ERBIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.31400213
2phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.91260368
3hypotonic response (GO:0006971)3.61601008
4detection of molecule of bacterial origin (GO:0032490)3.60195392
5nuclear pore organization (GO:0006999)3.51649558
6positive regulation of gamma-delta T cell activation (GO:0046645)3.49289402
7monoubiquitinated protein deubiquitination (GO:0035520)3.48303723
8cellular response to ethanol (GO:0071361)3.46261636
9cytoplasmic mRNA processing body assembly (GO:0033962)3.45774352
10hepatocyte apoptotic process (GO:0097284)3.34912777
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.29152693
12regulation of B cell receptor signaling pathway (GO:0050855)3.24115470
13embryonic process involved in female pregnancy (GO:0060136)3.17462997
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13022122
15pore complex assembly (GO:0046931)3.10645795
16histone H3-K36 demethylation (GO:0070544)2.95219726
17regulation of protein polyubiquitination (GO:1902914)2.94376528
18negative regulation of DNA repair (GO:0045738)2.90161204
19phospholipid translocation (GO:0045332)2.88131172
20lipid translocation (GO:0034204)2.88131172
21interkinetic nuclear migration (GO:0022027)2.87708010
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84335670
23negative regulation of cell killing (GO:0031342)2.84335670
24macrophage activation involved in immune response (GO:0002281)2.77370064
25positive regulation by symbiont of host defense response (GO:0052509)2.71033832
26modulation by symbiont of host defense response (GO:0052031)2.71033832
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71033832
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71033832
29positive regulation by organism of defense response of other organism involved in symbiotic interact2.71033832
30modulation by symbiont of host immune response (GO:0052553)2.71033832
31protein localization to endosome (GO:0036010)2.63049906
32membrane raft organization (GO:0031579)2.62223002
33microglial cell activation (GO:0001774)2.56687114
34iron ion import (GO:0097286)2.56464242
35positive T cell selection (GO:0043368)2.56427056
36B cell receptor signaling pathway (GO:0050853)2.56364507
37negative regulation of anoikis (GO:2000811)2.54862563
38positive regulation of receptor recycling (GO:0001921)2.53574258
39negative T cell selection (GO:0043383)2.52546426
40positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50774717
41negative regulation of neurotransmitter secretion (GO:0046929)2.50338240
42interleukin-6-mediated signaling pathway (GO:0070102)2.49457256
43peptidyl-threonine phosphorylation (GO:0018107)2.49238424
44peptidyl-threonine modification (GO:0018210)2.47607703
45negative thymic T cell selection (GO:0045060)2.45035795
46detection of external biotic stimulus (GO:0098581)2.44950609
47regulation of necroptotic process (GO:0060544)2.43906266
48cellular extravasation (GO:0045123)2.43509869
49definitive hemopoiesis (GO:0060216)2.42113238
50antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41765023
51regulation of RNA export from nucleus (GO:0046831)2.40865744
52nerve growth factor signaling pathway (GO:0038180)2.40150717
53cortical actin cytoskeleton organization (GO:0030866)2.39875728
54regulation of macrophage cytokine production (GO:0010935)2.39608848
55retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39388729
56regulation of gamma-delta T cell differentiation (GO:0045586)2.39162211
57regulation of interferon-beta biosynthetic process (GO:0045357)2.38488347
58regulation of nucleobase-containing compound transport (GO:0032239)2.37974725
59nucleus localization (GO:0051647)2.37970554
60establishment of protein localization to Golgi (GO:0072600)2.37158478
61regulation of gamma-delta T cell activation (GO:0046643)2.36784386
62pericardium development (GO:0060039)2.35931577
63mitotic sister chromatid cohesion (GO:0007064)2.35377547
64regulation of transforming growth factor beta2 production (GO:0032909)2.35339948
65establishment of nucleus localization (GO:0040023)2.35207642
66protein targeting to Golgi (GO:0000042)2.33845986
67histone H3-K9 demethylation (GO:0033169)2.33249964
68import into cell (GO:0098657)2.33239002
69response to interleukin-15 (GO:0070672)2.32001808
70macrophage activation (GO:0042116)2.31633851
71platelet-derived growth factor receptor signaling pathway (GO:0048008)2.31342815
72positive regulation of cellular amide metabolic process (GO:0034250)2.30160859
73embryonic camera-type eye morphogenesis (GO:0048596)2.29638915
74macroautophagy (GO:0016236)2.28946709
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.28570252
76regulation of histone H3-K27 methylation (GO:0061085)2.28036693
77Rap protein signal transduction (GO:0032486)2.27883679
78positive regulation of granulocyte differentiation (GO:0030854)2.27701683
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.27212225
80response to host (GO:0075136)2.27212225
81response to host defenses (GO:0052200)2.27212225
82cell adhesion mediated by integrin (GO:0033627)2.25732885
83histone H3-K4 trimethylation (GO:0080182)2.24438698
84early endosome to late endosome transport (GO:0045022)2.22380859
85positive regulation of macrophage cytokine production (GO:0060907)2.20022909
86neutrophil activation involved in immune response (GO:0002283)2.18842056
87response to laminar fluid shear stress (GO:0034616)2.17581974
88detection of other organism (GO:0098543)2.17371175
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.16425520
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.16151757
91antigen processing and presentation of endogenous antigen (GO:0019883)2.15346907
92regulation of establishment of cell polarity (GO:2000114)2.14177560
93regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.13686369
94positive thymic T cell selection (GO:0045059)2.13560912
95peptidyl-serine phosphorylation (GO:0018105)2.13470728
96regulation of pigment cell differentiation (GO:0050932)2.13458852
97negative regulation of inclusion body assembly (GO:0090084)2.13097006
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.12785497
99negative regulation of T-helper cell differentiation (GO:0045623)2.12785497
100establishment of protein localization to vacuole (GO:0072666)2.10411016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.71265536
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.86256143
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.03303310
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.92116724
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69413050
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67596180
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.63740090
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.40290278
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.27130398
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22140506
11GATA1_22025678_ChIP-Seq_K562_Human2.20296520
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.16951876
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.14662769
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.08747553
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07388677
16RUNX_20019798_ChIP-Seq_JUKART_Human2.01488380
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.88615025
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81231826
19IRF8_27001747_Chip-Seq_BMDM_Mouse1.78703335
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77772119
21TP53_16413492_ChIP-PET_HCT116_Human1.75214883
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.71704358
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.67800672
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67259468
25CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67081279
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66445558
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65229862
28BRD4_25478319_ChIP-Seq_HGPS_Human1.60868158
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.59858073
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59239309
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57281307
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.57180028
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56729868
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56150650
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55559596
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55559596
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54200427
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54200427
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52205330
40AHR_22903824_ChIP-Seq_MCF-7_Human1.47629455
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45470285
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42777392
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42628445
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.42549168
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.39917437
46SCL_19346495_ChIP-Seq_HPC-7_Human1.38633648
47VDR_24787735_ChIP-Seq_THP-1_Human1.37079425
48CJUN_26792858_Chip-Seq_BT549_Human1.36523586
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.31293909
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29284967
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28692162
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27042484
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25695319
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.22094627
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22024163
56MYB_26560356_Chip-Seq_TH2_Human1.20719518
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20601465
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18731299
59PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17071285
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.16342712
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15909602
62TP63_23658742_ChIP-Seq_EP156T_Human1.15728559
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14929282
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13125694
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.12183054
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12156829
67SPI1_23127762_ChIP-Seq_K562_Human1.10480144
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08483207
69STAT3_23295773_ChIP-Seq_U87_Human1.08065904
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.07565163
71MYB_26560356_Chip-Seq_TH1_Human1.06710566
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06662224
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.05207360
74PU_27001747_Chip-Seq_BMDM_Mouse1.05003313
75GATA2_19941826_ChIP-Seq_K562_Human1.04496628
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04145648
77TAF15_26573619_Chip-Seq_HEK293_Human1.03913748
78FOXM1_23109430_ChIP-Seq_U2OS_Human1.03027097
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02694697
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02584085
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02463640
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.02170855
83SMAD4_21799915_ChIP-Seq_A2780_Human1.02151630
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02006808
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99858787
86E2F1_18555785_Chip-Seq_ESCs_Mouse0.99507690
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99201794
88FOXA2_19822575_ChIP-Seq_HepG2_Human0.98887616
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96856823
90EZH2_27294783_Chip-Seq_NPCs_Mouse0.96447805
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95717463
92YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94858184
93TP53_18474530_ChIP-ChIP_U2OS_Human0.93305423
94KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93293504
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92729235
96RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92550595
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.92426841
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90836198
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90493165
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90402444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.69607190
2MP0010352_gastrointestinal_tract_polyps3.40403881
3MP0008057_abnormal_DNA_replication3.34943186
4MP0002877_abnormal_melanocyte_morpholog3.01611191
5MP0002009_preneoplasia3.00804037
6MP0003300_gastrointestinal_ulcer2.80971725
7MP0003091_abnormal_cell_migration2.63540120
8MP0003705_abnormal_hypodermis_morpholog2.46032791
9MP0003763_abnormal_thymus_physiology2.30485473
10MP0003950_abnormal_plasma_membrane2.28402009
11MP0005409_darkened_coat_color2.27457172
12MP0002166_altered_tumor_susceptibility2.25972234
13MP0001835_abnormal_antigen_presentation2.07706191
14MP0003191_abnormal_cellular_cholesterol2.05611970
15MP0003724_increased_susceptibility_to2.05390323
16MP0010234_abnormal_vibrissa_follicle2.05069393
17MP0006054_spinal_hemorrhage2.02028652
18MP0003828_pulmonary_edema1.95730670
19MP0003566_abnormal_cell_adhesion1.77436704
20MP0002396_abnormal_hematopoietic_system1.77429334
21MP0008260_abnormal_autophagy1.74922291
22MP0002006_tumorigenesis1.71123492
23MP0001958_emphysema1.70563931
24MP0003303_peritoneal_inflammation1.64714266
25MP0004808_abnormal_hematopoietic_stem1.59837918
26MP0008438_abnormal_cutaneous_collagen1.58848532
27MP0005023_abnormal_wound_healing1.57737398
28MP0003045_fibrosis1.56284661
29MP0003656_abnormal_erythrocyte_physiolo1.55002034
30MP0003690_abnormal_glial_cell1.54407031
31MP0004947_skin_inflammation1.54277336
32MP0005076_abnormal_cell_differentiation1.53808906
33MP0003183_abnormal_peptide_metabolism1.50106644
34MP0010678_abnormal_skin_adnexa1.48770600
35MP0000015_abnormal_ear_pigmentation1.46690053
36MP0004883_abnormal_blood_vessel1.45539575
37MP0000465_gastrointestinal_hemorrhage1.45447813
38MP0005464_abnormal_platelet_physiology1.45294520
39MP0001851_eye_inflammation1.41912694
40MP0005451_abnormal_body_composition1.38119919
41MP0003453_abnormal_keratinocyte_physiol1.37647214
42MP0001800_abnormal_humoral_immune1.31897279
43MP0005174_abnormal_tail_pigmentation1.25353084
44MP0005275_abnormal_skin_tensile1.25009130
45MP0003448_altered_tumor_morphology1.24221281
46MP0002332_abnormal_exercise_endurance1.23772556
47MP0005164_abnormal_response_to1.21331751
48MP0000383_abnormal_hair_follicle1.19341126
49MP0002419_abnormal_innate_immunity1.17549303
50MP0001915_intracranial_hemorrhage1.16262795
51MP0004381_abnormal_hair_follicle1.16254897
52MP0003436_decreased_susceptibility_to1.12020280
53MP0010155_abnormal_intestine_physiology1.11872252
54MP0010307_abnormal_tumor_latency1.10724385
55MP0002998_abnormal_bone_remodeling1.10561871
56MP0000685_abnormal_immune_system1.10546015
57MP0005000_abnormal_immune_tolerance1.09754980
58MP0002452_abnormal_antigen_presenting1.08353603
59MP0003221_abnormal_cardiomyocyte_apopto1.07021867
60MP0002398_abnormal_bone_marrow1.05999116
61MP0005621_abnormal_cell_physiology1.04634174
62MP0004185_abnormal_adipocyte_glucose1.04087017
63MP0000733_abnormal_muscle_development1.03237186
64MP0002723_abnormal_immune_serum1.01314683
65MP0002420_abnormal_adaptive_immunity1.00918134
66MP0003252_abnormal_bile_duct0.98095679
67MP0001819_abnormal_immune_cell0.97811256
68MP0005408_hypopigmentation0.97513993
69MP0003866_abnormal_defecation0.97486741
70MP0002405_respiratory_system_inflammati0.96428049
71MP0000427_abnormal_hair_cycle0.95987971
72MP0000371_diluted_coat_color0.95431596
73MP0003868_abnormal_feces_composition0.94603847
74MP0001879_abnormal_lymphatic_vessel0.94135329
75MP0004264_abnormal_extraembryonic_tissu0.92928069
76MP0005310_abnormal_salivary_gland0.92239769
77MP0009115_abnormal_fat_cell0.92048877
78MP0002896_abnormal_bone_mineralization0.89251719
79MP0004484_altered_response_of0.88981687
80MP0000249_abnormal_blood_vessel0.88862511
81MP0002133_abnormal_respiratory_system0.87933607
82MP0005388_respiratory_system_phenotype0.87933607
83MP0000703_abnormal_thymus_morphology0.87896447
84MP0000858_altered_metastatic_potential0.86641056
85MP0000716_abnormal_immune_system0.86053962
86MP0004130_abnormal_muscle_cell0.85566077
87MP0006082_CNS_inflammation0.83639613
88MP0000920_abnormal_myelination0.83197883
89MP0002060_abnormal_skin_morphology0.82623993
90MP0000767_abnormal_smooth_muscle0.81338304
91MP0001790_abnormal_immune_system0.79249053
92MP0005387_immune_system_phenotype0.79249053
93MP0000428_abnormal_craniofacial_morphol0.78116251
94MP0008004_abnormal_stomach_pH0.77249482
95MP0002086_abnormal_extraembryonic_tissu0.77028121
96MP0003632_abnormal_nervous_system0.76179978
97MP0002168_other_aberrant_phenotype0.75090367
98MP0009780_abnormal_chondrocyte_physiolo0.74725271
99MP0005025_abnormal_response_to0.74672403
100MP0003172_abnormal_lysosome_physiology0.74186718

Predicted human phenotypes

RankGene SetZ-score
1Subacute progressive viral hepatitis (HP:0006572)3.68646951
2Osteolytic defects of the phalanges of the hand (HP:0009771)3.38226805
3Osteolytic defects of the hand bones (HP:0009699)3.38226805
4Papillary thyroid carcinoma (HP:0002895)3.34913512
5T lymphocytopenia (HP:0005403)3.26820803
6Arterial tortuosity (HP:0005116)3.23342046
7Vascular tortuosity (HP:0004948)3.00797874
8Absent frontal sinuses (HP:0002688)2.93072881
9Abnormality of T cell number (HP:0011839)2.90964703
10Eczematoid dermatitis (HP:0000976)2.71410571
11Syringomyelia (HP:0003396)2.69825382
12Spinal cord lesions (HP:0100561)2.69825382
13Aortic aneurysm (HP:0004942)2.65539029
14Aortic dissection (HP:0002647)2.49035128
15Insidious onset (HP:0003587)2.42180897
16Termporal pattern (HP:0011008)2.42180897
17Spontaneous hematomas (HP:0007420)2.39507999
18Peritonitis (HP:0002586)2.37242665
19Overgrowth (HP:0001548)2.31115902
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28632922
21Deep philtrum (HP:0002002)2.26921391
22Scanning speech (HP:0002168)2.26685399
23Recurrent bacterial skin infections (HP:0005406)2.26508474
24Viral hepatitis (HP:0006562)2.23735612
25Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.21728658
26Gingivitis (HP:0000230)2.21418187
27Heterotopia (HP:0002282)2.20943419
28Ankyloglossia (HP:0010296)2.17511792
29Acute myeloid leukemia (HP:0004808)2.16474266
30Spondylolisthesis (HP:0003302)2.14061370
31Subaortic stenosis (HP:0001682)2.10260531
32Abnormality of the left ventricular outflow tract (HP:0011103)2.10260531
33Gingival bleeding (HP:0000225)2.08850638
34Transitional cell carcinoma of the bladder (HP:0006740)2.07410633
35Increased mean platelet volume (HP:0011877)2.06942557
36Papilledema (HP:0001085)2.05984872
37Recurrent abscess formation (HP:0002722)2.05865801
38Vertebral arch anomaly (HP:0008438)2.04910527
39Abnormality of the fingertips (HP:0001211)2.04637717
40Abnormal platelet volume (HP:0011876)2.04612058
41Bladder neoplasm (HP:0009725)2.02590364
42Bladder carcinoma (HP:0002862)2.02590364
43Relative macrocephaly (HP:0004482)2.02382246
44Curly hair (HP:0002212)2.02230634
45Periodontitis (HP:0000704)1.96665730
46Narrow palate (HP:0000189)1.94721679
47Cubitus valgus (HP:0002967)1.94620245
48Dislocated radial head (HP:0003083)1.93949836
49Large earlobe (HP:0009748)1.93464052
50Dilatation of the ascending aorta (HP:0005111)1.93446182
51Thick nail (HP:0001805)1.92732107
52Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92326168
53Coarse hair (HP:0002208)1.91046578
54Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.90228705
55Conjunctival telangiectasia (HP:0000524)1.89428920
56Abnormality of oral frenula (HP:0000190)1.88475348
57Thyroid carcinoma (HP:0002890)1.87831397
58Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85179906
59Mitral valve prolapse (HP:0001634)1.85071373
60Thoracolumbar scoliosis (HP:0002944)1.84534589
61Menstrual irregularities (HP:0000858)1.83895819
62Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82955681
63Abnormality of the frontal sinuses (HP:0002687)1.82615603
64Atrophic scars (HP:0001075)1.77554973
65Chronic diarrhea (HP:0002028)1.77260170
66Hyporeflexia of lower limbs (HP:0002600)1.77158134
67Cystic hygroma (HP:0000476)1.76662531
68Slow saccadic eye movements (HP:0000514)1.76182877
69Wormian bones (HP:0002645)1.76121875
70Neoplasm of the tracheobronchial system (HP:0100552)1.75705792
71Uterine leiomyosarcoma (HP:0002891)1.74502153
72Leiomyosarcoma (HP:0100243)1.74502153
73Truncal obesity (HP:0001956)1.74162131
74Cellulitis (HP:0100658)1.74033887
75Abnormality of the radial head (HP:0003995)1.73605535
76Difficulty running (HP:0009046)1.73413285
77Sandal gap (HP:0001852)1.71158956
78Flat acetabular roof (HP:0003180)1.69549177
79Chest pain (HP:0100749)1.69196654
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.68684834
81Short chin (HP:0000331)1.68542830
82Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68036027
83Protrusio acetabuli (HP:0003179)1.68020739
84Arterial thrombosis (HP:0004420)1.67347325
85Macroorchidism (HP:0000053)1.67012003
86Fatigue (HP:0012378)1.66062959
87Micronodular cirrhosis (HP:0001413)1.64780779
88Low anterior hairline (HP:0000294)1.64493498
89Abnormal glucose tolerance (HP:0001952)1.64144609
90Colitis (HP:0002583)1.64062317
91Orchitis (HP:0100796)1.63752711
92Hypoplasia of the iris (HP:0007676)1.63585591
93Glucose intolerance (HP:0000833)1.63421915
94Autoimmune hemolytic anemia (HP:0001890)1.63339041
95Mitral stenosis (HP:0001718)1.63158055
96Recurrent viral infections (HP:0004429)1.61644911
97Volvulus (HP:0002580)1.61122043
98Optic neuritis (HP:0100653)1.61089765
99Retrobulbar optic neuritis (HP:0100654)1.61089765
100Gastrointestinal infarctions (HP:0005244)1.60521747

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT32.41620350
2BMPR22.35472718
3MAP3K22.35071343
4JAK12.16564726
5NEK92.11083246
6CDK122.02993280
7FGFR31.87195662
8BRD41.83292991
9MAP3K141.78444386
10RIPK41.76261110
11PDGFRB1.71720509
12BLK1.71256409
13PDGFRA1.68994172
14LATS11.68614137
15CSK1.68578420
16SGK31.68149669
17WNK11.66178135
18SCYL21.64391580
19PIK3CG1.64192683
20MAP3K101.59875540
21MELK1.59442069
22ACVR1B1.59129244
23YES11.55768892
24KSR11.53974452
25TRPM71.53211631
26SGK21.52033980
27PRPF4B1.50348115
28MST1R1.44628652
29TTN1.41786015
30NEK61.41707994
31TYK21.39481547
32CDK61.36430924
33CAMKK21.20791153
34STK391.20022335
35STK241.16516337
36STK31.15516395
37KSR21.12839768
38JAK31.12672464
39MAP3K61.11695648
40NLK1.07648264
41STK101.07083512
42ZAP701.06261360
43BRSK21.06196105
44MET1.04090583
45HCK1.03230344
46FGR1.03023499
47TEC1.01690840
48BTK0.98251064
49TGFBR20.98180432
50JAK20.97840814
51RET0.94297647
52IRAK40.94124482
53ERBB30.90844112
54MAP2K30.89400399
55MAP3K130.87756450
56CAMK1G0.86448674
57RIPK10.85983478
58FGFR40.80795289
59SYK0.79106582
60STK380.78579466
61MST40.78184191
62PTK2B0.76166384
63IRAK10.74662088
64FRK0.69783383
65STK40.67347878
66PKN20.66610088
67IKBKE0.65893958
68RAF10.62947371
69CSF1R0.61851023
70IRAK20.60756753
71SGK2230.60571379
72SGK4940.60571379
73MOS0.59275848
74PDK10.58240195
75MAPK70.57637482
76MTOR0.57016174
77ITK0.56947155
78EIF2AK30.56575523
79DMPK0.56443511
80LCK0.55352569
81CAMK1D0.54838171
82ICK0.54523519
83PLK20.52959775
84PAK20.52671329
85STK38L0.52072107
86SGK10.51242981
87MAP3K10.49748816
88TNIK0.49394044
89PIK3CA0.48850112
90MAPK110.48255179
91MARK20.47870552
92MAPK100.47665702
93TXK0.47138081
94MARK30.46033604
95MAP3K30.45816180
96FER0.44354387
97FGFR10.44288800
98GRK60.43796609
99EPHB10.43135002
100FES0.42826960

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-small cell lung cancer_Homo sapiens_hsa052231.83611037
2B cell receptor signaling pathway_Homo sapiens_hsa046621.81645352
3Pancreatic cancer_Homo sapiens_hsa052121.79306861
4Chronic myeloid leukemia_Homo sapiens_hsa052201.78568943
5Dorso-ventral axis formation_Homo sapiens_hsa043201.66906855
6Renal cell carcinoma_Homo sapiens_hsa052111.61563015
7Endometrial cancer_Homo sapiens_hsa052131.54408969
8Adherens junction_Homo sapiens_hsa045201.53838863
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53360933
10Osteoclast differentiation_Homo sapiens_hsa043801.52489954
11Platelet activation_Homo sapiens_hsa046111.47019643
12T cell receptor signaling pathway_Homo sapiens_hsa046601.43845443
13Leishmaniasis_Homo sapiens_hsa051401.37342323
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.37063798
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33776723
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29704913
17Measles_Homo sapiens_hsa051621.29506468
18Glioma_Homo sapiens_hsa052141.28726955
19Acute myeloid leukemia_Homo sapiens_hsa052211.28416913
20Prostate cancer_Homo sapiens_hsa052151.28166279
21Focal adhesion_Homo sapiens_hsa045101.27585520
22Inositol phosphate metabolism_Homo sapiens_hsa005621.27356375
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26048005
24MicroRNAs in cancer_Homo sapiens_hsa052061.26028128
25Small cell lung cancer_Homo sapiens_hsa052221.24582355
26Proteoglycans in cancer_Homo sapiens_hsa052051.24387311
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23497036
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.22470919
29Toxoplasmosis_Homo sapiens_hsa051451.22345159
30FoxO signaling pathway_Homo sapiens_hsa040681.21674833
31Thyroid cancer_Homo sapiens_hsa052161.21567133
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20030536
33ErbB signaling pathway_Homo sapiens_hsa040121.19129468
34Hepatitis B_Homo sapiens_hsa051611.18228722
35Colorectal cancer_Homo sapiens_hsa052101.17975293
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14957388
37Prolactin signaling pathway_Homo sapiens_hsa049171.14001130
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.11609544
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.10589128
40mTOR signaling pathway_Homo sapiens_hsa041501.09247044
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08924966
42TNF signaling pathway_Homo sapiens_hsa046681.05347189
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05139221
44Chemokine signaling pathway_Homo sapiens_hsa040621.02004205
45Long-term potentiation_Homo sapiens_hsa047201.01325233
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01293741
47Influenza A_Homo sapiens_hsa051641.01094871
48Amoebiasis_Homo sapiens_hsa051461.00466839
49Tuberculosis_Homo sapiens_hsa051521.00152350
50Choline metabolism in cancer_Homo sapiens_hsa052310.98743068
51Hepatitis C_Homo sapiens_hsa051600.97865489
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.97827218
53VEGF signaling pathway_Homo sapiens_hsa043700.97384746
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.96271778
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.93249564
56Malaria_Homo sapiens_hsa051440.91570158
57Viral carcinogenesis_Homo sapiens_hsa052030.91355974
58GnRH signaling pathway_Homo sapiens_hsa049120.84178085
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83822530
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83146612
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79738491
62Apoptosis_Homo sapiens_hsa042100.78122648
63Estrogen signaling pathway_Homo sapiens_hsa049150.77462028
64Hematopoietic cell lineage_Homo sapiens_hsa046400.76357770
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76181432
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75839996
67ECM-receptor interaction_Homo sapiens_hsa045120.74831166
68Shigellosis_Homo sapiens_hsa051310.74571104
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73644155
70Rap1 signaling pathway_Homo sapiens_hsa040150.70288286
71Endocytosis_Homo sapiens_hsa041440.70097844
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69831334
73Staphylococcus aureus infection_Homo sapiens_hsa051500.69668673
74Pathways in cancer_Homo sapiens_hsa052000.69636892
75Insulin resistance_Homo sapiens_hsa049310.69587556
76Legionellosis_Homo sapiens_hsa051340.68490246
77HIF-1 signaling pathway_Homo sapiens_hsa040660.68048653
78Viral myocarditis_Homo sapiens_hsa054160.67551938
79Gap junction_Homo sapiens_hsa045400.66396526
80Melanoma_Homo sapiens_hsa052180.65588874
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65233832
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64400649
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63453597
84Herpes simplex infection_Homo sapiens_hsa051680.63117281
85Notch signaling pathway_Homo sapiens_hsa043300.61629624
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.61235590
87Fatty acid biosynthesis_Homo sapiens_hsa000610.60088295
88Salmonella infection_Homo sapiens_hsa051320.60060844
89MAPK signaling pathway_Homo sapiens_hsa040100.59785158
90Circadian rhythm_Homo sapiens_hsa047100.59336797
91Bladder cancer_Homo sapiens_hsa052190.59157515
92Insulin signaling pathway_Homo sapiens_hsa049100.59096544
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58948220
94Renin-angiotensin system_Homo sapiens_hsa046140.56196838
95Ras signaling pathway_Homo sapiens_hsa040140.56109751
96Renin secretion_Homo sapiens_hsa049240.55504370
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53548924
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.51436681
99TGF-beta signaling pathway_Homo sapiens_hsa043500.51284275
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49825099

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »