EPS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1secondary metabolite biosynthetic process (GO:0044550)9.78438530
2developmental pigmentation (GO:0048066)4.60345112
3collagen fibril organization (GO:0030199)4.27079960
4regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.20957463
5secondary metabolic process (GO:0019748)4.14836212
6mesenchymal-epithelial cell signaling (GO:0060638)3.90035254
7phenol-containing compound biosynthetic process (GO:0046189)3.77036720
8regulation of integrin-mediated signaling pathway (GO:2001044)3.75951404
9retina vasculature morphogenesis in camera-type eye (GO:0061299)3.48656760
10intestinal absorption (GO:0050892)3.48285928
11tyrosine metabolic process (GO:0006570)3.46429616
12skin morphogenesis (GO:0043589)3.45705428
13angiotensin maturation (GO:0002003)3.45625934
14protein heterotrimerization (GO:0070208)3.44678100
15regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.43159546
16regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39294519
17extracellular fibril organization (GO:0043206)3.38601304
18peptide catabolic process (GO:0043171)3.33896839
19positive regulation of p38MAPK cascade (GO:1900745)3.28847261
20endodermal cell differentiation (GO:0035987)3.26830691
21sequestering of extracellular ligand from receptor (GO:0035581)3.26689875
22cell migration involved in heart development (GO:0060973)3.20849472
23kidney mesenchyme development (GO:0072074)3.14795438
24hemidesmosome assembly (GO:0031581)3.14562740
25apoptotic cell clearance (GO:0043277)3.13667165
26maintenance of gastrointestinal epithelium (GO:0030277)3.12594562
27desmosome organization (GO:0002934)3.10490452
28basement membrane organization (GO:0071711)3.07350162
29negative regulation of chondrocyte differentiation (GO:0032331)3.06752133
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05568942
31regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.05162266
32metanephric mesenchyme development (GO:0072075)2.99828788
33membrane raft organization (GO:0031579)2.98355070
34glomerular basement membrane development (GO:0032836)2.97992279
35renal filtration (GO:0097205)2.97105695
36regulation of metalloenzyme activity (GO:0048552)2.95664021
37cGMP-mediated signaling (GO:0019934)2.91724604
38protein retention in ER lumen (GO:0006621)2.89922681
39production of molecular mediator involved in inflammatory response (GO:0002532)2.89884877
40UDP-N-acetylglucosamine metabolic process (GO:0006047)2.88281516
41fibril organization (GO:0097435)2.87727913
42substrate adhesion-dependent cell spreading (GO:0034446)2.87597305
43positive regulation of macrophage cytokine production (GO:0060907)2.84994316
44negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.83885157
45glomerular filtration (GO:0003094)2.82381783
46vascular endothelial growth factor signaling pathway (GO:0038084)2.81822633
47sodium ion export (GO:0071436)2.81028265
48actin filament depolymerization (GO:0030042)2.77310576
49smooth muscle tissue development (GO:0048745)2.73000851
50negative regulation of fatty acid transport (GO:2000192)2.72284554
51positive regulation of extracellular matrix organization (GO:1903055)2.71864754
52dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70536010
53protein localization to cell surface (GO:0034394)2.67721223
54extracellular matrix assembly (GO:0085029)2.67674292
55cellular potassium ion homeostasis (GO:0030007)2.67524796
56peptidyl-proline hydroxylation (GO:0019511)2.67094744
57cell adhesion mediated by integrin (GO:0033627)2.65970346
58iron ion import (GO:0097286)2.64179434
59negative regulation of hormone metabolic process (GO:0032351)2.63382070
60negative regulation of hormone biosynthetic process (GO:0032353)2.63382070
61regulation of hydrogen peroxide-induced cell death (GO:1903205)2.62950477
62COPII vesicle coating (GO:0048208)2.61161465
63O-glycan processing (GO:0016266)2.60763165
64substrate-dependent cell migration (GO:0006929)2.60704735
65negative regulation of anoikis (GO:2000811)2.60023016
66bone remodeling (GO:0046849)2.59846222
67melanocyte differentiation (GO:0030318)2.59341841
68regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.57326520
69aminoglycoside antibiotic metabolic process (GO:0030647)2.57266179
70fibroblast migration (GO:0010761)2.56430927
71positive regulation of neuroblast proliferation (GO:0002052)2.56004177
72regulation of plasminogen activation (GO:0010755)2.53132368
73cellular response to vitamin D (GO:0071305)2.52937819
74positive regulation of actin filament depolymerization (GO:0030836)2.52777202
75relaxation of cardiac muscle (GO:0055119)2.52626101
76embryonic camera-type eye morphogenesis (GO:0048596)2.50875797
77multicellular organismal macromolecule metabolic process (GO:0044259)2.50459842
78negative regulation of cartilage development (GO:0061037)2.50150938
79protein hydroxylation (GO:0018126)2.49214607
80pigment cell differentiation (GO:0050931)2.48728562
81primary alcohol catabolic process (GO:0034310)2.48640566
82intestinal cholesterol absorption (GO:0030299)2.47752157
83endothelial cell morphogenesis (GO:0001886)2.47214758
84regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.46813983
85regulation of axon extension involved in axon guidance (GO:0048841)2.46672651
86collagen metabolic process (GO:0032963)2.46315465
87daunorubicin metabolic process (GO:0044597)2.45349951
88polyketide metabolic process (GO:0030638)2.45349951
89doxorubicin metabolic process (GO:0044598)2.45349951
90extracellular matrix organization (GO:0030198)2.45348384
91multicellular organismal metabolic process (GO:0044236)2.45215839
92oligosaccharide catabolic process (GO:0009313)2.45065536
93regulation of endothelial cell chemotaxis (GO:2001026)2.45006616
94Golgi transport vesicle coating (GO:0048200)2.44995782
