EPS15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.93643825
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93607353
3synaptic vesicle exocytosis (GO:0016079)4.91333957
4glutamate secretion (GO:0014047)4.70931830
5vocalization behavior (GO:0071625)4.68945482
6regulation of synaptic vesicle exocytosis (GO:2000300)4.64751572
7locomotory exploration behavior (GO:0035641)4.61224317
8neuronal action potential propagation (GO:0019227)4.59745237
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55895918
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52681346
11neuron cell-cell adhesion (GO:0007158)4.42502488
12negative regulation of synaptic transmission, GABAergic (GO:0032229)4.23347901
13regulation of glutamate receptor signaling pathway (GO:1900449)4.17323639
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.08339142
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.07418028
16regulation of synaptic vesicle transport (GO:1902803)4.04378493
17neurotransmitter-gated ion channel clustering (GO:0072578)4.03501060
18presynaptic membrane assembly (GO:0097105)4.00756410
19protein localization to synapse (GO:0035418)3.99841593
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98144437
21neurotransmitter secretion (GO:0007269)3.78715965
22gamma-aminobutyric acid transport (GO:0015812)3.78330797
23gamma-aminobutyric acid signaling pathway (GO:0007214)3.77917697
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.77140219
25presynaptic membrane organization (GO:0097090)3.74988009
26glutamate receptor signaling pathway (GO:0007215)3.74159256
27neuron-neuron synaptic transmission (GO:0007270)3.71934775
28synaptic transmission, glutamatergic (GO:0035249)3.67499328
29exploration behavior (GO:0035640)3.62872821
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61905744
31regulation of neuronal synaptic plasticity (GO:0048168)3.58364758
32L-amino acid import (GO:0043092)3.57692993
33phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.57052498
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.55242851
35cellular potassium ion homeostasis (GO:0030007)3.54874566
36protein targeting to Golgi (GO:0000042)3.46731466
37regulation of ARF protein signal transduction (GO:0032012)3.42435129
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.41941692
39long-term synaptic potentiation (GO:0060291)3.41122881
40establishment of protein localization to Golgi (GO:0072600)3.40976257
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39592165
42regulation of cAMP-dependent protein kinase activity (GO:2000479)3.33212750
43retrograde transport, vesicle recycling within Golgi (GO:0000301)3.31991939
44transmission of nerve impulse (GO:0019226)3.31267282
45cerebellar granule cell differentiation (GO:0021707)3.30473222
46detection of calcium ion (GO:0005513)3.26542000
47regulation of synapse structural plasticity (GO:0051823)3.25212827
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.24279263
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21052906
50negative regulation of neurotransmitter transport (GO:0051589)3.20780104
51regulation of postsynaptic membrane potential (GO:0060078)3.20762415
52neurotransmitter transport (GO:0006836)3.19095715
53synaptic vesicle endocytosis (GO:0048488)3.18522498
54proline transport (GO:0015824)3.17099771
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.17004298
56layer formation in cerebral cortex (GO:0021819)3.15557480
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15470418
58regulation of synaptic plasticity (GO:0048167)3.15466254
59relaxation of cardiac muscle (GO:0055119)3.15262242
60long-term memory (GO:0007616)3.14830208
61postsynaptic membrane organization (GO:0001941)3.13305072
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.09949551
63regulation of neurotransmitter secretion (GO:0046928)3.07350237
64positive regulation of membrane potential (GO:0045838)3.06187485
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05615111
66neuron recognition (GO:0008038)3.04630100
67positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.03787664
68central nervous system myelination (GO:0022010)3.03406154
69axon ensheathment in central nervous system (GO:0032291)3.03406154
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02073238
71regulation of voltage-gated calcium channel activity (GO:1901385)2.99926699
72regulation of clathrin-mediated endocytosis (GO:2000369)2.99874720
73cerebellar Purkinje cell differentiation (GO:0021702)2.98797003
74negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98024033
75regulation of protein glycosylation (GO:0060049)2.97080067
76sodium ion export (GO:0071436)2.96806289
77cellular response to ethanol (GO:0071361)2.96102097
78regulation of neurotransmitter levels (GO:0001505)2.94971347
79amino acid import (GO:0043090)2.93085306
80negative regulation of dendrite morphogenesis (GO:0050774)2.92964410
81regulation of synaptic transmission, GABAergic (GO:0032228)2.92221859
