ERCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1artery development (GO:0060840)8.97298918
2positive regulation of interleukin-8 secretion (GO:2000484)8.74684852
3lymphangiogenesis (GO:0001946)8.67933555
4embryonic foregut morphogenesis (GO:0048617)6.92632458
5renal absorption (GO:0070293)6.31976492
6epithelial cell fate commitment (GO:0072148)6.20584374
7negative regulation of multicellular organism growth (GO:0040015)5.67720329
8response to UV-B (GO:0010224)5.60186302
9regulation of interleukin-8 secretion (GO:2000482)5.54544185
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.41869836
11lens morphogenesis in camera-type eye (GO:0002089)5.41609837
12positive regulation of urine volume (GO:0035810)5.20885644
13cell proliferation in forebrain (GO:0021846)5.07847536
14peripheral nervous system neuron development (GO:0048935)5.07440729
15viral transcription (GO:0019083)4.81505760
16organ growth (GO:0035265)4.80494679
17establishment of integrated proviral latency (GO:0075713)4.65152674
18hyaluronan catabolic process (GO:0030214)4.62472734
19regulation of mitotic spindle organization (GO:0060236)4.55931978
20glycine transport (GO:0015816)4.55626060
21purine deoxyribonucleotide catabolic process (GO:0009155)4.53757220
22negative regulation of protein tyrosine kinase activity (GO:0061099)4.49426392
23translational termination (GO:0006415)4.47150740
24DNA deamination (GO:0045006)4.40860735
25neuron fate specification (GO:0048665)4.38798227
26protein complex biogenesis (GO:0070271)4.37018537
27regulation of mitochondrial translation (GO:0070129)4.34792199
28base-excision repair, AP site formation (GO:0006285)4.27165027
29regulation of activin receptor signaling pathway (GO:0032925)4.24081485
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.23842986
31lipopolysaccharide biosynthetic process (GO:0009103)4.17921086
32spliceosomal complex assembly (GO:0000245)4.17695736
33negative regulation of B cell apoptotic process (GO:0002903)4.16719400
34translational elongation (GO:0006414)4.06422777
35* multicellular organismal aging (GO:0010259)4.00897664
36gastrulation with mouth forming second (GO:0001702)4.00453185
37cellular response to zinc ion (GO:0071294)4.00441746
38activin receptor signaling pathway (GO:0032924)3.99261717
39negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.96550803
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.89428719
41deoxyribonucleotide catabolic process (GO:0009264)3.88350243
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85495197
43iron-sulfur cluster assembly (GO:0016226)3.84803218
44metallo-sulfur cluster assembly (GO:0031163)3.84803218
45energy coupled proton transport, down electrochemical gradient (GO:0015985)3.84749673
46ATP synthesis coupled proton transport (GO:0015986)3.84749673
47mitochondrial respiratory chain complex assembly (GO:0033108)3.82826572
48cotranslational protein targeting to membrane (GO:0006613)3.79957484
49protein targeting to ER (GO:0045047)3.78672097
50endothelial cell differentiation (GO:0045446)3.77642780
51gamma-aminobutyric acid transport (GO:0015812)3.76905291
52mannosylation (GO:0097502)3.75167569
53protein maturation by protein folding (GO:0022417)3.73916424
54establishment of viral latency (GO:0019043)3.72649971
55forebrain neuron development (GO:0021884)3.70469969
56DNA integration (GO:0015074)3.68240786
57gastrulation (GO:0007369)3.67727581
58ribosomal small subunit assembly (GO:0000028)3.67328781
59GTP biosynthetic process (GO:0006183)3.67061181
60respiratory chain complex IV assembly (GO:0008535)3.67006537
61protein deneddylation (GO:0000338)3.66676010
62deoxyribose phosphate catabolic process (GO:0046386)3.64798685
63cellular protein complex disassembly (GO:0043624)3.63491786
64viral life cycle (GO:0019058)3.62939782
65translational initiation (GO:0006413)3.62628910
66purine deoxyribonucleotide metabolic process (GO:0009151)3.58053234
67blastocyst development (GO:0001824)3.57381130
68mitotic nuclear envelope reassembly (GO:0007084)3.56936456
69nuclear envelope reassembly (GO:0031468)3.56936456
70regulation of urine volume (GO:0035809)3.53898282
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.53202174
72protein targeting to mitochondrion (GO:0006626)3.53001692
73protein localization to endoplasmic reticulum (GO:0070972)3.50620718
74peptidyl-histidine modification (GO:0018202)3.48296282
75* UV protection (GO:0009650)3.46335752
76autophagic vacuole fusion (GO:0000046)3.45849532
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.45255194
78lipopolysaccharide metabolic process (GO:0008653)3.43277678
79pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42697350
80retinal ganglion cell axon guidance (GO:0031290)3.42570430
81UTP biosynthetic process (GO:0006228)3.41629411
82establishment of protein localization to mitochondrion (GO:0072655)3.39396169
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38639115
84heme biosynthetic process (GO:0006783)3.38529923
85mitotic metaphase plate congression (GO:0007080)3.37565956
86protein complex disassembly (GO:0043241)3.31948062
87viral entry into host cell (GO:0046718)3.31918200
88respiratory electron transport chain (GO:0022904)3.31213205
89electron transport chain (GO:0022900)3.30893480
90cullin deneddylation (GO:0010388)3.27053400
91termination of RNA polymerase III transcription (GO:0006386)3.26338181
92transcription elongation from RNA polymerase III promoter (GO:0006385)3.26338181
93GDP-mannose metabolic process (GO:0019673)3.26168498
94limb bud formation (GO:0060174)3.25863563
95guanosine-containing compound biosynthetic process (GO:1901070)3.25206086
96rRNA modification (GO:0000154)3.21504873
97macromolecular complex disassembly (GO:0032984)3.20689683
982-deoxyribonucleotide metabolic process (GO:0009394)3.20488027
99response to gravity (GO:0009629)3.19425814
100protoporphyrinogen IX biosynthetic process (GO:0006782)3.19238634
101deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.17523398
102regulation of spindle organization (GO:0090224)3.17263702
103nucleotide salvage (GO:0043173)3.16837992
104maturation of SSU-rRNA (GO:0030490)3.13659992
105negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.10221967
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09799678
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09799678
108sexual reproduction (GO:0019953)3.08937481
109activation of MAPKKK activity (GO:0000185)3.08449242
110protein localization to mitochondrion (GO:0070585)3.07064098
111sequestering of actin monomers (GO:0042989)3.05639351
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04330400
113regulation of fibroblast migration (GO:0010762)3.03391361
114deoxyribose phosphate metabolic process (GO:0019692)3.03223678
115oxidative phosphorylation (GO:0006119)3.02957395
116spliceosomal snRNP assembly (GO:0000387)3.02941936
117translation (GO:0006412)3.01460306
118UTP metabolic process (GO:0046051)2.99287441
119de novo posttranslational protein folding (GO:0051084)2.98596320
120mesoderm development (GO:0007498)2.98576108
121formation of translation preinitiation complex (GO:0001731)2.98208857
122pseudouridine synthesis (GO:0001522)2.97009877
123pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.96997116
124regulation of cellular amino acid metabolic process (GO:0006521)2.96546935
125CTP biosynthetic process (GO:0006241)2.96267673
126CTP metabolic process (GO:0046036)2.96267673
127positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.96038995
128negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95519316
129purine nucleotide salvage (GO:0032261)2.93116976
130proteasome assembly (GO:0043248)2.91903716
131regulation of B cell apoptotic process (GO:0002902)2.91555846
132rRNA methylation (GO:0031167)2.90724483
133pancreas development (GO:0031016)2.90139376
134modulation by virus of host morphology or physiology (GO:0019048)2.90098102
135inner mitochondrial membrane organization (GO:0007007)2.89564121
136cellular response to interferon-beta (GO:0035458)2.88994946
137C-terminal protein lipidation (GO:0006501)2.87724607
138ribosomal large subunit biogenesis (GO:0042273)2.87453021
139entry into host (GO:0044409)2.87451000
140entry into other organism involved in symbiotic interaction (GO:0051828)2.87451000
141movement in host environment (GO:0052126)2.87451000
142entry into host cell (GO:0030260)2.87451000
143movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.87451000
144entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.87451000
145negative regulation of ligase activity (GO:0051352)2.87264315
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87264315
147cytochrome complex assembly (GO:0017004)2.86247575
148negative regulation of androgen receptor signaling pathway (GO:0060766)2.85678300
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84248858
150signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84248858
151GPI anchor biosynthetic process (GO:0006506)2.84224248
152metaphase plate congression (GO:0051310)2.83824025
153preassembly of GPI anchor in ER membrane (GO:0016254)2.83607470
154pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83498998
155purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82570755
156pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81833256
157signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80804675
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80804675
159signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80804675
160dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.80691424
161type B pancreatic cell proliferation (GO:0044342)2.80561503
162de novo protein folding (GO:0006458)2.80361131
163purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.79575781
164ribosomal small subunit biogenesis (GO:0042274)2.79357584
165deoxyribonucleotide metabolic process (GO:0009262)2.77360501
166pyrimidine nucleotide catabolic process (GO:0006244)2.77175542
167purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77149516
168blood vessel remodeling (GO:0001974)2.77041346
169negative regulation of JAK-STAT cascade (GO:0046426)2.76177272
170nucleoside salvage (GO:0043174)2.75414614
171GMP metabolic process (GO:0046037)2.74337582
172DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73743280
173mitochondrial respiratory chain complex I assembly (GO:0032981)2.70483759
174NADH dehydrogenase complex assembly (GO:0010257)2.70483759
175mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70483759
176regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)2.69355536
177signal transduction involved in cell cycle checkpoint (GO:0072395)2.69024594
178positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68025170
179chaperone-mediated protein transport (GO:0072321)2.66059872
180anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65282965
181substrate-independent telencephalic tangential interneuron migration (GO:0021843)10.2634876
182substrate-independent telencephalic tangential migration (GO:0021826)10.2634876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.11095233
2E2F7_22180533_ChIP-Seq_HELA_Human5.49433146
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.26967248
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse4.09398791
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86131701
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.49777816
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26674944
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.22151853
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.99757853
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95708161
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.77241960
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73050562
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68570264
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59568660
15XRN2_22483619_ChIP-Seq_HELA_Human2.55195529
