ERBB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of activin receptor signaling pathway (GO:0032926)9.05036292
2regulation of mesoderm development (GO:2000380)8.73622434
3anterior/posterior axis specification, embryo (GO:0008595)8.40780178
4cell migration involved in gastrulation (GO:0042074)7.37490177
5sequestering of extracellular ligand from receptor (GO:0035581)6.90150762
6regulation of activin receptor signaling pathway (GO:0032925)6.82804434
7anterior/posterior axis specification (GO:0009948)6.27683254
8nodal signaling pathway (GO:0038092)6.25758746
9signal transduction involved in regulation of gene expression (GO:0023019)6.24426429
10phospholipid scrambling (GO:0017121)6.10424144
11somite rostral/caudal axis specification (GO:0032525)6.08932543
12regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.03406289
13neuron cell-cell adhesion (GO:0007158)5.99215778
14vocalization behavior (GO:0071625)5.68520494
15embryonic axis specification (GO:0000578)5.61960836
16endoderm formation (GO:0001706)5.61500777
17regulation of acyl-CoA biosynthetic process (GO:0050812)5.53106161
18branching involved in labyrinthine layer morphogenesis (GO:0060670)5.48034488
19regulation of cofactor metabolic process (GO:0051193)5.44528398
20regulation of coenzyme metabolic process (GO:0051196)5.44528398
21L-serine transport (GO:0015825)5.39579086
22regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31397846
23presynaptic membrane assembly (GO:0097105)4.96789099
24primitive streak formation (GO:0090009)4.91562139
25gamma-aminobutyric acid transport (GO:0015812)4.79014541
26presynaptic membrane organization (GO:0097090)4.74382469
27positive regulation of gastrulation (GO:2000543)4.73425657
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.66596621
29axon ensheathment in central nervous system (GO:0032291)4.61478523
30central nervous system myelination (GO:0022010)4.61478523
31regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.59273151
32response to BMP (GO:0071772)4.56533589
33cellular response to BMP stimulus (GO:0071773)4.56533589
34locomotory exploration behavior (GO:0035641)4.56380040
35synaptic vesicle exocytosis (GO:0016079)4.55689905
36serine transport (GO:0032329)4.48797779
37neuronal action potential propagation (GO:0019227)4.42056070
38L-ascorbic acid metabolic process (GO:0019852)4.41786765
39regulation of sulfur metabolic process (GO:0042762)4.36405643
40regulation of glutamate receptor signaling pathway (GO:1900449)4.32434438
41embryonic camera-type eye development (GO:0031076)4.27302494
42* embryonic pattern specification (GO:0009880)4.26664720
43limb bud formation (GO:0060174)4.24012533
44negative regulation of keratinocyte proliferation (GO:0010839)4.21241858
45ionotropic glutamate receptor signaling pathway (GO:0035235)4.18872926
46synaptic vesicle maturation (GO:0016188)4.15144756
47protein localization to synapse (GO:0035418)4.13465811
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11684973
49gastrulation (GO:0007369)4.10287530
50negative regulation of synaptic transmission, GABAergic (GO:0032229)4.10165467
51glutamate secretion (GO:0014047)4.09463941
52neuron recognition (GO:0008038)4.05662755
53transmission of nerve impulse (GO:0019226)4.04172709
54neurotransmitter-gated ion channel clustering (GO:0072578)4.03666699
55regulation of tight junction assembly (GO:2000810)4.02159259
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99690829
57regulation of synaptic vesicle exocytosis (GO:2000300)3.98991743
58kidney morphogenesis (GO:0060993)3.97741486
59extracellular regulation of signal transduction (GO:1900115)3.97227094
60extracellular negative regulation of signal transduction (GO:1900116)3.97227094
61SMAD protein signal transduction (GO:0060395)3.92940198
62neurotransmitter secretion (GO:0007269)3.92673062
63axis specification (GO:0009798)3.87693506
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.85864598
65fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.85232389
66neuron-neuron synaptic transmission (GO:0007270)3.81107157
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.78398518
68layer formation in cerebral cortex (GO:0021819)3.74823522
69regulation of timing of cell differentiation (GO:0048505)3.74436055
70regulation of development, heterochronic (GO:0040034)3.71208206
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.71096329
72synaptic transmission, glutamatergic (GO:0035249)3.68204500
73exploration behavior (GO:0035640)3.66877010
74startle response (GO:0001964)3.66788429
75embryonic foregut morphogenesis (GO:0048617)3.66004042
76dendritic spine morphogenesis (GO:0060997)3.63860126
77negative regulation of neurotransmitter transport (GO:0051589)3.59369509
78regulation of gastrulation (GO:0010470)3.56537852
79glutamate receptor signaling pathway (GO:0007215)3.55491138
80cerebellar granule cell differentiation (GO:0021707)3.55355712
81postsynaptic membrane organization (GO:0001941)3.54043370
82negative regulation of neurotransmitter secretion (GO:0046929)3.53884286
83female gonad development (GO:0008585)3.53395524
84activin receptor signaling pathway (GO:0032924)3.53065100
85membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52958387
86DNA replication-dependent nucleosome assembly (GO:0006335)3.51893892
87DNA replication-dependent nucleosome organization (GO:0034723)3.51893892
88regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50010619
89cardiac right ventricle morphogenesis (GO:0003215)3.46632032
90regulation of neuronal synaptic plasticity (GO:0048168)3.45468822
91regulation of synaptic vesicle transport (GO:1902803)3.42494301
92neuronal ion channel clustering (GO:0045161)3.42455940
93positive regulation of synapse assembly (GO:0051965)3.40838958
94pericardium development (GO:0060039)3.38737878
95positive regulation of membrane potential (GO:0045838)3.38486029
96axonal fasciculation (GO:0007413)3.36519647
97dendrite morphogenesis (GO:0048813)3.34949011
98positive regulation of synapse maturation (GO:0090129)3.32551908
99glycosphingolipid biosynthetic process (GO:0006688)3.31909427
100neurotransmitter transport (GO:0006836)3.29940975
101long-chain fatty acid biosynthetic process (GO:0042759)3.28398239
102regulation of synapse structural plasticity (GO:0051823)3.27546705
103adult walking behavior (GO:0007628)3.27519192
104dorsal/ventral axis specification (GO:0009950)3.27012844
105digestive tract morphogenesis (GO:0048546)3.24860403
106membrane hyperpolarization (GO:0060081)3.23526319
107positive regulation of action potential (GO:0045760)3.23479617
108regulation of synaptic transmission, glutamatergic (GO:0051966)3.22442311
109synapse assembly (GO:0007416)3.22419918
110histone exchange (GO:0043486)3.21345039
111long-term memory (GO:0007616)3.20282799
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20035173
113regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19786583
114regulation of synaptic transmission, GABAergic (GO:0032228)3.19414091
115L-amino acid import (GO:0043092)3.19208235
116otic vesicle formation (GO:0030916)3.18760378
117regulation of dendritic spine morphogenesis (GO:0061001)3.16084989
118fatty acid elongation (GO:0030497)3.12130507
119DNA double-strand break processing (GO:0000729)3.09173096
120chromatin remodeling at centromere (GO:0031055)3.08436744
121regulation of postsynaptic membrane potential (GO:0060078)3.06115850
122cerebral cortex radially oriented cell migration (GO:0021799)3.05615888
123regulation of neurotransmitter levels (GO:0001505)3.04588574
124cell migration in hindbrain (GO:0021535)3.03954597
125auditory behavior (GO:0031223)3.03041151
126synapse organization (GO:0050808)3.00959333
127long-term synaptic potentiation (GO:0060291)3.00495344
128amino acid import (GO:0043090)2.99865977
129prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.98853589
130myelination (GO:0042552)2.96724721
131peptidyl-cysteine modification (GO:0018198)2.95694199
132fat-soluble vitamin catabolic process (GO:0042363)2.93404797
133vitamin catabolic process (GO:0009111)2.93404797
134dendrite development (GO:0016358)2.93125296
135ensheathment of neurons (GO:0007272)2.92215776
136axon ensheathment (GO:0008366)2.92215776
137learning (GO:0007612)2.91926193
138CENP-A containing nucleosome assembly (GO:0034080)2.88340462
139regulation of synapse maturation (GO:0090128)2.87566854
140Rap protein signal transduction (GO:0032486)2.87479667
141regulation of synapse assembly (GO:0051963)2.86881181
142mating behavior (GO:0007617)2.86358500
143establishment of mitochondrion localization (GO:0051654)2.86242954
144mechanosensory behavior (GO:0007638)2.85821328
145positive regulation of synaptic transmission, GABAergic (GO:0032230)2.84235577
146central nervous system projection neuron axonogenesis (GO:0021952)2.84075651
147regulation of dendritic spine development (GO:0060998)2.83947986
148behavioral response to cocaine (GO:0048148)2.83540023
149response to auditory stimulus (GO:0010996)2.83031403
150proline transport (GO:0015824)2.81599888
151pyrimidine nucleobase catabolic process (GO:0006208)2.81352450
152regulation of synaptic plasticity (GO:0048167)2.80439618
153positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.80297512
154negative regulation of synaptic transmission (GO:0050805)2.80085908
155short-term memory (GO:0007614)2.79680591
156striatum development (GO:0021756)2.78579669
157membrane assembly (GO:0071709)2.77120190
158regulation of neurotransmitter secretion (GO:0046928)2.76300055
159regulation of keratinocyte proliferation (GO:0010837)2.76078907
160synaptic vesicle docking involved in exocytosis (GO:0016081)2.73179567
161ureteric bud development (GO:0001657)2.72749757
162membrane depolarization (GO:0051899)2.72142440
163adult behavior (GO:0030534)2.71430286
164negative regulation of axonogenesis (GO:0050771)2.70321161
165dorsal/ventral pattern formation (GO:0009953)2.69680631
166genitalia morphogenesis (GO:0035112)2.68071247
167tricarboxylic acid cycle (GO:0006099)2.67956801
168negative regulation of androgen receptor signaling pathway (GO:0060766)2.67753459
169protein autoprocessing (GO:0016540)2.65429055
170regulation of penile erection (GO:0060405)2.62985648
171acetyl-CoA metabolic process (GO:0006084)2.62058531
172DNA replication checkpoint (GO:0000076)2.61900573
173positive regulation of SMAD protein import into nucleus (GO:0060391)2.60060144
174behavioral response to ethanol (GO:0048149)2.59818847
175nonmotile primary cilium assembly (GO:0035058)2.59534399
176regulation of actin cytoskeleton reorganization (GO:2000249)2.55186946
177behavioral defense response (GO:0002209)2.53377140
178behavioral fear response (GO:0001662)2.53377140
179branched-chain amino acid catabolic process (GO:0009083)2.50917844
180mitotic G2/M transition checkpoint (GO:0044818)2.50635489
181negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.48013775
182neuron fate determination (GO:0048664)2.47234326
183regulation of collateral sprouting (GO:0048670)2.45134420
184* positive regulation of cardiac muscle cell proliferation (GO:0060045)2.42720485
185response to pheromone (GO:0019236)2.42701989
186outflow tract septum morphogenesis (GO:0003148)2.41643096
187regulation of cardioblast differentiation (GO:0051890)2.40638421
188tachykinin receptor signaling pathway (GO:0007217)2.39885449
189regulation of glucokinase activity (GO:0033131)2.39465407
190regulation of hexokinase activity (GO:1903299)2.39465407
191germ cell migration (GO:0008354)2.36174265
192mesonephric tubule development (GO:0072164)2.35340158
193multicellular organismal aging (GO:0010259)2.35226811
194regulation of axon extension involved in axon guidance (GO:0048841)2.34009687
195regulation of hippo signaling (GO:0035330)2.32121630
196* positive regulation of cardiac muscle tissue growth (GO:0055023)2.31607380
197mesonephric epithelium development (GO:0072163)2.30919818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42404511
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.88578001
3GBX2_23144817_ChIP-Seq_PC3_Human4.12642460
4SMAD3_21741376_ChIP-Seq_HESCs_Human3.18928224
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95805417
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91869803
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91641230
8SMAD4_21741376_ChIP-Seq_HESCs_Human2.71713485
9TAF15_26573619_Chip-Seq_HEK293_Human2.68364612
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.63638230
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.63638230
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.63638230
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.47673313
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47363580
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47363580
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41566901
17* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39808863
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36247991
19* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.33109017
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28034880
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24701029
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.24360536
23* FLI1_27457419_Chip-Seq_LIVER_Mouse2.22645651
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22401515
25REST_21632747_ChIP-Seq_MESCs_Mouse2.21187592
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21125330
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.14935658
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10646781
29WT1_19549856_ChIP-ChIP_CCG9911_Human2.09828801
30DROSHA_22980978_ChIP-Seq_HELA_Human2.08103940
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06272103
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05261327
33* EZH2_27294783_Chip-Seq_ESCs_Mouse2.03870889
34* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00086220
35* RNF2_27304074_Chip-Seq_ESCs_Mouse1.99433252
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97468556
37* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95020028
38AR_21572438_ChIP-Seq_LNCaP_Human1.94806510
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.86979226
40SMAD4_21741376_ChIP-Seq_EPCs_Human1.82640429
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.81774209
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79808203
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78222649
44E2F7_22180533_ChIP-Seq_HELA_Human1.76029664
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74887547
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74323055
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.71812075
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71732126
49* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67661462
50SMAD4_21799915_ChIP-Seq_A2780_Human1.67336553
51* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66912094
52P300_19829295_ChIP-Seq_ESCs_Human1.65763233
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64245864
54IGF1R_20145208_ChIP-Seq_DFB_Human1.63789731
55EWS_26573619_Chip-Seq_HEK293_Human1.62783563
56BCAT_22108803_ChIP-Seq_LS180_Human1.60857778
57* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60660975
58EOMES_21245162_ChIP-Seq_HESCs_Human1.59759712
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.59700447
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57818819
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.57811335
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56439497
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53013676
64FUS_26573619_Chip-Seq_HEK293_Human1.51774536
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50354205
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.47456100
67ER_23166858_ChIP-Seq_MCF-7_Human1.46415930
68ZNF274_21170338_ChIP-Seq_K562_Hela1.45795437
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44386207
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44097390
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41277190
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39606085
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39094829
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38951425
75* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36954044
76VDR_22108803_ChIP-Seq_LS180_Human1.34459691
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.33402916
78RNF2_27304074_Chip-Seq_NSC_Mouse1.33343473
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32474551
80CBP_20019798_ChIP-Seq_JUKART_Human1.30840908
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30840908
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.29343122
83* STAT3_23295773_ChIP-Seq_U87_Human1.29312282
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26422610
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26049713
86* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25657726
87* AR_25329375_ChIP-Seq_VCAP_Human1.25211954
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.23407361
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22241858
90* EZH2_27294783_Chip-Seq_NPCs_Mouse1.22222466
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.21846175
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21620975
93NANOG_19829295_ChIP-Seq_ESCs_Human1.21087642
94SOX2_19829295_ChIP-Seq_ESCs_Human1.21087642
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20447164
96TCF4_22108803_ChIP-Seq_LS180_Human1.19770362
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19717306
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18738369
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18738369
100* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18552330
101* RING1B_27294783_Chip-Seq_ESCs_Mouse1.18055617
102* TCF4_23295773_ChIP-Seq_U87_Human1.16936037
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15627826
104AHR_22903824_ChIP-Seq_MCF-7_Human1.14762245
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14582828
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13176916
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12497250
108* NFE2_27457419_Chip-Seq_LIVER_Mouse1.11976750
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11768253
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11624058
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11149875
112RUNX2_22187159_ChIP-Seq_PCA_Human1.09873253
113* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09716566
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09690746
