transport (GO:0030301)4.31005438
46sterol transport (GO:0015918)4.31005438
47positive regulation of steroid metabolic process (GO:0045940)4.29429617
48cholesterol homeostasis (GO:0042632)4.25021336
49sterol homeostasis (GO:0055092)4.19996363
50acute-phase response (GO:0006953)4.19535482
51regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.12783081
52negative regulation of phosphoprotein phosphatase activity (GO:0032515)4.11815920
53diacylglycerol metabolic process (GO:0046339)4.11811697
54negative regulation of lipase activity (GO:0060192)4.11717917
55regulation of bile acid biosynthetic process (GO:0070857)4.11558515
56vesicle docking involved in exocytosis (GO:0006904)4.11247899
57positive regulation of triglyceride lipase activity (GO:0061365)4.09627558
58positive regulation of lipoprotein lipase activity (GO:0051006)4.09627558
59glutamate metabolic process (GO:0006536)4.09089411
60membrane repolarization (GO:0086009)4.07449962
61mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.06396055
62negative regulation of protein activation cascade (GO:2000258)4.04715312
63proline biosynthetic process (GO:0006561)3.92016093
64low-density lipoprotein particle clearance (GO:0034383)3.84685267
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.82105489
66cholesterol biosynthetic process (GO:0006695)3.81849048
67GDP-mannose metabolic process (GO:0019673)3.80604553
68acylglycerol homeostasis (GO:0055090)3.80428166
69triglyceride homeostasis (GO:0070328)3.80428166
70negative regulation of norepinephrine secretion (GO:0010700)3.75715949
71synaptic vesicle exocytosis (GO:0016079)3.75236583
72potassium ion export (GO:0071435)3.74872935
73protein localization to synapse (GO:0035418)3.74467539
74N-terminal protein amino acid acetylation (GO:0006474)3.74463308
75regulation of heterotypic cell-cell adhesion (GO:0034114)3.72382751
76layer formation in cerebral cortex (GO:0021819)3.71049394
77regulation of cholesterol biosynthetic process (GO:0045540)3.70541538
78positive regulation of fatty acid biosynthetic process (GO:0045723)3.70397015
79cell migration in hindbrain (GO:0021535)3.63293143
80renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.60427285
81fibrinolysis (GO:0042730)3.55349163
82positive regulation of blood coagulation (GO:0030194)3.52490585
83positive regulation of hemostasis (GO:1900048)3.52490585
84innervation (GO:0060384)3.49110083
85positive regulation of hormone metabolic process (GO:0032352)3.48285409
86dicarboxylic acid biosynthetic process (GO:0043650)3.47495731
87negative regulation of blood coagulation (GO:0030195)3.42155904
88negative regulation of hemostasis (GO:1900047)3.42155904
89regulation of beta-amyloid formation (GO:1902003)3.42030379
90negative regulation of protein autophosphorylation (GO:0031953)3.40696358
91cell communication by electrical coupling (GO:0010644)3.40566922
92sterol biosynthetic process (GO:0016126)3.40096895
93vesicle docking (GO:0048278)3.38003054
94lipid homeostasis (GO:0055088)3.36662474
95L-phenylalanine metabolic process (GO:0006558)3.36349292
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.36349292
97lung epithelium development (GO:0060428)3.32897242
98fatty acid elongation (GO:0030497)3.32601802
99cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31640302
100regulation of humoral immune response (GO:0002920)3.31017264
101L-ascorbic acid metabolic process (GO:0019852)3.28681055
102chaperone-mediated protein transport (GO:0072321)3.28263887
103regulation of cytokine secretion involved in immune response (GO:0002739)3.27213133
104regulation of ARF protein signal transduction (GO:0032012)3.27154097
105protein activation cascade (GO:0072376)3.26042645
106regulation of norepinephrine secretion (GO:0014061)3.24246410
107L-phenylalanine catabolic process (GO:0006559)3.23328053
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.23328053
109positive regulation of coagulation (GO:0050820)3.22915555
110cellular zinc ion homeostasis (GO:0006882)3.19217804
111embryonic retina morphogenesis in camera-type eye (GO:0060059)3.19057383
112negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.14340385
113negative regulation of coagulation (GO:0050819)3.13667973
114phospholipid homeostasis (GO:0055091)3.13608035
115leukocyte mediated cytotoxicity (GO:0001909)3.11503916
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11170041
117negative regulation of sodium ion transport (GO:0010766)3.08560466
118synaptic vesicle maturation (GO:0016188)3.07019100
119positive regulation of hormone biosynthetic process (GO:0046886)3.05914096
120acute inflammatory response (GO:0002526)3.05151540
121neutral lipid catabolic process (GO:0046461)3.04158323
122acylglycerol catabolic process (GO:0046464)3.04158323
123positive regulation of extracellular matrix organization (GO:1903055)3.03951522
124cytidine metabolic process (GO:0046087)3.03610607
125cytidine catabolic process (GO:0006216)3.03610607
126cytidine deamination (GO:0009972)3.03610607
127calcium-mediated signaling using intracellular calcium source (GO:0035584)3.03399575
128N-terminal protein amino acid modification (GO:0031365)3.02683729
129positive regulation of lipid catabolic process (GO:0050996)3.02492239
130negative regulation of lipid transport (GO:0032369)2.93960948
131negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.93830281
132cellular potassium ion homeostasis (GO:0030007)2.93604859
133positive regulation of cellular amine metabolic process (GO:0033240)2.93506805
134long-term memory (GO:0007616)2.93076883
135peptidyl-glutamic acid modification (GO:0018200)2.92750879
136neutrophil activation (GO:0042119)2.91469234
137protein polyglutamylation (GO:0018095)2.88952426
138peroxisome fission (GO:0016559)2.86551133
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86536449
140negative regulation of wound healing (GO:0061045)2.86020108
141trivalent inorganic anion homeostasis (GO:0072506)2.85710135
142phosphate ion homeostasis (GO:0055062)2.85710135
143cholesterol metabolic process (GO:0008203)2.85295070
144modified amino acid transport (GO:0072337)2.85071958
145glutamine family amino acid biosynthetic process (GO:0009084)2.84224498
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.83871903