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91965141
83cell communication by electrical coupling (GO:0010644)2.91684356
84regulation of dendritic spine morphogenesis (GO:0061001)2.90053651
85positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88888277
86mechanosensory behavior (GO:0007638)2.88812551
87adult walking behavior (GO:0007628)2.88417117
88vesicle transport along microtubule (GO:0047496)2.88372232
89membrane depolarization (GO:0051899)2.88089831
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.86794721
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86760658
92regulation of neurotransmitter transport (GO:0051588)2.86087920
93synapse assembly (GO:0007416)2.85458883
94auditory behavior (GO:0031223)2.85376692
95response to histamine (GO:0034776)2.85354471
96activation of protein kinase A activity (GO:0034199)2.84290396
97membrane depolarization during action potential (GO:0086010)2.83995835
98potassium ion import (GO:0010107)2.82605443
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81816687
100positive regulation of synaptic transmission (GO:0050806)2.80161442
101learning (GO:0007612)2.80026930
102regulation of vesicle fusion (GO:0031338)2.78866575
103acidic amino acid transport (GO:0015800)2.77160150
104response to auditory stimulus (GO:0010996)2.76897679
105dendrite morphogenesis (GO:0048813)2.76645974
106innervation (GO:0060384)2.76171611
107regulation of synaptic transmission (GO:0050804)2.74942184
108negative regulation of neurotransmitter secretion (GO:0046929)2.74522016
109nerve growth factor signaling pathway (GO:0038180)2.74366419
110neuromuscular process controlling balance (GO:0050885)2.74039877
111dendritic spine morphogenesis (GO:0060997)2.73170997
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72383771
113positive regulation of Rap GTPase activity (GO:0032854)2.71926805
114* Golgi to endosome transport (GO:0006895)2.70872587
115detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.69851752
116detection of temperature stimulus involved in sensory perception (GO:0050961)2.69851752
117positive regulation of synaptic transmission, GABAergic (GO:0032230)2.69197456
118potassium ion homeostasis (GO:0055075)2.68971092
119behavioral defense response (GO:0002209)2.68198464
120behavioral fear response (GO:0001662)2.68198464
121neurotransmitter uptake (GO:0001504)2.68161647
122regulation of dendritic spine development (GO:0060998)2.67664334
123synaptic transmission (GO:0007268)2.67354076
124regulation of beta-amyloid formation (GO:1902003)2.67081416
125organelle transport along microtubule (GO:0072384)2.65993545
126regulation of Rap GTPase activity (GO:0032317)2.65883474
127establishment of nucleus localization (GO:0040023)2.65296166
128positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.61565858
129nucleus localization (GO:0051647)2.53305940
130B cell receptor signaling pathway (GO:0050853)2.52744080
131relaxation of muscle (GO:0090075)2.51864890
132* clathrin coat assembly (GO:0048268)2.51452716
133regulation of B cell receptor signaling pathway (GO:0050855)2.47126191
134regulation of cell communication by electrical coupling (GO:0010649)2.44076899
135cellular sodium ion homeostasis (GO:0006883)2.41055007
136interkinetic nuclear migration (GO:0022027)2.40929329
137regulation of calcium ion transmembrane transporter activity (GO:1901019)2.40048054
138regulation of calcium ion transmembrane transport (GO:1903169)2.40048054
139peptidyl-threonine phosphorylation (GO:0018107)2.39473363
140lipid translocation (GO:0034204)2.38770125
141phospholipid translocation (GO:0045332)2.38770125
142positive regulation of neurotransmitter secretion (GO:0001956)2.38259418
143neuronal ion channel clustering (GO:0045161)2.37325098
144cell communication involved in cardiac conduction (GO:0086065)2.36312422
145positive regulation of cardiac muscle hypertrophy (GO:0010613)2.34778393
146positive regulation of muscle hypertrophy (GO:0014742)2.34778393
147regulation of Rac protein signal transduction (GO:0035020)2.32362803
148regulation of relaxation of muscle (GO:1901077)2.32098692
149positive regulation of neurotransmitter transport (GO:0051590)2.28054786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48266123
2GBX2_23144817_ChIP-Seq_PC3_Human3.90740379
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88706882
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83242581
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63354351
6GATA1_22025678_ChIP-Seq_K562_Human2.59970436
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59922432
8TAF15_26573619_Chip-Seq_HEK293_Human2.42033415
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39496907
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32940332
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32940332
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29663774
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26978292
