ERCC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.24730435
2hemidesmosome assembly (GO:0031581)5.07391656
3histone H3-K36 demethylation (GO:0070544)4.78667808
4desmosome organization (GO:0002934)4.51869168
5histone H3-K4 trimethylation (GO:0080182)4.48033004
6nuclear pore organization (GO:0006999)4.36592750
7pericardium development (GO:0060039)4.34583410
8positive regulation of gamma-delta T cell activation (GO:0046645)4.34082661
9mitotic sister chromatid cohesion (GO:0007064)4.24851495
10plasma membrane repair (GO:0001778)4.16434710
11monoubiquitinated protein deubiquitination (GO:0035520)4.05600568
12cytoplasmic mRNA processing body assembly (GO:0033962)4.04078942
13regulation of DNA endoreduplication (GO:0032875)4.01005363
14pore complex assembly (GO:0046931)3.97081889
15peptidyl-lysine trimethylation (GO:0018023)3.78291659
16histone H3-K4 methylation (GO:0051568)3.76508699
17pre-miRNA processing (GO:0031054)3.75192107
18positive thymic T cell selection (GO:0045059)3.69017303
19negative regulation of cell killing (GO:0031342)3.63787151
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63787151
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.61316463
22regulation of RNA export from nucleus (GO:0046831)3.60992066
23histone H3-K9 methylation (GO:0051567)3.55670895
24cell adhesion mediated by integrin (GO:0033627)3.49001819
25regulation of transforming growth factor beta2 production (GO:0032909)3.48159194
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.47617738
27regulation of translation, ncRNA-mediated (GO:0045974)3.47617738
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.47617738
29sequestering of extracellular ligand from receptor (GO:0035581)3.47102182
30interkinetic nuclear migration (GO:0022027)3.46993467
31histone H3-K9 modification (GO:0061647)3.45833311
32positive T cell selection (GO:0043368)3.42016264
33histone H3-K9 demethylation (GO:0033169)3.36669771
34negative thymic T cell selection (GO:0045060)3.36381831
35histone lysine demethylation (GO:0070076)3.33710862
36collagen fibril organization (GO:0030199)3.33410929
37regulation of nucleobase-containing compound transport (GO:0032239)3.31246378
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29855275
39negative T cell selection (GO:0043383)3.27628217
40regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.25583870
41negative regulation of DNA repair (GO:0045738)3.22482828
42COPII vesicle coating (GO:0048208)3.22372982
43regulation of interleukin-12 biosynthetic process (GO:0045075)3.21852350
44histone lysine methylation (GO:0034968)3.21496774
45membrane raft organization (GO:0031579)3.18242379
46peptidyl-lysine methylation (GO:0018022)3.17492885
47negative regulation of histone methylation (GO:0031061)3.16218171
48regulation of gamma-delta T cell activation (GO:0046643)3.16206859
49cell-substrate junction assembly (GO:0007044)3.13925721
50histone demethylation (GO:0016577)3.12744805
51regulation of gamma-delta T cell differentiation (GO:0045586)3.10537123
52smooth muscle tissue development (GO:0048745)3.09564638
53platelet-derived growth factor receptor signaling pathway (GO:0048008)3.09366610
54establishment of protein localization to Golgi (GO:0072600)3.09270099
55lipid translocation (GO:0034204)3.08856584
56phospholipid translocation (GO:0045332)3.08856584
57thymic T cell selection (GO:0045061)3.06375442
58skin morphogenesis (GO:0043589)3.05805009
59histone H2A monoubiquitination (GO:0035518)3.04353323
60protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.04337209
61NLS-bearing protein import into nucleus (GO:0006607)3.02337543
62histone mRNA catabolic process (GO:0071044)3.02031588
63UDP-N-acetylglucosamine metabolic process (GO:0006047)3.01132924
64regulation of histone H3-K9 methylation (GO:0051570)2.97093793
65T cell selection (GO:0045058)2.97024010
66retrograde transport, vesicle recycling within Golgi (GO:0000301)2.95774646
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.95288603
68regulation of establishment of cell polarity (GO:2000114)2.89056339
69protein K48-linked deubiquitination (GO:0071108)2.88809791
70regulation of B cell receptor signaling pathway (GO:0050855)2.88107714
71regulation of transforming growth factor beta1 production (GO:0032908)2.84344567
72hypotonic response (GO:0006971)2.83083001
73fibroblast migration (GO:0010761)2.80656127
74sister chromatid cohesion (GO:0007062)2.79066217
75modulation by symbiont of host cellular process (GO:0044068)2.77276475
76protein targeting to Golgi (GO:0000042)2.76023933
77protein dealkylation (GO:0008214)2.73855191
78protein demethylation (GO:0006482)2.73855191
79regulation of hippo signaling (GO:0035330)2.71547804
80positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.70218180
81iron ion import (GO:0097286)2.69221728
82cellular response to ethanol (GO:0071361)2.69067738
83negative regulation of keratinocyte proliferation (GO:0010839)2.68555080
84positive regulation of cellular amide metabolic process (GO:0034250)2.66776006
85early endosome to late endosome transport (GO:0045022)2.66436033
86definitive hemopoiesis (GO:0060216)2.65942294
87histone methylation (GO:0016571)2.63547745
88phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63545893
89endocardial cushion development (GO:0003197)2.61843400
90interleukin-6-mediated signaling pathway (GO:0070102)2.59864726
91face morphogenesis (GO:0060325)2.58518299
92regulation of fibroblast migration (GO:0010762)2.57146365
93pathway-restricted SMAD protein phosphorylation (GO:0060389)2.55630692
94glomerular visceral epithelial cell development (GO:0072015)2.55588109
95negative regulation of neurotransmitter secretion (GO:0046929)2.54909331
96corticosteroid receptor signaling pathway (GO:0031958)2.53378040
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52384914
98positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.52142874
99peptidyl-lysine dimethylation (GO:0018027)2.51913512
100positive regulation of protein autophosphorylation (GO:0031954)2.50735685
