EPS8L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.09767776
2L-phenylalanine catabolic process (GO:0006559)5.66509482
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.66509482
4L-phenylalanine metabolic process (GO:0006558)5.52552485
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.52552485
6intestinal cholesterol absorption (GO:0030299)5.41330417
7hemidesmosome assembly (GO:0031581)5.20045204
8cysteine metabolic process (GO:0006534)5.08875929
9aromatic amino acid family catabolic process (GO:0009074)4.97336610
10intestinal absorption (GO:0050892)4.96597643
11sulfur amino acid catabolic process (GO:0000098)4.91222657
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.72516877
13glyoxylate metabolic process (GO:0046487)4.66301254
14regulation of cholesterol homeostasis (GO:2000188)4.60904607
15homocysteine metabolic process (GO:0050667)4.59405981
16tryptophan catabolic process (GO:0006569)4.53439956
17indole-containing compound catabolic process (GO:0042436)4.53439956
18indolalkylamine catabolic process (GO:0046218)4.53439956
19drug catabolic process (GO:0042737)4.50885647
20kynurenine metabolic process (GO:0070189)4.42773431
21lysine metabolic process (GO:0006553)4.40132808
22lysine catabolic process (GO:0006554)4.40132808
23drug transmembrane transport (GO:0006855)4.38225265
24urea metabolic process (GO:0019627)4.32580415
25urea cycle (GO:0000050)4.32580415
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28791914
27tryptophan metabolic process (GO:0006568)4.28431783
28high-density lipoprotein particle remodeling (GO:0034375)4.18869928
29regulation of bile acid biosynthetic process (GO:0070857)4.16428173
30bile acid biosynthetic process (GO:0006699)4.11566360
31regulation of triglyceride catabolic process (GO:0010896)4.04449721
32urate metabolic process (GO:0046415)4.03415891
33phospholipid efflux (GO:0033700)4.00733012
34alpha-linolenic acid metabolic process (GO:0036109)3.96444840
35negative regulation of sterol transport (GO:0032372)3.94286063
36negative regulation of cholesterol transport (GO:0032375)3.94286063
37nitrogen cycle metabolic process (GO:0071941)3.93869938
38amino-acid betaine metabolic process (GO:0006577)3.93120308
39bile acid and bile salt transport (GO:0015721)3.92699023
40flavonoid metabolic process (GO:0009812)3.90603685
41reverse cholesterol transport (GO:0043691)3.90503307
42cellular glucuronidation (GO:0052695)3.83143791
43regulation of cholesterol esterification (GO:0010872)3.83110483
44regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79764888
45COPI coating of Golgi vesicle (GO:0048205)3.79537932
46Golgi transport vesicle coating (GO:0048200)3.79537932
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.79380887
48serine family amino acid catabolic process (GO:0009071)3.78145994
49bile acid metabolic process (GO:0008206)3.77515187
50cellular modified amino acid catabolic process (GO:0042219)3.77099684
51acylglycerol homeostasis (GO:0055090)3.74203728
52triglyceride homeostasis (GO:0070328)3.74203728
53epithelial cell-cell adhesion (GO:0090136)3.74000629
54drug transport (GO:0015893)3.73816045
55proline metabolic process (GO:0006560)3.69884010
56exogenous drug catabolic process (GO:0042738)3.67849562
57peptidyl-glutamic acid carboxylation (GO:0017187)3.66917129
58protein carboxylation (GO:0018214)3.66917129
59regulation of protein activation cascade (GO:2000257)3.64650053
60negative regulation of fibrinolysis (GO:0051918)3.62955845
61regulation of cholesterol biosynthetic process (GO:0045540)3.62228828
62proline biosynthetic process (GO:0006561)3.60966550
63aromatic amino acid family metabolic process (GO:0009072)3.59364349
64protein-lipid complex remodeling (GO:0034368)3.57937351
65macromolecular complex remodeling (GO:0034367)3.57937351
66plasma lipoprotein particle remodeling (GO:0034369)3.57937351
67complement activation, alternative pathway (GO:0006957)3.57875686
68lipoprotein metabolic process (GO:0042157)3.56772351
69cholesterol homeostasis (GO:0042632)3.56081022
70sterol homeostasis (GO:0055092)3.53910102
71imidazole-containing compound metabolic process (GO:0052803)3.53636077
72regulation of water loss via skin (GO:0033561)3.51907480
73positive regulation of triglyceride lipase activity (GO:0061365)3.50747274
74positive regulation of lipoprotein lipase activity (GO:0051006)3.50747274
75plasma lipoprotein particle assembly (GO:0034377)3.47469873
76multicellular organismal water homeostasis (GO:0050891)3.47128623
77glucuronate metabolic process (GO:0019585)3.47094202
78uronic acid metabolic process (GO:0006063)3.47094202
79epoxygenase P450 pathway (GO:0019373)3.46180885
80cholesterol efflux (GO:0033344)3.45666579
81regulation of complement activation (GO:0030449)3.44585587
82glutamate metabolic process (GO:0006536)3.43260180
83phospholipid homeostasis (GO:0055091)3.42417983
84alpha-amino acid catabolic process (GO:1901606)3.40840838
85regulation of fibrinolysis (GO:0051917)3.39447382
86regulation of cholesterol metabolic process (GO:0090181)3.39043803
87lung epithelium development (GO:0060428)3.36460963
88angiotensin maturation (GO:0002003)3.35097073
89hormone catabolic process (GO:0042447)3.32378558
