EPS8L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.80760914
2intestinal cholesterol absorption (GO:0030299)7.40479082
3angiotensin maturation (GO:0002003)6.86287279
4flavonoid metabolic process (GO:0009812)5.69437217
5NADH metabolic process (GO:0006734)5.65182604
6bile acid and bile salt transport (GO:0015721)5.57071688
7maintenance of gastrointestinal epithelium (GO:0030277)5.43971533
8actin filament depolymerization (GO:0030042)5.31483946
9vitamin A metabolic process (GO:0006776)5.29351508
10purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.19620676
113-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.19620676
12epoxygenase P450 pathway (GO:0019373)5.08511287
13fat-soluble vitamin biosynthetic process (GO:0042362)5.06910770
14regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.94904294
15endocrine process (GO:0050886)4.94904294
16regulation of systemic arterial blood pressure by hormone (GO:0001990)4.94904294
17digestive system process (GO:0022600)4.83976811
18bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75721414
19sulfate transmembrane transport (GO:1902358)4.72768890
20regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.46838617
21fructose metabolic process (GO:0006000)4.46541403
22regulation of systemic arterial blood pressure (GO:0003073)4.44743788
23sulfation (GO:0051923)4.38410927
24intestinal epithelial cell development (GO:0060576)4.34215111
25regulation of cellular extravasation (GO:0002691)4.27667365
26drug catabolic process (GO:0042737)4.18323188
27epithelial structure maintenance (GO:0010669)4.15781680
28regulation of bile acid biosynthetic process (GO:0070857)4.08795661
29renal system process involved in regulation of blood volume (GO:0001977)4.08655848
30cellular glucuronidation (GO:0052695)4.06919405
31urea cycle (GO:0000050)4.03702024
32sperm capacitation (GO:0048240)4.02882862
33drug metabolic process (GO:0017144)4.01824985
34glucuronate metabolic process (GO:0019585)3.99594424
35uronic acid metabolic process (GO:0006063)3.99594424
36regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.97033297
37virion attachment to host cell (GO:0019062)3.96818840
38adhesion of symbiont to host cell (GO:0044650)3.96818840
39bicarbonate transport (GO:0015701)3.93208550
40UDP-N-acetylglucosamine metabolic process (GO:0006047)3.91878224
41peptide catabolic process (GO:0043171)3.91590748
42protein-lipid complex remodeling (GO:0034368)3.91518786
43macromolecular complex remodeling (GO:0034367)3.91518786
44plasma lipoprotein particle remodeling (GO:0034369)3.91518786
45high-density lipoprotein particle remodeling (GO:0034375)3.90146157
46urea metabolic process (GO:0019627)3.88336219
47plasma lipoprotein particle organization (GO:0071827)3.87928455
48calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.84763401
49sulfur compound transport (GO:0072348)3.83457177
50regulation of cGMP biosynthetic process (GO:0030826)3.80160926
51sulfate transport (GO:0008272)3.79429052
52positive regulation of pseudopodium assembly (GO:0031274)3.78912602
53low-density lipoprotein particle remodeling (GO:0034374)3.73363652
54protein-lipid complex subunit organization (GO:0071825)3.70912628
55vocalization behavior (GO:0071625)3.68249910
56digestion (GO:0007586)3.65286961
57regulation of guanylate cyclase activity (GO:0031282)3.62440568
58renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.61528485
59O-glycan processing (GO:0016266)3.60753246
60regulation of vitamin metabolic process (GO:0030656)3.56578780
61positive regulation of respiratory burst (GO:0060267)3.55770390
62sodium ion export (GO:0071436)3.55516914
63nitrogen cycle metabolic process (GO:0071941)3.53969852
64positive regulation of lipid catabolic process (GO:0050996)3.50363344
65glucose 6-phosphate metabolic process (GO:0051156)3.49604234
66glutamine family amino acid biosynthetic process (GO:0009084)3.45161664
67peptide hormone processing (GO:0016486)3.44756568
68thyroid hormone metabolic process (GO:0042403)3.44104314
69desmosome organization (GO:0002934)3.43219478
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.42297667
71ethanol oxidation (GO:0006069)3.41837920
72modified amino acid transport (GO:0072337)3.41767821
73response to hepatocyte growth factor (GO:0035728)3.40547398
74cellular response to hepatocyte growth factor stimulus (GO:0035729)3.40547398
75membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.40186784
76phospholipid efflux (GO:0033700)3.39480902
77reverse cholesterol transport (GO:0043691)3.38734927
78regulation of pseudopodium assembly (GO:0031272)3.36754700
79negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.36022570
80cholesterol efflux (GO:0033344)3.34856064
81complement activation, classical pathway (GO:0006958)3.33437727
82positive regulation of glycoprotein biosynthetic process (GO:0010560)3.29130242
83negative regulation of protein tyrosine kinase activity (GO:0061099)3.28225627
84phosphatidylcholine biosynthetic process (GO:0006656)3.24161970
85phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.23850335
86drinking behavior (GO:0042756)3.21750450
87regulation of viral release from host cell (GO:1902186)3.21232804
88arginine metabolic process (GO:0006525)3.20816648
89cellular potassium ion homeostasis (GO:0030007)3.20685257
90triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20289839
91cell communication involved in cardiac conduction (GO:0086065)3.20098654
92regulation of triglyceride catabolic process (GO:0010896)3.17515298
93plasma lipoprotein particle assembly (GO:0034377)3.16516416
94glycosphingolipid catabolic process (GO:0046479)3.15638741
95negative regulation of keratinocyte proliferation (GO:0010839)3.14434168
96glycolipid catabolic process (GO:0019377)3.14230545
97drug transport (GO:0015893)3.12709823
98pyrimidine-containing compound transmembrane transport (GO:0072531)3.12297846
99adhesion of symbiont to host (GO:0044406)3.11600058
100positive regulation of Cdc42 GTPase activity (GO:0043089)3.11137957
101regulation of actin nucleation (GO:0051125)3.10844110
102hormone catabolic process (GO:0042447)3.10583457
103protein-lipid complex assembly (GO:0065005)3.09397548
104transcytosis (GO:0045056)3.08611812
105regulation of cGMP metabolic process (GO:0030823)3.07987145
106diacylglycerol metabolic process (GO:0046339)3.07367077
107lipoprotein transport (GO:0042953)3.06213300
108positive regulation of triglyceride lipase activity (GO:0061365)3.05528583
109positive regulation of lipoprotein lipase activity (GO:0051006)3.05528583
110drug transmembrane transport (GO:0006855)3.05457653
111glomerular filtration (GO:0003094)3.04357554
112regulation of cholesterol homeostasis (GO:2000188)3.03755773
113nucleoside diphosphate biosynthetic process (GO:0009133)3.03706817
114GDP-mannose metabolic process (GO:0019673)3.03241920
115striated muscle atrophy (GO:0014891)3.03034047
116homocysteine metabolic process (GO:0050667)3.02897861
117ventricular cardiac muscle cell action potential (GO:0086005)3.02371897
118membrane repolarization during action potential (GO:0086011)3.02042008
119cGMP-mediated signaling (GO:0019934)3.00356205
120thrombin receptor signaling pathway (GO:0070493)2.99283116
121sexual reproduction (GO:0019953)2.98485481
122positive regulation of guanylate cyclase activity (GO:0031284)2.98389607
123negative regulation of sodium ion transport (GO:0010766)2.98277675
124bile acid metabolic process (GO:0008206)2.98141565
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.97862808
126auditory receptor cell differentiation (GO:0042491)2.95309816
127neurotransmitter biosynthetic process (GO:0042136)2.95118290
128positive regulation of glycoprotein metabolic process (GO:1903020)2.94904543
129alkaloid metabolic process (GO:0009820)2.94612112
130hemidesmosome assembly (GO:0031581)2.93918138
131lipoprotein metabolic process (GO:0042157)2.93909127
132vitamin transmembrane transport (GO:0035461)2.93160901
133regulation of cholesterol esterification (GO:0010872)2.91851040
134very-low-density lipoprotein particle assembly (GO:0034379)2.88201991
135regulation of respiratory burst (GO:0060263)2.87853851
136cardiac conduction (GO:0061337)2.80751154
137positive regulation of T cell differentiation in thymus (GO:0033089)2.77343169
138antibacterial humoral response (GO:0019731)2.77094234
139receptor guanylyl cyclase signaling pathway (GO:0007168)2.73807306
140transepithelial transport (GO:0070633)2.73672760
141hepatocyte apoptotic process (GO:0097284)2.73032537
142regulation of protein glycosylation (GO:0060049)2.72599667
143cytidine metabolic process (GO:0046087)2.70263265
144cytidine catabolic process (GO:0006216)2.70263265
145cytidine deamination (GO:0009972)2.70263265
146ribonucleoside bisphosphate metabolic process (GO:0033875)2.68566536
147nucleoside bisphosphate metabolic process (GO:0033865)2.68566536
148purine nucleoside bisphosphate metabolic process (GO:0034032)2.68566536
149antimicrobial humoral response (GO:0019730)2.68349652
150cholesterol homeostasis (GO:0042632)2.67876955
151regulation of heart rate by cardiac conduction (GO:0086091)2.66953587
152skeletal muscle adaptation (GO:0043501)2.65794088
153sterol homeostasis (GO:0055092)2.65678782
154response to histamine (GO:0034776)2.65168979
155negative regulation of cholesterol transport (GO:0032375)2.64386162
156negative regulation of sterol transport (GO:0032372)2.64386162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.03547288
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.38439653
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.11702640
4CDX2_19796622_ChIP-Seq_MESCs_Mouse2.76880598
5SOX2_20726797_ChIP-Seq_SW620_Human2.31036789
6GATA4_25053715_ChIP-Seq_YYC3_Human2.28033326
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15880164
8SRY_22984422_ChIP-ChIP_TESTIS_Rat2.13274161
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.12476753
10* GATA6_25053715_ChIP-Seq_YYC3_Human2.08071839
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04109159
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.02765835
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97060975
14DROSHA_22980978_ChIP-Seq_HELA_Human1.96242042
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94111409
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81606829
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79922313
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73911407
19* KLF5_25053715_ChIP-Seq_YYC3_Human1.71168898
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68068934
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65079759
22* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64163371
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.61249028