101chondrocyte development (GO:0002063)2.49939664
102dosage compensation (GO:0007549)2.49562734
103regulation of protein polyubiquitination (GO:1902914)2.49302920
104face development (GO:0060324)2.48345593
105mRNA splice site selection (GO:0006376)2.47542295
106protein K11-linked deubiquitination (GO:0035871)2.47251716
107wound healing, spreading of epidermal cells (GO:0035313)2.45239096
108nucleus localization (GO:0051647)2.45223423
109histone H4-K16 acetylation (GO:0043984)2.44553405
110regulation of establishment or maintenance of cell polarity (GO:0032878)2.44429363
111substrate-dependent cell migration (GO:0006929)2.43113343
112keratinocyte development (GO:0003334)2.42971274
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42758167
114B cell homeostasis (GO:0001782)2.42471438
115snRNA transcription (GO:0009301)2.42357030
116peptide cross-linking (GO:0018149)2.41500367
117SMAD protein complex assembly (GO:0007183)2.40617711
118regulation of steroid hormone biosynthetic process (GO:0090030)2.40539908
119negative regulation of protein localization to cell surface (GO:2000009)2.40146817
120regulation of mitotic spindle organization (GO:0060236)2.39753693
121regulation of B cell differentiation (GO:0045577)2.39458200
122regulation of histone H3-K27 methylation (GO:0061085)2.39164951
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.38867460
124lymphangiogenesis (GO:0001946)2.38210858
125endodermal cell differentiation (GO:0035987)2.38061409
126negative regulation of complement activation (GO:0045916)2.38054762
127cellular response to interferon-alpha (GO:0035457)2.37990728
128positive regulation of B cell differentiation (GO:0045579)2.37226098
129response to interleukin-15 (GO:0070672)2.36779143
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.36618581
131cellular response to interleukin-15 (GO:0071350)2.35403301
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.34799549
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.34799549
134modulation by symbiont of host immune response (GO:0052553)2.34799549
135positive regulation by symbiont of host defense response (GO:0052509)2.34799549
136modulation by symbiont of host defense response (GO:0052031)2.34799549
137modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.34799549
138B cell receptor signaling pathway (GO:0050853)2.34753074
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.34733654
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.34733654
141positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.34733654
142regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34675647
143retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34568583
144histone H4-K8 acetylation (GO:0043982)2.33574613
145histone H4-K5 acetylation (GO:0043981)2.33574613
146keratinocyte differentiation (GO:0030216)2.33086272
147oocyte development (GO:0048599)2.32541120
148negative regulation of axon extension involved in axon guidance (GO:0048843)2.31678009
149anterior/posterior axis specification, embryo (GO:0008595)2.31276968
150positive regulation of fibroblast migration (GO:0010763)2.31084744
151interferon-gamma production (GO:0032609)2.31082694
152sister chromatid segregation (GO:0000819)2.30901339
153positive regulation of DNA-templated transcription, initiation (GO:2000144)2.30194828
154glomerular basement membrane development (GO:0032836)2.29917325
155RNA stabilization (GO:0043489)2.29781167
156mRNA stabilization (GO:0048255)2.29781167
157negative regulation of hormone biosynthetic process (GO:0032353)2.28715772
158modulation by virus of host process (GO:0019054)2.28533410
159genitalia morphogenesis (GO:0035112)2.28500594
160DNA synthesis involved in DNA repair (GO:0000731)2.28200577
161regulation of interferon-beta biosynthetic process (GO:0045357)2.27983603
162piRNA metabolic process (GO:0034587)2.27979152
163B cell proliferation (GO:0042100)2.27399262
164negative regulation of histone modification (GO:0031057)2.27328712
165blood vessel maturation (GO:0001955)2.27167858
166regulation of spindle organization (GO:0090224)2.27088229
167negative regulation of stem cell proliferation (GO:2000647)2.27034914
168regulation of histone methylation (GO:0031060)2.27033260
169insulin-like growth factor receptor signaling pathway (GO:0048009)2.26004459
170import into cell (GO:0098657)2.25674766
171negative regulation of chondrocyte differentiation (GO:0032331)2.25129728
172I-kappaB phosphorylation (GO:0007252)2.24881194
173regulation of NFAT protein import into nucleus (GO:0051532)2.24555743
174NIK/NF-kappaB signaling (GO:0038061)2.24301386
175tyrosine phosphorylation of STAT protein (GO:0007260)2.23780140
176replicative senescence (GO:0090399)2.23108640
177negative regulation of chromatin modification (GO:1903309)2.22620247
178regulation of hormone biosynthetic process (GO:0046885)2.21752596
179extracellular fibril organization (GO:0043206)2.21717529
180regulation of pigment cell differentiation (GO:0050932)2.21689345
181JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.21458180
182mesenchymal-epithelial cell signaling (GO:0060638)2.20692078
183establishment of protein localization to vacuole (GO:0072666)2.20667901

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.69046771
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.36848786
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.02449913
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67289048
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.56992824
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.38834211
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.33665453
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.15849044
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.82732135
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.72228952
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67410216
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64673165
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.54716166
