ERC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13) in thyroid papillary carcinoma. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.55228395
2vocalization behavior (GO:0071625)4.22246847
3central nervous system projection neuron axonogenesis (GO:0021952)3.98565523
4layer formation in cerebral cortex (GO:0021819)3.78654621
5response to pheromone (GO:0019236)3.77322342
6dendrite morphogenesis (GO:0048813)3.67494257
7nucleobase catabolic process (GO:0046113)3.60292802
8negative regulation of catenin import into nucleus (GO:0035414)3.56097678
9regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55573443
10cell migration in hindbrain (GO:0021535)3.54020197
11axonal fasciculation (GO:0007413)3.44075344
12dendritic spine morphogenesis (GO:0060997)3.41262995
13locomotory exploration behavior (GO:0035641)3.37228476
14neuron recognition (GO:0008038)3.34437176
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33617799
16postsynaptic membrane organization (GO:0001941)3.32352070
17neuron cell-cell adhesion (GO:0007158)3.26812618
18central nervous system neuron axonogenesis (GO:0021955)3.18792882
19protein localization to synapse (GO:0035418)3.17611657
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.15044084
21positive regulation of dendritic spine morphogenesis (GO:0061003)3.06604771
22axon extension (GO:0048675)3.00768110
23synaptic vesicle maturation (GO:0016188)3.00765546
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.00253540
25synaptic vesicle docking involved in exocytosis (GO:0016081)2.98728166
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98627943
27cell communication by electrical coupling (GO:0010644)2.92896488
28positive regulation of synapse maturation (GO:0090129)2.91200376
29cerebral cortex radially oriented cell migration (GO:0021799)2.90353413
30regulation of glutamate receptor signaling pathway (GO:1900449)2.89795612
31establishment of protein localization to Golgi (GO:0072600)2.89204429
32exploration behavior (GO:0035640)2.88707272
33glutamate secretion (GO:0014047)2.88688761
34cerebellar Purkinje cell differentiation (GO:0021702)2.83115414
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82069714
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.80181589
37glutamate receptor signaling pathway (GO:0007215)2.76354087
38auditory behavior (GO:0031223)2.75189909
39cerebellar granule cell differentiation (GO:0021707)2.74739679
40neuronal ion channel clustering (GO:0045161)2.73931844
41cell communication involved in cardiac conduction (GO:0086065)2.73770441
42regulation of axon extension involved in axon guidance (GO:0048841)2.71917573
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.71384130
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.70492145
45hemidesmosome assembly (GO:0031581)2.66959310
46establishment of nucleus localization (GO:0040023)2.66326120
47synaptic transmission, glutamatergic (GO:0035249)2.65956444
48neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65215598
49positive regulation of neurological system process (GO:0031646)2.64880202
50spinal cord development (GO:0021510)2.63146821
51retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61934381
52protein targeting to Golgi (GO:0000042)2.60453371
53regulation of axon guidance (GO:1902667)2.60349100
54mitochondrion transport along microtubule (GO:0047497)2.60246512
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.60246512
56plasma membrane repair (GO:0001778)2.57305585
57homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.57067696
58negative regulation of keratinocyte proliferation (GO:0010839)2.55993164
59nucleus localization (GO:0051647)2.55855841
60lymphangiogenesis (GO:0001946)2.55651391
61regulation of hippo signaling (GO:0035330)2.55199435
62limb bud formation (GO:0060174)2.54498533
63neuron projection extension (GO:1990138)2.53847021
64regulation of synapse assembly (GO:0051963)2.52658289
65regulation of axon regeneration (GO:0048679)2.50960400
66regulation of neuron projection regeneration (GO:0070570)2.50960400
67positive regulation of axon extension (GO:0045773)2.50607688
68regulation of synapse maturation (GO:0090128)2.50011616
69neurotransmitter-gated ion channel clustering (GO:0072578)2.49934111
70embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48259121
71negative regulation of hormone biosynthetic process (GO:0032353)2.48130363
72regulation of dendritic spine morphogenesis (GO:0061001)2.46051135
73pericardium development (GO:0060039)2.45784861
74presynaptic membrane organization (GO:0097090)2.44654062
75insulin-like growth factor receptor signaling pathway (GO:0048009)2.43062006
76synapse assembly (GO:0007416)2.42403874
77innervation (GO:0060384)2.41223855
78head development (GO:0060322)2.41159978
79dermatan sulfate biosynthetic process (GO:0030208)2.38845214
80vesicle transport along microtubule (GO:0047496)2.37129607
81lateral sprouting from an epithelium (GO:0060601)2.36063758
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35402517
83mesenchymal-epithelial cell signaling (GO:0060638)2.35302098
84regulation of neuron migration (GO:2001222)2.34940579
85regulation of synapse organization (GO:0050807)2.34693454
86positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.34524504
87regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.34432323
88presynaptic membrane assembly (GO:0097105)2.34275246
89long-term memory (GO:0007616)2.33329186
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33191352
91proline transport (GO:0015824)2.32479847
92gamma-aminobutyric acid transport (GO:0015812)2.31946158
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.31914645
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.31563111
95axon extension involved in axon guidance (GO:0048846)2.31563111
96protein localization to Golgi apparatus (GO:0034067)2.30698847
97positive regulation of dendrite morphogenesis (GO:0050775)2.30642388
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.30067649
99cerebral cortex cell migration (GO:0021795)2.29992577
100peripheral nervous system axon ensheathment (GO:0032292)2.29783912
101myelination in peripheral nervous system (GO:0022011)2.29783912
102positive regulation of synapse assembly (GO:0051965)2.29737569
103calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29409729
104response to auditory stimulus (GO:0010996)2.29226254
105negative chemotaxis (GO:0050919)2.28911961
106artery development (GO:0060840)2.28316389
107semaphorin-plexin signaling pathway (GO:0071526)2.28122096
108smooth muscle tissue development (GO:0048745)2.27465838
109regulation of synapse structural plasticity (GO:0051823)2.27408700
110cell differentiation in hindbrain (GO:0021533)2.26766605
111cochlea development (GO:0090102)2.26292137
112establishment of mitochondrion localization (GO:0051654)2.26138969
113synaptic vesicle exocytosis (GO:0016079)2.25723804
114neuron projection morphogenesis (GO:0048812)2.25406203
115interkinetic nuclear migration (GO:0022027)2.25051851
116positive regulation of dendritic spine development (GO:0060999)2.25050680
117calcium ion import (GO:0070509)2.24856194
118regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24434140
119dendritic spine organization (GO:0097061)2.24221408
120cardiac myofibril assembly (GO:0055003)2.23859498
121atrial cardiac muscle cell action potential (GO:0086014)2.23730963
122organelle transport along microtubule (GO:0072384)2.23401636
123appendage development (GO:0048736)2.23250768
124limb development (GO:0060173)2.23250768
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.23021393
126myelin assembly (GO:0032288)2.22618648
127negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.22220192
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.22220192
129regulation of translation, ncRNA-mediated (GO:0045974)2.22220192
130urinary tract smooth muscle contraction (GO:0014848)2.20533440
131negative regulation of axon extension involved in axon guidance (GO:0048843)2.19444546
132cAMP catabolic process (GO:0006198)2.19358763
133cyclic nucleotide catabolic process (GO:0009214)2.15493140
134startle response (GO:0001964)2.13892535
135regulation of transmission of nerve impulse (GO:0051969)2.13098916
136glomerular visceral epithelial cell development (GO:0072015)2.10231199
137negative regulation of axon guidance (GO:1902668)2.08900310
138cranial nerve morphogenesis (GO:0021602)2.06610587
139dermatan sulfate metabolic process (GO:0030205)2.05521159
140inner ear receptor cell development (GO:0060119)2.03635885
141spinal cord motor neuron differentiation (GO:0021522)2.03356133
142regulation of respiratory system process (GO:0044065)2.03076157
143lipid translocation (GO:0034204)2.02514401
144phospholipid translocation (GO:0045332)2.02514401
145myoblast fusion (GO:0007520)1.99233712
146cranial nerve structural organization (GO:0021604)1.97734438
147membrane depolarization during action potential (GO:0086010)1.96535443
148sequestering of extracellular ligand from receptor (GO:0035581)1.96150721
149collagen fibril organization (GO:0030199)1.94100987
150embryonic foregut morphogenesis (GO:0048617)1.93571255
151mechanosensory behavior (GO:0007638)1.93565985
152regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.93049453
153righting reflex (GO:0060013)1.93026482
154cytoplasmic mRNA processing body assembly (GO:0033962)1.92550000
155smooth muscle contraction (GO:0006939)1.91749014
156neuron maturation (GO:0042551)1.91203593
157negative regulation of hormone metabolic process (GO:0032351)1.90774946
158regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.90150122
159regulation of protein polyubiquitination (GO:1902914)1.89604434
160suckling behavior (GO:0001967)1.89313491
161macroautophagy (GO:0016236)1.89168276

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63966122
2GBX2_23144817_ChIP-Seq_PC3_Human3.36536537
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03246183
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.52217077
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44526323
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34156771
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.30473097
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29654096
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24699121
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24699121
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.22379114
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13512964
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03936507
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01124854
15DROSHA_22980978_ChIP-Seq_HELA_Human2.00655804
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97985637
17RNF2_27304074_Chip-Seq_ESCs_Mouse1.93933673
18AR_21572438_ChIP-Seq_LNCaP_Human1.85320619
19* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81886146
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78992656
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76924989
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.75437057
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.71067115
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69739187
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69040343
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.65561309
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.63907445
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62723897
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61266840
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60419282
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57536315
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57514871
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.56528478
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55571999
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55146066
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52993565
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.52931208
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.51339977
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.49964595
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48297229
41AHR_22903824_ChIP-Seq_MCF-7_Human1.48117274
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47000034
43REST_21632747_ChIP-Seq_MESCs_Mouse1.46827338
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.44724496
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44579079
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43977125
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43770503
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43197431
49CJUN_26792858_Chip-Seq_BT549_Human1.42651918
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.40830908
51P300_19829295_ChIP-Seq_ESCs_Human1.39581405
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37602171
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37541634
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.36861131
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35916622
56* STAT3_23295773_ChIP-Seq_U87_Human1.34419943
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31451496
58* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30151361
59ZNF274_21170338_ChIP-Seq_K562_Hela1.29405770
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.28834274
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28468840
62TP53_16413492_ChIP-PET_HCT116_Human1.28367100
63AR_19668381_ChIP-Seq_PC3_Human1.27834549
64TP53_18474530_ChIP-ChIP_U2OS_Human1.27298320
65BRD4_25478319_ChIP-Seq_HGPS_Human1.26561032
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.26547305
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25952802
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25433321
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24337968
70TAF15_26573619_Chip-Seq_HEK293_Human1.22567065
71NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22543489
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22543489
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22024869
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22024869
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21436473
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21009976
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.20831725
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20321483
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20142607
80CBP_20019798_ChIP-Seq_JUKART_Human1.20142607
81IGF1R_20145208_ChIP-Seq_DFB_Human1.20064689
82TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19803401
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18641158
84* AR_25329375_ChIP-Seq_VCAP_Human1.18303181
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.17484480
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17276821
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17141798
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16541422
89* TCF4_23295773_ChIP-Seq_U87_Human1.15909487
90KDM2B_26808549_Chip-Seq_REH_Human1.15670110
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14976009
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.13613033
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12943775
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.12768067
95ISL1_27105846_Chip-Seq_CPCs_Mouse1.11738416
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08682613
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08552214
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.08504036
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08406419
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07886880
101TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07793247
102EWS_26573619_Chip-Seq_HEK293_Human1.07602442
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07489653
104TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06652876
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06417485
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.05836753
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05350382
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05278201
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04003872
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.03359591
111RNF2_27304074_Chip-Seq_NSC_Mouse1.01692708
112TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00171755
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00057519
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99955122
115RARB_27405468_Chip-Seq_BRAIN_Mouse0.99311043
116REST_18959480_ChIP-ChIP_MESCs_Mouse0.98760834
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98048175
118UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96613541
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.95160021
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93131530
121FUS_26573619_Chip-Seq_HEK293_Human0.93098219
122BCAT_22108803_ChIP-Seq_LS180_Human0.92621244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.81783219
2MP0004859_abnormal_synaptic_plasticity3.52396558
3MP0004270_analgesia2.42080794
4MP0008438_abnormal_cutaneous_collagen2.31059038
5MP0000778_abnormal_nervous_system2.24885841
6MP0003635_abnormal_synaptic_transmissio2.18917751
7MP0003950_abnormal_plasma_membrane2.14907150
8MP0002102_abnormal_ear_morphology2.10369507
9MP0009780_abnormal_chondrocyte_physiolo2.06965162
10MP0005187_abnormal_penis_morphology1.99062988
11MP0005275_abnormal_skin_tensile1.98185203
12MP0002938_white_spotting1.97975425
13MP0010368_abnormal_lymphatic_system1.97781818
14MP0005248_abnormal_Harderian_gland1.93097428
15MP0002063_abnormal_learning/memory/cond1.90360405
16MP0000751_myopathy1.86589822
17MP0002735_abnormal_chemical_nociception1.84608905
18MP0002184_abnormal_innervation1.81619559
19MP0001299_abnormal_eye_distance/1.80848987
20MP0003385_abnormal_body_wall1.79145807
21MP0004885_abnormal_endolymph1.77977686
22MP0003880_abnormal_central_pattern1.76899946
23MP0002734_abnormal_mechanical_nocicepti1.65830560
24MP0009250_abnormal_appendicular_skeleto1.60194153
25MP0006276_abnormal_autonomic_nervous1.56989892
26MP0009046_muscle_twitch1.55848397
27MP0000383_abnormal_hair_follicle1.55589028
28MP0001879_abnormal_lymphatic_vessel1.55065350
29MP0002572_abnormal_emotion/affect_behav1.54829547
30MP0005423_abnormal_somatic_nervous1.54639726
31MP0005503_abnormal_tendon_morphology1.54526076
32MP0003136_yellow_coat_color1.52469320
33MP0003787_abnormal_imprinting1.50798668
34MP0001486_abnormal_startle_reflex1.47973058
35MP0003122_maternal_imprinting1.46257947
36MP0002837_dystrophic_cardiac_calcinosis1.45226665
37MP0000579_abnormal_nail_morphology1.44379220
38MP0005174_abnormal_tail_pigmentation1.44279895
39MP0001968_abnormal_touch/_nociception1.40161238
40MP0009745_abnormal_behavioral_response1.39795746
41MP0002557_abnormal_social/conspecific_i1.39651446
42MP0001440_abnormal_grooming_behavior1.37824135
43MP0004215_abnormal_myocardial_fiber1.37199011
44MP0005409_darkened_coat_color1.35292126
45MP0000013_abnormal_adipose_tissue1.31162705
46MP0005623_abnormal_meninges_morphology1.29976245
47MP0003935_abnormal_craniofacial_develop1.29882202
48MP0010386_abnormal_urinary_bladder1.29331115
49MP0010678_abnormal_skin_adnexa1.27025070
50MP0003755_abnormal_palate_morphology1.26430159
51MP0003937_abnormal_limbs/digits/tail_de1.25649392
52MP0000955_abnormal_spinal_cord1.25247286
53MP0002067_abnormal_sensory_capabilities1.21971362
54MP0008057_abnormal_DNA_replication1.21001235
55MP0001188_hyperpigmentation1.20266865
56MP0004858_abnormal_nervous_system1.19356274
57MP0004145_abnormal_muscle_electrophysio1.15391151
58MP0000427_abnormal_hair_cycle1.15137885
59MP0006292_abnormal_olfactory_placode1.14958362
60MP0000566_synostosis1.14596340
61MP0003137_abnormal_impulse_conducting1.12901267
62MP0003861_abnormal_nervous_system1.12752293
63MP0003119_abnormal_digestive_system1.12482309
64MP0002249_abnormal_larynx_morphology1.12265616
65MP0005377_hearing/vestibular/ear_phenot1.11453492
66MP0003878_abnormal_ear_physiology1.11453492
67MP0002733_abnormal_thermal_nociception1.10610036
68MP0002116_abnormal_craniofacial_bone1.10578363
69MP0004811_abnormal_neuron_physiology1.10151816
70MP0003890_abnormal_embryonic-extraembry1.10031965
71MP0005257_abnormal_intraocular_pressure1.08350008
72MP0003646_muscle_fatigue1.08296465
73MP0002234_abnormal_pharynx_morphology1.07032499
74MP0000537_abnormal_urethra_morphology1.05519697
75MP0002152_abnormal_brain_morphology1.05159042
76MP0000516_abnormal_urinary_system1.04788297
77MP0005367_renal/urinary_system_phenotyp1.04788297
78MP0002882_abnormal_neuron_morphology1.04748131
79MP0002064_seizures1.04554629
80MP0004134_abnormal_chest_morphology1.03968825
81MP0003942_abnormal_urinary_system1.03823824
82MP0001984_abnormal_olfaction1.03639148
83MP0004085_abnormal_heartbeat1.03066983
84MP0003045_fibrosis1.02583928
85MP0002896_abnormal_bone_mineralization1.02036803
86MP0002233_abnormal_nose_morphology1.01906728
87MP0004233_abnormal_muscle_weight1.01055020
88MP0003283_abnormal_digestive_organ0.99424458
89MP0009053_abnormal_anal_canal0.98659363
90MP0000049_abnormal_middle_ear0.98294746
91MP0002909_abnormal_adrenal_gland0.97710603
92MP0003121_genomic_imprinting0.96956195
93MP0002108_abnormal_muscle_morphology0.95790300
94MP0005645_abnormal_hypothalamus_physiol0.94355421
95MP0000015_abnormal_ear_pigmentation0.94351668
96MP0001958_emphysema0.94345325
97MP0004133_heterotaxia0.94183255
98MP0000631_abnormal_neuroendocrine_gland0.91712130
99MP0010352_gastrointestinal_tract_polyps0.91702583
100MP0000534_abnormal_ureter_morphology0.91219316
101MP0002089_abnormal_postnatal_growth/wei0.90788190
102MP0005171_absent_coat_pigmentation0.90611026
103MP0002177_abnormal_outer_ear0.90553218
104MP0002272_abnormal_nervous_system0.90461143
105MP0000762_abnormal_tongue_morphology0.90386608
106MP0004272_abnormal_basement_membrane0.88887837
107MP0003705_abnormal_hypodermis_morpholog0.88883989
108MP0000372_irregular_coat_pigmentation0.88876589
109MP0005508_abnormal_skeleton_morphology0.88581051
110MP0000462_abnormal_digestive_system0.88434879
111MP0003879_abnormal_hair_cell0.88012194
112MP0004043_abnormal_pH_regulation0.87903242
113MP0006138_congestive_heart_failure0.87749415
114MP0002736_abnormal_nociception_after0.87611360
115MP0000647_abnormal_sebaceous_gland0.87393723
116MP0003941_abnormal_skin_development0.86973060
117MP0002168_other_aberrant_phenotype0.86299789
118MP0000003_abnormal_adipose_tissue0.86088020
119MP0005551_abnormal_eye_electrophysiolog0.85836038
120MP0000432_abnormal_head_morphology0.85659268
121MP0010030_abnormal_orbit_morphology0.85407870
122MP0000428_abnormal_craniofacial_morphol0.84054707
123MP0004924_abnormal_behavior0.83629943
124MP0005386_behavior/neurological_phenoty0.83629943
125MP0001502_abnormal_circadian_rhythm0.82889094
126MP0002081_perinatal_lethality0.82674813
127MP0001177_atelectasis0.82626980
128MP0004084_abnormal_cardiac_muscle0.82584848
129MP0008775_abnormal_heart_ventricle0.79982039
130MP0008569_lethality_at_weaning0.79171084
131MP0004782_abnormal_surfactant_physiolog0.78474658
132MP0003632_abnormal_nervous_system0.78337947
133MP0003115_abnormal_respiratory_system0.78045232
134MP0000538_abnormal_urinary_bladder0.77905702
135MP0003566_abnormal_cell_adhesion0.77708072
136MP0002295_abnormal_pulmonary_circulatio0.74376100

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)3.54659169
2Genetic anticipation (HP:0003743)3.19610622
3Hepatoblastoma (HP:0002884)3.11728374
4Action tremor (HP:0002345)3.05147767
5Shallow orbits (HP:0000586)2.75258035
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74861507
7Short 4th metacarpal (HP:0010044)2.74861507
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.67001314
9Abnormality of the nasal septum (HP:0000419)2.60674882
10Febrile seizures (HP:0002373)2.52832757
11Focal seizures (HP:0007359)2.50383671
12Atrophic scars (HP:0001075)2.45452740
13Overgrowth (HP:0001548)2.45185285
14Midline defect of the nose (HP:0004122)2.44142310
15Hyperventilation (HP:0002883)2.37283204
16Drooling (HP:0002307)2.36610282
17Excessive salivation (HP:0003781)2.36610282
18Hypoplastic ischia (HP:0003175)2.34043211
19Focal motor seizures (HP:0011153)2.23078647
20Aqueductal stenosis (HP:0002410)2.18051527
21Myokymia (HP:0002411)2.17806618
22Abnormality of the ischium (HP:0003174)2.16262072
23Follicular hyperkeratosis (HP:0007502)2.14707558
24Elfin facies (HP:0004428)2.13994907
25Abnormality of the 4th metacarpal (HP:0010012)2.13208078
26Broad-based gait (HP:0002136)2.11527381
27Truncal obesity (HP:0001956)2.10562124
28Abnormality of the sella turcica (HP:0002679)2.10239480
29Turricephaly (HP:0000262)2.09659974
30Epileptic encephalopathy (HP:0200134)2.07737979
31Lower limb amyotrophy (HP:0007210)2.05894264
32Heterotopia (HP:0002282)2.03344859
33Protrusio acetabuli (HP:0003179)2.02809220
34Soft skin (HP:0000977)2.01455886
35Obstructive sleep apnea (HP:0002870)2.00238641
36Laryngomalacia (HP:0001601)1.99849508
37Abnormality of the diencephalon (HP:0010662)1.99568002
38Fair hair (HP:0002286)1.98332391
39Papillary thyroid carcinoma (HP:0002895)1.97748163
40Neoplasm of the adrenal cortex (HP:0100641)1.97495682
41Renovascular hypertension (HP:0100817)1.97005320
42Trigonocephaly (HP:0000243)1.96924456
43Cutaneous finger syndactyly (HP:0010554)1.95698075
44Aortic dissection (HP:0002647)1.94847308
45Mitral stenosis (HP:0001718)1.94429396
46Absent speech (HP:0001344)1.92269211
47Increased number of teeth (HP:0011069)1.90796062
48Narrow palate (HP:0000189)1.89906993
49Volvulus (HP:0002580)1.88899125
50Chronic hepatic failure (HP:0100626)1.88873113
51Vascular tortuosity (HP:0004948)1.87827756
52Stomach cancer (HP:0012126)1.87647073
53Abnormality of the pubic bones (HP:0003172)1.87265026
54Sudden death (HP:0001699)1.86586039
55Blue irides (HP:0000635)1.86331544
56Abnormality of the parietal bone (HP:0002696)1.86309954
57Subacute progressive viral hepatitis (HP:0006572)1.85068906
58Urinary bladder sphincter dysfunction (HP:0002839)1.82299655
59Arterial tortuosity (HP:0005116)1.82009926
60Flat cornea (HP:0007720)1.81246694
61Dysmetric saccades (HP:0000641)1.79417639
62Premature rupture of membranes (HP:0001788)1.79004148
63Bladder diverticulum (HP:0000015)1.78911166
64Renal duplication (HP:0000075)1.77936213
65EEG with generalized epileptiform discharges (HP:0011198)1.77171249
66Epileptiform EEG discharges (HP:0011182)1.75982071
67Preaxial foot polydactyly (HP:0001841)1.75816922
68Hypoplastic labia majora (HP:0000059)1.75706514
69Asymmetry of the thorax (HP:0001555)1.74829482
70Lymphangioma (HP:0100764)1.72832944
71Dysdiadochokinesis (HP:0002075)1.72564673
72Abnormality of the metopic suture (HP:0005556)1.72151497
73Hypoplastic nipples (HP:0002557)1.72052453
74Aplasia involving bones of the extremities (HP:0009825)1.71784942
75Aplasia involving bones of the upper limbs (HP:0009823)1.71784942
76Aplasia of the phalanges of the hand (HP:0009802)1.71784942
77Hypsarrhythmia (HP:0002521)1.71295987
78Atrial fibrillation (HP:0005110)1.70525866
79Aplasia/Hypoplasia of the tibia (HP:0005772)1.69771581
80Poor eye contact (HP:0000817)1.69649684
81Astrocytoma (HP:0009592)1.69375482
82Abnormality of the astrocytes (HP:0100707)1.69375482
83Neonatal short-limb short stature (HP:0008921)1.68537754
84Omphalocele (HP:0001539)1.68368923
85Primary atrial arrhythmia (HP:0001692)1.68327048
86Pulmonic stenosis (HP:0001642)1.68254258
87Absent frontal sinuses (HP:0002688)1.67875146
88Limited hip movement (HP:0008800)1.67256983
89Abnormality of the corticospinal tract (HP:0002492)1.66686987
90Gaze-evoked nystagmus (HP:0000640)1.66585925
91Cubitus valgus (HP:0002967)1.66320701
92Wrist flexion contracture (HP:0001239)1.65656407
93Insidious onset (HP:0003587)1.65235972
94Termporal pattern (HP:0011008)1.65235972
95Abnormal pancreas size (HP:0012094)1.65214873
96Vitreoretinal degeneration (HP:0000655)1.64771087
97Generalized hypopigmentation of hair (HP:0011358)1.64499548
98Macroorchidism (HP:0000053)1.64098977
99Impaired social interactions (HP:0000735)1.63590701
100Abnormal social behavior (HP:0012433)1.63590701
101Fetal akinesia sequence (HP:0001989)1.62874596
102Advanced eruption of teeth (HP:0006288)1.62597863
103Cutaneous syndactyly (HP:0012725)1.62562282
104Widely spaced teeth (HP:0000687)1.62484603
105Abnormality of the labia majora (HP:0012881)1.62431296
106Alacrima (HP:0000522)1.61725460
107Wide anterior fontanel (HP:0000260)1.61211669
108Hemiparesis (HP:0001269)1.60943541
109Hyperacusis (HP:0010780)1.60628848
110Absent eyebrow (HP:0002223)1.60400870
111Abnormality of the labia minora (HP:0012880)1.60211940
112Sacral dimple (HP:0000960)1.59983212
113Abnormality of dentin (HP:0010299)1.59513215
114Optic nerve hypoplasia (HP:0000609)1.59227152
115Cerebellar dysplasia (HP:0007033)1.59127912
116Vertebral arch anomaly (HP:0008438)1.58319504
117Glioma (HP:0009733)1.58046806
118Broad metatarsal (HP:0001783)1.57969456
119Prolonged QT interval (HP:0001657)1.57901155
120Coronal craniosynostosis (HP:0004440)1.57280835
121Aortic aneurysm (HP:0004942)1.56942557
122Hypophosphatemic rickets (HP:0004912)1.56647955
123Spinal cord compression (HP:0002176)1.55740570
124Uterine leiomyosarcoma (HP:0002891)1.55582667
125Leiomyosarcoma (HP:0100243)1.55582667
126Round face (HP:0000311)1.55555815
127Obsessive-compulsive behavior (HP:0000722)1.55174203
128Partial agenesis of the corpus callosum (HP:0001338)1.55162026
129Hip contracture (HP:0003273)1.54791359
130Tibial bowing (HP:0002982)1.53973159
131Protruding tongue (HP:0010808)1.53952859
132Fibular hypoplasia (HP:0003038)1.53898488
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53897614
134Exotropia (HP:0000577)1.53652573
135Short chin (HP:0000331)1.52999370
136Natal tooth (HP:0000695)1.52389583
137Bell-shaped thorax (HP:0001591)1.52343405
138Wormian bones (HP:0002645)1.52318738
139Bronchomalacia (HP:0002780)1.52183910
140Genu recurvatum (HP:0002816)1.52043997
141Abnormality of salivation (HP:0100755)1.51827084
142Type II lissencephaly (HP:0007260)1.51393417
143Abnormality of the epiphyses of the hand (HP:0005924)1.50868171
144Bradycardia (HP:0001662)1.50742091
145Bulbous nose (HP:0000414)1.50265478
146Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.49467981
147Overriding aorta (HP:0002623)1.49460727
148Smooth philtrum (HP:0000319)1.48591274
149Mitral valve prolapse (HP:0001634)1.48333297
150Morphological abnormality of the middle ear (HP:0008609)1.48017206
151Decreased lacrimation (HP:0000633)1.46973875
152Oligodontia (HP:0000677)1.46912109
153Nephronophthisis (HP:0000090)1.46743574
154Megalencephaly (HP:0001355)1.46591346
155Agitation (HP:0000713)1.46490493
156Transitional cell carcinoma of the bladder (HP:0006740)1.46366899
157Intestinal atresia (HP:0011100)1.46221684
158Abnormality of the renal medulla (HP:0100957)1.45982109
159Hypoplasia of the iris (HP:0007676)1.45971070
160Bowel diverticulosis (HP:0005222)1.43439164
161Highly arched eyebrow (HP:0002553)1.40752481
162Knee flexion contracture (HP:0006380)1.38712073
163Septo-optic dysplasia (HP:0100842)1.38016498
164Hypoplasia of the maxilla (HP:0000327)1.37306544

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.12204562
2CASK2.96646960
3NTRK32.93498531
4LATS12.33426973
5MAP3K42.23202809
6PHKG12.11520183
7PHKG22.11520183
8LATS22.09687635
9INSRR1.96895844
10BMPR1B1.86002714
11CAMK1G1.75181424
12MAP2K71.73760826
13TAOK11.71657764
14SIK21.71620351
15EPHA41.68723322
16DMPK1.68649919
17NTRK21.67759973
18MAPK131.64409997
19TNIK1.53442021
20MINK11.51415906
21EPHB21.50062019
22ERBB31.43046204
23WNK41.35336213
24EPHA31.35086489
25MET1.33129976
26PAK61.31646042
27DYRK21.31411575
28SIK11.30852231
29DDR21.28539330
30MAP3K91.27292207
31CAMK1D1.24013740
32TAOK21.23752310
33DAPK21.19108707
34SGK21.18341246
35RIPK11.18293649
36CDC42BPA1.16672032
37KSR11.13329268
38STK391.12380204
39FGFR21.12370140
40PAK31.10619941
41FER1.09209273
42CDK121.07392943
43BRD41.06522430
44TRPM71.06208374
45PNCK1.06057653
46MARK21.03749622
47PLK21.02695213
48PRPF4B1.02384557
49PIK3CA1.01982684
50SGK30.95309112
51MAP2K40.91699291
52STK380.90432253
53ERBB20.90116521
54PKN10.89297825
55MYLK0.88467620
56AKT30.86816021
57CSNK1G20.86227426
58NUAK10.85503798
59SIK30.85417665
60FLT30.82961180
61SGK10.82019865
62PDGFRA0.81182882
63CDK30.80681757
64CDK50.80092868
65PRKD30.79584641
66SGK2230.79254498
67SGK4940.79254498
68ACVR1B0.78608882
69STK30.78465368
70MAP4K20.77850133
71CSNK1A1L0.77785024
72ADRBK10.76987947
73ADRBK20.76464775
74BCR0.75974003
75TTN0.75219834
76PRKCE0.74007651
77MAP3K70.73028925
78LMTK20.72969081
79ALK0.72965781
80ZAK0.70424702
81PRKCG0.70234851
82FGFR10.68840265
83PTK20.68528559
84ROCK10.67500715
85NTRK10.67199882
86EIF2AK20.66895955
87STK38L0.65744347
88PINK10.65191850
89PAK20.64303278
90CAMK40.64085923
91MTOR0.63894058
92ICK0.62751410
93TGFBR10.61867837
94CAMK2A0.61313213
95PRKG10.60181362
96PRKAA10.58504259
97RET0.58316827
98IRAK20.58007871
99WNK10.57310090
100CAMK10.56967669
101NLK0.55813215
102FRK0.55654303
103MELK0.55221481
104CAMKK10.54646920
105MAP2K10.54405423
106DYRK1A0.53769092
107PDGFRB0.53541470
108MAPK100.53075526
109ROCK20.52953841
110NEK60.52022698
111RPS6KA20.51835762
112PTK2B0.51171073
113STK110.50743200
114MKNK20.49592220
115STK160.49582155
116PRKCH0.49247920
117CSNK1D0.47705095
118GRK10.47257858
119PRKCZ0.46761104
120MAPK80.45701262
121PRKAA20.44508130
122WNK30.44183789
123RPS6KA30.44058371
124ERBB40.43677287
125GSK3B0.43122156
126CSNK1E0.42906284
127CAMK2D0.41247852
128ATM0.40342076
129MAP3K60.39812543
130CSNK1G10.39749202
131PKN20.39618219

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.72828204
2Axon guidance_Homo sapiens_hsa043602.16539057
3Circadian entrainment_Homo sapiens_hsa047131.95662957
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86078591
5Glutamatergic synapse_Homo sapiens_hsa047241.84979758
6Type II diabetes mellitus_Homo sapiens_hsa049301.77368155
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72628612
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.71024033
9Dilated cardiomyopathy_Homo sapiens_hsa054141.67811547
10GABAergic synapse_Homo sapiens_hsa047271.66747670
11Morphine addiction_Homo sapiens_hsa050321.65323557
12Long-term potentiation_Homo sapiens_hsa047201.63526928
13Basal cell carcinoma_Homo sapiens_hsa052171.62084319
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60053171
15Insulin secretion_Homo sapiens_hsa049111.56328054
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50184904
17Dopaminergic synapse_Homo sapiens_hsa047281.48612110
18Cholinergic synapse_Homo sapiens_hsa047251.47654563
19Taste transduction_Homo sapiens_hsa047421.46239005
20Synaptic vesicle cycle_Homo sapiens_hsa047211.42200277
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41164222
22Amphetamine addiction_Homo sapiens_hsa050311.40655280
23Salivary secretion_Homo sapiens_hsa049701.37280331
24Melanogenesis_Homo sapiens_hsa049161.35144296
25Oxytocin signaling pathway_Homo sapiens_hsa049211.32901925
26Endometrial cancer_Homo sapiens_hsa052131.32476294
27Long-term depression_Homo sapiens_hsa047301.31772797
28Hedgehog signaling pathway_Homo sapiens_hsa043401.30246020
29ErbB signaling pathway_Homo sapiens_hsa040121.29789018
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29594691
31Olfactory transduction_Homo sapiens_hsa047401.29586261
32Glioma_Homo sapiens_hsa052141.28218734
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27951216
34cAMP signaling pathway_Homo sapiens_hsa040241.27294339
35Lysine degradation_Homo sapiens_hsa003101.26614045
36Wnt signaling pathway_Homo sapiens_hsa043101.25963048
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24335154
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21998942
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.21663292
40Renin secretion_Homo sapiens_hsa049241.21395482
41Butanoate metabolism_Homo sapiens_hsa006501.20726002
42Hippo signaling pathway_Homo sapiens_hsa043901.19974834
43Gap junction_Homo sapiens_hsa045401.19757175
44Estrogen signaling pathway_Homo sapiens_hsa049151.17032955
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16846237
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16807481
47Serotonergic synapse_Homo sapiens_hsa047261.14274521
48Adherens junction_Homo sapiens_hsa045201.13385616
49Melanoma_Homo sapiens_hsa052181.11393449
50Gastric acid secretion_Homo sapiens_hsa049711.09561732
51Cocaine addiction_Homo sapiens_hsa050301.08048662
52Calcium signaling pathway_Homo sapiens_hsa040201.07992601
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07926084
54GnRH signaling pathway_Homo sapiens_hsa049121.07147650
55Dorso-ventral axis formation_Homo sapiens_hsa043201.03668336
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02678814
57Phototransduction_Homo sapiens_hsa047441.02350672
58Focal adhesion_Homo sapiens_hsa045100.98190634
59ECM-receptor interaction_Homo sapiens_hsa045120.98053999
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95679925
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93216701
62Renal cell carcinoma_Homo sapiens_hsa052110.93177671
63Protein digestion and absorption_Homo sapiens_hsa049740.92692982
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92460758
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89050367
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87509022
67MicroRNAs in cancer_Homo sapiens_hsa052060.87191337
68Colorectal cancer_Homo sapiens_hsa052100.85919110
69Rap1 signaling pathway_Homo sapiens_hsa040150.85599835
70Choline metabolism in cancer_Homo sapiens_hsa052310.85560438
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84271450
72Proteoglycans in cancer_Homo sapiens_hsa052050.82485240
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.82054167
74mTOR signaling pathway_Homo sapiens_hsa041500.80909432
75Ovarian steroidogenesis_Homo sapiens_hsa049130.80412452
76Insulin signaling pathway_Homo sapiens_hsa049100.79430845
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78322570
78Sphingolipid metabolism_Homo sapiens_hsa006000.77606187
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.77386215
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77303009
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76770623
82Ras signaling pathway_Homo sapiens_hsa040140.76629662
83Viral myocarditis_Homo sapiens_hsa054160.75856336
84Glucagon signaling pathway_Homo sapiens_hsa049220.75196543
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74300334
86AMPK signaling pathway_Homo sapiens_hsa041520.73231364
87Tight junction_Homo sapiens_hsa045300.72962122
88MAPK signaling pathway_Homo sapiens_hsa040100.72671709
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71788663
90ABC transporters_Homo sapiens_hsa020100.71592510
91Prostate cancer_Homo sapiens_hsa052150.71291874
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71138263
93Selenocompound metabolism_Homo sapiens_hsa004500.69322858
94Small cell lung cancer_Homo sapiens_hsa052220.66602517
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65390863
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.64806551
97TGF-beta signaling pathway_Homo sapiens_hsa043500.64675201
98Insulin resistance_Homo sapiens_hsa049310.63523286
99Bile secretion_Homo sapiens_hsa049760.62465623
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61718237
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61522296
102Tryptophan metabolism_Homo sapiens_hsa003800.61479712
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.60569156
104Pancreatic secretion_Homo sapiens_hsa049720.59995021
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57627689
106Circadian rhythm_Homo sapiens_hsa047100.57083969
107Chronic myeloid leukemia_Homo sapiens_hsa052200.56311487
108Pathways in cancer_Homo sapiens_hsa052000.55282936
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54982576
110Amoebiasis_Homo sapiens_hsa051460.54315753
111Non-small cell lung cancer_Homo sapiens_hsa052230.53680479
112Thyroid hormone synthesis_Homo sapiens_hsa049180.52653271
113Inositol phosphate metabolism_Homo sapiens_hsa005620.51424653
114Fatty acid biosynthesis_Homo sapiens_hsa000610.50743410
115FoxO signaling pathway_Homo sapiens_hsa040680.50192451
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.47463482

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