ERCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of organelle assembly (GO:1902116)7.82758003
2negative regulation of catenin import into nucleus (GO:0035414)7.41239365
3regulation of early endosome to late endosome transport (GO:2000641)6.55078963
4mitochondrial calcium ion homeostasis (GO:0051560)6.54059116
5regulation of cholesterol efflux (GO:0010874)5.95502592
6neuronal ion channel clustering (GO:0045161)5.91265158
7lysosome localization (GO:0032418)5.79043862
8organelle membrane fusion (GO:0090174)5.60341524
9regulation of receptor recycling (GO:0001919)5.33477671
10positive regulation of TOR signaling (GO:0032008)5.03749149
11positive regulation of B cell differentiation (GO:0045579)5.02028235
12negative regulation of fibroblast apoptotic process (GO:2000270)4.91239214
13execution phase of apoptosis (GO:0097194)4.73069444
14regulation of chromatin binding (GO:0035561)4.72941225
15peptidyl-arginine omega-N-methylation (GO:0035247)4.71202368
16rRNA transcription (GO:0009303)4.11233296
17negative regulation of epithelial to mesenchymal transition (GO:0010719)4.06032770
18endosome organization (GO:0007032)4.03846859
19peptidyl-arginine N-methylation (GO:0035246)3.99781808
20peptidyl-arginine methylation (GO:0018216)3.99781808
21mitotic chromosome condensation (GO:0007076)3.98784792
22proline biosynthetic process (GO:0006561)3.96402186
23negative regulation of RNA splicing (GO:0033119)3.94375296
24L-serine metabolic process (GO:0006563)3.93966496
25establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.84768066
26mitochondrion transport along microtubule (GO:0047497)3.84768066
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.80747622
28protein retention in ER lumen (GO:0006621)3.77087622
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.76660335
30seminiferous tubule development (GO:0072520)3.66778298
31I-kappaB phosphorylation (GO:0007252)3.66425238
32semaphorin-plexin signaling pathway (GO:0071526)3.65596330
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62268428
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.56271393
35negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.54109678
36paraxial mesoderm development (GO:0048339)3.53685763
37convergent extension (GO:0060026)3.53630887
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50394623
39pre-miRNA processing (GO:0031054)3.49095148
40ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.45853649
41histone arginine methylation (GO:0034969)3.45313088
42regulation of catenin import into nucleus (GO:0035412)3.45138648
43positive regulation of histone deacetylation (GO:0031065)3.40149724
44DNA strand elongation (GO:0022616)3.40000133
45sialylation (GO:0097503)3.38707247
46establishment of integrated proviral latency (GO:0075713)3.36854595
47regulation of sterol transport (GO:0032371)3.36407306
48regulation of cholesterol transport (GO:0032374)3.36407306
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31472932
50mitotic sister chromatid segregation (GO:0000070)3.23884921
51nuclear envelope reassembly (GO:0031468)3.22591474
52mitotic nuclear envelope reassembly (GO:0007084)3.22591474
53nucleosome disassembly (GO:0006337)3.18766354
54protein-DNA complex disassembly (GO:0032986)3.18766354
55peptidyl-lysine dimethylation (GO:0018027)3.17842832
56formation of translation preinitiation complex (GO:0001731)3.16514146
57RNA stabilization (GO:0043489)3.08109915
58mRNA stabilization (GO:0048255)3.08109915
59establishment of viral latency (GO:0019043)3.07862143
60protein maturation by protein folding (GO:0022417)3.07209076
61endoplasmic reticulum organization (GO:0007029)3.07204398
62* spinal cord development (GO:0021510)3.05735963
63chromatin assembly (GO:0031497)3.05165513
64Leydig cell differentiation (GO:0033327)3.03725202
65COPI coating of Golgi vesicle (GO:0048205)3.03553824
66Golgi transport vesicle coating (GO:0048200)3.03553824
67DNA replication initiation (GO:0006270)3.00679665
68negative regulation of histone methylation (GO:0031061)3.00617048
69regulation of translational fidelity (GO:0006450)3.00138858
70cerebral cortex neuron differentiation (GO:0021895)2.93073565
71positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.92479845
72protein complex localization (GO:0031503)2.92394879
73gene silencing by RNA (GO:0031047)2.91969504
74stress granule assembly (GO:0034063)2.91815900
75establishment of mitochondrion localization (GO:0051654)2.91519081
76sister chromatid segregation (GO:0000819)2.88793966
77ribosomal small subunit biogenesis (GO:0042274)2.87208042
78chromosome condensation (GO:0030261)2.87172971
79cell-substrate adherens junction assembly (GO:0007045)2.86197461
80focal adhesion assembly (GO:0048041)2.86197461
81regulation of gamma-delta T cell differentiation (GO:0045586)2.85525609
82viral transcription (GO:0019083)2.84907170
83lytic vacuole organization (GO:0080171)2.84834385
84lysosome organization (GO:0007040)2.84834385
85adherens junction assembly (GO:0034333)2.84320815
86calcium ion import (GO:0070509)2.83387434
87negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82974330
88proline metabolic process (GO:0006560)2.81846640
89regulation of B cell differentiation (GO:0045577)2.80812835
90DNA unwinding involved in DNA replication (GO:0006268)2.79543338
91maturation of SSU-rRNA (GO:0030490)2.77891626
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.77685105
93T-helper cell differentiation (GO:0042093)2.77685105
94positive regulation of protein deacetylation (GO:0090312)2.77401447
95negative regulation of cell size (GO:0045792)2.76103247
96regulation of translational termination (GO:0006449)2.75725620
97establishment of apical/basal cell polarity (GO:0035089)2.74721391
98mitotic metaphase plate congression (GO:0007080)2.72482388
99gene silencing (GO:0016458)2.71384950
100folic acid-containing compound biosynthetic process (GO:0009396)2.70193872
101translational termination (GO:0006415)2.69738488
102DNA damage response, detection of DNA damage (GO:0042769)2.69305896
103notochord development (GO:0030903)2.65740881
104protein insertion into membrane (GO:0051205)2.65530580
105G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.65397099
106spliceosomal tri-snRNP complex assembly (GO:0000244)2.65163432
107negative regulation of DNA-templated transcription, elongation (GO:0032785)2.64273207
108nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.63728453
109folic acid metabolic process (GO:0046655)2.63588217
110regulation of DNA methylation (GO:0044030)2.63144927
111cell-cell junction maintenance (GO:0045217)2.62338592
112translational elongation (GO:0006414)2.61635439
113regulation of posttranscriptional gene silencing (GO:0060147)2.58529003
114regulation of gene silencing by miRNA (GO:0060964)2.58529003
115regulation of gene silencing by RNA (GO:0060966)2.58529003
116DNA strand elongation involved in DNA replication (GO:0006271)2.58408235
117nuclear pore complex assembly (GO:0051292)2.58070866
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57782189
119negative regulation of mRNA processing (GO:0050686)2.57678499
120IMP biosynthetic process (GO:0006188)2.57419891
121telomere maintenance via semi-conservative replication (GO:0032201)2.56222808
122definitive hemopoiesis (GO:0060216)2.55180869
123ribosomal small subunit assembly (GO:0000028)2.54356651
124heterochromatin organization (GO:0070828)2.53136535
125positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51835454
126protein localization to kinetochore (GO:0034501)2.50267166
127regulation of histone H3-K9 methylation (GO:0051570)2.50049002
128response to dietary excess (GO:0002021)2.49094109
129protein localization to chromosome, centromeric region (GO:0071459)2.48937367
130maternal placenta development (GO:0001893)2.48708479
131DNA synthesis involved in DNA repair (GO:0000731)2.48166444
132alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47185083
133alpha-beta T cell activation involved in immune response (GO:0002287)2.47185083
134T cell differentiation involved in immune response (GO:0002292)2.47185083
135* DNA duplex unwinding (GO:0032508)2.47153999
136synaptonemal complex assembly (GO:0007130)2.46746921
137phosphatidylinositol dephosphorylation (GO:0046856)2.46314724
138neural tube development (GO:0021915)2.45166042
139nuclear pore organization (GO:0006999)2.44243496
140response to food (GO:0032094)2.43835888
141cochlea morphogenesis (GO:0090103)2.43440308
142modified amino acid transport (GO:0072337)2.43306775
143nucleobase biosynthetic process (GO:0046112)2.43195106
144serine family amino acid biosynthetic process (GO:0009070)2.42045058
145mitotic nuclear envelope disassembly (GO:0007077)2.41678263
146DNA replication checkpoint (GO:0000076)2.41350457
147DNA packaging (GO:0006323)2.41165889
148Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.40834773
149pentose-phosphate shunt (GO:0006098)2.40834670
150retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.40036544
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.38981090
152epithelial cell-cell adhesion (GO:0090136)2.38780575
153DNA topological change (GO:0006265)2.37337372
154activation of MAPKKK activity (GO:0000185)2.36994026
155apoptotic process involved in morphogenesis (GO:0060561)2.35735253
156* DNA conformation change (GO:0071103)2.33919176
157* DNA geometric change (GO:0032392)2.32286289
158pore complex assembly (GO:0046931)2.31651672
159nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.31615373
160establishment or maintenance of monopolar cell polarity (GO:0061339)2.31379104
161establishment of monopolar cell polarity (GO:0061162)2.31379104
162chromatin assembly or disassembly (GO:0006333)2.31260973
163ribonucleoprotein complex biogenesis (GO:0022613)2.30872137
164DNA strand renaturation (GO:0000733)2.29434473
165ATP-dependent chromatin remodeling (GO:0043044)2.28733736
166regulation of establishment of planar polarity (GO:0090175)2.28442202
167base-excision repair (GO:0006284)2.28159188
168positive regulation of DNA-dependent DNA replication (GO:2000105)2.27923096
169endothelial cell morphogenesis (GO:0001886)2.27409987
170nuclear envelope disassembly (GO:0051081)2.27174776
171membrane disassembly (GO:0030397)2.27174776
172ncRNA 3-end processing (GO:0043628)2.26707729
173regulation of cholesterol esterification (GO:0010872)11.9053534
174mitochondrial calcium ion transport (GO:0006851)11.1854031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.09521646
2MYC_22102868_ChIP-Seq_BL_Human4.03091918
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.60045299
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.52856475
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.43793207
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99720764
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94192971
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93458030
9VDR_21846776_ChIP-Seq_THP-1_Human2.67481285
10KDM2B_26808549_Chip-Seq_DND41_Human2.44226096
11LXR_22292898_ChIP-Seq_THP-1_Human2.34480079
12CIITA_25753668_ChIP-Seq_RAJI_Human2.31280960
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.28119367
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.25115156
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19821929
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15454908
17TCF7_22412390_ChIP-Seq_EML_Mouse2.14591033
18IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13908463
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09213007
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05742009
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02710676
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02528695
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00639518
24FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.96962090
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89313521
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87045332
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85708557
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85022574
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82412058
30P68_20966046_ChIP-Seq_HELA_Human1.78128785
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77833216
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76010675
33MAF_26560356_Chip-Seq_TH1_Human1.74210536
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71648243
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.67403811
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65342998
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.64466971
38TP53_22127205_ChIP-Seq_IMR90_Human1.62392920
39ZNF263_19887448_ChIP-Seq_K562_Human1.62374606
40RACK7_27058665_Chip-Seq_MCF-7_Human1.61121162
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60516367
42CLOCK_20551151_ChIP-Seq_293T_Human1.57267653
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57143853
44CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.55513489
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.53789240
46* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53670721
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51911037
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50894735
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50790145
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.49777583
51TTF2_22483619_ChIP-Seq_HELA_Human1.47921932
52GABP_19822575_ChIP-Seq_HepG2_Human1.47616030
53UTX_26944678_Chip-Seq_JUKART_Human1.47279200
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44997363
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44127630
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42648579
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.42389830
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40136052
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37575538
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37183212
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37012871
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.36601054
63BCL6_27268052_Chip-Seq_Bcells_Human1.34405542
64BCOR_27268052_Chip-Seq_Bcells_Human1.34346893
65KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33928781
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.33821677
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33738735
68DCP1A_22483619_ChIP-Seq_HELA_Human1.31875098
69SCL_19346495_ChIP-Seq_HPC-7_Human1.29401068
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29179348
71NCOR1_26117541_ChIP-Seq_K562_Human1.28686152
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.28547295
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28251513
74PKCTHETA_26484144_Chip-Seq_BREAST_Human1.27854387
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27332986
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.26317757
77ATF3_27146783_Chip-Seq_COLON_Human1.24914263
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24285897
79KDM2B_26808549_Chip-Seq_K562_Human1.23832221
80CREB1_26743006_Chip-Seq_LNCaP_Human1.22824635
81E2F1_20622854_ChIP-Seq_HELA_Human1.21776998
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20707266
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20377303
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19910377
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19487694
86CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18919822
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18287279
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18229936
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17802935
90SMC4_20622854_ChIP-Seq_HELA_Human1.15971794
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15495663
92PHF8_20622854_ChIP-Seq_HELA_Human1.14894065
93SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13198122
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13051023
95FOXP1_21924763_ChIP-Seq_HESCs_Human1.12854511
96* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12495928
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.12088506
98TET1_21451524_ChIP-Seq_MESCs_Mouse1.11803527
99XRN2_22483619_ChIP-Seq_HELA_Human1.11581444
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11266502
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10496751
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10379218
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.10309724
104SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10247458
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10178506
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10151853
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09428822
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09386853
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08298953
110P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07279892
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06277557
112NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05932128
113MAF_26560356_Chip-Seq_TH2_Human1.04699905
114YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03992123
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02766980
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02340726
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01922800
118* SA1_27219007_Chip-Seq_ERYTHROID_Human1.01312030
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01080737
120* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01022775
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00996787
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.00451757
123CTCF_21964334_Chip-Seq_Bcells_Human1.00132291
124SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99874593
125TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99038170
126MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98991008
127* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98700706
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98504232
129CHD1_26751641_Chip-Seq_LNCaP_Human0.98496620
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98403830
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98204019
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97967669
133KDM5A_27292631_Chip-Seq_BREAST_Human0.97886586
134TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96374441
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96024679
136RUNX1_27514584_Chip-Seq_MCF-7_Human0.93884782
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.93732045
138VDR_24763502_ChIP-Seq_THP-1_Human0.93229651
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92724170
140TFEB_21752829_ChIP-Seq_HELA_Human0.92712836
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91418331
142CTCF_27219007_Chip-Seq_Bcells_Human0.89484363
143KAP1_27257070_Chip-Seq_ESCs_Mouse0.89360588
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89007664
145FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88622899
146EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86992840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.73718656
2MP0003878_abnormal_ear_physiology6.73718656
3MP0002102_abnormal_ear_morphology5.44375827
4MP0005623_abnormal_meninges_morphology3.98567276
5MP0003879_abnormal_hair_cell2.73828561
6MP0003705_abnormal_hypodermis_morpholog2.64017342
7MP0008438_abnormal_cutaneous_collagen2.58140716
8MP0003303_peritoneal_inflammation2.46047821
9MP0003300_gastrointestinal_ulcer2.40851281
10MP0008932_abnormal_embryonic_tissue2.35379450
11MP0004272_abnormal_basement_membrane2.23693730
12MP0003866_abnormal_defecation2.20374516
13MP0003111_abnormal_nucleus_morphology2.06928397
14MP0010234_abnormal_vibrissa_follicle2.05822733
15MP0003385_abnormal_body_wall2.02669540
16MP0008961_abnormal_basal_metabolism2.02614681
17MP0005076_abnormal_cell_differentiation1.98119316
18MP0009384_cardiac_valve_regurgitation1.97852398
19MP0010352_gastrointestinal_tract_polyps1.84536952
20MP0003119_abnormal_digestive_system1.79130580
21MP0003942_abnormal_urinary_system1.74835782
22MP0001485_abnormal_pinna_reflex1.74207485
23MP0004858_abnormal_nervous_system1.74121647
24MP0000749_muscle_degeneration1.72325317
25MP0009278_abnormal_bone_marrow1.72079255
26MP0000750_abnormal_muscle_regeneration1.68768312
27MP0005551_abnormal_eye_electrophysiolog1.68518652
28MP0009840_abnormal_foam_cell1.64370383
29MP0002092_abnormal_eye_morphology1.63023032
30MP0002254_reproductive_system_inflammat1.59960898
31MP0001730_embryonic_growth_arrest1.59786488
32MP0004197_abnormal_fetal_growth/weight/1.58589158
33MP0002249_abnormal_larynx_morphology1.54532913
34MP0006292_abnormal_olfactory_placode1.52875745
35MP0000049_abnormal_middle_ear1.50793671
36MP0003937_abnormal_limbs/digits/tail_de1.50675224
37MP0001299_abnormal_eye_distance/1.49869071
38MP0004808_abnormal_hematopoietic_stem1.49798372
39MP0003077_abnormal_cell_cycle1.47367383
40MP0010094_abnormal_chromosome_stability1.46181135
41MP0000350_abnormal_cell_proliferation1.46145567
42MP0009053_abnormal_anal_canal1.45022892
43MP0001849_ear_inflammation1.42633642
44MP0000534_abnormal_ureter_morphology1.41470819
45MP0008995_early_reproductive_senescence1.38672528
46MP0001661_extended_life_span1.38059504
47MP0000762_abnormal_tongue_morphology1.35302102
48MP0000566_synostosis1.34352704
49MP0000465_gastrointestinal_hemorrhage1.33818895
50MP0000678_abnormal_parathyroid_gland1.31828545
51MP0005380_embryogenesis_phenotype1.31706820
52MP0001672_abnormal_embryogenesis/_devel1.31706820
53MP0003941_abnormal_skin_development1.29687493
54MP0004957_abnormal_blastocyst_morpholog1.25935881
55MP0003693_abnormal_embryo_hatching1.24324207
56MP0002085_abnormal_embryonic_tissue1.24113984
57* MP0002080_prenatal_lethality1.22167427
58MP0002088_abnormal_embryonic_growth/wei1.21164333
59MP0010030_abnormal_orbit_morphology1.19518985
60MP0001348_abnormal_lacrimal_gland1.19377432
61MP0003984_embryonic_growth_retardation1.18634971
62MP0003566_abnormal_cell_adhesion1.18585410
63MP0001697_abnormal_embryo_size1.16481951
64MP0004742_abnormal_vestibular_system1.16132847
65MP0003755_abnormal_palate_morphology1.15201143
66MP0002877_abnormal_melanocyte_morpholog1.12706248
67MP0008007_abnormal_cellular_replicative1.12624354
68MP0002282_abnormal_trachea_morphology1.12582672
69MP0002697_abnormal_eye_size1.12369432
70MP0002086_abnormal_extraembryonic_tissu1.11782439
71MP0002089_abnormal_postnatal_growth/wei1.10834923
72MP0009250_abnormal_appendicular_skeleto1.10117058
73MP0002653_abnormal_ependyma_morphology1.08557928
74MP0002111_abnormal_tail_morphology1.08328554
75MP0002084_abnormal_developmental_patter1.06467412
76MP0001324_abnormal_eye_pigmentation1.06130906
77* MP0008058_abnormal_DNA_repair1.06124292
78MP0005253_abnormal_eye_physiology1.05402910
79* MP0000003_abnormal_adipose_tissue1.04765026
80MP0001879_abnormal_lymphatic_vessel1.04419855
81MP0000537_abnormal_urethra_morphology1.04419010
82MP0002116_abnormal_craniofacial_bone1.03793077
83MP0006072_abnormal_retinal_apoptosis1.03026999
84MP0003279_aneurysm1.00553394
85MP0000703_abnormal_thymus_morphology1.00153597
86MP0004133_heterotaxia1.00075284
87* MP0010307_abnormal_tumor_latency0.99311440
88MP0005365_abnormal_bile_salt0.99216625
89MP0005391_vision/eye_phenotype0.99096545
90MP0001545_abnormal_hematopoietic_system0.98683988
91MP0005397_hematopoietic_system_phenotyp0.98683988
92MP0005023_abnormal_wound_healing0.98295810
93MP0001835_abnormal_antigen_presentation0.96632080
94MP0000358_abnormal_cell_content/0.96583526
95MP0001286_abnormal_eye_development0.96560910
96* MP0002019_abnormal_tumor_incidence0.96503808
97MP0003123_paternal_imprinting0.96214122
98* MP0002114_abnormal_axial_skeleton0.95504206
99MP0000432_abnormal_head_morphology0.95265907
100MP0000462_abnormal_digestive_system0.93717242
101MP0003718_maternal_effect0.89095451
102MP0000759_abnormal_skeletal_muscle0.88431347
103MP0004233_abnormal_muscle_weight0.88362808
104MP0010368_abnormal_lymphatic_system0.88208268
105* MP0000313_abnormal_cell_death0.87210273
106MP0002398_abnormal_bone_marrow0.86811695
107MP0009672_abnormal_birth_weight0.86519105
108MP0000428_abnormal_craniofacial_morphol0.86469592
109MP0004087_abnormal_muscle_fiber0.86456978
110MP0000751_myopathy0.84920272
111MP0000747_muscle_weakness0.84202805
112MP0003115_abnormal_respiratory_system0.83514428
113MP0003763_abnormal_thymus_physiology0.83490841
114MP0003315_abnormal_perineum_morphology0.83380523
115MP0002233_abnormal_nose_morphology0.83029485
116MP0010630_abnormal_cardiac_muscle0.80732452
117MP0009697_abnormal_copulation0.80562137
118MP0003890_abnormal_embryonic-extraembry0.80143954
119MP0002932_abnormal_joint_morphology0.80004206
120MP0001800_abnormal_humoral_immune0.79771089
121MP0001346_abnormal_lacrimal_gland0.79362494
122MP0002396_abnormal_hematopoietic_system0.79263409
123MP0000733_abnormal_muscle_development0.79244295
124MP0004185_abnormal_adipocyte_glucose0.79022029
125* MP0002081_perinatal_lethality0.78778294
126MP0002210_abnormal_sex_determination0.78406428
127MP0003567_abnormal_fetal_cardiomyocyte0.77869249
128MP0005197_abnormal_uvea_morphology0.77758331
129MP0000569_abnormal_digit_pigmentation0.77409913
130MP0009333_abnormal_splenocyte_physiolog0.76642598
131MP0002177_abnormal_outer_ear0.76360916
132MP0009703_decreased_birth_body0.76122719
133MP0002060_abnormal_skin_morphology0.75973610
134MP0003935_abnormal_craniofacial_develop0.75556590
135MP0001340_abnormal_eyelid_morphology0.75225001
136MP0002269_muscular_atrophy0.74974308
137MP0001293_anophthalmia0.73396553
138* MP0002722_abnormal_immune_system0.71335711
139MP0000685_abnormal_immune_system0.70411577
140* MP0001145_abnormal_male_reproductive0.68766522
141MP0004134_abnormal_chest_morphology0.67341572
142* MP0000689_abnormal_spleen_morphology0.67303768
143MP0001929_abnormal_gametogenesis0.65846993
144MP0002796_impaired_skin_barrier0.63759907
145MP0003091_abnormal_cell_migration0.62626019
146MP0002405_respiratory_system_inflammati0.62582037
147MP0002970_abnormal_white_adipose0.59814687
148MP0001919_abnormal_reproductive_system0.59238406
149MP0001915_intracranial_hemorrhage0.58739966
150MP0005257_abnormal_intraocular_pressure0.58584667
151MP0000716_abnormal_immune_system0.58430933
152MP0003861_abnormal_nervous_system0.58020854
153MP0003283_abnormal_digestive_organ0.56267564
154MP0008770_decreased_survivor_rate0.56151570
155MP0002925_abnormal_cardiovascular_devel0.55731353

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)5.95816618
2Male infertility (HP:0003251)5.45154909
3Cone-rod dystrophy (HP:0000548)4.90780434
4Subacute progressive viral hepatitis (HP:0006572)4.90629531
5Premature rupture of membranes (HP:0001788)4.33840933
6Conjunctival hamartoma (HP:0100780)3.72528026
7Protrusio acetabuli (HP:0003179)3.70867838
8Hamartoma of the eye (HP:0010568)3.40298011
9Angiofibromas (HP:0010615)3.36051077
10Adenoma sebaceum (HP:0009720)3.36051077
11Ulnar bowing (HP:0003031)3.33898458
12Deep palmar crease (HP:0006191)3.22000738
13Hyperacusis (HP:0010780)3.19983890
14Stomach cancer (HP:0012126)3.19639422
15Failure to thrive in infancy (HP:0001531)3.14781374
16Biliary tract neoplasm (HP:0100574)3.14756661
17Macular degeneration (HP:0000608)3.13830325
18Large earlobe (HP:0009748)3.11201671
19Generalized aminoaciduria (HP:0002909)3.10840290
20Difficulty climbing stairs (HP:0003551)3.09764080
21Cerebellar dysplasia (HP:0007033)3.06050061
22Poor eye contact (HP:0000817)3.05441550
23Retinal dysplasia (HP:0007973)3.04665167
24Elfin facies (HP:0004428)2.95389984
25Shallow orbits (HP:0000586)2.92056058
26Abnormality of the costochondral junction (HP:0000919)2.89279488
27Viral hepatitis (HP:0006562)2.88772449
28Ependymoma (HP:0002888)2.85408880
29Abnormality of dentin (HP:0010299)2.81116367
30Cerebral aneurysm (HP:0004944)2.80235979
31Pseudobulbar signs (HP:0002200)2.80026108
32Impaired social interactions (HP:0000735)2.79368806
33Abnormal social behavior (HP:0012433)2.79368806
34Disproportionate tall stature (HP:0001519)2.74826209
35Abnormality of the fingertips (HP:0001211)2.70469853
36Germ cell neoplasia (HP:0100728)2.67314083
37High anterior hairline (HP:0009890)2.63073305
38Megalocornea (HP:0000485)2.56962681
39Abnormality of cells of the erythroid lineage (HP:0012130)2.55515279
40Biconcave vertebral bodies (HP:0004586)2.53715461
41Neonatal respiratory distress (HP:0002643)2.53074626
42Abnormal number of erythroid precursors (HP:0012131)2.52919545
43Buphthalmos (HP:0000557)2.52197398
44Micronodular cirrhosis (HP:0001413)2.51525792
45Ankle contracture (HP:0006466)2.50865860
46Visceral angiomatosis (HP:0100761)2.47511090
47Megalencephaly (HP:0001355)2.45914784
48Long palpebral fissure (HP:0000637)2.39811809
49Leiomyosarcoma (HP:0100243)2.39154906
50Uterine leiomyosarcoma (HP:0002891)2.39154906
51Spinal rigidity (HP:0003306)2.39039059
52Recurrent corneal erosions (HP:0000495)2.38152730
53Broad distal phalanx of finger (HP:0009836)2.36787027
54Abnormality of the lower motor neuron (HP:0002366)2.36629029
55Congenital glaucoma (HP:0001087)2.36298283
56Generalized hypotonia (HP:0001290)2.35731291
57Hemangiomatosis (HP:0007461)2.34913711
58Arnold-Chiari malformation (HP:0002308)2.30974442
59Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.30215150
60Overgrowth (HP:0001548)2.29055756
61Verrucae (HP:0200043)2.28484433
62Papilloma (HP:0012740)2.28484433
63Hypoplasia of the pons (HP:0012110)2.27473532
64Premature skin wrinkling (HP:0100678)2.27182884
65Sandal gap (HP:0001852)2.26078517
66Increased density of long bones (HP:0006392)2.24871793
67Hepatocellular carcinoma (HP:0001402)2.24585936
68Insomnia (HP:0100785)2.21778999
69Malignant gastrointestinal tract tumors (HP:0006749)2.19588503
70Gastrointestinal carcinoma (HP:0002672)2.19588503
71Bladder diverticulum (HP:0000015)2.19581480
72Nephroblastoma (Wilms tumor) (HP:0002667)2.18867957
73Distal upper limb amyotrophy (HP:0007149)2.18594833
74Upper limb amyotrophy (HP:0009129)2.18594833
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15903679
76Retinal atrophy (HP:0001105)2.14896006
77Abnormality of the calcaneus (HP:0008364)2.14718235
78Fibrous tissue neoplasm (HP:0012316)2.13244951
79Hyponatremia (HP:0002902)2.13220759
80Unilateral renal agenesis (HP:0000122)2.13220573
81Type II lissencephaly (HP:0007260)2.11667327
82Selective tooth agenesis (HP:0001592)2.09812551
83Reticulocytopenia (HP:0001896)2.09651907
84Coronal craniosynostosis (HP:0004440)2.09513255
85Fibroma (HP:0010614)2.08755448
86Hypophosphatemic rickets (HP:0004912)2.08382274
87Renovascular hypertension (HP:0100817)2.07313168
88Intellectual disability, profound (HP:0002187)2.05628355
89Fatigue (HP:0012378)2.04053508
90Aplasia involving bones of the extremities (HP:0009825)2.02787927
91Aplasia involving bones of the upper limbs (HP:0009823)2.02787927
92Aplasia of the phalanges of the hand (HP:0009802)2.02787927
93Trismus (HP:0000211)2.02503929
94Meningioma (HP:0002858)2.01343114
95Trigonocephaly (HP:0000243)2.00352209
96Breast carcinoma (HP:0003002)1.98623976
97Abnormality of the astrocytes (HP:0100707)1.98527513
98Astrocytoma (HP:0009592)1.98527513
99Achilles tendon contracture (HP:0001771)1.96577479
100Deviation of the thumb (HP:0009603)1.96384438
101Cutis marmorata (HP:0000965)1.96342410
102Embryonal renal neoplasm (HP:0011794)1.96227171
103Duplication of thumb phalanx (HP:0009942)1.95832078
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95500104
105Absent epiphyses (HP:0010577)1.95500104
106Congenital stationary night blindness (HP:0007642)1.94680055
107Bowed forearm bones (HP:0003956)1.93332278
108Bowing of the arm (HP:0006488)1.93332278
109Patellar dislocation (HP:0002999)1.93007508
110Abnormality of sulfur amino acid metabolism (HP:0004339)1.92164743
111Neoplasm of the rectum (HP:0100743)1.91569693
112Abnormality of the pons (HP:0007361)1.91284424
113Hand muscle atrophy (HP:0009130)1.90771102
114Renal duplication (HP:0000075)1.90505973
115Midface retrusion (HP:0011800)1.90103584
116Abnormal biliary tract morphology (HP:0012440)1.89760153
117Proximal placement of thumb (HP:0009623)1.89730075
118Transitional cell carcinoma of the bladder (HP:0006740)1.89548455
119Abnormal drinking behavior (HP:0030082)1.89282094
120Polydipsia (HP:0001959)1.89282094
121Progressive visual loss (HP:0000529)1.89113166
122Flat cornea (HP:0007720)1.88925967
123Delayed puberty (HP:0000823)1.88181521
124Broad thumb (HP:0011304)1.85198356
125Cortical dysplasia (HP:0002539)1.83725353
126Short nail (HP:0001799)1.83449788
127Lower limb asymmetry (HP:0100559)1.82909693
128Thin ribs (HP:0000883)1.82663182
129Turricephaly (HP:0000262)1.82652273
130Abnormality of the diencephalon (HP:0010662)1.82069559
131Hypopigmentation of the fundus (HP:0007894)1.81119494
132Cafe-au-lait spot (HP:0000957)1.81068870
133Genu recurvatum (HP:0002816)1.80559385
134Blue sclerae (HP:0000592)1.80323279
135Abnormality of sodium homeostasis (HP:0010931)1.79986164
136Anal stenosis (HP:0002025)1.79877955
137Progressive muscle weakness (HP:0003323)1.78591871
138Broad metatarsal (HP:0001783)1.78425926
139Neoplasm of the heart (HP:0100544)1.77861669
140Rectal prolapse (HP:0002035)1.77402112
141Partial duplication of thumb phalanx (HP:0009944)1.77380872
142Glossoptosis (HP:0000162)1.75121433
143Fragile skin (HP:0001030)1.73771492
144Increased nuchal translucency (HP:0010880)1.72470545
145Bowel diverticulosis (HP:0005222)1.72194754
146Dysmetric saccades (HP:0000641)1.71416942
147Multiple lipomas (HP:0001012)1.71239891
148Mitral regurgitation (HP:0001653)1.70657931
149Bicuspid aortic valve (HP:0001647)1.70550860
150Intestinal polyp (HP:0005266)1.70080694
151Bladder carcinoma (HP:0002862)1.70053340
152Bladder neoplasm (HP:0009725)1.70053340
153Cervical subluxation (HP:0003308)1.69911550
154Bronchomalacia (HP:0002780)1.69636536
155Spastic diplegia (HP:0001264)1.69509830
156Overriding aorta (HP:0002623)1.69142281
157Abnormality of reticulocytes (HP:0004312)1.69073774
158Abnormality of the musculature of the hand (HP:0001421)1.68750096
159Broad phalanges of the hand (HP:0009768)1.68561668
160Exocrine pancreatic insufficiency (HP:0001738)1.68028706
161Abnormal number of incisors (HP:0011064)1.68006219
162Enlarged penis (HP:0000040)1.67995360
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.67010824
164Truncus arteriosus (HP:0001660)1.66853210
165Partial duplication of the phalanx of hand (HP:0009999)1.66498777
166Stereotypic behavior (HP:0000733)1.66166520
167Vertebral compression fractures (HP:0002953)1.65875476
168Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65771003
169Hypoplasia of the brainstem (HP:0002365)1.65771003
170Generalized hyperpigmentation (HP:0007440)1.65496078
171Elbow flexion contracture (HP:0002987)1.65146134
172Abnormality of the Achilles tendon (HP:0005109)1.65061855
173Facial cleft (HP:0002006)1.64568153
174Vertebral arch anomaly (HP:0008438)1.64457866
175Intestinal polyposis (HP:0200008)1.64386049
176Abnormal gallbladder physiology (HP:0012438)1.64330630
177Cholecystitis (HP:0001082)1.64330630
178Choanal stenosis (HP:0000452)1.63837164
179Slender long bone (HP:0003100)1.63117967
180Congenital hip dislocation (HP:0001374)1.62925865
181Skull defect (HP:0001362)1.62654029
182Broad finger (HP:0001500)1.61703814
183Long toe (HP:0010511)1.60908933
184Pointed chin (HP:0000307)1.60871096
185Long eyelashes (HP:0000527)1.60329743
186Neoplasm of the small intestine (HP:0100833)1.60225063
187Mitral valve prolapse (HP:0001634)1.58460258
188Abnormality of the acetabulum (HP:0003170)1.58298818
189Testicular neoplasm (HP:0010788)1.57435248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK24.59680171
2TAOK14.57873506
3SMG13.79082782
4TRIB33.49603073
5PKN23.47258624
6EEF2K3.41612928
7PINK13.38617880
8MAP3K103.15943608
9BUB12.64392934
10BRAF2.55857571
11VRK22.55062825
12NEK22.34373782
13NTRK12.20234887
14MAP3K82.15997184
15MAP4K12.13515339
16MAP2K22.00704218
17CDK121.91253910
18IRAK31.67989816
19ERN11.63886516
20BRD41.56758412
21RIPK11.53519510
22CHEK21.41910857
23TTN1.36172647
24SRPK11.35949945
25PTK61.32147060
26ALK1.31708782
27ICK1.28462474
28DMPK1.26009298
29MET1.25296365
30LIMK11.24902931
31LATS21.24481342
32TGFBR11.24092678
33FGFR41.17326619
34TYRO31.14344615
35RPS6KB21.13808748
36PAK21.13792193
37STK161.11636302
38KDR1.10168507
39TAF11.08573212
40CDK81.07835285
41EPHB11.04214262
42TNK21.03907578
43INSRR1.02862061
44MTOR1.02755395
45GRK61.02573900
46SIK21.02031790
47ARAF0.97773887
48SCYL20.96971890
49LRRK20.96695389
50LMTK20.94298506
51SIK10.94286857
52CAMK1D0.91233013
53TTK0.90246076
54STK100.89154144
55BRSK10.88785018
56MAP3K90.87632355
57MKNK20.85606942
58CDC70.84812862
59CLK10.84016790
60ERBB40.81339245
61TAOK20.81299487
62CDK40.81199105
63AURKB0.79792174
64CDK11A0.79631662
65PRKD20.79491545
66STK40.76731517
67NEK10.76425504
68PLK10.76135607
69LATS10.72710570
70CDK150.72138149
71PASK0.72007633
72PAK40.71546999
73RPS6KA20.70828088
74PRKD30.70108312
75RPS6KA40.68362418
76EPHB20.67253024
77CAMK1G0.66547620
78PDK10.66109136
79CHEK10.66003161
80CDK180.65353906
81CDK70.64271274
82STK30.63989844
83PDGFRA0.63669227
84MAP3K70.63379905
85ERBB20.62720136
86FLT30.62636143
87TSSK60.62185653
88AKT20.61713430
89PAK10.61238378
90MARK20.60871161
91TGFBR20.60437346
92PIM20.59807363
93FES0.59054875
94BCKDK0.58761234
95STK110.58738298
96CDK90.58618779
97DYRK20.57378990
98BMX0.57362891
99CDK10.56710508
100AURKA0.56561335
101CDK140.55944240
102DYRK30.55825661
103ZAP700.55816964
104DAPK10.54266062
105DAPK30.54180919
106HCK0.53785155
107PLK30.53042161
108PRKG20.52888721
109PDPK10.52202269
110CDK190.51688589
111CDK60.50514195
112MOS0.49584561
113KSR20.48967895
114CDC42BPA0.48270462
115WNK40.48204065
116CHUK0.48202097
117MAP3K110.46866422
118MARK30.46402381
119HIPK20.46392002
120FGFR10.46206319
121MARK10.45698527
122PDK40.44226919
123PDK30.44226919
124KSR10.43800697
125ILK0.42902513
126VRK10.42506868
127EPHA20.42179802
128MAPK110.41746733
129RAF10.40803891
130WEE10.40688462
131RPS6KA10.40560729
132ATR0.40559369
133PRKCH0.39270512
134MAP2K30.38818941
135RPS6KC10.38356267
136RPS6KL10.38356267
137NME20.38175021
138MELK0.37691893
139MKNK10.35470541
140PTK20.34893670
141CSK0.34708732
142CDK20.34089416
143PRKCI0.33803795
144CSF1R0.32442148
145DYRK1B0.32306371
146JAK20.31718960
147STK380.31398368
148TESK20.30509280
149TESK10.29760428

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.37770539
2Sulfur relay system_Homo sapiens_hsa041222.61119188
3Mismatch repair_Homo sapiens_hsa034302.55190463
4DNA replication_Homo sapiens_hsa030302.41860910
5Central carbon metabolism in cancer_Homo sapiens_hsa052302.15370198
6Ribosome_Homo sapiens_hsa030101.92623711
7Chronic myeloid leukemia_Homo sapiens_hsa052201.89565326
8Lysine degradation_Homo sapiens_hsa003101.88294565
9Acute myeloid leukemia_Homo sapiens_hsa052211.86809696
10B cell receptor signaling pathway_Homo sapiens_hsa046621.79426662
11mTOR signaling pathway_Homo sapiens_hsa041501.76300453
12Pentose phosphate pathway_Homo sapiens_hsa000301.74569965
13VEGF signaling pathway_Homo sapiens_hsa043701.72530292
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72370063
15Non-small cell lung cancer_Homo sapiens_hsa052231.68995090
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57971525
17Endometrial cancer_Homo sapiens_hsa052131.51689119
18Pyrimidine metabolism_Homo sapiens_hsa002401.48164588
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46027644
20Basal cell carcinoma_Homo sapiens_hsa052171.44055693
21Renal cell carcinoma_Homo sapiens_hsa052111.43422675
22Glioma_Homo sapiens_hsa052141.43020585
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41585424
24Inositol phosphate metabolism_Homo sapiens_hsa005621.38525556
25Homologous recombination_Homo sapiens_hsa034401.37632627
26RNA polymerase_Homo sapiens_hsa030201.35934614
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35297307
28Type II diabetes mellitus_Homo sapiens_hsa049301.32161570
29Fructose and mannose metabolism_Homo sapiens_hsa000511.31441390
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31124759
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.29497283
32HIF-1 signaling pathway_Homo sapiens_hsa040661.28813660
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26270367
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25797698
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24502090
36Estrogen signaling pathway_Homo sapiens_hsa049151.21751603
37Steroid biosynthesis_Homo sapiens_hsa001001.18824943
38Small cell lung cancer_Homo sapiens_hsa052221.17308668
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16365499
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.15336654
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13919435
42T cell receptor signaling pathway_Homo sapiens_hsa046601.12778541
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12595389