24ZNF263_19887448_ChIP-Seq_K562_Human1.58195511
25CLOCK_20551151_ChIP-Seq_293T_Human1.56182625
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55672644
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53205077
28PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51874610
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.50985806
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.50975555
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49686300
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.47264046
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.45480620
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43043394
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.40518325
36* RUNX1_27514584_Chip-Seq_MCF-7_Human1.39815308
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39008354
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38263100
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37477811
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.37048182
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34929203
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.32975248
43GATA1_26923725_Chip-Seq_HPCs_Mouse1.31263246
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30656432
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30611178
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.29890607
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.28973848
48EZH2_22144423_ChIP-Seq_EOC_Human1.28796259
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27813227
50VDR_22108803_ChIP-Seq_LS180_Human1.27267520
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25486369
52BCOR_27268052_Chip-Seq_Bcells_Human1.25143509
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24242952
54RACK7_27058665_Chip-Seq_MCF-7_Human1.22506157
55BCL6_27268052_Chip-Seq_Bcells_Human1.22169080
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21626013
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21547321
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.19515170
59* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19416965
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19204483
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.18455289
62JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.18299145
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12979688
64* SA1_27219007_Chip-Seq_Bcells_Human1.12596848
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12448197
66SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11842458
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11841907
68CTCF_27219007_Chip-Seq_Bcells_Human1.11444741
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11073347
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11041978
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10516326
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09919856
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08176133
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05144123
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05113987
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05036682
77EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04027056
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04027056
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03466822
80PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03455648
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03242570
82GATA1_22025678_ChIP-Seq_K562_Human1.02702164
83RXR_22108803_ChIP-Seq_LS180_Human1.02317850
84GATA2_19941826_ChIP-Seq_K562_Human1.01821523
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01705333
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.00464420
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99970183
88CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98932435
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98154502
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97969999
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.96932080
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.96648291
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95982972
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.95817895
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95563710
96P68_20966046_ChIP-Seq_HELA_Human0.95421977
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95406738
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95099071
99ATF3_27146783_Chip-Seq_COLON_Human0.94977838
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94350463
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94203937
102LXR_22292898_ChIP-Seq_THP-1_Human0.94157740
103GATA1_19941826_ChIP-Seq_K562_Human0.93199130
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92957074
105E2F1_20622854_ChIP-Seq_HELA_Human0.92177830
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91681639
107CREB1_26743006_Chip-Seq_LNCaP_Human0.91134813
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91000646
109PHF8_20622854_ChIP-Seq_HELA_Human0.90998769
110CEBPB_22108803_ChIP-Seq_LS180_Human0.90627048
111* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89622315
112HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89348497
113JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88672562
