ERAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.78641701
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.64439059
3* antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61592695
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.50544143
5negative regulation of cell killing (GO:0031342)5.50544143
6negative T cell selection (GO:0043383)5.46939555
7* antigen processing and presentation of endogenous antigen (GO:0019883)5.34930418
8* antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.32569742
9negative thymic T cell selection (GO:0045060)5.26693464
10regulation of B cell receptor signaling pathway (GO:0050855)4.82480993
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.74526639
12positive T cell selection (GO:0043368)4.70089247
13positive thymic T cell selection (GO:0045059)4.62429505
14regulation of gamma-delta T cell differentiation (GO:0045586)4.42522245
15regulation of gamma-delta T cell activation (GO:0046643)4.32031729
16response to interleukin-15 (GO:0070672)4.31035431
17cellular response to interleukin-15 (GO:0071350)4.23427102
18T cell selection (GO:0045058)4.19708985
19T cell migration (GO:0072678)4.19432032
20thymic T cell selection (GO:0045061)4.07045787
21regulation of alpha-beta T cell proliferation (GO:0046640)4.04765599
22activated T cell proliferation (GO:0050798)3.90858792
23B cell receptor signaling pathway (GO:0050853)3.85533152
24regulation of regulatory T cell differentiation (GO:0045589)3.79605389
25positive regulation of alpha-beta T cell proliferation (GO:0046641)3.76883721
26negative regulation of T cell mediated immunity (GO:0002710)3.75442488
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72154642
28response to type I interferon (GO:0034340)3.62624529
29positive regulation of granulocyte differentiation (GO:0030854)3.62037859
30cellular response to type I interferon (GO:0071357)3.60679207
31type I interferon signaling pathway (GO:0060337)3.60679207
32regulation of T cell mediated cytotoxicity (GO:0001914)3.57768939
33leukocyte aggregation (GO:0070486)3.52983587
34regulation of T cell tolerance induction (GO:0002664)3.50524548
35regulation of natural killer cell mediated immunity (GO:0002715)3.49294091
36regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.49294091
37regulation of B cell differentiation (GO:0045577)3.46318198
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.45836512
39positive regulation of B cell differentiation (GO:0045579)3.41770146
40negative regulation of lymphocyte mediated immunity (GO:0002707)3.38756522
41tolerance induction (GO:0002507)3.38122221
42immunoglobulin mediated immune response (GO:0016064)3.36330023
43antigen processing and presentation via MHC class Ib (GO:0002475)3.33680091
44regulation of leukocyte mediated cytotoxicity (GO:0001910)3.26327040
45interferon-gamma-mediated signaling pathway (GO:0060333)3.22752842
46regulation of tolerance induction (GO:0002643)3.21019310
47positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.20312046
48antigen receptor-mediated signaling pathway (GO:0050851)3.19229887
49detection of other organism (GO:0098543)3.17988846
50interferon-gamma production (GO:0032609)3.17623595
51detection of bacterium (GO:0016045)3.16552776
52positive regulation of tolerance induction (GO:0002645)3.15829680
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.09834055
54negative regulation of leukocyte mediated immunity (GO:0002704)3.09700830
55cellular extravasation (GO:0045123)3.09060064
56T cell receptor signaling pathway (GO:0050852)3.08056022
57macrophage activation involved in immune response (GO:0002281)3.08012809
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.05802360
59negative regulation of interleukin-12 production (GO:0032695)3.04428930
60regulation of cell killing (GO:0031341)3.04177779
61positive regulation of natural killer cell mediated immunity (GO:0002717)3.04062648
62T cell costimulation (GO:0031295)3.03912428
63positive regulation by symbiont of host defense response (GO:0052509)3.03669227
64modulation by symbiont of host defense response (GO:0052031)3.03669227
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03669227
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03669227
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.03669227
68modulation by symbiont of host immune response (GO:0052553)3.03669227
69regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03463541
70regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02106494
71mast cell activation (GO:0045576)3.01693611
72lymphocyte costimulation (GO:0031294)2.99347181
73positive regulation of cell killing (GO:0031343)2.96724163
74regulation of isotype switching to IgG isotypes (GO:0048302)2.96333095
75regulation of interferon-beta biosynthetic process (GO:0045357)2.95371380
76regulation of antigen processing and presentation (GO:0002577)2.93523495
77cytidine deamination (GO:0009972)2.92482792
78cytidine metabolic process (GO:0046087)2.92482792
79cytidine catabolic process (GO:0006216)2.92482792
80positive regulation of antigen processing and presentation (GO:0002579)2.92344900
81regulation of alpha-beta T cell activation (GO:0046634)2.91519803
82defense response to protozoan (GO:0042832)2.90259454
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89199344
84response to interferon-beta (GO:0035456)2.88773389
85NIK/NF-kappaB signaling (GO:0038061)2.88596345
86positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86349828
87negative regulation of innate immune response (GO:0045824)2.85732327
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.85596771
89B cell mediated immunity (GO:0019724)2.85353746
90cellular response to exogenous dsRNA (GO:0071360)2.83742838
91T cell proliferation (GO:0042098)2.82548913
92positive regulation of alpha-beta T cell activation (GO:0046635)2.82153326
93dendritic cell chemotaxis (GO:0002407)2.81626280
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81292793
95positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.80949652
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.79385664
97positive regulation of defense response to virus by host (GO:0002230)2.79381201
98alpha-beta T cell activation (GO:0046631)2.77747295
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.77419202
100regulation of T cell mediated immunity (GO:0002709)2.76880358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.38668029
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.75969682
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.46902553
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.96673425
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.93075632
6RUNX_20019798_ChIP-Seq_JUKART_Human3.66292121
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.48989948
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.39049166
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.23352786
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12514270
11* MYB_26560356_Chip-Seq_TH2_Human3.09932267
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.82139017
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70774139
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70370500
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.48917990
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45662859
17MYB_26560356_Chip-Seq_TH1_Human2.45154095
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38037561
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30654402
20MAF_26560356_Chip-Seq_TH1_Human2.19142026
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18829400
22SCL_19346495_ChIP-Seq_HPC-7_Human2.16172594
23* GATA3_27048872_Chip-Seq_THYMUS_Human2.13595369
24* SPI1_23547873_ChIP-Seq_NB4_Human2.09049390
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04504765
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02598453
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98509091
28UTX_26944678_Chip-Seq_JUKART_Human1.96676854
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92026224
30* GATA3_26560356_Chip-Seq_TH2_Human1.89265372
31VDR_24763502_ChIP-Seq_THP-1_Human1.74709908
32BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74499597
33* SPI1_23127762_ChIP-Seq_K562_Human1.67380743
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.66684021
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66468504
36VDR_24787735_ChIP-Seq_THP-1_Human1.64523281
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60728798
38Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57802631
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55992257
40MYC_22102868_ChIP-Seq_BL_Human1.55226480
41MAF_26560356_Chip-Seq_TH2_Human1.49494269
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49478509
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.48904252
44RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38567876
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38474950
46VDR_21846776_ChIP-Seq_THP-1_Human1.38009782
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35266872
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34116354
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30564623
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28814284
51GATA1_22025678_ChIP-Seq_K562_Human1.27202068
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26953875
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.26747715
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26528989
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24515323
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23982165
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20650091
58PU_27001747_Chip-Seq_BMDM_Mouse1.17451913
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.14113774
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12467212
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10755214
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10572619
63CIITA_25753668_ChIP-Seq_RAJI_Human1.08635108
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08201000
65TCF7_22412390_ChIP-Seq_EML_Mouse1.06239750
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05698596
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04060117
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03176827
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.02496349
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01802385
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98383153
72GATA1_19941826_ChIP-Seq_K562_Human0.95052572
73* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92462760
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91185118
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90362576
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88972169
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87844067
78KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87121910
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86189668
80SMRT_27268052_Chip-Seq_Bcells_Human0.84634887
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84599911
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82331582
83GATA2_19941826_ChIP-Seq_K562_Human0.81133342
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79335399
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78108446
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77306929
87BCL6_27268052_Chip-Seq_Bcells_Human0.77226754
88GATA3_26560356_Chip-Seq_TH1_Human0.75476894
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73301382
90* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73191697
91KDM2B_26808549_Chip-Seq_DND41_Human0.72133961
92PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70060837
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69803382
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.66345014
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.66223745
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65125606
97P300_27268052_Chip-Seq_Bcells_Human0.63901777
98* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63268953
99GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.62206601
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62015308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.22220639
2MP0005671_abnormal_response_to3.92045908
3MP0003724_increased_susceptibility_to3.82133475
4MP0003763_abnormal_thymus_physiology3.55560432
5MP0003436_decreased_susceptibility_to3.48977555
6MP0000685_abnormal_immune_system3.45504017
7MP0001800_abnormal_humoral_immune3.16977050
8MP0005387_immune_system_phenotype3.03716309
9MP0001790_abnormal_immune_system3.03716309
10MP0005000_abnormal_immune_tolerance3.01214194
11MP0009785_altered_susceptibility_to2.92871142
12MP0002723_abnormal_immune_serum2.69138029
13MP0005025_abnormal_response_to2.62379055
14MP0002452_abnormal_antigen_presenting2.57195921
15MP0002148_abnormal_hypersensitivity_rea2.53889832
16MP0002420_abnormal_adaptive_immunity2.53818562
17MP0001819_abnormal_immune_cell2.51123671
18MP0006082_CNS_inflammation2.49736748
19MP0002419_abnormal_innate_immunity2.46021198
20MP0002166_altered_tumor_susceptibility2.33939206
21MP0010155_abnormal_intestine_physiology2.26849514
22MP0009333_abnormal_splenocyte_physiolog2.20883647
23MP0003300_gastrointestinal_ulcer2.18852564
24MP0002398_abnormal_bone_marrow2.09079104
25MP0002405_respiratory_system_inflammati2.07521050
26MP0003303_peritoneal_inflammation2.06191417
27MP0000716_abnormal_immune_system2.02138996
28MP0004947_skin_inflammation1.92315893
29MP0003866_abnormal_defecation1.86810612
30MP0001873_stomach_inflammation1.82609243
31MP0001533_abnormal_skeleton_physiology1.80062713
32MP0001845_abnormal_inflammatory_respons1.78971212
33MP0000689_abnormal_spleen_morphology1.77847548
34MP0002006_tumorigenesis1.76063403
35MP0005464_abnormal_platelet_physiology1.73377753
36MP0002138_abnormal_hepatobiliary_system1.70702743
37MP0000703_abnormal_thymus_morphology1.70240626
38MP0002722_abnormal_immune_system1.69852188
39MP0002396_abnormal_hematopoietic_system1.62603985
40MP0002429_abnormal_blood_cell1.57354114
41MP0000465_gastrointestinal_hemorrhage1.57094238
42MP0005310_abnormal_salivary_gland1.47337990
43MP0002933_joint_inflammation1.44617409
44MP0008469_abnormal_protein_level1.44255904
45MP0003191_abnormal_cellular_cholesterol1.39193806
46MP0003045_fibrosis1.31801369
47MP0003183_abnormal_peptide_metabolism1.31402109
48MP0004381_abnormal_hair_follicle1.29657688
49MP0002998_abnormal_bone_remodeling1.28228816
50MP0005360_urolithiasis1.21369838
51MP0000858_altered_metastatic_potential1.20881573
52MP0001853_heart_inflammation1.17997796
53MP0009764_decreased_sensitivity_to1.17956469
54MP0001851_eye_inflammation1.13146574
55MP0002009_preneoplasia1.12958513
56MP0008260_abnormal_autophagy1.05324574
57MP0003448_altered_tumor_morphology1.02983826
58MP0005166_decreased_susceptibility_to1.02584656
59MP0003172_abnormal_lysosome_physiology1.01369433
60MP0004883_abnormal_blood_vessel1.01260797
61MP0003828_pulmonary_edema0.98760769
62MP0005075_abnormal_melanosome_morpholog0.97262736
63MP0004808_abnormal_hematopoietic_stem0.97122851
64MP0009763_increased_sensitivity_to0.93965058
65MP0005164_abnormal_response_to0.93768219
66MP0000249_abnormal_blood_vessel0.88404766
67MP0001986_abnormal_taste_sensitivity0.87313567
68MP0000569_abnormal_digit_pigmentation0.87052380
69MP0000604_amyloidosis0.86482765
70MP0001663_abnormal_digestive_system0.84216025
71MP0009840_abnormal_foam_cell0.83960340
72MP0003252_abnormal_bile_duct0.81460129
73MP0005390_skeleton_phenotype0.76716277
74MP0002877_abnormal_melanocyte_morpholog0.69557194
75MP0009765_abnormal_xenobiotic_induced0.68004975
76MP0000015_abnormal_ear_pigmentation0.66808842
77MP0002019_abnormal_tumor_incidence0.66415896
78MP0005058_abnormal_lysosome_morphology0.65766053
79MP0003795_abnormal_bone_structure0.65550340
80MP0002136_abnormal_kidney_physiology0.63736264
81MP0000490_abnormal_crypts_of0.63519302
82MP0003075_altered_response_to0.61499049
83MP0002132_abnormal_respiratory_system0.61294412
84MP0005397_hematopoietic_system_phenotyp0.60198074
85MP0001545_abnormal_hematopoietic_system0.60198074
86MP0001765_abnormal_ion_homeostasis0.59174427
87MP0009278_abnormal_bone_marrow0.57944961
88MP0003806_abnormal_nucleotide_metabolis0.57678164
89MP0000609_abnormal_liver_physiology0.57474742
90MP0002139_abnormal_hepatobiliary_system0.57164520
91MP0003656_abnormal_erythrocyte_physiolo0.56291659
92MP0000343_altered_response_to0.55823927
93MP0005451_abnormal_body_composition0.55727775
94MP0004782_abnormal_surfactant_physiolog0.55478827
95MP0002277_abnormal_respiratory_mucosa0.54392735
96MP0003091_abnormal_cell_migration0.53366057
97MP0003690_abnormal_glial_cell0.53039880
98MP0002693_abnormal_pancreas_physiology0.51996727
99MP0009643_abnormal_urine_homeostasis0.50794126
100MP0005319_abnormal_enzyme/_coenzyme0.48869204

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)5.38511030
2T lymphocytopenia (HP:0005403)5.29157822
3Abnormal delayed hypersensitivity skin test (HP:0002963)4.82019663
4Eczematoid dermatitis (HP:0000976)4.52959766
5Elevated erythrocyte sedimentation rate (HP:0003565)4.38456317
6Autoimmune hemolytic anemia (HP:0001890)4.33394408
7Recurrent fungal infections (HP:0002841)4.27907694
8Abnormality of T cells (HP:0002843)4.23524176
9Myositis (HP:0100614)4.21505051
10Panhypogammaglobulinemia (HP:0003139)3.98053342
11Severe combined immunodeficiency (HP:0004430)3.87388479
12Retrobulbar optic neuritis (HP:0100654)3.82215777
13Optic neuritis (HP:0100653)3.82215777
14Recurrent cutaneous fungal infections (HP:0011370)3.80269053
15Chronic mucocutaneous candidiasis (HP:0002728)3.80269053
16Orchitis (HP:0100796)3.79264307
17Recurrent viral infections (HP:0004429)3.78689056
18Recurrent abscess formation (HP:0002722)3.75394346
19Vasculitis (HP:0002633)3.72492565
20IgG deficiency (HP:0004315)3.71587992
21Recurrent bacterial skin infections (HP:0005406)3.71450757
22Meningitis (HP:0001287)3.68008161
23Pustule (HP:0200039)3.65005438
24Recurrent bronchitis (HP:0002837)3.61405214
25Agammaglobulinemia (HP:0004432)3.59882310
26Chronic diarrhea (HP:0002028)3.53833068
27Encephalitis (HP:0002383)3.53258228
28Abnormality of T cell physiology (HP:0011840)3.53161701
29Stomatitis (HP:0010280)3.51102290
30Eosinophilia (HP:0001880)3.48547762
31Abnormality of eosinophils (HP:0001879)3.47037489
32Spontaneous hematomas (HP:0007420)3.44744336
33Increased IgM level (HP:0003496)3.40842511
34Granulocytopenia (HP:0001913)3.40398135
35Autoimmune thrombocytopenia (HP:0001973)3.39581187
36Gastrointestinal infarctions (HP:0005244)3.38301055
37Pulmonary infiltrates (HP:0002113)3.37752096
38Mediastinal lymphadenopathy (HP:0100721)3.24819326
39Leukocytosis (HP:0001974)3.24562292
40Abnormality of B cell number (HP:0010975)3.21136867
41Recurrent skin infections (HP:0001581)3.14640443
42Abnormality of macrophages (HP:0004311)3.13573509
43Thyroiditis (HP:0100646)3.06839596
44Hemoptysis (HP:0002105)3.01663491
45Combined immunodeficiency (HP:0005387)3.01107768
46Inflammation of the large intestine (HP:0002037)2.90091107
47Keratoconjunctivitis sicca (HP:0001097)2.81701054
48Increased IgE level (HP:0003212)2.78770533
49Chronic obstructive pulmonary disease (HP:0006510)2.75270716
50Obstructive lung disease (HP:0006536)2.75270716
51Gastrointestinal inflammation (HP:0004386)2.75107070
52Colitis (HP:0002583)2.74588106
53Abnormality of cells of the lymphoid lineage (HP:0012140)2.74023776
54Hypergammaglobulinemia (HP:0010702)2.64199697
55B lymphocytopenia (HP:0010976)2.64140451
56Lymphopenia (HP:0001888)2.63433778
57Keratoconjunctivitis (HP:0001096)2.63188749
58IgM deficiency (HP:0002850)2.61727338
59Recurrent gram-negative bacterial infections (HP:0005420)2.60567579
60Chest pain (HP:0100749)2.59293789
61Hypochromic anemia (HP:0001931)2.58924122
62Pulmonary embolism (HP:0002204)2.54275986
63Hypoplasia of the thymus (HP:0000778)2.51783254
64Gastrointestinal stroma tumor (HP:0100723)2.49624824
65Gingivitis (HP:0000230)2.47632111
66Papilloma (HP:0012740)2.46536290
67Verrucae (HP:0200043)2.46536290
68Hematochezia (HP:0002573)2.42308738
69Urticaria (HP:0001025)2.38665666
70Epistaxis (HP:0000421)2.38369160
71Chronic otitis media (HP:0000389)2.37861703
72Stomach cancer (HP:0012126)2.36278470
73IgA deficiency (HP:0002720)2.35472178
74Prolonged bleeding time (HP:0003010)2.31750562
75Abnormality of the prostate (HP:0008775)2.28312435
76Arterial thrombosis (HP:0004420)2.27088513
77Joint swelling (HP:0001386)2.26962092
78Hypoproteinemia (HP:0003075)2.23810103
79Abnormality of the pleura (HP:0002103)2.23440173
80Gingival bleeding (HP:0000225)2.22170537
81Lymphoma (HP:0002665)2.21281784
82Cellulitis (HP:0100658)2.19470167
83Osteomyelitis (HP:0002754)2.16198148
84Premature loss of primary teeth (HP:0006323)2.13911924
85Gangrene (HP:0100758)2.10264407
86Hypochromic microcytic anemia (HP:0004840)2.06591007
87Microcytic anemia (HP:0001935)2.05692668
88Alveolar cell carcinoma (HP:0006519)2.03816778
89Bronchitis (HP:0012387)2.02548091
90Skin rash (HP:0000988)2.00468994
91Anorexia (HP:0002039)1.96075870
92Neoplasm of the tracheobronchial system (HP:0100552)1.93512425
93Recurrent sinusitis (HP:0011108)1.93385802
94Restrictive lung disease (HP:0002091)1.91490773
95Skin ulcer (HP:0200042)1.89306374
96Dysostosis multiplex (HP:0000943)1.88462707
97Sepsis (HP:0100806)1.88458217
98Glomerulopathy (HP:0100820)1.88035490
99Viral hepatitis (HP:0006562)1.83096998
100Polyneuropathy (HP:0001271)1.81032457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.24668630
2TXK3.90440577
3TAOK33.49604482
4TYK22.77522592
5RIPK42.72335300
6IRAK42.59822260
7MAP3K142.39284272
8FES2.36256101
9KIT2.32380360
10IKBKE2.29405344
11JAK12.29081899
12JAK32.26816729
13ITK2.20973507
14GRK62.13243810
15ZAP702.12697132
16BTK2.08484309
17SYK2.04450115
18ERN12.02586023
19BLK1.98213427
20TEC1.94963102
21CSK1.86564810
22TBK11.74317644
23MAP3K131.74134117
24PRPF4B1.70498822
25MAP2K31.56293778
26LCK1.53952063
27FGFR41.51394796
28HCK1.46594226
29IKBKB1.45828012
30FGFR31.44963901
31PIK3CG1.34218228
32NLK1.33161702
33TGFBR21.32360334
34LYN1.30995935
35CSF1R1.27577754
36EPHB11.18762575
37CAMKK21.16555043
38TRPM71.12647280
39MARK31.11912975
40IRAK11.09774014
41BMPR21.09415186
42MAP3K101.06819890
43JAK21.05155580
44PRKCQ0.98372185
45TLK10.98186663
46HIPK20.96327981
47MAPK70.95083063
48TNK20.91512630
49MAPK110.91355208
50STK100.86292593
51FRK0.86189718
52EPHA30.84948109
53ACVR1B0.84871132
54KDR0.84167354
55TESK20.82347977
56GRK70.80364081
57PIM10.80280107
58CDC42BPA0.78893105
59SCYL20.77574025
60NEK90.76804316
61PDK10.72376172
62MAP2K20.68642195
63MAP3K30.67568907
64MATK0.67018746
65MAP2K60.58745841
66PIK3CA0.58612856
67MAPK120.56675035
68FGR0.54867771
69CDK40.51866111
70CHUK0.47217646
71MAP3K10.46382255
72FYN0.45275437
73ADRBK20.42934532
74CAMKK10.42724053
75MAPKAPK20.42704555
76PTK2B0.42567588
77SIK30.41946820
78PRKCH0.41396625
79CDK60.38576189
80ABL10.37279184
81MAP3K110.37057162
82PDPK10.36629540
83IGF1R0.35701945
84NUAK10.35691318
85MAP3K70.34776553
86MST1R0.34247220
87PDGFRB0.33114080
88SGK30.32684613
89RIPK10.31773065
90MELK0.30853864
91PRKD20.30764347
92MAP3K20.30084358
93SGK20.29114280
94EIF2AK30.27171819
95GRK50.26196769
96CDK190.25762387
97RET0.25677127
98MAPK30.25561981
99EGFR0.23423824
100MAPKAPK30.23374435

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.86900054
2Graft-versus-host disease_Homo sapiens_hsa053323.56510193
3Allograft rejection_Homo sapiens_hsa053303.48209408
4Autoimmune thyroid disease_Homo sapiens_hsa053203.25130800
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.92408293
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.61187069
7Leishmaniasis_Homo sapiens_hsa051402.55997010
8Type I diabetes mellitus_Homo sapiens_hsa049402.54020279
9Antigen processing and presentation_Homo sapiens_hsa046122.47274965
10Asthma_Homo sapiens_hsa053102.42722460
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.32546444
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.26759373
13Staphylococcus aureus infection_Homo sapiens_hsa051502.26303200
14Hematopoietic cell lineage_Homo sapiens_hsa046402.16261263
15T cell receptor signaling pathway_Homo sapiens_hsa046602.15245210
16Measles_Homo sapiens_hsa051622.10131246
17Osteoclast differentiation_Homo sapiens_hsa043802.01873855
18B cell receptor signaling pathway_Homo sapiens_hsa046621.94473033
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91278647
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76467002
21Viral myocarditis_Homo sapiens_hsa054161.72171309
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67969023
23Toxoplasmosis_Homo sapiens_hsa051451.61899735
24Herpes simplex infection_Homo sapiens_hsa051681.56057309
25Influenza A_Homo sapiens_hsa051641.53737066
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53210671
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.50868818
28Tuberculosis_Homo sapiens_hsa051521.49290760
29Malaria_Homo sapiens_hsa051441.43505470
30TNF signaling pathway_Homo sapiens_hsa046681.38243115
31Rheumatoid arthritis_Homo sapiens_hsa053231.37146795
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28169882
33Chemokine signaling pathway_Homo sapiens_hsa040621.23042331
34Acute myeloid leukemia_Homo sapiens_hsa052211.17404813
35Pertussis_Homo sapiens_hsa051331.14967429
36African trypanosomiasis_Homo sapiens_hsa051431.14439343
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11883629
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10933410
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06202946
40Hepatitis C_Homo sapiens_hsa051601.02253621
41Hepatitis B_Homo sapiens_hsa051611.01521332
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95347019
43Legionellosis_Homo sapiens_hsa051340.95144952
44Non-small cell lung cancer_Homo sapiens_hsa052230.91730175
45Platelet activation_Homo sapiens_hsa046110.90944400
46Apoptosis_Homo sapiens_hsa042100.89025375
47Other glycan degradation_Homo sapiens_hsa005110.80013455
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.79658614
49Shigellosis_Homo sapiens_hsa051310.72777034
50Pancreatic cancer_Homo sapiens_hsa052120.71364200
51Caffeine metabolism_Homo sapiens_hsa002320.69452959
52Prolactin signaling pathway_Homo sapiens_hsa049170.68873805
53Epstein-Barr virus infection_Homo sapiens_hsa051690.67102852
54Phagosome_Homo sapiens_hsa041450.63886638
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63371645
56Systemic lupus erythematosus_Homo sapiens_hsa053220.61966209
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.61505297
58Viral carcinogenesis_Homo sapiens_hsa052030.60682046
59HTLV-I infection_Homo sapiens_hsa051660.59965399
60Dorso-ventral axis formation_Homo sapiens_hsa043200.59944285
61Renin-angiotensin system_Homo sapiens_hsa046140.59510921
62Chronic myeloid leukemia_Homo sapiens_hsa052200.56434442
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50798030
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48860990
65Linoleic acid metabolism_Homo sapiens_hsa005910.48644982
66ABC transporters_Homo sapiens_hsa020100.47072079
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45460366
68FoxO signaling pathway_Homo sapiens_hsa040680.44389353
69Insulin resistance_Homo sapiens_hsa049310.43944533
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42070833
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.41279647
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41030011
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.40628296
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40308848
75Small cell lung cancer_Homo sapiens_hsa052220.39904251
76Lysosome_Homo sapiens_hsa041420.39692284
77VEGF signaling pathway_Homo sapiens_hsa043700.38868354
78Salmonella infection_Homo sapiens_hsa051320.38837002
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.37970272
80Regulation of autophagy_Homo sapiens_hsa041400.37649445
81Complement and coagulation cascades_Homo sapiens_hsa046100.36237368
82Arachidonic acid metabolism_Homo sapiens_hsa005900.33670928
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.33486753
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33277450
85Renal cell carcinoma_Homo sapiens_hsa052110.30604503
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28100007
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27716723
88Glycerolipid metabolism_Homo sapiens_hsa005610.26441759
89Endocytosis_Homo sapiens_hsa041440.25534932
90Amoebiasis_Homo sapiens_hsa051460.24622012
91Prostate cancer_Homo sapiens_hsa052150.23869405
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.22498105
93MAPK signaling pathway_Homo sapiens_hsa040100.21999387
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21945528
95Choline metabolism in cancer_Homo sapiens_hsa052310.21759042
96Renin secretion_Homo sapiens_hsa049240.20731023
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.19909694
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18816577
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.17742733
100mTOR signaling pathway_Homo sapiens_hsa041500.14586175

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