ERBB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.74861778
2L-phenylalanine catabolic process (GO:0006559)6.74861778
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.36579456
4L-phenylalanine metabolic process (GO:0006558)6.36579456
5aromatic amino acid family catabolic process (GO:0009074)5.72301495
6sulfur amino acid catabolic process (GO:0000098)5.19598293
7cysteine metabolic process (GO:0006534)5.17651563
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.17312783
9bile acid biosynthetic process (GO:0006699)5.05912418
10desmosome organization (GO:0002934)4.96029003
11indole-containing compound catabolic process (GO:0042436)4.90170998
12indolalkylamine catabolic process (GO:0046218)4.90170998
13tryptophan catabolic process (GO:0006569)4.90170998
14alpha-linolenic acid metabolic process (GO:0036109)4.88319998
15glyoxylate metabolic process (GO:0046487)4.88201019
16kynurenine metabolic process (GO:0070189)4.83361874
17urea cycle (GO:0000050)4.77131593
18urea metabolic process (GO:0019627)4.77131593
19tryptophan metabolic process (GO:0006568)4.61151881
20bile acid metabolic process (GO:0008206)4.60260551
21high-density lipoprotein particle remodeling (GO:0034375)4.53640968
22intestinal cholesterol absorption (GO:0030299)4.43674344
23homocysteine metabolic process (GO:0050667)4.41376768
24nitrogen cycle metabolic process (GO:0071941)4.38841945
25regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.38027498
26regulation of triglyceride catabolic process (GO:0010896)4.31974713
27protein carboxylation (GO:0018214)4.26641506
28peptidyl-glutamic acid carboxylation (GO:0017187)4.26641506
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.26167970
30bile acid and bile salt transport (GO:0015721)4.25929333
31complement activation, alternative pathway (GO:0006957)4.25869504
32regulation of bile acid biosynthetic process (GO:0070857)4.25270854
33negative regulation of fibrinolysis (GO:0051918)4.24296273
34cellular glucuronidation (GO:0052695)4.24032064
35regulation of protein activation cascade (GO:2000257)4.22534809
36epoxygenase P450 pathway (GO:0019373)4.21340020
37fatty acid elongation (GO:0030497)4.20741573
38vitamin transmembrane transport (GO:0035461)4.18785521
39aromatic amino acid family metabolic process (GO:0009072)4.14513528
40serine family amino acid catabolic process (GO:0009071)4.13733693
41negative regulation of sterol transport (GO:0032372)4.13700698
42negative regulation of cholesterol transport (GO:0032375)4.13700698
43regulation of fibrinolysis (GO:0051917)4.12818680
44drug catabolic process (GO:0042737)4.07841683
45regulation of cholesterol esterification (GO:0010872)4.07024659
46tyrosine metabolic process (GO:0006570)4.04011641
47bundle of His cell to Purkinje myocyte communication (GO:0086069)4.03617448
48ethanol oxidation (GO:0006069)4.03512831
49reverse cholesterol transport (GO:0043691)3.99523716
50regulation of complement activation (GO:0030449)3.94216560
51phospholipid efflux (GO:0033700)3.94133652
52amino-acid betaine metabolic process (GO:0006577)3.93554202
53cholesterol efflux (GO:0033344)3.93436087
54heme transport (GO:0015886)3.91732713
55triglyceride homeostasis (GO:0070328)3.90568662
56acylglycerol homeostasis (GO:0055090)3.90568662
57regulation of cholesterol homeostasis (GO:2000188)3.87419096
58low-density lipoprotein particle remodeling (GO:0034374)3.86680572
59protein-lipid complex remodeling (GO:0034368)3.86657680
60macromolecular complex remodeling (GO:0034367)3.86657680
61plasma lipoprotein particle remodeling (GO:0034369)3.86657680
62plasma lipoprotein particle clearance (GO:0034381)3.86453718
63glucuronate metabolic process (GO:0019585)3.85098489
64uronic acid metabolic process (GO:0006063)3.85098489
65cholesterol homeostasis (GO:0042632)3.81985535
66lysine catabolic process (GO:0006554)3.81505054
67lysine metabolic process (GO:0006553)3.81505054
68very long-chain fatty acid metabolic process (GO:0000038)3.81061490
69alpha-amino acid catabolic process (GO:1901606)3.80670339
70intestinal absorption (GO:0050892)3.76391924
71intestinal epithelial cell development (GO:0060576)3.76236266
72sterol homeostasis (GO:0055092)3.75900638
73coenzyme catabolic process (GO:0009109)3.75072922
74positive regulation of lipoprotein lipase activity (GO:0051006)3.72541464
75positive regulation of triglyceride lipase activity (GO:0061365)3.72541464
76response to nitrosative stress (GO:0051409)3.72285047
77cellular ketone body metabolic process (GO:0046950)3.72255822
78very-low-density lipoprotein particle assembly (GO:0034379)3.70899553
79serine family amino acid metabolic process (GO:0009069)3.67602178
80glutamate metabolic process (GO:0006536)3.66970184
81proline metabolic process (GO:0006560)3.65589956
82acetyl-CoA metabolic process (GO:0006084)3.65318484
83cellular modified amino acid catabolic process (GO:0042219)3.63988539
84cellular amino acid catabolic process (GO:0009063)3.63536245
85flavonoid metabolic process (GO:0009812)3.63288706
86serine family amino acid biosynthetic process (GO:0009070)3.62974559
87short-chain fatty acid metabolic process (GO:0046459)3.60750178
88plasma lipoprotein particle assembly (GO:0034377)3.59565919
89drug transmembrane transport (GO:0006855)3.59364200
90multicellular organismal water homeostasis (GO:0050891)3.53072055
91benzene-containing compound metabolic process (GO:0042537)3.48878417
92regulation of cholesterol biosynthetic process (GO:0045540)3.48739730
93lung epithelium development (GO:0060428)3.47641465
94proline biosynthetic process (GO:0006561)3.47607861
95regulation of water loss via skin (GO:0033561)3.47277945
96ethanol metabolic process (GO:0006067)3.46979384
97trivalent inorganic anion homeostasis (GO:0072506)3.46687062
98phosphate ion homeostasis (GO:0055062)3.46687062
99amine catabolic process (GO:0009310)3.45893731
100cellular biogenic amine catabolic process (GO:0042402)3.45893731
101negative regulation of lipase activity (GO:0060192)3.45774146
102plasma lipoprotein particle organization (GO:0071827)3.44396429
103glycine metabolic process (GO:0006544)3.43568375
104drug metabolic process (GO:0017144)3.43037059
105protein-lipid complex assembly (GO:0065005)3.42669688
106indolalkylamine metabolic process (GO:0006586)3.41935813
107exogenous drug catabolic process (GO:0042738)3.39474796
108positive regulation of fatty acid beta-oxidation (GO:0032000)3.39469440
109fibrinolysis (GO:0042730)3.39324282
110phospholipid homeostasis (GO:0055091)3.36792379
111diacylglycerol metabolic process (GO:0046339)3.36241052
112cholesterol biosynthetic process (GO:0006695)3.35999080
113regulation of cholesterol metabolic process (GO:0090181)3.34278062
114lipoprotein metabolic process (GO:0042157)3.32055250
115regulation of apoptotic cell clearance (GO:2000425)3.30551724
116ketone body metabolic process (GO:1902224)3.28341239
117fatty-acyl-CoA biosynthetic process (GO:0046949)3.27236595
118organic acid catabolic process (GO:0016054)3.25826954
119carboxylic acid catabolic process (GO:0046395)3.25826954
120angiotensin maturation (GO:0002003)3.25337342
121renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.23753409
122protein-lipid complex subunit organization (GO:0071825)3.22949744
123primary alcohol catabolic process (GO:0034310)3.12594962
124embryonic retina morphogenesis in camera-type eye (GO:0060059)3.11787321
125calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.09762333
126positive regulation of lipid catabolic process (GO:0050996)3.06574407
127sodium ion homeostasis (GO:0055078)3.03901133
128regulation of fatty acid beta-oxidation (GO:0031998)3.00144294
129positive regulation of cellular amine metabolic process (GO:0033240)2.99565226
130water homeostasis (GO:0030104)2.99222592
131establishment of skin barrier (GO:0061436)2.98795503
132glutamine family amino acid biosynthetic process (GO:0009084)2.98423620
133maintenance of gastrointestinal epithelium (GO:0030277)2.93551454
134blood coagulation, intrinsic pathway (GO:0007597)2.88605833
135negative regulation of fatty acid transport (GO:2000192)2.88472689
136negative regulation of protein activation cascade (GO:2000258)2.88465798
137regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.88134721
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.83085416
139complement activation, classical pathway (GO:0006958)2.80051008
140NADH metabolic process (GO:0006734)2.77777560
141fat-soluble vitamin biosynthetic process (GO:0042362)2.75370534
142transepithelial transport (GO:0070633)2.73278715
143negative regulation of sodium ion transport (GO:0010766)2.72785379
144cellular anion homeostasis (GO:0030002)2.72737809
145biotin metabolic process (GO:0006768)2.71214239
146lipoprotein transport (GO:0042953)2.68324623
147modified amino acid transport (GO:0072337)2.66347982
148endocrine process (GO:0050886)2.64213724

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.12386763
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.53123645
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.68144431
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.43505571
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.16691352
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08242299
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.60340285
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.49777812
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.49340352
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.44403339
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.90640557
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.78463048
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56507630
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.22378162
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.05322616
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85434896
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81435729
18HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78876960
19* FOXA2_19822575_ChIP-Seq_HepG2_Human1.77598219
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.72442563
21GATA4_25053715_ChIP-Seq_YYC3_Human1.66773025
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60115144
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.56238117
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56186282
25LXR_22292898_ChIP-Seq_THP-1_Human1.55625514
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.52226255
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49210371
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46092943
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.45865170
30ZNF263_19887448_ChIP-Seq_K562_Human1.45500363
31* CLOCK_20551151_ChIP-Seq_293T_Human1.44889053
32AR_21909140_ChIP-Seq_LNCAP_Human1.38956296
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37261537
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35066619
35SOX2_20726797_ChIP-Seq_SW620_Human1.33943914
36* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33622813
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.32740908
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29537572
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28255626
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.25474705
41GATA6_25053715_ChIP-Seq_YYC3_Human1.24292662
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24143491
43GATA1_22025678_ChIP-Seq_K562_Human1.21386202
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20182807
45HTT_18923047_ChIP-ChIP_STHdh_Human1.19661942
46FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17027479
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16879086
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16517610
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16423343
50CREB1_26743006_Chip-Seq_LNCaP_Human1.16228625
51* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16165775
52DROSHA_22980978_ChIP-Seq_HELA_Human1.13921146
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12530633
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10689409
55SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10678608
56CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10156772
57SMC4_20622854_ChIP-Seq_HELA_Human1.07459328
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05410957
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03822747
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02803674
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00727619
62FOXA1_25552417_ChIP-Seq_VCAP_Human0.99695370
63* KDM2B_26808549_Chip-Seq_K562_Human0.98625191
64SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97431369
65CTCF_27219007_Chip-Seq_Bcells_Human0.97210102
66NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96412193
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96412193
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96275089
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95889285
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94753159
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94529739
72* TP63_22573176_ChIP-Seq_HFKS_Human0.94165076
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93146632
74RACK7_27058665_Chip-Seq_MCF-7_Human0.92684734
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92426585
76* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91958311
77* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90513236
78DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90512798
79P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89410641
80TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88542319
81* TRIM28_21343339_ChIP-Seq_HEK293_Human0.87570337
82* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87048283
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85079317
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83443536
85GATA3_24758297_ChIP-Seq_MCF-7_Human0.83383826
86* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81584903
87MYC_27129775_Chip-Seq_CORNEA_Mouse0.79753857
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79371219
89AHR_22903824_ChIP-Seq_MCF-7_Human0.78961037
90P68_20966046_ChIP-Seq_HELA_Human0.77415802
91KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77223443
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.77065374
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76684845
94* ATF3_27146783_Chip-Seq_COLON_Human0.76274336
95TET1_21451524_ChIP-Seq_MESCs_Mouse0.76209778
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75419152
97RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75418212
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75011486
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.74981426
100ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74588220
101TP63_23658742_ChIP-Seq_EP156T_Human0.74484108
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73656404
103JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73610180
104STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.73474528
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73433012
106* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73021914
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70819282
108* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.69763109
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69476107
110CEBPB_22108803_ChIP-Seq_LS180_Human0.68731381
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68354533
112FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67904319
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67763142
114* RUNX1_27514584_Chip-Seq_MCF-7_Human0.67743850
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.65957754
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65710573
117STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.65133496
118KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.65044777
119KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.65044777
120KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.65044777
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.64415763
122CDX2_22108803_ChIP-Seq_LS180_Human0.64191664
123EGR1_19032775_ChIP-ChIP_M12_Human0.63988353
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63815449
125GATA2_19941826_ChIP-Seq_K562_Human0.63610442
126GATA1_19941826_ChIP-Seq_K562_Human0.63071061
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.60419535
128CBP_21632823_ChIP-Seq_H3396_Human0.59424264
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59030672
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.58632085
131KLF5_25053715_ChIP-Seq_YYC3_Human0.58298674
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.57795414
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57736696
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57521331
135SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56630742
136CJUN_26792858_Chip-Seq_BT549_Human0.56390581
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.55855209
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.55855209

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.25026962
2MP0002139_abnormal_hepatobiliary_system6.98718885
3MP0005085_abnormal_gallbladder_physiolo5.74801191
4MP0005365_abnormal_bile_salt5.22975426
5MP0008875_abnormal_xenobiotic_pharmacok4.88231774
6MP0003806_abnormal_nucleotide_metabolis3.99319670
7MP0003252_abnormal_bile_duct3.65676431
8MP0001666_abnormal_nutrient_absorption3.35864121
9MP0009840_abnormal_foam_cell3.10643348
10MP0010329_abnormal_lipoprotein_level3.00589044
11MP0009780_abnormal_chondrocyte_physiolo2.96418933
12MP0005083_abnormal_biliary_tract2.58798509
13MP0005332_abnormal_amino_acid2.49345611
14MP0010234_abnormal_vibrissa_follicle2.42106178
15MP0005409_darkened_coat_color2.39696851
16MP0003195_calcinosis2.29629503
17MP0003183_abnormal_peptide_metabolism2.18773085
18MP0004019_abnormal_vitamin_homeostasis2.10766801
19MP0003191_abnormal_cellular_cholesterol2.07819439
20MP0002118_abnormal_lipid_homeostasis1.93980485
21MP0003123_paternal_imprinting1.92476390
22MP0005451_abnormal_body_composition1.91379101
23MP0002089_abnormal_postnatal_growth/wei1.85828813
24MP0002796_impaired_skin_barrier1.83464963
25MP0000609_abnormal_liver_physiology1.77638684
26MP0002254_reproductive_system_inflammat1.72454733
27MP0005171_absent_coat_pigmentation1.72206487
28MP0010678_abnormal_skin_adnexa1.61702415
29MP0004264_abnormal_extraembryonic_tissu1.59121216
30MP0003941_abnormal_skin_development1.57465490
31MP0003868_abnormal_feces_composition1.57040387
32MP0002138_abnormal_hepatobiliary_system1.49016364
33MP0004381_abnormal_hair_follicle1.46357891
34MP0003705_abnormal_hypodermis_morpholog1.43872271
35MP0003122_maternal_imprinting1.43283408
36MP0000678_abnormal_parathyroid_gland1.42131352
37MP0000462_abnormal_digestive_system1.38186224
38MP0005319_abnormal_enzyme/_coenzyme1.37913112
39MP0001664_abnormal_digestion1.37788022
40MP0002876_abnormal_thyroid_physiology1.35650648
41MP0000920_abnormal_myelination1.34470202
42MP0009643_abnormal_urine_homeostasis1.33121976
43MP0005257_abnormal_intraocular_pressure1.30020452
44MP0002249_abnormal_larynx_morphology1.27190028
45MP0003136_yellow_coat_color1.26719859
46MP0000383_abnormal_hair_follicle1.24490658
47MP0000579_abnormal_nail_morphology1.24083966
48MP0003011_delayed_dark_adaptation1.23057835
49MP0005584_abnormal_enzyme/coenzyme_acti1.21750259
50MP0003879_abnormal_hair_cell1.21707208
51MP0009379_abnormal_foot_pigmentation1.19958867
52MP0005670_abnormal_white_adipose1.19195009
53MP0002909_abnormal_adrenal_gland1.09653638
54MP0003690_abnormal_glial_cell1.09588607
55MP0003453_abnormal_keratinocyte_physiol1.06860541
56MP0003950_abnormal_plasma_membrane1.05853179
57MP0004858_abnormal_nervous_system1.05847757
58MP0005076_abnormal_cell_differentiation1.04510659
59MP0002098_abnormal_vibrissa_morphology1.03104816
60MP0000566_synostosis1.00626404
61MP0000467_abnormal_esophagus_morphology1.00151386
62MP0000604_amyloidosis0.99616184
63MP0003638_abnormal_response/metabolism_0.99080909
64MP0003329_amyloid_beta_deposits0.98647493
65MP0001764_abnormal_homeostasis0.97866048
66* MP0000627_abnormal_mammary_gland0.96311093
67MP0000377_abnormal_hair_follicle0.93052492
68MP0000534_abnormal_ureter_morphology0.91975202
69MP0005501_abnormal_skin_physiology0.91413275
70MP0003866_abnormal_defecation0.89918502
71MP0004043_abnormal_pH_regulation0.89502276
72MP0000647_abnormal_sebaceous_gland0.86649274
73MP0005636_abnormal_mineral_homeostasis0.86447138
74MP0002060_abnormal_skin_morphology0.85990371
75MP0005647_abnormal_sex_gland0.84848738
76MP0001661_extended_life_span0.81874762
77MP0000537_abnormal_urethra_morphology0.81761530
78MP0000371_diluted_coat_color0.81651023
79MP0000598_abnormal_liver_morphology0.81641875
80MP0003186_abnormal_redox_activity0.81239390
81MP0009053_abnormal_anal_canal0.79743706
82MP0003656_abnormal_erythrocyte_physiolo0.78831588
83MP0002938_white_spotting0.78068396
84MP0005646_abnormal_pituitary_gland0.76558473
85MP0002896_abnormal_bone_mineralization0.75173251
86MP0001216_abnormal_epidermal_layer0.75068219
87MP0010352_gastrointestinal_tract_polyps0.74383296
88MP0009765_abnormal_xenobiotic_induced0.74308423
89MP0004885_abnormal_endolymph0.73864713
90MP0001873_stomach_inflammation0.72545578
91MP0004272_abnormal_basement_membrane0.72167056
92MP0009697_abnormal_copulation0.72099917
93MP0003566_abnormal_cell_adhesion0.71574157
94MP0000427_abnormal_hair_cycle0.71236193
95MP0001756_abnormal_urination0.69310496
96MP0005248_abnormal_Harderian_gland0.68850741
97MP0004147_increased_porphyrin_level0.68423841
98MP0003115_abnormal_respiratory_system0.68418791
99MP0005075_abnormal_melanosome_morpholog0.68413625
100* MP0005408_hypopigmentation0.67399034
101MP0001485_abnormal_pinna_reflex0.67350120
102MP0003942_abnormal_urinary_system0.66792396
103MP0002132_abnormal_respiratory_system0.66627078
104MP0002160_abnormal_reproductive_system0.64954807
105MP0001346_abnormal_lacrimal_gland0.64828071
106MP0005275_abnormal_skin_tensile0.63708016
107MP0000367_abnormal_coat/_hair0.63320258
108MP0009763_increased_sensitivity_to0.63154131
109MP0000762_abnormal_tongue_morphology0.61075303
110MP0009764_decreased_sensitivity_to0.59598476
111* MP0009642_abnormal_blood_homeostasis0.57847660
112MP0003315_abnormal_perineum_morphology0.57044196
113MP0002075_abnormal_coat/hair_pigmentati0.56861303
114MP0003300_gastrointestinal_ulcer0.56537857
115MP0002971_abnormal_brown_adipose0.56495135
116MP0005376_homeostasis/metabolism_phenot0.56285788
117MP0004185_abnormal_adipocyte_glucose0.55628122
118MP0003718_maternal_effect0.54534554
119MP0002136_abnormal_kidney_physiology0.54071480
120MP0010771_integument_phenotype0.53584701
121MP0004782_abnormal_surfactant_physiolog0.53236012
122MP0005395_other_phenotype0.51743382
123MP0005266_abnormal_metabolism0.51667712
124MP0001243_abnormal_dermal_layer0.51326903
125MP0001881_abnormal_mammary_gland0.50241555
126MP0001849_ear_inflammation0.49954789
127MP0005220_abnormal_exocrine_pancreas0.49285123
128MP0000538_abnormal_urinary_bladder0.48626139
129MP0005381_digestive/alimentary_phenotyp0.47733826
130MP0001765_abnormal_ion_homeostasis0.47653291
131MP0005666_abnormal_adipose_tissue0.47010898
132MP0005084_abnormal_gallbladder_morpholo0.44883528
133MP0008469_abnormal_protein_level0.44877941
134MP0004947_skin_inflammation0.44464367
135MP0005334_abnormal_fat_pad0.41707106
136MP0000477_abnormal_intestine_morphology0.41540240
137MP0000613_abnormal_salivary_gland0.39555734
138MP0005058_abnormal_lysosome_morphology0.39480543
139MP0005377_hearing/vestibular/ear_phenot0.38817910
140MP0003878_abnormal_ear_physiology0.38817910

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.34815172
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.11621995
3Deep venous thrombosis (HP:0002625)6.09848438
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.04187722
5Xanthomatosis (HP:0000991)5.76084806
6Hypobetalipoproteinemia (HP:0003563)5.73249349
7Prolonged partial thromboplastin time (HP:0003645)5.09645547
8Hyperlipoproteinemia (HP:0010980)4.54591967
9Fat malabsorption (HP:0002630)4.43999134
10Flat acetabular roof (HP:0003180)4.43357514
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.27424718
12Complement deficiency (HP:0004431)4.17489882
13Hypolipoproteinemia (HP:0010981)4.16555342
14Epidermoid cyst (HP:0200040)4.15982767
15Hyperammonemia (HP:0001987)3.97130616
16Conjugated hyperbilirubinemia (HP:0002908)3.93978675
17Abnormality of glycine metabolism (HP:0010895)3.91525875
18Abnormality of serine family amino acid metabolism (HP:0010894)3.91525875
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.91130093
20Hyperglycinuria (HP:0003108)3.86709841
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.85608370
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.84103453
23Hyperglycinemia (HP:0002154)3.79748349
24Abnormality of methionine metabolism (HP:0010901)3.52966616
25Abnormality of the common coagulation pathway (HP:0010990)3.49148521
26Glomerulonephritis (HP:0000099)3.48403773
27Ketosis (HP:0001946)3.43134016
28Hypoalphalipoproteinemia (HP:0003233)3.39450424
29Ileus (HP:0002595)3.24466444
30Joint hemorrhage (HP:0005261)3.21434227
31Steatorrhea (HP:0002570)3.20823916
32Malnutrition (HP:0004395)3.20786829
33Hypercholesterolemia (HP:0003124)3.14217224
34Hyperactive renin-angiotensin system (HP:0000841)3.07691942
35Abnormality of complement system (HP:0005339)2.99912248
36Abnormality of the nasal septum (HP:0000419)2.99406667
37Acanthocytosis (HP:0001927)2.95689771
38Vascular calcification (HP:0004934)2.94212396
39Hypoglycemic coma (HP:0001325)2.93538340
40Abnormality of the intrinsic pathway (HP:0010989)2.91917607
41Abnormality of fatty-acid metabolism (HP:0004359)2.87524167
42Systemic lupus erythematosus (HP:0002725)2.86506409
43Abnormality of carpal bone ossification (HP:0006257)2.79830935
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75839864
45Asymmetry of the thorax (HP:0001555)2.74267001
46Hyperbilirubinemia (HP:0002904)2.72974291
47Right ventricular cardiomyopathy (HP:0011663)2.69135498
48Widely patent fontanelles and sutures (HP:0004492)2.66390963
49Cardiovascular calcification (HP:0011915)2.59787238
50Pili torti (HP:0003777)2.59668778
51Pigmentary retinal degeneration (HP:0001146)2.57954410
52Abnormality of purine metabolism (HP:0004352)2.56054874
53Abnormality of nucleobase metabolism (HP:0010932)2.54985217
54Abnormality of pyrimidine metabolism (HP:0004353)2.52845901
55Gout (HP:0001997)2.52520868
56Thin bony cortex (HP:0002753)2.50236997
57Rickets (HP:0002748)2.46400896
58Hepatocellular carcinoma (HP:0001402)2.44262312
59Metabolic acidosis (HP:0001942)2.42266018
60Delayed CNS myelination (HP:0002188)2.38766330
61Parakeratosis (HP:0001036)2.38431662
62Spastic paraparesis (HP:0002313)2.36699697
63Ketoacidosis (HP:0001993)2.36377896
64Alacrima (HP:0000522)2.35298352
65Neurofibrillary tangles (HP:0002185)2.33642715
66J-shaped sella turcica (HP:0002680)2.33076604
67Skin nodule (HP:0200036)2.32943285
68Abnormality of serum amino acid levels (HP:0003112)2.32241729
69Myocardial infarction (HP:0001658)2.31660384
70Germ cell neoplasia (HP:0100728)2.31474939
71Hypophosphatemic rickets (HP:0004912)2.29352390
72Hypochromic microcytic anemia (HP:0004840)2.27039392
73Abnormality of vitamin metabolism (HP:0100508)2.25256944
74Spontaneous abortion (HP:0005268)2.23696847
75Dicarboxylic aciduria (HP:0003215)2.23528148
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23528148
77Lip pit (HP:0100267)2.22841841
78Osteomalacia (HP:0002749)2.21977766
79Spastic diplegia (HP:0001264)2.21710426
80Abnormal hand bone ossification (HP:0010660)2.21166885
81Abnormal hair laboratory examination (HP:0003328)2.20511305
82Amyloidosis (HP:0011034)2.20470042
83Lethargy (HP:0001254)2.18807060
84Abnormal gallbladder morphology (HP:0012437)2.18689442
85Esophageal varix (HP:0002040)2.15203129
86Abnormality of the gastric mucosa (HP:0004295)2.14494360
87Bronchomalacia (HP:0002780)2.13666749
88Facial shape deformation (HP:0011334)2.13664809
89Potter facies (HP:0002009)2.13664809
90Abnormality of proline metabolism (HP:0010907)2.12750251
91Hydroxyprolinuria (HP:0003080)2.12750251
92Nephritis (HP:0000123)2.09364439
93Abnormal ossification of hand bones (HP:0005921)2.07626219
94Irritability (HP:0000737)2.07515900
95Epiphyseal dysplasia (HP:0002656)2.06390068
96Abnormal gallbladder physiology (HP:0012438)2.05909003
97Cholecystitis (HP:0001082)2.05909003
98Alkalosis (HP:0001948)2.05107173
99Wide cranial sutures (HP:0010537)2.03296376
100Cholelithiasis (HP:0001081)2.02196534
101Hemorrhage of the eye (HP:0011885)1.99523427
102Abdominal distention (HP:0003270)1.98363077
103Decreased circulating renin level (HP:0003351)1.97639508
104Blue irides (HP:0000635)1.95800984
105Abnormality of chloride homeostasis (HP:0011422)1.95643917
106Abnormality of renin-angiotensin system (HP:0000847)1.93744686
107Hypotension (HP:0002615)1.93460587
108Congenital ichthyosiform erythroderma (HP:0007431)1.92618796
109Glycosuria (HP:0003076)1.92490596
110Abnormality of urine glucose concentration (HP:0011016)1.92490596
111Pancreatitis (HP:0001733)1.91847717
112Proximal tubulopathy (HP:0000114)1.90909898
113Abnormal enzyme/coenzyme activity (HP:0012379)1.90713414
114Menorrhagia (HP:0000132)1.90147246
115Peripheral demyelination (HP:0011096)1.88962459
116Curly hair (HP:0002212)1.88853634
117Hyperkalemia (HP:0002153)1.88491435
118Glomerulosclerosis (HP:0000096)1.87421607
119Protuberant abdomen (HP:0001538)1.87058537
120Cerebral inclusion bodies (HP:0100314)1.85482364
121Popliteal pterygium (HP:0009756)1.85201750
122Septate vagina (HP:0001153)1.84736269
123Hypophosphatemia (HP:0002148)1.84252261
124Abnormal cartilage morphology (HP:0002763)1.83660875
125Enlarged epiphyses (HP:0010580)1.83598807
126Concave nail (HP:0001598)1.83331430
127Focal segmental glomerulosclerosis (HP:0000097)1.82514686
128Sensory axonal neuropathy (HP:0003390)1.81318481
129Abnormal tarsal ossification (HP:0008369)1.80844576
130Bifid scrotum (HP:0000048)1.80575975
131Vomiting (HP:0002013)1.78743294
132Delayed epiphyseal ossification (HP:0002663)1.78539745
133Alopecia of scalp (HP:0002293)1.77683796
134Brushfield spots (HP:0001088)1.77351457
135Sensorimotor neuropathy (HP:0007141)1.76985297
136White forelock (HP:0002211)1.76661079
137Abnormality of transition element cation homeostasis (HP:0011030)1.76160052
138Visceral angiomatosis (HP:0100761)1.75129669
139Advanced eruption of teeth (HP:0006288)1.74586572
140Turricephaly (HP:0000262)1.74221711
141Pterygium (HP:0001059)1.73810467
142Paraparesis (HP:0002385)1.73763372
143Enlarged kidneys (HP:0000105)1.73038235
144Abnormality of the gallbladder (HP:0005264)1.72331576
145Hypoglycemic seizures (HP:0002173)1.72238591
146Degeneration of the lateral corticospinal tracts (HP:0002314)1.71578694
147Hyperuricemia (HP:0002149)1.71507638
148Increased purine levels (HP:0004368)1.71507638
149Small epiphyses (HP:0010585)1.69792778
150Neonatal death (HP:0003811)1.69725356
151Woolly hair (HP:0002224)1.68619443
152Abnormality of the dental root (HP:0006486)1.67793544
153Taurodontia (HP:0000679)1.67793544
154Abnormality of permanent molar morphology (HP:0011071)1.67793544
155Hemangiomatosis (HP:0007461)1.65360427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.55002990
2EPHB13.55503062
3MST1R3.41215414
4MET3.40438240
5BCKDK3.21175746
6OXSR13.06488419
7EPHA22.89252272
8PKN22.73211150
9FRK2.68638359
10MAPKAPK32.60211123
11SIK12.53919607
12FGFR42.53174267
13MST42.40305784
14ERN12.35627202
15LATS12.32283377
16FGFR32.31590331
17ERBB42.30872436
18FGFR22.30322583
19EEF2K2.30261683
20WNK42.19296466
21CDK122.11685351
22ICK1.88495246
23RPS6KB21.80060984
24PBK1.74942957
25PTK61.65900201
26LMTK21.60194211
27SMG11.54425443
28BCR1.51030274
29TAOK31.43664815
30INSRR1.42718913
31MAP2K21.41546358
32MAP3K21.38243605
33PDGFRA1.27151113
34PIK3CG1.21157174
35ACVR1B1.20156090
36PTK21.13623464
37FER1.12380532
38AKT31.12233504
39MAP3K71.10453453
40FGFR11.08225007
41WNK11.07510769
42PKN11.06258733
43CSNK1G11.05205656
44MAPK151.00944125
45CSNK1A1L0.98318373
46MAP3K30.96233753
47EPHB20.95489046
48PAK30.90109345
49CDK70.89546880
50CSNK1G30.87701904
51GSK3A0.86863183
52SCYL20.86435569
53PAK40.85980944
54MAPK110.85805140
55PRKAA20.85169358
56STK100.83383846
57CAMK2G0.80063698
58NUAK10.78389545
59EPHA30.78152294
60GRK60.77663354
61BMX0.74114416
62RPS6KB10.71301594
63PIK3CA0.67621009
64RIPK10.67445968
65NME10.67101198
66MATK0.66365736
67PRKG20.66078901
68PRKD30.65393964
69CDC42BPA0.64946849
70PDPK10.64644359
71MUSK0.63437602
72PRKCQ0.63399124
73STK30.61680199
74RPS6KA20.61167811
75CHUK0.60582047
76GRK10.60358382
77DYRK1B0.59857803
78NTRK10.59399977
79EIF2AK10.58879999
80TESK10.58879022
81MAP2K60.58332342
82CSNK1G20.58237716
83CAMK1D0.58156944
84LIMK10.57343056
85CSK0.56225413
86STK38L0.55785602
87DDR20.54797111
88PRKD20.54357418
89DMPK0.52276440
90TESK20.51562255
91MAP2K40.51532452
92CAMK2B0.51401609
93MAP2K10.50575119
94CSNK1E0.50427894
95SGK30.49880456
96LATS20.47308521
97CAMK2D0.46785672
98IRAK10.46294172
99CDK60.45613737
100MAPK70.45603316
101JAK20.45467307
102PDK10.45216359
103SGK2230.45025215
104SGK4940.45025215
105PRKD10.44896337
106ABL20.44586665
107TRPM70.44450092
108ROCK20.44356518
109MAPKAPK50.43565241
110TYRO30.43037250
111KSR20.42771090
112SGK10.42765947
113MAP3K120.42594141
114LRRK20.42360361
115RET0.42103697
116TNIK0.42029499
117CDK190.41251255
118MTOR0.41137022
119NEK60.41133451
120EPHA40.40914313
121CAMK1G0.39186028
122* ERBB20.38870147
123SGK20.38651530
124MAP3K10.37594454
125IRAK20.37426969
126MAP3K100.37342636
127PRKCZ0.37234540
128MARK20.36628056
129STK240.35680397
130MELK0.35486450
131PDGFRB0.35243160
132PRKCI0.34913417
133TYK20.34453890
134FGR0.34057676
135PRKAA10.33187452
136CSNK1A10.32201265
137SRC0.31219683
138TRIB30.30758407
139CASK0.29549732
140STK380.28636095
141MAPKAPK20.28093886
142AKT20.28008814

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.77297472
2Nitrogen metabolism_Homo sapiens_hsa009103.23891288
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16667841
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65066667
5Arginine biosynthesis_Homo sapiens_hsa002202.52975512
6Tryptophan metabolism_Homo sapiens_hsa003802.46017949
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.42972320
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33216189
9Histidine metabolism_Homo sapiens_hsa003402.32988899
10Fatty acid degradation_Homo sapiens_hsa000712.32803726
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.32079134
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30420435
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30194612
14Sulfur metabolism_Homo sapiens_hsa009202.29739286
15Butanoate metabolism_Homo sapiens_hsa006502.20112484
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19906038
17Complement and coagulation cascades_Homo sapiens_hsa046102.12794736
18Steroid biosynthesis_Homo sapiens_hsa001002.09498226
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06674296
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00643069
21Chemical carcinogenesis_Homo sapiens_hsa052041.97807192
22Caffeine metabolism_Homo sapiens_hsa002321.96596488
23Fatty acid elongation_Homo sapiens_hsa000621.95052751
24Peroxisome_Homo sapiens_hsa041461.91060743
25Propanoate metabolism_Homo sapiens_hsa006401.83364333
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.81929568
27PPAR signaling pathway_Homo sapiens_hsa033201.80503642
28Fat digestion and absorption_Homo sapiens_hsa049751.80036286
29Fatty acid metabolism_Homo sapiens_hsa012121.78976222
30Retinol metabolism_Homo sapiens_hsa008301.67854820
31Bile secretion_Homo sapiens_hsa049761.64716671
32beta-Alanine metabolism_Homo sapiens_hsa004101.63358986
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50692121
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42253597
35Vitamin digestion and absorption_Homo sapiens_hsa049771.39123067
36Folate biosynthesis_Homo sapiens_hsa007901.39020072
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.37446501
38ABC transporters_Homo sapiens_hsa020101.33504785
39Starch and sucrose metabolism_Homo sapiens_hsa005001.33228227
40Selenocompound metabolism_Homo sapiens_hsa004501.32460515
41Phenylalanine metabolism_Homo sapiens_hsa003601.32432626
42Tyrosine metabolism_Homo sapiens_hsa003501.30101157
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24756284
44Pyruvate metabolism_Homo sapiens_hsa006201.22515046
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19550607
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18272975
47Staphylococcus aureus infection_Homo sapiens_hsa051501.15418142
48Arginine and proline metabolism_Homo sapiens_hsa003301.14950117
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.13042486
50Glutathione metabolism_Homo sapiens_hsa004801.10172011
51Vitamin B6 metabolism_Homo sapiens_hsa007501.05745914
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03247471
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.99989033
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.98745826
55Carbon metabolism_Homo sapiens_hsa012000.95318168
56Other glycan degradation_Homo sapiens_hsa005110.90599476
57Biosynthesis of amino acids_Homo sapiens_hsa012300.89474112
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88934342
59Glycerolipid metabolism_Homo sapiens_hsa005610.84943462
60Sulfur relay system_Homo sapiens_hsa041220.81645680
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78004095
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77335740
63Lysine degradation_Homo sapiens_hsa003100.74522921
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72427456
65Fatty acid biosynthesis_Homo sapiens_hsa000610.71442569
66Linoleic acid metabolism_Homo sapiens_hsa005910.71099198
67Mineral absorption_Homo sapiens_hsa049780.65858571
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61801781
69Thyroid cancer_Homo sapiens_hsa052160.60890137
70Glucagon signaling pathway_Homo sapiens_hsa049220.60315244
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.59746795
72Pancreatic secretion_Homo sapiens_hsa049720.56770522
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55029360
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55027844
75N-Glycan biosynthesis_Homo sapiens_hsa005100.54748608
76Pentose phosphate pathway_Homo sapiens_hsa000300.53064023
77Ether lipid metabolism_Homo sapiens_hsa005650.52191750
78Metabolic pathways_Homo sapiens_hsa011000.49433348
79Renin-angiotensin system_Homo sapiens_hsa046140.42841839
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.39805391
81Galactose metabolism_Homo sapiens_hsa000520.39569505
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38770740
83Fructose and mannose metabolism_Homo sapiens_hsa000510.37114257
84Endometrial cancer_Homo sapiens_hsa052130.36434929
85Insulin signaling pathway_Homo sapiens_hsa049100.35272322
86Choline metabolism in cancer_Homo sapiens_hsa052310.32270132
87Protein digestion and absorption_Homo sapiens_hsa049740.31461208
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30503333
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28374489
90Tight junction_Homo sapiens_hsa045300.26510568
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24697187
92Inositol phosphate metabolism_Homo sapiens_hsa005620.22134272
93Sphingolipid metabolism_Homo sapiens_hsa006000.21504226
94Arachidonic acid metabolism_Homo sapiens_hsa005900.21350150
95Prion diseases_Homo sapiens_hsa050200.16677323
96One carbon pool by folate_Homo sapiens_hsa006700.15809744
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.15247301
98Insulin resistance_Homo sapiens_hsa049310.15099821
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.14269986
100ECM-receptor interaction_Homo sapiens_hsa045120.11432601
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08324662
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07547343
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04740105
104Hepatitis C_Homo sapiens_hsa051600.02837532
105AMPK signaling pathway_Homo sapiens_hsa041520.02638883
106Ovarian steroidogenesis_Homo sapiens_hsa049130.00787539
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1138327
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1102989
109Adherens junction_Homo sapiens_hsa04520-0.0842126
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0483563
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0387431
112Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0355435
113Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0326315
114Amoebiasis_Homo sapiens_hsa05146-0.0134887
115Bladder cancer_Homo sapiens_hsa05219-0.0067145

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