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47289397
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44888575
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.34023547
19ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.33431864
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25023485
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14339657
22KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.13772804
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09775938
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02824254
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.95413385
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.91845792
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91338773
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89304882
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87571964
30* ELF1_20517297_ChIP-Seq_JURKAT_Human1.86524297
31ELK1_22589737_ChIP-Seq_MCF10A_Human1.84708712
32DCP1A_22483619_ChIP-Seq_HELA_Human1.80235698
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.78574588
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77708325
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76799254
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.74665548
37* NANOG_16153702_ChIP-ChIP_HESCs_Human1.73425858
38BCL6_27268052_Chip-Seq_Bcells_Human1.69744131
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68761060
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66377958
41VDR_23849224_ChIP-Seq_CD4+_Human1.66133310
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.65528302
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.63882116
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62641136
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.61684062
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60760484
47* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59315610
48* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59285070
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.58990154
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.58293900
51P68_20966046_ChIP-Seq_HELA_Human1.57149878
52LXR_22292898_ChIP-Seq_THP-1_Human1.55962050
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54782646
54ELK1_19687146_ChIP-ChIP_HELA_Human1.53724947
55VDR_21846776_ChIP-Seq_THP-1_Human1.53600069
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49997084
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49963614
58FOXP3_21729870_ChIP-Seq_TREG_Human1.49206846
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46756173
60SOX2_18692474_ChIP-Seq_MEFs_Mouse1.46551937
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44441569
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43842941
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43054953
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42231379
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42138171
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42040122
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41266958
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40833566
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40438682
70* FOXP1_21924763_ChIP-Seq_HESCs_Human1.39719769
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37628654
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37597802
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.34664715
74BCOR_27268052_Chip-Seq_Bcells_Human1.33196582
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33142948
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32769611
77KDM5A_27292631_Chip-Seq_BREAST_Human1.30244024
78* TTF2_22483619_ChIP-Seq_HELA_Human1.29634333
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28178378
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27930285
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27284207
82CIITA_25753668_ChIP-Seq_RAJI_Human1.24138690
83E2F1_20622854_ChIP-Seq_HELA_Human1.22908005
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22864428
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.22391871
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21724610
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.21308353
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.20628309
89PHF8_20622854_ChIP-Seq_HELA_Human1.19734156
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18322137
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18153788
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15289923
93CTCF_20526341_ChIP-Seq_ESCs_Human1.14759491
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13924884
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.13847576
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13726169
97RARB_24833708_ChIP-Seq_LIVER_Mouse1.13297379
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11974181
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10889962
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10801343
101FOXM1_23109430_ChIP-Seq_U2OS_Human1.09414297
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09091470
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08517198
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08361581
105P300_27268052_Chip-Seq_Bcells_Human1.07912062
106* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07900204
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07702731
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07508980
109* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06771770
110* MYC_18940864_ChIP-ChIP_HL60_Human1.06422539
111SOX2_16153702_ChIP-ChIP_HESCs_Human1.06251488
112* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06071682
113ATF3_27146783_Chip-Seq_COLON_Human1.04892842
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02952850
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02675514
116ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02478425