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23977173
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22921224
16REST_21632747_ChIP-Seq_MESCs_Mouse2.20489573
17AR_21572438_ChIP-Seq_LNCaP_Human2.11382217
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11185005
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04425498
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03107517
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.02746167
22DROSHA_22980978_ChIP-Seq_HELA_Human2.00568186
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.97846590
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96058420
25EZH2_27304074_Chip-Seq_ESCs_Mouse1.95936372
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.91528270
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90601496
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89903600
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.88561381
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87488184
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87327826
32SMAD4_21799915_ChIP-Seq_A2780_Human1.82330431
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.79398395
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.78333876
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76729099
36* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75595738
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71802000
38P300_19829295_ChIP-Seq_ESCs_Human1.70753024
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.66453643
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63720321
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62369477
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.60909095
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60626176
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59917766
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58330862
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57445270
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56169897
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51250751
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50971767
50* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49246158
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47762493
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45671103
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.44758618
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43528000
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.43162687
56AR_25329375_ChIP-Seq_VCAP_Human1.42290730
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41961825
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41324762
59* STAT3_23295773_ChIP-Seq_U87_Human1.39999433
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39985086
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36559690
62* SOX2_21211035_ChIP-Seq_LN229_Gbm1.35688569
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35347593
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.33198812
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.33067585
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32907346
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.32691874
68ER_23166858_ChIP-Seq_MCF-7_Human1.32409129
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31450896
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.30430566
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29166185
72P53_22387025_ChIP-Seq_ESCs_Mouse1.28911497
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27930695
74AHR_22903824_ChIP-Seq_MCF-7_Human1.27407347
75RUNX_20019798_ChIP-Seq_JUKART_Human1.26968768
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.26549481
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.23567675
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23365701
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.22476497
80* TCF4_23295773_ChIP-Seq_U87_Human1.22082228
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21880915
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21409784
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19566612
84IGF1R_20145208_ChIP-Seq_DFB_Human1.19480660
85FUS_26573619_Chip-Seq_HEK293_Human1.18944531
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18711376
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18456635
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17280537
89TP53_16413492_ChIP-PET_HCT116_Human1.16829573
90* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15877128
91* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14782414
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14210279
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13510516
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13089324
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.11917669
96IRF8_22096565_ChIP-ChIP_GC-B_Human1.11857114
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11777064