95COPI coating of Golgi vesicle (GO:0048205)2.44995782
96embryonic cranial skeleton morphogenesis (GO:0048701)2.44847353
97regulation of interferon-beta biosynthetic process (GO:0045357)2.44842163
98positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.44490863
99extracellular structure organization (GO:0043062)2.44444412
100regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44265354
101regulation of chondrocyte differentiation (GO:0032330)2.44120996
102regulation of integrin activation (GO:0033623)2.43482858
103negative regulation of nitric-oxide synthase activity (GO:0051001)2.43198047
104membrane assembly (GO:0071709)2.43121297
105chondrocyte proliferation (GO:0035988)2.43059505
106regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.42500884
107L-serine transport (GO:0015825)2.41898186
108renal absorption (GO:0070293)2.41815246
109vitamin A metabolic process (GO:0006776)2.41517504
110maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41513298
111negative regulation of protein localization to cell surface (GO:2000009)2.40891950
112muscle cell migration (GO:0014812)2.40051812
113wound healing, spreading of epidermal cells (GO:0035313)2.39552469
114extracellular matrix disassembly (GO:0022617)2.39238306
115hepatocyte apoptotic process (GO:0097284)2.39144845
116negative regulation of catenin import into nucleus (GO:0035414)2.38714394
117cell-matrix adhesion (GO:0007160)2.38090841
118protein targeting to Golgi (GO:0000042)2.37110094
119regulation of extracellular matrix disassembly (GO:0010715)2.36866973
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.36664519
121regulation of p38MAPK cascade (GO:1900744)2.35903442
122chondrocyte development (GO:0002063)2.35308451
123negative regulation of axon extension involved in axon guidance (GO:0048843)2.34900097
124negative regulation of response to reactive oxygen species (GO:1901032)2.34824733
125ketone body metabolic process (GO:1902224)2.34371376
126cellular response to vitamin (GO:0071295)2.34269886
127bicarbonate transport (GO:0015701)2.33740912
128cytoskeletal anchoring at plasma membrane (GO:0007016)2.32945701
129negative regulation of smooth muscle cell migration (GO:0014912)2.31822158
130dermatan sulfate biosynthetic process (GO:0030208)2.31265895
131cell-substrate adhesion (GO:0031589)2.30943433
132muscle cell cellular homeostasis (GO:0046716)2.29485861
133cell-substrate junction assembly (GO:0007044)2.28895284
134regulation of axon guidance (GO:1902667)2.28209736
135type B pancreatic cell proliferation (GO:0044342)2.28152401
136virion attachment to host cell (GO:0019062)2.28130068
137adhesion of symbiont to host cell (GO:0044650)2.28130068
138collagen catabolic process (GO:0030574)2.26933838
139negative regulation of complement activation (GO:0045916)2.26401149
140positive regulation of cellular amide metabolic process (GO:0034250)2.26292509
141adhesion of symbiont to host (GO:0044406)2.24903507
142multicellular organismal catabolic process (GO:0044243)2.24775555
143neural crest cell development (GO:0014032)2.24744868
144endocardial cushion development (GO:0003197)2.24460396
145positive regulation of endothelial cell apoptotic process (GO:2000353)2.24261569
146glomerular epithelial cell development (GO:0072310)2.23569887
147sulfur compound transport (GO:0072348)2.23503525
148regulation of neuroblast proliferation (GO:1902692)2.23151717
149intestinal epithelial cell development (GO:0060576)2.21278405
150hormone catabolic process (GO:0042447)2.20716961
151positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20471970
152toxin transport (GO:1901998)2.20229342
153striated muscle atrophy (GO:0014891)2.19072848
154regulation of transforming growth factor beta2 production (GO:0032909)2.18710492
155regulation of early endosome to late endosome transport (GO:2000641)2.18006476
156lipoprotein transport (GO:0042953)2.17804484
157keratan sulfate catabolic process (GO:0042340)2.15637123
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.15052702
159regulation of chemokine secretion (GO:0090196)2.14943467
160protein localization to endosome (GO:0036010)2.13598136
161positive regulation vascular endothelial growth factor production (GO:0010575)2.11831197
162epithelial cell-cell adhesion (GO:0090136)2.11415793
163establishment of protein localization to Golgi (GO:0072600)2.11014113
164glycoside metabolic process (GO:0016137)2.09951515
165epithelial structure maintenance (GO:0010669)2.09784920
166actin nucleation (GO:0045010)2.09502069
167positive regulation of protein localization to plasma membrane (GO:1903078)2.09194108
168response to hepatocyte growth factor (GO:0035728)2.09142275
169cellular response to hepatocyte growth factor stimulus (GO:0035729)2.09142275
170semaphorin-plexin signaling pathway (GO:0071526)2.08822560
171pigmentation (GO:0043473)2.08489543
172positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.08050769
173growth hormone receptor signaling pathway (GO:0060396)2.07878794
174positive regulation of leukocyte degranulation (GO:0043302)2.07740665
175melanin biosynthetic process (GO:0042438)11.7361212
176melanin metabolic process (GO:0006582)10.4684945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.83084765
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.07599611
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65779231
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.65119588
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.58978755
6* CDX2_20551321_ChIP-Seq_CACO-2_Human2.50083074
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26377003
8ZNF217_24962896_ChIP-Seq_MCF-7_Human2.18456874
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.11166343
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.10197370