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88595690
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88367450
116TP63_22573176_ChIP-Seq_HFKS_Human0.87291183
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87273751
118GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87092790
119GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86266216
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.84941050
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84777488
122ETS1_21867929_ChIP-Seq_TH2_Mouse0.84677639
123TP53_16413492_ChIP-PET_HCT116_Human0.84602047
124REST_21632747_ChIP-Seq_MESCs_Mouse0.84594576
125* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84545035
126RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84277253
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.83707658
128* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83579338
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82787358
130AHR_22903824_ChIP-Seq_MCF-7_Human0.80921403
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.80877027
132UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80451182
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80315650
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79828633
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79345161
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79197524
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78974385
138CDX2_22108803_ChIP-Seq_LS180_Human0.78969203
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78866315
140RING1B_27294783_Chip-Seq_ESCs_Mouse0.78806289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.16459610
2MP0005360_urolithiasis6.43175607
3MP0001666_abnormal_nutrient_absorption4.83978858
4MP0002822_catalepsy4.66261302
5MP0004264_abnormal_extraembryonic_tissu3.78973950
6MP0000462_abnormal_digestive_system3.41967892
7MP0003866_abnormal_defecation3.17362101
8MP0005377_hearing/vestibular/ear_phenot3.08134319
9MP0003878_abnormal_ear_physiology3.08134319
10MP0003283_abnormal_digestive_organ2.71244549
11MP0005085_abnormal_gallbladder_physiolo2.51482303
12MP0001663_abnormal_digestive_system2.39645310
13MP0002139_abnormal_hepatobiliary_system2.38710639
14MP0001664_abnormal_digestion2.37943143
15MP0008875_abnormal_xenobiotic_pharmacok2.37571124
16MP0003183_abnormal_peptide_metabolism2.34803182
17MP0001873_stomach_inflammation2.32825206
18MP0005381_digestive/alimentary_phenotyp2.31875314
19MP0003252_abnormal_bile_duct2.31178291
20MP0005409_darkened_coat_color2.24412550
21MP0000537_abnormal_urethra_morphology2.06056431
22MP0009840_abnormal_foam_cell2.00338117
23MP0010155_abnormal_intestine_physiology1.95051996
24MP0000477_abnormal_intestine_morphology1.83295895
25MP0005167_abnormal_blood-brain_barrier1.82906366
26MP0010329_abnormal_lipoprotein_level1.82905514
27MP0004043_abnormal_pH_regulation1.81981695
28MP0004270_analgesia1.81760849
29MP0000490_abnormal_crypts_of1.81237103
30MP0005670_abnormal_white_adipose1.76171546
31MP0004019_abnormal_vitamin_homeostasis1.64865082
32MP0000538_abnormal_urinary_bladder1.51709473
33MP0003300_gastrointestinal_ulcer1.50132406
34MP0010678_abnormal_skin_adnexa1.49834001
35MP0008872_abnormal_physiological_respon1.46169594
36MP0002796_impaired_skin_barrier1.43452008
37MP0000566_synostosis1.43278638
38MP0001849_ear_inflammation1.42459877
39MP0004147_increased_porphyrin_level1.40181920
40MP0003315_abnormal_perineum_morphology1.35428189
41MP0003879_abnormal_hair_cell1.34950936
42MP0009780_abnormal_chondrocyte_physiolo1.33287615
43MP0003705_abnormal_hypodermis_morpholog1.32770237
44MP0004859_abnormal_synaptic_plasticity1.31809796
45MP0005084_abnormal_gallbladder_morpholo1.31418062
46MP0001765_abnormal_ion_homeostasis1.28192581
47MP0010352_gastrointestinal_tract_polyps1.26422935
48MP0004782_abnormal_surfactant_physiolog1.23860343
49MP0001764_abnormal_homeostasis1.23380650
50MP0005365_abnormal_bile_salt1.20267753
51MP0002138_abnormal_hepatobiliary_system1.19181687
52MP0001756_abnormal_urination1.16202502
53MP0001501_abnormal_sleep_pattern1.15882463
54MP0003868_abnormal_feces_composition1.15668482
55MP0005058_abnormal_lysosome_morphology1.08873346
56MP0002876_abnormal_thyroid_physiology1.05687175
57MP0003191_abnormal_cellular_cholesterol1.04032685
58MP0004858_abnormal_nervous_system1.03434872
59MP0005448_abnormal_energy_balance0.99943120
60MP0008004_abnormal_stomach_pH0.99136943
61MP0005166_decreased_susceptibility_to0.97470434
62MP0009643_abnormal_urine_homeostasis0.95843771
63MP0001188_hyperpigmentation0.88484747
64MP0000467_abnormal_esophagus_morphology0.87710012
65MP0002971_abnormal_brown_adipose0.87557671
66MP0005410_abnormal_fertilization0.87174855
67MP0004947_skin_inflammation0.86180555
68MP0002166_altered_tumor_susceptibility0.84514648
69MP0009115_abnormal_fat_cell0.82537170
70MP0002118_abnormal_lipid_homeostasis0.80173617
71MP0003453_abnormal_keratinocyte_physiol0.79912352
72MP0002734_abnormal_mechanical_nocicepti0.79646527
73MP0005636_abnormal_mineral_homeostasis0.77952683
74MP0005310_abnormal_salivary_gland0.77889391
75MP0004885_abnormal_endolymph0.77570528
76MP0006054_spinal_hemorrhage0.77314846
77MP0002098_abnormal_vibrissa_morphology0.77261992
78MP0001485_abnormal_pinna_reflex0.76019564
79MP0005666_abnormal_adipose_tissue0.75710446
80MP0009642_abnormal_blood_homeostasis0.75471277
81MP0001845_abnormal_inflammatory_respons0.75355335
82MP0000470_abnormal_stomach_morphology0.74923673
83MP0005501_abnormal_skin_physiology0.74778969
84MP0002089_abnormal_postnatal_growth/wei0.74466789
85MP0001440_abnormal_grooming_behavior0.73580935
86MP0000604_amyloidosis0.71563305
87MP0003329_amyloid_beta_deposits0.71027439
88MP0009379_abnormal_foot_pigmentation0.70820352
89MP0003436_decreased_susceptibility_to0.69609041
90MP0002896_abnormal_bone_mineralization0.69362111
91MP0000230_abnormal_systemic_arterial0.69277614
92MP0000465_gastrointestinal_hemorrhage0.68970007
93MP0002909_abnormal_adrenal_gland0.68473309
94MP0008469_abnormal_protein_level0.68232174
95MP0000249_abnormal_blood_vessel0.67727566
96MP0003718_maternal_effect0.67017203
97MP0009785_altered_susceptibility_to0.66058964
98MP0009384_cardiac_valve_regurgitation0.63655085
99MP0002234_abnormal_pharynx_morphology0.61236252
100MP0005025_abnormal_response_to0.60487827
101MP0001216_abnormal_epidermal_layer0.60444843
102MP0000678_abnormal_parathyroid_gland0.59205539
103MP0002733_abnormal_thermal_nociception0.58739966
104MP0009333_abnormal_splenocyte_physiolog0.58469138
105MP0005535_abnormal_body_temperature0.58273984
106MP0009053_abnormal_anal_canal0.58248357
107MP0003075_altered_response_to0.57920562
108MP0003045_fibrosis0.56718174
109MP0003635_abnormal_synaptic_transmissio0.56189391
110MP0005257_abnormal_intraocular_pressure0.55916454
111MP0002254_reproductive_system_inflammat0.55887612
112MP0005332_abnormal_amino_acid0.54078778
113MP0003724_increased_susceptibility_to0.53944799
114MP0003953_abnormal_hormone_level0.53855704
115MP0005451_abnormal_body_composition0.53036696
116MP0002078_abnormal_glucose_homeostasis0.52631586
117MP0003950_abnormal_plasma_membrane0.52402094
118MP0003806_abnormal_nucleotide_metabolis0.52240396
119MP0003303_peritoneal_inflammation0.52201096
120MP0004484_altered_response_of0.51400131
121MP0003638_abnormal_response/metabolism_0.48594990
122MP0002006_tumorigenesis0.48033631
123MP0005165_increased_susceptibility_to0.47057164
124MP0001486_abnormal_startle_reflex0.47002102
125MP0002132_abnormal_respiratory_system0.45753512
126MP0005023_abnormal_wound_healing0.44942278
127MP0009745_abnormal_behavioral_response0.44928647
128MP0004185_abnormal_adipocyte_glucose0.44618031
129MP0001970_abnormal_pain_threshold0.44406226
130MP0002136_abnormal_kidney_physiology0.44234672
131MP0005584_abnormal_enzyme/coenzyme_acti0.43389138
132MP0005319_abnormal_enzyme/_coenzyme0.41866792
133MP0000609_abnormal_liver_physiology0.40868343
134MP0008873_increased_physiological_sensi0.40370871
135MP0002063_abnormal_learning/memory/cond0.40300803
136MP0008569_lethality_at_weaning0.39845001

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.66182317
2Right ventricular cardiomyopathy (HP:0011663)5.68827739
3Malnutrition (HP:0004395)5.18627326
4Acanthocytosis (HP:0001927)4.82380325
5Abnormality of glutamine family amino acid metabolism (HP:0010902)4.78124816
6Systemic lupus erythematosus (HP:0002725)4.72636566
7Cupped ribs (HP:0000887)4.66396110
8Flat acetabular roof (HP:0003180)4.33711477
9Abdominal distention (HP:0003270)4.22657382
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.04089239
11Hemorrhage of the eye (HP:0011885)4.04088787
12Abnormality of small intestinal villus morphology (HP:0011472)3.98147758
13Villous atrophy (HP:0011473)3.98147758
14Hyperactive renin-angiotensin system (HP:0000841)3.84523292
15Conjugated hyperbilirubinemia (HP:0002908)3.76682229
16Abnormality of the 1st metacarpal (HP:0010009)3.74296432
17Metabolic alkalosis (HP:0200114)3.70813959
18Hypobetalipoproteinemia (HP:0003563)3.70018988
19Xanthomatosis (HP:0000991)3.61533329
20Hydroxyprolinuria (HP:0003080)3.57124178
21Abnormality of proline metabolism (HP:0010907)3.57124178
22Complement deficiency (HP:0004431)3.42829474
23Widely patent fontanelles and sutures (HP:0004492)3.42539211
24Ventricular fibrillation (HP:0001663)3.34548014
25Chronic diarrhea (HP:0002028)3.28825308
26Pustule (HP:0200039)3.28626571
27Abnormality of the distal phalanx of the thumb (HP:0009617)3.28494600
28Glomerulonephritis (HP:0000099)3.27718514
29Alkalosis (HP:0001948)3.26770324
30Symphalangism affecting the phalanges of the hand (HP:0009773)3.16236148
31Abnormality of complement system (HP:0005339)3.16148876
32Progressive sensorineural hearing impairment (HP:0000408)3.13789683
33Hyperglycinuria (HP:0003108)3.12495549
34Mildly elevated creatine phosphokinase (HP:0008180)3.05985248
35Pili torti (HP:0003777)3.05201827
36Dehydration (HP:0001944)2.99310175
37Abnormality of the vitamin B12 metabolism (HP:0004341)2.96541374
38Congenital sensorineural hearing impairment (HP:0008527)2.95908045
39Deep venous thrombosis (HP:0002625)2.95900907
40Abnormal tarsal ossification (HP:0008369)2.94779278
41Proximal tubulopathy (HP:0000114)2.94550084
42Milia (HP:0001056)2.94075136
43Gastrointestinal dysmotility (HP:0002579)2.93728985
44Nausea (HP:0002018)2.89743122
45Syncope (HP:0001279)2.87813200
46Hyperuricemia (HP:0002149)2.85292865
47Increased purine levels (HP:0004368)2.85292865
48Autoimmune thrombocytopenia (HP:0001973)2.83486248
49Focal segmental glomerulosclerosis (HP:0000097)2.79013651
50Fat malabsorption (HP:0002630)2.78496451
51Abnormality of glycine metabolism (HP:0010895)2.77815521
52Abnormality of serine family amino acid metabolism (HP:0010894)2.77815521
53Abnormality of chloride homeostasis (HP:0011422)2.77160290
54Progressive hearing impairment (HP:0001730)2.75424068
55Abnormality of vitamin B metabolism (HP:0004340)2.75125801
56Fragile nails (HP:0001808)2.75069720
57Abnormality of carpal bone ossification (HP:0006257)2.67119285
58Myokymia (HP:0002411)2.60185271
59Short phalanx of the thumb (HP:0009660)2.59817940
60Neonatal short-limb short stature (HP:0008921)2.59447377
61Hypotension (HP:0002615)2.59020886
62Bundle branch block (HP:0011710)2.53071520
63Steatorrhea (HP:0002570)2.52566135
64Woolly hair (HP:0002224)2.52308856
65Hypolipoproteinemia (HP:0010981)2.51071244
66Hypophosphatemia (HP:0002148)2.50973325
67Micronodular cirrhosis (HP:0001413)2.49699711
68Poikilocytosis (HP:0004447)2.49600994
69Abnormality of renin-angiotensin system (HP:0000847)2.49024127
70Nephritis (HP:0000123)2.48112574
71Gout (HP:0001997)2.47256682
72Hyperammonemia (HP:0001987)2.46398201
73Palpitations (HP:0001962)2.44838951
74Abnormal biliary tract morphology (HP:0012440)2.41028740
75Potter facies (HP:0002009)2.37561531
76Facial shape deformation (HP:0011334)2.37561531
77Abnormality of vitamin metabolism (HP:0100508)2.35400826
78Glomerulosclerosis (HP:0000096)2.35311965
79Hyperparathyroidism (HP:0000843)2.34869704
80Abnormality of purine metabolism (HP:0004352)2.33410349
81Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.31133712
82Abnormality of the phalanges of the hallux (HP:0010057)2.30466379
83Autoimmune hemolytic anemia (HP:0001890)2.29738866
84Cholecystitis (HP:0001082)2.27712614
85Abnormal gallbladder physiology (HP:0012438)2.27712614
86Alopecia of scalp (HP:0002293)2.26939592
87Goiter (HP:0000853)2.26537168
88Pigmentary retinal degeneration (HP:0001146)2.26442042
89Abnormality of nucleobase metabolism (HP:0010932)2.25946759
90Intrahepatic cholestasis (HP:0001406)2.25937541
91Onycholysis (HP:0001806)2.25561566
92Abnormality of the 2nd finger (HP:0004100)2.25164974
93Biliary tract neoplasm (HP:0100574)2.25022002
94Ureteral stenosis (HP:0000071)2.24131220
95Thin bony cortex (HP:0002753)2.23387260
96Abnormality of the gastric mucosa (HP:0004295)2.20572026
97Hoarse voice (HP:0001609)2.20243502
98Abnormality of the middle phalanges of the toes (HP:0010183)2.19338074
99Atrophic scars (HP:0001075)2.19135808
100Flattened epiphyses (HP:0003071)2.19100254
101Decreased circulating renin level (HP:0003351)2.18002661
102Plantar hyperkeratosis (HP:0007556)2.17721325
103Abnormality of the proximal phalanges of the hand (HP:0009834)2.15910832
104Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.12109050
105Prolonged QT interval (HP:0001657)2.11197449
106Subcapsular cataract (HP:0000523)2.11116412
107Epidermoid cyst (HP:0200040)2.09838315
108Abnormality of pyrimidine metabolism (HP:0004353)2.09662564
109Enlarged epiphyses (HP:0010580)2.08878685
110Abnormal hand bone ossification (HP:0010660)2.07852829
111Fragile skin (HP:0001030)2.07794618
112Megaloblastic anemia (HP:0001889)2.07778950
113Eczematoid dermatitis (HP:0000976)2.05998813
114Delayed epiphyseal ossification (HP:0002663)2.04902610
115Ureteral obstruction (HP:0006000)2.03836157
116Protuberant abdomen (HP:0001538)2.03717952
117Abnormality of urine glucose concentration (HP:0011016)2.00160235
118Glycosuria (HP:0003076)2.00160235
119Confusion (HP:0001289)1.99838254
120Male infertility (HP:0003251)1.99723028
121Curly hair (HP:0002212)1.99196881
122Late onset (HP:0003584)1.98447295
123Hyperaldosteronism (HP:0000859)1.98230836
124Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98122931
125Ventricular arrhythmia (HP:0004308)1.97388220
126Abnormal urine phosphate concentration (HP:0012599)1.97083065
127Renal tubular acidosis (HP:0001947)1.97033257
128Hypoplasia of dental enamel (HP:0006297)1.96886558
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.96680463
130Vascular calcification (HP:0004934)1.95768556
131Cerebral palsy (HP:0100021)1.95548657
132Pancreatitis (HP:0001733)1.94597596
133Rectal prolapse (HP:0002035)1.94030578
134Cone-rod dystrophy (HP:0000548)1.93818672
135Abnormal hair laboratory examination (HP:0003328)1.93054163
136Abnormal ossification of hand bones (HP:0005921)1.92297321
137Aplasia/hypoplasia of the femur (HP:0005613)1.92175727
138Wide cranial sutures (HP:0010537)1.92091640
139Abnormal foot bone ossification (HP:0010675)1.92038209
140Myopathic facies (HP:0002058)1.89265912
141Growth hormone excess (HP:0000845)1.89203653
142Polygenic inheritance (HP:0010982)1.88851585
143Hyperphosphatemia (HP:0002905)1.88693789
144Abnormality of the costochondral junction (HP:0000919)1.86761121
145Nephrolithiasis (HP:0000787)1.86750553
146Dicarboxylic aciduria (HP:0003215)1.84446703
147Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84446703
148Hyperphosphaturia (HP:0003109)1.82124854
149Metabolic acidosis (HP:0001942)1.81792933
150Segmental peripheral demyelination/remyelination (HP:0003481)1.78995772
151Posterior subcapsular cataract (HP:0007787)1.76021572
152Hyponatremia (HP:0002902)1.74744638
153Hypokalemia (HP:0002900)1.73852125
154Abnormality of potassium homeostasis (HP:0011042)1.71406519
155Abnormality of alkaline phosphatase activity (HP:0004379)1.70674129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.54981936
2ACVR1B5.13588533
3FRK4.91689755
4PIK3CA4.50244592
5LMTK24.32225700
6FGFR43.32452404
7RIPK13.17501193
