ERAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)4.63398283
2DNA deamination (GO:0045006)4.49349657
3establishment of integrated proviral latency (GO:0075713)4.47958084
4DNA strand elongation involved in DNA replication (GO:0006271)4.29655651
5telomere maintenance via recombination (GO:0000722)4.18606252
6DNA strand elongation (GO:0022616)4.10392569
7non-recombinational repair (GO:0000726)4.00623335
8double-strand break repair via nonhomologous end joining (GO:0006303)4.00623335
9DNA replication initiation (GO:0006270)3.95760592
10cullin deneddylation (GO:0010388)3.91395022
11nucleobase biosynthetic process (GO:0046112)3.91230591
12proteasome assembly (GO:0043248)3.81264504
13establishment of viral latency (GO:0019043)3.78598912
14protein deneddylation (GO:0000338)3.77666999
15viral mRNA export from host cell nucleus (GO:0046784)3.77585534
16mitotic recombination (GO:0006312)3.75479602
17mitochondrial RNA metabolic process (GO:0000959)3.75116164
18purine nucleobase biosynthetic process (GO:0009113)3.74750368
19L-serine metabolic process (GO:0006563)3.70376705
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.68301657
21telomere maintenance via telomere lengthening (GO:0010833)3.67786522
22positive regulation of chromosome segregation (GO:0051984)3.63951427
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56957606
24tRNA aminoacylation for protein translation (GO:0006418)3.56718082
25folic acid-containing compound biosynthetic process (GO:0009396)3.54149181
26mitotic sister chromatid segregation (GO:0000070)3.53835874
27amino acid activation (GO:0043038)3.51644659
28tRNA aminoacylation (GO:0043039)3.51644659
29regulation of ubiquitin-protein transferase activity (GO:0051438)3.51333681
30positive regulation of mitotic sister chromatid separation (GO:1901970)3.48145883
31positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.48145883
32positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.48145883
33DNA replication checkpoint (GO:0000076)3.46252957
34tricarboxylic acid cycle (GO:0006099)3.46119585
35regulation of sister chromatid cohesion (GO:0007063)3.43223515
36regulation of ligase activity (GO:0051340)3.37288578
37chaperone-mediated protein transport (GO:0072321)3.36988846
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34670743
39rRNA modification (GO:0000154)3.32986582
40protein maturation by protein folding (GO:0022417)3.29713146
41oxidative phosphorylation (GO:0006119)3.28420322
42metaphase plate congression (GO:0051310)3.27826290
43IMP biosynthetic process (GO:0006188)3.27221243
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26072235
45protein targeting to mitochondrion (GO:0006626)3.24586405
46ribosome biogenesis (GO:0042254)3.24362712
47DNA-dependent DNA replication (GO:0006261)3.20132958
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19193845
49positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18901279
50postreplication repair (GO:0006301)3.16519131
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.15784429
52DNA ligation (GO:0006266)3.15338625
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.15093804
54establishment of protein localization to mitochondrial membrane (GO:0090151)3.14238545
55formation of translation preinitiation complex (GO:0001731)3.13955920
56maturation of SSU-rRNA (GO:0030490)3.10698006
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.10151190
58sister chromatid segregation (GO:0000819)3.09119673
59translesion synthesis (GO:0019985)3.08740310
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06840707
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.06727596
62termination of RNA polymerase III transcription (GO:0006386)3.06727596
63rRNA methylation (GO:0031167)3.06436875
64negative regulation of protein ubiquitination (GO:0031397)3.06245750
65transcription-coupled nucleotide-excision repair (GO:0006283)3.04983114
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03977502
67regulation of spindle organization (GO:0090224)3.03530592
68respiratory chain complex IV assembly (GO:0008535)3.03240001
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03072417
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03072417
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03072417
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03046475
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03046475
74attachment of spindle microtubules to kinetochore (GO:0008608)2.99921373
75regulation of cellular amine metabolic process (GO:0033238)2.99756150
76CENP-A containing nucleosome assembly (GO:0034080)2.99227567
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98219834
78heme biosynthetic process (GO:0006783)2.97208337
79pseudouridine synthesis (GO:0001522)2.96754208
80folic acid metabolic process (GO:0046655)2.96461408
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96408973
82negative regulation of ligase activity (GO:0051352)2.96408973
83spindle checkpoint (GO:0031577)2.96365499
84telomere maintenance (GO:0000723)2.96351483
85telomere organization (GO:0032200)2.95031292
86signal transduction involved in DNA damage checkpoint (GO:0072422)2.94590129
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94590129
88spliceosomal snRNP assembly (GO:0000387)2.94242629
89regulation of mitotic spindle organization (GO:0060236)2.93778228
90signal transduction involved in cell cycle checkpoint (GO:0072395)2.92879363
91maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92359785
92establishment of protein localization to mitochondrion (GO:0072655)2.92013210
93negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.91845709
94transcription from mitochondrial promoter (GO:0006390)2.89365043
95regulation of mitochondrial translation (GO:0070129)2.88531988
96pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.88525402
97mitotic spindle checkpoint (GO:0071174)2.87437626
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.87437098
99protoporphyrinogen IX biosynthetic process (GO:0006782)2.87110260
100DNA catabolic process, exonucleolytic (GO:0000738)2.86134952
101protein localization to mitochondrion (GO:0070585)2.85766777
102protein localization to chromosome, centromeric region (GO:0071459)2.84280649
103pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.83799460
104positive regulation of cell cycle arrest (GO:0071158)2.83116618
105regulation of chromosome segregation (GO:0051983)2.83010121
1067-methylguanosine mRNA capping (GO:0006370)2.82455113
107spliceosomal complex assembly (GO:0000245)2.82284926
108regulation of cellular amino acid metabolic process (GO:0006521)2.80425652
109* ribosomal small subunit assembly (GO:0000028)2.80015695
110iron-sulfur cluster assembly (GO:0016226)2.79527234
111metallo-sulfur cluster assembly (GO:0031163)2.79527234
112mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.79505777
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.79505777
114NADH dehydrogenase complex assembly (GO:0010257)2.79505777
115mitotic nuclear envelope disassembly (GO:0007077)2.79361103
116chromatin remodeling at centromere (GO:0031055)2.79154964
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78971328
118tRNA methylation (GO:0030488)2.78737251
119replication fork processing (GO:0031297)2.78349290
120pteridine-containing compound biosynthetic process (GO:0042559)2.76609791
121cell cycle G1/S phase transition (GO:0044843)2.76090106
122G1/S transition of mitotic cell cycle (GO:0000082)2.76090106
123deoxyribonucleotide biosynthetic process (GO:0009263)2.73250912
124DNA unwinding involved in DNA replication (GO:0006268)2.72937374
125nucleoside salvage (GO:0043174)2.72346244
1267-methylguanosine RNA capping (GO:0009452)2.70389147
127RNA capping (GO:0036260)2.70389147
128mitotic metaphase plate congression (GO:0007080)2.69220813
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68001839
130tetrahydrofolate metabolic process (GO:0046653)2.67871820
131pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.67740877
132GMP metabolic process (GO:0046037)2.66794425
133protein localization to kinetochore (GO:0034501)2.65924731
134protein complex biogenesis (GO:0070271)2.65824869
135ribosome assembly (GO:0042255)2.63934328
136ribonucleoprotein complex biogenesis (GO:0022613)2.63695728
137protoporphyrinogen IX metabolic process (GO:0046501)2.63685045
138somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62200239
139somatic hypermutation of immunoglobulin genes (GO:0016446)2.62200239
140IMP metabolic process (GO:0046040)2.61243252
141mitochondrial respiratory chain complex assembly (GO:0033108)2.58825447
1422-deoxyribonucleotide biosynthetic process (GO:0009265)2.57429794
143deoxyribose phosphate biosynthetic process (GO:0046385)2.57429794
144rRNA processing (GO:0006364)2.56256367
145positive regulation of ligase activity (GO:0051351)2.55808131
146folic acid-containing compound metabolic process (GO:0006760)2.55774183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.51282042
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.39749164
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84797043
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69980840
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.55419370
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43388857
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.25804425
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.17376465
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.09059430
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.95316702
11* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89456661
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81712092
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80915666
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73331169
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69604016
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51515045
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.50719065
18* VDR_23849224_ChIP-Seq_CD4+_Human2.46872381
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31173883
20FOXP3_21729870_ChIP-Seq_TREG_Human2.30649631
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26971538
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.25807867
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24809962
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24346876
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15579123
26* SRF_21415370_ChIP-Seq_HL-1_Mouse2.14881662
27DCP1A_22483619_ChIP-Seq_HELA_Human2.14300577
28XRN2_22483619_ChIP-Seq_HELA_Human2.11270534
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09458337
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.03184582
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02722094
32CIITA_25753668_ChIP-Seq_RAJI_Human2.02187440
33GABP_19822575_ChIP-Seq_HepG2_Human2.00992781
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99254546
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96727983
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94526972
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91152078
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89786572
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74087973
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72179546
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.67824149
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66505130
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65281102
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63385586
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63243863
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61306916
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60864902
48ELK1_19687146_ChIP-ChIP_HELA_Human1.59434131
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59253768
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57464134
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54569370
52GATA1_22025678_ChIP-Seq_K562_Human1.49062554
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47675196
54MYC_22102868_ChIP-Seq_BL_Human1.46811127
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46119428
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44748007
57TTF2_22483619_ChIP-Seq_HELA_Human1.42983333
58CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40310621
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39666966
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39353551
61* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33612447
62KDM5A_27292631_Chip-Seq_BREAST_Human1.32100569
63AR_21909140_ChIP-Seq_LNCAP_Human1.30456634
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28887981
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28198912
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28062082
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26516486
68BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23914017
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.23775942
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22335478
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17207378
72SPI1_23547873_ChIP-Seq_NB4_Human1.14421159
73ZNF263_19887448_ChIP-Seq_K562_Human1.14163559
74ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13564238
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12704572
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12619480
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10516586
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08228135
79TFEB_21752829_ChIP-Seq_HELA_Human1.06709774
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04957033
81CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04739105
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.03552908
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03338127
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01740025
85* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99680340
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98264374
87IRF8_21731497_ChIP-ChIP_J774_Mouse0.96531201
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96212347
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95930567
90* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95735837
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95629712
92* SOX17_20123909_ChIP-Seq_XEN_Mouse0.95533708
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95377985
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95311226
95MYC_18940864_ChIP-ChIP_HL60_Human0.94383799
96CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93603760
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93375502
98VDR_21846776_ChIP-Seq_THP-1_Human0.91480966
99STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89809744
100ELK1_22589737_ChIP-Seq_MCF10A_Human0.89754977
101* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89553526
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89123401
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88168885
104* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87881579
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86716909
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86578848
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86020021
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.83815869
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83288313
110* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83198532
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83155721
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83056252
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82147553
114* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81747870
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.81507322
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81271086
117FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81017580
118PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79177521
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.78571303
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78546358

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74385998
2MP0010094_abnormal_chromosome_stability4.15386387
3MP0003111_abnormal_nucleus_morphology3.46160345
4MP0003806_abnormal_nucleotide_metabolis3.29381433
5MP0008057_abnormal_DNA_replication3.26969553
6MP0004957_abnormal_blastocyst_morpholog3.20583577
7MP0000566_synostosis2.97054497
8MP0003077_abnormal_cell_cycle2.91486179
9MP0008058_abnormal_DNA_repair2.89199547
10MP0000372_irregular_coat_pigmentation2.75602081
11MP0008007_abnormal_cellular_replicative2.63092925
12MP0004147_increased_porphyrin_level2.62865662
13MP0002396_abnormal_hematopoietic_system2.61007361
14MP0003656_abnormal_erythrocyte_physiolo2.49781602
15MP0002132_abnormal_respiratory_system2.36563134
16MP0001835_abnormal_antigen_presentation2.10829467
17MP0006036_abnormal_mitochondrial_physio2.10639500
18MP0002139_abnormal_hepatobiliary_system1.88344960
19MP0003186_abnormal_redox_activity1.86954356
20MP0005671_abnormal_response_to1.84446446
21MP0001764_abnormal_homeostasis1.84169086
22MP0006035_abnormal_mitochondrial_morpho1.71278812
23MP0003763_abnormal_thymus_physiology1.71026369
24MP0003786_premature_aging1.68631671
25MP0001545_abnormal_hematopoietic_system1.64408318
26MP0005397_hematopoietic_system_phenotyp1.64408318
27MP0000490_abnormal_crypts_of1.63603677
28MP0002398_abnormal_bone_marrow1.61602711
29MP0010030_abnormal_orbit_morphology1.60109677
30MP0005360_urolithiasis1.58164717
31MP0009697_abnormal_copulation1.54949201
32MP0001529_abnormal_vocalization1.50607366
33MP0003718_maternal_effect1.49450616
34MP0000689_abnormal_spleen_morphology1.48736732
35MP0005408_hypopigmentation1.43049741
36MP0008932_abnormal_embryonic_tissue1.42876737
37MP0009333_abnormal_splenocyte_physiolog1.42446810
38MP0002722_abnormal_immune_system1.42097295
39MP0005670_abnormal_white_adipose1.41755064
40MP0001986_abnormal_taste_sensitivity1.41103763
41MP0002751_abnormal_autonomic_nervous1.39231402
42MP0003646_muscle_fatigue1.39135885
43MP0001853_heart_inflammation1.38262466
44MP0004233_abnormal_muscle_weight1.36808782
45MP0008789_abnormal_olfactory_epithelium1.31655621
46MP0002429_abnormal_blood_cell1.31164439
47MP0002420_abnormal_adaptive_immunity1.29387127
48MP0001800_abnormal_humoral_immune1.29030572
49MP0005365_abnormal_bile_salt1.27395840
50MP0001819_abnormal_immune_cell1.27259163
51MP0003436_decreased_susceptibility_to1.26283996
52MP0002019_abnormal_tumor_incidence1.24480694
53MP0002938_white_spotting1.24470007
54MP0000716_abnormal_immune_system1.24151489
55MP0006292_abnormal_olfactory_placode1.23618935
56MP0000313_abnormal_cell_death1.23217952
57MP0005075_abnormal_melanosome_morpholog1.22828433
58MP0001730_embryonic_growth_arrest1.21342444
59MP0008877_abnormal_DNA_methylation1.20830006
60MP0005266_abnormal_metabolism1.20486977
61MP0009785_altered_susceptibility_to1.20220615
62MP0001293_anophthalmia1.20186284
63MP0002452_abnormal_antigen_presenting1.19676827
64MP0001661_extended_life_span1.19492094
65MP0002085_abnormal_embryonic_tissue1.18842862
66MP0000685_abnormal_immune_system1.17324607
67MP0002723_abnormal_immune_serum1.17140851
68MP0000358_abnormal_cell_content/1.16478944
69MP0005025_abnormal_response_to1.15775332
70MP0000703_abnormal_thymus_morphology1.15458013
71MP0001346_abnormal_lacrimal_gland1.15191673
72MP0000350_abnormal_cell_proliferation1.14343274
73MP0002419_abnormal_innate_immunity1.13209986
74MP0002148_abnormal_hypersensitivity_rea1.13091211
75MP0004808_abnormal_hematopoietic_stem1.12728041
76MP0005330_cardiomyopathy1.10856817
77MP0000467_abnormal_esophagus_morphology1.08875719
78MP0003315_abnormal_perineum_morphology1.08802844
79MP0000751_myopathy1.07746514
80MP0003567_abnormal_fetal_cardiomyocyte1.03990833
81MP0003221_abnormal_cardiomyocyte_apopto1.03797696
82MP0005319_abnormal_enzyme/_coenzyme1.02608389
83MP0008469_abnormal_protein_level1.02229823
84MP0002736_abnormal_nociception_after1.01435566
85MP0006054_spinal_hemorrhage1.00922727
86MP0002080_prenatal_lethality1.00581677
87MP0005085_abnormal_gallbladder_physiolo0.99480498
88MP0005332_abnormal_amino_acid0.98712802
89MP0003941_abnormal_skin_development0.98461815
90MP0001790_abnormal_immune_system0.98293628
91MP0005387_immune_system_phenotype0.98293628
92MP0002102_abnormal_ear_morphology0.98098348
93MP0003937_abnormal_limbs/digits/tail_de0.97582750
94MP0005171_absent_coat_pigmentation0.97090536
95MP0001929_abnormal_gametogenesis0.96966929
96MP0005394_taste/olfaction_phenotype0.96599553
97MP0005499_abnormal_olfactory_system0.96599553
98MP0002254_reproductive_system_inflammat0.95892229
99MP0005000_abnormal_immune_tolerance0.95855840
100MP0002084_abnormal_developmental_patter0.94789875
101MP0005501_abnormal_skin_physiology0.94391607
102MP0003123_paternal_imprinting0.93204512
103MP0002163_abnormal_gland_morphology0.92677133
104MP0001697_abnormal_embryo_size0.92259583
105MP0002405_respiratory_system_inflammati0.91826759
106MP0002090_abnormal_vision0.90980742
107MP0002876_abnormal_thyroid_physiology0.88609867
108MP0001672_abnormal_embryogenesis/_devel0.88183833
109MP0005380_embryogenesis_phenotype0.88183833
110MP0000598_abnormal_liver_morphology0.88054886
111MP0001145_abnormal_male_reproductive0.87441132
112MP0000609_abnormal_liver_physiology0.86594473
113MP0001727_abnormal_embryo_implantation0.86533712
114MP0005636_abnormal_mineral_homeostasis0.85562613
115MP0005395_other_phenotype0.85340186
116MP0005464_abnormal_platelet_physiology0.85298011
117MP0003984_embryonic_growth_retardation0.83871164
118MP0001919_abnormal_reproductive_system0.82478381
119MP0004133_heterotaxia0.81952172
120MP0005376_homeostasis/metabolism_phenot0.81395071
121MP0008875_abnormal_xenobiotic_pharmacok0.81390391
122MP0002088_abnormal_embryonic_growth/wei0.80875120
123MP0000653_abnormal_sex_gland0.80570288
124MP0002210_abnormal_sex_determination0.78590678
125MP0005384_cellular_phenotype0.78245891
126MP0010352_gastrointestinal_tract_polyps0.77190778
127MP0002970_abnormal_white_adipose0.76083096
128MP0010329_abnormal_lipoprotein_level0.75563637
129MP0001845_abnormal_inflammatory_respons0.75543067
130MP0000749_muscle_degeneration0.74991023
131MP0009672_abnormal_birth_weight0.72998364
132MP0008260_abnormal_autophagy0.72721878
133MP0000465_gastrointestinal_hemorrhage0.72459610
134MP0009643_abnormal_urine_homeostasis0.71583782
135MP0003119_abnormal_digestive_system0.71515085
136MP0003724_increased_susceptibility_to0.70486376
137MP0002234_abnormal_pharynx_morphology0.70407197
138MP0002638_abnormal_pupillary_reflex0.70246738
139MP0002269_muscular_atrophy0.70050788
140MP0003136_yellow_coat_color0.68377087
141MP0004197_abnormal_fetal_growth/weight/0.65781628
142MP0000647_abnormal_sebaceous_gland0.63570659
143MP0002233_abnormal_nose_morphology0.63490992
144MP0009703_decreased_birth_body0.63253453
145MP0002086_abnormal_extraembryonic_tissu0.63094833
146MP0005389_reproductive_system_phenotype0.62096641
147MP0001286_abnormal_eye_development0.61790774
148MP0002111_abnormal_tail_morphology0.61266450
149MP0002161_abnormal_fertility/fecundity0.61024217
150MP0003115_abnormal_respiratory_system0.60519853
151MP0005220_abnormal_exocrine_pancreas0.58470824
152MP0001881_abnormal_mammary_gland0.58106611
153MP0003943_abnormal_hepatobiliary_system0.56730231
154MP0001119_abnormal_female_reproductive0.56661518
155MP0001915_intracranial_hemorrhage0.54807271

Predicted human phenotypes

RankGene SetZ-score
1Type I transferrin isoform profile (HP:0003642)3.93384480
2Hepatocellular necrosis (HP:0001404)3.87035139
3Hepatic necrosis (HP:0002605)3.82238470
4Abnormality of the heme biosynthetic pathway (HP:0010472)3.76928645
5Birth length less than 3rd percentile (HP:0003561)3.68515028
6Abnormal gallbladder physiology (HP:0012438)3.39100082
7Cholecystitis (HP:0001082)3.39100082
8Abnormal number of erythroid precursors (HP:0012131)3.35114401
9Abnormality of alanine metabolism (HP:0010916)3.31870142
10Hyperalaninemia (HP:0003348)3.31870142
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31870142
12Aplastic anemia (HP:0001915)3.31514356
13Increased serum lactate (HP:0002151)3.30529499
14Reduced antithrombin III activity (HP:0001976)3.26971578
15Progressive muscle weakness (HP:0003323)3.23143533
16Mitochondrial inheritance (HP:0001427)3.19290826
17Increased CSF lactate (HP:0002490)3.13530227
18Abnormality of cells of the erythroid lineage (HP:0012130)3.10503014
19Oral leukoplakia (HP:0002745)3.07855887
20Lactic acidosis (HP:0003128)3.06531674
21Abnormal mitochondria in muscle tissue (HP:0008316)2.94155270
22Hypoplastic pelvis (HP:0008839)2.92430950
23IgM deficiency (HP:0002850)2.88990693
24Acute encephalopathy (HP:0006846)2.87010986
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86978107
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86978107
27Acute necrotizing encephalopathy (HP:0006965)2.80007249
28Hyperglycinuria (HP:0003108)2.73914677
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73150000
30Abnormal protein glycosylation (HP:0012346)2.67538652
31Abnormal glycosylation (HP:0012345)2.67538652
32Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67538652
33Abnormal protein N-linked glycosylation (HP:0012347)2.67538652
34Lipid accumulation in hepatocytes (HP:0006561)2.65806667
35Ependymoma (HP:0002888)2.64204910
36Increased muscle lipid content (HP:0009058)2.63069945
37Reticulocytopenia (HP:0001896)2.59874535
38Abnormality of methionine metabolism (HP:0010901)2.58097736
39Multiple enchondromatosis (HP:0005701)2.57706242
40Vacuolated lymphocytes (HP:0001922)2.57695059
41Breast hypoplasia (HP:0003187)2.56496815
42Hyperglycinemia (HP:0002154)2.55844479
43Abnormality of pyrimidine metabolism (HP:0004353)2.51624576
44Increased intramyocellular lipid droplets (HP:0012240)2.51208573
45Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49256762
46Dicarboxylic aciduria (HP:0003215)2.49256762
47Chromsome breakage (HP:0040012)2.46434069
48Abnormality of serum amino acid levels (HP:0003112)2.44591483
49Postnatal microcephaly (HP:0005484)2.41815412
50Abnormality of serine family amino acid metabolism (HP:0010894)2.40502390
51Abnormality of glycine metabolism (HP:0010895)2.40502390
52Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39156395
53Increased hepatocellular lipid droplets (HP:0006565)2.37641503
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36199019
55Neoplasm of the adrenal gland (HP:0100631)2.33532096
56Pancytopenia (HP:0001876)2.31394449
57Exercise intolerance (HP:0003546)2.30201093
58Ragged-red muscle fibers (HP:0003200)2.29069808
59Neutropenia (HP:0001875)2.26281820
60Respiratory difficulties (HP:0002880)2.24419659
61Bone marrow hypocellularity (HP:0005528)2.24059780
62Abnormality of fatty-acid metabolism (HP:0004359)2.23573089
63Exertional dyspnea (HP:0002875)2.22415793
64Hyperammonemia (HP:0001987)2.20890598
65Horseshoe kidney (HP:0000085)2.19785711
66Microvesicular hepatic steatosis (HP:0001414)2.18694498
67Petechiae (HP:0000967)2.18554953
68Abnormal lung lobation (HP:0002101)2.15971178
69Microretrognathia (HP:0000308)2.15896557
70Meckel diverticulum (HP:0002245)2.15660819
71Lethargy (HP:0001254)2.14472356
723-Methylglutaconic aciduria (HP:0003535)2.14262423
73Abnormality of the labia minora (HP:0012880)2.14175930
74Hypokinesia (HP:0002375)2.13414515
75Abnormality of the umbilical cord (HP:0010881)2.12294172
76Hyperbilirubinemia (HP:0002904)2.12041052
77CNS demyelination (HP:0007305)2.11556074
78Abnormality of the ileum (HP:0001549)2.10619012
79Selective tooth agenesis (HP:0001592)2.10608383
80Optic nerve coloboma (HP:0000588)2.10355807
81Cerebral edema (HP:0002181)2.10163202
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09217853
83Abnormality of the preputium (HP:0100587)2.09125038
84Progressive macrocephaly (HP:0004481)2.08922843
85IgG deficiency (HP:0004315)2.08520156
86Nausea (HP:0002018)2.05065144
87Degeneration of anterior horn cells (HP:0002398)2.04436195
88Abnormality of the anterior horn cell (HP:0006802)2.04436195
89Abnormality of chromosome stability (HP:0003220)2.04420697
90Patellar aplasia (HP:0006443)2.04416831
91Myelodysplasia (HP:0002863)2.04365632
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04101768
93Autoamputation (HP:0001218)2.03689217
94Opisthotonus (HP:0002179)2.02527848
95Long foot (HP:0001833)2.02037350
96CNS hypomyelination (HP:0003429)2.02008092
97Abnormality of the fetal cardiovascular system (HP:0010948)1.99510293
98Abnormal umbilical cord blood vessels (HP:0011403)1.99510293
99Single umbilical artery (HP:0001195)1.99510293
100Cholelithiasis (HP:0001081)1.99426545
101Agnosia (HP:0010524)1.99025564
102Abnormal gallbladder morphology (HP:0012437)1.98950836
103Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98770755
104Duplicated collecting system (HP:0000081)1.98666319
105Colon cancer (HP:0003003)1.97376812
106Leukodystrophy (HP:0002415)1.94999481
107Respiratory failure (HP:0002878)1.94041709
108Rhabdomyolysis (HP:0003201)1.93143224
109Emotional lability (HP:0000712)1.91938219
110Secondary amenorrhea (HP:0000869)1.91348976
111Bile duct proliferation (HP:0001408)1.90717156
112Abnormal biliary tract physiology (HP:0012439)1.90717156
113Methylmalonic acidemia (HP:0002912)1.90477706
114Lymphoma (HP:0002665)1.90127521
115Dry hair (HP:0011359)1.88253033
116Abnormality of the astrocytes (HP:0100707)1.87155968
117Astrocytoma (HP:0009592)1.87155968
118Rough bone trabeculation (HP:0100670)1.86816045
119Hypoplasia of the thymus (HP:0000778)1.84744577
120Hypoproteinemia (HP:0003075)1.83881051
121Abnormality of T cell physiology (HP:0011840)1.82901859
122Severe muscular hypotonia (HP:0006829)1.81936794
123Methylmalonic aciduria (HP:0012120)1.79652648
124Abnormality of glycolysis (HP:0004366)1.79651392
125Increased serum pyruvate (HP:0003542)1.79651392
126Aplasia/Hypoplasia of the patella (HP:0006498)1.79517352
127Sparse eyelashes (HP:0000653)1.79110048
128Brushfield spots (HP:0001088)1.78868730
129Abnormalities of placenta or umbilical cord (HP:0001194)1.78742961
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.78174450
131Cerebral hypomyelination (HP:0006808)1.77554044
132Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77314234
133Bifid tongue (HP:0010297)1.75018765
134Renal Fanconi syndrome (HP:0001994)1.74442554
135Pallor (HP:0000980)1.74434804
136Generalized aminoaciduria (HP:0002909)1.73804696
137Ureteral duplication (HP:0000073)1.73312194
138Spastic paraparesis (HP:0002313)1.72868105
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.72827536
140Megaloblastic anemia (HP:0001889)1.72726947
141Tongue fasciculations (HP:0001308)1.72484259
142Cerebral palsy (HP:0100021)1.72290296
143Atrophy/Degeneration involving motor neurons (HP:0007373)1.69667460
144Testicular atrophy (HP:0000029)1.69459853
145Small intestinal stenosis (HP:0012848)1.68643151
146Duodenal stenosis (HP:0100867)1.68643151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44660579
2STK164.07241386
3VRK24.01908920
4PLK42.95327095
5WEE12.73657221
6EIF2AK12.72942935
7TESK22.41230830
8NEK12.40041403
9BRSK22.34979467
10TSSK62.27125077
11MAP4K12.08905514
12SRPK12.04529875
13FLT32.03213648
14TRIM282.01858905
15ACVR1B2.01335388
16CDC71.98233845
17VRK11.97268605
18NME21.93802670
19EIF2AK31.88411809
20BCKDK1.86318209
21BRSK11.84225942
22TAF11.81307930
23TXK1.80095493
24BRD41.64319464
25PIM21.60874731
26ZAK1.58211467
27TAOK11.46787464
28KDR1.41796981
29TLK11.41761098
30NEK21.39293820
31IRAK41.30315377
32NME11.29808363
33PLK11.22180162
34IRAK31.21091481
35MST41.19105399
36ATR1.19040741
37NUAK11.18781646
38CCNB11.18663301
39AURKB1.16011451
40LIMK11.15795038
41CSF1R1.15222333
42SMG11.14882182
43CSNK1G31.13030591
44KIT1.12396675
45TGFBR11.12116138
46ABL21.10456053
47TTK1.09066125
48LMTK21.08729249
49MAP3K31.07955513
50MKNK11.01736404
51EPHA31.00886504
52PIM10.98348378
53EIF2AK20.96917621
54STK40.96772388
55TESK10.96279381
56CDK80.94274298
57PDK30.94176058
58PDK40.94176058
59ZAP700.92193494
60CSNK1G10.92119010
61TAOK20.91986560
62AURKA0.91725019
63CSNK1A1L0.91382161
64SIK30.87406885
65CDK70.86828414
66ERBB40.86568424
67MAP4K20.85971853
68NLK0.84882046
69MAPK110.84049757
70CHEK20.83018778
71TYK20.82433680
72RPS6KA40.81764359
73PASK0.79608566
74MST1R0.79091874
75CSNK1G20.78498728
76JAK30.76636692
77BCR0.76304671
78DYRK20.75063071
79RPS6KB20.74433321
80BTK0.73514164
81PLK30.72061864
82DYRK30.71193111
83PBK0.70216841
84MKNK20.69703713
85MAP2K30.68560449
86STK100.68273062
87CDK40.67346222
88MYLK0.63989905
89TEC0.61350714
90TRPM70.61240812
91SYK0.60302289
92CSNK2A10.58076415
93EPHA20.57690899
94PAK40.55622395
95TBK10.55494266
96TNK20.55377473
97RPS6KA50.54478998
98CHEK10.54463244
99CSNK2A20.53335987
100MAPKAPK50.52917786
101LYN0.52835529
102MAP3K80.52700029
103BMPR1B0.50629867
104WNK30.49530014
105SCYL20.48860742
106ALK0.47065938
107AKT30.46842888
108DAPK10.46739265
109PRKD30.46349745
110BRAF0.46290174
111RPS6KB10.46081566
112PDK20.45898397
113PRKCI0.45524935
114MAP3K110.44768869
115MAP3K120.44081252
116CLK10.43398226
117ERBB30.42503481
118INSRR0.42080380
119* CDK20.40857040
120FGFR40.40357626
121MAPKAPK30.40278853
122MAP3K50.40025458
123MINK10.39355050
124ATM0.37584098
125CDK180.37360092
126IKBKB0.35839423
127AKT20.35305118
128YES10.35039183
129ITK0.34656945
130PLK20.34551108
131CDK90.34338909
132CDK140.34022724
133CDK10.33652006
134GRK60.32949804
135RPS6KA60.31838782
136CDK150.31186741
137EEF2K0.30213034
138PAK10.30160597
139CDK11A0.28552704
140DYRK1A0.28303920
141CSNK1E0.27600151
142CSNK1A10.26957173
143NTRK10.25430536
144GRK50.23002585

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.07528542
2Mismatch repair_Homo sapiens_hsa034303.45300283
3Proteasome_Homo sapiens_hsa030503.41531737
4Base excision repair_Homo sapiens_hsa034103.01201592
5RNA polymerase_Homo sapiens_hsa030202.86889469
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77088662
7Pyrimidine metabolism_Homo sapiens_hsa002402.51110554
8One carbon pool by folate_Homo sapiens_hsa006702.49639996
9Spliceosome_Homo sapiens_hsa030402.39202455
10Homologous recombination_Homo sapiens_hsa034402.38045110
11Nucleotide excision repair_Homo sapiens_hsa034202.34506524
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.33234128
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29790886
14Ribosome_Homo sapiens_hsa030102.25033792
15Non-homologous end-joining_Homo sapiens_hsa034502.05077707
16RNA transport_Homo sapiens_hsa030131.94841448
17Protein export_Homo sapiens_hsa030601.84107550
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71071921
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.67155490
20Fanconi anemia pathway_Homo sapiens_hsa034601.59442028
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56871343
22Cell cycle_Homo sapiens_hsa041101.55117430
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54749016
24RNA degradation_Homo sapiens_hsa030181.54699566
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.52649671
26Carbon metabolism_Homo sapiens_hsa012001.47253411
27Basal transcription factors_Homo sapiens_hsa030221.46983464
28Biosynthesis of amino acids_Homo sapiens_hsa012301.44197563
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41488743
30Pentose phosphate pathway_Homo sapiens_hsa000301.39001441
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.38375059
32Purine metabolism_Homo sapiens_hsa002301.37456100
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29282834
34Folate biosynthesis_Homo sapiens_hsa007901.23586566
35Propanoate metabolism_Homo sapiens_hsa006401.15161423
36Primary immunodeficiency_Homo sapiens_hsa053401.15091730
37Pyruvate metabolism_Homo sapiens_hsa006201.12715280
38Steroid biosynthesis_Homo sapiens_hsa001001.09624106
39Parkinsons disease_Homo sapiens_hsa050121.08949911
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07464131
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06506003
42Galactose metabolism_Homo sapiens_hsa000521.04782916
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03297989
44Selenocompound metabolism_Homo sapiens_hsa004501.02217739
45Fatty acid degradation_Homo sapiens_hsa000711.01445520
46Vitamin B6 metabolism_Homo sapiens_hsa007500.99400217
47Oxidative phosphorylation_Homo sapiens_hsa001900.96587589
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96201418
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93795310
50Systemic lupus erythematosus_Homo sapiens_hsa053220.93745457
51Fructose and mannose metabolism_Homo sapiens_hsa000510.92146212
52mRNA surveillance pathway_Homo sapiens_hsa030150.91654182
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89309209
54Sulfur relay system_Homo sapiens_hsa041220.87407554
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84126702
56p53 signaling pathway_Homo sapiens_hsa041150.82649241
57N-Glycan biosynthesis_Homo sapiens_hsa005100.82335262
58Regulation of autophagy_Homo sapiens_hsa041400.82223258
59Oocyte meiosis_Homo sapiens_hsa041140.81247598
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80976966
61Butanoate metabolism_Homo sapiens_hsa006500.80871406
62Peroxisome_Homo sapiens_hsa041460.80266984
63Herpes simplex infection_Homo sapiens_hsa051680.79520220
64Epstein-Barr virus infection_Homo sapiens_hsa051690.79048108
65Huntingtons disease_Homo sapiens_hsa050160.74696332
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.74386698
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73698679
68Metabolic pathways_Homo sapiens_hsa011000.71283500
69Antigen processing and presentation_Homo sapiens_hsa046120.68909857
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.67030608
71Other glycan degradation_Homo sapiens_hsa005110.63931617
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.62810631
73Legionellosis_Homo sapiens_hsa051340.61698494
74Caffeine metabolism_Homo sapiens_hsa002320.61288053
75Fatty acid metabolism_Homo sapiens_hsa012120.60667079
76Tyrosine metabolism_Homo sapiens_hsa003500.56340590
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55291649
78Tryptophan metabolism_Homo sapiens_hsa003800.55222353
79Allograft rejection_Homo sapiens_hsa053300.53561307
80Arginine biosynthesis_Homo sapiens_hsa002200.49747341
81Vibrio cholerae infection_Homo sapiens_hsa051100.46210397
82Arginine and proline metabolism_Homo sapiens_hsa003300.46101545
83Alzheimers disease_Homo sapiens_hsa050100.44034003
84Glutathione metabolism_Homo sapiens_hsa004800.43943812
85Fatty acid elongation_Homo sapiens_hsa000620.40221661
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38807537
87Measles_Homo sapiens_hsa051620.38584729
88Vitamin digestion and absorption_Homo sapiens_hsa049770.38547520
89beta-Alanine metabolism_Homo sapiens_hsa004100.37239424
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37124271
91Sulfur metabolism_Homo sapiens_hsa009200.32898693
92Collecting duct acid secretion_Homo sapiens_hsa049660.32592644
93Glycerolipid metabolism_Homo sapiens_hsa005610.32445649
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32292116
95Viral carcinogenesis_Homo sapiens_hsa052030.31703992
96Arachidonic acid metabolism_Homo sapiens_hsa005900.30928128
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30891020
98ABC transporters_Homo sapiens_hsa020100.30424774
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26898298
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26698040
101Phenylalanine metabolism_Homo sapiens_hsa003600.26337172
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.25588838
103Cardiac muscle contraction_Homo sapiens_hsa042600.24865517
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23886055
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23126841
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22877116
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22768741
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22477123
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22208374
110Hematopoietic cell lineage_Homo sapiens_hsa046400.21969405
111Retinol metabolism_Homo sapiens_hsa008300.18343886
112Starch and sucrose metabolism_Homo sapiens_hsa005000.16118538
113Lysine degradation_Homo sapiens_hsa003100.15669344
114Fat digestion and absorption_Homo sapiens_hsa049750.13668124
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10821697
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09960038
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.09497147
118Chemical carcinogenesis_Homo sapiens_hsa052040.07154940

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