EPX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1imidazole-containing compound metabolic process (GO:0052803)8.89312164
2leukocyte migration involved in inflammatory response (GO:0002523)8.64012677
3defense response to fungus (GO:0050832)8.51045889
4positive regulation of interleukin-8 biosynthetic process (GO:0045416)8.44957188
5leukocyte aggregation (GO:0070486)8.43687718
6superoxide anion generation (GO:0042554)8.27198261
7innate immune response in mucosa (GO:0002227)8.13408670
8antibacterial humoral response (GO:0019731)8.11486506
9antimicrobial humoral response (GO:0019730)7.46000059
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)7.21234468
11killing of cells in other organism involved in symbiotic interaction (GO:0051883)7.21234468
12response to fungus (GO:0009620)7.20000663
13neutrophil activation (GO:0042119)6.93307434
14mucosal immune response (GO:0002385)6.91251243
15sequestering of metal ion (GO:0051238)6.72926105
16respiratory burst (GO:0045730)6.58099777
17* negative regulation of interleukin-10 production (GO:0032693)6.53781220
18organ or tissue specific immune response (GO:0002251)6.49022992
19granulocyte activation (GO:0036230)6.47208710
20leukotriene metabolic process (GO:0006691)6.26874744
21response to peptidoglycan (GO:0032494)6.15133703
22leukotriene biosynthetic process (GO:0019370)5.92756464
23protoporphyrinogen IX metabolic process (GO:0046501)5.86989422
24regulation of dendritic cell antigen processing and presentation (GO:0002604)5.75622453
25regulation of interleukin-8 biosynthetic process (GO:0045414)5.67531493
26oxygen transport (GO:0015671)5.64969091
27reactive oxygen species biosynthetic process (GO:1903409)5.62645623
28negative regulation of interleukin-8 production (GO:0032717)5.52090919
29neutrophil mediated immunity (GO:0002446)5.47229011
30protoporphyrinogen IX biosynthetic process (GO:0006782)5.46788054
31killing of cells of other organism (GO:0031640)5.38755205
32disruption of cells of other organism (GO:0044364)5.38755205
33hydrogen peroxide biosynthetic process (GO:0050665)5.37083635
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.35390525
35negative regulation of cell killing (GO:0031342)5.35390525
36detection of other organism (GO:0098543)5.18799686
37chronic inflammatory response (GO:0002544)5.15786524
38regulation of female gonad development (GO:2000194)5.15492140
39gas transport (GO:0015669)4.77907634
40* positive regulation of interleukin-4 production (GO:0032753)4.77061944
41macrophage differentiation (GO:0030225)4.58607635
42negative regulation of phagocytosis (GO:0050765)4.56654393
43neutrophil activation involved in immune response (GO:0002283)4.55224169
44regulation of lipoprotein particle clearance (GO:0010984)4.51787696
45cellular extravasation (GO:0045123)4.40180483
46hemoglobin metabolic process (GO:0020027)4.38848444
47defense response to Gram-positive bacterium (GO:0050830)4.34144346
48myeloid dendritic cell differentiation (GO:0043011)4.28412794
49negative regulation of erythrocyte differentiation (GO:0045647)4.25110095
50regulation of T-helper 1 cell differentiation (GO:0045625)4.22928551
51regulation of myeloid leukocyte mediated immunity (GO:0002886)4.19972175
52myeloid leukocyte mediated immunity (GO:0002444)4.12832252
53positive regulation of antigen processing and presentation (GO:0002579)4.10479297
54positive regulation of gamma-delta T cell activation (GO:0046645)4.06568095
55negative regulation of interleukin-12 production (GO:0032695)4.03966591
56regulation of leukocyte degranulation (GO:0043300)4.02494830
57dendritic cell differentiation (GO:0097028)4.01389663
58intracellular estrogen receptor signaling pathway (GO:0030520)3.99278438
59positive regulation of B cell differentiation (GO:0045579)3.97702769
60peptide catabolic process (GO:0043171)3.93233953
61erythrocyte maturation (GO:0043249)3.91986557
62neutrophil chemotaxis (GO:0030593)3.86344711
63dendritic cell chemotaxis (GO:0002407)3.85062406
64mannose metabolic process (GO:0006013)3.84250791
65positive regulation of steroid hormone secretion (GO:2000833)3.82933729
66positive regulation of granulocyte differentiation (GO:0030854)3.81787610
67negative regulation of interleukin-6 production (GO:0032715)3.79396387
68pentose-phosphate shunt (GO:0006098)3.76531290
69neutrophil migration (GO:1990266)3.75402395
70porphyrin-containing compound biosynthetic process (GO:0006779)3.73999725
71myeloid dendritic cell activation (GO:0001773)3.73721118
72definitive hemopoiesis (GO:0060216)3.73595569
73superoxide metabolic process (GO:0006801)3.72864207
74myeloid cell development (GO:0061515)3.70469315
75defense response to bacterium (GO:0042742)3.65389831
76leukocyte mediated cytotoxicity (GO:0001909)3.62943913
77erythrocyte development (GO:0048821)3.59538612
78regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.59487209
79regulation of mast cell degranulation (GO:0043304)3.55141540
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.54835552