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12276356
45Galactose metabolism_Homo sapiens_hsa000521.11877717
46mRNA surveillance pathway_Homo sapiens_hsa030151.09739932
47Colorectal cancer_Homo sapiens_hsa052101.09439027
48ECM-receptor interaction_Homo sapiens_hsa045121.08551781
49MicroRNAs in cancer_Homo sapiens_hsa052061.08319597
50Thyroid cancer_Homo sapiens_hsa052161.07315320
51Biosynthesis of amino acids_Homo sapiens_hsa012301.05798691
52Bladder cancer_Homo sapiens_hsa052191.04919665
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04840487
54AMPK signaling pathway_Homo sapiens_hsa041521.04017386
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.01738629
56Non-homologous end-joining_Homo sapiens_hsa034501.01699336
57Prion diseases_Homo sapiens_hsa050201.00860389
58Adherens junction_Homo sapiens_hsa045201.00486457
59Fanconi anemia pathway_Homo sapiens_hsa034601.00368885
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99684258
61Vitamin B6 metabolism_Homo sapiens_hsa007500.98853525
62Insulin resistance_Homo sapiens_hsa049310.98018742
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97115192
64Hedgehog signaling pathway_Homo sapiens_hsa043400.96898912
65N-Glycan biosynthesis_Homo sapiens_hsa005100.95912302
66Focal adhesion_Homo sapiens_hsa045100.95894252
67Spliceosome_Homo sapiens_hsa030400.94418519
68Prolactin signaling pathway_Homo sapiens_hsa049170.94172455
69Base excision repair_Homo sapiens_hsa034100.93720083
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93294776
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92411686
72RNA transport_Homo sapiens_hsa030130.90802391
73Choline metabolism in cancer_Homo sapiens_hsa052310.90213646
74Insulin signaling pathway_Homo sapiens_hsa049100.89087692
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84304200
76Selenocompound metabolism_Homo sapiens_hsa004500.84195049
77One carbon pool by folate_Homo sapiens_hsa006700.84042986
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.83951720
79HTLV-I infection_Homo sapiens_hsa051660.83757980
80Wnt signaling pathway_Homo sapiens_hsa043100.83014305
81Melanoma_Homo sapiens_hsa052180.80917289
82p53 signaling pathway_Homo sapiens_hsa041150.79591960
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78413802
84Pancreatic cancer_Homo sapiens_hsa052120.77347742
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77258183
86Antigen processing and presentation_Homo sapiens_hsa046120.76727158
87Pyruvate metabolism_Homo sapiens_hsa006200.75828341
88Viral carcinogenesis_Homo sapiens_hsa052030.75603998
89* Nucleotide excision repair_Homo sapiens_hsa034200.74459794
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73303505
91Tight junction_Homo sapiens_hsa045300.72965093
92Proteoglycans in cancer_Homo sapiens_hsa052050.72894876
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72719001
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71596357
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71322733
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70963473
97Arginine biosynthesis_Homo sapiens_hsa002200.70563161
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70464487
99Prostate cancer_Homo sapiens_hsa052150.70273209
100Folate biosynthesis_Homo sapiens_hsa007900.70190217
101ErbB signaling pathway_Homo sapiens_hsa040120.70035459
102Axon guidance_Homo sapiens_hsa043600.66498493
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66026789
104Nitrogen metabolism_Homo sapiens_hsa009100.65630735
105Oxytocin signaling pathway_Homo sapiens_hsa049210.65034026
106Purine metabolism_Homo sapiens_hsa002300.64624193
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64152295
108Shigellosis_Homo sapiens_hsa051310.63252682
109Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.62376266
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.61141894
111Glucagon signaling pathway_Homo sapiens_hsa049220.60968846
112Primary immunodeficiency_Homo sapiens_hsa053400.60405803
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60045683
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59982345
115Notch signaling pathway_Homo sapiens_hsa043300.59554236
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59212154
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.59115605
118Melanogenesis_Homo sapiens_hsa049160.58277294
119FoxO signaling pathway_Homo sapiens_hsa040680.58272054
120Platelet activation_Homo sapiens_hsa046110.57415503
121Other glycan degradation_Homo sapiens_hsa005110.56941242
122Osteoclast differentiation_Homo sapiens_hsa043800.56788676
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56690619
124Hepatitis B_Homo sapiens_hsa051610.55881941
125Epstein-Barr virus infection_Homo sapiens_hsa051690.55466888
126Carbon metabolism_Homo sapiens_hsa012000.54824560
127Proteasome_Homo sapiens_hsa030500.54592714
128Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53541833
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53208784
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52817891
131Rap1 signaling pathway_Homo sapiens_hsa040150.52207146
132Hippo signaling pathway_Homo sapiens_hsa043900.52030248
133Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51490638
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50964445
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.50885119
136Viral myocarditis_Homo sapiens_hsa054160.50475870
137Oocyte meiosis_Homo sapiens_hsa041140.50430363
138Cell cycle_Homo sapiens_hsa041100.49978489
139Pathways in cancer_Homo sapiens_hsa052000.48766380
140Apoptosis_Homo sapiens_hsa042100.48280036
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.47430093
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46523004
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45765760

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