8MAP2K23.17064993
9NME13.16783826
10MST43.14913191
11MAP3K23.02374433
12KSR22.81249511
13PRKG22.57270608
14TAOK32.52266453
15TAOK12.19260746
16EPHB22.02334347
17GRK61.95522523
18MET1.86663266
19TESK11.85092119
20FGFR31.72986684
21MAP3K91.71444568
22EPHA21.51889315
23DDR21.35832375
24PTK61.34863929
25MAP2K11.32138677
26EPHA41.29895152
27TYK21.28860566
28MAP3K121.23402628
29STK241.21473943
30SIK11.18406259
31RIPK41.16323313
32TRIB31.13717508
33MAP3K11.10069632
34MAP2K61.07834791
35MYLK1.05080035
36PRKD31.03834485
37MATK1.03593554
38CAMK2D1.03072844
39MAP4K11.01884796
40EPHA30.99907939
41DYRK1B0.98904620
42PTK20.97927230
43PDGFRA0.95753107
44IRAK30.91710469
45PDK20.79508932
46MAP3K80.77693564
47DMPK0.77629087
48PRKCI0.77197495
49PRPF4B0.76947706
50PDPK10.76326716
51AKT30.74914560
52ICK0.74817482
53NUAK10.73486154
54TBK10.72194963
55PDK40.71484680
56PDK30.71484680
57ERBB20.70375725
58TESK20.70124884
59ERN10.69841109
60ARAF0.66698133
61MAP3K100.66624096
62MAP3K70.66598560
63FER0.62751821
64PDK10.62410349
65SMG10.62114899
66MAP3K110.61025425
67NTRK30.60997536
68CAMK2B0.60214440
69TYRO30.59136476
70CAMKK10.58987816
71CAMK2G0.55793239
72TTK0.54071871
73STK390.52181881
74ZAP700.51801563
75CDK50.49891825
76STK100.49863697
77STK110.49608641
78TNIK0.49200668
79ERBB40.48023534
80LIMK10.47368854
81OXSR10.45822656
82NLK0.45751830
83BRAF0.45329054
84CSF1R0.44722787
85PRKAA20.44422713
86PRKCA0.43622058
87CDC42BPA0.41709304
88WNK40.41406948
89PRKCZ0.40440198
90IRAK10.38595184
91PAK30.38241362
92SRC0.37989783
93MAPK110.37882227
94BMX0.37495736
95PAK40.36439061
96PTK2B0.36021739
97MUSK0.35642663
98PKN20.34688413
99RET0.34263876
100EEF2K0.32722142
101EPHB10.32066555
102PAK60.30943884
103MAP3K30.30007967
104CDK150.28842837
105CAMK2A0.28626118
106PRKAA10.28424557
107CDK180.26257235
108JAK10.26055512
109ROCK10.25961594
110MINK10.24815700
111PDGFRB0.24754288
112ABL20.24524486
113KSR10.24457822
114CDK11A0.24347514
115CSNK1A10.24035150
116CDK190.23912313
117FGR0.23632991
118FYN0.23460659
119YES10.23204441
120PIK3CG0.22770066
121CSK0.22452877
122FGFR10.21541364
123CDK90.21400421
124DAPK20.21223855
125WNK10.21213123
126MAPKAPK20.21135685
127IGF1R0.21129661
128MAP3K130.20972894
129PRKACG0.20779236
130TAOK20.20422045
131CDK60.20220884
132PRKCD0.19257188
133PAK10.19012160
134ITK0.18209570
135MAP3K40.17857231
136IRAK40.17700224
137IKBKE0.17698862
138JAK20.17139024
139MAP3K60.15951955
140MELK0.14601723

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.67898498
2Mineral absorption_Homo sapiens_hsa049784.29340023
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.01250770
4Sulfur metabolism_Homo sapiens_hsa009203.88686309
5Renin-angiotensin system_Homo sapiens_hsa046142.94820134
6Bile secretion_Homo sapiens_hsa049762.72635502
7Vitamin digestion and absorption_Homo sapiens_hsa049772.49544217
8Galactose metabolism_Homo sapiens_hsa000522.22735366
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.20475576
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.19055432
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02764844
12Fructose and mannose metabolism_Homo sapiens_hsa000511.92268100
13Retinol metabolism_Homo sapiens_hsa008301.77126950
14Protein digestion and absorption_Homo sapiens_hsa049741.71394931
15Starch and sucrose metabolism_Homo sapiens_hsa005001.70515237
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.65240031
17Drug metabolism - other enzymes_Homo sapiens_hsa009831.61470364
18Caffeine metabolism_Homo sapiens_hsa002321.61251375
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.57418361
20Glycerolipid metabolism_Homo sapiens_hsa005611.43168574
21Nitrogen metabolism_Homo sapiens_hsa009101.42285367
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39632994
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.38704299
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34974371
25Salivary secretion_Homo sapiens_hsa049701.32697415
26Pancreatic secretion_Homo sapiens_hsa049721.28780159
27Histidine metabolism_Homo sapiens_hsa003401.27317795
28Other glycan degradation_Homo sapiens_hsa005111.26787982
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25929559
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20587910
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19123973
32Complement and coagulation cascades_Homo sapiens_hsa046101.18685720
33PPAR signaling pathway_Homo sapiens_hsa033201.18508418
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18343115
35Gastric acid secretion_Homo sapiens_hsa049711.12475168
36Tight junction_Homo sapiens_hsa045301.12171590
37Staphylococcus aureus infection_Homo sapiens_hsa051501.06645104
38Folate biosynthesis_Homo sapiens_hsa007901.05679013
39Phenylalanine metabolism_Homo sapiens_hsa003601.04900244
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02580231
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02177251
42Thyroid hormone synthesis_Homo sapiens_hsa049181.01708588
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00602046
44Glutathione metabolism_Homo sapiens_hsa004800.99337380
45Sphingolipid metabolism_Homo sapiens_hsa006000.96183136
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.95571716
47Linoleic acid metabolism_Homo sapiens_hsa005910.94946189
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91404012
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87836116
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84519905
51Fatty acid metabolism_Homo sapiens_hsa012120.84011129
52Asthma_Homo sapiens_hsa053100.83004883
53Insulin secretion_Homo sapiens_hsa049110.80866576
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80504476
55Fatty acid degradation_Homo sapiens_hsa000710.72254022
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.71275774
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.71082998
58Pentose phosphate pathway_Homo sapiens_hsa000300.69964494
59Arginine biosynthesis_Homo sapiens_hsa002200.69936303
60Tryptophan metabolism_Homo sapiens_hsa003800.68687743
61Type II diabetes mellitus_Homo sapiens_hsa049300.67940807
62Sulfur relay system_Homo sapiens_hsa041220.67894502
63GnRH signaling pathway_Homo sapiens_hsa049120.67396974
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65115580
65ABC transporters_Homo sapiens_hsa020100.63699940
66Salmonella infection_Homo sapiens_hsa051320.62451476
67Butanoate metabolism_Homo sapiens_hsa006500.60509315
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59499347
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59399752
70Chemical carcinogenesis_Homo sapiens_hsa052040.58675371
71Pyruvate metabolism_Homo sapiens_hsa006200.58658653
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58649236
73Allograft rejection_Homo sapiens_hsa053300.56311672
74Tyrosine metabolism_Homo sapiens_hsa003500.56268447
75Renin secretion_Homo sapiens_hsa049240.54631048
76Bladder cancer_Homo sapiens_hsa052190.53747958
77Ether lipid metabolism_Homo sapiens_hsa005650.53529571
78Peroxisome_Homo sapiens_hsa041460.52920418
79Thyroid cancer_Homo sapiens_hsa052160.52911547
80Autoimmune thyroid disease_Homo sapiens_hsa053200.52016015
81Gap junction_Homo sapiens_hsa045400.50960637
82Arginine and proline metabolism_Homo sapiens_hsa003300.50631507
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.48039924
84Hepatitis C_Homo sapiens_hsa051600.47761255
85Long-term potentiation_Homo sapiens_hsa047200.47539445
86Graft-versus-host disease_Homo sapiens_hsa053320.46866347
87Circadian entrainment_Homo sapiens_hsa047130.46811709
88African trypanosomiasis_Homo sapiens_hsa051430.46474287
89Insulin resistance_Homo sapiens_hsa049310.46074212
90Dorso-ventral axis formation_Homo sapiens_hsa043200.44934875
91Biosynthesis of amino acids_Homo sapiens_hsa012300.43779227
92Cocaine addiction_Homo sapiens_hsa050300.43484455
93Carbon metabolism_Homo sapiens_hsa012000.43330120
94Cardiac muscle contraction_Homo sapiens_hsa042600.43131556
95Choline metabolism in cancer_Homo sapiens_hsa052310.42935197
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.42478810
97Amphetamine addiction_Homo sapiens_hsa050310.41109534
98Long-term depression_Homo sapiens_hsa047300.40765130
99Alzheimers disease_Homo sapiens_hsa050100.40667497
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40638629
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40533646
102Arachidonic acid metabolism_Homo sapiens_hsa005900.40052291
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39379696
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.39320696
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.39296733
106Cholinergic synapse_Homo sapiens_hsa047250.37175627
107Fatty acid biosynthesis_Homo sapiens_hsa000610.36442768
108Type I diabetes mellitus_Homo sapiens_hsa049400.36340463
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36040305
110Glutamatergic synapse_Homo sapiens_hsa047240.36035575
111Pertussis_Homo sapiens_hsa051330.34076016
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.34057656
113VEGF signaling pathway_Homo sapiens_hsa043700.28139557
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27642378
115Estrogen signaling pathway_Homo sapiens_hsa049150.24969871
116Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24627425
117Oxidative phosphorylation_Homo sapiens_hsa001900.23771633
118Vibrio cholerae infection_Homo sapiens_hsa051100.22814315
119Glucagon signaling pathway_Homo sapiens_hsa049220.22696978
120Antigen processing and presentation_Homo sapiens_hsa046120.22521826
121Dopaminergic synapse_Homo sapiens_hsa047280.21880267
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21795707
123ErbB signaling pathway_Homo sapiens_hsa040120.21604040
124Metabolic pathways_Homo sapiens_hsa011000.20728521
125Leishmaniasis_Homo sapiens_hsa051400.20160274
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20144115
127Adherens junction_Homo sapiens_hsa045200.19352072
128Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18849380
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18807696
130Synaptic vesicle cycle_Homo sapiens_hsa047210.18344736
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15081492
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14840748
133N-Glycan biosynthesis_Homo sapiens_hsa005100.10217154
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.09804162
135Propanoate metabolism_Homo sapiens_hsa006400.08495069
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.07487713
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05378010
138AMPK signaling pathway_Homo sapiens_hsa041520.05091314
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.04664780
140Toxoplasmosis_Homo sapiens_hsa051450.04127295

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