90cellular amino acid catabolic process (GO:0009063)3.32186383
91activation of Rac GTPase activity (GO:0032863)3.30890239
92protein retention in ER lumen (GO:0006621)3.29101056
93short-chain fatty acid metabolic process (GO:0046459)3.28982729
94positive regulation of Cdc42 GTPase activity (GO:0043089)3.27221361
95serine family amino acid metabolic process (GO:0009069)3.26672251
96drug metabolic process (GO:0017144)3.25305875
97protein-lipid complex assembly (GO:0065005)3.24504981
98establishment of skin barrier (GO:0061436)3.24277518
99ethanol oxidation (GO:0006069)3.23549697
100plasma lipoprotein particle clearance (GO:0034381)3.23193476
101fatty acid beta-oxidation (GO:0006635)3.22171668
102benzene-containing compound metabolic process (GO:0042537)3.21047493
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20391631
104fatty acid oxidation (GO:0019395)3.19190956
105cellular ketone body metabolic process (GO:0046950)3.18054046
106indolalkylamine metabolic process (GO:0006586)3.17413548
107cell-substrate junction assembly (GO:0007044)3.17192210
108regulation of apoptotic cell clearance (GO:2000425)3.16253022
109tyrosine metabolic process (GO:0006570)3.14654839
110regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13010884
111peptide catabolic process (GO:0043171)3.12981146
112very-low-density lipoprotein particle assembly (GO:0034379)3.11882016
113lipid oxidation (GO:0034440)3.11488861
114semaphorin-plexin signaling pathway (GO:0071526)3.10599143
115cell-cell junction maintenance (GO:0045217)3.09683994
116positive regulation of fatty acid biosynthetic process (GO:0045723)3.08546374
117response to nitrosative stress (GO:0051409)3.07097905
118NADH metabolic process (GO:0006734)3.06704161
119fatty acid catabolic process (GO:0009062)3.04165011
120glutamine family amino acid biosynthetic process (GO:0009084)3.03892737
121response to mercury ion (GO:0046689)3.02920225
122branching involved in mammary gland duct morphogenesis (GO:0060444)3.01921004
123positive regulation of triglyceride metabolic process (GO:0090208)3.01493058
124organic acid catabolic process (GO:0016054)3.00807453
125carboxylic acid catabolic process (GO:0046395)3.00807453
126renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.00794483
127carnitine metabolic process (GO:0009437)3.00044190
128negative regulation of fatty acid transport (GO:2000192)2.99035776
129regulation of extracellular matrix disassembly (GO:0010715)2.98792106
130ethanol metabolic process (GO:0006067)2.97915134
131aspartate family amino acid catabolic process (GO:0009068)2.97372921
132basement membrane organization (GO:0071711)2.87026151
133water homeostasis (GO:0030104)2.80698713
134GDP-mannose metabolic process (GO:0019673)2.79140434
135gap junction assembly (GO:0016264)2.79068922
136glucose 6-phosphate metabolic process (GO:0051156)2.78579578
137surfactant homeostasis (GO:0043129)2.78460583
138renal system process involved in regulation of blood volume (GO:0001977)2.78407418
139primary alcohol catabolic process (GO:0034310)2.78192714
140cytoskeletal anchoring at plasma membrane (GO:0007016)2.75271246
141actin filament depolymerization (GO:0030042)2.74069075
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73326503
143regulation of plasminogen activation (GO:0010755)2.70672137
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.70569743
145plasma lipoprotein particle organization (GO:0071827)2.70560941
146vitamin transmembrane transport (GO:0035461)2.68854373
147regulation of extracellular matrix organization (GO:1903053)2.67352177
148calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66883033
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66443550
150fructose metabolic process (GO:0006000)2.65345057
151diacylglycerol metabolic process (GO:0046339)2.64372642
152establishment of apical/basal cell polarity (GO:0035089)2.63816502
153positive regulation of lipid catabolic process (GO:0050996)2.61974881
154cell junction maintenance (GO:0034331)2.61920815
155atrioventricular valve morphogenesis (GO:0003181)2.60930601
156phosphate ion transmembrane transport (GO:0035435)2.60541384
157negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.60258054
1584-hydroxyproline metabolic process (GO:0019471)2.59990163
159protein-lipid complex subunit organization (GO:0071825)2.58949057
160cell-substrate adherens junction assembly (GO:0007045)2.55447838
161focal adhesion assembly (GO:0048041)2.55447838
162glutathione biosynthetic process (GO:0006750)2.55150213
163positive regulation of cellular amine metabolic process (GO:0033240)2.54894956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.12217368
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.98230028
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47252076
4TP63_17297297_ChIP-ChIP_HaCaT_Human5.36712617
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.84895392
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.18452988
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89226639
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51694127
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18701436
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.05222633
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50827146