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02298646
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02220911
119* E2F1_21310950_ChIP-Seq_MCF-7_Human1.02143973
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01459222
121* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00549779
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00217435
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98929489
124SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98856389
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.97612031
126* YY1_22570637_ChIP-Seq_MALME-3M_Human0.97393432
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96799745
128TP53_22127205_ChIP-Seq_IMR90_Human0.95809786
129* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95305920
130MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94749858
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91697685
132GABP_19822575_ChIP-Seq_HepG2_Human0.90888401
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.90588801
134* MYC_22102868_ChIP-Seq_BL_Human0.90423761
135* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89538742
136SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87097302
137* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86349212
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.86184693
139* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85946605
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84565176
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84338987
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83824571
143* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81800643
144NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81177403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology7.16159197
2MP0003279_aneurysm4.65207987
3MP0002249_abnormal_larynx_morphology4.52585805
4MP0000013_abnormal_adipose_tissue4.34639409
5MP0009384_cardiac_valve_regurgitation4.00445136
6MP0003950_abnormal_plasma_membrane3.75912237
7MP0003806_abnormal_nucleotide_metabolis3.73442429
8MP0004133_heterotaxia3.51764862
9MP0005257_abnormal_intraocular_pressure3.08316202
10MP0008438_abnormal_cutaneous_collagen2.65408345
11MP0000372_irregular_coat_pigmentation2.57482765
12MP0002653_abnormal_ependyma_morphology2.54345448
13MP0005083_abnormal_biliary_tract2.51813984
14MP0005670_abnormal_white_adipose2.42862589
15MP0003186_abnormal_redox_activity2.38373934
16MP0010094_abnormal_chromosome_stability2.27235548
17* MP0006036_abnormal_mitochondrial_physio2.12737425
18MP0002837_dystrophic_cardiac_calcinosis2.11183543
19MP0002102_abnormal_ear_morphology2.07925510
20* MP0003786_premature_aging2.01240240
21MP0005330_cardiomyopathy1.94892987
22MP0003890_abnormal_embryonic-extraembry1.91724628
23MP0000049_abnormal_middle_ear1.87374451
24MP0005165_increased_susceptibility_to1.79898983
25MP0005503_abnormal_tendon_morphology1.77967284
26MP0002932_abnormal_joint_morphology1.76455854
27MP0003385_abnormal_body_wall1.72113874
28MP0008932_abnormal_embryonic_tissue1.71135691
29MP0006292_abnormal_olfactory_placode1.71106645
30MP0005075_abnormal_melanosome_morpholog1.70689483
31MP0000537_abnormal_urethra_morphology1.69140515
32MP0002638_abnormal_pupillary_reflex1.62428638
33MP0001270_distended_abdomen1.62373736
34MP0001853_heart_inflammation1.59666025
35MP0001502_abnormal_circadian_rhythm1.57763318
36MP0000003_abnormal_adipose_tissue1.55491621
37MP0005058_abnormal_lysosome_morphology1.54648157
38* MP0004142_abnormal_muscle_tone1.53341951
39MP0008775_abnormal_heart_ventricle1.47572842
40MP0002282_abnormal_trachea_morphology1.47303067
41MP0001905_abnormal_dopamine_level1.45381114
42MP0000015_abnormal_ear_pigmentation1.43416367
43* MP0008007_abnormal_cellular_replicative1.42196032
44MP0003315_abnormal_perineum_morphology1.39363681
45MP0001545_abnormal_hematopoietic_system1.36464900
46MP0005397_hematopoietic_system_phenotyp1.36464900
47MP0002234_abnormal_pharynx_morphology1.35777439
48MP0004957_abnormal_blastocyst_morpholog1.33973234
49MP0000343_altered_response_to1.31058639
50MP0004858_abnormal_nervous_system1.30528640
51* MP0000759_abnormal_skeletal_muscle1.27021828
52* MP0000358_abnormal_cell_content/1.26271236
53MP0002277_abnormal_respiratory_mucosa1.25931448
54MP0002751_abnormal_autonomic_nervous1.25453045
55MP0005464_abnormal_platelet_physiology1.24206035
56MP0009278_abnormal_bone_marrow1.23198039
57MP0003011_delayed_dark_adaptation1.21268031
58MP0005275_abnormal_skin_tensile1.20607118
59MP0004233_abnormal_muscle_weight1.20371799
60MP0004084_abnormal_cardiac_muscle1.18994602
61MP0008789_abnormal_olfactory_epithelium1.18701276
62MP0003941_abnormal_skin_development1.18361722
63MP0005023_abnormal_wound_healing1.18351644
64MP0000432_abnormal_head_morphology1.16278823
65MP0003755_abnormal_palate_morphology1.12592438
66MP0000733_abnormal_muscle_development1.11170742
67* MP0002114_abnormal_axial_skeleton1.09292433
68MP0001919_abnormal_reproductive_system1.09223730
69MP0000163_abnormal_cartilage_morphology1.07449689
70MP0005171_absent_coat_pigmentation1.06406577
71MP0001661_extended_life_span1.05530948
72MP0002095_abnormal_skin_pigmentation1.05522806
73MP0003878_abnormal_ear_physiology1.05252546
74MP0005377_hearing/vestibular/ear_phenot1.05252546
75MP0003938_abnormal_ear_development1.04676620
76MP0003075_altered_response_to1.04189397
77MP0004147_increased_porphyrin_level1.03776990
78MP0002938_white_spotting1.03685056
79MP0008770_decreased_survivor_rate1.02978755
80MP0010368_abnormal_lymphatic_system1.01854920
81MP0005390_skeleton_phenotype1.00615692
82MP0001958_emphysema0.99883349
83MP0001485_abnormal_pinna_reflex0.99819680
84MP0002177_abnormal_outer_ear0.99059268
85MP0002972_abnormal_cardiac_muscle0.98225393
86MP0003077_abnormal_cell_cycle0.97682125
87MP0002116_abnormal_craniofacial_bone0.97437100
88MP0002160_abnormal_reproductive_system0.97168527
89MP0000762_abnormal_tongue_morphology0.94373980
90MP0001986_abnormal_taste_sensitivity0.93406997