115* ERG_21242973_ChIP-ChIP_JURKAT_Human1.08918403
116CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07203318
117* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06587023
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06181751
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06087791
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06087791
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05862916
122* AR_19668381_ChIP-Seq_PC3_Human1.05824504
123* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05184085
124* NANOG_18555785_Chip-Seq_ESCs_Mouse1.04643993
125* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04466877
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04455683
127* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03993244
128* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03986025
129* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03452853
130MYC_18940864_ChIP-ChIP_HL60_Human1.03386803
131JUN_21703547_ChIP-Seq_K562_Human1.02277417
132* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02248855
133TP53_22573176_ChIP-Seq_HFKS_Human1.00719190
134TP53_18474530_ChIP-ChIP_U2OS_Human1.00148614
135* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00117139
136E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98203198
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97885579
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96618133
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96036037
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95432007
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95413106
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93920371
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93919246
144* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93210492
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93124921
146* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90976156
147SOX9_26525672_Chip-Seq_HEART_Mouse0.90282597
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89194368
149SMAD3_21741376_ChIP-Seq_ESCs_Human0.88830014
150KDM2B_26808549_Chip-Seq_REH_Human0.88695411
151* TP53_16413492_ChIP-PET_HCT116_Human0.88178506
152RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87979813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.96379064
2MP0008004_abnormal_stomach_pH5.09419156
3MP0004859_abnormal_synaptic_plasticity4.97169059
4MP0003880_abnormal_central_pattern4.61460385
5* MP0003635_abnormal_synaptic_transmissio3.64988199
6MP0009046_muscle_twitch3.46491349
7MP0004133_heterotaxia3.35598722
8MP0003119_abnormal_digestive_system3.31491852
9MP0009745_abnormal_behavioral_response3.30308740
10MP0004270_analgesia3.27669903
11MP0002064_seizures3.24624905
12MP0010030_abnormal_orbit_morphology3.03040114
13MP0002063_abnormal_learning/memory/cond2.94477281
14MP0001486_abnormal_startle_reflex2.89509202
15MP0002272_abnormal_nervous_system2.73958535
16MP0006292_abnormal_olfactory_placode2.73548768
17MP0002822_catalepsy2.70103566
18MP0002572_abnormal_emotion/affect_behav2.65553770
19MP0005423_abnormal_somatic_nervous2.63762601
20MP0002734_abnormal_mechanical_nocicepti2.38060120
21MP0000778_abnormal_nervous_system2.32419952
22MP0004264_abnormal_extraembryonic_tissu2.27790405
23MP0002735_abnormal_chemical_nociception2.21086886
24MP0001968_abnormal_touch/_nociception2.19486126
25MP0002277_abnormal_respiratory_mucosa2.18323541
26MP0003329_amyloid_beta_deposits2.13490045
27MP0001529_abnormal_vocalization2.04897975
28MP0002067_abnormal_sensory_capabilities2.00867851
29MP0001501_abnormal_sleep_pattern1.96523710
30MP0000920_abnormal_myelination1.96000916
31MP0001440_abnormal_grooming_behavior1.92204304
32MP0004885_abnormal_endolymph1.88240969
33MP0008789_abnormal_olfactory_epithelium1.85446599
34MP0005386_behavior/neurological_phenoty1.84416641
35MP0004924_abnormal_behavior1.84416641
36MP0006276_abnormal_autonomic_nervous1.83431719
37MP0001905_abnormal_dopamine_level1.81587364
38MP0004142_abnormal_muscle_tone1.79047717
39MP0008569_lethality_at_weaning1.78559674
40MP0005646_abnormal_pituitary_gland1.77232568
41MP0002733_abnormal_thermal_nociception1.75028831
42MP0002557_abnormal_social/conspecific_i1.73596868
43MP0001970_abnormal_pain_threshold1.72789071
44* MP0002184_abnormal_innervation1.72308321
45MP0002736_abnormal_nociception_after1.72097554
46MP0002234_abnormal_pharynx_morphology1.57820919
47MP0009780_abnormal_chondrocyte_physiolo1.57770735
48MP0002233_abnormal_nose_morphology1.57281951
49MP0000516_abnormal_urinary_system1.56049035
50MP0005367_renal/urinary_system_phenotyp1.56049035
51MP0002938_white_spotting1.53326155
52* MP0002882_abnormal_neuron_morphology1.51865077
53* MP0000955_abnormal_spinal_cord1.49447509
54* MP0002066_abnormal_motor_capabilities/c1.49073506
55MP0004811_abnormal_neuron_physiology1.48450453
56MP0004742_abnormal_vestibular_system1.47945736
57MP0001984_abnormal_olfaction1.46167959
58MP0002254_reproductive_system_inflammat1.44738113
59MP0003283_abnormal_digestive_organ1.44717780
60MP0003937_abnormal_limbs/digits/tail_de1.44039615
61MP0001286_abnormal_eye_development1.41651140
62MP0003690_abnormal_glial_cell1.40594179
63MP0001986_abnormal_taste_sensitivity1.40580119
64MP0003787_abnormal_imprinting1.39980512
65MP0003122_maternal_imprinting1.37861390
66MP0001188_hyperpigmentation1.34633915
67MP0001293_anophthalmia1.32267432
68MP0003634_abnormal_glial_cell1.28882814
69MP0002751_abnormal_autonomic_nervous1.28707712
70MP0000428_abnormal_craniofacial_morphol1.26840377
71MP0003632_abnormal_nervous_system1.26302792
72MP0001485_abnormal_pinna_reflex1.24246556
73MP0003385_abnormal_body_wall1.23827308
74MP0000049_abnormal_middle_ear1.23264687
75MP0005645_abnormal_hypothalamus_physiol1.22712973
76MP0005171_absent_coat_pigmentation1.21861850
77MP0000372_irregular_coat_pigmentation1.21012946
78MP0002229_neurodegeneration1.20955423
79MP0003567_abnormal_fetal_cardiomyocyte1.20433169
80MP0006072_abnormal_retinal_apoptosis1.19085215
81* MP0002152_abnormal_brain_morphology1.19016344
82MP0001963_abnormal_hearing_physiology1.16818647
83MP0003631_nervous_system_phenotype1.14323472
84MP0003879_abnormal_hair_cell1.08678168