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.45477908
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45471721
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.36873361
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35766926
18MYC_22102868_ChIP-Seq_BL_Human2.31023440
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.25896469
20* AHR_22903824_ChIP-Seq_MCF-7_Human2.23000728
21* CJUN_26792858_Chip-Seq_BT549_Human2.22002862
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17620032
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09838965
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09315012
25SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.08183776
26SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.08183776
27* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03027887
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.92956763
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.92401275
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91086648
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89490197
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88358214
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.86797733
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85439675
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85439675
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83053225
37* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80965191
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.79946760
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79454035
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.79172000
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78903904
42* ARNT_22903824_ChIP-Seq_MCF-7_Human1.75711975
43PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74606525
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.74516446
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74247572
46FOXM1_26456572_ChIP-Seq_MCF-7_Human1.73880331
47RUNX_20019798_ChIP-Seq_JUKART_Human1.71426230
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68979296
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.68944958
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68613123
51TP53_16413492_ChIP-PET_HCT116_Human1.68467859
52* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68380036
53ESR1_20079471_ChIP-ChIP_T-47D_Human1.65261280
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64941698
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.64502125
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.64250826
57TP53_18474530_ChIP-ChIP_U2OS_Human1.63725095
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.61444935
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61307099
60MYB_26560356_Chip-Seq_TH1_Human1.59434909
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.58397909
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57514614
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55165346
64TCF7_22412390_ChIP-Seq_EML_Mouse1.52640860
65TP63_23658742_ChIP-Seq_EP156T_Human1.49784855
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.49744757
67TAF15_26573619_Chip-Seq_HEK293_Human1.48517008
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46071161
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45135528
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.43293924
71MYB_26560356_Chip-Seq_TH2_Human1.42602815
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40331892
73PU_27001747_Chip-Seq_BMDM_Mouse1.40165897
74SCL_19346495_ChIP-Seq_HPC-7_Human1.37710110
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34355310
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33491568
77GATA1_22025678_ChIP-Seq_K562_Human1.32991525
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.31630813
79FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31006802
80CIITA_25753668_ChIP-Seq_RAJI_Human1.26443992
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25351341
82* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23720298
83BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23698406
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23621849
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20334516
86UTX_26944678_Chip-Seq_JUKART_Human1.18580425
87MAF_26560356_Chip-Seq_TH1_Human1.18567472
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18344722
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.17600337
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13053351
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11163619
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10124030
93* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09240985
94KDM2B_26808549_Chip-Seq_DND41_Human1.08804385
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08458713
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08458713
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08030475
98TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07737233
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07327496
100CDX2_22108803_ChIP-Seq_LS180_Human1.06692927
101FUS_26573619_Chip-Seq_HEK293_Human1.06684697
102RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06560219
103GBX2_23144817_ChIP-Seq_PC3_Human1.06464215
104* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05145981
105P300_19829295_ChIP-Seq_ESCs_Human1.05090558
106SPI1_23127762_ChIP-Seq_K562_Human1.04399859
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03947784
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03822442
109VDR_21846776_ChIP-Seq_THP-1_Human1.03751690
110RXR_22108803_ChIP-Seq_LS180_Human1.03676531
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03280339
112GATA3_27048872_Chip-Seq_THYMUS_Human1.02536387
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02461038
114* STAT3_23295773_ChIP-Seq_U87_Human1.01665937
115EWS_26573619_Chip-Seq_HEK293_Human1.01517650
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.00117077
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99976182