81positive regulation of mast cell degranulation (GO:0043306)3.54835552
82regulation of regulated secretory pathway (GO:1903305)3.54554155
83leukocyte cell-cell adhesion (GO:0007159)3.49510456
84regulation of interleukin-8 production (GO:0032677)3.48770630
85regulation of antigen processing and presentation (GO:0002577)3.44564130
86positive regulation of mast cell activation (GO:0033005)3.44464904
87regulation of tolerance induction (GO:0002643)3.44062875
88response to host immune response (GO:0052572)3.42079694
89response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.42079694
90positive regulation of Cdc42 GTPase activity (GO:0043089)3.40697682
91megakaryocyte development (GO:0035855)3.39216463
92detection of external biotic stimulus (GO:0098581)3.38605738
93positive regulation of T-helper 1 type immune response (GO:0002827)3.38111711
94response to methylmercury (GO:0051597)3.38008842
95NADPH regeneration (GO:0006740)3.34406032
96cellular biogenic amine biosynthetic process (GO:0042401)3.32341690
97amine biosynthetic process (GO:0009309)3.32341690
98negative regulation of granulocyte differentiation (GO:0030853)3.30988109
99dendritic cell migration (GO:0036336)3.30274252
100NIK/NF-kappaB signaling (GO:0038061)3.30220819
101regulation of mast cell activation involved in immune response (GO:0033006)3.28883804
102positive regulation of T-helper cell differentiation (GO:0045624)3.27603159
103positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.27365164
104cell killing (GO:0001906)3.26713769
105regulation of response to osmotic stress (GO:0047484)3.23602025
106* regulation of interleukin-4 production (GO:0032673)3.21569762
107response to bacterium (GO:0009617)3.20597608
108phagosome maturation (GO:0090382)3.20162437
109production of molecular mediator involved in inflammatory response (GO:0002532)3.19801866
110negative regulation of growth of symbiont in host (GO:0044130)3.18981983
111negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.18981983
112modulation of growth of symbiont involved in interaction with host (GO:0044144)3.18981983
113regulation of growth of symbiont in host (GO:0044126)3.18981983
114granulocyte chemotaxis (GO:0071621)3.18907523
115heme biosynthetic process (GO:0006783)3.18271404
116icosanoid biosynthetic process (GO:0046456)3.17992866
117fatty acid derivative biosynthetic process (GO:1901570)3.17992866
118detection of biotic stimulus (GO:0009595)3.17988069
119regulation of mast cell activation (GO:0033003)3.17068560
120tetrapyrrole biosynthetic process (GO:0033014)3.16994912
121adaptation of signaling pathway (GO:0023058)3.14409447
122Arp2/3 complex-mediated actin nucleation (GO:0034314)3.11183715
123* granulocyte migration (GO:0097530)3.10845874
124positive regulation of interleukin-8 production (GO:0032757)3.10813559
125positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.10074959
126modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.09445345
127modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.09445345
128positive regulation by organism of defense response of other organism involved in symbiotic interact3.09445345
129modulation by symbiont of host immune response (GO:0052553)3.09445345
130positive regulation by symbiont of host defense response (GO:0052509)3.09445345
131modulation by symbiont of host defense response (GO:0052031)3.09445345
132* hydrogen peroxide catabolic process (GO:0042744)3.08498490
133positive regulation of granulocyte chemotaxis (GO:0071624)3.05153133
134response to muramyl dipeptide (GO:0032495)3.02769910
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02282171
136response to host (GO:0075136)3.02282171
137response to host defenses (GO:0052200)3.02282171
138positive regulation of neutrophil chemotaxis (GO:0090023)3.01826373
139positive regulation of neutrophil migration (GO:1902624)3.01826373
140citrulline biosynthetic process (GO:0019240)3.00446285
141phospholipid homeostasis (GO:0055091)2.98185764
142negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96305432
143detection of bacterium (GO:0016045)2.96142948
144regulation of T cell tolerance induction (GO:0002664)2.95384995
1453-UTR-mediated mRNA stabilization (GO:0070935)2.93849709
146regulation of granulocyte differentiation (GO:0030852)2.93457881
147regulation of macrophage cytokine production (GO:0010935)2.91941145
148myeloid leukocyte activation (GO:0002274)2.90855121
149positive regulation of regulated secretory pathway (GO:1903307)2.88139344
150porphyrin-containing compound metabolic process (GO:0006778)2.80687413
151positive regulation of cytokine biosynthetic process (GO:0042108)2.80301757
152activated T cell proliferation (GO:0050798)2.77337212
153regulation of gamma-delta T cell differentiation (GO:0045586)2.77296222
154regulation of gamma-delta T cell activation (GO:0046643)2.75058972
155regulation of B cell differentiation (GO:0045577)2.74542623

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYB_21317192_ChIP-Seq_ERMYB_Mouse4.92515546
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.76322272
3E2F7_22180533_ChIP-Seq_HELA_Human4.53138282
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.92901423
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.72221202
6VDR_21846776_ChIP-Seq_THP-1_Human3.58745126
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.30787679
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.26220267
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.18842381
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.05503950
11BRD4_27068464_Chip-Seq_AML-cells_Mouse3.02147568
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93105619
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.89120326
14SCL_19346495_ChIP-Seq_HPC-7_Human2.75024259
15VDR_24763502_ChIP-Seq_THP-1_Human2.69445218
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.66501924
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65005740
18MYC_22102868_ChIP-Seq_BL_Human2.45192433
19SPI1_23547873_ChIP-Seq_NB4_Human2.40147474
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39350722
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30249809
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.23837790
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23483469
24TCF7_22412390_ChIP-Seq_EML_Mouse2.22331465
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18007788
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.12494612
27UTX_26944678_Chip-Seq_JUKART_Human2.11177576
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11021741
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09096836
30MAF_26560356_Chip-Seq_TH1_Human2.08147711
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07912812
32SPI1_23127762_ChIP-Seq_K562_Human1.99813768
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95511844
34MYB_26560356_Chip-Seq_TH2_Human1.88863519
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.81834510
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77218793
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74084386
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73231589
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72156563
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71937597
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66652298
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.65072083
43GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.62173024
44PU_27001747_Chip-Seq_BMDM_Mouse1.60472018
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59146408
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59018089
47RUNX_20019798_ChIP-Seq_JUKART_Human1.57761133
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57074627
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57002494
50MYB_26560356_Chip-Seq_TH1_Human1.54884986
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54403156
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52363771
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.43468092
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42365630
55KDM2B_26808549_Chip-Seq_DND41_Human1.41946414
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.40578871
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39842178
58LXR_22292898_ChIP-Seq_THP-1_Human1.35629004
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.34473258
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29607105
61GATA1_19941826_ChIP-Seq_K562_Human1.28777873
62MAF_26560356_Chip-Seq_TH2_Human1.28750084
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28617147
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28063439
65VDR_24787735_ChIP-Seq_THP-1_Human1.27385787
66EGR1_19032775_ChIP-ChIP_M12_Human1.27360383
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26925089
68GATA1_22025678_ChIP-Seq_K562_Human1.26579816
69GATA3_27048872_Chip-Seq_THYMUS_Human1.24731800
70GATA2_19941826_ChIP-Seq_K562_Human1.23892969
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20411267
72SPI1_20517297_ChIP-Seq_HL60_Human1.20366221
73* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19040229
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18773135
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18489781
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18375397
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14741798
78RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14402002
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13794572
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.12511648
81BCL6_27268052_Chip-Seq_Bcells_Human1.12469670
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11191915
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10319592
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.09818845
85RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09734572
86BCOR_27268052_Chip-Seq_Bcells_Human1.06058779
87PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04525354
88NCOR1_26117541_ChIP-Seq_K562_Human1.03318448
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.03103941
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02682796
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.02147405
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01775367
93GATA3_26560356_Chip-Seq_TH2_Human1.01294005
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00358544
95GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00141026
96RACK7_27058665_Chip-Seq_MCF-7_Human0.97711793
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97550170
98GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95722979
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95720371
100CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95355839
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95351610
102ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95134925
103ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93158348
104STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93082450
105PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92451750
106STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92272002
107GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92034840
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88886242
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86322311
110P300_27268052_Chip-Seq_Bcells_Human0.85283058
111AR_21909140_ChIP-Seq_LNCAP_Human0.84838465
112IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.84658846
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83891667
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83232377
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82385289
116P68_20966046_ChIP-Seq_HELA_Human0.80474354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation6.13456726
2MP0004147_increased_porphyrin_level4.27324786
3MP0003183_abnormal_peptide_metabolism4.10016712
4MP0003436_decreased_susceptibility_to3.99147882
5MP0000685_abnormal_immune_system3.58074042
6MP0009785_altered_susceptibility_to3.39401509
7MP0009278_abnormal_bone_marrow3.35332136
8MP0004510_myositis2.99937296
9MP0002419_abnormal_innate_immunity2.99395598
10MP0005058_abnormal_lysosome_morphology2.99170442
11MP0001835_abnormal_antigen_presentation2.80036600
12MP0002009_preneoplasia2.77170509
13MP0005025_abnormal_response_to2.71233432
14MP0005464_abnormal_platelet_physiology2.64927351
15MP0002405_respiratory_system_inflammati2.58728423
16MP0002877_abnormal_melanocyte_morpholog2.55155744
17MP0003300_gastrointestinal_ulcer2.48990095
18MP0001851_eye_inflammation2.30550878
19MP0005000_abnormal_immune_tolerance2.30078040
20MP0000343_altered_response_to2.23627089
21MP0001853_heart_inflammation2.22625807
22MP0001533_abnormal_skeleton_physiology2.16278498
23MP0003724_increased_susceptibility_to2.10461560
24MP0001545_abnormal_hematopoietic_system2.09817249
25MP0005397_hematopoietic_system_phenotyp2.09817249
26MP0001800_abnormal_humoral_immune2.01866099
27MP0002420_abnormal_adaptive_immunity1.95580833
28MP0001819_abnormal_immune_cell1.93737152
29MP0002452_abnormal_antigen_presenting1.92160949
30MP0001845_abnormal_inflammatory_respons1.92137524
31MP0000465_gastrointestinal_hemorrhage1.90703401
32MP0005645_abnormal_hypothalamus_physiol1.90292963
33MP0005387_immune_system_phenotype1.87853257
34MP0001790_abnormal_immune_system1.87853257
35MP0002148_abnormal_hypersensitivity_rea1.85217045
36MP0005310_abnormal_salivary_gland1.82656527
37MP0002723_abnormal_immune_serum1.82208216
38MP0005671_abnormal_response_to1.76573493
39MP0005083_abnormal_biliary_tract1.73356298
40MP0002876_abnormal_thyroid_physiology1.72410610
41MP0002735_abnormal_chemical_nociception1.69016987
42MP0002166_altered_tumor_susceptibility1.66590654
43* MP0002398_abnormal_bone_marrow1.65298690
44MP0002396_abnormal_hematopoietic_system1.64890028
45MP0009764_decreased_sensitivity_to1.59406722
46* MP0000716_abnormal_immune_system1.56755415
47MP0003172_abnormal_lysosome_physiology1.54004277
48MP0010155_abnormal_intestine_physiology1.51708257
49MP0004808_abnormal_hematopoietic_stem1.49288316
50MP0006082_CNS_inflammation1.49187365
51MP0008260_abnormal_autophagy1.47458405
52MP0003656_abnormal_erythrocyte_physiolo1.37715079
53MP0005409_darkened_coat_color1.37365201
54* MP0002429_abnormal_blood_cell1.34158656
55MP0008057_abnormal_DNA_replication1.32997101
56MP0008469_abnormal_protein_level1.31167696
57MP0004947_skin_inflammation1.25960789
58MP0004185_abnormal_adipocyte_glucose1.24945825
59MP0010352_gastrointestinal_tract_polyps1.23455309
60MP0003075_altered_response_to1.22615248
61MP0000015_abnormal_ear_pigmentation1.20121306
62MP0009333_abnormal_splenocyte_physiolog1.20102496
63MP0002722_abnormal_immune_system1.17682099
64MP0005076_abnormal_cell_differentiation1.16866241
65MP0002254_reproductive_system_inflammat1.16556471
66MP0003566_abnormal_cell_adhesion1.14848718
67MP0000858_altered_metastatic_potential1.12668627
68MP0003806_abnormal_nucleotide_metabolis1.11954634
69MP0000689_abnormal_spleen_morphology1.11672923
70MP0001986_abnormal_taste_sensitivity1.11383436
71MP0004883_abnormal_blood_vessel1.11158579
72MP0009840_abnormal_foam_cell1.08525734
73MP0010307_abnormal_tumor_latency1.06824209
74MP0001873_stomach_inflammation1.05840654
75MP0005075_abnormal_melanosome_morpholog1.02901234
76MP0001764_abnormal_homeostasis1.02635168
77MP0003448_altered_tumor_morphology0.98607399
78MP0009765_abnormal_xenobiotic_induced0.96614738
79MP0005451_abnormal_body_composition0.96220320
80MP0001663_abnormal_digestive_system0.96143632
81MP0003045_fibrosis0.96107374
82MP0005164_abnormal_response_to0.95649137
83MP0008874_decreased_physiological_sensi0.95427676
84MP0001348_abnormal_lacrimal_gland0.94394794
85MP0003221_abnormal_cardiomyocyte_apopto0.94091161
86MP0002006_tumorigenesis0.93431269
87MP0003828_pulmonary_edema0.92897399
88MP0002971_abnormal_brown_adipose0.92753992
89MP0002998_abnormal_bone_remodeling0.90516029
90MP0009115_abnormal_fat_cell0.90156494
91MP0003279_aneurysm0.88257047
92MP0003638_abnormal_response/metabolism_0.87436121
93MP0004264_abnormal_extraembryonic_tissu0.87403576
94MP0002282_abnormal_trachea_morphology0.87272079
95MP0003111_abnormal_nucleus_morphology0.85630693
96MP0009931_abnormal_skin_appearance0.83081296
97MP0009763_increased_sensitivity_to0.81748380
98MP0002277_abnormal_respiratory_mucosa0.80513719
99MP0000703_abnormal_thymus_morphology0.80198354
100MP0005390_skeleton_phenotype0.79378811
101MP0005666_abnormal_adipose_tissue0.78826636
102MP0002837_dystrophic_cardiac_calcinosis0.78707442
103MP0002928_abnormal_bile_duct0.75749616
104MP0000604_amyloidosis0.75435866
105MP0002095_abnormal_skin_pigmentation0.74872519
106MP0003795_abnormal_bone_structure0.72129137
107MP0008995_early_reproductive_senescence0.71819545
108MP0000003_abnormal_adipose_tissue0.70006858
109MP0003453_abnormal_keratinocyte_physiol0.69654414
110MP0000920_abnormal_myelination0.69086258
111MP0002970_abnormal_white_adipose0.68477500
112MP0005621_abnormal_cell_physiology0.67596333
113MP0002019_abnormal_tumor_incidence0.67355637
114MP0003866_abnormal_defecation0.67140855
115MP0003959_abnormal_lean_body0.66929383
116MP0002933_joint_inflammation0.66804137
117MP0005023_abnormal_wound_healing0.65880236
118MP0000598_abnormal_liver_morphology0.65402292
119MP0000249_abnormal_blood_vessel0.64369390
120MP0003191_abnormal_cellular_cholesterol0.63569360
121MP0005167_abnormal_blood-brain_barrier0.61509736
122MP0008007_abnormal_cellular_replicative0.61037858
123MP0005174_abnormal_tail_pigmentation0.60591500
124MP0000609_abnormal_liver_physiology0.59121719
125MP0003693_abnormal_embryo_hatching0.58016063
126MP0006054_spinal_hemorrhage0.57700374
127MP0005381_digestive/alimentary_phenotyp0.56933567
128MP0001915_intracranial_hemorrhage0.56077508
129MP0003705_abnormal_hypodermis_morpholog0.55724980
130MP0003763_abnormal_thymus_physiology0.54685870
131MP0002132_abnormal_respiratory_system0.54643054
132MP0008961_abnormal_basal_metabolism0.54396474
133MP0005334_abnormal_fat_pad0.53315378

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)9.47034711
2Recurrent abscess formation (HP:0002722)8.60262677
3Recurrent gram-negative bacterial infections (HP:0005420)8.56265928
4Recurrent bacterial skin infections (HP:0005406)8.22768712
5Abnormality of the heme biosynthetic pathway (HP:0010472)7.81667139
6Hypochromic microcytic anemia (HP:0004840)7.41676445
7Obstructive lung disease (HP:0006536)6.16680027
8Chronic obstructive pulmonary disease (HP:0006510)6.16680027
9Recurrent skin infections (HP:0001581)5.56841756
10Recurrent fungal infections (HP:0002841)5.48319013
11Abnormality of macrophages (HP:0004311)5.33648746
12Mediastinal lymphadenopathy (HP:0100721)5.31082005
13Cellulitis (HP:0100658)4.90913905
14Gingivitis (HP:0000230)4.87582800
15Hypochromic anemia (HP:0001931)4.50083685
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.43756667
17Recurrent cutaneous fungal infections (HP:0011370)4.32249738
18Chronic mucocutaneous candidiasis (HP:0002728)4.32249738
19Urticaria (HP:0001025)4.30630187
20Increased cerebral lipofuscin (HP:0011813)4.29436372
21Microcytic anemia (HP:0001935)3.96634296
22Meningitis (HP:0001287)3.91269119
23Stomatitis (HP:0010280)3.79506225
24Polycythemia (HP:0001901)3.78890907
25Increased IgE level (HP:0003212)3.73264506
26Recurrent pneumonia (HP:0006532)3.47323820
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.37588552
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.24697099
29Myositis (HP:0100614)3.24636345
30Paralysis (HP:0003470)3.21710607
31Petechiae (HP:0000967)3.15167435
32Abnormal hemoglobin (HP:0011902)3.14544443
33Cholelithiasis (HP:0001081)3.13921746
34Papilledema (HP:0001085)3.13900935
35Increased density of long bones (HP:0006392)3.10727449
36Periodontitis (HP:0000704)3.08483122
37Dysostosis multiplex (HP:0000943)3.03233814
38Interstitial pulmonary disease (HP:0006530)2.96017809
39Impaired platelet aggregation (HP:0003540)2.95598217
40Abnormal platelet function (HP:0011869)2.95598217
41Abnormality of liposaccharide metabolism (HP:0010968)2.95137187
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.95137187
43Abnormality of glycolipid metabolism (HP:0010969)2.95137187
44Recurrent lower respiratory tract infections (HP:0002783)2.90775409
45Thrombocytosis (HP:0001894)2.90582587
46Abnormality of the fingertips (HP:0001211)2.87834066
47Vasculitis (HP:0002633)2.83807596
48Chest pain (HP:0100749)2.82464598
49Osteomyelitis (HP:0002754)2.82220007
50Gingival bleeding (HP:0000225)2.82160370
51Autoimmune thrombocytopenia (HP:0001973)2.81268595
52Recurrent viral infections (HP:0004429)2.80701174
53Abnormal platelet volume (HP:0011876)2.80328653
54Abnormal gallbladder morphology (HP:0012437)2.77183310
55Inflammation of the large intestine (HP:0002037)2.75607908
56Prolonged bleeding time (HP:0003010)2.73632682
57Spontaneous hematomas (HP:0007420)2.73356158
58Toxemia of pregnancy (HP:0100603)2.73179858
59Epistaxis (HP:0000421)2.69257405
60Sepsis (HP:0100806)2.68940946
61Gastrointestinal inflammation (HP:0004386)2.67056378
62Diaphragmatic weakness (HP:0009113)2.61472339
63Acute myeloid leukemia (HP:0004808)2.60502846
64Elevated erythrocyte sedimentation rate (HP:0003565)2.55073566
65Gastrointestinal stroma tumor (HP:0100723)2.53215324
66Acute lymphatic leukemia (HP:0006721)2.52892041
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51982928
68Abnormality of polysaccharide metabolism (HP:0011012)2.51982928
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51982928
70Colitis (HP:0002583)2.49863441
71Annular pancreas (HP:0001734)2.47704385
72Thoracic kyphosis (HP:0002942)2.47571433
73Reticulocytosis (HP:0001923)2.45089211
74Upper motor neuron abnormality (HP:0002127)2.42482234
75Nonimmune hydrops fetalis (HP:0001790)2.41697242
76Vacuolated lymphocytes (HP:0001922)2.39715888
77Mucopolysacchariduria (HP:0008155)2.37635911
78Urinary glycosaminoglycan excretion (HP:0003541)2.37635911
79Hepatosplenomegaly (HP:0001433)2.34508337
80Increased mean platelet volume (HP:0011877)2.33983441
81Leukocytosis (HP:0001974)2.31579223
82Pustule (HP:0200039)2.28503577
83Restrictive lung disease (HP:0002091)2.28031313
84Skin ulcer (HP:0200042)2.26199999
85Episodic fever (HP:0001954)2.23700413
86Abnormality of T cell physiology (HP:0011840)2.23039381
87Chronic otitis media (HP:0000389)2.22729155
88Hemoptysis (HP:0002105)2.20839439
89Purpura (HP:0000979)2.20314579
90IgM deficiency (HP:0002850)2.17539968
91Orchitis (HP:0100796)2.15695070
92Systemic lupus erythematosus (HP:0002725)2.15500831
93Cheilitis (HP:0100825)2.14804257
94Arterial thrombosis (HP:0004420)2.14387895
95Poikilocytosis (HP:0004447)2.14135256
96Verrucae (HP:0200043)2.13297182
97Papilloma (HP:0012740)2.13297182
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.13136167
99Peritonitis (HP:0002586)2.07290195
100Menorrhagia (HP:0000132)2.07132784
101Abnormality of the thoracic spine (HP:0100711)2.04784832
102Lymphopenia (HP:0001888)2.04556195
103Aplasia/Hypoplasia of the spleen (HP:0010451)2.02502265
104Cutaneous photosensitivity (HP:0000992)1.99722350
105Agammaglobulinemia (HP:0004432)1.99379599
106Pulmonary embolism (HP:0002204)1.99234771
107Abnormality of the lumbar spine (HP:0100712)1.98993714
108Abnormality of the gallbladder (HP:0005264)1.98907046
109Acanthocytosis (HP:0001927)1.97411074
110Hematochezia (HP:0002573)1.96848021
111Hypermelanotic macule (HP:0001034)1.95511832
112Granulocytopenia (HP:0001913)1.94138840
113Prolonged neonatal jaundice (HP:0006579)1.93874971
114Abnormality of transition element cation homeostasis (HP:0011030)1.92681198
115Slender build (HP:0001533)1.90823801
116Pallor (HP:0000980)1.90678403
117Abnormality of binocular vision (HP:0011514)1.89181549
118Diplopia (HP:0000651)1.89181549
119Eosinophilia (HP:0001880)1.87939199
120Pulmonary infiltrates (HP:0002113)1.87798865
121Paresthesia (HP:0003401)1.84916727
122Abnormality of reticulocytes (HP:0004312)1.84286808
123Amaurosis fugax (HP:0100576)1.83926994
124Encephalitis (HP:0002383)1.81177826
125Abnormality of B cell number (HP:0010975)1.80846653
126Hypergammaglobulinemia (HP:0010702)1.78508377
127Poikiloderma (HP:0001029)1.76756134
128Keratoconjunctivitis (HP:0001096)1.75968092
129Amyloidosis (HP:0011034)1.75145649
130Gastrointestinal infarctions (HP:0005244)1.71758213
131Thyroiditis (HP:0100646)1.70355251
132Pyloric stenosis (HP:0002021)1.67677296
133Emphysema (HP:0002097)1.65595003
134Joint hemorrhage (HP:0005261)1.65029974
135Panhypogammaglobulinemia (HP:0003139)1.64644116
136Abnormality of the prostate (HP:0008775)1.64200003
137Thrombophlebitis (HP:0004418)1.60737984
138Abnormality of iron homeostasis (HP:0011031)1.60292295
139Acrocyanosis (HP:0001063)1.59993855
140Increased serum ferritin (HP:0003281)1.59723539
141Abnormality of the common coagulation pathway (HP:0010990)1.59172849
142Abnormality of T cells (HP:0002843)1.56408136
143Recurrent sinusitis (HP:0011108)1.56163724
144Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.55444114
145Retrobulbar optic neuritis (HP:0100654)1.51393736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK46.31524127
2PRPF4B3.81494832
3EPHB13.42353609
4RIPK43.16119054
5ERN12.73261166
6GRK62.64893284
7MAP3K142.52427886
8BLK2.49608878
9MAP4K12.47548726
10FES2.44309635
11IRAK32.43226166
12ALK2.33453059
13BTK2.21569309
14TRIB32.21449701
15CLK12.13130112
16EEF2K2.03819390
17PIK3CG1.98688569
18PRKG21.94701026
19STK101.92224649
20PTK61.91260451
21CSK1.91215801
22TTN1.87994768
23TYK21.70521612
24LRRK21.60311461
25HCK1.57202497
26MAP3K131.55455472
27TAOK21.55127539
28PKN21.49193060
29FGR1.47234678
30TBK11.42985086
31MAP3K31.41986434
32MAP3K121.41276912
33PAK41.28345835
34KSR21.28224341
35MAP2K31.27437313
36MAP3K61.27364735
37SYK1.27232584
38TESK21.26085882
39HIPK21.22811938
40MAPK41.17504080
41PIK3CA1.15802138
42IKBKE1.10519794
43ZAP701.08945783
44SIK21.05381403
45TESK10.99147011
46CAMK1G0.99084459
47TRPM70.98764889
48PIM10.98486699
49BMX0.98306624
50MAP3K110.96738700
51JAK20.96061837
52TAOK30.94167463
53TEC0.93773946
54ITK0.89770504
55IKBKB0.85971804
56RAF10.83748497
57LYN0.82596647
58KIT0.81524728
59PRKAA20.81144350
60MAP3K90.80941440
61RPS6KA40.80841799
62MAPK120.80621951
63PDPK10.78733157
64NEK20.78074203
65PDK10.74485902
66PTK2B0.70670818
67DAPK20.70359359
68CSF1R0.67994486
69JAK30.67711745
70MAP2K40.67597419
71BRD40.66393122
72MAP3K50.65456820
73PRKCD0.64550144
74LCK0.64467741
75MAP3K80.63742467
76MARK20.63394097
77EIF2AK10.62386973
78SIK30.62220053
79MAPK70.59958284
80MAPKAPK20.59640409
81JAK10.58246970
82RPS6KA20.58246309
83PIM20.56165769
84WNK10.56110868
85MARK30.55726959
86KDR0.54918882
87MATK0.53299378
88MAP3K70.52090872
89EGFR0.50599457
90CDK190.50299403
91RPS6KB20.49497444
92ILK0.49481907
93MAP3K100.47952007
94RET0.47456233
95CDK120.47336301
96TAOK10.46986283
97FYN0.46856298
98RPS6KA10.46167572
99DMPK0.45664162
100TGFBR20.45310216
101PTK20.44868804
102MAP2K10.44132021
103MAP2K20.43793714
104PLK40.42023590
105SGK30.41109845
106MAPK30.40469183
107FLT30.40361057
108STK110.38185832
109TXK0.37786641
110RPS6KL10.37636157
111RPS6KC10.37636157
112CHUK0.37016335
113RPS6KA60.35295917
114MAP3K10.34553766
115STK40.34494509
116LIMK10.34086170
117AKT10.33766325
118TNK20.33729694
119MOS0.33157883
120MTOR0.32567686
121MAPK110.30494942
122PRKACG0.29648120
123CDK60.28413640
124PRKCH0.28150450
125FGFR30.25919795
126CDK40.25860530
127SRC0.25324667
128STK240.24994017
129CAMK1D0.24742773
130PRKCQ0.24578781
131YES10.24189574
132BMPR20.23165258

Predicted pathways (KEGG)

RankGene SetZ-score
1* Asthma_Homo sapiens_hsa053106.52365354
2Leishmaniasis_Homo sapiens_hsa051404.38632659
3Other glycan degradation_Homo sapiens_hsa005113.45830237
4Osteoclast differentiation_Homo sapiens_hsa043803.03910214
5Staphylococcus aureus infection_Homo sapiens_hsa051502.84910181
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.76969428
7Leukocyte transendothelial migration_Homo sapiens_hsa046702.37964402
8Tuberculosis_Homo sapiens_hsa051522.07226827
9B cell receptor signaling pathway_Homo sapiens_hsa046622.03558311
10Chemokine signaling pathway_Homo sapiens_hsa040622.03288513
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.02734992
12Hematopoietic cell lineage_Homo sapiens_hsa046401.85279538
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.82138089
14Histidine metabolism_Homo sapiens_hsa003401.79718178
15Legionellosis_Homo sapiens_hsa051341.72204750
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.66531683
17Pertussis_Homo sapiens_hsa051331.65267892
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54975873
19Toxoplasmosis_Homo sapiens_hsa051451.54869821
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54594938
21Acute myeloid leukemia_Homo sapiens_hsa052211.53161939
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51949945
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51735921
24Shigellosis_Homo sapiens_hsa051311.50050178
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48611195
26Platelet activation_Homo sapiens_hsa046111.41708872
27Primary immunodeficiency_Homo sapiens_hsa053401.41561834
28Phagosome_Homo sapiens_hsa041451.40357517
29Pentose phosphate pathway_Homo sapiens_hsa000301.40021349
30VEGF signaling pathway_Homo sapiens_hsa043701.38704548
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.31576551
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31024790
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28120139
34Malaria_Homo sapiens_hsa051441.23638191
35Salmonella infection_Homo sapiens_hsa051321.21745911
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.21248261
37Chronic myeloid leukemia_Homo sapiens_hsa052201.20969029
38Pancreatic cancer_Homo sapiens_hsa052121.19599176
39Hepatitis B_Homo sapiens_hsa051611.12849654
40Amoebiasis_Homo sapiens_hsa051461.06970368
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03104096
42Apoptosis_Homo sapiens_hsa042101.02839357
43Measles_Homo sapiens_hsa051621.00052116
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97527615
45TNF signaling pathway_Homo sapiens_hsa046680.96977216
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96712464
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96565983
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96124023
49Renin-angiotensin system_Homo sapiens_hsa046140.93271798
50Antigen processing and presentation_Homo sapiens_hsa046120.91885783
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88406951
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88402393
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88367907
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87180022
55Influenza A_Homo sapiens_hsa051640.85058420
56Non-small cell lung cancer_Homo sapiens_hsa052230.83174486
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.76172296
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.75675143
59Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75654419
60MAPK signaling pathway_Homo sapiens_hsa040100.74956051
61African trypanosomiasis_Homo sapiens_hsa051430.72737761
62Dorso-ventral axis formation_Homo sapiens_hsa043200.69111931
63GnRH signaling pathway_Homo sapiens_hsa049120.68813301
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68657776
65Insulin resistance_Homo sapiens_hsa049310.67689290
66Allograft rejection_Homo sapiens_hsa053300.65471426
67Rap1 signaling pathway_Homo sapiens_hsa040150.64793548
68Choline metabolism in cancer_Homo sapiens_hsa052310.64550150
69ABC transporters_Homo sapiens_hsa020100.62066491
70Herpes simplex infection_Homo sapiens_hsa051680.61882153
71Viral carcinogenesis_Homo sapiens_hsa052030.61553124
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60946950
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60128818
74Hepatitis C_Homo sapiens_hsa051600.55340232
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55235535
76Autoimmune thyroid disease_Homo sapiens_hsa053200.55098593
77Graft-versus-host disease_Homo sapiens_hsa053320.55047842
78mTOR signaling pathway_Homo sapiens_hsa041500.54694678
79T cell receptor signaling pathway_Homo sapiens_hsa046600.54689383
80Prolactin signaling pathway_Homo sapiens_hsa049170.53964338
81Rheumatoid arthritis_Homo sapiens_hsa053230.51727397
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51165388
83Viral myocarditis_Homo sapiens_hsa054160.50395939
84Inositol phosphate metabolism_Homo sapiens_hsa005620.50219517
85HTLV-I infection_Homo sapiens_hsa051660.49436807
86Galactose metabolism_Homo sapiens_hsa000520.48865194
87Glioma_Homo sapiens_hsa052140.48190929
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.47689415
89Collecting duct acid secretion_Homo sapiens_hsa049660.47023318
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46829419
91Lysosome_Homo sapiens_hsa041420.45739902
92Prostate cancer_Homo sapiens_hsa052150.45591180
93Estrogen signaling pathway_Homo sapiens_hsa049150.45555350
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.44944432
95Proteoglycans in cancer_Homo sapiens_hsa052050.44568135
96Epstein-Barr virus infection_Homo sapiens_hsa051690.42013822
97MicroRNAs in cancer_Homo sapiens_hsa052060.41940522
98Base excision repair_Homo sapiens_hsa034100.40588820
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39162700
100Type II diabetes mellitus_Homo sapiens_hsa049300.38719569
101Notch signaling pathway_Homo sapiens_hsa043300.37651928
102Long-term potentiation_Homo sapiens_hsa047200.36754593
103Complement and coagulation cascades_Homo sapiens_hsa046100.36640821
104Endocytosis_Homo sapiens_hsa041440.36606563
105Melanoma_Homo sapiens_hsa052180.34664285
106Renal cell carcinoma_Homo sapiens_hsa052110.34302293
107Small cell lung cancer_Homo sapiens_hsa052220.34119681
108FoxO signaling pathway_Homo sapiens_hsa040680.33489998
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33237532
110Glycerolipid metabolism_Homo sapiens_hsa005610.33168798
111Pathways in cancer_Homo sapiens_hsa052000.32719258
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32030593
113Colorectal cancer_Homo sapiens_hsa052100.30849006
114DNA replication_Homo sapiens_hsa030300.29955511
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.28153021
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26704776
117Bladder cancer_Homo sapiens_hsa052190.26448056
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.26342569
119Nitrogen metabolism_Homo sapiens_hsa009100.25589622
120HIF-1 signaling pathway_Homo sapiens_hsa040660.24873817
121p53 signaling pathway_Homo sapiens_hsa041150.23784933
122Starch and sucrose metabolism_Homo sapiens_hsa005000.23652036
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23009072

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