98CBP_20019798_ChIP-Seq_JUKART_Human1.11039014
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11039014
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.08995992
101RXR_22108803_ChIP-Seq_LS180_Human1.08727944
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08605905
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08426526
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08426526
105RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08274745
106VDR_22108803_ChIP-Seq_LS180_Human1.08097603
107* AR_19668381_ChIP-Seq_PC3_Human1.08034275
108P300_18555785_Chip-Seq_ESCs_Mouse1.07162686
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06958353
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.06723625
111* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06641199
112RNF2_27304074_Chip-Seq_NSC_Mouse1.06528449
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.06369072
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05645097
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05621642
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05537882
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05498588
118* RUNX2_22187159_ChIP-Seq_PCA_Human1.05400968
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05047929
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04897230
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04745442
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.04357494
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03649339
124EWS_26573619_Chip-Seq_HEK293_Human1.03428993
125* NANOG_18555785_Chip-Seq_ESCs_Mouse1.03017146
126TP53_18474530_ChIP-ChIP_U2OS_Human1.02811201
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.02553972
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.02093817
129* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99576390
130* JUN_21703547_ChIP-Seq_K562_Human0.98713607
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.97473673
132RING1B_27294783_Chip-Seq_ESCs_Mouse0.97460279
133ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95323181
134KDM2B_26808549_Chip-Seq_REH_Human0.95120778
135ZNF274_21170338_ChIP-Seq_K562_Hela0.94558795
136BCAT_22108803_ChIP-Seq_LS180_Human0.93943762
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.93497482
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.93034114
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92141342
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.91490818
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90055145
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89689298
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89689298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78585243
2MP0003880_abnormal_central_pattern4.77090314
3MP0004270_analgesia4.02457875
4MP0003635_abnormal_synaptic_transmissio3.90788918
5MP0009046_muscle_twitch3.51795318
6MP0009745_abnormal_behavioral_response3.36441769
7MP0002064_seizures3.30828079
8MP0001968_abnormal_touch/_nociception3.19900059
9MP0002063_abnormal_learning/memory/cond3.12612061
10MP0002735_abnormal_chemical_nociception2.88766475
11MP0002272_abnormal_nervous_system2.87455168
12MP0002572_abnormal_emotion/affect_behav2.71049049
13MP0002734_abnormal_mechanical_nocicepti2.70117546
14MP0002736_abnormal_nociception_after2.63572454
15MP0001486_abnormal_startle_reflex2.61400927
16MP0008057_abnormal_DNA_replication2.19448561
17MP0003329_amyloid_beta_deposits2.17073500
18MP0002067_abnormal_sensory_capabilities2.15178753
19MP0001501_abnormal_sleep_pattern2.12723829
20MP0001440_abnormal_grooming_behavior2.11254029
21MP0009780_abnormal_chondrocyte_physiolo2.07657588
22MP0005423_abnormal_somatic_nervous2.04960392
23MP0002733_abnormal_thermal_nociception2.04229877
24MP0001970_abnormal_pain_threshold2.03804383
25MP0008569_lethality_at_weaning1.98867108
26MP0000920_abnormal_myelination1.97159692
27MP0002822_catalepsy1.97150866
28MP0003690_abnormal_glial_cell1.81562879
29MP0000778_abnormal_nervous_system1.78349654
30MP0004885_abnormal_endolymph1.77821606
31MP0002009_preneoplasia1.74970166
32MP0004858_abnormal_nervous_system1.74497009
33MP0004924_abnormal_behavior1.72951324
34MP0005386_behavior/neurological_phenoty1.72951324
35MP0002184_abnormal_innervation1.63743059
36MP0004811_abnormal_neuron_physiology1.62989879
37MP0006276_abnormal_autonomic_nervous1.60325258
38MP0003633_abnormal_nervous_system1.59774596
39MP0003879_abnormal_hair_cell1.58875555
40MP0004142_abnormal_muscle_tone1.57345237
41MP0005174_abnormal_tail_pigmentation1.52733876
42MP0003787_abnormal_imprinting1.52357402
43MP0004084_abnormal_cardiac_muscle1.50886186
44MP0005646_abnormal_pituitary_gland1.49456900
45MP0000955_abnormal_spinal_cord1.48701693
46MP0001905_abnormal_dopamine_level1.46578915
47MP0000015_abnormal_ear_pigmentation1.44752458
48MP0002557_abnormal_social/conspecific_i1.43935192
49MP0002066_abnormal_motor_capabilities/c1.43786852
50MP0003631_nervous_system_phenotype1.43528986
51MP0002882_abnormal_neuron_morphology1.40231856
52MP0003303_peritoneal_inflammation1.39307741
53MP0001984_abnormal_olfaction1.37740574
54MP0003172_abnormal_lysosome_physiology1.35977156
55MP0001529_abnormal_vocalization1.34489447
56MP0000604_amyloidosis1.34342329
57MP0010234_abnormal_vibrissa_follicle1.33280316
58MP0003634_abnormal_glial_cell1.30047448
59MP0001986_abnormal_taste_sensitivity1.22161103
60MP0004742_abnormal_vestibular_system1.20811354
61MP0002229_neurodegeneration1.20070796
62MP0003632_abnormal_nervous_system1.18482228
63MP0004147_increased_porphyrin_level1.16628365
64MP0002638_abnormal_pupillary_reflex1.15375277
65MP0002909_abnormal_adrenal_gland1.14760285
66MP0005171_absent_coat_pigmentation1.10410658
67MP0001502_abnormal_circadian_rhythm1.08419965
68MP0005645_abnormal_hypothalamus_physiol1.02363003
69MP0002332_abnormal_exercise_endurance0.98762077
70MP0001963_abnormal_hearing_physiology0.97840989
71MP0008874_decreased_physiological_sensi0.97584732
72MP0002166_altered_tumor_susceptibility0.97020557
73MP0000751_myopathy0.95636224
74MP0010352_gastrointestinal_tract_polyps0.95248936
75MP0002152_abnormal_brain_morphology0.95095890
76MP0005410_abnormal_fertilization0.94287127
77MP0003183_abnormal_peptide_metabolism0.91395714
78MP0010678_abnormal_skin_adnexa0.90502168
79MP0002876_abnormal_thyroid_physiology0.90076478
80MP0001188_hyperpigmentation0.88597003
81MP0001485_abnormal_pinna_reflex0.86681162
82MP0005623_abnormal_meninges_morphology0.86465737
83MP0005187_abnormal_penis_morphology0.84636055
84MP0001851_eye_inflammation0.83697709
85MP0001177_atelectasis0.83163728
86MP0001348_abnormal_lacrimal_gland0.82777060
87MP0000569_abnormal_digit_pigmentation0.82266414
88MP0003075_altered_response_to0.81387232
89MP0008872_abnormal_physiological_respon0.80311662
90MP0004484_altered_response_of0.80239455
91MP0003724_increased_susceptibility_to0.79823387
92MP0004145_abnormal_muscle_electrophysio0.78027401
93MP0003763_abnormal_thymus_physiology0.77079120
94MP0001835_abnormal_antigen_presentation0.76281077
95MP0002069_abnormal_eating/drinking_beha0.75893491
96MP0005551_abnormal_eye_electrophysiolog0.73204408
97MP0005620_abnormal_muscle_contractility0.71710971
98MP0000013_abnormal_adipose_tissue0.70992331
99MP0005075_abnormal_melanosome_morpholog0.70797611
100MP0002090_abnormal_vision0.70726769
101MP0005535_abnormal_body_temperature0.69602882
102MP0002752_abnormal_somatic_nervous0.68495762
103MP0008877_abnormal_DNA_methylation0.67795348
104MP0004085_abnormal_heartbeat0.67470228
105MP0001299_abnormal_eye_distance/0.66827982
106MP0003091_abnormal_cell_migration0.66527958
107MP0003300_gastrointestinal_ulcer0.65596774
108MP0004510_myositis0.64544005
109MP0000465_gastrointestinal_hemorrhage0.63901226
110MP0002095_abnormal_skin_pigmentation0.63477953
111MP0003122_maternal_imprinting0.63378746
112MP0005167_abnormal_blood-brain_barrier0.63053074
113MP0005464_abnormal_platelet_physiology0.62366733
114MP0003950_abnormal_plasma_membrane0.62114689
115MP0004130_abnormal_muscle_cell0.60838505
116MP0003656_abnormal_erythrocyte_physiolo0.57496571
117MP0002837_dystrophic_cardiac_calcinosis0.57207288
118MP0001943_abnormal_respiration0.56112584
119MP0004043_abnormal_pH_regulation0.54995991
120MP0004215_abnormal_myocardial_fiber0.54746231
121MP0005310_abnormal_salivary_gland0.51849856
122MP0005409_darkened_coat_color0.49470783
123MP0004036_abnormal_muscle_relaxation0.48854555
124MP0003045_fibrosis0.48142299
125MP0010386_abnormal_urinary_bladder0.47355866
126MP0001664_abnormal_digestion0.46822035

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.42615067
2Myokymia (HP:0002411)5.60549739
3Focal seizures (HP:0007359)5.29753754
4Atonic seizures (HP:0010819)5.23638381
5Epileptic encephalopathy (HP:0200134)5.18489690
6Febrile seizures (HP:0002373)4.41931818
7Progressive cerebellar ataxia (HP:0002073)4.10754008
8Hyperventilation (HP:0002883)4.02746004
9Visual hallucinations (HP:0002367)3.97605856
10Absence seizures (HP:0002121)3.97150375
11Supranuclear gaze palsy (HP:0000605)3.87777524
12Dialeptic seizures (HP:0011146)3.84986239
13Action tremor (HP:0002345)3.84113660
14Papillary thyroid carcinoma (HP:0002895)3.82091899
15Generalized tonic-clonic seizures (HP:0002069)3.70237123
16Termporal pattern (HP:0011008)3.59735423
17Insidious onset (HP:0003587)3.59735423
18Neurofibrillary tangles (HP:0002185)3.58049498
19Broad-based gait (HP:0002136)3.43994327
20Ankle clonus (HP:0011448)3.37739383
21Gaze-evoked nystagmus (HP:0000640)3.32164577
22Abnormality of the corticospinal tract (HP:0002492)3.31864589
23Pheochromocytoma (HP:0002666)3.31773949
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.30567988
25Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.30567988
26Dysmetria (HP:0001310)3.26085913
27Cerebral inclusion bodies (HP:0100314)3.20536429
28Bundle branch block (HP:0011710)3.20160701
29Abnormality of binocular vision (HP:0011514)3.18591026
30Diplopia (HP:0000651)3.18591026
31Progressive inability to walk (HP:0002505)3.17963841
32Dysdiadochokinesis (HP:0002075)3.15315149
33Truncal ataxia (HP:0002078)3.13057688
34Impaired vibration sensation in the lower limbs (HP:0002166)3.04969137
35Scanning speech (HP:0002168)3.04511578
36Urinary bladder sphincter dysfunction (HP:0002839)3.00164774
37Neuroendocrine neoplasm (HP:0100634)2.99272852
38Abnormal eating behavior (HP:0100738)2.96341894
39Spastic gait (HP:0002064)2.92733233
40Urinary urgency (HP:0000012)2.87132779
41Postural instability (HP:0002172)2.80341649
42Depression (HP:0000716)2.77229570
43Intention tremor (HP:0002080)2.75795062
44Thyroid carcinoma (HP:0002890)2.75140149
45Menstrual irregularities (HP:0000858)2.71723852
46Poor eye contact (HP:0000817)2.69120149
47Lower limb muscle weakness (HP:0007340)2.60376279
48Abnormal hair whorl (HP:0010721)2.58568407
49Impaired social interactions (HP:0000735)2.57115278
50Abnormal social behavior (HP:0012433)2.57115278
51Fetal akinesia sequence (HP:0001989)2.54378382
52Excessive salivation (HP:0003781)2.53587341
53Drooling (HP:0002307)2.53587341
54Anxiety (HP:0000739)2.53345693
55Spontaneous hematomas (HP:0007420)2.50616129
56Akinesia (HP:0002304)2.47144831
57Megalencephaly (HP:0001355)2.43025224
58Hemiparesis (HP:0001269)2.43013168
59Mutism (HP:0002300)2.39333275
60Hyporeflexia of lower limbs (HP:0002600)2.35557866
61Hemiplegia (HP:0002301)2.32399309
62Amyotrophic lateral sclerosis (HP:0007354)2.31633130
63Amblyopia (HP:0000646)2.31527282
64Subaortic stenosis (HP:0001682)2.30715472
65Abnormality of the left ventricular outflow tract (HP:0011103)2.30715472
66Clumsiness (HP:0002312)2.30206163
67Genetic anticipation (HP:0003743)2.26757035
68Bradykinesia (HP:0002067)2.26532149
69Blue irides (HP:0000635)2.24955616
70Polyphagia (HP:0002591)2.24171286
71Sensory axonal neuropathy (HP:0003390)2.20796696
72Neuronal loss in central nervous system (HP:0002529)2.20308421
73Impaired vibratory sensation (HP:0002495)2.20086367
74Absent speech (HP:0001344)2.19077131
75Inability to walk (HP:0002540)2.18290363
76Epileptiform EEG discharges (HP:0011182)2.16450423
77Torticollis (HP:0000473)2.14291017
78Resting tremor (HP:0002322)2.12735690
79Abnormality of saccadic eye movements (HP:0000570)2.12056977
80Papilledema (HP:0001085)2.11417226
81Generalized myoclonic seizures (HP:0002123)2.11145883
82Aqueductal stenosis (HP:0002410)2.10854052
83Aplasia involving bones of the upper limbs (HP:0009823)2.10560947
84Aplasia of the phalanges of the hand (HP:0009802)2.10560947
85Aplasia involving bones of the extremities (HP:0009825)2.10560947
86Thickened helices (HP:0000391)2.10128927
87Onion bulb formation (HP:0003383)2.09520876
88Dysmetric saccades (HP:0000641)2.09363242
89Limb dystonia (HP:0002451)2.09182993
90Ventricular fibrillation (HP:0001663)2.09113355
91Syncope (HP:0001279)2.07626224
92Macroorchidism (HP:0000053)2.04281328
93Cerebral hemorrhage (HP:0001342)2.03673601
94Gait ataxia (HP:0002066)2.02649262
95Impaired smooth pursuit (HP:0007772)2.00880097
96Neoplasm of the peripheral nervous system (HP:0100007)1.99566424
97Psychosis (HP:0000709)1.99380507
98Heart block (HP:0012722)1.99209241
99EEG with generalized epileptiform discharges (HP:0011198)1.98305599
100Peripheral hypomyelination (HP:0007182)1.98265821
101Generalized hypopigmentation of hair (HP:0011358)1.95196442
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94294031
103Inappropriate behavior (HP:0000719)1.93238375
104Stereotypic behavior (HP:0000733)1.91865481
105Paraplegia (HP:0010550)1.91205109
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90300308
107Postural tremor (HP:0002174)1.89817162
108Rigidity (HP:0002063)1.89644259
109Hypsarrhythmia (HP:0002521)1.89591689
110Focal dystonia (HP:0004373)1.89559289
111Metaphyseal dysplasia (HP:0100255)1.86752025
112Abnormality of salivation (HP:0100755)1.86454468
113Status epilepticus (HP:0002133)1.85457178
114Hematochezia (HP:0002573)1.84052018
115Spastic paraplegia (HP:0001258)1.83127248
116Abnormality of ocular smooth pursuit (HP:0000617)1.82889582
117Testicular neoplasm (HP:0010788)1.81759949
118Difficulty running (HP:0009046)1.81337635
119Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80696677
120Abnormal EKG (HP:0003115)1.79990463
121Hyperkalemia (HP:0002153)1.79979660
122Spastic tetraparesis (HP:0001285)1.79913268
123Frequent falls (HP:0002359)1.79670683
124Clonus (HP:0002169)1.79388361
125Widely spaced teeth (HP:0000687)1.79231660
126Incomplete penetrance (HP:0003829)1.78527443
127Specific learning disability (HP:0001328)1.76068860
128Abnormality of the lower motor neuron (HP:0002366)1.75494587
129Atrioventricular block (HP:0001678)1.75179316
130Autoamputation (HP:0001218)1.74382824
131Truncal obesity (HP:0001956)1.74341762
132Sudden death (HP:0001699)1.73865888
133Acute myeloid leukemia (HP:0004808)1.72695567
134Disinhibition (HP:0000734)1.72477870
135Exercise-induced muscle cramps (HP:0003710)1.71812790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.82469357
2NTRK33.42794492
3EPHA43.13324315
4MAP3K42.83085812
5FRK2.78876429
6MAP3K92.77483443
7MAP2K72.71365830
8MINK12.52066750
9MARK12.31625752
10MAP3K122.22147911
11DAPK22.13155048
12OXSR12.10782374
13CDK192.10756842
14RIPK42.08466215
15PRPF4B2.08310421
16PLK21.93494246
17MAP2K41.82879586
18NTRK11.81289484
19STK391.80405143
20PAK61.71928867
21NTRK21.71157089
22FGFR31.63363880
23SGK2231.61787617
24SGK4941.61787617
25TNIK1.57020455
26TRPM71.56904853
27KSR21.56817886
28OBSCN1.51917693
29JAK11.51670669
30CDK51.44107850
31EPHA31.42984675
32GRK51.41377444
33SGK21.31336299
34ARAF1.31203014
35ERBB31.26677338
36CAMKK11.26338660
37PIK3CG1.26133530
38BMPR1B1.23573141
39DAPK11.21921225
40MAP3K131.20707414
41PRKD31.18513271
42WNK11.17343379
43PRKCG1.16038528
44MAPK131.14614156
45CAMKK21.14540398
46TAOK31.14451166
47PNCK1.14366524
48BCR1.12136553
49PTK2B1.12057981
50KSR11.11572282
51SIK31.10128283
52FES1.03544431
53NLK1.03542549
54SGK31.03115576
55CAMK2B1.01886604
56CAMK2A1.01014753
57TEC0.94907068
58ACVR1B0.93209969
59PHKG10.92917801
60PHKG20.92917801
61JAK20.92650521
62SYK0.92387712
63FGFR20.90922373
64PRKCH0.88563263
65UHMK10.87981403
66NEK90.87447421
67PKN10.87243152
68MAP3K20.85485724
69CDK140.84393408
70CDK180.83214902
71FER0.82993904
72CSNK1G20.82757549
73PRKCE0.82257907
74BMPR20.82115691
75YES10.81293381
76SCYL20.81253551
77PDK40.80451919
78PDK30.80451919
79RET0.79238602
80BRD40.78324668
81STK240.77173133
82IRAK10.77162823
83CDK150.77106354
84PDK10.75239440
85SGK10.75060412
86TYRO30.74857811
87NEK60.74791138
88ROCK20.73285073
89FGR0.71846957
90BLK0.71499776
91PDPK10.71050111
92STK110.70924462
93RPS6KB10.64541624
94SIK20.64345421
95MAP3K140.63512798
96CDK11A0.62253481
97STK38L0.61969050
98AKT30.61848381
99CAMK40.59994288
100CAMK2D0.59338000
101MAP3K60.59159761
102CAMK2G0.58729062
103MAPKAPK50.58693582
104LMTK20.57615266
105MST40.56212261
106CAMK1G0.55108257
107WNK40.54876633
108LIMK10.53505058
109STK380.53246240
110PDK20.52595761
111PRKCQ0.51588268
112CCNB10.51530536
113FYN0.50376577
114DYRK1A0.49260732
115ITK0.49034017
116MAPK70.48978578
117PIK3CA0.48924479
118MAPK120.48821716
119MARK20.48679906
120PAK30.48286621
121TNK20.47381497
122RAF10.47063316
123* MAPK100.46943716
124PRKG10.45987139
125DMPK0.45747327
126CAMK10.45142951
127PINK10.43631725
128RPS6KA30.41543134
129EEF2K0.41459669
130EPHB10.40971361
131MAP3K10.40513286
132CSNK1G30.39993773
133MAP2K10.39202461
134CSNK1A1L0.38109618
135PRKCB0.35025299
136GRK70.32789419

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41273893
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22303739
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53155827
4GABAergic synapse_Homo sapiens_hsa047272.49319123
5Glutamatergic synapse_Homo sapiens_hsa047242.38327970
6Long-term potentiation_Homo sapiens_hsa047202.35664074
7Morphine addiction_Homo sapiens_hsa050322.34806394
8Circadian entrainment_Homo sapiens_hsa047132.31026776
9Olfactory transduction_Homo sapiens_hsa047402.30030721
10Collecting duct acid secretion_Homo sapiens_hsa049662.10148307
11Salivary secretion_Homo sapiens_hsa049701.97694693
12Amphetamine addiction_Homo sapiens_hsa050311.97498131
13Dopaminergic synapse_Homo sapiens_hsa047281.87910502
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81525861
15Gastric acid secretion_Homo sapiens_hsa049711.72995628
16Circadian rhythm_Homo sapiens_hsa047101.71725808
17Long-term depression_Homo sapiens_hsa047301.68132971
18Renin secretion_Homo sapiens_hsa049241.67276207
19Cholinergic synapse_Homo sapiens_hsa047251.64147580
20Serotonergic synapse_Homo sapiens_hsa047261.58211004
21Taste transduction_Homo sapiens_hsa047421.54694242
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54332898
23Insulin secretion_Homo sapiens_hsa049111.51230011
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40886989
25Oxytocin signaling pathway_Homo sapiens_hsa049211.40147929
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38290460
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37913349
28Calcium signaling pathway_Homo sapiens_hsa040201.36830156
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.30477492
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26606371
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26382504
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22258637
33Vibrio cholerae infection_Homo sapiens_hsa051101.20821236
34B cell receptor signaling pathway_Homo sapiens_hsa046621.20508049
35Cocaine addiction_Homo sapiens_hsa050301.18345510
36Axon guidance_Homo sapiens_hsa043601.17916758
37Platelet activation_Homo sapiens_hsa046111.13002151
38cAMP signaling pathway_Homo sapiens_hsa040241.11614378
39GnRH signaling pathway_Homo sapiens_hsa049121.11586250
40Gap junction_Homo sapiens_hsa045401.11363260
41Dorso-ventral axis formation_Homo sapiens_hsa043201.08884123
42ErbB signaling pathway_Homo sapiens_hsa040121.07331345
43Nitrogen metabolism_Homo sapiens_hsa009101.07130576
44mTOR signaling pathway_Homo sapiens_hsa041501.05177921
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03950246
46Glioma_Homo sapiens_hsa052141.00498291
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95838475
48Estrogen signaling pathway_Homo sapiens_hsa049150.92898995
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89488153
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89144291
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87626013
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.85258448
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84182174
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83248242
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.82857621
56Prolactin signaling pathway_Homo sapiens_hsa049170.82542333
57Type II diabetes mellitus_Homo sapiens_hsa049300.81094298
58Rheumatoid arthritis_Homo sapiens_hsa053230.78862895
59MAPK signaling pathway_Homo sapiens_hsa040100.76325257
60T cell receptor signaling pathway_Homo sapiens_hsa046600.72290166
61Melanogenesis_Homo sapiens_hsa049160.71637356
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71612195
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71526866
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70220688
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70099185
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.69899620
67Pancreatic secretion_Homo sapiens_hsa049720.69597648
68Ras signaling pathway_Homo sapiens_hsa040140.68633152
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68252508
70* Endocytosis_Homo sapiens_hsa041440.67346745
71FoxO signaling pathway_Homo sapiens_hsa040680.65587670
72ABC transporters_Homo sapiens_hsa020100.65317921
73Choline metabolism in cancer_Homo sapiens_hsa052310.64782725
74Phagosome_Homo sapiens_hsa041450.63716771
75Inositol phosphate metabolism_Homo sapiens_hsa005620.61980851
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61798853
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.61506576
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61497501
79Chemokine signaling pathway_Homo sapiens_hsa040620.61049639
80Thyroid hormone synthesis_Homo sapiens_hsa049180.60904193
81Insulin signaling pathway_Homo sapiens_hsa049100.60459915
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59809436
83Renal cell carcinoma_Homo sapiens_hsa052110.59702397
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57781116
85Fatty acid biosynthesis_Homo sapiens_hsa000610.57182673
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56346142
87Osteoclast differentiation_Homo sapiens_hsa043800.55836236
88Rap1 signaling pathway_Homo sapiens_hsa040150.54732660
89VEGF signaling pathway_Homo sapiens_hsa043700.53747463
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53517434
91Cardiac muscle contraction_Homo sapiens_hsa042600.53388222
92Oocyte meiosis_Homo sapiens_hsa041140.52992464
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52771032
94Pancreatic cancer_Homo sapiens_hsa052120.52477045
95Regulation of autophagy_Homo sapiens_hsa041400.52292686
96Dilated cardiomyopathy_Homo sapiens_hsa054140.51598887
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51258416
98HIF-1 signaling pathway_Homo sapiens_hsa040660.49947302
99Leishmaniasis_Homo sapiens_hsa051400.48321116
100Alcoholism_Homo sapiens_hsa050340.48217838
101Type I diabetes mellitus_Homo sapiens_hsa049400.48005600
102Colorectal cancer_Homo sapiens_hsa052100.46456690
103Phototransduction_Homo sapiens_hsa047440.45580530
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45557731
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45508358
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.45299737
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.45287484
108AMPK signaling pathway_Homo sapiens_hsa041520.44746165
109African trypanosomiasis_Homo sapiens_hsa051430.44503841
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42855972
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39548147
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39542690
113Ovarian steroidogenesis_Homo sapiens_hsa049130.37489136
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37390721
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36621627
116Ether lipid metabolism_Homo sapiens_hsa005650.36546688
117Salmonella infection_Homo sapiens_hsa051320.35395338
118Endometrial cancer_Homo sapiens_hsa052130.35219085
119Glucagon signaling pathway_Homo sapiens_hsa049220.34218100
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33350845
121Tuberculosis_Homo sapiens_hsa051520.33103382
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32786646
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31834373
124Non-small cell lung cancer_Homo sapiens_hsa052230.31491746
125Melanoma_Homo sapiens_hsa052180.30785266

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