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99424590
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99342550
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98631725
121CBP_20019798_ChIP-Seq_JUKART_Human0.98631725
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97980030
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95665697
124ER_23166858_ChIP-Seq_MCF-7_Human0.95037501
125* TCF4_23295773_ChIP-Seq_U87_Human0.94906000
126RUNX1_22412390_ChIP-Seq_EML_Mouse0.94834573
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94195493
128VDR_24787735_ChIP-Seq_THP-1_Human0.92448353
129PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92416463
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91840738
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90788814
132* KDM2B_26808549_Chip-Seq_JURKAT_Human0.90566423
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90061487
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90020638
135FLI1_27457419_Chip-Seq_LIVER_Mouse0.90009233
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.89808062
137PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88764471
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85921959
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85642378
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84268891
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.83916147
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.82138866
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.82018671
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81988129
145AR_21572438_ChIP-Seq_LNCaP_Human0.81394689
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80966995
147BRD4_25478319_ChIP-Seq_HGPS_Human0.80499067
148TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79479662
149E2F1_18555785_Chip-Seq_ESCs_Mouse0.78007923
150SMAD4_21799915_ChIP-Seq_A2780_Human0.78002940
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77598334
152ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76478114
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.75814489
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75195439
155VDR_24763502_ChIP-Seq_THP-1_Human0.73772443
156DROSHA_22980978_ChIP-Seq_HELA_Human0.73501584
157SPI1_23547873_ChIP-Seq_NB4_Human0.73296573
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73066102

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.77041520
2MP0008438_abnormal_cutaneous_collagen5.75893784
3MP0005275_abnormal_skin_tensile4.90067038
4MP0003950_abnormal_plasma_membrane3.95014671
5MP0003705_abnormal_hypodermis_morpholog3.21675171
6MP0008057_abnormal_DNA_replication2.83380496
7MP0003787_abnormal_imprinting2.79950196
8MP0005076_abnormal_cell_differentiation2.59519643
9MP0001835_abnormal_antigen_presentation2.52658047
10MP0002166_altered_tumor_susceptibility2.47131373
11MP0002396_abnormal_hematopoietic_system2.43583814
12MP0008877_abnormal_DNA_methylation2.43362314
13MP0003303_peritoneal_inflammation2.38329204
14MP0005503_abnormal_tendon_morphology2.37609932
15MP0001958_emphysema2.35164627
16MP0004272_abnormal_basement_membrane2.27787982
17MP0010307_abnormal_tumor_latency2.27499838
18MP0002060_abnormal_skin_morphology2.26704621
19MP0003763_abnormal_thymus_physiology2.25540816
20MP0002006_tumorigenesis2.21613416
21MP0004808_abnormal_hematopoietic_stem2.16514322
22MP0005671_abnormal_response_to2.16043908
23MP0010094_abnormal_chromosome_stability2.15531670
24MP0003111_abnormal_nucleus_morphology2.13144298
25MP0001800_abnormal_humoral_immune2.12113555
26MP0003300_gastrointestinal_ulcer2.10519150
27MP0010352_gastrointestinal_tract_polyps2.03991989
28MP0009780_abnormal_chondrocyte_physiolo2.01722070
29MP0010368_abnormal_lymphatic_system1.95153217
30MP0005023_abnormal_wound_healing1.94103919
31MP0006054_spinal_hemorrhage1.89384783
32MP0003279_aneurysm1.88684588
33MP0004233_abnormal_muscle_weight1.84924401
34MP0005409_darkened_coat_color1.83439116
35MP0002452_abnormal_antigen_presenting1.79205507
36MP0003077_abnormal_cell_cycle1.77095288
37MP0002398_abnormal_bone_marrow1.75444437
38MP0000685_abnormal_immune_system1.74797452
39MP0005387_immune_system_phenotype1.74628940
40MP0001790_abnormal_immune_system1.74628940
41MP0005623_abnormal_meninges_morphology1.74243438
42MP0004510_myositis1.72980394
43MP0002723_abnormal_immune_serum1.66799601
44MP0001873_stomach_inflammation1.62477772
45MP0002420_abnormal_adaptive_immunity1.61787392
46MP0000703_abnormal_thymus_morphology1.61621132
47MP0001819_abnormal_immune_cell1.59907175
48MP0002168_other_aberrant_phenotype1.55760053
49MP0000015_abnormal_ear_pigmentation1.55233354
50MP0005000_abnormal_immune_tolerance1.52954205
51MP0004134_abnormal_chest_morphology1.51719231
52MP0003436_decreased_susceptibility_to1.48507182
53MP0005174_abnormal_tail_pigmentation1.47678793
54MP0004947_skin_inflammation1.46326996
55MP0003183_abnormal_peptide_metabolism1.39598190
56MP0000716_abnormal_immune_system1.39489764
57MP0008007_abnormal_cellular_replicative1.39362811
58MP0002419_abnormal_innate_immunity1.39177942
59MP0000733_abnormal_muscle_development1.38710002
60MP0002928_abnormal_bile_duct1.37386937
61MP0000689_abnormal_spleen_morphology1.32169996
62MP0003121_genomic_imprinting1.31460575
63MP0002332_abnormal_exercise_endurance1.31134527
64MP0009278_abnormal_bone_marrow1.29844629
65MP0010386_abnormal_urinary_bladder1.29654715
66MP0000767_abnormal_smooth_muscle1.29222331
67* MP0008058_abnormal_DNA_repair1.28487755
68MP0002722_abnormal_immune_system1.27337405
69MP0003828_pulmonary_edema1.26576652
70MP0002896_abnormal_bone_mineralization1.26145735
71MP0006292_abnormal_olfactory_placode1.25224746
72MP0002405_respiratory_system_inflammati1.24937207
73MP0001851_eye_inflammation1.24791258
74MP0001545_abnormal_hematopoietic_system1.24569407
75MP0005397_hematopoietic_system_phenotyp1.24569407
76MP0005083_abnormal_biliary_tract1.24242000
77MP0003045_fibrosis1.23801345
78MP0003172_abnormal_lysosome_physiology1.21132875