91MP0008875_abnormal_xenobiotic_pharmacok0.93346025
92MP0004134_abnormal_chest_morphology0.92243509
93MP0009780_abnormal_chondrocyte_physiolo0.91326822
94MP0004808_abnormal_hematopoietic_stem0.91068374
95MP0002108_abnormal_muscle_morphology0.90548819
96MP0009379_abnormal_foot_pigmentation0.90262013
97MP0000750_abnormal_muscle_regeneration0.88392246
98MP0009840_abnormal_foam_cell0.85974004
99MP0002113_abnormal_skeleton_development0.85939999
100* MP0003111_abnormal_nucleus_morphology0.85035969
101MP0001243_abnormal_dermal_layer0.84836924
102MP0001542_abnormal_bone_strength0.83869194
103MP0004087_abnormal_muscle_fiber0.83430237
104MP0003693_abnormal_embryo_hatching0.83111303
105MP0005623_abnormal_meninges_morphology0.82704373
106MP0000858_altered_metastatic_potential0.82563388
107MP0000749_muscle_degeneration0.82264485
108MP0006072_abnormal_retinal_apoptosis0.81750875
109* MP0010771_integument_phenotype0.81519355
110MP0002269_muscular_atrophy0.81236282
111MP0004145_abnormal_muscle_electrophysio0.79600061
112MP0004272_abnormal_basement_membrane0.79498806
113MP0002697_abnormal_eye_size0.79225864
114MP0004742_abnormal_vestibular_system0.79168568
115MP0002295_abnormal_pulmonary_circulatio0.77371559
116MP0005164_abnormal_response_to0.77355922
117* MP0000350_abnormal_cell_proliferation0.77335802
118MP0005369_muscle_phenotype0.77147756
119* MP0002019_abnormal_tumor_incidence0.76274237
120MP0002111_abnormal_tail_morphology0.76170872
121MP0009250_abnormal_appendicular_skeleto0.75787137
122MP0005174_abnormal_tail_pigmentation0.75259375
123MP0000747_muscle_weakness0.75253440
124MP0005451_abnormal_body_composition0.74315631
125MP0005508_abnormal_skeleton_morphology0.73585313
126MP0005620_abnormal_muscle_contractility0.73411954
127MP0002933_joint_inflammation0.73070251
128MP0002396_abnormal_hematopoietic_system0.71897038
129MP0005595_abnormal_vascular_smooth0.71014246
130MP0001286_abnormal_eye_development0.70967532
131MP0002106_abnormal_muscle_physiology0.70709724
132MP0000613_abnormal_salivary_gland0.70559873
133MP0003718_maternal_effect0.70064091
134MP0008260_abnormal_autophagy0.69864509
135MP0002115_abnormal_skeleton_extremities0.69197149
136MP0003436_decreased_susceptibility_to0.68470846
137MP0002272_abnormal_nervous_system0.67726327
138* MP0004197_abnormal_fetal_growth/weight/0.67702310
139MP0005408_hypopigmentation0.66546682
140MP0008961_abnormal_basal_metabolism0.66320817
141MP0002132_abnormal_respiratory_system0.66143760
142MP0003191_abnormal_cellular_cholesterol0.65960759
143MP0009046_muscle_twitch0.65500976
144* MP0008058_abnormal_DNA_repair0.65440361
145MP0003935_abnormal_craniofacial_develop0.65123083
146MP0009053_abnormal_anal_canal0.64959332
147MP0002109_abnormal_limb_morphology0.63810910
148MP0006054_spinal_hemorrhage0.63304974
149MP0002332_abnormal_exercise_endurance0.62374257
150MP0000467_abnormal_esophagus_morphology0.62247398
151MP0003566_abnormal_cell_adhesion0.61748930
152MP0003937_abnormal_limbs/digits/tail_de0.61029080
153MP0005389_reproductive_system_phenotype0.60954990
154MP0001348_abnormal_lacrimal_gland0.60881004
155MP0005499_abnormal_olfactory_system0.60712966
156MP0005394_taste/olfaction_phenotype0.60712966
157MP0002060_abnormal_skin_morphology0.60275648
158MP0002084_abnormal_developmental_patter0.59688832
159MP0003828_pulmonary_edema0.59171218
160MP0000751_myopathy0.56967908
161MP0002210_abnormal_sex_determination0.56836401
162* MP0002970_abnormal_white_adipose0.56569080
163* MP0010770_preweaning_lethality0.56143644
164* MP0002082_postnatal_lethality0.56143644
165MP0005375_adipose_tissue_phenotype0.54752670

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)9.54501510
2Morphological abnormality of the middle ear (HP:0008609)8.39975338
3Abnormality of the aortic arch (HP:0012303)8.16528817
4Large eyes (HP:0001090)6.31851351
5Hyperacusis (HP:0010780)6.15066760
6Abnormal number of erythroid precursors (HP:0012131)5.73731586
7Limb dystonia (HP:0002451)5.42301184
8Abnormality of cells of the erythroid lineage (HP:0012130)5.27725302
9Overlapping toe (HP:0001845)5.16270964
10Broad alveolar ridges (HP:0000187)4.99275494
11Tented upper lip vermilion (HP:0010804)4.82284755
12Self-mutilation (HP:0000742)4.74651433
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.55264302
14Abnormality of chromosome segregation (HP:0002916)4.24890752
15Muscle fiber inclusion bodies (HP:0100299)4.09925558
16Broad palm (HP:0001169)4.07466094
17Hepatocellular necrosis (HP:0001404)3.93704349
18Abnormal mitochondria in muscle tissue (HP:0008316)3.89175777
19Abnormality of molar (HP:0011077)3.69850523
20Abnormality of molar morphology (HP:0011070)3.69850523
21Abnormality of the dental root (HP:0006486)3.69485248
22Taurodontia (HP:0000679)3.69485248
23Abnormality of permanent molar morphology (HP:0011071)3.69485248
24Tetraplegia (HP:0002445)3.54946887
25Macrocytic anemia (HP:0001972)3.42389268
26Progressive macrocephaly (HP:0004481)3.21494619
27Impaired pain sensation (HP:0007328)3.16661040
28Abnormality of pain sensation (HP:0010832)3.16661040
29Abnormality of the dental pulp (HP:0006479)3.16108356
30Mesangial abnormality (HP:0001966)3.08727028
31Upper limb amyotrophy (HP:0009129)3.07914708
32Distal upper limb amyotrophy (HP:0007149)3.07914708
33Muscle fiber atrophy (HP:0100295)3.07449712
34Abnormality of the alveolar ridges (HP:0006477)3.03705102
35Type I transferrin isoform profile (HP:0003642)3.03486831
36Generalized hypotonia (HP:0001290)3.02973948
37Hepatic necrosis (HP:0002605)3.01256441
38Nemaline bodies (HP:0003798)3.00908016
39Type 2 muscle fiber atrophy (HP:0003554)3.00058014
40Premature rupture of membranes (HP:0001788)2.97868359
41Prominent supraorbital ridges (HP:0000336)2.97481709
42Type 1 muscle fiber predominance (HP:0003803)2.94190685
43Mitochondrial inheritance (HP:0001427)2.79094669
44Abnormal protein glycosylation (HP:0012346)2.74700838
45Abnormal glycosylation (HP:0012345)2.74700838
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.74700838
47Abnormal protein N-linked glycosylation (HP:0012347)2.74700838
48Exercise intolerance (HP:0003546)2.73954413
49Distal lower limb muscle weakness (HP:0009053)2.72676393
50Muscle fiber splitting (HP:0003555)2.72139491
51Hoarse voice (HP:0001609)2.70996397
52Increased intramyocellular lipid droplets (HP:0012240)2.70520618
53Hypercholesterolemia (HP:0003124)2.68313210
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66615726
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66615726
56Wide anterior fontanel (HP:0000260)2.63276446
57Mildly elevated creatine phosphokinase (HP:0008180)2.62568916
58Abnormality of the anterior horn cell (HP:0006802)2.61500265
59Degeneration of anterior horn cells (HP:0002398)2.61500265
60Renal dysplasia (HP:0000110)2.60186663
61Difficulty climbing stairs (HP:0003551)2.60166169
62Lactic acidosis (HP:0003128)2.56749178
63Protrusio acetabuli (HP:0003179)2.55879071
64Atrioventricular canal defect (HP:0006695)2.53667737
65Exocrine pancreatic insufficiency (HP:0001738)2.52931712
66Increased muscle lipid content (HP:0009058)2.47528911
67Hypertensive crisis (HP:0100735)2.45286924
68Limb-girdle muscle atrophy (HP:0003797)2.41494790
69Abnormality of the calf musculature (HP:0001430)2.36460663
70Distal lower limb amyotrophy (HP:0008944)2.34933337
71Abnormal pupillary function (HP:0007686)2.34881811
72Synophrys (HP:0000664)2.34829927
73Lissencephaly (HP:0001339)2.33079066
74Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26442993
75Molar tooth sign on MRI (HP:0002419)2.25845322
76Abnormality of midbrain morphology (HP:0002418)2.25845322
77Testicular atrophy (HP:0000029)2.25379252
78Progressive microcephaly (HP:0000253)2.23758445
79Generalized amyotrophy (HP:0003700)2.21735821
80Irregular epiphyses (HP:0010582)2.20067408
81Opisthotonus (HP:0002179)2.19655216
82Cerebral edema (HP:0002181)2.16545368
83Aplastic anemia (HP:0001915)2.15309735
84Follicular hyperkeratosis (HP:0007502)2.15030494
85Pallor (HP:0000980)2.15017981
86Ragged-red muscle fibers (HP:0003200)2.13980398
87Lipid accumulation in hepatocytes (HP:0006561)2.13307898
88Prolonged neonatal jaundice (HP:0006579)2.13094595
89Increased CSF lactate (HP:0002490)2.13092032
90Progressive muscle weakness (HP:0003323)2.12440903
91Delayed gross motor development (HP:0002194)2.08693885
92Microvesicular hepatic steatosis (HP:0001414)2.08579613
93Abnormal respiratory motile cilium morphology (HP:0005938)2.07715375
94Abnormal respiratory epithelium morphology (HP:0012253)2.07715375
95Elevated erythrocyte sedimentation rate (HP:0003565)2.06858427
96Patellar aplasia (HP:0006443)2.06038583
97Rib fusion (HP:0000902)2.05404159
98Joint stiffness (HP:0001387)2.04600837
99Triangular face (HP:0000325)2.02318759
100Weak cry (HP:0001612)2.01748999
101Hypertriglyceridemia (HP:0002155)2.01454162
102Onycholysis (HP:0001806)2.01171101
103Round ear (HP:0100830)1.98749017
104Emotional lability (HP:0000712)1.98567206
105Optic disc pallor (HP:0000543)1.96815729
106Redundant skin (HP:0001582)1.96429129
107Abnormal number of incisors (HP:0011064)1.96387359
108Fatigable weakness (HP:0003473)1.95891143
109Abnormality of the neuromuscular junction (HP:0003398)1.95891143
1103-Methylglutaconic aciduria (HP:0003535)1.95401616
111Fragile nails (HP:0001808)1.93886064
112Rough bone trabeculation (HP:0100670)1.93095795
113Nonimmune hydrops fetalis (HP:0001790)1.91100953
114Hyperthyroidism (HP:0000836)1.90575454
115True hermaphroditism (HP:0010459)1.90450635
116Aplasia/Hypoplasia of the patella (HP:0006498)1.89790738
117Poikiloderma (HP:0001029)1.89387361
118Supernumerary ribs (HP:0005815)1.88407067
119Fused cervical vertebrae (HP:0002949)1.87493892
120Aplasia/Hypoplasia involving the musculature (HP:0001460)1.87471219
121Amniotic constriction ring (HP:0009775)1.85735191
122Abnormality of placental membranes (HP:0011409)1.85735191
123Dicarboxylic aciduria (HP:0003215)1.85586583
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85586583
125Gliosis (HP:0002171)1.84433140
126Supernumerary bones of the axial skeleton (HP:0009144)1.83578457
127Spinal rigidity (HP:0003306)1.83224466
128Elbow flexion contracture (HP:0002987)1.82857227
129Split foot (HP:0001839)1.81140898
130Abnormal respiratory motile cilium physiology (HP:0012261)1.80785311
131Pancreatic fibrosis (HP:0100732)1.80294194
132Petechiae (HP:0000967)1.79842742
133Microretrognathia (HP:0000308)1.78572828
134Squamous cell carcinoma (HP:0002860)1.78519991
135Respiratory insufficiency due to muscle weakness (HP:0002747)1.76644934
136Rhinitis (HP:0012384)1.75577655
137Intellectual disability, progressive (HP:0006887)1.75075064
138Midface retrusion (HP:0011800)1.75066514
139Decreased testicular size (HP:0008734)1.74983649
140Abnormality of the tricuspid valve (HP:0001702)1.74404340
141Seborrheic dermatitis (HP:0001051)1.74153585
142Entropion (HP:0000621)1.74093411
143Myopathic facies (HP:0002058)1.73973798
144Slender build (HP:0001533)1.73767216
145Selective tooth agenesis (HP:0001592)1.73451396
146Nephronophthisis (HP:0000090)1.72989027
147Focal dystonia (HP:0004373)1.72298959
148CNS demyelination (HP:0007305)1.71783619
149Short nail (HP:0001799)1.71150111
150Sclerocornea (HP:0000647)1.70875864
151Acute encephalopathy (HP:0006846)1.70457598
152Increased hepatocellular lipid droplets (HP:0006565)1.70185152
153Vertebral compression fractures (HP:0002953)1.70163129
154Atelectasis (HP:0100750)1.69595990
155Neonatal short-limb short stature (HP:0008921)1.68538240
156Tapered finger (HP:0001182)1.66592917
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.66043181
158Absent epiphyses (HP:0010577)1.66043181
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65945576
160Protruding ear (HP:0000411)1.65886961
161Respiratory failure (HP:0002878)1.62589488
162Spinal muscular atrophy (HP:0007269)1.60342984
163Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.53920745
