EPS8L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.97076737
2keratinization (GO:0031424)9.82645951
3desmosome organization (GO:0002934)9.29467483
4regulation of water loss via skin (GO:0033561)8.88815550
5mature B cell differentiation involved in immune response (GO:0002313)8.85514516
6mature B cell differentiation (GO:0002335)7.68968563
7glucosamine-containing compound catabolic process (GO:1901072)7.19638493
8germinal center formation (GO:0002467)6.53510442
9multicellular organismal water homeostasis (GO:0050891)6.22199062
10T-helper 1 type immune response (GO:0042088)5.97199351
11branching involved in labyrinthine layer morphogenesis (GO:0060670)5.64826160
12hemidesmosome assembly (GO:0031581)5.63537013
13mesenchymal cell differentiation involved in kidney development (GO:0072161)5.42617008
14mesenchymal cell differentiation involved in renal system development (GO:2001012)5.42617008
15keratinocyte differentiation (GO:0030216)5.38100938
16axonemal dynein complex assembly (GO:0070286)5.08744192
17water homeostasis (GO:0030104)5.06207440
18T-helper cell differentiation (GO:0042093)5.01446363
19CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)5.01446363
20positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.81748933
21epithelial cell-cell adhesion (GO:0090136)4.73936000
22negative regulation of interleukin-8 production (GO:0032717)4.69635869
23surfactant homeostasis (GO:0043129)4.67620074
24peptide cross-linking (GO:0018149)4.60828664
25planar cell polarity pathway involved in neural tube closure (GO:0090179)4.58285951
26immunoglobulin mediated immune response (GO:0016064)4.48022815
27regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.47049651
28response to UV-C (GO:0010225)4.35160103
29semaphorin-plexin signaling pathway (GO:0071526)4.34316701
30T cell differentiation involved in immune response (GO:0002292)4.33222790
31alpha-beta T cell differentiation involved in immune response (GO:0002293)4.33222790
32alpha-beta T cell activation involved in immune response (GO:0002287)4.33222790
33hair cycle (GO:0042633)4.24848428
34molting cycle (GO:0042303)4.24848428
35defense response to protozoan (GO:0042832)4.24352022
36epidermal cell differentiation (GO:0009913)4.21502011
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.21147037
38lung epithelium development (GO:0060428)4.19963157
39regulation of interleukin-8 biosynthetic process (GO:0045414)4.18219938
40establishment of apical/basal cell polarity (GO:0035089)4.11058641
41chemical homeostasis within a tissue (GO:0048875)4.08927962
42bundle of His cell to Purkinje myocyte communication (GO:0086069)4.06702083
43B cell mediated immunity (GO:0019724)4.05397879
44intestinal epithelial cell development (GO:0060576)4.04761128
45cell-cell junction maintenance (GO:0045217)4.04686396
46establishment of tissue polarity (GO:0007164)4.03691647
47establishment of planar polarity (GO:0001736)4.03691647
48detection of bacterium (GO:0016045)4.03022401
49response to protozoan (GO:0001562)4.00052952
50atrioventricular valve morphogenesis (GO:0003181)3.98360596
51ectoderm development (GO:0007398)3.97244769
52apical protein localization (GO:0045176)3.87176758
53motile cilium assembly (GO:0044458)3.84911771
54sphingoid metabolic process (GO:0046519)3.84314476
55keratinocyte proliferation (GO:0043616)3.82628906
56regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.81779138
57establishment of monopolar cell polarity (GO:0061162)3.76626803
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.76626803
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73620747
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73620747
61calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.68387372
62ear development (GO:0043583)3.62541508
63asymmetric protein localization (GO:0008105)3.59049519
64activation of Rac GTPase activity (GO:0032863)3.55684454
65antigen processing and presentation of endogenous antigen (GO:0019883)3.52880996
66primary alcohol catabolic process (GO:0034310)3.52097204
67keratinocyte development (GO:0003334)3.51825647
68skin morphogenesis (GO:0043589)3.50682643
69CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.48373278
70long-chain fatty acid biosynthetic process (GO:0042759)3.47108666
71detection of other organism (GO:0098543)3.45838664
72positive regulation of gamma-delta T cell activation (GO:0046645)3.45621142
73rRNA catabolic process (GO:0016075)3.44864929
74epidermis development (GO:0008544)3.42566152
75positive regulation of Cdc42 GTPase activity (GO:0043089)3.39813018
76cilium movement (GO:0003341)3.38582648
77negative regulation of stress fiber assembly (GO:0051497)3.37127089
78cell junction maintenance (GO:0034331)3.36630576
79thymic T cell selection (GO:0045061)3.35199829
80antimicrobial humoral response (GO:0019730)3.33116155
81amino sugar catabolic process (GO:0046348)3.32442037
82cilium or flagellum-dependent cell motility (GO:0001539)3.30853326
83phospholipid scrambling (GO:0017121)3.27788175
84negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.22563497
85positive thymic T cell selection (GO:0045059)3.21725021
86gland morphogenesis (GO:0022612)3.17982216
87polarized epithelial cell differentiation (GO:0030859)3.17578429
88regulation of gamma-delta T cell differentiation (GO:0045586)3.15365589
89positive regulation of epidermal cell differentiation (GO:0045606)3.15034648
90CD4-positive, alpha-beta T cell activation (GO:0035710)3.14360112
91inner cell mass cell proliferation (GO:0001833)3.11975618
92cytoskeletal anchoring at plasma membrane (GO:0007016)3.11198737
93endothelial cell chemotaxis (GO:0035767)3.10246432
94antigen processing and presentation via MHC class Ib (GO:0002475)3.09640142
95dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09609409
96alpha-beta T cell differentiation (GO:0046632)3.09236386
97Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03895238