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.44524680
13* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.44200215
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30174759
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.27050731
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.24215180
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21378419
18CLOCK_20551151_ChIP-Seq_293T_Human2.17474274
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.05985039
20GATA4_25053715_ChIP-Seq_YYC3_Human2.05551174
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90674503
22* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.88412825
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.87874100
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78697423
25GATA6_25053715_ChIP-Seq_YYC3_Human1.76607532
26GATA1_22025678_ChIP-Seq_K562_Human1.74250641
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.65978187
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63985324
29* SOX2_20726797_ChIP-Seq_SW620_Human1.63727620
30UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61253647
31FOXA2_19822575_ChIP-Seq_HepG2_Human1.61149278
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55680171
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55288652
34* FOXO3_23340844_ChIP-Seq_DLD1_Human1.50631657
35ZNF263_19887448_ChIP-Seq_K562_Human1.45406769
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42843918
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42272047
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.41642827
39* KDM2B_26808549_Chip-Seq_K562_Human1.40379160
40P68_20966046_ChIP-Seq_HELA_Human1.40306715
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.39428670
42* RACK7_27058665_Chip-Seq_MCF-7_Human1.38227043
43* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37779880
44SMC4_20622854_ChIP-Seq_HELA_Human1.37666158
45KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37341438
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33954261
47* TP53_22127205_ChIP-Seq_IMR90_Human1.32153598
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30195910
49TCF7_22412390_ChIP-Seq_EML_Mouse1.28915277
50* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28591171
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27337371
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27258392
53* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27163568
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26481963
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25512546
56CTCF_27219007_Chip-Seq_Bcells_Human1.25298949
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25104425
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24396167
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.22475900
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22253947
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.21103210
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19863871
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18307274
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17518044
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17330149
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16337565
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16083599
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15308181
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15230819
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15118106
71ATF3_27146783_Chip-Seq_COLON_Human1.15004788
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14994591
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14676741
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14334853
75VDR_21846776_ChIP-Seq_THP-1_Human1.14219315
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.13014922
77* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12675819
78* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11928025
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.11925383
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10666561
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10487070
82* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09120739
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.07216073
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07188926
85KDM2B_26808549_Chip-Seq_DND41_Human1.05748942
86LXR_22292898_ChIP-Seq_THP-1_Human1.04290797
87GATA3_24758297_ChIP-Seq_MCF-7_Human1.03491562
88HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02356666
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02335365
90* BCOR_27268052_Chip-Seq_Bcells_Human1.01836239
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01447291
92RARB_24833708_ChIP-Seq_LIVER_Mouse0.99505567
93* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99249273
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97835310
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97501085
96* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96415535
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95702565
98SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95623464
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92509699