79MP0008961_abnormal_basal_metabolism1.20832844
80MP0003890_abnormal_embryonic-extraembry1.20613585
81MP0009384_cardiac_valve_regurgitation1.20044152
82MP0005310_abnormal_salivary_gland1.20015869
83MP0005395_other_phenotype1.19753946
84MP0003693_abnormal_embryo_hatching1.19234611
85MP0001216_abnormal_epidermal_layer1.15767028
86MP0001853_heart_inflammation1.15493391
87MP0003453_abnormal_keratinocyte_physiol1.15464239
88MP0002108_abnormal_muscle_morphology1.14410690
89MP0000013_abnormal_adipose_tissue1.13304291
90MP0000350_abnormal_cell_proliferation1.12898868
91MP0002796_impaired_skin_barrier1.11433246
92MP0002009_preneoplasia1.11048221
93MP0003091_abnormal_cell_migration1.10554738
94MP0004084_abnormal_cardiac_muscle1.09595303
95MP0005025_abnormal_response_to1.08335130
96MP0009703_decreased_birth_body1.07964065
97MP0003191_abnormal_cellular_cholesterol1.07534951
98MP0002429_abnormal_blood_cell1.07515866
99MP0003868_abnormal_feces_composition1.06536604
100MP0003656_abnormal_erythrocyte_physiolo1.04604945
101MP0001243_abnormal_dermal_layer1.02870827
102MP0001299_abnormal_eye_distance/1.00144771
103MP0000762_abnormal_tongue_morphology1.00121757
104MP0005451_abnormal_body_composition0.98987773
105MP0004197_abnormal_fetal_growth/weight/0.98454221
106MP0001879_abnormal_lymphatic_vessel0.95259495
107MP0010234_abnormal_vibrissa_follicle0.94060741
108MP0005464_abnormal_platelet_physiology0.93577918
109MP0002877_abnormal_melanocyte_morpholog0.92393402
110MP0004264_abnormal_extraembryonic_tissu0.92026327
111MP0009672_abnormal_birth_weight0.91761642
112MP0004036_abnormal_muscle_relaxation0.90540625
113MP0001348_abnormal_lacrimal_gland0.87967636
114* MP0005621_abnormal_cell_physiology0.87765170
115MP0003866_abnormal_defecation0.87484274
116* MP0001191_abnormal_skin_condition0.86878487
117MP0003941_abnormal_skin_development0.86786597
118MP0000371_diluted_coat_color0.86100872
119MP0002295_abnormal_pulmonary_circulatio0.85548778
120MP0009250_abnormal_appendicular_skeleto0.84674441
121MP0010155_abnormal_intestine_physiology0.83608703
122MP0002086_abnormal_extraembryonic_tissu0.82887804
123MP0005380_embryogenesis_phenotype0.81184019
124MP0001672_abnormal_embryogenesis/_devel0.81184019
125MP0000749_muscle_degeneration0.80497094
126MP0002095_abnormal_skin_pigmentation0.80414884
127* MP0002019_abnormal_tumor_incidence0.80127092
128MP0001915_intracranial_hemorrhage0.79907750
129* MP0010771_integument_phenotype0.79663195
130MP0001845_abnormal_inflammatory_respons0.79506767
131MP0000759_abnormal_skeletal_muscle0.79044327
132MP0000465_gastrointestinal_hemorrhage0.78790245
133MP0002088_abnormal_embryonic_growth/wei0.78373480
134MP0005248_abnormal_Harderian_gland0.77356226
135MP0010678_abnormal_skin_adnexa0.77340395
136MP0005171_absent_coat_pigmentation0.77246374
137MP0003984_embryonic_growth_retardation0.77066306
138MP0003252_abnormal_bile_duct0.76317022
139MP0003935_abnormal_craniofacial_develop0.75175559
140MP0003566_abnormal_cell_adhesion0.74668768
141* MP0005501_abnormal_skin_physiology0.73988171
142MP0000427_abnormal_hair_cycle0.73513599
143MP0001784_abnormal_fluid_regulation0.72543423
144MP0000377_abnormal_hair_follicle0.72283703
145MP0002925_abnormal_cardiovascular_devel0.71561018
146MP0002084_abnormal_developmental_patter0.71337834
147MP0005257_abnormal_intraocular_pressure0.71105342
148MP0005197_abnormal_uvea_morphology0.70875833
149MP0000428_abnormal_craniofacial_morphol0.70605125
150* MP0000313_abnormal_cell_death0.70556643
151MP0001730_embryonic_growth_arrest0.69944614
152MP0002998_abnormal_bone_remodeling0.68863491
153MP0003448_altered_tumor_morphology0.68816532
154MP0004859_abnormal_synaptic_plasticity0.68408842
155MP0000432_abnormal_head_morphology0.68297335
156MP0003718_maternal_effect0.68012082
157MP0006138_congestive_heart_failure0.67592098
158MP0002128_abnormal_blood_circulation0.67479922
159* MP0005384_cellular_phenotype0.66906955
160MP0000383_abnormal_hair_follicle0.66663617
161MP0000490_abnormal_crypts_of0.66610425
162MP0000627_abnormal_mammary_gland0.66425393
163MP0002693_abnormal_pancreas_physiology0.66353695
164MP0002160_abnormal_reproductive_system0.65254552
165MP0002282_abnormal_trachea_morphology0.63396295
166MP0003755_abnormal_palate_morphology0.62742915
167MP0001175_abnormal_lung_morphology0.62319538

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.56413148
2Aortic aneurysm (HP:0004942)3.89943114
3Atrophic scars (HP:0001075)3.81445284
4Aortic dissection (HP:0002647)3.78186800
5Premature rupture of membranes (HP:0001788)3.62553420
6Protrusio acetabuli (HP:0003179)3.59235328
7Spondylolisthesis (HP:0003302)3.52974503
8Overgrowth (HP:0001548)3.38580289
9Volvulus (HP:0002580)3.22001143
10Vascular tortuosity (HP:0004948)3.15505628
11Osteolytic defects of the hand bones (HP:0009699)3.13529796
12Osteolytic defects of the phalanges of the hand (HP:0009771)3.13529796
13Arterial tortuosity (HP:0005116)3.13137062
14Chromsome breakage (HP:0040012)3.03269910
15Ectopic kidney (HP:0000086)3.02555461
16Milia (HP:0001056)3.02410855
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91939263
18Mitral valve prolapse (HP:0001634)2.91466584
19Right ventricular cardiomyopathy (HP:0011663)2.84642884
20Chronic mucocutaneous candidiasis (HP:0002728)2.77735878
21Recurrent cutaneous fungal infections (HP:0011370)2.77735878
22Absent frontal sinuses (HP:0002688)2.76694227
23Dilatation of the ascending aorta (HP:0005111)2.71677194
24Striae distensae (HP:0001065)2.71596596
25Sparse lateral eyebrow (HP:0005338)2.69868808
26Soft skin (HP:0000977)2.68342469
27T lymphocytopenia (HP:0005403)2.61264363
28Wormian bones (HP:0002645)2.59137723
29Mediastinal lymphadenopathy (HP:0100721)2.57308163
30Recurrent fungal infections (HP:0002841)2.55902302
31Urethral obstruction (HP:0000796)2.55492918
32Long eyelashes (HP:0000527)2.44594712
33Fragile skin (HP:0001030)2.40180670
34Abnormality of T cell number (HP:0011839)2.39924855
35Heterotopia (HP:0002282)2.37303530
36Cystic hygroma (HP:0000476)2.36596468
37Fair hair (HP:0002286)2.36475007