98regulation of natural killer cell differentiation (GO:0032823)3.03260666
99negative regulation of erythrocyte differentiation (GO:0045647)3.02597811
100eyelid development in camera-type eye (GO:0061029)3.02289915
101maintenance of protein location in nucleus (GO:0051457)3.01992510
102intermediate filament organization (GO:0045109)3.01012696
103regulation of cholesterol biosynthetic process (GO:0045540)3.00912818
104regulation of cell proliferation involved in kidney development (GO:1901722)3.00345850
105embryonic camera-type eye development (GO:0031076)3.00136331
106regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.95906282
107T cell selection (GO:0045058)2.95487319
108positive regulation of interleukin-10 production (GO:0032733)2.95149464
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.94371655
110peptidyl-tyrosine autophosphorylation (GO:0038083)2.94117291
111regulation of gamma-delta T cell activation (GO:0046643)2.93326459
112alpha-beta T cell activation (GO:0046631)2.91549694
113negative regulation of cell fate specification (GO:0009996)2.90943426
114epithelial cell differentiation involved in prostate gland development (GO:0060742)2.90254733
115intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.89666233
116gap junction assembly (GO:0016264)2.89496570
117positive regulation of epidermis development (GO:0045684)2.88280662
118sphingosine metabolic process (GO:0006670)2.88160040
119regulation of establishment of planar polarity (GO:0090175)2.88001582
120face development (GO:0060324)2.85547848
121branching involved in mammary gland duct morphogenesis (GO:0060444)2.85139082
122COPI coating of Golgi vesicle (GO:0048205)2.82682330
123Golgi transport vesicle coating (GO:0048200)2.82682330
124negative regulation of keratinocyte proliferation (GO:0010839)2.81867749
125cell-cell junction assembly (GO:0007043)2.80511551
126regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80168501
127vitamin transmembrane transport (GO:0035461)2.79652585
128viral transcription (GO:0019083)2.79032582
129cell-substrate junction assembly (GO:0007044)2.78281791
130cardiac right ventricle morphogenesis (GO:0003215)2.77671874
131B cell activation involved in immune response (GO:0002312)2.76754759
132branching involved in salivary gland morphogenesis (GO:0060445)2.76707865
133establishment or maintenance of apical/basal cell polarity (GO:0035088)2.74982329
134establishment or maintenance of bipolar cell polarity (GO:0061245)2.74982329
135epithelial cilium movement (GO:0003351)2.74807526
136positive T cell selection (GO:0043368)2.73785944
137regulation of histone H3-K27 methylation (GO:0061085)2.73080657
138amyloid precursor protein metabolic process (GO:0042982)2.72911405
139regulation of hypersensitivity (GO:0002883)2.72362625
140cell differentiation involved in embryonic placenta development (GO:0060706)2.71898223
141tight junction assembly (GO:0070830)2.71249695
142* regulation of ruffle assembly (GO:1900027)2.70352778
143positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.69817182
144G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.69374595
145T cell activation involved in immune response (GO:0002286)2.68737459
146regulation of viral release from host cell (GO:1902186)2.67556058
147regulation of transforming growth factor beta1 production (GO:0032908)2.63988168
148lipoxygenase pathway (GO:0019372)2.62021888
149regulation of Cdc42 GTPase activity (GO:0043088)2.61987240
150O-glycan processing (GO:0016266)2.61409290
151ventricular cardiac muscle cell action potential (GO:0086005)2.61238157
152protein kinase C signaling (GO:0070528)2.61088306
153diterpenoid biosynthetic process (GO:0016102)2.60483342
154morphogenesis of embryonic epithelium (GO:0016331)2.59759423
155regulation of cholesterol homeostasis (GO:2000188)2.59303534
156mitochondrial calcium ion homeostasis (GO:0051560)2.58766599
157interleukin-1-mediated signaling pathway (GO:0070498)2.57922460
158megakaryocyte development (GO:0035855)2.57316483
159estrogen biosynthetic process (GO:0006703)2.56946202
160maturation of SSU-rRNA (GO:0030490)2.56551853
161positive regulation of glomerulus development (GO:0090193)2.54058844
162positive regulation of keratinocyte differentiation (GO:0045618)2.53968614
163ribosomal small subunit assembly (GO:0000028)2.53838532
164translational termination (GO:0006415)2.53721258
165negative regulation of cell size (GO:0045792)2.53638404
166ethanol metabolic process (GO:0006067)2.53462805
167diol metabolic process (GO:0034311)2.53271617
168linoleic acid metabolic process (GO:0043651)2.53215075
169maternal placenta development (GO:0001893)2.52814685
170regulation of interleukin-12 biosynthetic process (GO:0045075)2.52626120
171regulation of clathrin-mediated endocytosis (GO:2000369)2.51867777
172collecting duct development (GO:0072044)2.50184156
173negative thymic T cell selection (GO:0045060)2.49556947
174L-serine transport (GO:0015825)2.48896563
175epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.48825105
176negative regulation of actin filament bundle assembly (GO:0032232)2.48693087
177negative regulation of transcription by competitive promoter binding (GO:0010944)2.46385099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.38389416
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.42811685
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.36512367
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.33326614
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32961760
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.55554081
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.39575016
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.32926455
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.27966345
10SCL_19346495_ChIP-Seq_HPC-7_Human2.27203862
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24388011
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.20722926
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17279456
14STAT6_21828071_ChIP-Seq_BEAS2B_Human2.00976364
15TP63_17297297_ChIP-ChIP_HaCaT_Human10.4270247
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93503963
17CTCF_27219007_Chip-Seq_Bcells_Human1.85204576
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83280875
19RUNX_20019798_ChIP-Seq_JUKART_Human1.82833101
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.81704620
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80918904
22UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.72221080
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70660749
24SMC4_20622854_ChIP-Seq_HELA_Human1.69172910
25P68_20966046_ChIP-Seq_HELA_Human1.69071300
26TCF7_22412390_ChIP-Seq_EML_Mouse1.67877696
27ATF3_27146783_Chip-Seq_COLON_Human1.67777250
28CREB1_26743006_Chip-Seq_LNCaP_Human1.65336792
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65279176
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.64144317
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63606852
32ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63092917
33* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62011322
34* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62011322
35CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.57412800
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53944954
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.53155105
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51535202
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50986060
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50507021
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.50274773
42MAF_26560356_Chip-Seq_TH1_Human1.49232388
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.48080851
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.45972261
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44524007
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44038362
47KDM2B_26808549_Chip-Seq_DND41_Human1.43887180
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42093362
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.40960743
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38498546
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38258820
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38044289
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.37839505
54TCF4_18268006_ChIP-ChIP_LS174T_Human1.35746248
55GATA1_22025678_ChIP-Seq_K562_Human1.35730059
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32939230
57* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32721932
58MYB_26560356_Chip-Seq_TH2_Human1.32459664
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.31481100
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28901393
61SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28204646
62* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28105632
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28054132
64ZNF263_19887448_ChIP-Seq_K562_Human1.27574293
65LXR_22292898_ChIP-Seq_THP-1_Human1.27245713
66* UTX_26944678_Chip-Seq_JUKART_Human1.26795521
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26073702
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25883489
69KLF5_25053715_ChIP-Seq_YYC3_Human1.25141091
70AR_21572438_ChIP-Seq_LNCaP_Human1.24992796
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24658114
72RACK7_27058665_Chip-Seq_MCF-7_Human1.24031501
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23693388
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23658868
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23400589
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23142697
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22609492
78BCOR_27268052_Chip-Seq_Bcells_Human1.22209043
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21996100
80* SOX2_20726797_ChIP-Seq_SW620_Human1.21905928
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.19919331
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19745070
83TP63_23658742_ChIP-Seq_EP156T_Human1.19740610
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19526916
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19465976
86VDR_24763502_ChIP-Seq_THP-1_Human1.19013046
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17479928
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17122442
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16086292
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13673629
91AHR_22903824_ChIP-Seq_MCF-7_Human1.12991915
92E2F1_20622854_ChIP-Seq_HELA_Human1.12352698
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.12092375
94VDR_21846776_ChIP-Seq_THP-1_Human1.11854062
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.11509758
96KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11299711
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11137204
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10822781
99TP63_22573176_ChIP-Seq_HFKS_Human1.10542378
100IRF8_27001747_Chip-Seq_BMDM_Mouse1.09855490
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.09806540
102MYB_26560356_Chip-Seq_TH1_Human1.09508964
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08945737
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08611442
105GATA4_25053715_ChIP-Seq_YYC3_Human1.07868710
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07571405
107CTCF_20526341_ChIP-Seq_ESCs_Human1.07452397
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07169870
109TET1_21490601_ChIP-Seq_MESCs_Mouse1.06541864
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06286625
111TP53_22127205_ChIP-Seq_IMR90_Human1.05728769
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04976632
113BCL6_27268052_Chip-Seq_Bcells_Human1.04607604
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03767450
115* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03686321
116RARB_24833708_ChIP-Seq_LIVER_Mouse1.03096023
117SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03037277
118MYC_22102868_ChIP-Seq_BL_Human1.02732101
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01607008
120CLOCK_20551151_ChIP-Seq_293T_Human1.00919311
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00331751
122PHF8_20622854_ChIP-Seq_HELA_Human0.99959377
123SA1_27219007_Chip-Seq_Bcells_Human0.99189163
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99100359
125HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98826395
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98407302
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97542881
128GATA2_19941826_ChIP-Seq_K562_Human0.97469902
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97224216
130GATA1_19941826_ChIP-Seq_K562_Human0.97143431
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96963733
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.96619899
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96480192
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95965255
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95522622
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95011451
137PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93389571
138GATA6_25053715_ChIP-Seq_YYC3_Human0.93329337
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.93066433
140DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91810835
141YY1_22570637_ChIP-Seq_MALME-3M_Human0.91661138
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91065633
143* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90977442
144PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90434340
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.90285509
146LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89757796
147ELF1_20517297_ChIP-Seq_JURKAT_Human0.89689144
148CJUN_26792858_Chip-Seq_BT549_Human0.88265812
149P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86851325
150KDM2B_26808549_Chip-Seq_K562_Human0.86713320
151BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86684595
152NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85642393
153Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85448977
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.85408965
155TBX20_22080862_ChIP-Seq_HEART_Mouse0.84952314
156TBX20_22328084_ChIP-Seq_HEART_Mouse0.84952314
157DROSHA_22980978_ChIP-Seq_HELA_Human0.84817883

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.76587983
2MP0010234_abnormal_vibrissa_follicle5.40573051
3MP0005275_abnormal_skin_tensile4.77502346
4MP0005501_abnormal_skin_physiology4.48633634
5MP0003941_abnormal_skin_development3.13301723
6MP0004381_abnormal_hair_follicle3.13261156
7MP0004947_skin_inflammation3.10985220
8MP0002060_abnormal_skin_morphology3.05892579
9MP0004264_abnormal_extraembryonic_tissu2.98798135
10MP0002166_altered_tumor_susceptibility2.95393772
11MP0001216_abnormal_epidermal_layer2.94311805
12MP0000579_abnormal_nail_morphology2.79833490
13MP0010771_integument_phenotype2.71091437
14MP0002254_reproductive_system_inflammat2.58285484
15MP0010678_abnormal_skin_adnexa2.43243053
16MP0005451_abnormal_body_composition2.27338259
17MP0000383_abnormal_hair_follicle2.25224278
18MP0002006_tumorigenesis2.21494194
19MP0003453_abnormal_keratinocyte_physiol2.15398942
20MP0003763_abnormal_thymus_physiology2.13989482
21MP0002009_preneoplasia2.08655003
22MP0002098_abnormal_vibrissa_morphology2.02930662
23MP0000467_abnormal_esophagus_morphology1.87963456
24MP0000377_abnormal_hair_follicle1.85726189
25MP0000647_abnormal_sebaceous_gland1.83866035
26MP0010030_abnormal_orbit_morphology1.82964720
27MP0003191_abnormal_cellular_cholesterol1.82678206
28MP0009379_abnormal_foot_pigmentation1.77523963
29MP0003566_abnormal_cell_adhesion1.76918296
30MP0001191_abnormal_skin_condition1.71616663
31MP0001188_hyperpigmentation1.71607415
32MP0004782_abnormal_surfactant_physiolog1.66974274
33MP0003303_peritoneal_inflammation1.63907861
34MP0003705_abnormal_hypodermis_morpholog1.63792310
35MP0003878_abnormal_ear_physiology1.61693060
36MP0005377_hearing/vestibular/ear_phenot1.61693060
37MP0010352_gastrointestinal_tract_polyps1.61336614
38MP0002653_abnormal_ependyma_morphology1.61045885
39MP0009931_abnormal_skin_appearance1.57524597
40MP0005083_abnormal_biliary_tract1.55562219
41MP0002396_abnormal_hematopoietic_system1.54979620
42MP0001849_ear_inflammation1.53666424
43MP0004043_abnormal_pH_regulation1.52793069
44MP0001835_abnormal_antigen_presentation1.52649925
45MP0000465_gastrointestinal_hemorrhage1.44417514
46MP0001800_abnormal_humoral_immune1.42951461
47MP0002249_abnormal_larynx_morphology1.40689337
48MP0000427_abnormal_hair_cycle1.40544658
49MP0000678_abnormal_parathyroid_gland1.37128357
50MP0000685_abnormal_immune_system1.36397069
51MP0000762_abnormal_tongue_morphology1.35149810
52MP0001873_stomach_inflammation1.34340092
53MP0009780_abnormal_chondrocyte_physiolo1.34046548
54MP0002095_abnormal_skin_pigmentation1.29755524
55MP0005174_abnormal_tail_pigmentation1.27204298
56MP0008004_abnormal_stomach_pH1.22910343
57MP0008875_abnormal_xenobiotic_pharmacok1.22428087
58MP0000367_abnormal_coat/_hair1.22087298
59MP0001346_abnormal_lacrimal_gland1.22021545
60MP0003890_abnormal_embryonic-extraembry1.20068241
61MP0008789_abnormal_olfactory_epithelium1.14347647
62MP0001790_abnormal_immune_system1.14090907
63MP0005387_immune_system_phenotype1.14090907
64MP0001243_abnormal_dermal_layer1.11717450
65MP0002452_abnormal_antigen_presenting1.07668022
66MP0005499_abnormal_olfactory_system1.06304406
67MP0005394_taste/olfaction_phenotype1.06304406
68MP0002723_abnormal_immune_serum1.05523861
69MP0000566_synostosis1.02937524
70MP0008961_abnormal_basal_metabolism1.02316081
71MP0003300_gastrointestinal_ulcer1.01785073
72MP0005671_abnormal_response_to1.01530228
73MP0002420_abnormal_adaptive_immunity1.00475924
74MP0003724_increased_susceptibility_to1.00218718
75MP0004185_abnormal_adipocyte_glucose0.99445518
76MP0005000_abnormal_immune_tolerance0.98966129
77MP0004019_abnormal_vitamin_homeostasis0.98895201
78MP0005025_abnormal_response_to0.98485782
79MP0000537_abnormal_urethra_morphology0.98377942
80MP0001819_abnormal_immune_cell0.97997316
81MP0003436_decreased_susceptibility_to0.96951111
82MP0009384_cardiac_valve_regurgitation0.94697228
83MP0010155_abnormal_intestine_physiology0.93546691
84MP0001851_eye_inflammation0.93166035
85MP0005075_abnormal_melanosome_morpholog0.88188201
86MP0005464_abnormal_platelet_physiology0.87695749
87MP0001765_abnormal_ion_homeostasis0.85275502
88MP0000003_abnormal_adipose_tissue0.85265029
89MP0002822_catalepsy0.82990685
90MP0004133_heterotaxia0.82654707
91MP0002398_abnormal_bone_marrow0.81298358
92MP0001664_abnormal_digestion0.80317847
93MP0001784_abnormal_fluid_regulation0.78781700
94MP0005375_adipose_tissue_phenotype0.78446082
95MP0005076_abnormal_cell_differentiation0.77982879
96MP0005397_hematopoietic_system_phenotyp0.76712230
97MP0001545_abnormal_hematopoietic_system0.76712230
98MP0002419_abnormal_innate_immunity0.76159274
99MP0009053_abnormal_anal_canal0.76090086
100MP0001853_heart_inflammation0.75377887
101MP0003123_paternal_imprinting0.74366674
102MP0008260_abnormal_autophagy0.73553564
103MP0002722_abnormal_immune_system0.72242627
104MP0005666_abnormal_adipose_tissue0.72154092
105MP0005023_abnormal_wound_healing0.71897809
106MP0000716_abnormal_immune_system0.71300462
107MP0003448_altered_tumor_morphology0.70647284
108MP0002148_abnormal_hypersensitivity_rea0.70315939
109MP0009785_altered_susceptibility_to0.69519381
110MP0004272_abnormal_basement_membrane0.68494923
111MP0003866_abnormal_defecation0.67597952
112MP0001502_abnormal_circadian_rhythm0.66825261
113MP0005257_abnormal_intraocular_pressure0.66593988
114MP0002282_abnormal_trachea_morphology0.66375413
115MP0002111_abnormal_tail_morphology0.66266494
116MP0001958_emphysema0.64359873
117MP0000462_abnormal_digestive_system0.64307924
118MP0002089_abnormal_postnatal_growth/wei0.64045918
119MP0003942_abnormal_urinary_system0.63433504
120MP0003045_fibrosis0.62732553
121MP0002877_abnormal_melanocyte_morpholog0.61792886
122MP0002405_respiratory_system_inflammati0.61755962
123MP0004858_abnormal_nervous_system0.61588469
124MP0001340_abnormal_eyelid_morphology0.60978253
125MP0000470_abnormal_stomach_morphology0.60202360
126MP0003638_abnormal_response/metabolism_0.59224089
127MP0001845_abnormal_inflammatory_respons0.58059535
128MP0003755_abnormal_palate_morphology0.58053546
129MP0008995_early_reproductive_senescence0.56467388
130MP0005409_darkened_coat_color0.56400644
131MP0004808_abnormal_hematopoietic_stem0.55699761
132MP0000703_abnormal_thymus_morphology0.55078609
133MP0002234_abnormal_pharynx_morphology0.55000071
134MP0005248_abnormal_Harderian_gland0.54609791
135MP0000689_abnormal_spleen_morphology0.54517722
136MP0009333_abnormal_splenocyte_physiolog0.54004736
137MP0000627_abnormal_mammary_gland0.53781850
138MP0001756_abnormal_urination0.53147097
139MP0003787_abnormal_imprinting0.52380852
140MP0006054_spinal_hemorrhage0.51118767
141MP0003315_abnormal_perineum_morphology0.50895471
142MP0003011_delayed_dark_adaptation0.50298835
143MP0010307_abnormal_tumor_latency0.50256959
144MP0002429_abnormal_blood_cell0.49622830
145MP0005058_abnormal_lysosome_morphology0.49380562
146MP0002116_abnormal_craniofacial_bone0.48221207
147MP0006138_congestive_heart_failure0.46844976
148MP0003115_abnormal_respiratory_system0.46729779
149MP0003936_abnormal_reproductive_system0.46605376
150MP0004197_abnormal_fetal_growth/weight/0.46586263
151MP0002909_abnormal_adrenal_gland0.46575115
152MP0000477_abnormal_intestine_morphology0.46083616
153MP0000681_abnormal_thyroid_gland0.45792044
154MP0000534_abnormal_ureter_morphology0.45215409
155MP0001299_abnormal_eye_distance/0.43100686
156MP0002233_abnormal_nose_morphology0.40174074
157MP0001727_abnormal_embryo_implantation0.39779428
158MP0000013_abnormal_adipose_tissue0.39523158

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.82231451
2Asymmetry of the thorax (HP:0001555)6.60196997
3Aplastic anemia (HP:0001915)5.18626429
4Onycholysis (HP:0001806)4.88520145
5Natal tooth (HP:0000695)4.75699983
6Plantar hyperkeratosis (HP:0007556)4.68163282
7Chronic bronchitis (HP:0004469)4.67663047
8Hypotrichosis (HP:0001006)4.57767565
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.53007975
10Abnormality of nail color (HP:0100643)4.32641592
11Congenital ichthyosiform erythroderma (HP:0007431)4.29284933
12Right ventricular cardiomyopathy (HP:0011663)4.28364342
13Palmoplantar hyperkeratosis (HP:0000972)4.22615305
14Erythema (HP:0010783)3.99448665
15Palmar hyperkeratosis (HP:0010765)3.94286940
16Fibular aplasia (HP:0002990)3.90984603
17Woolly hair (HP:0002224)3.89734298
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.83171677
19Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.82646987
20Hyperactive renin-angiotensin system (HP:0000841)3.80103529
21Abnormal respiratory epithelium morphology (HP:0012253)3.73838019
22Abnormal respiratory motile cilium morphology (HP:0005938)3.73838019
23Advanced eruption of teeth (HP:0006288)3.71423333
24Abnormal respiratory motile cilium physiology (HP:0012261)3.67442824
25Oral leukoplakia (HP:0002745)3.66366868
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58047831
27Thoracic kyphosis (HP:0002942)3.56497689
28Milia (HP:0001056)3.54756081
29Abnormality of the lumbar spine (HP:0100712)3.41008788
30Abnormal ciliary motility (HP:0012262)3.39877405
31Lip pit (HP:0100267)3.39466874
32Erythroderma (HP:0001019)3.39404298
33Rhinitis (HP:0012384)3.36319204
34Pili torti (HP:0003777)3.35803908
35Fragile nails (HP:0001808)3.28662061
36Conjunctival hamartoma (HP:0100780)3.21614953
37Chromsome breakage (HP:0040012)3.13530344
38Ectropion (HP:0000656)3.12334935
39Gangrene (HP:0100758)3.10439713
40Dynein arm defect of respiratory motile cilia (HP:0012255)3.09917650
41Absent/shortened dynein arms (HP:0200106)3.09917650
42Corneal erosion (HP:0200020)3.02015356
43Medulloblastoma (HP:0002885)3.01097339
44Eczematoid dermatitis (HP:0000976)2.96046378
45Abnormal blistering of the skin (HP:0008066)2.95990427
46Interstitial pulmonary disease (HP:0006530)2.82253601
47Fibular hypoplasia (HP:0003038)2.74306262
48Pruritus (HP:0000989)2.71131946
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.69160786
50Acanthosis nigricans (HP:0000956)2.66884119
51Renal salt wasting (HP:0000127)2.64095538
52Anal stenosis (HP:0002025)2.62893180
53Broad ribs (HP:0000885)2.61183935
54Thick nail (HP:0001805)2.57818432
55Distal lower limb muscle weakness (HP:0009053)2.55072528
56Distal lower limb amyotrophy (HP:0008944)2.54698418
57Colon cancer (HP:0003003)2.52884881
58Cervical subluxation (HP:0003308)2.52422057
59Distal upper limb amyotrophy (HP:0007149)2.51151845
60Upper limb amyotrophy (HP:0009129)2.51151845
61Abnormality of the thoracic spine (HP:0100711)2.51082137
62Abnormality of permanent molar morphology (HP:0011071)2.49807718
63Abnormality of the dental root (HP:0006486)2.49807718
64Taurodontia (HP:0000679)2.49807718
65Bronchiectasis (HP:0002110)2.48852259
66IgM deficiency (HP:0002850)2.48154676
67Septate vagina (HP:0001153)2.47932302
68Hyporeflexia of lower limbs (HP:0002600)2.45810661
69Abnormality of the preputium (HP:0100587)2.44751377
70Obstructive sleep apnea (HP:0002870)2.42522669
71Nail dystrophy (HP:0008404)2.40573525
72Sparse scalp hair (HP:0002209)2.39265969
73Abnormal hemoglobin (HP:0011902)2.38666481
74Partial agenesis of the corpus callosum (HP:0001338)2.38060325
75Atelectasis (HP:0100750)2.37482670
76Oligodontia (HP:0000677)2.35563694
77Parakeratosis (HP:0001036)2.34369609
78Ventricular tachycardia (HP:0004756)2.33183587
79Broad face (HP:0000283)2.32348342
80Hypohidrosis (HP:0000966)2.31317350
81Delayed closure of the anterior fontanelle (HP:0001476)2.30661559
82Abnormality of the distal phalanges of the toes (HP:0010182)2.29977483
83Abnormality of molar morphology (HP:0011070)2.29015426
84Abnormality of molar (HP:0011077)2.29015426
85Mildly elevated creatine phosphokinase (HP:0008180)2.28532047
86Flat acetabular roof (HP:0003180)2.26467180
87Hypergammaglobulinemia (HP:0010702)2.26045237
88Congenital malformation of the right heart (HP:0011723)2.26013555
89Double outlet right ventricle (HP:0001719)2.26013555
90Chronic otitis media (HP:0000389)2.25297439
91Sparse eyelashes (HP:0000653)2.24624108
92Pterygium (HP:0001059)2.23881507
93Tracheomalacia (HP:0002779)2.19753002
94Thin bony cortex (HP:0002753)2.18274990
95Ridged nail (HP:0001807)2.18267791
96Nasal speech (HP:0001611)2.17278130
97Palmoplantar keratoderma (HP:0000982)2.16506748
98Abnormality of the dental pulp (HP:0006479)2.14453930
99Popliteal pterygium (HP:0009756)2.14437608
100Abnormal hair laboratory examination (HP:0003328)2.12976296
101Nephroblastoma (Wilms tumor) (HP:0002667)2.08941633
102Hyperkalemia (HP:0002153)2.08602631
103Pustule (HP:0200039)2.08587793
104Hypoplasia of dental enamel (HP:0006297)2.07672244
105Recurrent bronchitis (HP:0002837)2.07453308
106Abnormality of the salivary glands (HP:0010286)2.05067476
107Prolonged bleeding time (HP:0003010)2.04566166
108Absent eyelashes (HP:0000561)2.03614737
109Sepsis (HP:0100806)2.03304161
110Areflexia of lower limbs (HP:0002522)2.02992436
111Inflammation of the large intestine (HP:0002037)2.02279737
112Anomalous pulmonary venous return (HP:0010772)2.02057608
113Hand muscle atrophy (HP:0009130)2.01066367
114Short nail (HP:0001799)2.00735329
115Thickened calvaria (HP:0002684)1.99908658
116Male infertility (HP:0003251)1.99786279
117Skin ulcer (HP:0200042)1.99615749
118Atrophic scars (HP:0001075)1.98886233
119Amelogenesis imperfecta (HP:0000705)1.98175883
120Craniofacial hyperostosis (HP:0004493)1.96525407
121Stridor (HP:0010307)1.96013583
122Seborrheic dermatitis (HP:0001051)1.95234095
123Hyperacusis (HP:0010780)1.93930230
124Dehydration (HP:0001944)1.93735202
125Spontaneous hematomas (HP:0007420)1.93675059
126Embryonal renal neoplasm (HP:0011794)1.91369804
127Anonychia (HP:0001798)1.88698263
128Decreased circulating renin level (HP:0003351)1.87566210
129Asplenia (HP:0001746)1.86431378
130Papilloma (HP:0012740)1.85645223
131Verrucae (HP:0200043)1.85645223
132Abnormality of the neuromuscular junction (HP:0003398)1.85575226
133Fatigable weakness (HP:0003473)1.85575226
134Agammaglobulinemia (HP:0004432)1.83931636
135Hypoplastic labia majora (HP:0000059)1.83201706
136Abnormality of the nasal mucosa (HP:0000433)1.83089392
137Abnormality of the pulmonary veins (HP:0011718)1.82805767
138Infertility (HP:0000789)1.82007480
139Hypochromic anemia (HP:0001931)1.81923716
140Gastrointestinal inflammation (HP:0004386)1.81541601
141Curly hair (HP:0002212)1.81022083
142Alopecia of scalp (HP:0002293)1.80460022
143Clubbing of toes (HP:0100760)1.79457121
144Abnormality of chloride homeostasis (HP:0011422)1.79325142
145Bronchomalacia (HP:0002780)1.77880059
146Nasolacrimal duct obstruction (HP:0000579)1.77794576
147Abnormality of the axillary hair (HP:0100134)1.76329624
148Abnormality of secondary sexual hair (HP:0009888)1.76329624
149Abnormality of chromosome stability (HP:0003220)1.75215123
150Nasal polyposis (HP:0100582)1.71430772
151Focal segmental glomerulosclerosis (HP:0000097)1.68184734
152Hyperaldosteronism (HP:0000859)1.67094636
153Selective tooth agenesis (HP:0001592)1.66950877
154Abnormality of the gastric mucosa (HP:0004295)1.66788724
155Progressive sensorineural hearing impairment (HP:0000408)1.65811414
156Abnormality of the labia majora (HP:0012881)1.65650835
157Lack of skin elasticity (HP:0100679)1.65550774
158Aplasia/Hypoplasia of the spleen (HP:0010451)1.65442275
159Petechiae (HP:0000967)1.61547845
160Bronchitis (HP:0012387)1.59129148
161Malignant hyperthermia (HP:0002047)1.58752313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK33.27471044
2MAP4K13.27081225
3LMTK23.02856038
4MST43.01443192
5MET2.52729122
6BTK2.45274075
7TGFBR22.32192332
8FGFR42.26663204
9FGFR22.17268213
10IRAK32.05822704
11NME12.03322099
12MST1R1.91991419
13ICK1.82113512
14EEF2K1.81925596
15FGFR31.80144767
16TNK21.78524397
17HCK1.76997128
18MAP3K61.74174468
19STK101.73895578
20ITK1.71927743
21ERN11.71424621
22FER1.69629074
23TYK21.66232978
24LRRK21.63068134
25RPS6KB21.61493798
26SMG11.57375580
27MAP3K31.55436552
28MAP3K141.55166249
29EPHB11.54751769
30MAP3K71.54111362
31EPHA31.53303520
32HIPK21.51265840
33BLK1.51105223
34TEC1.49270730
35ZAP701.46053836
36SIK21.45394116
37TESK11.44650094
38TTN1.43730225
39MAPK151.40087377
40MAP3K131.40051082
41MATK1.34692546
42PAK41.34312489
43PTK21.32213527
44STK241.29755428
45MAP2K61.29605673
46SYK1.26542463
47IKBKE1.25812201
48CSF1R1.22904050
49CAMK1D1.21819431
50PRKCI1.20331449
51TBK11.19350349
52PRKAA21.14963792
53LCK1.13424974
54PTK61.13129630
55MAP3K101.12719702
56GSK3A1.10272450
57KIT1.09026594
58DMPK1.08203829
59JAK31.07925609
60MAP2K31.05543375
61PIK3CG1.05346312
62BMX1.03402748
63ERBB21.02651496
64RIPK40.99288368
65JAK10.97827295
66MUSK0.97788013
67TAOK30.97487927
68CAMK10.95624469
69MAP3K20.95349964
70CSK0.94028229
71RIPK10.92841160
72RPS6KA20.92771409
73MTOR0.91199600
74GRK10.89860137
75IRAK40.89417554
76CHUK0.88081262
77FES0.87139108
78TIE10.86230506
79PRKD10.85633761
80MAP3K120.84530054
81TRPM70.84390294
82CAMK1G0.83584048
83NLK0.83169595
84GRK60.80796024
85FGFR10.79724918
86IRAK20.78036545
87LATS10.75653873
88PRKD20.74818044
89MAP3K10.72900819
90LYN0.70545657
91MAPKAPK20.69389969
92CDK60.69282428
93IKBKB0.66730419
94DYRK30.65658634
95PDGFRA0.65477621
96WNK40.65219887
97LATS20.64330292
98NTRK20.63810259
99MAP2K20.62186434
100JAK20.61936226
101TAOK10.60033709
102SIK10.59761906
103PKN20.58985270
104TRIB30.58515839
105CDC42BPA0.56063271
106MAP3K110.55307241
107ILK0.54895540
108SIK30.53839578
109FYN0.53817480
110TXK0.53232044
111RPS6KA40.52948030
112PIM20.52843371
113STK390.50436669
114PRKG20.50182153
115MAPK120.47671858
116EPHA20.47466646
117PDGFRB0.46695576
118TGFBR10.45544214
119EPHB20.44547567
120CAMK40.44190829
121IRAK10.43398819
122NEK60.42882879
123NME20.40647485
124RPS6KA60.40345789
125DYRK1B0.40127942
126DDR20.39696117
127STK380.39084223
128MAP3K90.39078259
129CDK90.37948228
130MARK20.36999084
131IGF1R0.35969360
132RPS6KC10.35886685
133RPS6KL10.35886685
134NTRK10.34891420
135MAPK80.32191224
136CDK70.31817127
137CDK120.29730236
138BCR0.28828165
139PDPK10.26600680
140CAMK2G0.26551702
141SGK4940.25318206
142SGK2230.25318206
143RPS6KA10.25017199
144MAP2K40.22161765
145STK38L0.21083865
146SRC0.20917259
147MAP2K10.20443560
148KDR0.20119314
149RET0.18861896
150ARAF0.18081356
151PHKG10.17086443
152PHKG20.17086443

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.49335773
2Primary immunodeficiency_Homo sapiens_hsa053402.45380711
3Phenylalanine metabolism_Homo sapiens_hsa003602.34114339
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.21077302
5B cell receptor signaling pathway_Homo sapiens_hsa046622.12056220
6Histidine metabolism_Homo sapiens_hsa003402.07564592
7Axon guidance_Homo sapiens_hsa043602.05985144
8Sphingolipid metabolism_Homo sapiens_hsa006001.90073739
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85280494
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84675462
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.79651329
12Ovarian steroidogenesis_Homo sapiens_hsa049131.78101205
13Hematopoietic cell lineage_Homo sapiens_hsa046401.65277624
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.61661232
15T cell receptor signaling pathway_Homo sapiens_hsa046601.61321669
16Platelet activation_Homo sapiens_hsa046111.56523183
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.56192517
18Osteoclast differentiation_Homo sapiens_hsa043801.52967297
19Acute myeloid leukemia_Homo sapiens_hsa052211.50487703
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49950833
21Leishmaniasis_Homo sapiens_hsa051401.46782711
22TNF signaling pathway_Homo sapiens_hsa046681.46013202
23Pertussis_Homo sapiens_hsa051331.43536741
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.42922075
25Tyrosine metabolism_Homo sapiens_hsa003501.42712947
26ABC transporters_Homo sapiens_hsa020101.41348415
27Toxoplasmosis_Homo sapiens_hsa051451.39380573
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.38957891
29Steroid biosynthesis_Homo sapiens_hsa001001.36727737
30Fructose and mannose metabolism_Homo sapiens_hsa000511.33291977
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.32195633
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.29988138
33Hippo signaling pathway_Homo sapiens_hsa043901.29124046
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28564701
35VEGF signaling pathway_Homo sapiens_hsa043701.28024329
36Fatty acid biosynthesis_Homo sapiens_hsa000611.27923814
37Other glycan degradation_Homo sapiens_hsa005111.25147081
38Insulin signaling pathway_Homo sapiens_hsa049101.24545986
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22635972
40Malaria_Homo sapiens_hsa051441.21810046
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20744730
42Choline metabolism in cancer_Homo sapiens_hsa052311.20481720
43Phototransduction_Homo sapiens_hsa047441.20412365
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19782287
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19183648
46Gastric acid secretion_Homo sapiens_hsa049711.17102928
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15533406
48AMPK signaling pathway_Homo sapiens_hsa041521.13926840
49Vibrio cholerae infection_Homo sapiens_hsa051101.12297548
50Ribosome_Homo sapiens_hsa030101.09040885
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07682934
52Endometrial cancer_Homo sapiens_hsa052131.07625365
53Measles_Homo sapiens_hsa051621.07537204
54Basal cell carcinoma_Homo sapiens_hsa052171.06294826
55Proteoglycans in cancer_Homo sapiens_hsa052051.05434459
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.04325422
57Hepatitis C_Homo sapiens_hsa051601.04005060
58Renin secretion_Homo sapiens_hsa049241.03463923
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03215578
60Sphingolipid signaling pathway_Homo sapiens_hsa040711.02391019
61Chemical carcinogenesis_Homo sapiens_hsa052041.01494711
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99615145
63Small cell lung cancer_Homo sapiens_hsa052220.99264242
64Chemokine signaling pathway_Homo sapiens_hsa040620.99087962
65Sulfur relay system_Homo sapiens_hsa041220.97210987
66Chronic myeloid leukemia_Homo sapiens_hsa052200.96165225
67Non-small cell lung cancer_Homo sapiens_hsa052230.96051589
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95951792
69Staphylococcus aureus infection_Homo sapiens_hsa051500.95791055
70Adherens junction_Homo sapiens_hsa045200.95068651
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94896495
72Tuberculosis_Homo sapiens_hsa051520.94155195
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93127419
74Inositol phosphate metabolism_Homo sapiens_hsa005620.92509104
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92120447
76Antigen processing and presentation_Homo sapiens_hsa046120.92018725
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.92014344
78GnRH signaling pathway_Homo sapiens_hsa049120.91932114
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91193798
80MicroRNAs in cancer_Homo sapiens_hsa052060.91061749
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.88085787
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87890048
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87589740
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87298768
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.86824454
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85500838
87Amoebiasis_Homo sapiens_hsa051460.85484352
88Galactose metabolism_Homo sapiens_hsa000520.85470550
89Estrogen signaling pathway_Homo sapiens_hsa049150.84972664
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84723663
91Salivary secretion_Homo sapiens_hsa049700.84527498
92Retinol metabolism_Homo sapiens_hsa008300.83626974
93Melanogenesis_Homo sapiens_hsa049160.82441860
94Arachidonic acid metabolism_Homo sapiens_hsa005900.81827480
95Focal adhesion_Homo sapiens_hsa045100.81605132
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80131575
97Rap1 signaling pathway_Homo sapiens_hsa040150.79592017
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.79275625
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78599229
100ECM-receptor interaction_Homo sapiens_hsa045120.78205636
101Circadian rhythm_Homo sapiens_hsa047100.77622954
102Oxytocin signaling pathway_Homo sapiens_hsa049210.76873729
103Pancreatic secretion_Homo sapiens_hsa049720.76653990
104Apoptosis_Homo sapiens_hsa042100.76485077
105Glutathione metabolism_Homo sapiens_hsa004800.75362569
106Influenza A_Homo sapiens_hsa051640.74914569
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74751847
108Ras signaling pathway_Homo sapiens_hsa040140.74668776
109Pancreatic cancer_Homo sapiens_hsa052120.73390463
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72702457
111Linoleic acid metabolism_Homo sapiens_hsa005910.71841842
112Salmonella infection_Homo sapiens_hsa051320.71475025
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70762076
114Herpes simplex infection_Homo sapiens_hsa051680.70530130
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.70159331
116Insulin resistance_Homo sapiens_hsa049310.70065345
117Renal cell carcinoma_Homo sapiens_hsa052110.69970345
118Notch signaling pathway_Homo sapiens_hsa043300.69742340
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67510667
120Pathways in cancer_Homo sapiens_hsa052000.66446910
121Prolactin signaling pathway_Homo sapiens_hsa049170.66165694
122Olfactory transduction_Homo sapiens_hsa047400.64972373
123Collecting duct acid secretion_Homo sapiens_hsa049660.64130282
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63919166
125Hedgehog signaling pathway_Homo sapiens_hsa043400.63516714
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63482258
127Tight junction_Homo sapiens_hsa045300.63366632
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63097599
129Hepatitis B_Homo sapiens_hsa051610.62545218
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62422582
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.62173205
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61529509
133mTOR signaling pathway_Homo sapiens_hsa041500.61064552
134MAPK signaling pathway_Homo sapiens_hsa040100.60925194
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60105206
136Thyroid cancer_Homo sapiens_hsa052160.59021420
137ErbB signaling pathway_Homo sapiens_hsa040120.58046266
138Calcium signaling pathway_Homo sapiens_hsa040200.57936603
139FoxO signaling pathway_Homo sapiens_hsa040680.57599740
140Bladder cancer_Homo sapiens_hsa052190.57532639
141Long-term depression_Homo sapiens_hsa047300.56664244
142Starch and sucrose metabolism_Homo sapiens_hsa005000.56440226
143Bile secretion_Homo sapiens_hsa049760.56347332
144Endocytosis_Homo sapiens_hsa041440.56131987
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53403224
146Glucagon signaling pathway_Homo sapiens_hsa049220.52944881
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50421784
148Graft-versus-host disease_Homo sapiens_hsa053320.50401375
149Ether lipid metabolism_Homo sapiens_hsa005650.49987008
150Thyroid hormone synthesis_Homo sapiens_hsa049180.49381958
151Shigellosis_Homo sapiens_hsa051310.48977048
152beta-Alanine metabolism_Homo sapiens_hsa004100.44992424
153PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42869928

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