147suckling behavior (GO:0001967)2.83870867
148lipoprotein transport (GO:0042953)2.83678535
149C21-steroid hormone metabolic process (GO:0008207)2.82649734
150regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82124330
151regulation of mast cell degranulation (GO:0043304)2.74194870
152endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.72164254
153mating behavior (GO:0007617)2.71996280
154sodium ion export (GO:0071436)2.71275226
155establishment of mitochondrion localization (GO:0051654)2.69751738
156negative regulation of leukocyte chemotaxis (GO:0002689)2.67611869
157activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.66389564
158negative regulation of axonogenesis (GO:0050771)2.65894860
159pyrimidine-containing compound transmembrane transport (GO:0072531)2.65355276
160neuron cell-cell adhesion (GO:0007158)2.64082330
161cellular ketone body metabolic process (GO:0046950)2.63525334
162pyrimidine nucleoside catabolic process (GO:0046135)2.63412344
163dendrite morphogenesis (GO:0048813)2.63283988
164regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.61959002
165sarcoplasmic reticulum calcium ion transport (GO:0070296)2.61773143
166negative regulation of heart rate (GO:0010459)2.61680541
167membrane docking (GO:0022406)2.59848434
168negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.59844265
169SMAD protein complex assembly (GO:0007183)2.58750258
170long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.58617949
171aldehyde catabolic process (GO:0046185)2.57455081
172glutathione biosynthetic process (GO:0006750)2.55522972
173regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55131164
174acetyl-CoA metabolic process (GO:0006084)2.52777939
175receptor catabolic process (GO:0032801)2.52351417
176negative regulation of microtubule polymerization (GO:0031115)2.51917108
177granulocyte activation (GO:0036230)2.48050753
178response to pheromone (GO:0019236)2.47954356
179cell killing (GO:0001906)2.47007840
180positive regulation of potassium ion transmembrane transport (GO:1901381)2.46142185
181behavioral response to pain (GO:0048266)2.45951031
182regulation of cellular amide metabolic process (GO:0034248)2.44825162
183glutamate secretion (GO:0014047)2.43201202
184regulation of mast cell activation involved in immune response (GO:0033006)2.42888186
185G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42676874
186regulation of dendritic spine morphogenesis (GO:0061001)2.42403155
187regulation of axon regeneration (GO:0048679)2.41274911
188regulation of neuron projection regeneration (GO:0070570)2.41274911
189negative regulation of organelle assembly (GO:1902116)2.41174964
190L-glutamate transport (GO:0015813)2.41150428
191regulation of monocyte differentiation (GO:0045655)2.39659051
192negative regulation of hormone secretion (GO:0046888)2.39643087
193apical protein localization (GO:0045176)2.38311414
194regulation of protein kinase A signaling (GO:0010738)2.37853838
195proline transport (GO:0015824)2.37817747
196fatty-acyl-CoA biosynthetic process (GO:0046949)2.34539917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.76778000
2PPARA_22158963_ChIP-Seq_LIVER_Mouse4.40348123
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.77933657
4FOXA2_19822575_ChIP-Seq_HepG2_Human3.70877586
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.49179097
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.38106885
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.33975729
8ZNF263_19887448_ChIP-Seq_K562_Human3.29919023
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.24022459
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.07129912
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97515398
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88250455
13* HNF4A_19822575_ChIP-Seq_HepG2_Human2.83549441
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.82321429
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78848337
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72895478
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72895478
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67904515
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61611417
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51665724
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44546935
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44182007
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37341481
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37257945
25TAF15_26573619_Chip-Seq_HEK293_Human2.35337059
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.34878907
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.33899466
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.29639052
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29077035
30EZH2_22144423_ChIP-Seq_EOC_Human2.28009326
31SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26477034
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16522372
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.12146733
34STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05518820
35* ERG_21242973_ChIP-ChIP_JURKAT_Human2.05130113
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.97256863
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.97227609
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96625235
39CDX2_20551321_ChIP-Seq_CACO-2_Human1.94507488
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.93846636
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92375287
42CLOCK_20551151_ChIP-Seq_293T_Human1.91188881
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.89867504
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86504006
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.86052854
46STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.84161219
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.83007447
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.75155255
49LXR_22292898_ChIP-Seq_THP-1_Human1.75029068
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74884843
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.70614721
52GBX2_23144817_ChIP-Seq_PC3_Human1.68688896
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.64285072
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.64285072
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.64285072
56GATA4_25053715_ChIP-Seq_YYC3_Human1.63726825
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.60621833
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.59312616
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56816008
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56011043
61GATA6_25053715_ChIP-Seq_YYC3_Human1.54753792
62REST_18959480_ChIP-ChIP_MESCs_Mouse1.54681732
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.53562663
64AR_21909140_ChIP-Seq_LNCAP_Human1.49320781
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.48487225
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.44915899
67ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44061417
68REST_21632747_ChIP-Seq_MESCs_Mouse1.43405656
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40176496
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38852807
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.38180743
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36209890
73* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34635105
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33968663
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.33693692
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32446532
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.30482961
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24501299
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24460556
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23405206
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22234111
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21340975
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20534944
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19866702
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19503175
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18983312
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18127291
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17595329
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.16360347
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15714579
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14658157
92RARA_24833708_ChIP-Seq_LIVER_Mouse1.13572789
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13438936
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13436872
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13356885
96CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13218398
97EOMES_21245162_ChIP-Seq_HESCs_Human1.13044184
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12942771
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.12891897
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11377952
101RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10665492
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.10218891
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09132187
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05616547
105* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04448548
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04249128
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04126849
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.01872476
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99331945
110KDM2B_26808549_Chip-Seq_K562_Human0.98746704
111CTCF_27219007_Chip-Seq_Bcells_Human0.97546342
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97437695
113EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95423127
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.95230819
115DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94337903
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.93485967
117NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.92558723
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92330559
119NCOR_22424771_ChIP-Seq_293T_Human0.91797793
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91493998
121* P68_20966046_ChIP-Seq_HELA_Human0.91091978
122SMC4_20622854_ChIP-Seq_HELA_Human0.90823737
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.90803121
124* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89690424
125SMAD4_21799915_ChIP-Seq_A2780_Human0.89408933
126JUN_21703547_ChIP-Seq_K562_Human0.89405922
127CBP_20019798_ChIP-Seq_JUKART_Human0.88697315
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88697315
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87959334
130* RXR_22158963_ChIP-Seq_LIVER_Mouse0.87634361
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87395097
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87254149
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.86336156
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85918826
135CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85858345
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85735162
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.85733213
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85702965
139TP53_22127205_ChIP-Seq_IMR90_Human0.84504800
140MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83567504
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82888671
142SA1_27219007_Chip-Seq_Bcells_Human0.82480004
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.82199900
144DROSHA_22980978_ChIP-Seq_HELA_Human0.82064568
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81269942
146PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81200936
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.81188594
148SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80498738
149RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80258698
150P300_19829295_ChIP-Seq_ESCs_Human0.80190458
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79517817
152GABP_19822575_ChIP-Seq_HepG2_Human0.79248586
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79082706
154CTCF_20526341_ChIP-Seq_ESCs_Human0.78886926
155RARB_24833708_ChIP-Seq_LIVER_Mouse0.78843038
156ETS1_21867929_ChIP-Seq_TH2_Mouse0.78610449
157SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78024245
158KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77986757
159PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77485779
160EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.76647199
161FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76512361
162JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76434891
163EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.76308182
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.76092914
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.75529776
166CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74391414
167RACK7_27058665_Chip-Seq_MCF-7_Human0.74009857
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.73732585
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.73700428
170FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.72006583
171MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71649468
172SOX11_22085726_ChIP-Seq_ESNs_Mouse0.71643476
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.71589561
174SOX17_20123909_ChIP-Seq_XEN_Mouse0.70180241
175KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68819361
176ATF3_27146783_Chip-Seq_COLON_Human0.68301898
177SOX2_20726797_ChIP-Seq_SW620_Human0.67887072
178CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67139366
179* FOXP1_21924763_ChIP-Seq_HESCs_Human0.67071756
180TCF3_18692474_ChIP-Seq_MEFs_Mouse0.67010778
181CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66164639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia6.43380889
2MP0005083_abnormal_biliary_tract6.02988296
3MP0004859_abnormal_synaptic_plasticity4.01399974
4MP0004858_abnormal_nervous_system3.91497178
5MP0001666_abnormal_nutrient_absorption3.90650998
6MP0003123_paternal_imprinting3.64559271
7MP0008961_abnormal_basal_metabolism3.23889484
8MP0003329_amyloid_beta_deposits2.91423766
9MP0000566_synostosis2.80657026
10MP0002735_abnormal_chemical_nociception2.80162681
11MP0002734_abnormal_mechanical_nocicepti2.75797331
12MP0009840_abnormal_foam_cell2.57078923
13MP0002064_seizures2.55196390
14MP0008875_abnormal_xenobiotic_pharmacok2.50524797
15MP0004264_abnormal_extraembryonic_tissu2.20709569
16MP0005377_hearing/vestibular/ear_phenot2.19612970
17MP0003878_abnormal_ear_physiology2.19612970
18MP0005085_abnormal_gallbladder_physiolo2.15924443
19MP0003635_abnormal_synaptic_transmissio2.07441116
20MP0003880_abnormal_central_pattern2.03589986
21MP0002089_abnormal_postnatal_growth/wei1.97945591
22MP0005451_abnormal_body_composition1.95794459
23MP0003172_abnormal_lysosome_physiology1.92800897
24MP0000604_amyloidosis1.87916958
25MP0005409_darkened_coat_color1.84682737
26MP0002184_abnormal_innervation1.82522732
27MP0001529_abnormal_vocalization1.82067720
28MP0003632_abnormal_nervous_system1.80270343
29MP0000462_abnormal_digestive_system1.73497510
30MP0003252_abnormal_bile_duct1.73264985
31MP0003191_abnormal_cellular_cholesterol1.70794740
32MP0000639_abnormal_adrenal_gland1.69863313
33MP0000955_abnormal_spinal_cord1.69384968
34MP0009745_abnormal_behavioral_response1.67239632
35MP0000920_abnormal_myelination1.60730776
36MP0001905_abnormal_dopamine_level1.60315978
37MP0004142_abnormal_muscle_tone1.56213544
38MP0002132_abnormal_respiratory_system1.55619082
39MP0000609_abnormal_liver_physiology1.55396289
40MP0005360_urolithiasis1.55153212
41MP0003942_abnormal_urinary_system1.54354426
42MP0005646_abnormal_pituitary_gland1.53632568
43MP0003121_genomic_imprinting1.52029977
44MP0001299_abnormal_eye_distance/1.50687190
45MP0005379_endocrine/exocrine_gland_phen1.50504390
46MP0002733_abnormal_thermal_nociception1.50424456
47MP0001440_abnormal_grooming_behavior1.49151848
48MP0002063_abnormal_learning/memory/cond1.46997790
49MP0003806_abnormal_nucleotide_metabolis1.45833084
50MP0005408_hypopigmentation1.45187859
51MP0000751_myopathy1.45031933
52MP0010329_abnormal_lipoprotein_level1.44683015
53MP0001970_abnormal_pain_threshold1.42766240
54MP0002272_abnormal_nervous_system1.40977343
55MP0002837_dystrophic_cardiac_calcinosis1.40059102
56MP0004145_abnormal_muscle_electrophysio1.38862537
57MP0005332_abnormal_amino_acid1.37077840
58MP0003315_abnormal_perineum_morphology1.34741233
59MP0005076_abnormal_cell_differentiation1.34560964
60MP0002163_abnormal_gland_morphology1.34187180
61MP0002751_abnormal_autonomic_nervous1.30432031
62MP0002822_catalepsy1.29230425
63MP0005365_abnormal_bile_salt1.27560526
64MP0001968_abnormal_touch/_nociception1.26979831
65MP0003567_abnormal_fetal_cardiomyocyte1.25219920
66MP0002139_abnormal_hepatobiliary_system1.23528350
67MP0003122_maternal_imprinting1.21459367
68MP0000778_abnormal_nervous_system1.18593995
69MP0009046_muscle_twitch1.16855590
70MP0001485_abnormal_pinna_reflex1.16534933
71MP0009379_abnormal_foot_pigmentation1.15742029
72MP0010368_abnormal_lymphatic_system1.15671406
73MP0004811_abnormal_neuron_physiology1.14877674
74MP0003634_abnormal_glial_cell1.14569099
75MP0006054_spinal_hemorrhage1.13433977
76MP0002572_abnormal_emotion/affect_behav1.13415254
77MP0001486_abnormal_startle_reflex1.13120065
78MP0003690_abnormal_glial_cell1.10757344
79MP0004019_abnormal_vitamin_homeostasis1.09871446
80MP0001324_abnormal_eye_pigmentation1.09800000
81MP0005670_abnormal_white_adipose1.07436399
82MP0003183_abnormal_peptide_metabolism1.06504552
83MP0000598_abnormal_liver_morphology1.05875580
84MP0002067_abnormal_sensory_capabilities1.05462818
85MP0003941_abnormal_skin_development1.03716033
86MP0002066_abnormal_motor_capabilities/c1.03132961
87MP0002909_abnormal_adrenal_gland1.02612696
88MP0002249_abnormal_larynx_morphology1.02209515
89MP0002736_abnormal_nociception_after1.00823511
90MP0001764_abnormal_homeostasis0.99252652
91MP0002160_abnormal_reproductive_system0.98844475
92MP0005464_abnormal_platelet_physiology0.98747259
93MP0002882_abnormal_neuron_morphology0.97622991
94MP0003646_muscle_fatigue0.97272411
95MP0002938_white_spotting0.96147828
96MP0009250_abnormal_appendicular_skeleto0.95182195
97MP0005084_abnormal_gallbladder_morpholo0.95095742
98MP0001348_abnormal_lacrimal_gland0.94740739
99MP0000163_abnormal_cartilage_morphology0.94481363
100MP0003300_gastrointestinal_ulcer0.94352572
101MP0002098_abnormal_vibrissa_morphology0.93966843
102MP0005423_abnormal_somatic_nervous0.91283002
103MP0003631_nervous_system_phenotype0.91214295
104MP0002282_abnormal_trachea_morphology0.90527990
105MP0003890_abnormal_embryonic-extraembry0.90498746
106MP0005187_abnormal_penis_morphology0.88905634
107MP0005257_abnormal_intraocular_pressure0.88506431
108MP0004085_abnormal_heartbeat0.88303353
109MP0005166_decreased_susceptibility_to0.87464334
110MP0005330_cardiomyopathy0.87393078
111MP0004043_abnormal_pH_regulation0.87360740
112MP0003283_abnormal_digestive_organ0.86770446
113* MP0005636_abnormal_mineral_homeostasis0.86459825
114MP0001270_distended_abdomen0.84286163
115MP0005381_digestive/alimentary_phenotyp0.83821413
116MP0004134_abnormal_chest_morphology0.83605188
117MP0004742_abnormal_vestibular_system0.83518091
118MP0002115_abnormal_skeleton_extremities0.83515017
119MP0002697_abnormal_eye_size0.83057720
120MP0001346_abnormal_lacrimal_gland0.82070649
121MP0003137_abnormal_impulse_conducting0.81887859
122MP0002229_neurodegeneration0.81268006
123MP0005410_abnormal_fertilization0.81118837
124MP0005623_abnormal_meninges_morphology0.81083074
125MP0005220_abnormal_exocrine_pancreas0.80528577
126MP0003879_abnormal_hair_cell0.79898801
127MP0002752_abnormal_somatic_nervous0.79409509
128MP0005058_abnormal_lysosome_morphology0.78653740
129MP0004885_abnormal_endolymph0.77979366
130MP0002109_abnormal_limb_morphology0.77282188
131MP0001915_intracranial_hemorrhage0.77074471
132MP0003115_abnormal_respiratory_system0.76623725
133MP0009642_abnormal_blood_homeostasis0.76409298
134MP0005319_abnormal_enzyme/_coenzyme0.76187087
135MP0003195_calcinosis0.75820053
136MP0002069_abnormal_eating/drinking_beha0.73740451
137MP0002118_abnormal_lipid_homeostasis0.73708870
138MP0000003_abnormal_adipose_tissue0.72565180
139MP0000678_abnormal_parathyroid_gland0.70928385
140MP0009384_cardiac_valve_regurgitation0.70863836
141MP0002092_abnormal_eye_morphology0.70611110
142MP0003385_abnormal_body_wall0.69888930
143MP0004272_abnormal_basement_membrane0.68229391
144MP0000534_abnormal_ureter_morphology0.67866183
145MP0001963_abnormal_hearing_physiology0.67474073
146MP0001730_embryonic_growth_arrest0.67389766
147MP0005310_abnormal_salivary_gland0.67368511
148MP0001664_abnormal_digestion0.66636407
149MP0001661_extended_life_span0.66482265
150MP0004036_abnormal_muscle_relaxation0.65570375
151MP0003943_abnormal_hepatobiliary_system0.65328930
152MP0000749_muscle_degeneration0.63562944
153MP0003075_altered_response_to0.62967282
154MP0006276_abnormal_autonomic_nervous0.62772648
155MP0002896_abnormal_bone_mineralization0.62415179
156MP0001286_abnormal_eye_development0.61637532
157MP0002876_abnormal_thyroid_physiology0.61422933
158MP0005167_abnormal_blood-brain_barrier0.61325353
159MP0002086_abnormal_extraembryonic_tissu0.60598735
160MP0009780_abnormal_chondrocyte_physiolo0.59541361
161MP0003868_abnormal_feces_composition0.58412051
162MP0009643_abnormal_urine_homeostasis0.56708988
163MP0000516_abnormal_urinary_system0.56631041
164MP0005367_renal/urinary_system_phenotyp0.56631041
165MP0005584_abnormal_enzyme/coenzyme_acti0.55948890
166MP0003953_abnormal_hormone_level0.54351952
167MP0009672_abnormal_birth_weight0.54246038
168MP0009115_abnormal_fat_cell0.53385677
169MP0002233_abnormal_nose_morphology0.51315026
170MP0008260_abnormal_autophagy0.51205976
171MP0003656_abnormal_erythrocyte_physiolo0.50969574
172MP0000858_altered_metastatic_potential0.50947860
173MP0004185_abnormal_adipocyte_glucose0.49657975
174MP0009697_abnormal_copulation0.46591430
175MP0001293_anophthalmia0.46355963

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)7.92096254
2Prolonged partial thromboplastin time (HP:0003645)7.44448404
3Hypobetalipoproteinemia (HP:0003563)6.64911760
4Joint hemorrhage (HP:0005261)6.28741839
5Myokymia (HP:0002411)6.07016596
6Popliteal pterygium (HP:0009756)6.03883703
7Amyotrophic lateral sclerosis (HP:0007354)6.03747382
8Abnormality of the common coagulation pathway (HP:0010990)5.63139670
9Spontaneous abortion (HP:0005268)5.51058152
10Complement deficiency (HP:0004431)5.34535199
11Increased serum ferritin (HP:0003281)4.96080499
12Obstructive sleep apnea (HP:0002870)4.71742982
13Upper motor neuron abnormality (HP:0002127)4.59917661
14Xanthomatosis (HP:0000991)4.55977850
15Hypercholesterolemia (HP:0003124)4.46394287
16Hypolipoproteinemia (HP:0010981)4.45627603
17Sensory axonal neuropathy (HP:0003390)4.40443805
18Atonic seizures (HP:0010819)4.37192399
19Glomerulonephritis (HP:0000099)4.36571428
20Abnormality of the aortic arch (HP:0012303)4.32933175
21Abnormality of iron homeostasis (HP:0011031)4.06091446
22Abnormality of complement system (HP:0005339)4.00253497
23Abnormality of macrophages (HP:0004311)3.90472344
24Nasolacrimal duct obstruction (HP:0000579)3.83894803
25Rimmed vacuoles (HP:0003805)3.80651961
26Atrophy/Degeneration involving motor neurons (HP:0007373)3.72742699
27Episodic fever (HP:0001954)3.67409289
28Hemorrhage of the eye (HP:0011885)3.64000016
29Abnormality of the phalanges of the hallux (HP:0010057)3.63166476
30Acanthocytosis (HP:0001927)3.61770032
31Systemic lupus erythematosus (HP:0002725)3.60875261
32Abnormality of the vocal cords (HP:0008777)3.50970696
33Fat malabsorption (HP:0002630)3.45787522
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43485998
35Broad alveolar ridges (HP:0000187)3.43257264
36Shoulder girdle muscle weakness (HP:0003547)3.42367268
37Abnormality of transition element cation homeostasis (HP:0011030)3.38604723
38Abnormality of the lacrimal duct (HP:0011481)3.37512986
39Menorrhagia (HP:0000132)3.34966816
40Abnormality of carpal bone ossification (HP:0006257)3.32897700
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.30784329
42Febrile seizures (HP:0002373)3.29315483
43Epidermoid cyst (HP:0200040)3.26809573
44Abnormal hemoglobin (HP:0011902)3.26762034
45Abnormal hair whorl (HP:0010721)3.24834533
46Intrahepatic cholestasis (HP:0001406)3.22281460
47Gingival bleeding (HP:0000225)3.11641269
48Asymmetry of the thorax (HP:0001555)3.07608193
49Pancreatic islet-cell hyperplasia (HP:0004510)3.05951287
50Hepatoblastoma (HP:0002884)3.04090484
51Flared iliac wings (HP:0002869)3.02573201
52Absence seizures (HP:0002121)2.97916685
53Abnormality of the epiphysis of the femoral head (HP:0010574)2.90964775
54Small epiphyses (HP:0010585)2.90827108
55Purpura (HP:0000979)2.89149061
56Irregular epiphyses (HP:0010582)2.86945874
57Diastasis recti (HP:0001540)2.86786496
58Xerostomia (HP:0000217)2.85893496
59Pterygium (HP:0001059)2.82641683
60Vaginal fistula (HP:0004320)2.81748177
61Abnormality of the nasolacrimal system (HP:0000614)2.81405227
62Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.79791712
63Abnormality of femoral epiphyses (HP:0006499)2.79791712
64Abnormality of the parietal bone (HP:0002696)2.74149213
65Hepatosplenomegaly (HP:0001433)2.72923476
66Epiphyseal dysplasia (HP:0002656)2.71483935
67Vascular calcification (HP:0004934)2.70611278
68Malnutrition (HP:0004395)2.70426321
69Diaphragmatic weakness (HP:0009113)2.70137839
70Myotonia (HP:0002486)2.68933990
71Abnormality of the femoral head (HP:0003368)2.66180833
72Alacrima (HP:0000522)2.63045286
73Hypophosphatemic rickets (HP:0004912)2.62741083
74Abnormality of incisor morphology (HP:0011063)2.60362771
75Sleep apnea (HP:0010535)2.59073748
76Stridor (HP:0010307)2.58884851
77Potter facies (HP:0002009)2.57545387
78Facial shape deformation (HP:0011334)2.57545387
79Abnormality of the nasal septum (HP:0000419)2.55452862
80Thrombophlebitis (HP:0004418)2.54764678
81Focal seizures (HP:0007359)2.52646171
82Shawl scrotum (HP:0000049)2.51429180
83Progressive cerebellar ataxia (HP:0002073)2.49466422
84Delayed epiphyseal ossification (HP:0002663)2.45719665
85Increased serum pyruvate (HP:0003542)2.43625693
86Abnormal hand bone ossification (HP:0010660)2.42784782
87Neurofibrillary tangles (HP:0002185)2.42480378
88Abnormality of glycolysis (HP:0004366)2.42255528
89Broad palm (HP:0001169)2.41775509
90Abnormal ossification of hand bones (HP:0005921)2.41517662
91Hyperglycinemia (HP:0002154)2.40800958
92Hypoalphalipoproteinemia (HP:0003233)2.35455717
93Steatorrhea (HP:0002570)2.34904896
94Enlarged kidneys (HP:0000105)2.31598583
95Flat acetabular roof (HP:0003180)2.30951857
96Deep venous thrombosis (HP:0002625)2.29031356
97Dialeptic seizures (HP:0011146)2.28289037
98Abnormal tarsal ossification (HP:0008369)2.27578320
99Abnormality of the intrinsic pathway (HP:0010989)2.26706473
100Conjugated hyperbilirubinemia (HP:0002908)2.25731827
101Cardiovascular calcification (HP:0011915)2.24928773
102Truncal obesity (HP:0001956)2.24589951
103Limited hip movement (HP:0008800)2.24353890
104Hypoglycemic coma (HP:0001325)2.23045255
105Abnormality of the distal phalanx of the thumb (HP:0009617)2.21837596
106Termporal pattern (HP:0011008)2.20731647
107Insidious onset (HP:0003587)2.20731647
108Postural tremor (HP:0002174)2.20107735
109Neonatal onset (HP:0003623)2.19950116
110Amyloidosis (HP:0011034)2.19089579
111Transposition of the great arteries (HP:0001669)2.18647163
112Abnormal connection of the cardiac segments (HP:0011545)2.18647163
113Abnormal ventriculo-arterial connection (HP:0011563)2.18647163
114Abnormality of pain sensation (HP:0010832)2.15927621
115Impaired pain sensation (HP:0007328)2.15927621
116Retinal atrophy (HP:0001105)2.15212341
117Hypertriglyceridemia (HP:0002155)2.13968713
118Hypothermia (HP:0002045)2.13361472
119Hepatocellular carcinoma (HP:0001402)2.10034382
120Wide anterior fontanel (HP:0000260)2.09804699
121Abnormality of monocarboxylic acid metabolism (HP:0010996)2.08702511
122Bifid scrotum (HP:0000048)2.07669389
123Abnormal neuron morphology (HP:0012757)2.06608674
124Abnormality of the motor neurons (HP:0002450)2.06608674
125Abnormal delivery (HP:0001787)2.03728834
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03461013
127Hoarse voice (HP:0001609)2.02062118
128Abnormality of the lumbar spine (HP:0100712)2.00914610
129Cerebral inclusion bodies (HP:0100314)2.00655945
130Progressive sensorineural hearing impairment (HP:0000408)1.99080618
131Torticollis (HP:0000473)1.97529645
132Widely patent fontanelles and sutures (HP:0004492)1.97520421
133Pigmentary retinal degeneration (HP:0001146)1.96656960
134Hyperlipoproteinemia (HP:0010980)1.96356537
135Myocardial infarction (HP:0001658)1.93933561
136Poikilocytosis (HP:0004447)1.93360529
137Decreased lacrimation (HP:0000633)1.92198302
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90248390
139Bradycardia (HP:0001662)1.87520469
140Nephritis (HP:0000123)1.85192186
141Osteomalacia (HP:0002749)1.85085289
142Gonadal dysgenesis (HP:0000133)1.83306600
143Athetosis (HP:0002305)1.82612290
144Bicornuate uterus (HP:0000813)1.82128939
145Mitral stenosis (HP:0001718)1.81790816
146Impulsivity (HP:0100710)1.81348172
147Periauricular skin pits (HP:0100277)1.81088613
148Preauricular pit (HP:0004467)1.81088613
149Generalized tonic-clonic seizures (HP:0002069)1.80886670
150Abnormality of the pancreatic islet cells (HP:0006476)1.80772945
151Abnormality of endocrine pancreas physiology (HP:0012093)1.80772945
152Palpitations (HP:0001962)1.79708763
153Rectal fistula (HP:0100590)1.78516568
154Rectovaginal fistula (HP:0000143)1.78516568
155Skin nodule (HP:0200036)1.78343780
156Rickets (HP:0002748)1.76503600
157Focal motor seizures (HP:0011153)1.75578406
158Abnormality of glycine metabolism (HP:0010895)1.75170014
159Abnormality of serine family amino acid metabolism (HP:0010894)1.75170014
160Absent eyebrow (HP:0002223)1.74340377
161Coronal craniosynostosis (HP:0004440)1.73933888
162Overfolded helix (HP:0000396)1.73625907
163Spastic gait (HP:0002064)1.73076218
164Abnormality of the corticospinal tract (HP:0002492)1.72622386
165Hypoglycemic seizures (HP:0002173)1.71602703
166Flat capital femoral epiphysis (HP:0003370)1.70345950
167Ileus (HP:0002595)1.70023273
168Craniofacial dystonia (HP:0012179)1.69977839
169Abnormality of the wing of the ilium (HP:0011867)1.69768189
170Abnormality of the fibula (HP:0002991)1.69524251
171Abnormality of the fingertips (HP:0001211)1.69033196
172Broad thumb (HP:0011304)1.68660580
173Abnormal foot bone ossification (HP:0010675)1.68646380
174Annular pancreas (HP:0001734)1.67905753
175Abnormality of the alveolar ridges (HP:0006477)1.67003123
176Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66634162
177Degeneration of the lateral corticospinal tracts (HP:0002314)1.66634162
178Limb-girdle muscle weakness (HP:0003325)1.66236346
179Embryonal neoplasm (HP:0002898)1.66083713
180Respiratory difficulties (HP:0002880)1.65738455
181Abnormality of the shoulder girdle musculature (HP:0001435)1.65631012
182Anal stenosis (HP:0002025)1.65326188
183Wide nose (HP:0000445)1.65005179
184Neonatal death (HP:0003811)1.64819082
185Abnormal cartilage morphology (HP:0002763)1.64686377
186Abnormality of the Achilles tendon (HP:0005109)1.63851624
187Focal dystonia (HP:0004373)1.63571017
188Chronic hepatic failure (HP:0100626)1.63305743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.40482154
2ICK4.02620659
3ARAF3.89007662
4FGFR33.83525878
5CDK123.75032058
6MAP3K93.51419300
7LATS13.19598858
8LMTK23.13207769
9LIMK13.05914211
10PDK22.83299936
11CSNK1G32.80167130
12CSNK1A1L2.71991446
13TYRO32.63558584
14NTRK32.57357275
15GRK52.37788544
16DAPK22.36954206
17RIPK12.33604680
18EEF2K2.32601567
19EPHB12.29419910
20STK392.24368526
21KSR22.18974200
22CSNK1G22.12571536
23RET2.08132741
24CSNK1G12.04796001
25FGFR22.03150617
26PNCK1.97053966
27STK38L1.91852027
28LATS21.89996619
29FGFR11.86966672
30PDGFRA1.86741745
31MAP3K21.84732232
32NME11.76432070
33PIM21.74030172
34MAPK111.68063198
35AKT31.66144340
36MAP2K31.63886610
37MARK11.55316803
38CDK71.50301828
39OXSR11.47412457
40MAP3K131.46005266
41ERN11.45029097
42PIK3CA1.40020579
43PTK2B1.37697472
44TRPM71.37630451
45PDPK11.37472577
46NTRK11.37308527
47CDK51.32161141
48CAMK41.24185912
49EIF2AK11.23896120
50SIK21.20990689
51STK241.17574844
52PHKG21.13886271
53PHKG11.13886271
54MATK1.13858563
55UHMK11.13365591
56MAP2K61.11298378
57TAOK11.09210757
58PRKAA21.09076944
59WNK41.08370177
60CAMKK11.08063184
61PRKG21.07251376
62PINK11.06315504
63EPHA31.03810500
64CDK191.02737654
65PKN21.02165846
66PDK11.01081311
67EPHA40.99435592
68ALK0.99295360
69EPHA20.98778548
70TAOK20.97103434
71ILK0.94620764
72CAMKK20.93438561
73IRAK30.93195955
74MAP3K110.89562506
75ROCK20.89046827
76MAP3K10.88182608
77MAP3K120.85907209
78BRSK10.84966717
79BCR0.84514833
80STK380.82773872
81MAPK130.82591903
82BRD40.82426159
83BMPR1B0.80557083
84CDK140.80405948
85ABL20.80153999
86NME20.79663625
87DDR20.78081051
88NEK90.77621294
89RPS6KB10.76843058
90BRAF0.75559243
91CAMK2B0.75371857
92EPHB20.73737250
93MAPKAPK50.72603557
94RAF10.70935393
95CDK150.69375958
96PKN10.68767871
97DAPK30.67930301
98PRKCZ0.67105579
99RPS6KB20.66523272
100PRKAA10.66108560
101CSNK1E0.66087793
102CDK180.65815071
103CCNB10.65644165
104PRKCH0.64960402
105MAP3K70.64207093
106MINK10.62836738
107CDC42BPA0.59703863
108TGFBR10.59004443
109CASK0.58708655
110CDK11A0.58615062
111SIK10.58247939
112PRKACG0.57814889
113BLK0.57335767
114NEK10.56951238
115BRSK20.56612073
116FGR0.56063100
117TRIB30.55336086
118MTOR0.54170257
119CDK40.54107865
120SGK30.53250489
121DYRK1B0.52726483
122WNK10.52185962
123ERBB20.49834788
124SGK4940.49466621
125SGK2230.49466621
126TESK10.48848532
127SGK10.48386274
128MAP3K30.48113696
129CSF1R0.47862385
130PBK0.46622413
131FYN0.44908197
132CAMK1D0.44879178
133NEK20.44313844
134NTRK20.44127643
135TESK20.43965417
136MAPKAPK30.42040084
137STK160.41752822
138PRKACA0.41483677
139CAMK2G0.40641811
140CSNK1D0.40615415
141PTK20.40440892
142MAP2K10.39675144
143CSNK2A10.38867992
144MAP2K20.37773072
145LRRK20.37634823
146PAK30.37175528
147MAP2K40.36199971
148AKT20.35512235
149TLK10.34842387
150PAK60.34380101
151RPS6KA20.33801803
152CDK80.33505255
153SMG10.33402361
154CSNK2A20.32861500
155CAMK2A0.31599890
156ERBB40.31311084
157KDR0.28288260
158MAP3K50.25549112
159CDK20.23351073
160CDK60.22416029
161CDK10.22271923
162SRC0.20364164
163CAMK1G0.19896257
164CSNK1A10.18942972

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.80449127
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.25859067
3Vitamin digestion and absorption_Homo sapiens_hsa049772.70881256
4Oxidative phosphorylation_Homo sapiens_hsa001902.69602864
5Sulfur metabolism_Homo sapiens_hsa009202.62111334
6Nitrogen metabolism_Homo sapiens_hsa009102.60548188
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50148280
8Rheumatoid arthritis_Homo sapiens_hsa053232.46813193
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.36413795
10Synaptic vesicle cycle_Homo sapiens_hsa047212.24406154
11Steroid biosynthesis_Homo sapiens_hsa001002.14870980
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09149040
13Collecting duct acid secretion_Homo sapiens_hsa049662.04571437
14Parkinsons disease_Homo sapiens_hsa050122.02636242
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01570332
16Vibrio cholerae infection_Homo sapiens_hsa051101.98338818
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.97093271
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93055258
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.89446594
20Butanoate metabolism_Homo sapiens_hsa006501.87782499
21Alzheimers disease_Homo sapiens_hsa050101.86959425
22Fatty acid elongation_Homo sapiens_hsa000621.86411836
23Fatty acid biosynthesis_Homo sapiens_hsa000611.84545357
24Other glycan degradation_Homo sapiens_hsa005111.81208040
25Cardiac muscle contraction_Homo sapiens_hsa042601.74608778
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73211157
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70952867
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63060433
29Vitamin B6 metabolism_Homo sapiens_hsa007501.60305109
30Ribosome_Homo sapiens_hsa030101.51143709
31Folate biosynthesis_Homo sapiens_hsa007901.49371745
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.46347952
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46054401
34* Hematopoietic cell lineage_Homo sapiens_hsa046401.43501572
35Biosynthesis of amino acids_Homo sapiens_hsa012301.40528795
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.40141902
37GABAergic synapse_Homo sapiens_hsa047271.37137994
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37123608
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36986241
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33402168
41Huntingtons disease_Homo sapiens_hsa050161.30074641
42Staphylococcus aureus infection_Homo sapiens_hsa051501.29420167
43Taste transduction_Homo sapiens_hsa047421.27485802
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25701128
45Glutamatergic synapse_Homo sapiens_hsa047241.24832598
46Chemical carcinogenesis_Homo sapiens_hsa052041.24557932
47Phenylalanine metabolism_Homo sapiens_hsa003601.23268374
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23030181
49Bile secretion_Homo sapiens_hsa049761.21016530
50Fatty acid metabolism_Homo sapiens_hsa012121.20131243
51Long-term potentiation_Homo sapiens_hsa047201.18039490
52Pyruvate metabolism_Homo sapiens_hsa006201.15310781
53Sulfur relay system_Homo sapiens_hsa041221.15113182
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.14812750
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12271896
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11352900
57Nicotine addiction_Homo sapiens_hsa050331.10855157
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10054235
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09859850
60N-Glycan biosynthesis_Homo sapiens_hsa005101.08818952
61Circadian entrainment_Homo sapiens_hsa047131.08352268
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08321122
63Melanogenesis_Homo sapiens_hsa049161.06188531
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05485003
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04702498
66Retinol metabolism_Homo sapiens_hsa008301.03438736
67Renal cell carcinoma_Homo sapiens_hsa052111.03402593
68Morphine addiction_Homo sapiens_hsa050321.00616720
69Dorso-ventral axis formation_Homo sapiens_hsa043201.00142254
70Olfactory transduction_Homo sapiens_hsa047400.97949978
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.95545113
72Galactose metabolism_Homo sapiens_hsa000520.94627337
73Renin-angiotensin system_Homo sapiens_hsa046140.92447132
74Axon guidance_Homo sapiens_hsa043600.92223955
75Arginine biosynthesis_Homo sapiens_hsa002200.90915026
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90177175
77Cholinergic synapse_Homo sapiens_hsa047250.89657249
78Histidine metabolism_Homo sapiens_hsa003400.87340553
79Prion diseases_Homo sapiens_hsa050200.87251876
80Insulin secretion_Homo sapiens_hsa049110.86295277
81Fatty acid degradation_Homo sapiens_hsa000710.85734881
82Peroxisome_Homo sapiens_hsa041460.84875004
83Salivary secretion_Homo sapiens_hsa049700.82828040
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80998285
85Complement and coagulation cascades_Homo sapiens_hsa046100.79936644
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79029994
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78461252
88Lysine degradation_Homo sapiens_hsa003100.76700426
89Glycerolipid metabolism_Homo sapiens_hsa005610.75716705
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74690500
91Cocaine addiction_Homo sapiens_hsa050300.74606560
92Arginine and proline metabolism_Homo sapiens_hsa003300.74082183
93beta-Alanine metabolism_Homo sapiens_hsa004100.73576215
94ECM-receptor interaction_Homo sapiens_hsa045120.73194240
95One carbon pool by folate_Homo sapiens_hsa006700.72538652
96Protein digestion and absorption_Homo sapiens_hsa049740.72105123
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72078475
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71745951
99Glutathione metabolism_Homo sapiens_hsa004800.68608057
100Serotonergic synapse_Homo sapiens_hsa047260.67598394
101Tyrosine metabolism_Homo sapiens_hsa003500.67117084
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64554087
103PPAR signaling pathway_Homo sapiens_hsa033200.63769185
104Sphingolipid metabolism_Homo sapiens_hsa006000.63476352
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60376788
106Dopaminergic synapse_Homo sapiens_hsa047280.57504213
107Gastric acid secretion_Homo sapiens_hsa049710.54029456
108Fructose and mannose metabolism_Homo sapiens_hsa000510.53384608
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52738325
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.51583768
111ABC transporters_Homo sapiens_hsa020100.49736602
112Thyroid hormone synthesis_Homo sapiens_hsa049180.49637664
113cAMP signaling pathway_Homo sapiens_hsa040240.47614790
114Propanoate metabolism_Homo sapiens_hsa006400.46298136
115Phagosome_Homo sapiens_hsa041450.44698569
116Glucagon signaling pathway_Homo sapiens_hsa049220.44537701
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44112021
118Mineral absorption_Homo sapiens_hsa049780.43796042
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.41205082
120Caffeine metabolism_Homo sapiens_hsa002320.40149706
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39804805
122Amphetamine addiction_Homo sapiens_hsa050310.38777693
123Pentose phosphate pathway_Homo sapiens_hsa000300.38360071
124Starch and sucrose metabolism_Homo sapiens_hsa005000.36716353
125Endocytosis_Homo sapiens_hsa041440.36260530
126Metabolic pathways_Homo sapiens_hsa011000.35181840
127Long-term depression_Homo sapiens_hsa047300.34895939
128Insulin resistance_Homo sapiens_hsa049310.34622983
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34509138
130Pertussis_Homo sapiens_hsa051330.34449284
131Dilated cardiomyopathy_Homo sapiens_hsa054140.33558816
132Estrogen signaling pathway_Homo sapiens_hsa049150.33058425
133TGF-beta signaling pathway_Homo sapiens_hsa043500.32015724
134* Jak-STAT signaling pathway_Homo sapiens_hsa046300.31837437
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31284479
136Oxytocin signaling pathway_Homo sapiens_hsa049210.29536061
137Carbon metabolism_Homo sapiens_hsa012000.28453604
138Tryptophan metabolism_Homo sapiens_hsa003800.27761623
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26951974
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.26896908
141Pancreatic secretion_Homo sapiens_hsa049720.26221183
142Ovarian steroidogenesis_Homo sapiens_hsa049130.26124090
143African trypanosomiasis_Homo sapiens_hsa051430.23652409
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22681186
145AMPK signaling pathway_Homo sapiens_hsa041520.20335044
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.19891084
147Wnt signaling pathway_Homo sapiens_hsa043100.18976838
148Basal cell carcinoma_Homo sapiens_hsa052170.18850090
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18542017
150Bladder cancer_Homo sapiens_hsa052190.18529945
151Hippo signaling pathway_Homo sapiens_hsa043900.18028460
152Insulin signaling pathway_Homo sapiens_hsa049100.17554432
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16877686
154Non-small cell lung cancer_Homo sapiens_hsa052230.15974111

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