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89440936
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87086371
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87086371
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85140940
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84080474
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82987820
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82008037
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81313413
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79203684
109* CREB1_26743006_Chip-Seq_LNCaP_Human0.78384680
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.77752140
111* FOXA1_25552417_ChIP-Seq_VCAP_Human0.76236447
112EGR1_19032775_ChIP-ChIP_M12_Human0.75983704
113RXRA_24833708_ChIP-Seq_LIVER_Mouse0.75737202
114GATA2_19941826_ChIP-Seq_K562_Human0.74404502
115* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74012830
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72664079
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72415063
118TP63_22573176_ChIP-Seq_HFKS_Human0.71926251
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71352321
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.70781321
121* KLF5_25053715_ChIP-Seq_YYC3_Human0.70035952
122* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69187540
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.69122014
124RARA_24833708_ChIP-Seq_LIVER_Mouse0.68878928
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.68851775
126AR_21909140_ChIP-Seq_LNCAP_Human0.68343889
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.68113944
128TP63_23658742_ChIP-Seq_EP156T_Human0.67054436
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.65803867
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.64441395
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.64441395
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63696534
133GATA1_19941826_ChIP-Seq_K562_Human0.63243778
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62350731
135* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.62167811
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61960003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.09880860
2MP0002139_abnormal_hepatobiliary_system6.25817827
3MP0005085_abnormal_gallbladder_physiolo4.88775616
4MP0005365_abnormal_bile_salt4.58873709
5MP0008875_abnormal_xenobiotic_pharmacok3.90898431
6MP0001666_abnormal_nutrient_absorption3.70677576
7MP0003252_abnormal_bile_duct3.63747457
8MP0010234_abnormal_vibrissa_follicle3.05473369
9MP0003806_abnormal_nucleotide_metabolis2.95116652
10MP0009840_abnormal_foam_cell2.76636800
11MP0010329_abnormal_lipoprotein_level2.75170584
12MP0004019_abnormal_vitamin_homeostasis2.69996980
13MP0004264_abnormal_extraembryonic_tissu2.69963917
14MP0005409_darkened_coat_color2.65011213
15MP0002138_abnormal_hepatobiliary_system2.57119587
16MP0005332_abnormal_amino_acid2.49745029
17MP0005083_abnormal_biliary_tract2.32058401
18MP0003195_calcinosis2.31562239
19MP0002796_impaired_skin_barrier2.07505508
20MP0003705_abnormal_hypodermis_morpholog2.02995376
21MP0003191_abnormal_cellular_cholesterol2.01715843
22MP0009643_abnormal_urine_homeostasis1.91605498
23MP0002254_reproductive_system_inflammat1.91526121
24MP0005257_abnormal_intraocular_pressure1.89496925
25MP0000678_abnormal_parathyroid_gland1.83281594
26MP0005076_abnormal_cell_differentiation1.80829377
27MP0004043_abnormal_pH_regulation1.73948229
28MP0002118_abnormal_lipid_homeostasis1.62393159
29MP0000609_abnormal_liver_physiology1.61656401
30MP0003868_abnormal_feces_composition1.59547960
31MP0004858_abnormal_nervous_system1.58916049
32MP0005058_abnormal_lysosome_morphology1.56779893
33MP0002089_abnormal_postnatal_growth/wei1.46083396
34MP0005084_abnormal_gallbladder_morpholo1.42029207
35MP0000762_abnormal_tongue_morphology1.40785256
36MP0005319_abnormal_enzyme/_coenzyme1.39852173
37MP0003300_gastrointestinal_ulcer1.38260957
38MP0000003_abnormal_adipose_tissue1.34449227
39MP0001756_abnormal_urination1.33973806
40MP0009379_abnormal_foot_pigmentation1.32365288
41MP0005636_abnormal_mineral_homeostasis1.32186022
42MP0008438_abnormal_cutaneous_collagen1.28252853
43MP0000462_abnormal_digestive_system1.26490623
44MP0000013_abnormal_adipose_tissue1.22339430
45MP0005501_abnormal_skin_physiology1.22015575
46MP0002249_abnormal_larynx_morphology1.18718558
47MP0002098_abnormal_vibrissa_morphology1.17221037
48MP0001765_abnormal_ion_homeostasis1.16378433
49MP0003879_abnormal_hair_cell1.15714311
50MP0001764_abnormal_homeostasis1.15168100
51MP0005220_abnormal_exocrine_pancreas1.12833685
52MP0002136_abnormal_kidney_physiology1.05996805
53MP0003453_abnormal_keratinocyte_physiol1.04186529
54MP0000538_abnormal_urinary_bladder1.02339128
55MP0005451_abnormal_body_composition1.01166301
56MP0005584_abnormal_enzyme/coenzyme_acti0.99206652
57MP0005375_adipose_tissue_phenotype0.99187251
58MP0008260_abnormal_autophagy0.99064229
59MP0002876_abnormal_thyroid_physiology0.97154928
60MP0010678_abnormal_skin_adnexa0.97108716
61MP0000579_abnormal_nail_morphology0.96773641
62MP0002060_abnormal_skin_morphology0.96676011
63MP0004185_abnormal_adipocyte_glucose0.96562952
64MP0003283_abnormal_digestive_organ0.89783018
65MP0003091_abnormal_cell_migration0.88760518
66MP0000858_altered_metastatic_potential0.88543216
67MP0009931_abnormal_skin_appearance0.87877208
68MP0001216_abnormal_epidermal_layer0.87593605
69MP0009384_cardiac_valve_regurgitation0.87490916
70MP0010030_abnormal_orbit_morphology0.84650323
71MP0001958_emphysema0.84361760
72MP0000537_abnormal_urethra_morphology0.84314992
73MP0000598_abnormal_liver_morphology0.84279144
74MP0006054_spinal_hemorrhage0.82833849
75MP0001348_abnormal_lacrimal_gland0.82686125
76MP0003566_abnormal_cell_adhesion0.82065418
77MP0000467_abnormal_esophagus_morphology0.80713734
78MP0003866_abnormal_defecation0.79409453
79MP0003123_paternal_imprinting0.79379367
80MP0010352_gastrointestinal_tract_polyps0.79126467
81MP0009053_abnormal_anal_canal0.78783773
82MP0005408_hypopigmentation0.77483268
83MP0003183_abnormal_peptide_metabolism0.76529723
84MP0000627_abnormal_mammary_gland0.76331709
85MP0003186_abnormal_redox_activity0.75078436
86MP0001664_abnormal_digestion0.73882849
87MP0003172_abnormal_lysosome_physiology0.73817783
88MP0000377_abnormal_hair_follicle0.72190270
89MP0004947_skin_inflammation0.72060679
90MP0005275_abnormal_skin_tensile0.71412387
91MP0004782_abnormal_surfactant_physiolog0.71054161
92MP0009642_abnormal_blood_homeostasis0.70737979
93MP0006138_congestive_heart_failure0.70242952
94MP0005381_digestive/alimentary_phenotyp0.69997009
95MP0000477_abnormal_intestine_morphology0.68716430
96MP0002078_abnormal_glucose_homeostasis0.67267344
97MP0005377_hearing/vestibular/ear_phenot0.66243509
98MP0003878_abnormal_ear_physiology0.66243509
99MP0001663_abnormal_digestive_system0.65980767
100MP0003638_abnormal_response/metabolism_0.65969979
101MP0001849_ear_inflammation0.65515510
102MP0009780_abnormal_chondrocyte_physiolo0.64891668
103MP0003011_delayed_dark_adaptation0.64473147
104MP0010155_abnormal_intestine_physiology0.64402138
105MP0009764_decreased_sensitivity_to0.63888635
106MP0003115_abnormal_respiratory_system0.62882346
107MP0000534_abnormal_ureter_morphology0.62824105
108MP0002928_abnormal_bile_duct0.62751873
109MP0001873_stomach_inflammation0.60521700
110MP0000367_abnormal_coat/_hair0.60491071
111MP0005023_abnormal_wound_healing0.60133188
112MP0002896_abnormal_bone_mineralization0.59053292
113MP0008004_abnormal_stomach_pH0.58425774
114MP0004272_abnormal_basement_membrane0.58070082
115MP0002877_abnormal_melanocyte_morpholog0.56708766
116MP0005448_abnormal_energy_balance0.55904941
117MP0010368_abnormal_lymphatic_system0.55624360
118MP0010771_integument_phenotype0.55559080
119MP0005666_abnormal_adipose_tissue0.55013639
120MP0001944_abnormal_pancreas_morphology0.53774960
121MP0003941_abnormal_skin_development0.53321262
122MP0000566_synostosis0.52919110
123MP0005376_homeostasis/metabolism_phenot0.52482541
124MP0001881_abnormal_mammary_gland0.52471271
125MP0008469_abnormal_protein_level0.52296320
126MP0005670_abnormal_white_adipose0.50357512
127MP0002971_abnormal_brown_adipose0.49838927
128MP0000427_abnormal_hair_cycle0.49812057
129MP0000383_abnormal_hair_follicle0.49753050
130MP0009765_abnormal_xenobiotic_induced0.49507986

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.65500023
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.06615629
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.05957477
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01343834
5Xanthomatosis (HP:0000991)4.84937301
6Hypobetalipoproteinemia (HP:0003563)4.74276849
7Deep venous thrombosis (HP:0002625)4.44777472
8Hyperglycinuria (HP:0003108)4.18746884
9Gout (HP:0001997)4.11626613
10Right ventricular cardiomyopathy (HP:0011663)4.02040319
11Fat malabsorption (HP:0002630)3.81157589
12Hypoglycemic coma (HP:0001325)3.80057863
13Abnormality of serine family amino acid metabolism (HP:0010894)3.66380942
14Abnormality of glycine metabolism (HP:0010895)3.66380942
15Hyperammonemia (HP:0001987)3.64661203
16Hypolipoproteinemia (HP:0010981)3.60158099
17Malnutrition (HP:0004395)3.57911821
18Conjugated hyperbilirubinemia (HP:0002908)3.56906383
19Hyperactive renin-angiotensin system (HP:0000841)3.56133526
20Abnormality of purine metabolism (HP:0004352)3.52609700
21Ketosis (HP:0001946)3.49243769
22Hemorrhage of the eye (HP:0011885)3.45152566
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.43302537
24Prolonged partial thromboplastin time (HP:0003645)3.43159070
25Epidermoid cyst (HP:0200040)3.34088905
26Abnormality of aspartate family amino acid metabolism (HP:0010899)3.28926421
27Hydroxyprolinuria (HP:0003080)3.28781886
28Abnormality of proline metabolism (HP:0010907)3.28781886
29Ketoacidosis (HP:0001993)3.28225924
30Complement deficiency (HP:0004431)3.24538456
31Hyperglycinemia (HP:0002154)3.21533438
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.11568715
33Alopecia of scalp (HP:0002293)3.08228094
34Abnormality of nucleobase metabolism (HP:0010932)3.08226291
35Ileus (HP:0002595)3.04453982
36Milia (HP:0001056)3.03800661
37Thin bony cortex (HP:0002753)3.01764385
38Abnormality of the common coagulation pathway (HP:0010990)2.99598278
39Abnormality of chloride homeostasis (HP:0011422)2.97410329
40Hypoalphalipoproteinemia (HP:0003233)2.95565173
41Atrophic scars (HP:0001075)2.93661573
42Hyperlipoproteinemia (HP:0010980)2.89549999
43Hyperuricemia (HP:0002149)2.89517896
44Increased purine levels (HP:0004368)2.89517896
45Broad face (HP:0000283)2.89219387
46Abnormality of fatty-acid metabolism (HP:0004359)2.87898080
47Cervical subluxation (HP:0003308)2.80651816
48Abnormal hair laboratory examination (HP:0003328)2.76274275
49Vascular calcification (HP:0004934)2.75588617
50Esophageal varix (HP:0002040)2.74293109
51Abnormality of the intrinsic pathway (HP:0010989)2.73445272
52Alkalosis (HP:0001948)2.72087751
53Abnormal tarsal ossification (HP:0008369)2.71709083
54Plantar hyperkeratosis (HP:0007556)2.65792767
55Glomerulonephritis (HP:0000099)2.63582683
56Protrusio acetabuli (HP:0003179)2.63354808
57Proximal tubulopathy (HP:0000114)2.61881924
58Systemic lupus erythematosus (HP:0002725)2.61476933
59Abdominal distention (HP:0003270)2.60106910
60Late onset (HP:0003584)2.60049156
61Hypoglycemic seizures (HP:0002173)2.56968601
62Upper limb amyotrophy (HP:0009129)2.55524901
63Distal upper limb amyotrophy (HP:0007149)2.55524901
64Advanced eruption of teeth (HP:0006288)2.51134141
65Fragile skin (HP:0001030)2.48733421
66Abnormality of carpal bone ossification (HP:0006257)2.48614294
67Generalized aminoaciduria (HP:0002909)2.47626496
68Metabolic acidosis (HP:0001942)2.47596456
69Flat acetabular roof (HP:0003180)2.45577196
70Cardiovascular calcification (HP:0011915)2.43809610
71Metabolic alkalosis (HP:0200114)2.42979841
72Abnormality of complement system (HP:0005339)2.41861923
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41625086
74Hypercholesterolemia (HP:0003124)2.39949319
75Nephritis (HP:0000123)2.39887941
76Fragile nails (HP:0001808)2.39678005
77Steatorrhea (HP:0002570)2.38189201
78Joint hemorrhage (HP:0005261)2.38142189
79Hyperbilirubinemia (HP:0002904)2.37805538
80Acanthocytosis (HP:0001927)2.37695977
81Symptomatic seizures (HP:0011145)2.37364306
82Bronchomalacia (HP:0002780)2.36548380
83Hyperinsulinemic hypoglycemia (HP:0000825)2.36299640
84Abnormality of nail color (HP:0100643)2.35196022
85Pterygium (HP:0001059)2.34443963
86Abnormality of urine glucose concentration (HP:0011016)2.31970377
87Glycosuria (HP:0003076)2.31970377
88Neonatal death (HP:0003811)2.31608006
89Mildly elevated creatine phosphokinase (HP:0008180)2.30956889
90Nephrolithiasis (HP:0000787)2.29802068
91Stridor (HP:0010307)2.27439912
92Dicarboxylic aciduria (HP:0003215)2.27092234
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27092234
94Premature rupture of membranes (HP:0001788)2.26800863
95Abnormality of the Achilles tendon (HP:0005109)2.26749690
96Dehydration (HP:0001944)2.26047733
97Abnormality of methionine metabolism (HP:0010901)2.25352234
98Hypokalemic alkalosis (HP:0001949)2.24271340
99Distal lower limb amyotrophy (HP:0008944)2.24007733
100Rickets (HP:0002748)2.22656942
101Protuberant abdomen (HP:0001538)2.22182999
102Hepatocellular carcinoma (HP:0001402)2.20844077
103Abnormality of pyrimidine metabolism (HP:0004353)2.19459472
104Abnormal ossification of hand bones (HP:0005921)2.19286675
105Nail dystrophy (HP:0008404)2.18699741
106Distal lower limb muscle weakness (HP:0009053)2.18225899
107Cerebral aneurysm (HP:0004944)2.17861048
108Palmoplantar hyperkeratosis (HP:0000972)2.17153766
109Widely patent fontanelles and sutures (HP:0004492)2.15469014
110Abnormal cartilage morphology (HP:0002763)2.15006439
111Natal tooth (HP:0000695)2.14759419
112Potter facies (HP:0002009)2.12697462
113Facial shape deformation (HP:0011334)2.12697462
114Abnormal enzyme/coenzyme activity (HP:0012379)2.09463492
115Ulnar bowing (HP:0003031)2.08654230
116Short nail (HP:0001799)2.08289346
117Abnormality of vitamin metabolism (HP:0100508)2.07953920
118Hypoplasia of dental enamel (HP:0006297)2.07749461
119J-shaped sella turcica (HP:0002680)2.07263358
120Delayed CNS myelination (HP:0002188)2.07213799
121Abnormality of the distal phalanges of the toes (HP:0010182)2.05403965
122Lethargy (HP:0001254)2.05250658
123Hyperglycemia (HP:0003074)2.04469894
124Skin nodule (HP:0200036)2.03489633
125Irritability (HP:0000737)2.02200858
126Glomerulosclerosis (HP:0000096)2.01261991
127Acanthosis nigricans (HP:0000956)2.00833051
128Myocardial infarction (HP:0001658)2.00748946
129Onycholysis (HP:0001806)2.00259910
130Confusion (HP:0001289)1.99453670
131Hyperacusis (HP:0010780)1.99350637
132Pili torti (HP:0003777)1.99298395
133Achilles tendon contracture (HP:0001771)1.98681266
134Cupped ribs (HP:0000887)1.97520043
135Spastic diplegia (HP:0001264)1.95180049
136Sensorimotor neuropathy (HP:0007141)1.94683368
137Abnormality of alkaline phosphatase activity (HP:0004379)1.94057744
138Palmar hyperkeratosis (HP:0010765)1.91542802
139Enlarged kidneys (HP:0000105)1.91130913
140Focal segmental glomerulosclerosis (HP:0000097)1.90903630
141Pancreatitis (HP:0001733)1.88784362
142Abnormal foot bone ossification (HP:0010675)1.87963807
143Thick nail (HP:0001805)1.87826426
144Abnormality of the gastric mucosa (HP:0004295)1.87269909
145Abnormal blistering of the skin (HP:0008066)1.87238469
146Abnormality of renin-angiotensin system (HP:0000847)1.86895494
147Increased connective tissue (HP:0009025)1.86561628
148Hypophosphatemia (HP:0002148)1.86064488
149Axonal loss (HP:0003447)1.85302166
150Obstructive sleep apnea (HP:0002870)1.85088695
151Abnormal hand bone ossification (HP:0010660)1.82906742
152Asymmetry of the thorax (HP:0001555)1.79951105
153Mitral stenosis (HP:0001718)1.79078286
154Coxa vara (HP:0002812)1.78279116
155Neonatal short-limb short stature (HP:0008921)1.76581883
156Hyperparathyroidism (HP:0000843)1.73372668
157Menorrhagia (HP:0000132)1.71708609
158Hypotrichosis (HP:0001006)1.71693741
159Hypotension (HP:0002615)1.71218926
160Lymphangioma (HP:0100764)1.70671046
161Vertebral compression fractures (HP:0002953)1.70666698
162Hand muscle atrophy (HP:0009130)1.70420932
163Woolly hair (HP:0002224)1.67395557
164Urinary glycosaminoglycan excretion (HP:0003541)1.66847259
165Mucopolysacchariduria (HP:0008155)1.66847259
166Aneurysm (HP:0002617)1.66605060
167Ridged nail (HP:0001807)1.66392594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.98683898
2MST1R3.66284712
3ERN13.62137815
4FRK3.28698462
5BCKDK2.95004152
6MST42.78936832
7WNK32.57073801
8PTK62.56632533
9FGFR42.56275016
10WNK42.55637701
11SIK12.35659689
12ICK2.31264447
13SMG12.26294151
14MAPK152.21174222
15LATS12.17781774
16STK38L2.09563379
17RIPK12.05811299
18LMTK22.05436556
19MAP3K22.03924062
20MAP3K32.03917949
21MAP2K22.02426896
22MET1.86239187
23TRIB31.85345194
24PRKG21.84212737
25TAOK31.75892079
26PTK21.66537666
27FER1.62630179
28INSRR1.60763536
29ERBB41.54210391
30EPHB11.51159545
31PKN21.39163278
32MAP3K61.37293523
33CDK121.29904472
34EPHB21.29734590
35PIK3CG1.24626231
36OXSR11.17428629
37MAP3K101.12092897
38MAP3K71.10513168
39DYRK1B1.09380910
40NME21.08870953
41DDR21.05843454
42NME11.04892764
43MAPKAPK31.02765236
44MAP2K11.02507366
45LRRK21.01781891
46TTN1.01217572
47ERBB21.01046782
48MAPK111.00962618
49RPS6KB20.98572756
50GRK60.94918473
51PRKCI0.93374248
52NUAK10.92748494
53PIK3CA0.92372471
54AKT30.92151423
55PRKD20.90720843
56LATS20.90695502
57MAP3K10.88025339
58RPS6KA20.83657191
59PAK40.83049337
60NTRK10.81662915
61STK100.81373128
62MUSK0.80774505
63MAP3K110.76774943
64PRKAA20.74572882
65PDGFRA0.74229860
66FLT30.70356198
67MARK20.68899043
68TESK10.66874143
69EPHA30.64563596
70GSK3A0.62867116
71ARAF0.62679658
72PIM20.62317887
73BMX0.61614335
74TIE10.59568247
75MAP2K60.58401882
76TAOK10.58302875
77MAP2K30.58252713
78KSR20.58064392
79NEK90.56695944
80TBK10.54420428
81PAK30.53658755
82TYK20.52751932
83MTOR0.52098762
84JAK20.50957701
85STK390.50542396
86IRAK30.49674899
87CSK0.48463090
88PDGFRB0.48275171
89MATK0.47943161
90PRKAA10.47444345
91TESK20.46828536
92CDK60.46749559
93MYLK0.46534018
94TGFBR20.44100521
95STK380.41785348
96PRPF4B0.41424949
97CDK70.40976851
98MAP3K80.40968974
99STK30.40932606
100MAP3K90.38827204
101RPS6KL10.38645782
102RPS6KC10.38645782
103PDPK10.38272283
104MAPKAPK20.38268562
105ILK0.35989252
106HIPK20.35212390
107TYRO30.34976019
108CAMK2G0.34847094
109TRPM70.34032947
110SRC0.32448287
111CHUK0.31205871
112PRKD30.31150305
113FGFR10.29247274
114PRKACG0.28944355
115IRAK20.28058786
116MAP3K120.27791590
117FGFR20.27727367
118SGK30.27708992
119RET0.27644172
120JAK10.27385503
121NEK60.27321917
122PRKCZ0.27098884
123PDK20.26024900
124CDC42BPA0.25933407
125DAPK20.25425859
126KDR0.25242074
127GRK10.24226237
128RPS6KA60.23498368
129NEK10.22894377
130FGFR30.22868408
131EEF2K0.22631828
132STK240.22490247
133DAPK10.21937733
134ABL20.21801037
135CAMK2B0.21741412
136PDK10.20916405
137SCYL20.20430067

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.31880533
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29185229
3Nitrogen metabolism_Homo sapiens_hsa009102.89357543
4Tryptophan metabolism_Homo sapiens_hsa003802.61889106
5Fat digestion and absorption_Homo sapiens_hsa049752.49073201
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47154684
7Arginine biosynthesis_Homo sapiens_hsa002202.46695765
8Sulfur metabolism_Homo sapiens_hsa009202.46482549
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37618770
10Fatty acid degradation_Homo sapiens_hsa000712.36090987
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.35361783
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28884323
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27580712
14Histidine metabolism_Homo sapiens_hsa003402.25916213
15Caffeine metabolism_Homo sapiens_hsa002322.22855079
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99862390
17Vitamin digestion and absorption_Homo sapiens_hsa049771.94033884
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92660980
19Butanoate metabolism_Homo sapiens_hsa006501.92557850
20Bile secretion_Homo sapiens_hsa049761.91406743
21Peroxisome_Homo sapiens_hsa041461.80450306
22Complement and coagulation cascades_Homo sapiens_hsa046101.80144634
23PPAR signaling pathway_Homo sapiens_hsa033201.77924821
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70921088
25Chemical carcinogenesis_Homo sapiens_hsa052041.69545958
26Starch and sucrose metabolism_Homo sapiens_hsa005001.68679630
27Folate biosynthesis_Homo sapiens_hsa007901.67641885
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67187860
29Propanoate metabolism_Homo sapiens_hsa006401.62622241
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59069186
31beta-Alanine metabolism_Homo sapiens_hsa004101.59064510
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.57050298
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56969545
34Selenocompound metabolism_Homo sapiens_hsa004501.55020126
35Fatty acid metabolism_Homo sapiens_hsa012121.47580863
36Phenylalanine metabolism_Homo sapiens_hsa003601.43661392
37Retinol metabolism_Homo sapiens_hsa008301.39668998
38Pyruvate metabolism_Homo sapiens_hsa006201.38328428
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.37703652
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36309843
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.35806296
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30456201
43Mineral absorption_Homo sapiens_hsa049781.26756950
44ABC transporters_Homo sapiens_hsa020101.19159659
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18270716
46Glutathione metabolism_Homo sapiens_hsa004801.17484309
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.13214011
48Tyrosine metabolism_Homo sapiens_hsa003501.13131514
49Arginine and proline metabolism_Homo sapiens_hsa003301.12432596
50Carbon metabolism_Homo sapiens_hsa012001.11743643
51Renin-angiotensin system_Homo sapiens_hsa046141.04898683
52Notch signaling pathway_Homo sapiens_hsa043301.04300167
53Galactose metabolism_Homo sapiens_hsa000521.01832897
54Glycerolipid metabolism_Homo sapiens_hsa005611.00956965
55Protein digestion and absorption_Homo sapiens_hsa049740.99219151
56Biosynthesis of amino acids_Homo sapiens_hsa012300.96243509
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94256117
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93006136
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89972683
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.89500459
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89230540
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.85391275
63Steroid biosynthesis_Homo sapiens_hsa001000.84135713
64Fatty acid elongation_Homo sapiens_hsa000620.84002870
65Lysine degradation_Homo sapiens_hsa003100.83028327
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82872313
67Fructose and mannose metabolism_Homo sapiens_hsa000510.81280086
68Staphylococcus aureus infection_Homo sapiens_hsa051500.77625361
69Focal adhesion_Homo sapiens_hsa045100.74963219
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72409984
71N-Glycan biosynthesis_Homo sapiens_hsa005100.68397961
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66220879
73Sulfur relay system_Homo sapiens_hsa041220.65714645
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63635670
75Pentose phosphate pathway_Homo sapiens_hsa000300.63318185
76Insulin signaling pathway_Homo sapiens_hsa049100.60939764
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59100910
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58472041
79Small cell lung cancer_Homo sapiens_hsa052220.56072143
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.55087787
81Proteoglycans in cancer_Homo sapiens_hsa052050.51427925
82VEGF signaling pathway_Homo sapiens_hsa043700.51296689
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50672137
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49587012
85Linoleic acid metabolism_Homo sapiens_hsa005910.45067442
86Vibrio cholerae infection_Homo sapiens_hsa051100.44495986
87Metabolic pathways_Homo sapiens_hsa011000.43161182
88Axon guidance_Homo sapiens_hsa043600.39580939
89Chronic myeloid leukemia_Homo sapiens_hsa052200.39279042
90Bladder cancer_Homo sapiens_hsa052190.39183981
91Insulin resistance_Homo sapiens_hsa049310.36551212
92GnRH signaling pathway_Homo sapiens_hsa049120.35920242
93Choline metabolism in cancer_Homo sapiens_hsa052310.35487911
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34878607
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34381702
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.30978685
97Thyroid hormone synthesis_Homo sapiens_hsa049180.29528253
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29219518
99Tight junction_Homo sapiens_hsa045300.26169617
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.23309353
101Fatty acid biosynthesis_Homo sapiens_hsa000610.22322146
102Pancreatic secretion_Homo sapiens_hsa049720.21196045
103Arachidonic acid metabolism_Homo sapiens_hsa005900.20790873
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17115876
105Sphingolipid metabolism_Homo sapiens_hsa006000.16992799
106Other glycan degradation_Homo sapiens_hsa005110.15749393
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.15220780
108Adherens junction_Homo sapiens_hsa045200.14855431
109ECM-receptor interaction_Homo sapiens_hsa045120.13816289
110Vitamin B6 metabolism_Homo sapiens_hsa007500.10858309
111Hepatitis C_Homo sapiens_hsa051600.09485775
112One carbon pool by folate_Homo sapiens_hsa006700.09428015
113AMPK signaling pathway_Homo sapiens_hsa041520.06439751
114Glucagon signaling pathway_Homo sapiens_hsa049220.06315977
115Prion diseases_Homo sapiens_hsa050200.05981746
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.05602079
117Amoebiasis_Homo sapiens_hsa051460.04905477
118Thyroid cancer_Homo sapiens_hsa052160.04523700

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