38Cervical subluxation (HP:0003308)2.35382864
39Mitral stenosis (HP:0001718)2.35243179
40Recurrent viral infections (HP:0004429)2.34975064
41Eczematoid dermatitis (HP:0000976)2.34042805
42Cardiovascular calcification (HP:0011915)2.32856508
43Thyroiditis (HP:0100646)2.28167051
44Macroorchidism (HP:0000053)2.27369963
45Prominent nose (HP:0000448)2.27016213
46Aortic regurgitation (HP:0001659)2.26111505
47Dysmetric saccades (HP:0000641)2.25283078
48Stomatitis (HP:0010280)2.24161939
49Narrow palate (HP:0000189)2.23884759
50Oligodontia (HP:0000677)2.23451082
51Abnormality of chromosome stability (HP:0003220)2.22888075
52Broad ribs (HP:0000885)2.21684914
53Obsessive-compulsive behavior (HP:0000722)2.20935335
54Acute myeloid leukemia (HP:0004808)2.20679083
55Truncal obesity (HP:0001956)2.20086411
56Cubitus valgus (HP:0002967)2.18830696
57Relative macrocephaly (HP:0004482)2.17782107
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16261143
59Recurrent abscess formation (HP:0002722)2.16152200
60Tibial bowing (HP:0002982)2.14449736
61Short 4th metacarpal (HP:0010044)2.14351399
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14351399
63Natal tooth (HP:0000695)2.14322081
64Hypoplasia of the thymus (HP:0000778)2.14195886
65Anal stenosis (HP:0002025)2.13118633
66Recurrent bacterial skin infections (HP:0005406)2.13062368
67Increased connective tissue (HP:0009025)2.11450421
68Increased number of teeth (HP:0011069)2.11310777
69Onycholysis (HP:0001806)2.09524854
70Shallow orbits (HP:0000586)2.08409562
71Prostate neoplasm (HP:0100787)2.06315820
72Subacute progressive viral hepatitis (HP:0006572)2.05812984
73Abnormality of the ischium (HP:0003174)2.04932899
74Curly hair (HP:0002212)2.04123987
75Abnormality of the labia majora (HP:0012881)2.03854729
76Thin bony cortex (HP:0002753)2.00710550
77Joint laxity (HP:0001388)1.98099538
78Papillary thyroid carcinoma (HP:0002895)1.98053146
79Submucous cleft hard palate (HP:0000176)1.97111763
80Oligodactyly (hands) (HP:0001180)1.97082139
81Periodontitis (HP:0000704)1.96087366
82Chronic diarrhea (HP:0002028)1.93436982
83Increased density of long bones (HP:0006392)1.93108296
84Coarse hair (HP:0002208)1.92141868
85Abnormality of the nasal septum (HP:0000419)1.90292772
86Facial hemangioma (HP:0000329)1.89738500
87Short chin (HP:0000331)1.89257024
88Lip pit (HP:0100267)1.88871940
89Arterial thrombosis (HP:0004420)1.88038282
90Gingivitis (HP:0000230)1.87067011
91Agnosia (HP:0010524)1.87045718
92Vertebral arch anomaly (HP:0008438)1.85664740
93Medulloblastoma (HP:0002885)1.85008386
94Abnormality of nail color (HP:0100643)1.84384435
95Limited elbow extension (HP:0001377)1.83461907
96Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82493389
97Mild short stature (HP:0003502)1.81560886
98Thick nail (HP:0001805)1.81499566
99Clubbing of toes (HP:0100760)1.79246769
100Thoracolumbar scoliosis (HP:0002944)1.79236420
101Short nail (HP:0001799)1.79042514
102Deep philtrum (HP:0002002)1.78629296
103Severe combined immunodeficiency (HP:0004430)1.78588434
104Pectus carinatum (HP:0000768)1.76446690
105Abnormality of the acetabulum (HP:0003170)1.75861819
106Disinhibition (HP:0000734)1.75712294
107Abnormality of the intervertebral disk (HP:0005108)1.73496925
108Pulmonic stenosis (HP:0001642)1.73467378
109Recurrent skin infections (HP:0001581)1.72581994
110Abnormal hand bone ossification (HP:0010660)1.71691493
111Advanced eruption of teeth (HP:0006288)1.71281821
112* Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71243821
113Mesomelia (HP:0003027)1.71241913
114Genu recurvatum (HP:0002816)1.71150645
115Febrile seizures (HP:0002373)1.71067551
116Protruding tongue (HP:0010808)1.71024109
117Genetic anticipation (HP:0003743)1.70609202
118Inappropriate behavior (HP:0000719)1.70548140
119Myelodysplasia (HP:0002863)1.70099865
120Aneurysm (HP:0002617)1.70018667
121Transitional cell carcinoma of the bladder (HP:0006740)1.69175610
122Lymphopenia (HP:0001888)1.69069272
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.68693575
124Hypoplastic scapulae (HP:0000882)1.68011353
125Aplasia/Hypoplasia of the scapulae (HP:0006713)1.68011353
126Persistence of primary teeth (HP:0006335)1.68002797
127Pulmonary infiltrates (HP:0002113)1.67704642
128Aortic valve stenosis (HP:0001650)1.67671642
129Peritonitis (HP:0002586)1.67631151
130Thick eyebrow (HP:0000574)1.67462017
131Glucose intolerance (HP:0000833)1.67454822
132Cutis marmorata (HP:0000965)1.67081265
133Abnormality of the carotid arteries (HP:0005344)1.67055657
134Myocardial infarction (HP:0001658)1.66895538
135Long clavicles (HP:0000890)1.66470220
136Impaired smooth pursuit (HP:0007772)1.66243426
137Spinal cord lesions (HP:0100561)1.65935031
138Syringomyelia (HP:0003396)1.65935031
139Hyperextensible skin (HP:0000974)1.65559621
140Flat acetabular roof (HP:0003180)1.65153275
141Impulsivity (HP:0100710)1.65016314
142Generalized hypopigmentation of hair (HP:0011358)1.64617916
143Thyroid carcinoma (HP:0002890)1.63660900
144Abnormality of the axillary hair (HP:0100134)1.63592121
145Abnormality of secondary sexual hair (HP:0009888)1.63592121
146Agammaglobulinemia (HP:0004432)1.63416634
147Leukopenia (HP:0001882)1.63209403
148Alopecia of scalp (HP:0002293)1.63041305
149Trigonocephaly (HP:0000243)1.62892967
150Ureteral obstruction (HP:0006000)1.62237617
151Ankyloglossia (HP:0010296)1.62213682
152Hypoplastic ischia (HP:0003175)1.62203063
153Fibular aplasia (HP:0002990)1.61968717
154Abnormality of the thoracic spine (HP:0100711)1.61319114
155Tapered finger (HP:0001182)1.61108820
156Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.60096960
157Global brain atrophy (HP:0002283)1.58525027
158Abnormality of the columella (HP:0009929)1.58453068
159Hypoplastic labia majora (HP:0000059)1.58400391
160Aplasia/Hypoplasia of the uvula (HP:0010293)1.58318274
161Urinary bladder sphincter dysfunction (HP:0002839)1.58029786
162Hyperkalemia (HP:0002153)1.57867635
163Oligodactyly (HP:0012165)1.57801457
164Abnormality of the proximal phalanges of the hand (HP:0009834)1.56694318
165Ureteral stenosis (HP:0000071)1.56146284
166Low anterior hairline (HP:0000294)1.56011515
167Sandal gap (HP:0001852)1.55771575
168IgA deficiency (HP:0002720)1.55404045
169Abnormal ossification of hand bones (HP:0005921)1.54866556
170Sensory axonal neuropathy (HP:0003390)1.54444477
171Neonatal short-limb short stature (HP:0008921)1.53923521
172Abnormality of the frontal sinuses (HP:0002687)1.53683007
173Abnormality of ocular smooth pursuit (HP:0000617)1.53639299
174Autoimmune thrombocytopenia (HP:0001973)1.53239237
175Abnormality of cells of the lymphoid lineage (HP:0012140)1.52742397
176Smooth philtrum (HP:0000319)1.52610187
177Abnormality of the labia minora (HP:0012880)1.50973710
178Uterine leiomyosarcoma (HP:0002891)1.50409036
179Leiomyosarcoma (HP:0100243)1.50409036
180Dislocated radial head (HP:0003083)1.49794219
181Cafe-au-lait spot (HP:0000957)1.49718621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.90983473
2CDK124.03959210
3NEK93.55455679
4RIPK43.25013511
5LATS13.21103976
6BRD42.92022379
7SIK22.85855469
8MST1R2.61106535
9MAP4K12.58549071
10JAK32.50757741
11MET2.34441300
12TRPM72.33756003
13MAP3K142.33693830
14WNK12.18995776
15TGFBR22.15956253
16FGFR32.10278335
17TXK2.09701842
18PBK1.99647299
19PIK3CG1.90606682
20ACVR1B1.85844346
21KIT1.84476001
22INSRR1.76083713
23STK31.73802380
24MST41.72295429
25NUAK11.66343026
26FGFR41.63001649
27JAK11.60613112
28PDGFRA1.59992735
29MAP3K61.59643871
30EIF2AK31.56130370
31BRSK21.55775824
32SIK31.52711329
33IRAK31.50618518
34CDC71.45695362
35BMPR1B1.45265953
36TAOK31.41614507
37PDK21.40770401
38FLT31.39452462
39CAMK1D1.37878379
40CAMK1G1.35932148
41FER1.32417751
42PKN21.30482813
43TYK21.29253285
44PTK21.28744573
45IKBKE1.27790686
46CHUK1.25404943
47MKNK21.23974779
48NTRK31.22285038
49SGK21.21574760
50MAP3K21.21122616
51NEK61.20123967
52MAP3K101.18450150
53ATR1.15296549
54ERBB31.14589245
55SIK11.14099766
56NEK21.09649947
57ICK1.07828558
58DDR21.07592157
59MARK31.07319183
60SGK31.06495263
61MYLK1.02706943
62FRK1.00899049
63HCK1.00292258
64EEF2K0.98807524
65PDGFRB0.96381920
66PTK60.96186220
67YES10.96182707
68PIM10.95833774
69CDK60.95527144
70CDK90.93679595
71IKBKB0.92993091
72CHEK10.92191623
73PAK20.89241523
74ATM0.88960431
75SRPK10.88556602
76MELK0.84796842
77RIPK10.84543018
78MARK20.84228939
79LATS20.82713273
80PRKCH0.82583637
81ALK0.82528895
82TRIB30.82510356
83CDK40.81585606
84TGFBR10.80816094
85STK390.79302518
86MTOR0.78125855
87SGK10.76386538
88LCK0.76145449
89PTK2B0.75902329
90DMPK0.75814645
91EPHA40.74624717
92ZAK0.73342280
93SCYL20.72965066
94PRKD20.70045633
95PASK0.68516194
96TAOK10.66811227
97CAMKK20.66035876
98NLK0.65320284
99JAK20.64521553
100MKNK10.63567692
101EPHA20.63530445
102MAP3K30.63367529
103MUSK0.63226350
104SYK0.62589693
105CSNK1D0.62415784
106BMPR20.62079244
107TBK10.62009029
108CDK20.60556546
109PRKCQ0.60524889
110MAPK140.59641896
111MAP3K70.59119682
112FES0.59008128
113RAF10.58680744
114PRKAA20.58639652
115ITK0.58625221
116STK380.57520619
117TSSK60.57163048
118STK240.56345571
119SGK2230.55976048
120SGK4940.55976048
121MAP3K130.55922273
122TNK20.55742786
123MAPK110.55245132
124PRKDC0.54313351
125MAPKAPK50.53414034
126DYRK1A0.52453494
127STK100.52221423
128RET0.51815286
129BTK0.51702650
130ERBB40.51653144
131PLK30.50872751
132TTN0.50684668
133MAPK100.50615602
134MAP3K40.50180137
135CSF1R0.50126211
136MAPK70.50089421
137TEC0.49406029
138CHEK20.48700290
139RPS6KB10.48000086
140CDK10.47539974
141MOS0.46973247
142MAP3K50.46782123
143TNIK0.46044792
144GSK3B0.45012121
145LYN0.44715663
146AKT10.44433419
147PDK10.44180481
148FGFR20.43977490
149AURKB0.43323223
150ZAP700.41799656
151STK38L0.41775744
152GRK70.41626855
153CDC42BPA0.41332239
154MAP2K10.39140689
155PRKAA10.37487724
156PAK30.36316215
157PIK3CA0.35960329
158MAP3K120.35611869
159MAPK10.34485456
160KSR10.30968758
161BLK0.28594720
162IRAK10.28237904
163PRKD10.27934190
164GSK3A0.27672792
165RPS6KA20.27101290

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.32097582
2Focal adhesion_Homo sapiens_hsa045102.09752623
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.91356388
4Circadian rhythm_Homo sapiens_hsa047101.81507546
5B cell receptor signaling pathway_Homo sapiens_hsa046621.81365983
6TGF-beta signaling pathway_Homo sapiens_hsa043501.71928363
7Primary immunodeficiency_Homo sapiens_hsa053401.71849432
8Lysine degradation_Homo sapiens_hsa003101.67663006
9T cell receptor signaling pathway_Homo sapiens_hsa046601.59124836
10Measles_Homo sapiens_hsa051621.52375254
11Osteoclast differentiation_Homo sapiens_hsa043801.46864149
12Amoebiasis_Homo sapiens_hsa051461.45952115
13Type II diabetes mellitus_Homo sapiens_hsa049301.44661474
14Renal cell carcinoma_Homo sapiens_hsa052111.42003312
15Thyroid cancer_Homo sapiens_hsa052161.37037969
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36825139
17Chronic myeloid leukemia_Homo sapiens_hsa052201.35438849
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32511284
19Leishmaniasis_Homo sapiens_hsa051401.32495536
20Fanconi anemia pathway_Homo sapiens_hsa034601.30483001
21mTOR signaling pathway_Homo sapiens_hsa041501.29148336
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28995230
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.28048578
24Herpes simplex infection_Homo sapiens_hsa051681.27665074
25Hepatitis B_Homo sapiens_hsa051611.24342020
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23463897
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22584205
28MicroRNAs in cancer_Homo sapiens_hsa052061.22105911
29Melanoma_Homo sapiens_hsa052181.19791447
30Influenza A_Homo sapiens_hsa051641.18942837
31Prolactin signaling pathway_Homo sapiens_hsa049171.15903355
32TNF signaling pathway_Homo sapiens_hsa046681.15817005
33Pancreatic cancer_Homo sapiens_hsa052121.14941289
34Chemokine signaling pathway_Homo sapiens_hsa040621.13595170
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10414071
36Hematopoietic cell lineage_Homo sapiens_hsa046401.09919210
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.09438538
38Hippo signaling pathway_Homo sapiens_hsa043901.07271289
39Toxoplasmosis_Homo sapiens_hsa051451.07228086
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.06980671
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06621416
42Small cell lung cancer_Homo sapiens_hsa052221.06533124
43Pathways in cancer_Homo sapiens_hsa052001.06281350
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05264471
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04813590
46Endometrial cancer_Homo sapiens_hsa052131.04702021
47Non-homologous end-joining_Homo sapiens_hsa034501.03997317
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03988249
49Non-small cell lung cancer_Homo sapiens_hsa052231.02985260
50Viral carcinogenesis_Homo sapiens_hsa052031.01961219
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99530492
52Glioma_Homo sapiens_hsa052140.98667660
53One carbon pool by folate_Homo sapiens_hsa006700.98394741
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98339262
55Acute myeloid leukemia_Homo sapiens_hsa052210.98179559
56Hedgehog signaling pathway_Homo sapiens_hsa043400.96877902
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.96293597
58HTLV-I infection_Homo sapiens_hsa051660.95398803
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95301187
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93558889
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93524528
62Prostate cancer_Homo sapiens_hsa052150.93486683
63Tuberculosis_Homo sapiens_hsa051520.92165052
64mRNA surveillance pathway_Homo sapiens_hsa030150.91280481
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90873410
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.88593116
67Apoptosis_Homo sapiens_hsa042100.88015876
68Type I diabetes mellitus_Homo sapiens_hsa049400.87005736
69Dilated cardiomyopathy_Homo sapiens_hsa054140.86992608
70Antigen processing and presentation_Homo sapiens_hsa046120.86082891
71ABC transporters_Homo sapiens_hsa020100.85052635
72Bladder cancer_Homo sapiens_hsa052190.84075090
73FoxO signaling pathway_Homo sapiens_hsa040680.83639323
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83026197
75p53 signaling pathway_Homo sapiens_hsa041150.83003299
76Inositol phosphate metabolism_Homo sapiens_hsa005620.82664065
77Sphingolipid metabolism_Homo sapiens_hsa006000.82488722
78Gap junction_Homo sapiens_hsa045400.82265368
79ErbB signaling pathway_Homo sapiens_hsa040120.81458358
80Colorectal cancer_Homo sapiens_hsa052100.80690445
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79997037
82Cell cycle_Homo sapiens_hsa041100.79900323
83Basal cell carcinoma_Homo sapiens_hsa052170.77815953
84Viral myocarditis_Homo sapiens_hsa054160.76894402
85Allograft rejection_Homo sapiens_hsa053300.76366201
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.75854307
87Ovarian steroidogenesis_Homo sapiens_hsa049130.75129625
88Rap1 signaling pathway_Homo sapiens_hsa040150.74820313
89Systemic lupus erythematosus_Homo sapiens_hsa053220.74720576
90Endocytosis_Homo sapiens_hsa041440.74301785
91Long-term depression_Homo sapiens_hsa047300.74162315
92Hepatitis C_Homo sapiens_hsa051600.74003412
93Insulin resistance_Homo sapiens_hsa049310.73438745
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72614696
95RNA degradation_Homo sapiens_hsa030180.72442816
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69978508
97MAPK signaling pathway_Homo sapiens_hsa040100.69964409
98Nicotine addiction_Homo sapiens_hsa050330.69376754
99Ras signaling pathway_Homo sapiens_hsa040140.69076213
100Long-term potentiation_Homo sapiens_hsa047200.68822493
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68573195
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68399954
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68170147
104Renin secretion_Homo sapiens_hsa049240.66750115
105GnRH signaling pathway_Homo sapiens_hsa049120.66431899
106Epstein-Barr virus infection_Homo sapiens_hsa051690.65169322
107Wnt signaling pathway_Homo sapiens_hsa043100.64680567
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64273009
109Homologous recombination_Homo sapiens_hsa034400.62655040
110Morphine addiction_Homo sapiens_hsa050320.62465900
111Estrogen signaling pathway_Homo sapiens_hsa049150.62379994
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62287083
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.61436336
114Notch signaling pathway_Homo sapiens_hsa043300.61226623
115Choline metabolism in cancer_Homo sapiens_hsa052310.60443359
116Proteoglycans in cancer_Homo sapiens_hsa052050.60061123
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.59841419
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59597883
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59570971
120Adherens junction_Homo sapiens_hsa045200.59038828
121HIF-1 signaling pathway_Homo sapiens_hsa040660.58547674
122Melanogenesis_Homo sapiens_hsa049160.58346769
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58265162
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57188167
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.57161653
126Selenocompound metabolism_Homo sapiens_hsa004500.56974661
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56825312
128RNA transport_Homo sapiens_hsa030130.56765155
129Graft-versus-host disease_Homo sapiens_hsa053320.52903375
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50857529
131Platelet activation_Homo sapiens_hsa046110.50723811
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50165639
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49551294
134Insulin secretion_Homo sapiens_hsa049110.48717262
135Cholinergic synapse_Homo sapiens_hsa047250.48577844
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48101282
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47528153
138Malaria_Homo sapiens_hsa051440.47434087
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47248080
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47014496

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