164Lower limb amyotrophy (HP:0007210)1.53865777
165Short palm (HP:0004279)1.53227530
166Renal Fanconi syndrome (HP:0001994)1.52536544
167Reticulocytopenia (HP:0001896)1.49902151
168Increased serum lactate (HP:0002151)1.49810062
169Acute necrotizing encephalopathy (HP:0006965)1.49329116
170Generalized myoclonic seizures (HP:0002123)1.45599911
171Biconcave vertebral bodies (HP:0004586)1.43731325
172Delayed CNS myelination (HP:0002188)1.43704406
173Exertional dyspnea (HP:0002875)1.41363966
174Hypohidrosis (HP:0000966)1.39050436
175Vertebral clefting (HP:0008428)1.38995887
176Increased connective tissue (HP:0009025)1.38045920
177Delayed cranial suture closure (HP:0000270)1.37701162
178Thrombocytosis (HP:0001894)1.35816897
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.34422719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.15886787
2PRPF4B4.99832020
3MKNK23.64709104
4TRIB33.52076626
5BCKDK3.43218829
6TAOK23.20047326
7EPHB23.00600675
8PIM22.99261726
9FLT32.94352874
10MKNK12.91529912
11VRK12.86514169
12NME22.50304791
13ICK2.49102813
14LIMK12.45054114
15TESK12.34149839
16ABL22.33239215
17TESK22.30694643
18BUB12.29640700
19IRAK32.11121662
20PAK42.09516474
21MAPKAPK31.98009774
22CCNB11.96756561
23ERN11.95971158
24LATS21.91816622
25MUSK1.81470342
26TLK11.79823207
27EPHB11.75453503
28MAPK151.70636996
29MAP3K111.62628476
30KDR1.60700347
31TTN1.60197024
32SRPK11.60153042
33EIF2AK11.56258496
34LMTK21.52654826
35RPS6KA41.51122121
36ARAF1.48654705
37NME11.47189261
38PHKG21.35943690
39PHKG11.35943690
40DAPK31.34408283
41CDK81.33760675
42EIF2AK31.31389404
43AURKA1.24572631
44BRAF1.22810890
45ILK1.18924372
46MAP4K21.16878319
47MOS1.15994522
48PRKD21.12990742
49DAPK11.11160401
50PTK2B1.08341325
51MYLK1.08065040
52PRKCI1.06560736
53ERBB31.04454835
54BCR1.02884460
55STK40.99647082
56STK160.99150772
57PAK10.99121499
58MST40.97681948
59CSNK1G30.97505371
60TSSK60.96420544
61TGFBR10.92948318
62TBK10.92734796
63MAP3K30.90899778
64IKBKB0.90264281
65CHUK0.89016553
66WEE10.88845136
67PAK60.85437725
68DYRK20.82818980
69RPS6KA50.82227529
70AKT20.81452717
71PTK60.80102737
72CASK0.79052957
73ERBB40.77483185
74CSNK1A1L0.72966720
75EPHA20.72181909
76CDK70.70948120
77NTRK10.70690608
78MAP3K90.70377723
79PRKD30.70353449
80NUAK10.70176701
81AURKB0.69410134
82ADRBK10.65457936
83MAP2K30.65096188
84LRRK20.64426989
85ZAP700.64348625
86MAPK110.64096556
87PIK3CG0.63601277
88CDK190.61590726
89PLK30.60989466
90MAPKAPK50.60218612
91MAP3K120.59885643
92SMG10.58461193
93PLK10.56979996
94GRK50.56214126
95CSF1R0.52432421
96ZAK0.51329342
97MAP2K20.51264825
98IRAK40.50885913
99ADRBK20.49542427
100RPS6KC10.49252779
101RPS6KL10.49252779
102ATR0.49187989
103CAMK2B0.49182452
104CLK10.48574116
105MAP2K70.47239514
106NEK10.45773009
107RPS6KA60.45639578
108YES10.45538649
109MAP3K80.45316173
110CSNK1G20.44335173
111EIF2AK20.43775475
112GSK3A0.43583945
113RAF10.43218218
114MAPKAPK20.43162894
115TNK20.42141636
116KIT0.42075469
117PRKCE0.41776235
118DDR20.41582603
119CDK11A0.41250263
120CAMK2D0.40645325
121MET0.40514999
122PAK20.40325882
123CSNK1G10.40005402
124BMX0.39400575
125BRSK10.39058872
126CDK180.38492653
127KSR10.38334697
128GRK10.38041652
129PRKD10.37715839
130PKN10.37065648
131STK100.36372668
132CDK150.36257954
133ROCK20.35886075
134CDK140.34946879
135CSNK2A10.34116020
136MAP4K10.32792418
137GRK60.32476615
138NEK20.31568778
139CSNK2A20.31563549
140ROCK10.31328969
141PLK20.30851900
142BMPR1B0.30372797
143TGFBR20.29845315
144EEF2K0.29418536
145CDC42BPA0.27435022
146INSR0.26504941
147IRAK20.26434260
148PASK0.26411991
149TXK0.25829864
150CAMK2G0.25514403
151PTK20.24673803
152IRAK10.24624978
153CDC70.24489498
154MAPK10.24128084
155TRPM70.22731391

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60362024
2Homologous recombination_Homo sapiens_hsa034404.46306186
3Proteasome_Homo sapiens_hsa030503.98872025
4RNA polymerase_Homo sapiens_hsa030203.74907992
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.13378816
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.96171369
7Spliceosome_Homo sapiens_hsa030402.57157096
8DNA replication_Homo sapiens_hsa030302.57120779
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44185177
10Oxidative phosphorylation_Homo sapiens_hsa001902.35410261
11Sulfur relay system_Homo sapiens_hsa041222.33288089
12Parkinsons disease_Homo sapiens_hsa050122.20540517
13Mismatch repair_Homo sapiens_hsa034301.93960029
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.87110513
15Pyrimidine metabolism_Homo sapiens_hsa002401.86437043
16* Fanconi anemia pathway_Homo sapiens_hsa034601.85637572
17Huntingtons disease_Homo sapiens_hsa050161.83145713
18TGF-beta signaling pathway_Homo sapiens_hsa043501.80258683
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75516168
20* Nucleotide excision repair_Homo sapiens_hsa034201.73092318
21Sulfur metabolism_Homo sapiens_hsa009201.73000083
22RNA transport_Homo sapiens_hsa030131.71029583
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69144635
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.68360526
25Non-homologous end-joining_Homo sapiens_hsa034501.68339188
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61739117
27Base excision repair_Homo sapiens_hsa034101.59514263
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54155456
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50057114
30Leishmaniasis_Homo sapiens_hsa051401.42567930
31p53 signaling pathway_Homo sapiens_hsa041151.41913136
32Epstein-Barr virus infection_Homo sapiens_hsa051691.31086876
33Cell cycle_Homo sapiens_hsa041101.30437814
34Basal transcription factors_Homo sapiens_hsa030221.27181985
35Alzheimers disease_Homo sapiens_hsa050101.26988076
36Other glycan degradation_Homo sapiens_hsa005111.26590983
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20242315
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18244845
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17608959
40N-Glycan biosynthesis_Homo sapiens_hsa005101.17453586
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13658555
42Arachidonic acid metabolism_Homo sapiens_hsa005901.10856814
43Cardiac muscle contraction_Homo sapiens_hsa042601.09847064
44Folate biosynthesis_Homo sapiens_hsa007901.04764242
45RNA degradation_Homo sapiens_hsa030181.02813240
46Protein export_Homo sapiens_hsa030601.01346767
47Purine metabolism_Homo sapiens_hsa002300.99404385
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98069589
49ECM-receptor interaction_Homo sapiens_hsa045120.93806175
50Peroxisome_Homo sapiens_hsa041460.93531836
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.92918081
52Shigellosis_Homo sapiens_hsa051310.92523675
53Lysosome_Homo sapiens_hsa041420.92480161
54Metabolic pathways_Homo sapiens_hsa011000.90788001
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87517648
56Collecting duct acid secretion_Homo sapiens_hsa049660.86515160
57Nicotine addiction_Homo sapiens_hsa050330.83289431
58Glutathione metabolism_Homo sapiens_hsa004800.76523918
59Systemic lupus erythematosus_Homo sapiens_hsa053220.72600059
60Herpes simplex infection_Homo sapiens_hsa051680.72516860
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72046523
62Pyruvate metabolism_Homo sapiens_hsa006200.69635940
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69069577
64Pentose phosphate pathway_Homo sapiens_hsa000300.69065601
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69014885
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65734726
67Carbon metabolism_Homo sapiens_hsa012000.65463122
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63768835
69Vibrio cholerae infection_Homo sapiens_hsa051100.63533575
70Proteoglycans in cancer_Homo sapiens_hsa052050.62475701
71HTLV-I infection_Homo sapiens_hsa051660.62279157
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61801584
73Malaria_Homo sapiens_hsa051440.61361815
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59733601
75One carbon pool by folate_Homo sapiens_hsa006700.58945113
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58819668
77Allograft rejection_Homo sapiens_hsa053300.58664076
78Melanoma_Homo sapiens_hsa052180.58529778
79Nitrogen metabolism_Homo sapiens_hsa009100.58051351
80Phagosome_Homo sapiens_hsa041450.55111731
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54815832
82HIF-1 signaling pathway_Homo sapiens_hsa040660.54395323
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53416438
84Focal adhesion_Homo sapiens_hsa045100.52368581
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51187213
86Hippo signaling pathway_Homo sapiens_hsa043900.51112610
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48704468
88Regulation of autophagy_Homo sapiens_hsa041400.48400772
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46576045
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45336946
91Small cell lung cancer_Homo sapiens_hsa052220.44290286
92Primary immunodeficiency_Homo sapiens_hsa053400.44262650
93Measles_Homo sapiens_hsa051620.43762265
94Biosynthesis of amino acids_Homo sapiens_hsa012300.43247166
95Legionellosis_Homo sapiens_hsa051340.41684438
96Hematopoietic cell lineage_Homo sapiens_hsa046400.41155348
97Bladder cancer_Homo sapiens_hsa052190.40767914
98Galactose metabolism_Homo sapiens_hsa000520.40228497
99Type I diabetes mellitus_Homo sapiens_hsa049400.39690565
100MicroRNAs in cancer_Homo sapiens_hsa052060.39391531
101Toxoplasmosis_Homo sapiens_hsa051450.39369284
102mRNA surveillance pathway_Homo sapiens_hsa030150.37749396
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37155126
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36929425
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35470444
106Apoptosis_Homo sapiens_hsa042100.35327358
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35261943
108Dilated cardiomyopathy_Homo sapiens_hsa054140.34834798
109Acute myeloid leukemia_Homo sapiens_hsa052210.34679501
110Viral carcinogenesis_Homo sapiens_hsa052030.34004335
111Tight junction_Homo sapiens_hsa045300.33519789
112Rheumatoid arthritis_Homo sapiens_hsa053230.33413461
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.33263252
114Salmonella infection_Homo sapiens_hsa051320.32803921
115Synaptic vesicle cycle_Homo sapiens_hsa047210.32329593
116Thyroid cancer_Homo sapiens_hsa052160.32121220
117Asthma_Homo sapiens_hsa053100.32011542
118Fatty acid elongation_Homo sapiens_hsa000620.29545230
119Gap junction_Homo sapiens_hsa045400.29199726
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29057125
121Rap1 signaling pathway_Homo sapiens_hsa040150.26782709
122Tyrosine metabolism_Homo sapiens_hsa003500.26674300
123Sphingolipid metabolism_Homo sapiens_hsa006000.26477020
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26316283
125Alcoholism_Homo sapiens_hsa050340.25887512
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25208355
127Antigen processing and presentation_Homo sapiens_hsa046120.24309095
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24085327
129Prion diseases_Homo sapiens_hsa050200.23479497
130Propanoate metabolism_Homo sapiens_hsa006400.23439134
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.23425093
132Viral myocarditis_Homo sapiens_hsa054160.23423803
133Fructose and mannose metabolism_Homo sapiens_hsa000510.23306537
134Ras signaling pathway_Homo sapiens_hsa040140.23172408
135B cell receptor signaling pathway_Homo sapiens_hsa046620.22447719
136Hepatitis B_Homo sapiens_hsa051610.22298604
137beta-Alanine metabolism_Homo sapiens_hsa004100.16423384
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.15182120
139Arginine and proline metabolism_Homo sapiens_hsa003300.14694000
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14555456
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.13680578
142Fatty acid metabolism_Homo sapiens_hsa012120.13619770
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13281575

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »