ERAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88136467
2* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88136467
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.82581781
4negative regulation of cell killing (GO:0031342)4.82581781
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.72767978
6L-phenylalanine catabolic process (GO:0006559)4.72767978
7L-phenylalanine metabolic process (GO:0006558)4.53597096
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.53597096
9aromatic amino acid family catabolic process (GO:0009074)4.38276768
10alpha-linolenic acid metabolic process (GO:0036109)4.32891690
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.27655499
12* antigen processing and presentation of endogenous antigen (GO:0019883)4.25512370
13tryptophan catabolic process (GO:0006569)4.11134361
14indole-containing compound catabolic process (GO:0042436)4.11134361
15indolalkylamine catabolic process (GO:0046218)4.11134361
16regulation of B cell receptor signaling pathway (GO:0050855)4.06881129
17urea cycle (GO:0000050)4.06297112
18urea metabolic process (GO:0019627)4.06297112
19kynurenine metabolic process (GO:0070189)4.04193531
20complement activation, alternative pathway (GO:0006957)4.03475420
21tryptophan metabolic process (GO:0006568)3.93526531
22bile acid biosynthetic process (GO:0006699)3.91590208
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.90622955
24negative thymic T cell selection (GO:0045060)3.89304956
25protein carboxylation (GO:0018214)3.86677599
26peptidyl-glutamic acid carboxylation (GO:0017187)3.86677599
27negative T cell selection (GO:0043383)3.86362291
28regulation of protein activation cascade (GO:2000257)3.77550497
29high-density lipoprotein particle remodeling (GO:0034375)3.70861855
30cellular extravasation (GO:0045123)3.68738377
31negative regulation of fibrinolysis (GO:0051918)3.68713252
32detection of other organism (GO:0098543)3.68132127
33nitrogen cycle metabolic process (GO:0071941)3.64942970
34glyoxylate metabolic process (GO:0046487)3.61937199
35positive thymic T cell selection (GO:0045059)3.61084352
36sulfur amino acid catabolic process (GO:0000098)3.60478688
37positive regulation of gamma-delta T cell activation (GO:0046645)3.60379408
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59935787
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.59935787
40modulation by symbiont of host immune response (GO:0052553)3.59935787
41positive regulation by symbiont of host defense response (GO:0052509)3.59935787
42modulation by symbiont of host defense response (GO:0052031)3.59935787
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59935787
44regulation of triglyceride catabolic process (GO:0010896)3.59108565
45valine metabolic process (GO:0006573)3.58095626
46regulation of complement activation (GO:0030449)3.57544681
47detection of bacterium (GO:0016045)3.56679668
48B cell receptor signaling pathway (GO:0050853)3.50005449
49cysteine metabolic process (GO:0006534)3.46662509
50regulation of fibrinolysis (GO:0051917)3.42469087
51phospholipid efflux (GO:0033700)3.41372301
52bile acid metabolic process (GO:0008206)3.37394733
53homocysteine metabolic process (GO:0050667)3.37010803
54reverse cholesterol transport (GO:0043691)3.35228204
55plasma lipoprotein particle remodeling (GO:0034369)3.34064544
56protein-lipid complex remodeling (GO:0034368)3.34064544
57macromolecular complex remodeling (GO:0034367)3.34064544
58type I interferon signaling pathway (GO:0060337)3.33452782
59cellular response to type I interferon (GO:0071357)3.33452782
60response to type I interferon (GO:0034340)3.33427677
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.32764631
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31142088
63negative regulation of erythrocyte differentiation (GO:0045647)3.30360867
64negative regulation of sterol transport (GO:0032372)3.28980574
65negative regulation of cholesterol transport (GO:0032375)3.28980574
66immunoglobulin mediated immune response (GO:0016064)3.27952823
67lysine catabolic process (GO:0006554)3.25622698
68lysine metabolic process (GO:0006553)3.25622698
69T cell migration (GO:0072678)3.25052834
70amino-acid betaine metabolic process (GO:0006577)3.23298417
71positive regulation of B cell differentiation (GO:0045579)3.22791108
72plasma lipoprotein particle assembly (GO:0034377)3.22782519
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21186014
74macrophage activation involved in immune response (GO:0002281)3.19184410
75plasma lipoprotein particle clearance (GO:0034381)3.18346382
76regulation of cholesterol esterification (GO:0010872)3.18177791
77bile acid and bile salt transport (GO:0015721)3.17382648
78positive T cell selection (GO:0043368)3.17050659
79regulation of gamma-delta T cell differentiation (GO:0045586)3.13739352
80interferon-gamma-mediated signaling pathway (GO:0060333)3.12589924
81response to interleukin-15 (GO:0070672)3.10923339
82T cell selection (GO:0045058)3.09339266
83regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08878540
84aromatic amino acid family metabolic process (GO:0009072)3.08031458
85thymic T cell selection (GO:0045061)3.07470275
86phospholipid homeostasis (GO:0055091)3.06959261
87detection of external biotic stimulus (GO:0098581)3.05262601
88antigen processing and presentation via MHC class Ib (GO:0002475)3.03718350
89low-density lipoprotein particle remodeling (GO:0034374)3.03464146
90acylglycerol homeostasis (GO:0055090)3.02957526
91triglyceride homeostasis (GO:0070328)3.02957526
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.01101220
93killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.00420585
94disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.00420585
95serine family amino acid catabolic process (GO:0009071)2.98999510
96regulation of interferon-beta biosynthetic process (GO:0045357)2.98748988
97response to muramyl dipeptide (GO:0032495)2.97960030
98ethanol oxidation (GO:0006069)2.96910199
99tyrosine metabolic process (GO:0006570)2.96444444
100negative regulation of interleukin-12 production (GO:0032695)2.95542625
101glycine metabolic process (GO:0006544)2.94659567
102cholesterol efflux (GO:0033344)2.94304032
103cellular glucuronidation (GO:0052695)2.94035144
104germinal center formation (GO:0002467)2.93727281
105protein-lipid complex assembly (GO:0065005)2.93401259
106response to peptidoglycan (GO:0032494)2.92919990
107regulation of B cell differentiation (GO:0045577)2.91460337
108complement activation, classical pathway (GO:0006958)2.90191203
109regulation of T cell tolerance induction (GO:0002664)2.89493090
110complement activation (GO:0006956)2.88484894
111regulation of humoral immune response (GO:0002920)2.88475462
112negative regulation of T cell mediated immunity (GO:0002710)2.86771812
113plasma lipoprotein particle organization (GO:0071827)2.85513670
114neutrophil activation involved in immune response (GO:0002283)2.85132519
115regulation of tolerance induction (GO:0002643)2.85068649
116leukocyte aggregation (GO:0070486)2.85061173
117regulation of gamma-delta T cell activation (GO:0046643)2.84693385
118indolalkylamine metabolic process (GO:0006586)2.83786453
119benzene-containing compound metabolic process (GO:0042537)2.83235196
120alpha-amino acid catabolic process (GO:1901606)2.83091886
121regulation of cholesterol homeostasis (GO:2000188)2.80592808
122protein activation cascade (GO:0072376)2.80008910
123negative regulation of leukocyte mediated immunity (GO:0002704)2.78961612
124imidazole-containing compound metabolic process (GO:0052803)2.78884609
125cytolysis (GO:0019835)2.78059970
1262-oxoglutarate metabolic process (GO:0006103)2.77362728
127acute-phase response (GO:0006953)2.74869377
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.73629914
129cholesterol homeostasis (GO:0042632)2.72205590
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72027228
131fibrinolysis (GO:0042730)2.71415523
132amine catabolic process (GO:0009310)2.70966002
133cellular biogenic amine catabolic process (GO:0042402)2.70966002
134protein-lipid complex subunit organization (GO:0071825)2.70858026
135regulation of antigen processing and presentation (GO:0002577)2.70851042
136positive regulation of triglyceride lipase activity (GO:0061365)2.69831036
137positive regulation of lipoprotein lipase activity (GO:0051006)2.69831036
138NIK/NF-kappaB signaling (GO:0038061)2.69219492
139positive regulation of granulocyte differentiation (GO:0030854)2.68979700
140sterol homeostasis (GO:0055092)2.68549225
141positive regulation of lipid catabolic process (GO:0050996)2.67737213
142detection of molecule of bacterial origin (GO:0032490)2.66463999
143lipoprotein metabolic process (GO:0042157)2.66142670
144killing of cells of other organism (GO:0031640)2.65928865
145disruption of cells of other organism (GO:0044364)2.65928865
146detection of biotic stimulus (GO:0009595)2.65919094
147mannose metabolic process (GO:0006013)2.65582365
148response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.65354493
149response to host (GO:0075136)2.65354493
150response to host defenses (GO:0052200)2.65354493
151cellular response to interleukin-15 (GO:0071350)2.65350000
152positive regulation of tolerance induction (GO:0002645)2.64759472
153response to nitrosative stress (GO:0051409)2.63791391
154cellular modified amino acid catabolic process (GO:0042219)2.63524754
155regulation of alpha-beta T cell proliferation (GO:0046640)2.62945020
156serine family amino acid metabolic process (GO:0009069)2.62015393
157regulation of necroptotic process (GO:0060544)2.61553895
158serine family amino acid biosynthetic process (GO:0009070)2.60952700
159dicarboxylic acid biosynthetic process (GO:0043650)2.60178134
160blood coagulation, intrinsic pathway (GO:0007597)2.59690589
161response to host immune response (GO:0052572)2.58886578
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58886578
163positive regulation of antigen processing and presentation (GO:0002579)2.57725626
164JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56110123
165regulation of T cell mediated cytotoxicity (GO:0001914)2.55642160
166T cell costimulation (GO:0031295)2.54879579
167B cell mediated immunity (GO:0019724)2.52814003
168lymphocyte costimulation (GO:0031294)2.50444217
169regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50429447
170regulation of natural killer cell mediated immunity (GO:0002715)2.50429447
171regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50407499
172positive regulation of interferon-alpha production (GO:0032727)2.50137079
173myeloid dendritic cell activation (GO:0001773)2.48223884
174pinocytosis (GO:0006907)2.48217309
175myeloid dendritic cell differentiation (GO:0043011)2.46123181
176regulation of mast cell degranulation (GO:0043304)2.45921100
177antigen receptor-mediated signaling pathway (GO:0050851)2.43775133
178embryonic process involved in female pregnancy (GO:0060136)2.43146247
179regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42519796
180positive regulation of T cell mediated cytotoxicity (GO:0001916)2.42200274
181myeloid cell activation involved in immune response (GO:0002275)2.41774262
182negative regulation of innate immune response (GO:0045824)2.40763367
183tolerance induction (GO:0002507)2.40244617
184regulation of interleukin-2 biosynthetic process (GO:0045076)2.39504610
185positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.37283669
186cellular response to interferon-gamma (GO:0071346)2.37049203
187positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.36789132
188regulation of regulatory T cell differentiation (GO:0045589)2.36777682
189regulation of granulocyte differentiation (GO:0030852)2.36707366
190regulation of leukocyte degranulation (GO:0043300)2.36244784
191peptide catabolic process (GO:0043171)2.35826115
192T-helper 1 type immune response (GO:0042088)2.35813091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.54724205
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.68004592
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.38229783
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.33423694
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.05916154
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.68167097
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.35248692
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.34166861
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.09499787
10* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04852228
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98253930
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82508055
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.73324872
14GATA1_22025678_ChIP-Seq_K562_Human2.60401067
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56355222
16E2F7_22180533_ChIP-Seq_HELA_Human2.48392393
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.43519387
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26568250
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.24038143
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19723121
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10484743
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10371113
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.09325057
24SCL_19346495_ChIP-Seq_HPC-7_Human2.04030194
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03539505
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02429039
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01432416
28* IRF8_27001747_Chip-Seq_BMDM_Mouse2.01098024
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98189844
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.94638327
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84217727
32MYC_22102868_ChIP-Seq_BL_Human1.83862842
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83081119
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.77986925
35MYB_26560356_Chip-Seq_TH2_Human1.76894553
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.76228850
37* RUNX_20019798_ChIP-Seq_JUKART_Human1.74537141
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72465588
39CLOCK_20551151_ChIP-Seq_293T_Human1.69383710
40VDR_24787735_ChIP-Seq_THP-1_Human1.69053891
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68262062
42* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.67269128
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66618897
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.64583079
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64286346
46MAF_26560356_Chip-Seq_TH1_Human1.63818270
47MYB_26560356_Chip-Seq_TH1_Human1.62704933
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54331154
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51984155
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46923844
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45164093
52VDR_21846776_ChIP-Seq_THP-1_Human1.43076135
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36508812
54UTX_26944678_Chip-Seq_JUKART_Human1.34431708
55SPI1_23547873_ChIP-Seq_NB4_Human1.33927014
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32361208
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29857312
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25515700
59TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.25355948
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.25192367
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23176824
62KDM2B_26808549_Chip-Seq_DND41_Human1.22856582
63VDR_24763502_ChIP-Seq_THP-1_Human1.22478285
64* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22185286
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20696948
66ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19912895
67TCF7_22412390_ChIP-Seq_EML_Mouse1.16791038
68GATA3_27048872_Chip-Seq_THYMUS_Human1.15111801
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12349730
70PU_27001747_Chip-Seq_BMDM_Mouse1.09640257
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07093624
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06593613
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05773902
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.05370541
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04590993
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03677329
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01856585
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01063785
79LXR_22292898_ChIP-Seq_THP-1_Human0.99394517
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98104031
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97493711
82* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96402917
83MAF_26560356_Chip-Seq_TH2_Human0.95490710
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94899926
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94824917
86GATA3_26560356_Chip-Seq_TH2_Human0.94252514
87* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93718310
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93659410
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93424142
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92906471
91* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92773418
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91130414
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90959785
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90846290
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90515937
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90495194
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.90286790
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89958881
99ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89926755
100FOXA2_19822575_ChIP-Seq_HepG2_Human0.88650418
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87488942
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86038043
103* KDM2B_26808549_Chip-Seq_JURKAT_Human0.85534261
104GATA4_25053715_ChIP-Seq_YYC3_Human0.85107700
105GATA1_19941827_ChIP-Seq_MEL_Mouse0.85027359
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84444802
107SPI1_23127762_ChIP-Seq_K562_Human0.83920025
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83231034
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82829618
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80232846
111GATA2_19941826_ChIP-Seq_K562_Human0.78382884
112HNF4A_19822575_ChIP-Seq_HepG2_Human0.78076487
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77701177
114* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.76185564
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.76148756
116GATA1_19941826_ChIP-Seq_K562_Human0.75961558
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.75851640
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.75626786
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75443679
120GATA6_25053715_ChIP-Seq_YYC3_Human0.75329875
121TP63_17297297_ChIP-ChIP_HaCaT_Human0.73606947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75521469
2MP0005360_urolithiasis4.64576231
3MP0005365_abnormal_bile_salt3.80953191
4MP0005085_abnormal_gallbladder_physiolo3.76367287
5MP0008875_abnormal_xenobiotic_pharmacok2.99802194
6MP0003252_abnormal_bile_duct2.57779662
7MP0003300_gastrointestinal_ulcer2.47234445
8MP0009840_abnormal_foam_cell2.43955001
9MP0010329_abnormal_lipoprotein_level2.37145755
10* MP0001835_abnormal_antigen_presentation2.35534880
11MP0003191_abnormal_cellular_cholesterol2.15724017
12MP0003806_abnormal_nucleotide_metabolis2.13963671
13MP0002166_altered_tumor_susceptibility2.04659557
14MP0002138_abnormal_hepatobiliary_system2.02258827
15MP0003436_decreased_susceptibility_to1.97435454
16MP0003724_increased_susceptibility_to1.96052587
17MP0001666_abnormal_nutrient_absorption1.90878854
18MP0000685_abnormal_immune_system1.87792230
19MP0000609_abnormal_liver_physiology1.85995480
20MP0005671_abnormal_response_to1.81846855
21MP0009785_altered_susceptibility_to1.80431055
22MP0003763_abnormal_thymus_physiology1.77521028
23MP0005083_abnormal_biliary_tract1.76429281
24MP0001800_abnormal_humoral_immune1.68491874
25MP0003183_abnormal_peptide_metabolism1.67705206
26MP0005464_abnormal_platelet_physiology1.67270230
27MP0001790_abnormal_immune_system1.62196799
28MP0005387_immune_system_phenotype1.62196799
29MP0002396_abnormal_hematopoietic_system1.60642096
30MP0005451_abnormal_body_composition1.59461170
31* MP0005025_abnormal_response_to1.58637297
32MP0005332_abnormal_amino_acid1.53266220
33MP0002419_abnormal_innate_immunity1.50941861
34MP0005000_abnormal_immune_tolerance1.48865614
35MP0005319_abnormal_enzyme/_coenzyme1.48482255
36MP0002998_abnormal_bone_remodeling1.46444189
37MP0003828_pulmonary_edema1.44830153
38MP0002452_abnormal_antigen_presenting1.42845236
39MP0003195_calcinosis1.42723694
40MP0008469_abnormal_protein_level1.42005299
41MP0003303_peritoneal_inflammation1.41757314
42* MP0002723_abnormal_immune_serum1.41518889
43MP0002254_reproductive_system_inflammat1.41420533
44MP0002006_tumorigenesis1.41198720
45MP0001853_heart_inflammation1.40925085
46MP0010155_abnormal_intestine_physiology1.37593643
47MP0002118_abnormal_lipid_homeostasis1.34381163
48MP0001845_abnormal_inflammatory_respons1.34139920
49MP0001873_stomach_inflammation1.32941847
50* MP0002420_abnormal_adaptive_immunity1.29609429
51MP0009643_abnormal_urine_homeostasis1.28329388
52* MP0001819_abnormal_immune_cell1.28057359
53MP0004947_skin_inflammation1.27469436
54MP0003091_abnormal_cell_migration1.27427456
55MP0006082_CNS_inflammation1.26899920
56MP0001851_eye_inflammation1.23823846
57MP0009764_decreased_sensitivity_to1.23173193
58MP0005310_abnormal_salivary_gland1.21056203
59MP0002009_preneoplasia1.20244118
60MP0002405_respiratory_system_inflammati1.19902574
61MP0001764_abnormal_homeostasis1.19882297
62MP0003186_abnormal_redox_activity1.18973632
63MP0000598_abnormal_liver_morphology1.17202556
64MP0003868_abnormal_feces_composition1.16908756
65* MP0002398_abnormal_bone_marrow1.15539669
66MP0008260_abnormal_autophagy1.15118944
67MP0002148_abnormal_hypersensitivity_rea1.14637195
68MP0009763_increased_sensitivity_to1.14390584
69MP0005058_abnormal_lysosome_morphology1.13478781
70MP0005584_abnormal_enzyme/coenzyme_acti1.13272498
71MP0002933_joint_inflammation1.12927699
72* MP0000689_abnormal_spleen_morphology1.11798516
73* MP0000716_abnormal_immune_system1.11514180
74MP0006054_spinal_hemorrhage1.08518067
75MP0003045_fibrosis1.07720122
76MP0003566_abnormal_cell_adhesion1.06632717
77MP0005164_abnormal_response_to1.06503006
78MP0005397_hematopoietic_system_phenotyp1.06093173
79MP0001545_abnormal_hematopoietic_system1.06093173
80MP0004019_abnormal_vitamin_homeostasis1.05555595
81MP0004883_abnormal_blood_vessel1.04032224
82MP0003448_altered_tumor_morphology1.01936076
83* MP0002722_abnormal_immune_system1.01759653
84MP0008438_abnormal_cutaneous_collagen1.01483758
85MP0000465_gastrointestinal_hemorrhage1.01390518
86MP0003656_abnormal_erythrocyte_physiolo0.99370468
87MP0008004_abnormal_stomach_pH0.98777830
88MP0001533_abnormal_skeleton_physiology0.97910478
89MP0005670_abnormal_white_adipose0.97709098
90MP0003075_altered_response_to0.97637423
91MP0000604_amyloidosis0.96785476
92* MP0002429_abnormal_blood_cell0.96395784
93MP0004264_abnormal_extraembryonic_tissu0.95776529
94MP0010368_abnormal_lymphatic_system0.90189744
95MP0010234_abnormal_vibrissa_follicle0.89560975
96MP0009333_abnormal_splenocyte_physiolog0.89197284
97MP0004381_abnormal_hair_follicle0.87664446
98MP0004808_abnormal_hematopoietic_stem0.87575354
99MP0010352_gastrointestinal_tract_polyps0.86931813
100MP0005220_abnormal_exocrine_pancreas0.86632478
101MP0003866_abnormal_defecation0.86026223
102MP0009697_abnormal_copulation0.85623119
103MP0009115_abnormal_fat_cell0.85389436
104MP0000343_altered_response_to0.85222294
105MP0002877_abnormal_melanocyte_morpholog0.82959857
106MP0002136_abnormal_kidney_physiology0.82553232
107MP0005408_hypopigmentation0.82470196
108MP0010307_abnormal_tumor_latency0.80461352
109MP0003690_abnormal_glial_cell0.79878254
110MP0005666_abnormal_adipose_tissue0.79392047
111MP0002132_abnormal_respiratory_system0.79317343
112MP0003172_abnormal_lysosome_physiology0.79131780
113MP0003279_aneurysm0.79093624
114MP0003453_abnormal_keratinocyte_physiol0.78753286
115MP0001958_emphysema0.78203335
116MP0005023_abnormal_wound_healing0.77228685
117MP0001663_abnormal_digestive_system0.76961566
118MP0005390_skeleton_phenotype0.76484400
119MP0009278_abnormal_bone_marrow0.76227663
120MP0009642_abnormal_blood_homeostasis0.75951387
121MP0003705_abnormal_hypodermis_morpholog0.75906253
122MP0009765_abnormal_xenobiotic_induced0.75642274
123MP0005647_abnormal_sex_gland0.72036229
124* MP0000703_abnormal_thymus_morphology0.71728965
125MP0000858_altered_metastatic_potential0.71534852
126MP0005166_decreased_susceptibility_to0.71111004
127MP0005636_abnormal_mineral_homeostasis0.70578364
128MP0000249_abnormal_blood_vessel0.70524824
129MP0004782_abnormal_surfactant_physiolog0.69968740

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.83042472
2Intrahepatic cholestasis (HP:0001406)4.72451875
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.65481198
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.46463922
5Xanthomatosis (HP:0000991)4.26117863
6Prolonged partial thromboplastin time (HP:0003645)4.25533210
7Hypobetalipoproteinemia (HP:0003563)4.23667591
8Complement deficiency (HP:0004431)3.99752464
9Joint hemorrhage (HP:0005261)3.90454047
10Abnormality of the common coagulation pathway (HP:0010990)3.73077454
11Hyperlipoproteinemia (HP:0010980)3.57589478
12Abnormality of macrophages (HP:0004311)3.55314863
13Orchitis (HP:0100796)3.32168694
14Hypoglycemic coma (HP:0001325)3.29687725
15Hypolipoproteinemia (HP:0010981)3.13243317
16Meningitis (HP:0001287)3.12763518
17Myocardial infarction (HP:0001658)3.08921898
18Abnormality of the intrinsic pathway (HP:0010989)3.05666902
19Abnormality of complement system (HP:0005339)3.05034628
20Hyperammonemia (HP:0001987)3.03311274
21Retrobulbar optic neuritis (HP:0100654)3.02798138
22Optic neuritis (HP:0100653)3.02798138
23Fat malabsorption (HP:0002630)3.02456818
24Recurrent gram-negative bacterial infections (HP:0005420)3.00950734
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.00130812
26Gingival bleeding (HP:0000225)2.93071548
27Recurrent cutaneous fungal infections (HP:0011370)2.91994605
28Chronic mucocutaneous candidiasis (HP:0002728)2.91994605
29Gingivitis (HP:0000230)2.91639520
30Mediastinal lymphadenopathy (HP:0100721)2.91541083
31Cellulitis (HP:0100658)2.91238107
32Epidermoid cyst (HP:0200040)2.90997252
33Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90768658
34Ketosis (HP:0001946)2.84870708
35Agammaglobulinemia (HP:0004432)2.83331575
36Increased IgE level (HP:0003212)2.81870732
37T lymphocytopenia (HP:0005403)2.80809062
38Abnormality of sulfur amino acid metabolism (HP:0004339)2.79695515
39Systemic lupus erythematosus (HP:0002725)2.75525063
40Abnormality of T cell number (HP:0011839)2.74240889
41Conjugated hyperbilirubinemia (HP:0002908)2.72595996
42Chronic otitis media (HP:0000389)2.72551079
43Autoimmune hemolytic anemia (HP:0001890)2.69891521
44Spontaneous hematomas (HP:0007420)2.66859150
45Eczematoid dermatitis (HP:0000976)2.65890478
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63964042
47Hypercholesterolemia (HP:0003124)2.63793385
48Pulmonary infiltrates (HP:0002113)2.62646697
49Hypoalphalipoproteinemia (HP:0003233)2.62125654
50Thrombocytosis (HP:0001894)2.59762482
51Abnormality of methionine metabolism (HP:0010901)2.58244242
52Abnormality of fatty-acid metabolism (HP:0004359)2.56731343
53Recurrent viral infections (HP:0004429)2.55447004
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53665217
55Elevated erythrocyte sedimentation rate (HP:0003565)2.51108841
56Stomatitis (HP:0010280)2.50600876
57Epistaxis (HP:0000421)2.50097377
58Encephalitis (HP:0002383)2.47063636
59Recurrent bronchitis (HP:0002837)2.46802107
60Esophageal varix (HP:0002040)2.46684175
61Abnormality of pyrimidine metabolism (HP:0004353)2.41529837
62Malnutrition (HP:0004395)2.41466709
63Thrombophlebitis (HP:0004418)2.41395899
64Osteomyelitis (HP:0002754)2.40893350
65Autoimmune thrombocytopenia (HP:0001973)2.40153843
66Keratoconjunctivitis sicca (HP:0001097)2.39842334
67Hyperbilirubinemia (HP:0002904)2.39746427
68Chronic obstructive pulmonary disease (HP:0006510)2.38446139
69Obstructive lung disease (HP:0006536)2.38446139
70Hyperglycinuria (HP:0003108)2.38064894
71Abnormality of T cells (HP:0002843)2.36753390
72Abnormality of glycolipid metabolism (HP:0010969)2.35495231
73Abnormality of liposaccharide metabolism (HP:0010968)2.35495231
74Abnormality of glycosphingolipid metabolism (HP:0004343)2.35495231
75Abnormal platelet volume (HP:0011876)2.34714242
76Panhypogammaglobulinemia (HP:0003139)2.33687533
77Gastrointestinal stroma tumor (HP:0100723)2.32266497
78Hemoptysis (HP:0002105)2.31936114
79Pulmonary embolism (HP:0002204)2.30810239
80Chest pain (HP:0100749)2.28075392
81Hepatocellular carcinoma (HP:0001402)2.26664516
82Steatorrhea (HP:0002570)2.26654492
83Acanthocytosis (HP:0001927)2.24755909
84Dysostosis multiplex (HP:0000943)2.24700630
85Hypoplasia of the thymus (HP:0000778)2.24689240
86Increased mean platelet volume (HP:0011877)2.24171225
87Ketoacidosis (HP:0001993)2.23768926
88Granulocytopenia (HP:0001913)2.22931289
89Mitral stenosis (HP:0001718)2.22426849
90Abnormality of glycine metabolism (HP:0010895)2.22345290
91Abnormality of serine family amino acid metabolism (HP:0010894)2.22345290
92Urticaria (HP:0001025)2.21264080
93Recurrent fungal infections (HP:0002841)2.21217784
94Keratoconjunctivitis (HP:0001096)2.20797722
95IgM deficiency (HP:0002850)2.20514428
96Periodontitis (HP:0000704)2.20217957
97Glomerulonephritis (HP:0000099)2.19790694
98Menorrhagia (HP:0000132)2.18596045
99Abnormality of T cell physiology (HP:0011840)2.17426665
100Abnormality of nucleobase metabolism (HP:0010932)2.17247974
101Hypergammaglobulinemia (HP:0010702)2.17092280
102Joint swelling (HP:0001386)2.16916272
103Leukocytosis (HP:0001974)2.16616062
104Interstitial pulmonary disease (HP:0006530)2.14311967
105Hypoglycemic seizures (HP:0002173)2.14025523
106Arterial thrombosis (HP:0004420)2.11176356
107Hyperglycinemia (HP:0002154)2.10095481
108Vacuolated lymphocytes (HP:0001922)2.09817587
109Spondylolisthesis (HP:0003302)2.08764107
110Myositis (HP:0100614)2.07796356
111Recurrent bacterial skin infections (HP:0005406)2.07781919
112Abnormal delayed hypersensitivity skin test (HP:0002963)2.07241441
113Peritonitis (HP:0002586)2.06694315
114Nasal polyposis (HP:0100582)2.06196737
115Abnormality of the nasal mucosa (HP:0000433)2.05266668
116Abnormality of purine metabolism (HP:0004352)2.05107042
117Viral hepatitis (HP:0006562)2.04328851
118Impaired platelet aggregation (HP:0003540)2.04258134
119Abnormal platelet function (HP:0011869)2.04258134
120Abnormality of cells of the lymphoid lineage (HP:0012140)2.04025668
121Spontaneous abortion (HP:0005268)2.02449167
122Amyloidosis (HP:0011034)2.01583944
123Lymphopenia (HP:0001888)2.01132738
124Mucopolysacchariduria (HP:0008155)2.00293389
125Urinary glycosaminoglycan excretion (HP:0003541)2.00293389
126Pancreatitis (HP:0001733)2.00201977
127Hemorrhage of the eye (HP:0011885)1.99049539
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96879606
129Gastrointestinal infarctions (HP:0005244)1.96699885
130Colitis (HP:0002583)1.95775331
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.95513246
132Osteolytic defects of the hand bones (HP:0009699)1.95513246
133Increased IgM level (HP:0003496)1.95489840
134Verrucae (HP:0200043)1.94613448
135Papilloma (HP:0012740)1.94613448
136Recurrent skin infections (HP:0001581)1.93874702
137Eosinophilia (HP:0001880)1.92757743
138Inflammation of the large intestine (HP:0002037)1.92711922
139Abnormality of the peritoneum (HP:0002585)1.92558387
140Spastic diplegia (HP:0001264)1.92194945
141Hematochezia (HP:0002573)1.91210211
142Increased cerebral lipofuscin (HP:0011813)1.91162519
143Gastrointestinal inflammation (HP:0004386)1.91022806
144Polycythemia (HP:0001901)1.90966215
145Prolonged bleeding time (HP:0003010)1.90655420
146Emphysema (HP:0002097)1.88908636
147Skin nodule (HP:0200036)1.88367400
148Pustule (HP:0200039)1.87789777
149Vasculitis (HP:0002633)1.87615195
150Skin rash (HP:0000988)1.85825542
151Abnormality of iron homeostasis (HP:0011031)1.85676611
152Abnormality of transition element cation homeostasis (HP:0011030)1.85650744
153Chronic diarrhea (HP:0002028)1.85135637
154Skin ulcer (HP:0200042)1.84900250
155Recurrent abscess formation (HP:0002722)1.84593084
156Restrictive lung disease (HP:0002091)1.83889451
157Purpura (HP:0000979)1.83686213
158Fatigue (HP:0012378)1.82782907
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82392101
160Abnormality of polysaccharide metabolism (HP:0011012)1.82392101
161Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82392101
162Loss of speech (HP:0002371)1.79794671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.48446417
2PRPF4B3.11777772
3RIPK43.04650349
4FGFR42.95176418
5ERN12.93602794
6TYK22.65289546
7BCKDK2.56140312
8JAK32.50450726
9TXK2.37783355
10TAOK32.31854142
11SIK12.23633344
12PKN22.21594447
13MAP3K142.12895611
14FRK2.07594044
15ZAP701.99088508
16IKBKE1.98552849
17FLT31.95468344
18TBK11.93579010
19TGFBR21.92818183
20JAK11.89744394
21TRIB31.81451928
22KIT1.80743309
23LMTK21.78422392
24ITK1.72476568
25BTK1.70534904
26FES1.68450831
27FGFR31.67965418
28MAP2K31.61616839
29STK101.56195506
30MAP3K101.54162740
31EEF2K1.50017022
32TEC1.48304960
33IRAK31.45420655
34GRK61.41937147
35BLK1.40040724
36KDR1.39137360
37IRAK41.37933950
38CSF1R1.37732362
39EPHB11.37025354
40PTK61.33455919
41CSK1.27011529
42NEK91.24195724
43TESK21.21880714
44JAK21.21722003
45IKBKB1.20098587
46INSRR1.18574428
47MAP3K11.16295018
48LRRK21.14882451
49BMPR21.12580420
50CHUK1.11417205
51CDC42BPA1.10837412
52CDK121.09148611
53MAP3K31.08276394
54SYK1.06684931
55SIK31.06203297
56MAPK111.03326034
57EIF2AK31.02511603
58RIPK11.02137208
59KSR21.01628476
60LCK1.00220522
61MAP3K20.98617336
62MST1R0.97240445
63RPS6KA40.96806955
64MAPK70.89870472
65NLK0.89598111
66EPHA30.88070405
67PRKG20.86405855
68MAPK120.85499510
69FGR0.85464587
70NME20.82617697
71HCK0.82470918
72TGFBR10.81988517
73CDK60.81635199
74PIK3CG0.81211851
75PIM10.79952885
76SMG10.78935413
77CDK40.75913308
78LYN0.74267080
79TIE10.74009692
80PDPK10.73351217
81STK40.69354678
82CAMK1D0.67376667
83NUAK10.64803357
84TNK20.62982370
85TTN0.61456674
86PDGFRB0.60839941
87RET0.59078833
88YES10.59022074
89PDGFRA0.58630560
90CLK10.58243050
91PRKCQ0.57549255
92MARK20.56310942
93CAMKK20.55323369
94RPS6KB20.54609607
95TRPM70.52774458
96MELK0.51914297
97MAP3K70.51378740
98MAPK40.50944546
99TAOK20.49011533
100IRAK10.48994492
101HIPK20.48259410
102PASK0.46645850
103PRKAA20.46550008
104MAP3K130.46414695
105FGFR20.44747451
106MATK0.44622272
107FYN0.44267611
108IGF1R0.42885637
109EGFR0.41893356
110MAP3K110.41485392
111WNK10.41377386
112STK240.40579926
113SCYL20.40369194
114MOS0.38420293
115MST40.38212813
116MAPK150.38140791
117ICK0.37971342
118RPS6KC10.37548886
119RPS6KL10.37548886
120GRK70.37473664
121STK30.35500977
122MAP3K80.34194160
123RPS6KA60.34008807
124ACVR1B0.31187765
125PDK10.31045245
126ABL10.30388573
127ERBB20.29351485
128MAPK30.29092858
129PRKCH0.27760417
130SGK30.27213268
131PRKCD0.27207928
132MAPKAPK20.26619793
133MARK30.26077094
134PAK40.25512110

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.76981701
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.05202046
3Nitrogen metabolism_Homo sapiens_hsa009102.99722064
4Complement and coagulation cascades_Homo sapiens_hsa046102.62085751
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61737488
6Autoimmune thyroid disease_Homo sapiens_hsa053202.47702034
7Staphylococcus aureus infection_Homo sapiens_hsa051502.40465484
8Tryptophan metabolism_Homo sapiens_hsa003802.36497538
9Arginine biosynthesis_Homo sapiens_hsa002202.35975948
10Fatty acid degradation_Homo sapiens_hsa000712.35320102
11Caffeine metabolism_Homo sapiens_hsa002322.32187596
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27382048
13Asthma_Homo sapiens_hsa053102.06294567
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99571844
15Type I diabetes mellitus_Homo sapiens_hsa049401.88745280
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85062156
17Selenocompound metabolism_Homo sapiens_hsa004501.83268219
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82150779
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70628778
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.70623705
21Viral myocarditis_Homo sapiens_hsa054161.70433854
22Peroxisome_Homo sapiens_hsa041461.70322739
23PPAR signaling pathway_Homo sapiens_hsa033201.68183978
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67462280
25Histidine metabolism_Homo sapiens_hsa003401.57394096
26Tuberculosis_Homo sapiens_hsa051521.56354559
27ABC transporters_Homo sapiens_hsa020101.54114767
28Chemical carcinogenesis_Homo sapiens_hsa052041.52407168
29Fatty acid metabolism_Homo sapiens_hsa012121.48097188
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46030742
31Primary immunodeficiency_Homo sapiens_hsa053401.45809864
32Propanoate metabolism_Homo sapiens_hsa006401.45208871
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.39845207
34Starch and sucrose metabolism_Homo sapiens_hsa005001.31738107
35beta-Alanine metabolism_Homo sapiens_hsa004101.31723133
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31482249
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23277114
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19811353
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.19761834
40Retinol metabolism_Homo sapiens_hsa008301.17085680
41Folate biosynthesis_Homo sapiens_hsa007901.16789463
42Bile secretion_Homo sapiens_hsa049761.14099652
43Sulfur metabolism_Homo sapiens_hsa009201.12722657
44Antigen processing and presentation_Homo sapiens_hsa046121.11555863
45Butanoate metabolism_Homo sapiens_hsa006501.11496357
46Chemokine signaling pathway_Homo sapiens_hsa040621.11467547
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.11278259
48Non-small cell lung cancer_Homo sapiens_hsa052231.10466330
49Chronic myeloid leukemia_Homo sapiens_hsa052201.10221664
50Phenylalanine metabolism_Homo sapiens_hsa003601.09263958
51Pancreatic cancer_Homo sapiens_hsa052121.08987862
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.06788182
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06443214
54One carbon pool by folate_Homo sapiens_hsa006701.05983589
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.04756548
56Platelet activation_Homo sapiens_hsa046111.04171297
57Leishmaniasis_Homo sapiens_hsa051401.03858582
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03596537
59Fat digestion and absorption_Homo sapiens_hsa049750.97695025
60Measles_Homo sapiens_hsa051620.95140285
61Lysine degradation_Homo sapiens_hsa003100.93357401
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92064318
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90973903
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89978352
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89914007
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89002427
67Rheumatoid arthritis_Homo sapiens_hsa053230.88728590
68Lysosome_Homo sapiens_hsa041420.87582777
69Phagosome_Homo sapiens_hsa041450.86529815
70Tyrosine metabolism_Homo sapiens_hsa003500.85895502
71Prolactin signaling pathway_Homo sapiens_hsa049170.85544360
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.84895950
73Carbon metabolism_Homo sapiens_hsa012000.83137346
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.83038542
75Pentose phosphate pathway_Homo sapiens_hsa000300.82950920
76Biosynthesis of amino acids_Homo sapiens_hsa012300.79816483
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74241919
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73827582
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73157918
80Vitamin digestion and absorption_Homo sapiens_hsa049770.72826525
81African trypanosomiasis_Homo sapiens_hsa051430.72571975
82Pyruvate metabolism_Homo sapiens_hsa006200.72455249
83Amoebiasis_Homo sapiens_hsa051460.72226185
84Legionellosis_Homo sapiens_hsa051340.71992027
85Sulfur relay system_Homo sapiens_hsa041220.71763753
86Osteoclast differentiation_Homo sapiens_hsa043800.70968774
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70957682
88VEGF signaling pathway_Homo sapiens_hsa043700.68090002
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67480541
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66832829
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.66280063
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65932777
93B cell receptor signaling pathway_Homo sapiens_hsa046620.65906824
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64375209
95Renal cell carcinoma_Homo sapiens_hsa052110.64163198
96Viral carcinogenesis_Homo sapiens_hsa052030.63468087
97Fatty acid elongation_Homo sapiens_hsa000620.62916299
98Shigellosis_Homo sapiens_hsa051310.62867478
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62134234
100Allograft rejection_Homo sapiens_hsa053300.61899377
101Insulin resistance_Homo sapiens_hsa049310.61716399
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.61054879
103HTLV-I infection_Homo sapiens_hsa051660.57916524
104Herpes simplex infection_Homo sapiens_hsa051680.57192597
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56490273
106Dorso-ventral axis formation_Homo sapiens_hsa043200.56438901
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.55706293
108Pertussis_Homo sapiens_hsa051330.55346262
109Graft-versus-host disease_Homo sapiens_hsa053320.54715246
110Toxoplasmosis_Homo sapiens_hsa051450.54492187
111Hematopoietic cell lineage_Homo sapiens_hsa046400.54352794
112Small cell lung cancer_Homo sapiens_hsa052220.53994051
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53990530
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.53650520
115T cell receptor signaling pathway_Homo sapiens_hsa046600.53383783
116Salmonella infection_Homo sapiens_hsa051320.52277483
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51884674
118Glycerolipid metabolism_Homo sapiens_hsa005610.51512195
119Influenza A_Homo sapiens_hsa051640.51047720
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.50398237
121FoxO signaling pathway_Homo sapiens_hsa040680.48777781
122Prostate cancer_Homo sapiens_hsa052150.48724843
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48101991
124Endometrial cancer_Homo sapiens_hsa052130.47258976
125Arginine and proline metabolism_Homo sapiens_hsa003300.45649574
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.45026737
127Focal adhesion_Homo sapiens_hsa045100.44910967
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44715823
129GnRH signaling pathway_Homo sapiens_hsa049120.44544216
130Choline metabolism in cancer_Homo sapiens_hsa052310.44410425
131Malaria_Homo sapiens_hsa051440.43588376
132Systemic lupus erythematosus_Homo sapiens_hsa053220.43523552
133Notch signaling pathway_Homo sapiens_hsa043300.43507969
134Other glycan degradation_Homo sapiens_hsa005110.43494776
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43397104
136Glutathione metabolism_Homo sapiens_hsa004800.43351430
137Fatty acid biosynthesis_Homo sapiens_hsa000610.42951381
138Galactose metabolism_Homo sapiens_hsa000520.42457876
139Epstein-Barr virus infection_Homo sapiens_hsa051690.41451411
140Hepatitis C_Homo sapiens_hsa051600.41406552
141TNF signaling pathway_Homo sapiens_hsa046680.40651207
142HIF-1 signaling pathway_Homo sapiens_hsa040660.40438911
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40438562
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40282567
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39774053
146Apoptosis_Homo sapiens_hsa042100.38154289
147Thyroid cancer_Homo sapiens_hsa052160.38047413
148mTOR signaling pathway_Homo sapiens_hsa041500.38015778
149Endocytosis_Homo sapiens_hsa041440.35930092
150Prion diseases_Homo sapiens_hsa050200.35747742
151Glioma_Homo sapiens_hsa052140.35115551
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34720583
153Acute myeloid leukemia_Homo sapiens_hsa052210.33659251
154Renin-angiotensin system_Homo sapiens_hsa046140.33615107
155NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33058057
156Hepatitis B_Homo sapiens_hsa051610.31630592

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