EPS15L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)4.45785189
2neutrophil activation involved in immune response (GO:0002283)3.93243482
3regulation of NFAT protein import into nucleus (GO:0051532)3.92215865
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85838778
5negative regulation of cell killing (GO:0031342)3.85838778
6negative regulation of histone methylation (GO:0031061)3.61654044
7nuclear pore complex assembly (GO:0051292)3.61379327
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60690549
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.60690549
10modulation by symbiont of host immune response (GO:0052553)3.60690549
11positive regulation by symbiont of host defense response (GO:0052509)3.60690549
12modulation by symbiont of host defense response (GO:0052031)3.60690549
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60690549
14neutrophil activation (GO:0042119)3.56380644
15glucocorticoid receptor signaling pathway (GO:0042921)3.52231597
16nuclear pore organization (GO:0006999)3.46653249
17regulation of sister chromatid cohesion (GO:0007063)3.37889187
18negative regulation of cAMP-mediated signaling (GO:0043951)3.36381294
19mitotic sister chromatid cohesion (GO:0007064)3.35065527
20histone H2A acetylation (GO:0043968)3.33718716
21histone H3-K4 trimethylation (GO:0080182)3.28664152
22positive regulation of granulocyte differentiation (GO:0030854)3.26335330
23regulation of B cell receptor signaling pathway (GO:0050855)3.24240053
24regulation of translational fidelity (GO:0006450)3.24168094
25regulation of mast cell degranulation (GO:0043304)3.20904314
26positive regulation of RNA splicing (GO:0033120)3.17867426
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16446543
28positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12257193
29positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12257193
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.12257193
31regulation of mast cell activation involved in immune response (GO:0033006)3.09687061
32B cell receptor signaling pathway (GO:0050853)3.08826762
33granulocyte activation (GO:0036230)3.06161914
34negative regulation of necroptotic process (GO:0060546)3.05391103
35leukocyte aggregation (GO:0070486)3.04847442
363-UTR-mediated mRNA stabilization (GO:0070935)3.04794941
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03864241
38peptidyl-lysine dimethylation (GO:0018027)3.02944018
39DNA unwinding involved in DNA replication (GO:0006268)3.00390925
40positive regulation of mast cell activation (GO:0033005)2.99566270
41histone H3-K4 methylation (GO:0051568)2.99512429
42mitotic nuclear envelope disassembly (GO:0007077)2.98955188
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94800379
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93676299
45hepatocyte apoptotic process (GO:0097284)2.92824495
46negative regulation of erythrocyte differentiation (GO:0045647)2.90278403
47cellular response to interleukin-15 (GO:0071350)2.89629998
48dosage compensation (GO:0007549)2.89322902
49megakaryocyte development (GO:0035855)2.88074650
50leukocyte migration involved in inflammatory response (GO:0002523)2.86541867
51negative regulation of necrotic cell death (GO:0060547)2.86308965
52regulation of mast cell activation (GO:0033003)2.85043163
53mitotic chromosome condensation (GO:0007076)2.84908895
54histone H3-K9 modification (GO:0061647)2.83835147
55activated T cell proliferation (GO:0050798)2.83338934
56membrane disassembly (GO:0030397)2.82895502
57nuclear envelope disassembly (GO:0051081)2.82895502
58germinal center formation (GO:0002467)2.82711399
59regulation of gamma-delta T cell activation (GO:0046643)2.82082163
60positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.80961609
61sister chromatid segregation (GO:0000819)2.79503310
62regulation of chromatin binding (GO:0035561)2.78336166
63protein localization to kinetochore (GO:0034501)2.77478399
64regulation of interferon-beta biosynthetic process (GO:0045357)2.76934572
65positive regulation of histone deacetylation (GO:0031065)2.76911567
66response to interleukin-15 (GO:0070672)2.76719720
67response to peptidoglycan (GO:0032494)2.76285547
68histone H2A monoubiquitination (GO:0035518)2.75855533
69paraxial mesoderm development (GO:0048339)2.75042311
70histone lysine methylation (GO:0034968)2.74681435
71positive regulation of gene expression, epigenetic (GO:0045815)2.74597621
72NLS-bearing protein import into nucleus (GO:0006607)2.74225073
73histone H3-K9 demethylation (GO:0033169)2.74146156
74macrophage activation involved in immune response (GO:0002281)2.73925858
75intracellular estrogen receptor signaling pathway (GO:0030520)2.72783205
76negative regulation of T-helper cell differentiation (GO:0045623)2.72670218
77negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72670218
78positive regulation of CREB transcription factor activity (GO:0032793)2.71542845
79corticosteroid receptor signaling pathway (GO:0031958)2.70367652
80regulation of necroptotic process (GO:0060544)2.69953970
81DNA geometric change (GO:0032392)2.68037952
82DNA duplex unwinding (GO:0032508)2.67525890
83response to host immune response (GO:0052572)2.66908464
84response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66908464
85regulation of T-helper 2 cell differentiation (GO:0045628)2.65747059
86histone H4 acetylation (GO:0043967)2.65537127
87regulation of histone H3-K9 methylation (GO:0051570)2.65387165
88peptidyl-lysine trimethylation (GO:0018023)2.64366747
89spliceosomal tri-snRNP complex assembly (GO:0000244)2.63990335
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62270743
91histone H4-K5 acetylation (GO:0043981)2.61284473
92histone H4-K8 acetylation (GO:0043982)2.61284473
93regulation of gamma-delta T cell differentiation (GO:0045586)2.60506924
94negative regulation of lymphocyte mediated immunity (GO:0002707)2.59253005
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58723182
96regulation of platelet aggregation (GO:0090330)2.58064563
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57942099
98regulation of regulated secretory pathway (GO:1903305)2.57169990
99mitotic sister chromatid segregation (GO:0000070)2.56542833
100oxygen transport (GO:0015671)2.56361396
101regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56350688
102positive regulation of chromosome segregation (GO:0051984)2.55790434
103regulation of RNA export from nucleus (GO:0046831)2.55719778
104neutrophil mediated immunity (GO:0002446)2.55097201
105poly(A)+ mRNA export from nucleus (GO:0016973)2.54843395
106protein insertion into membrane (GO:0051205)2.54248507
107regulation of leukocyte degranulation (GO:0043300)2.52896842
108histone H4-K16 acetylation (GO:0043984)2.52604045
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.50919913
110erythrocyte development (GO:0048821)2.49208672
111negative regulation of RNA splicing (GO:0033119)2.48830911
112pore complex assembly (GO:0046931)2.48671660
113ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.47875006
114myeloid cell development (GO:0061515)2.47461012
115histone methylation (GO:0016571)2.47377055
116response to muramyl dipeptide (GO:0032495)2.47080260
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.45620104
118protein kinase C signaling (GO:0070528)2.45391404
119negative regulation of histone modification (GO:0031057)2.44795039
120regulation of DNA damage checkpoint (GO:2000001)2.44663708
121positive regulation of T cell cytokine production (GO:0002726)2.43692700
122cell migration in hindbrain (GO:0021535)2.43639120
123histone H4-K12 acetylation (GO:0043983)2.43345332
124cardiac myofibril assembly (GO:0055003)2.43180775
125modulation by virus of host process (GO:0019054)2.42810921
126histone mRNA catabolic process (GO:0071044)2.42685241
127purinergic nucleotide receptor signaling pathway (GO:0035590)2.41758000
128positive regulation of mast cell degranulation (GO:0043306)2.41440693
129positive regulation of mast cell activation involved in immune response (GO:0033008)2.41440693
130peptidyl-arginine omega-N-methylation (GO:0035247)2.41426646
131regulation of mitotic spindle organization (GO:0060236)2.39890349
132nucleosome disassembly (GO:0006337)2.39745285
133protein-DNA complex disassembly (GO:0032986)2.39745285
134antigen processing and presentation of endogenous antigen (GO:0019883)2.37830166
135B cell homeostasis (GO:0001782)2.37771207
136histone H3-K9 methylation (GO:0051567)2.37515909
137leukocyte degranulation (GO:0043299)2.36822860
138positive regulation of interleukin-4 production (GO:0032753)2.36638790
139tolerance induction (GO:0002507)2.36181371
140retinoic acid receptor signaling pathway (GO:0048384)2.36084819
141regulation of spindle organization (GO:0090224)2.35868739
142positive regulation of SMAD protein import into nucleus (GO:0060391)2.34028918
143RNA stabilization (GO:0043489)2.33982121
144mRNA stabilization (GO:0048255)2.33982121
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.33860307
146response to host (GO:0075136)2.33860307
147response to host defenses (GO:0052200)2.33860307
148cellular extravasation (GO:0045123)2.33746679
149planar cell polarity pathway involved in neural tube closure (GO:0090179)2.33638618
150negative regulation of T cell mediated immunity (GO:0002710)2.32452067
151negative regulation of glial cell proliferation (GO:0060253)2.32295876
152regulation of T cell cytokine production (GO:0002724)2.31810240
153myeloid cell activation involved in immune response (GO:0002275)2.31279655
154nuclear envelope organization (GO:0006998)2.30724561
155positive regulation of gamma-delta T cell activation (GO:0046645)2.30693734
156negative regulation of chromatin modification (GO:1903309)2.30367925
157interkinetic nuclear migration (GO:0022027)2.30129309
158positive regulation of protein deacetylation (GO:0090312)2.29107253
159negative regulation of mRNA processing (GO:0050686)2.28640145
160positive regulation of B cell differentiation (GO:0045579)2.28400566
161regulation of defense response to virus by virus (GO:0050690)2.28041038
162negative regulation of cell size (GO:0045792)2.27538442
163negative regulation of interleukin-6 production (GO:0032715)2.26421992
164peptidyl-arginine modification (GO:0018195)2.26239151
165histone acetylation (GO:0016573)2.25406812
166regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.25122872
167defense response to protozoan (GO:0042832)2.25019035
168nodal signaling pathway (GO:0038092)2.24943753
169regulation of SMAD protein import into nucleus (GO:0060390)2.24824681
170negative regulation of gene expression, epigenetic (GO:0045814)2.24812350
171regulation of translational termination (GO:0006449)2.24640805
172histone lysine demethylation (GO:0070076)2.23794979
173heterochromatin organization (GO:0070828)2.22965302
174apoptotic process involved in morphogenesis (GO:0060561)2.21437102
175peptidyl-arginine methylation (GO:0018216)2.20781190
176peptidyl-arginine N-methylation (GO:0035246)2.20781190
177peptidyl-lysine methylation (GO:0018022)2.19923608
178negative regulation of DNA repair (GO:0045738)2.19824681
179internal peptidyl-lysine acetylation (GO:0018393)2.18631938
180negative regulation of mRNA metabolic process (GO:1903312)2.16005769
181heart morphogenesis (GO:0003007)2.15687941
182regulation of histone H3-K4 methylation (GO:0051569)2.14718309
183cytoplasmic mRNA processing body assembly (GO:0033962)2.14512025
184protein localization to chromosome, centromeric region (GO:0071459)2.13756027
185regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.12804243
186histone demethylation (GO:0016577)2.12310776
187establishment of nucleus localization (GO:0040023)2.12224175
188nucleus localization (GO:0051647)2.09198387
189positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.08720541
190positive regulation of cell cycle G2/M phase transition (GO:1902751)2.08720541
191postreplication repair (GO:0006301)2.08610694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68325729
2EZH2_22144423_ChIP-Seq_EOC_Human5.00083901
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.56965212
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.44174700
5* MYC_22102868_ChIP-Seq_BL_Human3.97193016
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27719115
7CIITA_25753668_ChIP-Seq_RAJI_Human2.76499594
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58862318
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.46177104
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34880482
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.31107344
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29667406
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.28362873
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23749927
15ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.21620741
16SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.20630468
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.18860473
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.14736552
19VDR_21846776_ChIP-Seq_THP-1_Human2.14124412
20KDM2B_26808549_Chip-Seq_DND41_Human2.12832288
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11137388
22TCF7_22412390_ChIP-Seq_EML_Mouse2.09238401
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.05459367
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98727967
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96787018
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.94705541
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93721293
28LXR_22292898_ChIP-Seq_THP-1_Human1.93526998
29SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.89803321
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88751775
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85651347
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85017307
33P68_20966046_ChIP-Seq_HELA_Human1.83971543
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83013426
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80949286
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80726681
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.77697623
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76129365
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.75683193
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74185029
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73757887
42MAF_26560356_Chip-Seq_TH2_Human1.68284321
43GATA1_19941826_ChIP-Seq_K562_Human1.62938777
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59196078
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.58415659
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57313732
47BCOR_27268052_Chip-Seq_Bcells_Human1.55931939
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.54857874
49* BCL6_27268052_Chip-Seq_Bcells_Human1.54057853
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53352021
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.52980784
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52744073
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51604585
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50760819
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.49235493
56RUNX_20019798_ChIP-Seq_JUKART_Human1.48901307
57UTX_26944678_Chip-Seq_JUKART_Human1.47624696
58* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47402515
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46126192
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45789332
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44741498
62SMC4_20622854_ChIP-Seq_HELA_Human1.43899461
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.43638794
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.42411530
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41188231
66* ELF1_20517297_ChIP-Seq_JURKAT_Human1.39967404
67SPI1_23127762_ChIP-Seq_K562_Human1.38841576
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38360754
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34243151
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.32526051
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31742064
72* OCT4_19829295_ChIP-Seq_ESCs_Human1.31493458
73MAF_26560356_Chip-Seq_TH1_Human1.30891672
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.30850351
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29478906
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28633189
77* ESR2_21235772_ChIP-Seq_MCF-7_Human1.28157812
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27614404
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27254143
80CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26896924
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26447409
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25446329
83E2F1_20622854_ChIP-Seq_HELA_Human1.24620176
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24474126
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24050461
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.23134329
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19938670
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19845069
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.19653117
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.19277165
91* RACK7_27058665_Chip-Seq_MCF-7_Human1.17239314
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17223553
93MYC_18555785_ChIP-Seq_MESCs_Mouse1.16643024
94ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16311883
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16275511
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15108627
97TFEB_21752829_ChIP-Seq_HELA_Human1.15051716
98GATA2_19941826_ChIP-Seq_K562_Human1.14531030
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14253966
100PHF8_20622854_ChIP-Seq_HELA_Human1.12908011
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12666333
102REST_21632747_ChIP-Seq_MESCs_Mouse1.11726655
103KDM5A_27292631_Chip-Seq_BREAST_Human1.10620228
104* KDM2B_26808549_Chip-Seq_K562_Human1.10189965
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10057415
106YY1_22570637_ChIP-Seq_MALME-3M_Human1.09650037
107SPI1_23547873_ChIP-Seq_NB4_Human1.09384062
108CREB1_26743006_Chip-Seq_LNCaP_Human1.09014897
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08359419
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08240503
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08164152
112IRF8_21731497_ChIP-ChIP_J774_Mouse1.08072576
113* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07129029
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05536928
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05450449
116* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05026201
117CTCF_26484167_Chip-Seq_Bcells_Mouse1.04655163
118ERA_21632823_ChIP-Seq_H3396_Human1.04165539
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03947697
120GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03519643
121BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03496123
122MYB_26560356_Chip-Seq_TH2_Human1.03288657
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02655748
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01765201
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01378675
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00914805
127SPI1_20517297_ChIP-Seq_HL60_Human1.00910362
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00601483
129CTCF_21964334_Chip-Seq_Bcells_Human1.00458672
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00403649
131YY1_21170310_ChIP-Seq_MESCs_Mouse1.00084945
132TP53_22127205_ChIP-Seq_IMR90_Human0.99413156
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.99252334
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99055181
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.98665749
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.98094560
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95163425
138* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94851617
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94413902
140* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93537338
141* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93216996
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92740632
143* TBX3_20139965_ChIP-Seq_ESCs_Mouse0.92647244
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91453372
145* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91189178
146SCL_19346495_ChIP-Seq_HPC-7_Human0.91151377
147* TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91101540
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.90378666
149XRN2_22483619_ChIP-Seq_HELA_Human0.90347690
150AR_21909140_ChIP-Seq_LNCAP_Human0.88722004
151SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.87779389
152* NCOR1_26117541_ChIP-Seq_K562_Human0.86133726
153* STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84748639
154DROSHA_22980978_ChIP-Seq_HELA_Human0.84240206
155VDR_24763502_ChIP-Seq_THP-1_Human0.84060050
156HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83943004
157RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83547804
158* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83410794
159MYB_26560356_Chip-Seq_TH1_Human0.83351724
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83204533
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83124712
162PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81400735
163GATA1_22025678_ChIP-Seq_K562_Human0.81001291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.69260273
2MP0003787_abnormal_imprinting3.00648661
3MP0005464_abnormal_platelet_physiology2.67762310
4MP0003121_genomic_imprinting2.57587569
5MP0003436_decreased_susceptibility_to2.50202218
6MP0003724_increased_susceptibility_to2.38893275
7MP0005451_abnormal_body_composition2.38273967
8MP0002396_abnormal_hematopoietic_system2.34214874
9MP0005076_abnormal_cell_differentiation2.33940383
10MP0003111_abnormal_nucleus_morphology2.30888677
11MP0010352_gastrointestinal_tract_polyps2.22300216
12MP0010094_abnormal_chromosome_stability2.16426188
13MP0002653_abnormal_ependyma_morphology2.12502012
14MP0003077_abnormal_cell_cycle2.12096618
15MP0004381_abnormal_hair_follicle2.09480240
16MP0003122_maternal_imprinting2.05144020
17MP0004130_abnormal_muscle_cell2.02063970
18MP0008057_abnormal_DNA_replication2.01182132
19MP0004084_abnormal_cardiac_muscle1.97899403
20MP0008961_abnormal_basal_metabolism1.95669350
21MP0003303_peritoneal_inflammation1.94691913
22MP0008260_abnormal_autophagy1.90868971
23MP0004145_abnormal_muscle_electrophysio1.81029951
24MP0005423_abnormal_somatic_nervous1.80714953
25MP0001835_abnormal_antigen_presentation1.80197264
26MP0001800_abnormal_humoral_immune1.78221201
27MP0003705_abnormal_hypodermis_morpholog1.77942938
28MP0004808_abnormal_hematopoietic_stem1.70901539
29MP0003123_paternal_imprinting1.69199027
30MP0004957_abnormal_blastocyst_morpholog1.68117719
31MP0000685_abnormal_immune_system1.68107178
32MP0005671_abnormal_response_to1.67491337
33MP0000350_abnormal_cell_proliferation1.64541700
34MP0005083_abnormal_biliary_tract1.63118101
35MP0002822_catalepsy1.62882719
36MP0002723_abnormal_immune_serum1.62401547
37MP0005387_immune_system_phenotype1.60996671
38MP0001790_abnormal_immune_system1.60996671
39MP0003984_embryonic_growth_retardation1.60467413
40MP0001986_abnormal_taste_sensitivity1.59188031
41MP0001672_abnormal_embryogenesis/_devel1.57790847
42MP0005380_embryogenesis_phenotype1.57790847
43MP0002420_abnormal_adaptive_immunity1.57439555
44MP0002088_abnormal_embryonic_growth/wei1.55930407
45MP0002084_abnormal_developmental_patter1.53269383
46MP0004233_abnormal_muscle_weight1.52786131
47MP0001819_abnormal_immune_cell1.52656418
48MP0000428_abnormal_craniofacial_morphol1.52368310
49MP0005000_abnormal_immune_tolerance1.51946285
50MP0001730_embryonic_growth_arrest1.50447652
51MP0005645_abnormal_hypothalamus_physiol1.50233814
52MP0008007_abnormal_cellular_replicative1.50126185
53MP0009278_abnormal_bone_marrow1.49997318
54MP0004197_abnormal_fetal_growth/weight/1.49203395
55MP0003635_abnormal_synaptic_transmissio1.46896799
56MP0002085_abnormal_embryonic_tissue1.44783938
57MP0005025_abnormal_response_to1.43040512
58MP0010307_abnormal_tumor_latency1.40976506
59MP0003693_abnormal_embryo_hatching1.40886181
60MP0002419_abnormal_innate_immunity1.40356013
61MP0002332_abnormal_exercise_endurance1.39325110
62MP0003191_abnormal_cellular_cholesterol1.38855288
63MP0001697_abnormal_embryo_size1.38660130
64MP0000733_abnormal_muscle_development1.38308166
65MP0002452_abnormal_antigen_presenting1.37592420
66MP0002086_abnormal_extraembryonic_tissu1.35318641
67MP0000716_abnormal_immune_system1.33560122
68MP0002735_abnormal_chemical_nociception1.30009338
69MP0003172_abnormal_lysosome_physiology1.28843677
70MP0003566_abnormal_cell_adhesion1.28288751
71MP0010030_abnormal_orbit_morphology1.27407127
72MP0000750_abnormal_muscle_regeneration1.25907997
73MP0003890_abnormal_embryonic-extraembry1.25527047
74MP0008569_lethality_at_weaning1.24904799
75MP0003656_abnormal_erythrocyte_physiolo1.24612023
76MP0000689_abnormal_spleen_morphology1.23359238
77MP0002733_abnormal_thermal_nociception1.22361776
78MP0003115_abnormal_respiratory_system1.20625755
79MP0002080_prenatal_lethality1.20600314
80MP0002722_abnormal_immune_system1.19567550
81MP0002925_abnormal_cardiovascular_devel1.18956731
82MP0001968_abnormal_touch/_nociception1.17974163
83MP0010630_abnormal_cardiac_muscle1.17937215
84MP0002063_abnormal_learning/memory/cond1.17343399
85MP0003567_abnormal_fetal_cardiomyocyte1.16943356
86MP0004264_abnormal_extraembryonic_tissu1.15365868
87MP0002064_seizures1.13818351
88MP0002132_abnormal_respiratory_system1.13086951
89MP0000703_abnormal_thymus_morphology1.12329884
90MP0002429_abnormal_blood_cell1.11701899
91MP0000751_myopathy1.10853066
92MP0003935_abnormal_craniofacial_develop1.10588319
93MP0004215_abnormal_myocardial_fiber1.09934898
94MP0000266_abnormal_heart_morphology1.07851997
95MP0000537_abnormal_urethra_morphology1.06776759
96MP0004087_abnormal_muscle_fiber1.06439871
97MP0005646_abnormal_pituitary_gland1.04898860
98MP0001915_intracranial_hemorrhage1.04722182
99MP0008877_abnormal_DNA_methylation1.04694571
100MP0000465_gastrointestinal_hemorrhage1.03978668
101MP0001348_abnormal_lacrimal_gland1.03833187
102MP0000749_muscle_degeneration1.03814045
103MP0009745_abnormal_behavioral_response1.03702853
104MP0003329_amyloid_beta_deposits1.02104617
105MP0004510_myositis1.02033008
106MP0009780_abnormal_chondrocyte_physiolo1.01750963
107MP0003091_abnormal_cell_migration1.00776528
108MP0008874_decreased_physiological_sensi1.00144158
109MP0003866_abnormal_defecation0.99833716
110MP0004859_abnormal_synaptic_plasticity0.99074240
111MP0003879_abnormal_hair_cell0.98938596
112MP0004036_abnormal_muscle_relaxation0.98926804
113MP0003183_abnormal_peptide_metabolism0.98104835
114MP0003385_abnormal_body_wall0.97885235
115MP0003119_abnormal_digestive_system0.97161665
116MP0008932_abnormal_embryonic_tissue0.97059954
117MP0000015_abnormal_ear_pigmentation0.96838510
118MP0009703_decreased_birth_body0.96329048
119MP0003279_aneurysm0.95767515
120MP0006276_abnormal_autonomic_nervous0.95346892
121MP0008058_abnormal_DNA_repair0.95333813
122MP0003646_muscle_fatigue0.94263193
123MP0001849_ear_inflammation0.93359111
124MP0005621_abnormal_cell_physiology0.93223616
125MP0003828_pulmonary_edema0.92797747
126MP0002269_muscular_atrophy0.92724360
127MP0009053_abnormal_anal_canal0.91242356
128MP0002877_abnormal_melanocyte_morpholog0.91156245
129MP0001545_abnormal_hematopoietic_system0.90560745
130MP0005397_hematopoietic_system_phenotyp0.90560745
131MP0002572_abnormal_emotion/affect_behav0.90257050
132MP0001970_abnormal_pain_threshold0.89531808
133MP0004484_altered_response_of0.89522991
134MP0002089_abnormal_postnatal_growth/wei0.89519806
135MP0005394_taste/olfaction_phenotype0.89265759
136MP0005499_abnormal_olfactory_system0.89265759
137MP0003861_abnormal_nervous_system0.89225255
138MP0005384_cellular_phenotype0.88720566
139MP0009046_muscle_twitch0.88656376
140MP0005623_abnormal_meninges_morphology0.87893385
141MP0005023_abnormal_wound_healing0.87884041
142MP0002106_abnormal_muscle_physiology0.86864549
143MP0009672_abnormal_birth_weight0.85454767
144MP0004142_abnormal_muscle_tone0.84973299
145MP0003880_abnormal_central_pattern0.84754541
146MP0002127_abnormal_cardiovascular_syste0.83257656
147MP0004811_abnormal_neuron_physiology0.83054456
148MP0006035_abnormal_mitochondrial_morpho0.82029874
149MP0002405_respiratory_system_inflammati0.81179301
150MP0003045_fibrosis0.80814776
151MP0001533_abnormal_skeleton_physiology0.80652331
152MP0001299_abnormal_eye_distance/0.80297535
153MP0002837_dystrophic_cardiac_calcinosis0.79811090
154MP0005075_abnormal_melanosome_morpholog0.79571339
155MP0004947_skin_inflammation0.79524130
156MP0006054_spinal_hemorrhage0.79486844
157MP0002398_abnormal_bone_marrow0.79299693
158MP0001529_abnormal_vocalization0.78889707
159MP0000759_abnormal_skeletal_muscle0.78520722
160MP0005386_behavior/neurological_phenoty0.78460870
161MP0004924_abnormal_behavior0.78460870
162MP0008004_abnormal_stomach_pH0.76418854
163MP0000313_abnormal_cell_death0.76195751
164MP0002148_abnormal_hypersensitivity_rea0.76010935
165MP0003755_abnormal_palate_morphology0.75679205
166MP0008770_decreased_survivor_rate0.74805278
167MP0002067_abnormal_sensory_capabilities0.74086827
168MP0000003_abnormal_adipose_tissue0.73785660
169MP0006036_abnormal_mitochondrial_physio0.73572285
170MP0009333_abnormal_splenocyte_physiolog0.73277459
171MP0002116_abnormal_craniofacial_bone0.73117662
172MP0003942_abnormal_urinary_system0.72012667
173MP0001293_anophthalmia0.71992469
174MP0005369_muscle_phenotype0.71820276
175MP0003221_abnormal_cardiomyocyte_apopto0.71440298
176MP0003763_abnormal_thymus_physiology0.70720191
177MP0004858_abnormal_nervous_system0.70277059

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.57969593
2Stomatitis (HP:0010280)3.90147942
3Volvulus (HP:0002580)3.73831535
4Abnormality of the fingertips (HP:0001211)3.66820047
5Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.55262649
6Hyperacusis (HP:0010780)3.29144570
7Short 4th metacarpal (HP:0010044)3.24471641
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24471641
9Petechiae (HP:0000967)3.24185979
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.11152325
11Recurrent abscess formation (HP:0002722)3.11025543
12Visual hallucinations (HP:0002367)3.10554546
13Ependymoma (HP:0002888)3.08712475
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.96213564
15Recurrent bacterial skin infections (HP:0005406)2.95839839
16Exercise-induced myalgia (HP:0003738)2.82765985
17Bundle branch block (HP:0011710)2.75978637
18Astrocytoma (HP:0009592)2.75483110
19Abnormality of the astrocytes (HP:0100707)2.75483110
20Renal duplication (HP:0000075)2.75435495
21Muscle fiber splitting (HP:0003555)2.74945350
22Trigonocephaly (HP:0000243)2.63649702
23Shallow orbits (HP:0000586)2.61644940
24EMG: neuropathic changes (HP:0003445)2.60942498
25Increased nuchal translucency (HP:0010880)2.60910538
26Epistaxis (HP:0000421)2.58259420
27Cerebral aneurysm (HP:0004944)2.57931489
28Eczematoid dermatitis (HP:0000976)2.57908742
29Long eyelashes (HP:0000527)2.56991018
30Genetic anticipation (HP:0003743)2.54282760
31Recurrent fungal infections (HP:0002841)2.51703813
32Elevated erythrocyte sedimentation rate (HP:0003565)2.50984009
33Encephalitis (HP:0002383)2.49724961
34Obstructive sleep apnea (HP:0002870)2.49304807
35Obstructive lung disease (HP:0006536)2.45145630
36Chronic obstructive pulmonary disease (HP:0006510)2.45145630
37Progressive cerebellar ataxia (HP:0002073)2.44414803
38Abnormality of binocular vision (HP:0011514)2.44214411
39Diplopia (HP:0000651)2.44214411
40Chest pain (HP:0100749)2.44122243
41Hypochromic microcytic anemia (HP:0004840)2.43695287
42Recurrent cutaneous fungal infections (HP:0011370)2.43587338
43Chronic mucocutaneous candidiasis (HP:0002728)2.43587338
44Myositis (HP:0100614)2.43245663
45Reticulocytosis (HP:0001923)2.42762922
46Muscle fiber inclusion bodies (HP:0100299)2.41144245
47Menorrhagia (HP:0000132)2.41006478
48Abnormal platelet volume (HP:0011876)2.39998951
49Elfin facies (HP:0004428)2.37374738
50Hyporeflexia of lower limbs (HP:0002600)2.37128608
51Broad thumb (HP:0011304)2.35905480
52Abnormality of the 4th metacarpal (HP:0010012)2.34401271
53Hypochromic anemia (HP:0001931)2.31095203
54Myopathic facies (HP:0002058)2.30579582
55Hand muscle atrophy (HP:0009130)2.30185759
56Ventricular fibrillation (HP:0001663)2.29713028
57Optic neuritis (HP:0100653)2.27511446
58Retrobulbar optic neuritis (HP:0100654)2.27511446
59Orchitis (HP:0100796)2.26832575
60Medulloblastoma (HP:0002885)2.26686591
61Spontaneous hematomas (HP:0007420)2.26439390
62Mediastinal lymphadenopathy (HP:0100721)2.26406409
63Abnormality of macrophages (HP:0004311)2.26139859
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.25555089
65Pointed chin (HP:0000307)2.25323070
66Easy fatigability (HP:0003388)2.24491233
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24263259
68Abnormality of the labia minora (HP:0012880)2.23948694
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23823436
70Glioma (HP:0009733)2.21720557
71Purpura (HP:0000979)2.21290086
72Insomnia (HP:0100785)2.12699626
73Ankle clonus (HP:0011448)2.11203475
74Subaortic stenosis (HP:0001682)2.10393318
75Abnormality of the left ventricular outflow tract (HP:0011103)2.10393318
76Myokymia (HP:0002411)2.08457317
77Narrow palate (HP:0000189)2.07926055
78Spinal muscular atrophy (HP:0007269)2.07919105
79Pachygyria (HP:0001302)2.06845620
80Panhypogammaglobulinemia (HP:0003139)2.06809054
81Nemaline bodies (HP:0003798)2.06391510
82Tented upper lip vermilion (HP:0010804)2.06068041
83Centrally nucleated skeletal muscle fibers (HP:0003687)2.05683265
84Meningitis (HP:0001287)2.05630628
85Urethral obstruction (HP:0000796)2.05237718
86Increased neuronal autofluorescent lipopigment (HP:0002074)2.04052968
87Distal lower limb muscle weakness (HP:0009053)2.03994319
88Gastrointestinal infarctions (HP:0005244)2.03935536
89Distal upper limb amyotrophy (HP:0007149)2.03896049
90Upper limb amyotrophy (HP:0009129)2.03896049
91Areflexia of lower limbs (HP:0002522)2.03642982
92Broad phalanges of the hand (HP:0009768)2.03332007
93Dysmetric saccades (HP:0000641)2.02945935
94Gastrointestinal inflammation (HP:0004386)2.00802261
95Increased IgE level (HP:0003212)2.00624868
96Renovascular hypertension (HP:0100817)2.00036837
97Lissencephaly (HP:0001339)1.99718706
98Hyperventilation (HP:0002883)1.98829732
99Macroorchidism (HP:0000053)1.97791033
100Broad palm (HP:0001169)1.97499879
101Hypoplastic labia majora (HP:0000059)1.94906260
102Shawl scrotum (HP:0000049)1.94078494
103Difficulty running (HP:0009046)1.93309119
104Gingival bleeding (HP:0000225)1.92697012
105Broad finger (HP:0001500)1.92691849
106Overriding aorta (HP:0002623)1.92404574
107Abnormal gallbladder physiology (HP:0012438)1.92282381
108Cholecystitis (HP:0001082)1.92282381
109Intellectual disability, severe (HP:0010864)1.92085979
110Bowel diverticulosis (HP:0005222)1.92021921
111EMG: myopathic abnormalities (HP:0003458)1.91758832
112Recurrent skin infections (HP:0001581)1.91636786
113Clumsiness (HP:0002312)1.89212895
114Skull defect (HP:0001362)1.88310179
115Abnormality of the endocardium (HP:0004306)1.87929680
116Abnormality of the aortic arch (HP:0012303)1.87411220
117Neuronal loss in central nervous system (HP:0002529)1.87350877
118Spastic gait (HP:0002064)1.87290466
119Hypoplastic ischia (HP:0003175)1.87075917
120Urticaria (HP:0001025)1.86230418
121Aplasia/Hypoplasia of the sternum (HP:0006714)1.85789919
122Neoplasm of the heart (HP:0100544)1.85311836
123Ectopic kidney (HP:0000086)1.84934594
124Inflammation of the large intestine (HP:0002037)1.84462390
125Neoplasm of the oral cavity (HP:0100649)1.84391770
126Abnormality of the columella (HP:0009929)1.82875027
127Overlapping toe (HP:0001845)1.82486245
128Broad phalanx (HP:0006009)1.82235631
129Increased cerebral lipofuscin (HP:0011813)1.82050976
130Distal lower limb amyotrophy (HP:0008944)1.81733094
131Heterotopia (HP:0002282)1.81240846
132Hypercortisolism (HP:0001578)1.80911777
133Frequent falls (HP:0002359)1.80686351
134Sacral dimple (HP:0000960)1.79980288
135Obsessive-compulsive behavior (HP:0000722)1.78134048
136Increased mean platelet volume (HP:0011877)1.78095908
137Absent frontal sinuses (HP:0002688)1.77881413
138Skin tags (HP:0010609)1.77807640
139Supranuclear gaze palsy (HP:0000605)1.77466584
140Deviation of the thumb (HP:0009603)1.76711121
141Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76312131
142Poor eye contact (HP:0000817)1.76144022
143Cholelithiasis (HP:0001081)1.76062598
144Flat cornea (HP:0007720)1.75930709
145Progressive microcephaly (HP:0000253)1.75196383
146Supernumerary ribs (HP:0005815)1.75036411
147Papillary thyroid carcinoma (HP:0002895)1.75018407
148Episodic fever (HP:0001954)1.74903114
149Urinary bladder sphincter dysfunction (HP:0002839)1.73910224
150Increased density of long bones (HP:0006392)1.72767081
151Slow saccadic eye movements (HP:0000514)1.72402825
152Gastrointestinal stroma tumor (HP:0100723)1.70754317
153Proximal placement of thumb (HP:0009623)1.70331320
154Limited elbow extension (HP:0001377)1.69810167
155Increased IgM level (HP:0003496)1.69810012
156Patellar aplasia (HP:0006443)1.68594950
157Arterial thrombosis (HP:0004420)1.68062359
158Broad long bones (HP:0005622)1.67979811
159Abnormality of the labia majora (HP:0012881)1.67965043
160Cutis marmorata (HP:0000965)1.67777474
161Aneurysm (HP:0002617)1.67566633
162Depressed nasal tip (HP:0000437)1.65595785
163Broad metatarsal (HP:0001783)1.64010321
164Bladder diverticulum (HP:0000015)1.63292492
165Abnormality of the diencephalon (HP:0010662)1.62401316
166Deep philtrum (HP:0002002)1.62339662
167Abnormal number of incisors (HP:0011064)1.61493199
168Hypoplasia of the maxilla (HP:0000327)1.61422049
169Long palpebral fissure (HP:0000637)1.59807267
170Agnosia (HP:0010524)1.59580536
171Vertebral arch anomaly (HP:0008438)1.57527382
172Bicuspid aortic valve (HP:0001647)1.56591976
173Abnormality of the carotid arteries (HP:0005344)1.56399282
174Broad alveolar ridges (HP:0000187)1.56073478
175Abnormality of the lower motor neuron (HP:0002366)1.55734250
176Abnormality of the ischium (HP:0003174)1.55358762
177Preauricular skin tag (HP:0000384)1.55346036
178Abnormality of the intervertebral disk (HP:0005108)1.55249535
179Supernumerary bones of the axial skeleton (HP:0009144)1.55231720
180Prominent nose (HP:0000448)1.55221944
181Megalocornea (HP:0000485)1.54515470
182Truncal obesity (HP:0001956)1.53051208
183Neoplasm of striated muscle (HP:0009728)1.53041440
184Fibroma (HP:0010614)1.52244344
185Anal stenosis (HP:0002025)1.52123258
186Basal cell carcinoma (HP:0002671)1.51920326
187Low anterior hairline (HP:0000294)1.51542094
188Aortic aneurysm (HP:0004942)1.51457501
189Cafe-au-lait spot (HP:0000957)1.51089646
190Fibrous tissue neoplasm (HP:0012316)1.50941047
191Enlarged penis (HP:0000040)1.49339116
192Dislocated radial head (HP:0003083)1.49137724
193Abnormality of chromosome segregation (HP:0002916)1.49128560
194Abnormality of the nasal septum (HP:0000419)1.48720030
195Benign neoplasm of the central nervous system (HP:0100835)1.48535270
196Aplasia/Hypoplasia of the patella (HP:0006498)1.47992418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.26908383
2MAP3K103.20600125
3RIPK43.02974378
4EEF2K2.88630202
5TRIB32.77931400
6PKN22.65078951
7PASK2.57578585
8MAP3K112.38575932
9TNK22.34870009
10CDC72.30666565
11MAP2K32.29706717
12TTN2.15879027
13ACVR1B2.14017300
14SIK22.12625902
15BRD42.05753494
16NEK22.02338857
17SMG11.94835003
18NEK11.89795637
19GRK61.85648094
20IRAK41.78853194
21TSSK61.67291002
22PDGFRA1.58210178
23LATS21.57002826
24PRKD21.56885459
25LATS11.54502722
26EPHB11.52515237
27DAPK21.50686188
28MTOR1.49946785
29MAP3K41.48598776
30BTK1.47712391
31NTRK21.45238878
32TAOK31.40091211
33DMPK1.39158033
34CAMK1D1.35698143
35ALK1.33388880
36FES1.29871324
37SIK31.25970767
38MAP2K41.25852301
39ICK1.22278345
40SYK1.21285380
41MAPK131.20419707
42ATR1.20161355
43MAP4K11.18825284
44CAMK1G1.17932595
45MARK11.17541760
46DYRK1B1.17466470
47MAPK121.17064313
48MAPKAPK31.17021241
49TESK21.16582735
50MAP3K61.14858694
51KSR21.11946365
52BLK1.10211174
53CDC42BPA1.08113917
54CAMKK11.06657272
55STK31.06179839
56TGFBR11.05000642
57STK241.03725395
58PDK11.03561526
59OBSCN1.03286608
60SGK31.02100696
61CSF1R1.01514532
62PDGFRB1.01135115
63FGFR11.00252626
64CHEK11.00229096
65RPS6KB20.98261321
66MAP3K10.97657783
67MAP3K130.96764468
68STK100.96404117
69ZAP700.94385117
70SCYL20.94168897
71CDK70.93205379
72PRKD30.93174357
73PAK40.92383278
74PTK2B0.91233837
75KSR10.90179836
76TAOK20.88404589
77CAMK10.87960737
78RIPK10.87029028
79HIPK20.86764346
80TXK0.86678120
81MAP2K70.85867522
82PRPF4B0.85238005
83PDPK10.84250819
84CDK20.84032876
85MAP2K20.83567267
86CSK0.82057490
87CAMK40.81447047
88IKBKB0.81220246
89MAPK110.80727840
90CDK40.80456973
91MARK30.79956540
92ATM0.75902536
93TTK0.75610156
94ERN10.75483959
95CCNB10.74964533
96BMX0.74746837
97PRKCH0.72741136
98PHKG10.72690984
99PHKG20.72690984
100MAP3K70.71557593
101TYRO30.71315474
102PRKCZ0.70276410
103RET0.68464418
104JAK20.68057066
105DYRK20.68003563
106PTK60.67999272
107DAPK10.66152609
108DYRK1A0.66100944
109CDK10.65320608
110PRKD10.64370008
111STK110.63773107
112KIT0.63737260
113LYN0.61344258
114MAP3K50.61178075
115MAP2K10.60300955
116SIK10.59162994
117IRAK10.58316182
118CDK190.58279438
119MAP3K90.57678832
120FGFR30.57244575
121RPS6KA20.57151121
122PIK3CG0.56968075
123FGR0.56145787
124CHUK0.55691263
125JAK30.55383007
126PRKAA10.54829302
127RAF10.54751404
128MAPK140.54659113
129MAP3K30.54378062
130ITK0.53979215
131TBK10.53788428
132MAPK80.53270265
133CHEK20.53100224
134LRRK20.53023760
135TAOK10.52724267
136NME10.51016109
137* GSK3B0.50573590
138PTK20.49417669
139TGFBR20.49304305
140GRK50.47566261
141ROCK10.47389779
142IRAK20.47363607
143FLT30.46829253
144ILK0.46301840
145SGK20.46072158
146AKT10.45793647
147IKBKE0.45728900
148TYK20.45403312
149CDK50.45314490
150MAP3K80.45154252
151PRKDC0.44635650
152PAK60.44630148
153AKT30.44626522
154PLK30.43479438
155CSNK1D0.43467119
156UHMK10.42673683
157MARK20.42586805
158ERBB20.40991351
159MAPK10.40863270
160STK380.40783564
161PLK10.40780967
162* MAPK100.40497539
163HCK0.39836075
164FGFR20.38429961
165DDR20.38313001
166PAK20.38260196
167RPS6KC10.37054566
168RPS6KL10.37054566

Predicted pathways (KEGG)

RankGene SetZ-score
1mTOR signaling pathway_Homo sapiens_hsa041501.69067417
2Chronic myeloid leukemia_Homo sapiens_hsa052201.54806597
3Primary immunodeficiency_Homo sapiens_hsa053401.48857266
4Cell cycle_Homo sapiens_hsa041101.48713309
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42672553
6Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42294408
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41792986
8mRNA surveillance pathway_Homo sapiens_hsa030151.41536354
9Colorectal cancer_Homo sapiens_hsa052101.39946734
10Type II diabetes mellitus_Homo sapiens_hsa049301.33993873
11Non-small cell lung cancer_Homo sapiens_hsa052231.33835006
12Endometrial cancer_Homo sapiens_hsa052131.32657006
13Notch signaling pathway_Homo sapiens_hsa043301.31779131
14Chemokine signaling pathway_Homo sapiens_hsa040621.31618373
15Synaptic vesicle cycle_Homo sapiens_hsa047211.30648333
16Glioma_Homo sapiens_hsa052141.27889002
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27869591
18Base excision repair_Homo sapiens_hsa034101.27661171
19MicroRNAs in cancer_Homo sapiens_hsa052061.26696825
20Neurotrophin signaling pathway_Homo sapiens_hsa047221.26574513
21DNA replication_Homo sapiens_hsa030301.25296441
22Pancreatic cancer_Homo sapiens_hsa052121.22209591
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21849776
24Lysine degradation_Homo sapiens_hsa003101.21461677
25RNA transport_Homo sapiens_hsa030131.20821157
26Inositol phosphate metabolism_Homo sapiens_hsa005621.16535406
27Tuberculosis_Homo sapiens_hsa051521.16192226
28Spliceosome_Homo sapiens_hsa030401.15386111
29Dilated cardiomyopathy_Homo sapiens_hsa054141.15356886
30Adherens junction_Homo sapiens_hsa045201.13956929
31Mismatch repair_Homo sapiens_hsa034301.13608774
32Acute myeloid leukemia_Homo sapiens_hsa052211.12515194
33Cholinergic synapse_Homo sapiens_hsa047251.11958725
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.11806844
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11668059
36Small cell lung cancer_Homo sapiens_hsa052221.11105469
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11037733
38GnRH signaling pathway_Homo sapiens_hsa049121.07968307
39HTLV-I infection_Homo sapiens_hsa051661.07875231
40Morphine addiction_Homo sapiens_hsa050321.07460736
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06352329
42Leishmaniasis_Homo sapiens_hsa051401.06113597
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05947335
44Viral myocarditis_Homo sapiens_hsa054161.05016275
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04387334
46B cell receptor signaling pathway_Homo sapiens_hsa046621.04291690
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03632045
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02578381
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02386717
50Basal cell carcinoma_Homo sapiens_hsa052171.02189362
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02030512
52AMPK signaling pathway_Homo sapiens_hsa041521.01688093
53Proteoglycans in cancer_Homo sapiens_hsa052051.00787761
54* Endocytosis_Homo sapiens_hsa041441.00277956
55Adipocytokine signaling pathway_Homo sapiens_hsa049201.00075775
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98799761
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98593964
58Estrogen signaling pathway_Homo sapiens_hsa049150.98281035
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97917270
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96929150
61Long-term depression_Homo sapiens_hsa047300.94534023
62Dorso-ventral axis formation_Homo sapiens_hsa043200.94052212
63Viral carcinogenesis_Homo sapiens_hsa052030.93716445
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93282262
65HIF-1 signaling pathway_Homo sapiens_hsa040660.93274493
66Renal cell carcinoma_Homo sapiens_hsa052110.91465223
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90979015
68Hippo signaling pathway_Homo sapiens_hsa043900.90709302
69Oocyte meiosis_Homo sapiens_hsa041140.89977556
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89718091
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.89333540
72Focal adhesion_Homo sapiens_hsa045100.86947028
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86624303
74GABAergic synapse_Homo sapiens_hsa047270.86253920
75Sulfur relay system_Homo sapiens_hsa041220.85171937
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84838431
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84785907
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84665914
79Hepatitis B_Homo sapiens_hsa051610.84636318
80Epstein-Barr virus infection_Homo sapiens_hsa051690.84633401
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.84185975
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.82843862
83Non-homologous end-joining_Homo sapiens_hsa034500.82725874
84ErbB signaling pathway_Homo sapiens_hsa040120.82332905
85T cell receptor signaling pathway_Homo sapiens_hsa046600.82288397
86Hepatitis C_Homo sapiens_hsa051600.81940741
87Toxoplasmosis_Homo sapiens_hsa051450.81592173
88Insulin signaling pathway_Homo sapiens_hsa049100.80329268
89FoxO signaling pathway_Homo sapiens_hsa040680.79818374
90Pathways in cancer_Homo sapiens_hsa052000.79584996
91Calcium signaling pathway_Homo sapiens_hsa040200.78879546
92p53 signaling pathway_Homo sapiens_hsa041150.78741138
93Prostate cancer_Homo sapiens_hsa052150.78621620
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78300365
95Insulin resistance_Homo sapiens_hsa049310.77895907
96Dopaminergic synapse_Homo sapiens_hsa047280.77332201
97Rap1 signaling pathway_Homo sapiens_hsa040150.77121433
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76928246
99TNF signaling pathway_Homo sapiens_hsa046680.76513227
100Long-term potentiation_Homo sapiens_hsa047200.76437118
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76394741
102Osteoclast differentiation_Homo sapiens_hsa043800.76305401
103Gastric acid secretion_Homo sapiens_hsa049710.76116359
104Melanoma_Homo sapiens_hsa052180.76104624
105Herpes simplex infection_Homo sapiens_hsa051680.75961902
106Influenza A_Homo sapiens_hsa051640.75792321
107Oxytocin signaling pathway_Homo sapiens_hsa049210.75701066
108MAPK signaling pathway_Homo sapiens_hsa040100.75297878
109Thyroid cancer_Homo sapiens_hsa052160.74770260
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74317720
111VEGF signaling pathway_Homo sapiens_hsa043700.73147637
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73081301
113Hedgehog signaling pathway_Homo sapiens_hsa043400.72788429
114Gap junction_Homo sapiens_hsa045400.72555031
115Wnt signaling pathway_Homo sapiens_hsa043100.72548202
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71505550
117Choline metabolism in cancer_Homo sapiens_hsa052310.70704320
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70047261
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69911969
120Bladder cancer_Homo sapiens_hsa052190.69816096
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69791582
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.69152624
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69126530
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.68810723
125Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67281595
126Platelet activation_Homo sapiens_hsa046110.67114271
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66549494
128Apoptosis_Homo sapiens_hsa042100.65771689
129Olfactory transduction_Homo sapiens_hsa047400.65334108
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64963947
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64545180
132TGF-beta signaling pathway_Homo sapiens_hsa043500.64544410
133Glutamatergic synapse_Homo sapiens_hsa047240.64090370
134Prolactin signaling pathway_Homo sapiens_hsa049170.63556270
135Melanogenesis_Homo sapiens_hsa049160.63246085
136Circadian entrainment_Homo sapiens_hsa047130.63123790
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62433319
138Measles_Homo sapiens_hsa051620.62424238
139RNA degradation_Homo sapiens_hsa030180.62408235
140cAMP signaling pathway_Homo sapiens_hsa040240.62138568
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.61847909
142Shigellosis_Homo sapiens_hsa051310.61824761
143Hematopoietic cell lineage_Homo sapiens_hsa046400.60850403
144Ovarian steroidogenesis_Homo sapiens_hsa049130.58702144
145Ras signaling pathway_Homo sapiens_hsa040140.58322321

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