ERBB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.80476429
2hemidesmosome assembly (GO:0031581)5.51868009
3peptidyl-proline hydroxylation (GO:0019511)5.23961497
4stress granule assembly (GO:0034063)5.18312286
5protein hydroxylation (GO:0018126)4.52980126
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.48009596
7epithelial cell-cell adhesion (GO:0090136)4.36484542
84-hydroxyproline metabolic process (GO:0019471)4.35443601
9positive regulation of keratinocyte differentiation (GO:0045618)4.28153647
10paraxial mesoderm development (GO:0048339)4.23943728
11pattern specification involved in kidney development (GO:0061004)4.15195734
12regulation of hippo signaling (GO:0035330)4.02545270
13semaphorin-plexin signaling pathway (GO:0071526)4.01605576
14gap junction assembly (GO:0016264)4.00582157
15proline metabolic process (GO:0006560)3.85336683
16establishment of apical/basal cell polarity (GO:0035089)3.80091812
17positive regulation of epidermal cell differentiation (GO:0045606)3.75765319
18negative regulation of smooth muscle cell migration (GO:0014912)3.72278089
19branching involved in mammary gland duct morphogenesis (GO:0060444)3.71006539
20one-carbon compound transport (GO:0019755)3.70104337
21notochord development (GO:0030903)3.69488202
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.67157227
23surfactant homeostasis (GO:0043129)3.60365668
24multicellular organismal water homeostasis (GO:0050891)3.57973804
25COPI coating of Golgi vesicle (GO:0048205)3.55225472
26Golgi transport vesicle coating (GO:0048200)3.55225472
27regulation of keratinocyte proliferation (GO:0010837)3.51750147
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.45320329
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44928372
30regulation of female receptivity (GO:0045924)3.44487118
31polarized epithelial cell differentiation (GO:0030859)3.44432580
32RNA localization (GO:0006403)3.43237227
33negative regulation of epidermis development (GO:0045683)3.42964847
34branching involved in salivary gland morphogenesis (GO:0060445)3.42650880
35phagocytosis, recognition (GO:0006910)3.41382173
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.41164513
37lung-associated mesenchyme development (GO:0060484)3.40711753
38camera-type eye morphogenesis (GO:0048593)3.40142636
39type B pancreatic cell proliferation (GO:0044342)3.39280767
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.38396881
41proline biosynthetic process (GO:0006561)3.36379452
42bone trabecula formation (GO:0060346)3.35539335
43face development (GO:0060324)3.35407513
44regulation of water loss via skin (GO:0033561)3.34672296
45hippo signaling (GO:0035329)3.33385248
46response to hepatocyte growth factor (GO:0035728)3.29798323
47cellular response to hepatocyte growth factor stimulus (GO:0035729)3.29798323
48regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.28616569
49renal filtration (GO:0097205)3.25371676
50vitamin transmembrane transport (GO:0035461)3.24012839
51lung epithelium development (GO:0060428)3.23401038
52glomerular basement membrane development (GO:0032836)3.22590872
53regulation of cholesterol homeostasis (GO:2000188)3.21538297
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.21307296
55primary alcohol catabolic process (GO:0034310)3.21177585
56ectoderm development (GO:0007398)3.20596519
57negative regulation of fatty acid transport (GO:2000192)3.17224016
58trophectodermal cell differentiation (GO:0001829)3.16729443
59negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.15870926
60intestinal epithelial cell development (GO:0060576)3.15352655
61endocardial cushion development (GO:0003197)3.13142436
62regulation of G0 to G1 transition (GO:0070316)3.13088134
63establishment of skin barrier (GO:0061436)3.12504788
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.11785071
65establishment of monopolar cell polarity (GO:0061162)3.11785071
66C21-steroid hormone biosynthetic process (GO:0006700)3.07247795
67regulation of cell fate specification (GO:0042659)3.06861501
68regulation of apoptotic process involved in morphogenesis (GO:1902337)3.06410028
69regulation of cholesterol biosynthetic process (GO:0045540)3.05813047
70C21-steroid hormone metabolic process (GO:0008207)3.03996900
71chemical homeostasis within a tissue (GO:0048875)3.02612704
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.02562272
73cytoskeletal anchoring at plasma membrane (GO:0007016)3.02445010
74establishment of epithelial cell polarity (GO:0090162)3.02181582
75mammary gland epithelial cell proliferation (GO:0033598)3.01971115
76cell-substrate junction assembly (GO:0007044)2.99224600
77regulation of keratinocyte differentiation (GO:0045616)2.99081406
78outer ear morphogenesis (GO:0042473)2.96886547
79bone morphogenesis (GO:0060349)2.96869573
80embryonic camera-type eye development (GO:0031076)2.96380380
81apical protein localization (GO:0045176)2.95733658
82atrioventricular valve morphogenesis (GO:0003181)2.92534813
83glomerular filtration (GO:0003094)2.91760486
84regulation of cardioblast differentiation (GO:0051890)2.91418560
85negative regulation of chondrocyte differentiation (GO:0032331)2.91215880
86biotin metabolic process (GO:0006768)2.90948582
87adherens junction assembly (GO:0034333)2.88749536
88ear development (GO:0043583)2.88646570
89hormone catabolic process (GO:0042447)2.86367863
90basement membrane organization (GO:0071711)2.86358272
91female mating behavior (GO:0060180)2.86282376
92establishment of tissue polarity (GO:0007164)2.85302813
93establishment of planar polarity (GO:0001736)2.85302813
94segment specification (GO:0007379)2.83951015
95interferon-gamma secretion (GO:0072643)2.83303543
96water homeostasis (GO:0030104)2.82424308
97regulation of bile acid biosynthetic process (GO:0070857)2.82355659
98negative regulation of cell fate commitment (GO:0010454)2.82322543
99endocardial cushion morphogenesis (GO:0003203)2.81138608
100endodermal cell differentiation (GO:0035987)2.80655927
101cellular response to epidermal growth factor stimulus (GO:0071364)2.79117753
102gas transport (GO:0015669)2.78652988
103cell proliferation involved in metanephros development (GO:0072203)2.77618482
104cell-cell junction assembly (GO:0007043)2.77571194
105somatic stem cell division (GO:0048103)2.77517873
106tight junction assembly (GO:0070830)2.77453967
107response to food (GO:0032094)2.76305211
108positive regulation of epidermis development (GO:0045684)2.76210506
109mesenchyme morphogenesis (GO:0072132)2.74103231
110cell migration involved in gastrulation (GO:0042074)2.74058430
111negative regulation of cell fate specification (GO:0009996)2.73882499
112collecting duct development (GO:0072044)2.73591248
113mesodermal cell differentiation (GO:0048333)2.73194774
114renal system development (GO:0072001)2.72460844
115convergent extension (GO:0060026)2.71427922
116excretion (GO:0007588)2.71334608
117cell adhesion mediated by integrin (GO:0033627)2.71119305
118amyloid precursor protein catabolic process (GO:0042987)2.70505569
119regulation of gene silencing by miRNA (GO:0060964)2.69928984
120regulation of gene silencing by RNA (GO:0060966)2.69928984
121regulation of posttranscriptional gene silencing (GO:0060147)2.69928984
122cell-substrate adherens junction assembly (GO:0007045)2.69148126
123focal adhesion assembly (GO:0048041)2.69148126
124eye morphogenesis (GO:0048592)2.68311439
125dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67456566
126hair follicle morphogenesis (GO:0031069)2.66804515
127embryonic process involved in female pregnancy (GO:0060136)2.66518738
128heart valve morphogenesis (GO:0003179)2.65659697
129negative regulation of cartilage development (GO:0061037)2.64928889
130cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64768155
131hypotonic response (GO:0006971)2.64172507
132Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63715127
133amyloid precursor protein metabolic process (GO:0042982)2.62846784
134maintenance of gastrointestinal epithelium (GO:0030277)2.61651346
135phosphate ion homeostasis (GO:0055062)2.61432942
136trivalent inorganic anion homeostasis (GO:0072506)2.61432942
137cell migration involved in sprouting angiogenesis (GO:0002042)2.61158434
138columnar/cuboidal epithelial cell development (GO:0002066)2.61128419
139skin morphogenesis (GO:0043589)2.59262743
140negative regulation of keratinocyte proliferation (GO:0010839)2.58361337
141positive regulation of extracellular matrix organization (GO:1903055)2.56968753
142calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.56301612
143iron ion import (GO:0097286)2.56236464
144non-canonical Wnt signaling pathway (GO:0035567)2.56055261
145labyrinthine layer blood vessel development (GO:0060716)2.55461399
146regulation of establishment of planar polarity (GO:0090175)2.54682002
147glomerular epithelial cell development (GO:0072310)2.54380578
148Notch signaling involved in heart development (GO:0061314)2.53476309
149protein retention in ER lumen (GO:0006621)2.53219877
150regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53100798
151negative regulation of potassium ion transmembrane transport (GO:1901380)2.52859322
152positive regulation of histone deacetylation (GO:0031065)2.51214868
153substrate adhesion-dependent cell spreading (GO:0034446)2.49793321
154positive regulation of protein import into nucleus, translocation (GO:0033160)2.49449393
155establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48769163
156establishment or maintenance of bipolar cell polarity (GO:0061245)2.48769163
157establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48292993
158nucleoside transmembrane transport (GO:1901642)2.47948402
159face morphogenesis (GO:0060325)2.47114559
160regulation of apoptotic cell clearance (GO:2000425)2.46839614
161negative regulation of epidermal cell differentiation (GO:0045605)2.45400772

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.36759652
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87535763
3ZNF263_19887448_ChIP-Seq_K562_Human3.76061544
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.45718194
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35594720
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.22458598
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.08017900
8HIF1A_21447827_ChIP-Seq_MCF-7_Human3.03991280
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.75216208
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38950954
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38950954
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38950954
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37193697
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.22248973
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14894755
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12798113
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.10765353
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99397981
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96668627
20ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.92674625
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91116785
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.90213952
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.85672694
24RACK7_27058665_Chip-Seq_MCF-7_Human1.84334494
25E2F7_22180533_ChIP-Seq_HELA_Human1.79541403
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.75650494
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75537665
28SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70846677
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.68529791
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68390700
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.67930860
32CLOCK_20551151_ChIP-Seq_293T_Human1.61442221
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58862415
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.58130066
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57976058
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.56725007
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55266214
38* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54961943
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54133993
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52262757
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51969411
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51320431
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51125343
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.51108386
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.50856353
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50380629
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.49501201
48ATF3_27146783_Chip-Seq_COLON_Human1.48296314
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47419727
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46958817
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.45692385
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44656736
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.43828386
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42744442
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42170858
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41018351
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.40836422
58KLF5_25053715_ChIP-Seq_YYC3_Human1.38301084
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37945293
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36705573
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36279338
62* SOX2_20726797_ChIP-Seq_SW620_Human1.36256938
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34565377
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.34125313
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.34125313
66AHR_22903824_ChIP-Seq_MCF-7_Human1.33773849
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33769915
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.32823980
69GATA6_25053715_ChIP-Seq_YYC3_Human1.32714986
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32646934
71TCF3_18692474_ChIP-Seq_MESCs_Mouse1.30712571
72LXR_22292898_ChIP-Seq_THP-1_Human1.23287057
73GATA4_25053715_ChIP-Seq_YYC3_Human1.22816079
74SMC4_20622854_ChIP-Seq_HELA_Human1.22707821
75TP53_20018659_ChIP-ChIP_R1E_Mouse1.22454191
76CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21465974
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.21238529
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21071325
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20031799
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.19984588
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19580296
82KDM2B_26808549_Chip-Seq_K562_Human1.18862540
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16655464
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16302531
85ELF5_23300383_ChIP-Seq_T47D_Human1.15220378
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14985753
87CJUN_26792858_Chip-Seq_BT549_Human1.11974943
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.11591881
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10676155
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.09531702
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.09421765
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.08976212
93TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08071545
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04896943
95* TP53_22127205_ChIP-Seq_IMR90_Human1.03666840
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02519993
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02501839
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.02370741
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01831285
100* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01646614
101AR_21909140_ChIP-Seq_LNCAP_Human1.01101650
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00747056
103CHD1_26751641_Chip-Seq_LNCaP_Human0.99166184
104SA1_27219007_Chip-Seq_ERYTHROID_Human0.98689710
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98671879
106* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98557270
107TCF7_22412390_ChIP-Seq_EML_Mouse0.98359734
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96378973
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96241787
110NANOG_18692474_ChIP-Seq_MEFs_Mouse0.96166910
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95172110
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94115880
113* TET1_21490601_ChIP-Seq_MESCs_Mouse0.94094283
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93864175
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.93755105
116* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93558531
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.93340524
118TBX20_22328084_ChIP-Seq_HEART_Mouse0.93340524
119TP63_22573176_ChIP-Seq_HFKS_Human0.92167859
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91581312
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.91028090
122* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91013076
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90758299
124PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90682040
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90639296
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.90049361
127CTCF_27219007_Chip-Seq_Bcells_Human0.89017330
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87004468
129CREB1_26743006_Chip-Seq_LNCaP_Human0.86641395
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85061246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.00658297
2MP0010234_abnormal_vibrissa_follicle4.16274667
3MP0003705_abnormal_hypodermis_morpholog3.66948724
4MP0005275_abnormal_skin_tensile2.70909702
5MP0004264_abnormal_extraembryonic_tissu2.69636309
6MP0002796_impaired_skin_barrier2.65513539
7MP0003566_abnormal_cell_adhesion2.63877557
8MP0004272_abnormal_basement_membrane2.60148433
9MP0008438_abnormal_cutaneous_collagen2.49004560
10MP0000566_synostosis2.21953449
11MP0010030_abnormal_orbit_morphology2.15722267
12MP0010352_gastrointestinal_tract_polyps2.15590783
13MP0000762_abnormal_tongue_morphology2.11226755
14MP0000537_abnormal_urethra_morphology2.08494624
15MP0001849_ear_inflammation2.08249655
16MP0005409_darkened_coat_color1.96889953
17MP0010678_abnormal_skin_adnexa1.94573775
18MP0009384_cardiac_valve_regurgitation1.92946730
19MP0009780_abnormal_chondrocyte_physiolo1.90089807
20MP0003941_abnormal_skin_development1.84202772
21MP0002098_abnormal_vibrissa_morphology1.80392814
22MP0002060_abnormal_skin_morphology1.77750945
23MP0003283_abnormal_digestive_organ1.75175946
24MP0000467_abnormal_esophagus_morphology1.72836962
25MP0003878_abnormal_ear_physiology1.69610331
26MP0005377_hearing/vestibular/ear_phenot1.69610331
27MP0005501_abnormal_skin_physiology1.67308834
28MP0003942_abnormal_urinary_system1.66252940
29MP0000383_abnormal_hair_follicle1.65481614
30MP0004782_abnormal_surfactant_physiolog1.62703171
31MP0009053_abnormal_anal_canal1.62457642
32MP0003453_abnormal_keratinocyte_physiol1.56270187
33MP0005023_abnormal_wound_healing1.55060697
34MP0005076_abnormal_cell_differentiation1.53984442
35MP0002089_abnormal_postnatal_growth/wei1.50723493
36MP0005623_abnormal_meninges_morphology1.46969490
37MP0000534_abnormal_ureter_morphology1.43139964
38MP0002282_abnormal_trachea_morphology1.41703416
39MP0005083_abnormal_biliary_tract1.40364505
40MP0004858_abnormal_nervous_system1.38242085
41MP0004019_abnormal_vitamin_homeostasis1.37525717
42MP0002653_abnormal_ependyma_morphology1.37153512
43MP0000579_abnormal_nail_morphology1.33155322
44MP0005508_abnormal_skeleton_morphology1.33055602
45MP0000377_abnormal_hair_follicle1.31706628
46MP0008875_abnormal_xenobiotic_pharmacok1.26140043
47MP0003300_gastrointestinal_ulcer1.25129571
48MP0002909_abnormal_adrenal_gland1.23982029
49MP0002249_abnormal_larynx_morphology1.22478585
50MP0005503_abnormal_tendon_morphology1.20783900
51MP0000428_abnormal_craniofacial_morphol1.20123213
52MP0001216_abnormal_epidermal_layer1.19919186
53MP0003122_maternal_imprinting1.17878843
54MP0002932_abnormal_joint_morphology1.17542549
55MP0001666_abnormal_nutrient_absorption1.14846920
56MP0005248_abnormal_Harderian_gland1.13691443
57MP0004885_abnormal_endolymph1.12983096
58MP0000462_abnormal_digestive_system1.12735023
59MP0003755_abnormal_palate_morphology1.11925123
60MP0006054_spinal_hemorrhage1.11348874
61MP0000049_abnormal_middle_ear1.08413152
62MP0003315_abnormal_perineum_morphology1.08175551
63MP0005360_urolithiasis1.07746718
64MP0000733_abnormal_muscle_development1.07490536
65MP0009672_abnormal_birth_weight1.06923280
66MP0002697_abnormal_eye_size1.06317176
67MP0002233_abnormal_nose_morphology1.06177620
68MP0000647_abnormal_sebaceous_gland1.05652441
69MP0002877_abnormal_melanocyte_morpholog1.05591749
70MP0003385_abnormal_body_wall1.05586627
71MP0002896_abnormal_bone_mineralization1.04761956
72MP0004381_abnormal_hair_follicle1.03605357
73MP0010771_integument_phenotype1.01836370
74MP0003937_abnormal_limbs/digits/tail_de1.01276364
75MP0000432_abnormal_head_morphology1.00965830
76* MP0004084_abnormal_cardiac_muscle1.00526160
77MP0001881_abnormal_mammary_gland1.00264187
78MP0003045_fibrosis0.99463645
79* MP0000750_abnormal_muscle_regeneration0.98311730
80MP0003115_abnormal_respiratory_system0.98014502
81MP0003191_abnormal_cellular_cholesterol0.96563597
82MP0002111_abnormal_tail_morphology0.95876866
83MP0003935_abnormal_craniofacial_develop0.95676957
84MP0003091_abnormal_cell_migration0.95395101
85MP0003693_abnormal_embryo_hatching0.94776326
86MP0003183_abnormal_peptide_metabolism0.94551143
87MP0000163_abnormal_cartilage_morphology0.94419682
88MP0005365_abnormal_bile_salt0.93832498
89MP0005451_abnormal_body_composition0.93644472
90MP0004197_abnormal_fetal_growth/weight/0.92302680
91MP0002234_abnormal_pharynx_morphology0.91719680
92MP0009250_abnormal_appendicular_skeleto0.91642137
93MP0009931_abnormal_skin_appearance0.89434484
94MP0002092_abnormal_eye_morphology0.89304027
95* MP0002925_abnormal_cardiovascular_devel0.87990675
96* MP0010630_abnormal_cardiac_muscle0.87623990
97MP0003567_abnormal_fetal_cardiomyocyte0.85381523
98MP0003943_abnormal_hepatobiliary_system0.85348652
99* MP0000627_abnormal_mammary_gland0.85266212
100MP0005408_hypopigmentation0.85136716
101MP0001958_emphysema0.84957196
102MP0004233_abnormal_muscle_weight0.83637330
103MP0005257_abnormal_intraocular_pressure0.83539275
104MP0003828_pulmonary_edema0.83180063
105MP0002088_abnormal_embryonic_growth/wei0.81468181
106MP0001340_abnormal_eyelid_morphology0.80895004
107MP0001243_abnormal_dermal_layer0.80778916
108MP0001299_abnormal_eye_distance/0.80164204
109MP0006138_congestive_heart_failure0.79528428
110MP0003938_abnormal_ear_development0.79283134
111MP0004957_abnormal_blastocyst_morpholog0.78779358
112MP0003984_embryonic_growth_retardation0.78466144
113MP0003279_aneurysm0.77024041
114MP0000427_abnormal_hair_cycle0.76899165
115MP0002086_abnormal_extraembryonic_tissu0.76684299
116MP0000767_abnormal_smooth_muscle0.76681875
117* MP0002116_abnormal_craniofacial_bone0.76643706
118MP0000678_abnormal_parathyroid_gland0.76554074
119MP0000003_abnormal_adipose_tissue0.76471036
120MP0002084_abnormal_developmental_patter0.75577085
121MP0005197_abnormal_uvea_morphology0.75161954
122MP0003119_abnormal_digestive_system0.75150526
123MP0001346_abnormal_lacrimal_gland0.74068503
124MP0001286_abnormal_eye_development0.73778894
125MP0002085_abnormal_embryonic_tissue0.73695415
126MP0001672_abnormal_embryogenesis/_devel0.73573478
127MP0005380_embryogenesis_phenotype0.73573478
128MP0000538_abnormal_urinary_bladder0.72940463
129MP0000613_abnormal_salivary_gland0.72023464
130MP0000470_abnormal_stomach_morphology0.71953490
131* MP0003936_abnormal_reproductive_system0.70552306
132* MP0000477_abnormal_intestine_morphology0.70248702
133MP0001730_embryonic_growth_arrest0.69948086
134MP0009840_abnormal_foam_cell0.67267624
135MP0000367_abnormal_coat/_hair0.66260209
136MP0001873_stomach_inflammation0.65459989
137MP0001765_abnormal_ion_homeostasis0.63785110

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.04240941
2Atrophic scars (HP:0001075)4.06849645
3Premature rupture of membranes (HP:0001788)3.94945386
4Abnormality of nail color (HP:0100643)3.93405693
5Shallow orbits (HP:0000586)3.80132677
6Protrusio acetabuli (HP:0003179)3.75028312
7Ankle contracture (HP:0006466)3.70488088
8Broad metatarsal (HP:0001783)3.57229957
9Milia (HP:0001056)3.53540893
10Abnormal hair laboratory examination (HP:0003328)3.21244750
11Mildly elevated creatine phosphokinase (HP:0008180)3.19501785
12Increased connective tissue (HP:0009025)3.11822050
13Sparse lateral eyebrow (HP:0005338)3.10737845
14Fragile skin (HP:0001030)2.93462786
15Bilateral microphthalmos (HP:0007633)2.82151523
16Concave nail (HP:0001598)2.79124115
17Amelogenesis imperfecta (HP:0000705)2.75748773
18Pili torti (HP:0003777)2.73854749
19Ventricular tachycardia (HP:0004756)2.69421037
20Hepatoblastoma (HP:0002884)2.68990857
21Abnormality of the distal phalanx of the thumb (HP:0009617)2.68805821
22Type 1 muscle fiber predominance (HP:0003803)2.66456864
23Hyperacusis (HP:0010780)2.63448443
24Fragile nails (HP:0001808)2.62775799
25Renal tubular acidosis (HP:0001947)2.61412301
26Lip pit (HP:0100267)2.58818850
27Hypoplasia of dental enamel (HP:0006297)2.58276309
28Neonatal short-limb short stature (HP:0008921)2.57464029
29Aortic dissection (HP:0002647)2.55133741
30Abnormality of the dental root (HP:0006486)2.53735909
31Taurodontia (HP:0000679)2.53735909
32Abnormality of permanent molar morphology (HP:0011071)2.53735909
33Onycholysis (HP:0001806)2.52843986
34Selective tooth agenesis (HP:0001592)2.49519818
35Woolly hair (HP:0002224)2.43040593
36Hydroxyprolinuria (HP:0003080)2.39179884
37Abnormality of proline metabolism (HP:0010907)2.39179884
38Abnormality of molar (HP:0011077)2.38705595
39Abnormality of molar morphology (HP:0011070)2.38705595
40Broad nasal tip (HP:0000455)2.34450445
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32156118
42Aortic aneurysm (HP:0004942)2.31831676
43Partial duplication of thumb phalanx (HP:0009944)2.31068015
44Pterygium (HP:0001059)2.30695931
45Cerebral aneurysm (HP:0004944)2.28609548
46Trismus (HP:0000211)2.28343346
47Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28140734
48Aplasia cutis congenita (HP:0001057)2.26452146
49Absent eyelashes (HP:0000561)2.25910083
50Alopecia of scalp (HP:0002293)2.25128996
51Hyperactive renin-angiotensin system (HP:0000841)2.23585337
52Abnormality of the distal phalanges of the toes (HP:0010182)2.22712531
53Abnormality of the dental pulp (HP:0006479)2.21432831
54Short nail (HP:0001799)2.20985176
55Thin bony cortex (HP:0002753)2.20326302
56Ankyloglossia (HP:0010296)2.20181108
57Chronic bronchitis (HP:0004469)2.20140751
58Arterial tortuosity (HP:0005116)2.18549757
59Turricephaly (HP:0000262)2.18395460
60Curly hair (HP:0002212)2.16870620
61Bronchomalacia (HP:0002780)2.14917105
62Flattened epiphyses (HP:0003071)2.14766172
63Tracheal stenosis (HP:0002777)2.13847931
64Mitral valve prolapse (HP:0001634)2.10503719
65Hyperglycinuria (HP:0003108)2.07773253
66Flat acetabular roof (HP:0003180)2.07760556
67Abnormality of the lacrimal duct (HP:0011481)2.07098007
68Coronal craniosynostosis (HP:0004440)2.05811307
69Blue sclerae (HP:0000592)2.05183840
70Follicular hyperkeratosis (HP:0007502)2.01330960
71Abnormality of the 4th metacarpal (HP:0010012)1.99100249
72Cervical subluxation (HP:0003308)1.98050609
73Peritonitis (HP:0002586)1.97831243
74Abnormality of the salivary glands (HP:0010286)1.96806048
75Absent epiphyses (HP:0010577)1.95877126
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95877126
77Abnormal cartilage morphology (HP:0002763)1.95663891
78Plantar hyperkeratosis (HP:0007556)1.95429049
79Exostoses (HP:0100777)1.94720600
80Anal stenosis (HP:0002025)1.94196720
81Severe Myopia (HP:0011003)1.93814159
82Septate vagina (HP:0001153)1.92669541
83Hypotrichosis (HP:0001006)1.92569608
84Broad face (HP:0000283)1.91642077
85Tarsal synostosis (HP:0008368)1.91480463
86Hip contracture (HP:0003273)1.90702364
87Abnormality of the proximal phalanges of the hand (HP:0009834)1.90571914
88Short hallux (HP:0010109)1.90549704
89Abnormality of monocarboxylic acid metabolism (HP:0010996)1.90132678
90Advanced eruption of teeth (HP:0006288)1.89655545
91Vertebral clefting (HP:0008428)1.88896889
92Aneurysm (HP:0002617)1.88522332
93Fused cervical vertebrae (HP:0002949)1.87850395
94Ulnar bowing (HP:0003031)1.87355534
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86122791
96Short 4th metacarpal (HP:0010044)1.86122791
97Distal lower limb amyotrophy (HP:0008944)1.85707060
98Vascular calcification (HP:0004934)1.85381824
99Vascular tortuosity (HP:0004948)1.85138932
100Nasolacrimal duct obstruction (HP:0000579)1.84952502
101Focal segmental glomerulosclerosis (HP:0000097)1.84812084
102Hypoplastic ischia (HP:0003175)1.84482778
103Mesangial abnormality (HP:0001966)1.84009055
104Deviation of the thumb (HP:0009603)1.82998347
105Abnormal tarsal ossification (HP:0008369)1.81983365
106Short middle phalanx of finger (HP:0005819)1.79818189
107Popliteal pterygium (HP:0009756)1.79726981
108Aplasia/Hypoplasia of the scapulae (HP:0006713)1.78620967
109Hypoplastic scapulae (HP:0000882)1.78620967
110Spinal rigidity (HP:0003306)1.78390278
111Sparse eyelashes (HP:0000653)1.77980923
112Urethral obstruction (HP:0000796)1.77975519
113Renal duplication (HP:0000075)1.77316615
114Abnormality of the middle phalanges of the toes (HP:0010183)1.77139912
115Multiple enchondromatosis (HP:0005701)1.76814921
116Abnormality of the nasolacrimal system (HP:0000614)1.76481299
117Aplasia involving bones of the upper limbs (HP:0009823)1.76452044
118Aplasia of the phalanges of the hand (HP:0009802)1.76452044
119Aplasia involving bones of the extremities (HP:0009825)1.76452044
120Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74941182
121Vertebral hypoplasia (HP:0008417)1.74941182
122Abnormality of the gastric mucosa (HP:0004295)1.74802301
123Down-sloping shoulders (HP:0200021)1.74446248
124Wide anterior fontanel (HP:0000260)1.73600262
125Dilatation of the ascending aorta (HP:0005111)1.73531821
126Abnormal vertebral ossification (HP:0100569)1.73299257
127Flat capital femoral epiphysis (HP:0003370)1.73181275
128Short humerus (HP:0005792)1.73112683
129Increased variability in muscle fiber diameter (HP:0003557)1.72589090
130Nail dystrophy (HP:0008404)1.71605253
131Esophageal atresia (HP:0002032)1.70735364
132Preaxial foot polydactyly (HP:0001841)1.70300356
133Bladder diverticulum (HP:0000015)1.70130723
134Hypoplastic labia majora (HP:0000059)1.69721250
135Broad toe (HP:0001837)1.68918995
136Tibial bowing (HP:0002982)1.68670132
137Aplasia/Hypoplasia of the hallux (HP:0008362)1.68440104
138Synostosis involving bones of the lower limbs (HP:0009138)1.68396436
139Synostosis involving bones of the feet (HP:0009140)1.68396436
140Abnormal blistering of the skin (HP:0008066)1.68394537
141Abnormality of oral frenula (HP:0000190)1.67725423
142Broad thumb (HP:0011304)1.67367037
143Exercise-induced muscle cramps (HP:0003710)1.67260112
144Lymphangioma (HP:0100764)1.66736209
145Partial duplication of the phalanx of hand (HP:0009999)1.66254051
146Rectal prolapse (HP:0002035)1.66001871
147Soft skin (HP:0000977)1.65451633
148Pseudobulbar signs (HP:0002200)1.65355046
149Skin pits (HP:0100276)1.64765642
150Hyperextensible skin (HP:0000974)1.64621212
151Blepharitis (HP:0000498)1.64202338
152Cardiovascular calcification (HP:0011915)1.62946154
153Ridged nail (HP:0001807)1.62870429
154Natal tooth (HP:0000695)1.62761357
155Abnormality of carpal bone ossification (HP:0006257)1.62622903
156Abdominal distention (HP:0003270)1.62339609
157Akinesia (HP:0002304)1.62254561
158Abnormality of the middle phalanges of the hand (HP:0009833)1.61862620
159Preauricular pit (HP:0004467)1.61860152
160Palmoplantar hyperkeratosis (HP:0000972)1.61519572
161Insidious onset (HP:0003587)1.60909453
162Termporal pattern (HP:0011008)1.60909453
163Arnold-Chiari malformation (HP:0002308)1.60556038
164Distal lower limb muscle weakness (HP:0009053)1.60277813
165Germ cell neoplasia (HP:0100728)1.59934067
166Overriding aorta (HP:0002623)1.59804823
167Smooth philtrum (HP:0000319)1.59636253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.77901055
2ERN13.42601858
3SIK13.33074035
4CDK123.31720728
5EPHB23.30747041
6NME22.50254476
7LATS12.44692898
8FER2.25049102
9WNK42.11256929
10SMG12.08411903
11TGFBR22.04692864
12TRIB32.03350512
13PKN21.99476957
14NTRK11.97131429
15RIPK11.84658711
16MST41.77009791
17TTN1.71298080
18PAK41.71046587
19PDGFRA1.70688679
20STK391.69490667
21BMX1.64674967
22DDR21.64117172
23STK101.59424012
24PTK21.54987348
25PTK61.52724637
26WNK11.50786686
27EPHB11.47919567
28MST1R1.39778857
29GRK61.38597815
30LATS21.38317953
31FGFR11.37316432
32EPHA31.35664731
33MAP3K101.34640733
34LMTK21.33345987
35MET1.33074230
36LRRK21.23217414
37RPS6KB21.17870181
38MAP3K21.14504145
39EEF2K1.09215564
40TYRO31.05734283
41* ERBB21.04635621
42GRK51.04508785
43MAP3K31.03263442
44STK38L1.01061739
45MAPK151.00062664
46MAP2K20.96932092
47* MATK0.95766184
48TTK0.95733755
49NME10.94686961
50BCR0.89740737
51MAP3K70.89470464
52PRKG20.86645342
53MAP3K60.84690733
54KSR10.84594713
55PAK30.83937841
56PIK3CA0.83902095
57FGFR30.82426855
58MTOR0.81728291
59MOS0.81066309
60CDC42BPA0.79950463
61TSSK60.78387884
62PAK20.78238998
63MAPKAPK30.78059394
64TESK10.76698287
65DMPK0.76561604
66STK30.75689320
67FGFR40.70379169
68PRKCI0.66980878
69MAP2K10.66123369
70DYRK1B0.65259654
71ERBB40.62534249
72TRPM70.61938386
73CAMK40.60719392
74NEK10.60161914
75RPS6KA20.59770770
76FGFR20.59286035
77CSF1R0.59279960
78NEK60.58793991
79PRKD30.57512506
80FRK0.55523690
81MYLK0.52736889
82MAP3K80.52332365
83MAPK70.52222968
84GRK10.51172094
85ICK0.50542675
86CDK70.49258623
87PBK0.48755727
88PDGFRB0.47223699
89CDK60.47045162
90ADRBK10.44345809
91MUSK0.44289181
92RET0.42375514
93EIF2AK10.42140425
94ALK0.42019113
95AKT20.41119857
96KSR20.40185041
97SIK30.40144946
98ILK0.39919786
99YES10.39790288
100ROCK10.39686820
101SRC0.37994786
102PRKD20.35621651
103CAMK1G0.35410645
104CAMK1D0.34533832
105CHUK0.33532052
106FLT30.33519678
107MAP3K90.32777109
108BCKDK0.32668044
109AURKB0.32163023
110MARK20.32109160
111STK240.31782995
112VRK20.31769734
113GSK3A0.30441910
114INSR0.29510088
115IGF1R0.28630738
116TAOK10.28354964
117MAPKAPK20.27916424
118ROCK20.27847963
119PRKD10.27456433
120PRKAA10.27246601
121STK380.26984755
122CSNK1E0.26594099
123CDK30.25907206
124CSNK1A10.25217256
125TAF10.24883137
126MAPK90.23228162
127CDK150.23083771
128CHEK10.23014833
129CAMK2D0.22561592
130MAPK80.22008565
131RPS6KL10.21838907
132RPS6KC10.21838907
133CDK10.21404962
134CDK180.21000040
135GSK3B0.19679695
136CAMK2G0.19623333
137RPS6KA10.19392710
138MAPK140.19056312
139CDK11A0.18395430
140BRSK10.17959673
141NEK20.17112461

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.27079779
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.64094744
3* Adherens junction_Homo sapiens_hsa045202.61031672
4Basal cell carcinoma_Homo sapiens_hsa052172.50880386
5Protein digestion and absorption_Homo sapiens_hsa049742.38287960
6Histidine metabolism_Homo sapiens_hsa003402.23560517
7Galactose metabolism_Homo sapiens_hsa000522.21017354
8Hippo signaling pathway_Homo sapiens_hsa043902.18764108
9* Focal adhesion_Homo sapiens_hsa045102.17698257
10Phenylalanine metabolism_Homo sapiens_hsa003602.17454604
11Vitamin digestion and absorption_Homo sapiens_hsa049772.13901827
12Tight junction_Homo sapiens_hsa045302.08997376
13* Bladder cancer_Homo sapiens_hsa052192.05883804
14* Proteoglycans in cancer_Homo sapiens_hsa052052.05480757
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86616120
16Small cell lung cancer_Homo sapiens_hsa052221.74524837
17Fructose and mannose metabolism_Homo sapiens_hsa000511.72284234
18Hedgehog signaling pathway_Homo sapiens_hsa043401.69001657
19Dilated cardiomyopathy_Homo sapiens_hsa054141.66858791
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.66785934
21Thyroid cancer_Homo sapiens_hsa052161.65597192
22Sulfur metabolism_Homo sapiens_hsa009201.65552444
23Arginine biosynthesis_Homo sapiens_hsa002201.64331289
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54958857
25Arginine and proline metabolism_Homo sapiens_hsa003301.54454822
26ABC transporters_Homo sapiens_hsa020101.53861072
27Sphingolipid metabolism_Homo sapiens_hsa006001.52715611
28Amoebiasis_Homo sapiens_hsa051461.50683355
29Tyrosine metabolism_Homo sapiens_hsa003501.49876862
30* Central carbon metabolism in cancer_Homo sapiens_hsa052301.49835093
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.48861083
32* MicroRNAs in cancer_Homo sapiens_hsa052061.46917397
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45779541
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34492311
35Collecting duct acid secretion_Homo sapiens_hsa049661.34483762
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25840217
37Notch signaling pathway_Homo sapiens_hsa043301.23730662
38Renal cell carcinoma_Homo sapiens_hsa052111.22750456
39* Pathways in cancer_Homo sapiens_hsa052001.21700119
40TGF-beta signaling pathway_Homo sapiens_hsa043501.21316550
41N-Glycan biosynthesis_Homo sapiens_hsa005101.20094970
42Other glycan degradation_Homo sapiens_hsa005111.19439442
43Vibrio cholerae infection_Homo sapiens_hsa051101.16812745
44Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13509020
45Renin-angiotensin system_Homo sapiens_hsa046141.12878804
46Chronic myeloid leukemia_Homo sapiens_hsa052201.11844945
47Axon guidance_Homo sapiens_hsa043601.10796384
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10076298
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08681183
50* HIF-1 signaling pathway_Homo sapiens_hsa040661.06935613
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06843014
52Mineral absorption_Homo sapiens_hsa049781.05588219
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02430723
54Wnt signaling pathway_Homo sapiens_hsa043101.01105394
55Thyroid hormone synthesis_Homo sapiens_hsa049180.98631090
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97677824
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96255516
58Fatty acid degradation_Homo sapiens_hsa000710.91422178
59Insulin signaling pathway_Homo sapiens_hsa049100.91236443
60Sulfur relay system_Homo sapiens_hsa041220.90468363
61Fat digestion and absorption_Homo sapiens_hsa049750.90350302
62Melanogenesis_Homo sapiens_hsa049160.86515687
63Rap1 signaling pathway_Homo sapiens_hsa040150.85956169
64Salivary secretion_Homo sapiens_hsa049700.85712418
65Lysine degradation_Homo sapiens_hsa003100.85581687
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84998805
67Fatty acid biosynthesis_Homo sapiens_hsa000610.84405779
68* Endometrial cancer_Homo sapiens_hsa052130.84091397
69beta-Alanine metabolism_Homo sapiens_hsa004100.83394872
70Retinol metabolism_Homo sapiens_hsa008300.82774571
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82433538
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.81712322
73Carbon metabolism_Homo sapiens_hsa012000.80377761
74Glucagon signaling pathway_Homo sapiens_hsa049220.80361239
75Fatty acid metabolism_Homo sapiens_hsa012120.79953454
76Insulin resistance_Homo sapiens_hsa049310.79910973
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.78231474
78mTOR signaling pathway_Homo sapiens_hsa041500.77158205
79* Pancreatic cancer_Homo sapiens_hsa052120.77048716
80Melanoma_Homo sapiens_hsa052180.76009782
81Toxoplasmosis_Homo sapiens_hsa051450.75586954
82PPAR signaling pathway_Homo sapiens_hsa033200.75516868
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74376004
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73965232
85Arachidonic acid metabolism_Homo sapiens_hsa005900.73744535
86Bile secretion_Homo sapiens_hsa049760.73138869
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.73003978
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72913709
89Estrogen signaling pathway_Homo sapiens_hsa049150.70793935
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70763777
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69445850
92VEGF signaling pathway_Homo sapiens_hsa043700.65525581
93Starch and sucrose metabolism_Homo sapiens_hsa005000.64719106
94* Prostate cancer_Homo sapiens_hsa052150.63759520
95Steroid biosynthesis_Homo sapiens_hsa001000.63517526
96Acute myeloid leukemia_Homo sapiens_hsa052210.62882066
97Viral myocarditis_Homo sapiens_hsa054160.62537130
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62433264
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62378103
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61876930
101Pyruvate metabolism_Homo sapiens_hsa006200.61589297
102Inositol phosphate metabolism_Homo sapiens_hsa005620.60997540
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.59556036
104Pentose phosphate pathway_Homo sapiens_hsa000300.59413434
105Glioma_Homo sapiens_hsa052140.59236738
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58631664
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58257874
108Chemical carcinogenesis_Homo sapiens_hsa052040.56828332
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56505801
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55509097
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53629572
112Choline metabolism in cancer_Homo sapiens_hsa052310.52992011
113Dorso-ventral axis formation_Homo sapiens_hsa043200.52756199
114* Non-small cell lung cancer_Homo sapiens_hsa052230.52644909
115HTLV-I infection_Homo sapiens_hsa051660.51934159
116Caffeine metabolism_Homo sapiens_hsa002320.50038082
117AMPK signaling pathway_Homo sapiens_hsa041520.49597209
118Biosynthesis of amino acids_Homo sapiens_hsa012300.49528642
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48894528
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48778299
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48573447
122Glutathione metabolism_Homo sapiens_hsa004800.48373576
123Colorectal cancer_Homo sapiens_hsa052100.47738507
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47430431
125Tryptophan metabolism_Homo sapiens_hsa003800.46486951
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.46405672
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46228910
128Pancreatic secretion_Homo sapiens_hsa049720.46124276
129mRNA surveillance pathway_Homo sapiens_hsa030150.45853322
130Vitamin B6 metabolism_Homo sapiens_hsa007500.43856029
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40804944
132* ErbB signaling pathway_Homo sapiens_hsa040120.38468407

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