85MP0004858_abnormal_nervous_system1.08503209
86MP0001177_atelectasis1.07979334
87MP0005084_abnormal_gallbladder_morpholo1.07245451
88MP0005551_abnormal_eye_electrophysiolog1.06754741
89MP0003633_abnormal_nervous_system1.06699779
90MP0003935_abnormal_craniofacial_develop1.06043492
91MP0002084_abnormal_developmental_patter1.03485247
92MP0003195_calcinosis1.02678942
93MP0002909_abnormal_adrenal_gland1.00338026
94MP0005409_darkened_coat_color1.00320370
95MP0001502_abnormal_circadian_rhythm0.98918833
96MP0008995_early_reproductive_senescence0.98096682
97MP0000631_abnormal_neuroendocrine_gland0.98025715
98* MP0002752_abnormal_somatic_nervous0.97228895
99MP0000751_myopathy0.96454598
100* MP0004085_abnormal_heartbeat0.93762532
101MP0002837_dystrophic_cardiac_calcinosis0.93713533
102MP0000604_amyloidosis0.93322730
103MP0002111_abnormal_tail_morphology0.93166722
104MP0003943_abnormal_hepatobiliary_system0.91310067
105MP0010386_abnormal_urinary_bladder0.86939992
106MP0000026_abnormal_inner_ear0.86909711
107MP0000383_abnormal_hair_follicle0.86065451
108MP0002069_abnormal_eating/drinking_beha0.85032699
109MP0005187_abnormal_penis_morphology0.83718660
110MP0000647_abnormal_sebaceous_gland0.83220045
111* MP0003137_abnormal_impulse_conducting0.82862930
112MP0001299_abnormal_eye_distance/0.81582561
113MP0003938_abnormal_ear_development0.80441087
114MP0003136_yellow_coat_color0.80137940
115MP0005248_abnormal_Harderian_gland0.78358100
116MP0000569_abnormal_digit_pigmentation0.76609936
117MP0004215_abnormal_myocardial_fiber0.75013871
118MP0002085_abnormal_embryonic_tissue0.75004287
119MP0001672_abnormal_embryogenesis/_devel0.74707617
120MP0005380_embryogenesis_phenotype0.74707617
121MP0004145_abnormal_muscle_electrophysio0.74681365
122MP0004043_abnormal_pH_regulation0.73147943
123MP0008872_abnormal_physiological_respon0.72227664
124MP0003221_abnormal_cardiomyocyte_apopto0.72118831
125MP0004147_increased_porphyrin_level0.71805749
126* MP0003861_abnormal_nervous_system0.71125835
127MP0002102_abnormal_ear_morphology0.69535838
128MP0000566_synostosis0.69495436
129MP0000470_abnormal_stomach_morphology0.68674299
130MP0001943_abnormal_respiration0.68266259
131MP0000537_abnormal_urethra_morphology0.68016534
132MP0002109_abnormal_limb_morphology0.67662338
133MP0000427_abnormal_hair_cycle0.67208067
134MP0002697_abnormal_eye_size0.65642075
135MP0003755_abnormal_palate_morphology0.65375589
136MP0002082_postnatal_lethality0.64450159
137MP0010770_preweaning_lethality0.64450159
138MP0002090_abnormal_vision0.64207637
139MP0002638_abnormal_pupillary_reflex0.63822854
140MP0010769_abnormal_survival0.62159775
141MP0004134_abnormal_chest_morphology0.60671712
142MP0006035_abnormal_mitochondrial_morpho0.60191869
143MP0001664_abnormal_digestion0.59899205
144MP0010094_abnormal_chromosome_stability0.59591537
145MP0005499_abnormal_olfactory_system0.59466238
146MP0005394_taste/olfaction_phenotype0.59466238
147MP0000462_abnormal_digestive_system0.58444026
148MP0010768_mortality/aging0.57998241
149MP0008877_abnormal_DNA_methylation0.57818962
150MP0000013_abnormal_adipose_tissue0.57747898
151MP0000762_abnormal_tongue_morphology0.56387795
152MP0009703_decreased_birth_body0.55834723
153MP0002138_abnormal_hepatobiliary_system0.55724608
154MP0005195_abnormal_posterior_eye0.54398198
155MP0008058_abnormal_DNA_repair0.54296945

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.14871483
2Congenital malformation of the right heart (HP:0011723)6.66817960
3Double outlet right ventricle (HP:0001719)6.66817960
4Intestinal atresia (HP:0011100)6.30477539
5Oligodactyly (hands) (HP:0001180)5.70038024
6Abnormality of the parathyroid morphology (HP:0011766)5.43244911
7Atonic seizures (HP:0010819)5.14368375
8Myokymia (HP:0002411)4.72414946
9Focal seizures (HP:0007359)4.71681800
10Epileptic encephalopathy (HP:0200134)4.56400709
11Hyperventilation (HP:0002883)4.50960719
12Chin dimple (HP:0010751)4.50762715
13Esophageal atresia (HP:0002032)4.42291901
14Febrile seizures (HP:0002373)4.27036081
15Abdominal situs inversus (HP:0003363)4.19653944
16Abnormality of abdominal situs (HP:0011620)4.19653944
17Anal stenosis (HP:0002025)4.09582896
18Abnormality of alanine metabolism (HP:0010916)4.04264950
19Hyperalaninemia (HP:0003348)4.04264950
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.04264950
21Oligodactyly (HP:0012165)3.87837055
22Anophthalmia (HP:0000528)3.79706492
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.65461783
24Degeneration of the lateral corticospinal tracts (HP:0002314)3.65461783
25Absence seizures (HP:0002121)3.63169124
26Abnormality of the corticospinal tract (HP:0002492)3.54712764
27Absent radius (HP:0003974)3.52373386
28Neurofibrillary tangles (HP:0002185)3.51847984
29Labial hypoplasia (HP:0000066)3.51592009
30Septo-optic dysplasia (HP:0100842)3.50960193
31Nuclear cataract (HP:0100018)3.50807263
32Dialeptic seizures (HP:0011146)3.48963742
33Broad-based gait (HP:0002136)3.45101757
34Aplasia involving forearm bones (HP:0009822)3.40423686
35Absent forearm bone (HP:0003953)3.40423686
36Deep palmar crease (HP:0006191)3.36994979
37Bifid tongue (HP:0010297)3.34886635
38Ankle clonus (HP:0011448)3.26259462
39Pheochromocytoma (HP:0002666)3.23170285
40Limb dystonia (HP:0002451)3.20582390
41Hypoplastic female external genitalia (HP:0012815)3.17867009
42Down-sloping shoulders (HP:0200021)3.14562600
43Spastic gait (HP:0002064)3.10176475
44Cupped ear (HP:0000378)3.09636413
45Supranuclear gaze palsy (HP:0000605)3.08747141
46Gastrointestinal atresia (HP:0002589)3.08736584
47Progressive cerebellar ataxia (HP:0002073)3.04740486
48Mixed hearing impairment (HP:0000410)3.04214699
49Abnormal pancreas size (HP:0012094)3.00678105
50Generalized tonic-clonic seizures (HP:0002069)2.97942749
51Visual hallucinations (HP:0002367)2.89108482
52Neuroendocrine neoplasm (HP:0100634)2.86714973
53Cerebral inclusion bodies (HP:0100314)2.85323567
54Anosmia (HP:0000458)2.83214396
55Hemivertebrae (HP:0002937)2.82159823
56Absent speech (HP:0001344)2.81698008
57Gaze-evoked nystagmus (HP:0000640)2.78885548
58Dysmetria (HP:0001310)2.75852416
59Drooling (HP:0002307)2.74623305
60Excessive salivation (HP:0003781)2.74623305
61Termporal pattern (HP:0011008)2.71535835
62Insidious onset (HP:0003587)2.71535835
63Thickened helices (HP:0000391)2.70891112
64Akinesia (HP:0002304)2.68083864
65Abnormal connection of the cardiac segments (HP:0011545)2.60831395
66Abnormal ventriculo-arterial connection (HP:0011563)2.60831395
67Transposition of the great arteries (HP:0001669)2.60831395
68Impaired social interactions (HP:0000735)2.60735559
69Abnormal social behavior (HP:0012433)2.60735559
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.60572827
71Abnormality of the fetal cardiovascular system (HP:0010948)2.59662740
72Abnormal umbilical cord blood vessels (HP:0011403)2.59662740
73Single umbilical artery (HP:0001195)2.59662740
74Horseshoe kidney (HP:0000085)2.59069850
75Intention tremor (HP:0002080)2.56576131
76Abnormal eating behavior (HP:0100738)2.56107770
77Scanning speech (HP:0002168)2.54165632
78Truncal ataxia (HP:0002078)2.53734552
79Abnormality of the nasal septum (HP:0000419)2.53485775
80Optic nerve hypoplasia (HP:0000609)2.47679645
81Polyphagia (HP:0002591)2.45976998
82Hemiparesis (HP:0001269)2.45261181
83Poor eye contact (HP:0000817)2.43238136
84Renal hypoplasia (HP:0000089)2.42387923
85Dysdiadochokinesis (HP:0002075)2.41689229
86Urinary urgency (HP:0000012)2.41083584
87Action tremor (HP:0002345)2.38912278
88Anencephaly (HP:0002323)2.37617848
89Hypoplasia of the ulna (HP:0003022)2.37336781
90Impaired vibration sensation in the lower limbs (HP:0002166)2.37169973
91Sensory axonal neuropathy (HP:0003390)2.35623638
92Urinary bladder sphincter dysfunction (HP:0002839)2.35341491
93Lower limb muscle weakness (HP:0007340)2.33720024
94Mutism (HP:0002300)2.31909994
95Abnormality of the labia (HP:0000058)2.31146224
96* Progressive inability to walk (HP:0002505)2.30788071
97Generalized myoclonic seizures (HP:0002123)2.30158588
98Blue irides (HP:0000635)2.30037472
99Split foot (HP:0001839)2.28214062
100Absent septum pellucidum (HP:0001331)2.27239154
101Preaxial foot polydactyly (HP:0001841)2.27207028
102Fetal akinesia sequence (HP:0001989)2.26677792
103Abnormality of binocular vision (HP:0011514)2.25706395
104Diplopia (HP:0000651)2.25706395
105Epileptiform EEG discharges (HP:0011182)2.24704199
106EEG with generalized epileptiform discharges (HP:0011198)2.24334004
107Abnormal hair whorl (HP:0010721)2.23466834
108Aplasia involving bones of the extremities (HP:0009825)2.23426339
109Aplasia involving bones of the upper limbs (HP:0009823)2.23426339
110Aplasia of the phalanges of the hand (HP:0009802)2.23426339
111Growth hormone deficiency (HP:0000824)2.21939867
112Respiratory difficulties (HP:0002880)2.21778222
113Anxiety (HP:0000739)2.21315857
114Hypsarrhythmia (HP:0002521)2.20914701
115Preaxial hand polydactyly (HP:0001177)2.19723130
116Megalencephaly (HP:0001355)2.19563200
117Methylmalonic acidemia (HP:0002912)2.15162770
118Retinal dysplasia (HP:0007973)2.13109572
119Abnormality of the septum pellucidum (HP:0007375)2.12011329
120Aplasia/Hypoplasia of the ulna (HP:0006495)2.11520982
121Gonadotropin excess (HP:0000837)2.11416335
122Depression (HP:0000716)2.09184370
123Bifid scrotum (HP:0000048)2.08919088
124Stenosis of the external auditory canal (HP:0000402)2.08621861
125Renal agenesis (HP:0000104)2.07741273
126Gait imbalance (HP:0002141)2.06839026
127Gonadal dysgenesis (HP:0000133)2.05710746
128Specific learning disability (HP:0001328)2.04720225
129Absent eyebrow (HP:0002223)2.04538129
130Anal atresia (HP:0002023)2.03830368
131Congenital primary aphakia (HP:0007707)2.02026233
132* Inability to walk (HP:0002540)2.00289717
133Abnormality of salivation (HP:0100755)1.99745516
134Triphalangeal thumb (HP:0001199)1.99726707
135Amblyopia (HP:0000646)1.97855648
136Medial flaring of the eyebrow (HP:0010747)1.96655025
137Abnormality of the pubic bones (HP:0003172)1.96471435
138Peripheral hypomyelination (HP:0007182)1.96246243
139Type II lissencephaly (HP:0007260)1.95523016
140Carpal bone hypoplasia (HP:0001498)1.95068835
141Aqueductal stenosis (HP:0002410)1.94638853
142Amyotrophic lateral sclerosis (HP:0007354)1.94094080
143Alacrima (HP:0000522)1.93552723
144Postural instability (HP:0002172)1.93343031
145Aplasia/hypoplasia of the humerus (HP:0006507)1.91409127
146Pulmonic stenosis (HP:0001642)1.90987771
147Humeroradial synostosis (HP:0003041)1.90848785
148Synostosis involving the elbow (HP:0003938)1.90848785
149Protruding tongue (HP:0010808)1.90070930
150Cleft eyelid (HP:0000625)1.89264260
151Microretrognathia (HP:0000308)1.88599785
152Neoplasm of the peripheral nervous system (HP:0100007)1.88558977
153Vaginal atresia (HP:0000148)1.87972313
154Widely spaced teeth (HP:0000687)1.87560789
155Short humerus (HP:0005792)1.87130883
156Genital tract atresia (HP:0001827)1.86627644
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85678940
158Hypoplasia of the brainstem (HP:0002365)1.85678940
159Gastroesophageal reflux (HP:0002020)1.85483414
160Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84837466
161Clumsiness (HP:0002312)1.84017647
162Nephrogenic diabetes insipidus (HP:0009806)1.83401798
163Acute necrotizing encephalopathy (HP:0006965)1.83310585
164Agitation (HP:0000713)1.82849960
165Leukodystrophy (HP:0002415)1.82082054
166Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81243558
167Rectal fistula (HP:0100590)1.79928541
168Rectovaginal fistula (HP:0000143)1.79928541
169Delayed puberty (HP:0000823)1.79922652
170Morphological abnormality of the pyramidal tract (HP:0002062)1.79410827
171Abnormality of glycolysis (HP:0004366)1.78181128
172Increased serum pyruvate (HP:0003542)1.78181128
173Esotropia (HP:0000565)1.76529181
174Spastic tetraplegia (HP:0002510)1.76354437
175Hemiplegia (HP:0002301)1.76219187
176Progressive macrocephaly (HP:0004481)1.75622104
177Abnormality of the duodenum (HP:0002246)1.75516959
178Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74841621
179Lissencephaly (HP:0001339)1.74520348
180Chorioretinal coloboma (HP:0000567)1.73366955
181Ependymoma (HP:0002888)1.73276600
182Micropenis (HP:0000054)1.70401981
183Maternal diabetes (HP:0009800)1.66177533
184Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65275927
185Dandy-Walker malformation (HP:0001305)1.63990510
186Shawl scrotum (HP:0000049)1.63538234
187Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61473957
188Aplasia/Hypoplasia of the uvula (HP:0010293)1.61442684
189Bile duct proliferation (HP:0001408)1.61384703
190Abnormal biliary tract physiology (HP:0012439)1.61384703
191Periauricular skin pits (HP:0100277)1.61327717
192Preauricular pit (HP:0004467)1.61327717
193Bilateral microphthalmos (HP:0007633)1.60963124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK28.28167160
2ACVR1B5.35896717
3MARK14.13767934
4TRIM284.01230164
5PBK3.67137143
6NTRK33.33825551
7CASK3.26712281
8STK392.85250337
9MAP3K42.84507542
10MAP2K72.79280984
11EPHA42.72559062
12OXSR12.56587099
13NTRK22.43263309
14TNIK2.37689641
15MAP3K92.28635040
16PNCK2.14356728
17TGFBR12.10190892
18MINK11.85926557
19PAK61.83032193
20CDK191.82186952
21BCR1.76975171
22NTRK11.65656013
23GRK11.64338769
24MAP3K121.63788154
25FGFR21.62441719
26MAP2K41.59391988
27FRK1.55448038
28PRPF4B1.53434530
29UHMK11.50117952
30CDK51.49074612
31PKN11.47779705
32CSNK1G21.46280544
33MAPK131.41127547
34SIK31.40560488
35MKNK21.38814081
36SGK4941.37057285
37SGK2231.37057285
38WEE11.36388219
39CSNK1G31.31635284
40DAPK21.28406167
41WNK41.28042077
42ERBB31.24948610
43MST41.23911578
44WNK11.19990449
45MAP4K21.19359955
46ICK1.18846554
47PHKG11.13738472
48PHKG21.13738472
49CAMK2B1.12447820
50LIMK11.12045408
51TYRO31.10802853
52TSSK61.09846417
53CAMK2A1.08967654
54WNK31.08042117
55MUSK1.06558071
56CSNK1A1L1.05747894
57PLK21.05532740
58PAK31.03667201
59KSR11.02686910
60AKT31.01112421
61PRKCG0.98045516
62PKN20.97988673
63CSNK1G10.96513070
64ROCK20.93778964
65NEK60.92000902
66PRKCE0.91427701
67SGK20.90436213
68FES0.89546281
69RPS6KA40.89412231
70CDK140.89354554
71MELK0.89297168
72CDK180.88701933
73DYRK20.88347936
74CDK150.87304683
75CAMK2D0.84643368
76KSR20.83382422
77INSRR0.81726691
78DYRK1A0.78712093
79GRK50.78630747
80SRPK10.74270735
81CDK11A0.74242392
82BCKDK0.74238553
83CAMK2G0.74237723
84BRD40.71791436
85BMPR1B0.68612640
86NUAK10.68492661
87STK110.68289810
88CAMK1G0.68277920
89SGK10.67856728
90FLT30.67368359
91FGR0.66788023
92PRKCH0.65398577
93TESK10.65121014
94MKNK10.64780935
95PRKD30.64658479
96STK160.64066106
97MAPKAPK50.62939369
98IRAK20.61516868
99SGK30.60876403
100CCNB10.60826025
101STK38L0.60654542
102ADRBK10.60385121
103MARK20.60083013
104CAMKK10.59591058
105SIK20.59354049
106ARAF0.58429764
107PLK40.57829005
108FYN0.55882878
109CAMK10.54948350
110PLK30.50867012
111ROCK10.49156273
112BRSK20.48543971
113FGFR10.48175468
114PRKCZ0.47995110
115NEK10.45851650
116EIF2AK30.43677027
117PRKG10.42751021
118TGFBR20.42630856
119RPS6KA30.42288931
120DAPK10.40702918
121PRKACA0.39889734
122NME10.37615821
123PTK2B0.37207415
124PRKCQ0.37180636
125ADRBK20.37167296
126EIF2AK20.36760105
127RET0.36683613
128OBSCN0.36508057
129CSNK1D0.35816805
130CDC42BPA0.35214844
131IRAK10.33557032
132MAP2K10.33554432
133PDPK10.33292308
134PRKACB0.33143368
135DYRK30.33024402
136PDK30.32997277
137PDK40.32997277
138VRK10.32797834
139CSNK1A10.32674441
140MAPK100.32046586
141PINK10.31576110
142PRKCB0.29829341
143ZAK0.27601210
144TESK20.24895862
145PLK10.23343548
146TNK20.23273723
147PRKCI0.21740161
148MAPK150.18851735
149NLK0.18270986
150CAMK40.17551828

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.82235661
2Synaptic vesicle cycle_Homo sapiens_hsa047213.11560319
3GABAergic synapse_Homo sapiens_hsa047273.09541574
4Propanoate metabolism_Homo sapiens_hsa006402.88644284
5Pyruvate metabolism_Homo sapiens_hsa006202.81368003
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.75967039
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72831595
8Morphine addiction_Homo sapiens_hsa050322.49132583
9Glutamatergic synapse_Homo sapiens_hsa047242.37604929
10Circadian entrainment_Homo sapiens_hsa047132.22580110
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20435248
12Mismatch repair_Homo sapiens_hsa034302.17855648
13Homologous recombination_Homo sapiens_hsa034402.17430633
14Collecting duct acid secretion_Homo sapiens_hsa049662.14276576
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13223798
16Basal cell carcinoma_Homo sapiens_hsa052172.00393781
17Olfactory transduction_Homo sapiens_hsa047401.94590484
18Dopaminergic synapse_Homo sapiens_hsa047281.93673675
19Serotonergic synapse_Homo sapiens_hsa047261.93646573
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92194020
21Long-term potentiation_Homo sapiens_hsa047201.80980342
22Amphetamine addiction_Homo sapiens_hsa050311.80808683
23Axon guidance_Homo sapiens_hsa043601.75498319
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75264050
25Salivary secretion_Homo sapiens_hsa049701.70861316
26Taste transduction_Homo sapiens_hsa047421.67142272
27Butanoate metabolism_Homo sapiens_hsa006501.67011972
28Long-term depression_Homo sapiens_hsa047301.65498824
29Cholinergic synapse_Homo sapiens_hsa047251.65152944
30Cocaine addiction_Homo sapiens_hsa050301.59597010
31Oxidative phosphorylation_Homo sapiens_hsa001901.59243652
32Fatty acid metabolism_Homo sapiens_hsa012121.59021388
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.58089086
34Proteasome_Homo sapiens_hsa030501.57240634
35Basal transcription factors_Homo sapiens_hsa030221.55908313
36TGF-beta signaling pathway_Homo sapiens_hsa043501.55541744
37Fanconi anemia pathway_Homo sapiens_hsa034601.53266059
38Non-homologous end-joining_Homo sapiens_hsa034501.53078713
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.52627926
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47566119
41Insulin secretion_Homo sapiens_hsa049111.46325856
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44523066
43Cardiac muscle contraction_Homo sapiens_hsa042601.44004565
44Fatty acid degradation_Homo sapiens_hsa000711.41403104
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40589102
46Peroxisome_Homo sapiens_hsa041461.40280703
47Vibrio cholerae infection_Homo sapiens_hsa051101.39628344
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38442344
49Gastric acid secretion_Homo sapiens_hsa049711.36418734
50RNA degradation_Homo sapiens_hsa030181.33786740
51Fatty acid elongation_Homo sapiens_hsa000621.31658600
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.31558272
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30859319
54Hippo signaling pathway_Homo sapiens_hsa043901.28587479
55Renin secretion_Homo sapiens_hsa049241.26408462
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23596873
57Oxytocin signaling pathway_Homo sapiens_hsa049211.22853073
58Tryptophan metabolism_Homo sapiens_hsa003801.19809919
59Protein export_Homo sapiens_hsa030601.19423848
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16421889
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15709784
62Parkinsons disease_Homo sapiens_hsa050121.15095342
63* Calcium signaling pathway_Homo sapiens_hsa040201.14586912
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14376882
65Gap junction_Homo sapiens_hsa045401.11971665
66Alzheimers disease_Homo sapiens_hsa050101.11736349
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09913160
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06913622
69Cysteine and methionine metabolism_Homo sapiens_hsa002701.06215582
70cAMP signaling pathway_Homo sapiens_hsa040240.96547272
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95622092
72* ErbB signaling pathway_Homo sapiens_hsa040120.95402716
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.94894803
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91174370
75DNA replication_Homo sapiens_hsa030300.89596774
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88990932
77Steroid biosynthesis_Homo sapiens_hsa001000.86046534
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85316262
79Selenocompound metabolism_Homo sapiens_hsa004500.83947028
80Type I diabetes mellitus_Homo sapiens_hsa049400.83504979
81Carbon metabolism_Homo sapiens_hsa012000.82557230
82GnRH signaling pathway_Homo sapiens_hsa049120.82310978
83Dilated cardiomyopathy_Homo sapiens_hsa054140.82124018
84Nucleotide excision repair_Homo sapiens_hsa034200.81116039
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.80829007
86Ether lipid metabolism_Homo sapiens_hsa005650.80790277
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79262652
88Type II diabetes mellitus_Homo sapiens_hsa049300.78641598
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.78022734
90Dorso-ventral axis formation_Homo sapiens_hsa043200.77759450
91Nitrogen metabolism_Homo sapiens_hsa009100.77716836
92Estrogen signaling pathway_Homo sapiens_hsa049150.77245406
93Melanogenesis_Homo sapiens_hsa049160.76004428
94Renal cell carcinoma_Homo sapiens_hsa052110.75497581
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75014574
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73536681
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72516015
98Circadian rhythm_Homo sapiens_hsa047100.72051372
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71249431
100RNA transport_Homo sapiens_hsa030130.71205029
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69542802
102Phototransduction_Homo sapiens_hsa047440.69375853
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69150405
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69105719
105Ras signaling pathway_Homo sapiens_hsa040140.68185768
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68116168
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.66080472
108Huntingtons disease_Homo sapiens_hsa050160.64701100
109Retinol metabolism_Homo sapiens_hsa008300.61343776
110MAPK signaling pathway_Homo sapiens_hsa040100.61238011
111Base excision repair_Homo sapiens_hsa034100.60272013
112Glioma_Homo sapiens_hsa052140.60164238
113Alcoholism_Homo sapiens_hsa050340.57249675
114Rheumatoid arthritis_Homo sapiens_hsa053230.56966144
115Choline metabolism in cancer_Homo sapiens_hsa052310.55819885
116Glucagon signaling pathway_Homo sapiens_hsa049220.55605205
117Colorectal cancer_Homo sapiens_hsa052100.55503486
118Pancreatic secretion_Homo sapiens_hsa049720.54337451
119Glutathione metabolism_Homo sapiens_hsa004800.54232964
120Caffeine metabolism_Homo sapiens_hsa002320.53018911
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52627496
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52226136
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51990814
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.50261467
125Fat digestion and absorption_Homo sapiens_hsa049750.49949825
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47703700
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46996726
128* Endocytosis_Homo sapiens_hsa041440.46829414
129Ovarian steroidogenesis_Homo sapiens_hsa049130.46798528
130Rap1 signaling pathway_Homo sapiens_hsa040150.46504822
131Wnt signaling pathway_Homo sapiens_hsa043100.45366328
132ABC transporters_Homo sapiens_hsa020100.44039331
133Chemical carcinogenesis_Homo sapiens_hsa052040.43787245
134Tight junction_Homo sapiens_hsa045300.43342071
135Thyroid hormone synthesis_Homo sapiens_hsa049180.42764393
136Sulfur metabolism_Homo sapiens_hsa009200.42531371
137Sphingolipid metabolism_Homo sapiens_hsa006000.41056983
138Oocyte meiosis_Homo sapiens_hsa041140.38958397
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38054759
140Hedgehog signaling pathway_Homo sapiens_hsa043400.37412814
141Phagosome_Homo sapiens_hsa041450.36657094
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36324817
143Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36251529
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36146554
145Fatty acid biosynthesis_Homo sapiens_hsa000610.35038708
146PPAR signaling pathway_Homo sapiens_hsa033200.34349171
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33207605
148Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31848337
149Metabolic pathways_Homo sapiens_hsa011000.31266754
150Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30767527
151Inositol phosphate metabolism_Homo sapiens_hsa005620.30707098
152Purine metabolism_Homo sapiens_hsa002300.30353551
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29493169
154Endometrial cancer_Homo sapiens_hsa052130.29152113
155beta-Alanine metabolism_Homo sapiens_hsa004100.28544497
156Vitamin B6 metabolism_Homo sapiens_hsa007500.28538153

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