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.09333971
12SOX2_20726797_ChIP-Seq_SW620_Human2.08461607
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.05642521
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.03552406
15CJUN_26792858_Chip-Seq_BT549_Human2.00009169
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83010425
17* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81566363
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80227039
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75247095
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75139915
21FOXO3_23340844_ChIP-Seq_DLD1_Human1.72597620
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70487157
23TP53_16413492_ChIP-PET_HCT116_Human1.69805355
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.68960240
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66950858
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.62900315
27VDR_24787735_ChIP-Seq_THP-1_Human1.62249075
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61499076
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.60617223
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.57031757
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.55618098
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53916771
33* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53916771
34* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.53766104
35* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.52710705
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52507076
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.52191733
38KLF5_25053715_ChIP-Seq_YYC3_Human1.52021608
39GATA6_25053715_ChIP-Seq_YYC3_Human1.51194075
40* GATA4_25053715_ChIP-Seq_YYC3_Human1.50124287
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.48837489
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.44081018
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42380537
44* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42214568
45GBX2_23144817_ChIP-Seq_PC3_Human1.42089137
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41712709
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.40570881
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40508712
49CLOCK_20551151_ChIP-Seq_293T_Human1.39198740
50BRD4_25478319_ChIP-Seq_HGPS_Human1.38342831
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37973980
52TP53_18474530_ChIP-ChIP_U2OS_Human1.37957709
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37774545
54NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37541102
55NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37541102
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37364657
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35236039
58FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35137903
59* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34132047
60RXR_22108803_ChIP-Seq_LS180_Human1.33430666
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29473238
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28695251
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28034437
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27950043
65SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27476387
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26830234
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26509929
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26435593
69TP63_23658742_ChIP-Seq_EP156T_Human1.26359946
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25788114
71RXR_22158963_ChIP-Seq_LIVER_Mouse1.25142444
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24141781
73* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23360389
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.21407542
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21152957
76* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20664254
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.20017224
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19729875
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19015620
80* TBX20_22080862_ChIP-Seq_HEART_Mouse1.18954920
81* TBX20_22328084_ChIP-Seq_HEART_Mouse1.18954920
82* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.17680186
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17581122
84* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13398969
85AHR_22903824_ChIP-Seq_MCF-7_Human1.13315920
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12130890
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.11783762
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11091425
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10638519
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.09911180
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09898224
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09719912
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07493560
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07443541
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07418175
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07374926
97SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.06657674
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04871821
99FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04213698
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03442643
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02872009
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.02001933
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01844098
104* BCAT_22108803_ChIP-Seq_LS180_Human0.99910434
105* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99299885
106FOXA2_19822575_ChIP-Seq_HepG2_Human0.98663808
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.98143776
108ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97186131
109MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96914970
110SMAD4_21799915_ChIP-Seq_A2780_Human0.96865193
111EED_16625203_ChIP-ChIP_MESCs_Mouse0.96529947
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95942977
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95260597
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94449468
115WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93986900
116DROSHA_22980978_ChIP-Seq_HELA_Human0.92860877
117STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91892744
118* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91715281
119* CDX2_22108803_ChIP-Seq_LS180_Human0.91548381
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91082523
121ATF3_27146783_Chip-Seq_COLON_Human0.90914983
122P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90482143
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89999670
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88879441
125BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88803200
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88437000
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88021375
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87310332
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87097049
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.86904375
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85925921
132AR_21909140_ChIP-Seq_LNCAP_Human0.84875492
133* UBF1/2_26484160_Chip-Seq_HMECs_Human0.84761820
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84516148
135POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84256077
136RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84177398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.78587037
2MP0005171_absent_coat_pigmentation6.60755512
3MP0002877_abnormal_melanocyte_morpholog4.15794373
4MP0005257_abnormal_intraocular_pressure4.09720268
5MP0005408_hypopigmentation3.73559946
6MP0010234_abnormal_vibrissa_follicle3.33449340
7MP0000371_diluted_coat_color3.30498741
8MP0003878_abnormal_ear_physiology3.27486483
9MP0005377_hearing/vestibular/ear_phenot3.27486483
10MP0003705_abnormal_hypodermis_morpholog3.11997814
11MP0003136_yellow_coat_color2.91880420
12MP0000569_abnormal_digit_pigmentation2.91706979
13MP0008438_abnormal_cutaneous_collagen2.27479214
14MP0005248_abnormal_Harderian_gland2.24102627
15MP0003300_gastrointestinal_ulcer2.08423001
16MP0010368_abnormal_lymphatic_system1.99713912
17MP0004264_abnormal_extraembryonic_tissu1.93882438
18MP0000015_abnormal_ear_pigmentation1.93441717
19MP0001324_abnormal_eye_pigmentation1.88870105
20MP0002095_abnormal_skin_pigmentation1.87609640
21MP0010352_gastrointestinal_tract_polyps1.85726035
22MP0002075_abnormal_coat/hair_pigmentati1.76289917
23MP0000751_myopathy1.73751800
24MP0005670_abnormal_white_adipose1.70370265
25MP0003566_abnormal_cell_adhesion1.67782860
26MP0005058_abnormal_lysosome_morphology1.67650568
27MP0001958_emphysema1.66159134
28MP0002108_abnormal_muscle_morphology1.62782094
29MP0010030_abnormal_orbit_morphology1.58308295
30MP0000749_muscle_degeneration1.56783787
31MP0001186_pigmentation_phenotype1.56757569
32MP0006054_spinal_hemorrhage1.55289991
33MP0005174_abnormal_tail_pigmentation1.52885787
34MP0000013_abnormal_adipose_tissue1.45772826
35MP0002102_abnormal_ear_morphology1.44300444
36MP0000767_abnormal_smooth_muscle1.43891154
37MP0004043_abnormal_pH_regulation1.43073080
38MP0001542_abnormal_bone_strength1.41006879
39MP0005595_abnormal_vascular_smooth1.40732807
40MP0005275_abnormal_skin_tensile1.39241336
41MP0003283_abnormal_digestive_organ1.39052988
42MP0000534_abnormal_ureter_morphology1.38254285
43MP0001299_abnormal_eye_distance/1.38017905
44MP0005076_abnormal_cell_differentiation1.32035756
45MP0003091_abnormal_cell_migration1.31905488
46MP0005164_abnormal_response_to1.31850630
47MP0005503_abnormal_tendon_morphology1.30609855
48MP0003453_abnormal_keratinocyte_physiol1.27656369
49MP0009384_cardiac_valve_regurgitation1.23329227
50MP0002295_abnormal_pulmonary_circulatio1.20463695
51MP0004885_abnormal_endolymph1.18397255
52MP0003868_abnormal_feces_composition1.18239094
53MP0003045_fibrosis1.18045744
54MP0001879_abnormal_lymphatic_vessel1.16752308
55MP0005165_increased_susceptibility_to1.16428854
56MP0005023_abnormal_wound_healing1.15043312
57MP0000733_abnormal_muscle_development1.14684654
58MP0003866_abnormal_defecation1.13202628
59MP0005197_abnormal_uvea_morphology1.12579559
60MP0009250_abnormal_appendicular_skeleto1.11743867
61MP0002139_abnormal_hepatobiliary_system1.10513955
62MP0003183_abnormal_peptide_metabolism1.10239523
63MP0000462_abnormal_digestive_system1.09958782
64MP0000003_abnormal_adipose_tissue1.09703333
65MP0003191_abnormal_cellular_cholesterol1.09415341
66MP0004084_abnormal_cardiac_muscle1.08229401
67MP0002090_abnormal_vision1.07854559
68MP0010307_abnormal_tumor_latency1.07700689
69MP0002089_abnormal_postnatal_growth/wei1.07458655
70MP0005623_abnormal_meninges_morphology1.03929324
71MP0004858_abnormal_nervous_system1.02338662
72MP0006138_congestive_heart_failure1.01772247
73MP0005409_darkened_coat_color0.99797992
74MP0004272_abnormal_basement_membrane0.99106454
75MP0001666_abnormal_nutrient_absorption0.97880148
76MP0005365_abnormal_bile_salt0.95650271
77MP0010386_abnormal_urinary_bladder0.95336576
78MP0000538_abnormal_urinary_bladder0.94625002
79MP0003828_pulmonary_edema0.93221869
80MP0002282_abnormal_trachea_morphology0.92406928
81MP0000537_abnormal_urethra_morphology0.91101275
82MP0005360_urolithiasis0.90853197
83MP0002896_abnormal_bone_mineralization0.90294611
84MP0002060_abnormal_skin_morphology0.89400992
85MP0008875_abnormal_xenobiotic_pharmacok0.88957665
86MP0002971_abnormal_brown_adipose0.88829320
87MP0004782_abnormal_surfactant_physiolog0.88707470
88MP0002998_abnormal_bone_remodeling0.88446493
89MP0005187_abnormal_penis_morphology0.85651475
90MP0001849_ear_inflammation0.85237442
91MP0000759_abnormal_skeletal_muscle0.84181219
92MP0009840_abnormal_foam_cell0.82829808
93MP0003941_abnormal_skin_development0.82780124
94MP0004883_abnormal_blood_vessel0.81346073
95MP0010155_abnormal_intestine_physiology0.78283727
96MP0005085_abnormal_gallbladder_physiolo0.78224591
97MP0010678_abnormal_skin_adnexa0.77136537
98MP0003279_aneurysm0.76658951
99MP0000747_muscle_weakness0.76254527
100MP0001661_extended_life_span0.75333872
101MP0001243_abnormal_dermal_layer0.75329309
102MP0004947_skin_inflammation0.74415263
103MP0002269_muscular_atrophy0.74069055
104MP0005375_adipose_tissue_phenotype0.73663632
105MP0005508_abnormal_skeleton_morphology0.73057746
106MP0009780_abnormal_chondrocyte_physiolo0.72942157
107MP0000490_abnormal_crypts_of0.72242704
108MP0002136_abnormal_kidney_physiology0.70920525
109MP0002938_white_spotting0.69871360
110MP0005620_abnormal_muscle_contractility0.69664630
111MP0003755_abnormal_palate_morphology0.68990185
112MP0003942_abnormal_urinary_system0.68566165
113MP0004381_abnormal_hair_follicle0.68268804
114MP0008775_abnormal_heart_ventricle0.67853013
115MP0008004_abnormal_stomach_pH0.67686099
116MP0005310_abnormal_salivary_gland0.67546852
117MP0002168_other_aberrant_phenotype0.65855280
118MP0003172_abnormal_lysosome_physiology0.65664403
119MP0001765_abnormal_ion_homeostasis0.64792068
120MP0000467_abnormal_esophagus_morphology0.64332408
121MP0004087_abnormal_muscle_fiber0.64207009
122MP0002133_abnormal_respiratory_system0.64099391
123MP0005388_respiratory_system_phenotype0.64099391
124MP0002138_abnormal_hepatobiliary_system0.62302682
125MP0003795_abnormal_bone_structure0.61815468
126MP0002128_abnormal_blood_circulation0.61675464
127MP0001663_abnormal_digestive_system0.61385087
128MP0005381_digestive/alimentary_phenotyp0.60235140
129MP0009053_abnormal_anal_canal0.60222486
130MP0010329_abnormal_lipoprotein_level0.60218087
131MP0000627_abnormal_mammary_gland0.59836807
132MP0000377_abnormal_hair_follicle0.59282963
133MP0001881_abnormal_mammary_gland0.58671080
134MP0009643_abnormal_urine_homeostasis0.58587421
135MP0005167_abnormal_blood-brain_barrier0.58428186
136MP0005330_cardiomyopathy0.58307208
137MP0000163_abnormal_cartilage_morphology0.57898680
138MP0003252_abnormal_bile_duct0.56595689
139MP0001293_anophthalmia0.55879354
140MP0005166_decreased_susceptibility_to0.54609527
141MP0003950_abnormal_plasma_membrane0.54041646
142MP0000367_abnormal_coat/_hair0.53265785
143MP0002177_abnormal_outer_ear0.53256673
144MP0000762_abnormal_tongue_morphology0.52822096
145MP0002115_abnormal_skeleton_extremities0.52325569
146MP0004019_abnormal_vitamin_homeostasis0.52063605
147MP0005390_skeleton_phenotype0.51841150
148MP0003385_abnormal_body_wall0.51631417
149MP0001756_abnormal_urination0.51468364
150MP0000432_abnormal_head_morphology0.50746153
151MP0002113_abnormal_skeleton_development0.50277811
152MP0003943_abnormal_hepatobiliary_system0.50145269
153MP0000477_abnormal_intestine_morphology0.48611418

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)5.28732776
2Hypoplasia of the fovea (HP:0007750)5.27636628
3Aplasia/Hypoplasia of the fovea (HP:0008060)5.27636628
4Subacute progressive viral hepatitis (HP:0006572)5.09652650
5Congenital sensorineural hearing impairment (HP:0008527)4.93765826
6Aplasia/Hypoplasia affecting the retina (HP:0008061)4.93000372
7Blue irides (HP:0000635)4.25652823
8Abnormality of the fovea (HP:0000493)4.23457129
9Ocular albinism (HP:0001107)4.11397157
10Neonatal short-limb short stature (HP:0008921)3.55266289
11Micronodular cirrhosis (HP:0001413)3.52535053
12Hypopigmentation of the fundus (HP:0007894)3.39410184
13Iris hypopigmentation (HP:0007730)3.33721274
14Bilateral sensorineural hearing impairment (HP:0008619)3.31981892
15Mitral stenosis (HP:0001718)3.27322399
16White forelock (HP:0002211)3.22397044
17Abnormality of chloride homeostasis (HP:0011422)3.15194990
18Ileus (HP:0002595)3.09973467
19Patchy hypopigmentation of hair (HP:0011365)3.05147189
20Abnormality of dentin (HP:0010299)3.01164289
21Hypoplasia of the iris (HP:0007676)2.99875985
22Hyperactive renin-angiotensin system (HP:0000841)2.99532042
23Osteolytic defects of the hand bones (HP:0009699)2.98857682
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.98857682
25Urinary glycosaminoglycan excretion (HP:0003541)2.98049148
26Mucopolysacchariduria (HP:0008155)2.98049148
27Generalized hypopigmentation (HP:0007513)2.95462335
28Abnormality of polysaccharide metabolism (HP:0011012)2.87779433
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87779433
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87779433
31Abnormality of proline metabolism (HP:0010907)2.87313090
32Hydroxyprolinuria (HP:0003080)2.87313090
33Popliteal pterygium (HP:0009756)2.83988793
34Cervical subluxation (HP:0003308)2.83337469
35Dysostosis multiplex (HP:0000943)2.82164109
36Broad metatarsal (HP:0001783)2.79532400
37Cardiovascular calcification (HP:0011915)2.74413667
38Viral hepatitis (HP:0006562)2.73457102
39Metabolic alkalosis (HP:0200114)2.70170104
40Spinal rigidity (HP:0003306)2.69278005
41Thin bony cortex (HP:0002753)2.69243236
42Aortic regurgitation (HP:0001659)2.63680834
43Spondylolisthesis (HP:0003302)2.62801707
44Type 1 muscle fiber predominance (HP:0003803)2.61868208
45Atrophic scars (HP:0001075)2.57876361
46Vertebral compression fractures (HP:0002953)2.57742276
47Premature rupture of membranes (HP:0001788)2.46197387
48Vascular tortuosity (HP:0004948)2.45949796
49Microglossia (HP:0000171)2.44068520
50Arterial tortuosity (HP:0005116)2.43283839
51Dilatation of the ascending aorta (HP:0005111)2.42447846
52Blue sclerae (HP:0000592)2.42069018
53Wrist flexion contracture (HP:0001239)2.39271353
54Albinism (HP:0001022)2.35667451
55Aortic aneurysm (HP:0004942)2.29588713
56Abnormality of the acetabulum (HP:0003170)2.26458505
57Mildly elevated creatine phosphokinase (HP:0008180)2.24794478
58Rectal prolapse (HP:0002035)2.23216154
59Bell-shaped thorax (HP:0001591)2.22768404
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22706983
61Coarse hair (HP:0002208)2.22555382
62Cupped ribs (HP:0000887)2.18721385
63Follicular hyperkeratosis (HP:0007502)2.18171614
64Hyperextensible skin (HP:0000974)2.17705314
65Pulmonary artery stenosis (HP:0004415)2.14196382
66Genu recurvatum (HP:0002816)2.13705490
67Short nail (HP:0001799)2.13665424
68Mitral valve prolapse (HP:0001634)2.11432477
69Vacuolated lymphocytes (HP:0001922)2.11381996
70Cerebral aneurysm (HP:0004944)2.11034363
71Abnormal delivery (HP:0001787)2.10567070
72Aortic valve stenosis (HP:0001650)2.09892534
73Peritonitis (HP:0002586)2.09128694
74Ankle contracture (HP:0006466)2.09040098
75Increased cerebral lipofuscin (HP:0011813)2.07870656
76Hypokalemic alkalosis (HP:0001949)2.07600907
77Osteoarthritis (HP:0002758)2.07148464
78Pterygium (HP:0001059)2.06617406
79Striae distensae (HP:0001065)2.05080605
80Flat acetabular roof (HP:0003180)2.03702411
81Hand muscle atrophy (HP:0009130)2.03140303
82Overgrowth (HP:0001548)2.00681127
83Joint laxity (HP:0001388)1.99305395
84Abnormality of complement system (HP:0005339)1.98891923
85Tibial bowing (HP:0002982)1.98637407
86Cutaneous melanoma (HP:0012056)1.95526050
87Shallow orbits (HP:0000586)1.94317210
88Enlarged penis (HP:0000040)1.94126757
89Coronal craniosynostosis (HP:0004440)1.93850413
90Protrusio acetabuli (HP:0003179)1.93138249
91Vascular calcification (HP:0004934)1.92854026
92Complement deficiency (HP:0004431)1.92210919
93Reduced subcutaneous adipose tissue (HP:0003758)1.91960330
94Elbow flexion contracture (HP:0002987)1.91744050
95Abnormality of the ischium (HP:0003174)1.89670330
96Spinal cord compression (HP:0002176)1.89650871
97Hypoplastic ischia (HP:0003175)1.89527309
98Right ventricular cardiomyopathy (HP:0011663)1.88715705
99Gowers sign (HP:0003391)1.88433350
100Abnormality of placental membranes (HP:0011409)1.87742065
101Amniotic constriction ring (HP:0009775)1.87742065
102Mitral regurgitation (HP:0001653)1.86156001
103Bowel diverticulosis (HP:0005222)1.84828643
104Milia (HP:0001056)1.83439648
105Wide anterior fontanel (HP:0000260)1.82546160
106Increased variability in muscle fiber diameter (HP:0003557)1.81896189
107Aortic dissection (HP:0002647)1.81232909
108Mesomelia (HP:0003027)1.80590403
109Freckling (HP:0001480)1.80290021
110Increased neuronal autofluorescent lipopigment (HP:0002074)1.78874424
111Alopecia of scalp (HP:0002293)1.76878775
112Interstitial pulmonary disease (HP:0006530)1.76661047
113Ovoid vertebral bodies (HP:0003300)1.76203278
114Abdominal distention (HP:0003270)1.75861366
115Delayed gross motor development (HP:0002194)1.75056187
116Limited hip movement (HP:0008800)1.74153904
117Breech presentation (HP:0001623)1.72633204
118Increased circulating renin level (HP:0000848)1.70506318
119Conjugated hyperbilirubinemia (HP:0002908)1.70469193
120Infantile muscular hypotonia (HP:0008947)1.70451479
121Bone cyst (HP:0012062)1.70216965
122Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69788100
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69141741
124Tetraparesis (HP:0002273)1.67760200
125Focal segmental glomerulosclerosis (HP:0000097)1.67164234
126Coxa vara (HP:0002812)1.67134844
127Chronic diarrhea (HP:0002028)1.66766570
128Heterochromia iridis (HP:0001100)1.66700059
129Vertebral arch anomaly (HP:0008438)1.66508260
130Rhizomelia (HP:0008905)1.66285400
131Bladder diverticulum (HP:0000015)1.65944683
132Soft skin (HP:0000977)1.65929739
133Ectopia lentis (HP:0001083)1.65686630
134Fragile skin (HP:0001030)1.64815018
135Macroorchidism (HP:0000053)1.64219436
136Hematochezia (HP:0002573)1.63074949
137Abnormality of the anterior chamber (HP:0000593)1.63019541
138Round ear (HP:0100830)1.61987550
139Progressive sensorineural hearing impairment (HP:0000408)1.61811257
140Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61156086
141Slender build (HP:0001533)1.61154756
142Abnormality of renal excretion (HP:0011036)1.61036264
143Long clavicles (HP:0000890)1.60895591
144Aplasia of the musculature (HP:0100854)1.60750493
145Hyperaldosteronism (HP:0000859)1.60743459
146Generalized amyotrophy (HP:0003700)1.60355025
147Tetany (HP:0001281)1.59680281
148Glucose intolerance (HP:0000833)1.59670025
149Distal upper limb amyotrophy (HP:0007149)1.59580760
150Upper limb amyotrophy (HP:0009129)1.59580760
151Autoimmune thrombocytopenia (HP:0001973)1.58331650
152Hypokalemia (HP:0002900)1.58034162
153Femoral bowing (HP:0002980)1.57889449
154Bladder neoplasm (HP:0009725)1.57363963
155Bladder carcinoma (HP:0002862)1.57363963
156Wormian bones (HP:0002645)1.56951559
157Abnormality of renin-angiotensin system (HP:0000847)1.55482644
158Absent frontal sinuses (HP:0002688)1.55291060
159Progressive hearing impairment (HP:0001730)1.55241571
160Abnormality of the gastric mucosa (HP:0004295)1.55055604
161Abnormality of carpal bone ossification (HP:0006257)1.54868332
162Abnormality of the distal phalanges of the toes (HP:0010182)1.54813534
163Ulnar bowing (HP:0003031)1.54389565
164Scapular winging (HP:0003691)1.54191680
165Aneurysm (HP:0002617)1.54009374
166Abnormality of the distal phalanx of the thumb (HP:0009617)1.53391969
167Natal tooth (HP:0000695)1.52515240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.47024632
2MUSK4.38718847
3MET3.88068340
4FRK3.70918691
5MYLK3.48400002
6BMX3.32297295
7LATS12.73881002
8LIMK12.39951030
9RIPK12.36423426
10MAP3K122.29464736
11LMTK22.28938739
12PKN22.26534268
13TRIB32.16794158
14SCYL22.11790969
15MARK32.10385035
16PTK61.96096832
17INSRR1.92904258
18EPHA21.92352841
19DDR21.87505770
20STK391.87154632
21PRKG21.69105561
22TESK11.58832064
23PDGFRA1.56498140
24CAMK1D1.54969930
25MAP3K31.42663902
26FER1.36375280
27ERN11.30399339
28TRPM71.25779733
29MST41.22842981
30PIK3CA1.20411788
31PTK21.20196822
32MOS1.17055264
33TTN1.16797629
34TAOK31.16395951
35NEK91.16152550
36WNK41.13101701
37STK31.11940108
38MAP3K21.11028172
39ABL21.10399824
40STK38L1.08999427
41BCR1.08414425
42EPHA31.02397654
43CAMK1G0.97291429
44NUAK10.95187848
45STK100.93702707
46ILK0.92835155
47EIF2AK30.89629301
48ROCK20.89058018
49DMPK0.88542328
50PRKD30.87887821
51LRRK20.87020486
52MAPKAPK30.85942625
53MAP3K140.83987634
54PDGFRB0.80641880
55CDC42BPA0.79178615
56WNK10.78947761
57PAK40.78190333
58SGK30.74718999
59TBK10.74509042
60NEK10.72439790
61CAMKK10.71800280
62MAPK150.68948445
63MAP3K100.68792079
64CAMK2D0.65942502
65FGFR40.65848831
66MAP3K60.65206363
67IRAK30.64179553
68MAP2K20.63594223
69LATS20.62979674
70PRKAA20.62851227
71CDK60.62285423
72STK240.61992534
73CDK120.61985796
74GSK3A0.61616927
75ADRBK10.61456965
76BLK0.61145793
77MAP3K130.60064250
78EIF2AK10.59731399
79JAK10.58540805
80CHUK0.57898227
81PAK20.57833658
82CAMK2G0.57218167
83WNK30.56821610
84FLT30.56651903
85PTK2B0.53083730
86CAMKK20.51841370
87PLK20.51156124
88PBK0.51088597
89STK380.51001455
90CSK0.50785834
91RET0.50145611
92MAP3K90.48249035
93PRKD20.48088140
94PAK60.47585352
95SIK10.44824890
96CASK0.44400846
97MARK10.44327368
98ICK0.41987658
99HIPK20.41332043
100RPS6KA40.41177714
101EEF2K0.40642816
102NTRK10.40232192
103WEE10.40004878
104PNCK0.39957041
105INSR0.39791660
106CAMK2B0.39200295
107AKT20.38893648
108AKT30.38823843
109PRKCE0.38405066
110SGK20.38334070
111ROCK10.38033656
112FGFR10.37351875
113PRKD10.37232728
114PDK20.36644667
115ACVR1B0.35991879
116ERBB30.35888676
117TNIK0.35769860
118PAK30.35766508
119MAPKAPK50.35690083
120MAP3K80.35628492
121MAP2K10.34740507
122SRC0.34427107
123FGFR30.33884839
124CDK80.33530796
125CCNB10.32756415
126TGFBR20.32246646
127MAP3K10.31620281
128OXSR10.31264948
129ABL10.31166827
130ERBB40.30949326
131CDK90.29397847
132PRKAA10.29070410
133SGK10.28977402
134EPHB10.28968036
135KSR10.28906468
136DYRK1B0.28745658
137MELK0.28313702
138PHKG10.26978199
139PHKG20.26978199
140EPHB20.26759914
141MTOR0.26756951
142IGF1R0.24519060
143TYK20.23150293
144ERBB20.22344427

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049783.14777681
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30849153
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.25384029
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14090930
5Carbohydrate digestion and absorption_Homo sapiens_hsa049732.13190817
6Sulfur metabolism_Homo sapiens_hsa009202.05495352
7Renin-angiotensin system_Homo sapiens_hsa046142.04573674
8Glycosaminoglycan degradation_Homo sapiens_hsa005311.91823287
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.87862776
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.87845482
11PPAR signaling pathway_Homo sapiens_hsa033201.83444364
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.83148234
13Protein digestion and absorption_Homo sapiens_hsa049741.82524250
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79671568
15Histidine metabolism_Homo sapiens_hsa003401.79073785
16Galactose metabolism_Homo sapiens_hsa000521.77108440
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76641922
18Complement and coagulation cascades_Homo sapiens_hsa046101.74550514
19Adherens junction_Homo sapiens_hsa045201.71361748
20Lysosome_Homo sapiens_hsa041421.68974764
21Other glycan degradation_Homo sapiens_hsa005111.68053650
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.65951533
23Dilated cardiomyopathy_Homo sapiens_hsa054141.62586229
24Phenylalanine metabolism_Homo sapiens_hsa003601.59573309
25Chemical carcinogenesis_Homo sapiens_hsa052041.58325791
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56430380
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56387439
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.51665960
29Vitamin digestion and absorption_Homo sapiens_hsa049771.50150476
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47521209
31Retinol metabolism_Homo sapiens_hsa008301.37675544
32Fatty acid degradation_Homo sapiens_hsa000711.36577830
33Fat digestion and absorption_Homo sapiens_hsa049751.34542613
34ECM-receptor interaction_Homo sapiens_hsa045121.34279612
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30342766
36Sphingolipid metabolism_Homo sapiens_hsa006001.28375851
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.27440266
38Thyroid hormone synthesis_Homo sapiens_hsa049181.24851901
39Focal adhesion_Homo sapiens_hsa045101.23011932
40Proteoglycans in cancer_Homo sapiens_hsa052051.21251816
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20876318
42Caffeine metabolism_Homo sapiens_hsa002321.20642604
43Salmonella infection_Homo sapiens_hsa051321.16979364
44Fatty acid biosynthesis_Homo sapiens_hsa000611.15661556
45Fructose and mannose metabolism_Homo sapiens_hsa000511.13899808
46Starch and sucrose metabolism_Homo sapiens_hsa005001.13713944
47Small cell lung cancer_Homo sapiens_hsa052221.13696877
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12197181
49Amoebiasis_Homo sapiens_hsa051461.09401652
50Glutathione metabolism_Homo sapiens_hsa004801.07576998
51Vibrio cholerae infection_Homo sapiens_hsa051101.04320459
52Osteoclast differentiation_Homo sapiens_hsa043801.02421739
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02296125
54Malaria_Homo sapiens_hsa051441.01694617
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00932564
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00847774
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00196108
58Arginine biosynthesis_Homo sapiens_hsa002200.99428309
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98436418
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.98271517
61Tuberculosis_Homo sapiens_hsa051520.96873940
62Bile secretion_Homo sapiens_hsa049760.95860748
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.95217665
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.94840121
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94308015
66TNF signaling pathway_Homo sapiens_hsa046680.93557770
67Melanoma_Homo sapiens_hsa052180.92018543
68Glycerolipid metabolism_Homo sapiens_hsa005610.91865831
69Arginine and proline metabolism_Homo sapiens_hsa003300.91286448
70Phagosome_Homo sapiens_hsa041450.90388025
71Type II diabetes mellitus_Homo sapiens_hsa049300.90249523
72Melanogenesis_Homo sapiens_hsa049160.89782276
73MicroRNAs in cancer_Homo sapiens_hsa052060.89691189
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88767085
75Tight junction_Homo sapiens_hsa045300.88097086
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.87995767
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87953869
78Pyruvate metabolism_Homo sapiens_hsa006200.87625682
79Chronic myeloid leukemia_Homo sapiens_hsa052200.85414603
80Tyrosine metabolism_Homo sapiens_hsa003500.84648489
81Toxoplasmosis_Homo sapiens_hsa051450.83764617
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82709175
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82246166
84Inositol phosphate metabolism_Homo sapiens_hsa005620.80269626
85Tryptophan metabolism_Homo sapiens_hsa003800.79844997
86Pancreatic secretion_Homo sapiens_hsa049720.79700611
87Leishmaniasis_Homo sapiens_hsa051400.79521452
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79054473
89Propanoate metabolism_Homo sapiens_hsa006400.78357726
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78253909
91beta-Alanine metabolism_Homo sapiens_hsa004100.77752524
92Axon guidance_Homo sapiens_hsa043600.77341755
93Bladder cancer_Homo sapiens_hsa052190.77017109
94Collecting duct acid secretion_Homo sapiens_hsa049660.76639844
95Pancreatic cancer_Homo sapiens_hsa052120.75171078
96Vitamin B6 metabolism_Homo sapiens_hsa007500.75140280
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74825531
98Fatty acid metabolism_Homo sapiens_hsa012120.73908895
99Endometrial cancer_Homo sapiens_hsa052130.72943135
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72918127
101Gastric acid secretion_Homo sapiens_hsa049710.72314842
102Pertussis_Homo sapiens_hsa051330.69405131
103HIF-1 signaling pathway_Homo sapiens_hsa040660.68350848
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68222374
105Prolactin signaling pathway_Homo sapiens_hsa049170.67213241
106Dorso-ventral axis formation_Homo sapiens_hsa043200.67008314
107Legionellosis_Homo sapiens_hsa051340.66297371
108Renal cell carcinoma_Homo sapiens_hsa052110.65944910
109Glioma_Homo sapiens_hsa052140.65636373
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64291776
111Prostate cancer_Homo sapiens_hsa052150.63410985
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.62529664
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62461794
114Prion diseases_Homo sapiens_hsa050200.62209267
115Salivary secretion_Homo sapiens_hsa049700.61735490
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61608796
117Estrogen signaling pathway_Homo sapiens_hsa049150.61443199
118mTOR signaling pathway_Homo sapiens_hsa041500.61152472
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60121853
120Gap junction_Homo sapiens_hsa045400.59965015
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59962366
122Apoptosis_Homo sapiens_hsa042100.59475316
123Rheumatoid arthritis_Homo sapiens_hsa053230.58416837
124Choline metabolism in cancer_Homo sapiens_hsa052310.58061721
125ABC transporters_Homo sapiens_hsa020100.57194821
126Shigellosis_Homo sapiens_hsa051310.57045856
127Circadian rhythm_Homo sapiens_hsa047100.56074364
128Fatty acid elongation_Homo sapiens_hsa000620.54685989
129TGF-beta signaling pathway_Homo sapiens_hsa043500.54666849
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53909629
131N-Glycan biosynthesis_Homo sapiens_hsa005100.52995794
132Insulin secretion_Homo sapiens_hsa049110.52104348
133Platelet activation_Homo sapiens_hsa046110.52054404
134Folate biosynthesis_Homo sapiens_hsa007900.51213187
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50977944
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50946004
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50272315
138Influenza A_Homo sapiens_hsa051640.49147822
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48531486
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48213790
141Nitrogen metabolism_Homo sapiens_hsa009100.48204622
142AMPK signaling pathway_Homo sapiens_hsa041520.48185474
143Hepatitis C_Homo sapiens_hsa051600.47935025
144Endocytosis_Homo sapiens_hsa041440.47833834
145Pathways in cancer_Homo sapiens_hsa052000.47322910
146FoxO signaling pathway_Homo sapiens_hsa040680.47309725
147Insulin resistance_Homo sapiens_hsa049310.47270916
148Sulfur relay system_Homo sapiens_hsa041220.46718579
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.46475201
150Hepatitis B_Homo sapiens_hsa051610.46327039
151Hippo signaling pathway_Homo sapiens_hsa043900.46246827
152Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45671325
153ErbB signaling pathway_Homo sapiens_hsa040120.45071850
154Basal cell carcinoma_Homo sapiens_hsa052170.43032280
155Renin secretion_Homo sapiens_hsa049240.41185914

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »