ERCC6L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.71546129
2DNA unwinding involved in DNA replication (GO:0006268)5.23317185
3mitotic metaphase plate congression (GO:0007080)5.14323376
4nuclear pore organization (GO:0006999)4.85686405
5protein localization to chromosome, centromeric region (GO:0071459)4.83223691
6mitotic sister chromatid segregation (GO:0000070)4.81943190
7nuclear pore complex assembly (GO:0051292)4.81628162
8DNA strand elongation involved in DNA replication (GO:0006271)4.79360554
9DNA replication initiation (GO:0006270)4.78337760
10mitotic chromosome condensation (GO:0007076)4.77279215
11establishment of integrated proviral latency (GO:0075713)4.75885140
12DNA replication checkpoint (GO:0000076)4.73316581
13CENP-A containing nucleosome assembly (GO:0034080)4.69835908
14chromatin remodeling at centromere (GO:0031055)4.65615939
15sister chromatid segregation (GO:0000819)4.61646043
16metaphase plate congression (GO:0051310)4.57985275
17DNA strand elongation (GO:0022616)4.56692882
18kinetochore organization (GO:0051383)4.54571145
19telomere maintenance via semi-conservative replication (GO:0032201)4.49012648
20DNA replication-dependent nucleosome assembly (GO:0006335)4.39435130
21DNA replication-dependent nucleosome organization (GO:0034723)4.39435130
22attachment of spindle microtubules to kinetochore (GO:0008608)4.35193616
23DNA replication-independent nucleosome assembly (GO:0006336)4.32240345
24DNA replication-independent nucleosome organization (GO:0034724)4.32240345
25mitotic recombination (GO:0006312)4.31267309
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.30910306
27mitotic nuclear envelope disassembly (GO:0007077)4.29876207
28meiotic chromosome segregation (GO:0045132)4.19949526
29telomere maintenance via recombination (GO:0000722)4.18548136
30regulation of spindle organization (GO:0090224)4.08722286
31establishment of chromosome localization (GO:0051303)4.07621364
32membrane disassembly (GO:0030397)3.97944029
33nuclear envelope disassembly (GO:0051081)3.97944029
34mitotic sister chromatid cohesion (GO:0007064)3.97713788
35histone exchange (GO:0043486)3.95883517
36kinetochore assembly (GO:0051382)3.92621463
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.90167695
38nucleobase biosynthetic process (GO:0046112)3.89139758
39DNA ligation (GO:0006266)3.85594769
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77225437
41telomere maintenance via telomere lengthening (GO:0010833)3.74742002
42pore complex assembly (GO:0046931)3.73529991
43positive regulation of chromosome segregation (GO:0051984)3.72863798
44protein localization to chromosome (GO:0034502)3.72815723
45spindle checkpoint (GO:0031577)3.68158873
46IMP biosynthetic process (GO:0006188)3.65974348
47regulation of mitotic spindle organization (GO:0060236)3.65457394
48regulation of chromosome segregation (GO:0051983)3.65249110
49DNA geometric change (GO:0032392)3.64175951
50DNA duplex unwinding (GO:0032508)3.64125782
51double-strand break repair via nonhomologous end joining (GO:0006303)3.63532362
52non-recombinational repair (GO:0000726)3.63532362
53chromosome segregation (GO:0007059)3.61772420
54purine nucleobase biosynthetic process (GO:0009113)3.61630972
55chromatin assembly or disassembly (GO:0006333)3.59933864
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.55942642
57spindle assembly checkpoint (GO:0071173)3.54460036
58negative regulation of chromosome segregation (GO:0051985)3.54375643
59protein K6-linked ubiquitination (GO:0085020)3.54085738
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.53467187
61establishment of viral latency (GO:0019043)3.52322581
62negative regulation of mitotic sister chromatid separation (GO:2000816)3.49878525
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49878525
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49878525
65negative regulation of sister chromatid segregation (GO:0033046)3.49878525
66regulation of double-strand break repair via homologous recombination (GO:0010569)3.49748582
67regulation of mitotic metaphase/anaphase transition (GO:0030071)3.48754360
68regulation of centrosome cycle (GO:0046605)3.48012967
69regulation of DNA endoreduplication (GO:0032875)3.46772062
70regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41403791
71mitotic spindle assembly checkpoint (GO:0007094)3.40805278
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40332959
73folic acid-containing compound biosynthetic process (GO:0009396)3.40192895
74positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40019002
75positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40019002
76positive regulation of mitotic sister chromatid separation (GO:1901970)3.40019002
77mitotic spindle checkpoint (GO:0071174)3.39618411
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.35917412
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35917412
80microtubule depolymerization (GO:0007019)3.33977638
81regulation of sister chromatid cohesion (GO:0007063)3.33689193
82regulation of mitotic sister chromatid segregation (GO:0033047)3.33129864
83regulation of sister chromatid segregation (GO:0033045)3.33129864
84regulation of mitotic sister chromatid separation (GO:0010965)3.33129864
85protein complex localization (GO:0031503)3.32073777
86ATP-dependent chromatin remodeling (GO:0043044)3.27017510
87formation of translation preinitiation complex (GO:0001731)3.22755458
88chromosome condensation (GO:0030261)3.22256165
89DNA conformation change (GO:0071103)3.22249967
90DNA double-strand break processing (GO:0000729)3.19477189
91IMP metabolic process (GO:0046040)3.19374828
92heterochromatin organization (GO:0070828)3.19217768
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18529727
94regulation of helicase activity (GO:0051095)3.18506988
95regulation of centriole replication (GO:0046599)3.17899900
96postreplication repair (GO:0006301)3.14617275
97mismatch repair (GO:0006298)3.12827280
98telomere maintenance (GO:0000723)3.11570580
99DNA synthesis involved in DNA repair (GO:0000731)3.11362160
100negative regulation of mitosis (GO:0045839)3.10856712
101regulation of histone H3-K9 methylation (GO:0051570)3.10190299
102regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.09776369
103regulation of mitotic spindle checkpoint (GO:1903504)3.09776369
104telomere organization (GO:0032200)3.09367079
105mitotic G2/M transition checkpoint (GO:0044818)3.07156710
106regulation of double-strand break repair (GO:2000779)3.06916181
107DNA topological change (GO:0006265)3.04974204
108nuclear envelope organization (GO:0006998)3.03706193
109* mitotic cell cycle (GO:0000278)3.03453605
110regulation of centrosome duplication (GO:0010824)3.03267632
111translesion synthesis (GO:0019985)3.02419137
112DNA packaging (GO:0006323)3.01160079
113ribosome assembly (GO:0042255)2.96358794
114dosage compensation (GO:0007549)2.94184930
115ribosome biogenesis (GO:0042254)2.93370023
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.92666563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.98852112
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.66206126
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.93204508
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.74727884
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89621199
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.72290052
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71794915
8AR_21909140_ChIP-Seq_LNCAP_Human2.69020116
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59679717
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.48145465
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.40654872
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.40276998
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36181915
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.35873068
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35670094
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27431239
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21102963
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15097133
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.09276639
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.05867595
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01842654
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01762209
23XRN2_22483619_ChIP-Seq_HELA_Human2.01622567
24E2F7_22180533_ChIP-Seq_HELA_Human11.1128023
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97578033
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88367193
27VDR_23849224_ChIP-Seq_CD4+_Human1.88060867
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86961701
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.78780734
30FOXP3_21729870_ChIP-Seq_TREG_Human1.73550462
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70768524
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70429660
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67837917
34DCP1A_22483619_ChIP-Seq_HELA_Human1.65132606
35ELK1_19687146_ChIP-ChIP_HELA_Human1.63176415
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62901738
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62788033
38TTF2_22483619_ChIP-Seq_HELA_Human1.60143431
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51694561
40GABP_19822575_ChIP-Seq_HepG2_Human1.50584979
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48405564
42MYC_22102868_ChIP-Seq_BL_Human1.48207845
43CIITA_25753668_ChIP-Seq_RAJI_Human1.46676945
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46436554
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.44821142
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43777828
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43136783
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41061982
49KDM5A_27292631_Chip-Seq_BREAST_Human1.40817442
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38896372
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38146120
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37177235
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35120088
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34970559
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34848771
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30412359
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30092380
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27804236
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25125756
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24225391
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23417127
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20892300
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.18206561
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17722486
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.17714992
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16820136
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15274714
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08975804
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07226996
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.06696877
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05813669
72SOX17_20123909_ChIP-Seq_XEN_Mouse1.05706903
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04095168
74EWS_26573619_Chip-Seq_HEK293_Human1.04047455
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02251174
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01589713
77TFEB_21752829_ChIP-Seq_HELA_Human1.00582555
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00041210
79CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99878705
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99626193
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98934632
82NANOG_21062744_ChIP-ChIP_HESCs_Human0.98822943
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94340205
84MYC_18940864_ChIP-ChIP_HL60_Human0.94057206
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93457445
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91751145
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.90911540
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90032149
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89485541
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87381058
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86000507
92NOTCH1_21737748_ChIP-Seq_TLL_Human0.85716229
93* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.85432659
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85363353
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84835462
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.82893398
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.82893398
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.82893398
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82797420
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82194859
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81374390
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80655004
103FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80458639
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79200200
105FUS_26573619_Chip-Seq_HEK293_Human0.78252163
106IRF1_19129219_ChIP-ChIP_H3396_Human0.77456804
107VDR_21846776_ChIP-Seq_THP-1_Human0.76103460
108TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75484186
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.75192044
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74748818
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74673311
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.73101544
113CHD1_26751641_Chip-Seq_LNCaP_Human0.72946092
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72366812
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71324714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.17212729
2MP0003693_abnormal_embryo_hatching5.06980223
3MP0008057_abnormal_DNA_replication4.77170848
4MP0003111_abnormal_nucleus_morphology4.72210477
5MP0003077_abnormal_cell_cycle4.16521465
6MP0004957_abnormal_blastocyst_morpholog4.08175452
7MP0008058_abnormal_DNA_repair3.39474108
8MP0003123_paternal_imprinting2.67235173
9MP0008932_abnormal_embryonic_tissue2.66023694
10MP0008007_abnormal_cellular_replicative2.64550611
11MP0008877_abnormal_DNA_methylation2.44841529
12MP0002396_abnormal_hematopoietic_system2.43190313
13MP0000350_abnormal_cell_proliferation2.36906337
14MP0010307_abnormal_tumor_latency2.35305183
15MP0001730_embryonic_growth_arrest2.29975701
16MP0010352_gastrointestinal_tract_polyps2.27714780
17MP0001672_abnormal_embryogenesis/_devel1.88847685
18MP0005380_embryogenesis_phenotype1.88847685
19MP0003786_premature_aging1.83388020
20MP0001697_abnormal_embryo_size1.80740429
21MP0003890_abnormal_embryonic-extraembry1.75030857
22MP0003121_genomic_imprinting1.73294350
23MP0005076_abnormal_cell_differentiation1.69136490
24MP0002085_abnormal_embryonic_tissue1.67264991
25MP0000490_abnormal_crypts_of1.67174610
26MP0003984_embryonic_growth_retardation1.65295253
27MP0004808_abnormal_hematopoietic_stem1.62834125
28MP0002088_abnormal_embryonic_growth/wei1.61563668
29MP0002084_abnormal_developmental_patter1.58127899
30MP0002080_prenatal_lethality1.55279229
31MP0004197_abnormal_fetal_growth/weight/1.52594559
32MP0002086_abnormal_extraembryonic_tissu1.50894920
33MP0003718_maternal_effect1.42697910
34MP0000313_abnormal_cell_death1.42148680
35MP0002019_abnormal_tumor_incidence1.38295833
36MP0002210_abnormal_sex_determination1.34644468
37MP0010030_abnormal_orbit_morphology1.28825066
38MP0003567_abnormal_fetal_cardiomyocyte1.26555686
39MP0001293_anophthalmia1.22862783
40MP0006035_abnormal_mitochondrial_morpho1.22238292
41MP0001145_abnormal_male_reproductive1.15657493
42MP0008789_abnormal_olfactory_epithelium1.14528461
43MP0003705_abnormal_hypodermis_morpholog1.14053864
44MP0003937_abnormal_limbs/digits/tail_de1.10597915
45MP0001929_abnormal_gametogenesis1.08527919
46MP0002233_abnormal_nose_morphology1.05629139
47MP0001545_abnormal_hematopoietic_system1.05383213
48MP0005397_hematopoietic_system_phenotyp1.05383213
49MP0000653_abnormal_sex_gland1.03475354
50MP0003315_abnormal_perineum_morphology1.02279240
51MP0009053_abnormal_anal_canal1.01064619
52MP0002111_abnormal_tail_morphology0.99742943
53MP0001119_abnormal_female_reproductive0.97359260
54MP0003950_abnormal_plasma_membrane0.96535306
55MP0003806_abnormal_nucleotide_metabolis0.95142151
56MP0000537_abnormal_urethra_morphology0.94663014
57MP0000703_abnormal_thymus_morphology0.93925720
58MP0004233_abnormal_muscle_weight0.92780187
59MP0009333_abnormal_splenocyte_physiolog0.90492675
60MP0005395_other_phenotype0.90217729
61MP0006292_abnormal_olfactory_placode0.90098487
62MP0003941_abnormal_skin_development0.89076557
63MP0009703_decreased_birth_body0.87090899
64MP0005499_abnormal_olfactory_system0.86809578
65MP0005394_taste/olfaction_phenotype0.86809578
66MP0002938_white_spotting0.86236454
67MP0005023_abnormal_wound_healing0.86190994
68MP0002398_abnormal_bone_marrow0.85439361
69MP0001529_abnormal_vocalization0.84631002
70MP0005621_abnormal_cell_physiology0.83974036
71MP0006054_spinal_hemorrhage0.83207039
72MP0003119_abnormal_digestive_system0.83114470
73MP0005384_cellular_phenotype0.82946761
74MP0009672_abnormal_birth_weight0.82445511
75MP0003861_abnormal_nervous_system0.80595627
76MP0002102_abnormal_ear_morphology0.80568528
77MP0002722_abnormal_immune_system0.79957186
78MP0003787_abnormal_imprinting0.79472168
79MP0002160_abnormal_reproductive_system0.78687641
80MP0000689_abnormal_spleen_morphology0.76160338
81MP0001286_abnormal_eye_development0.75612455
82MP0006036_abnormal_mitochondrial_physio0.73280234
83MP0002092_abnormal_eye_morphology0.72843531
84MP0002653_abnormal_ependyma_morphology0.71846257
85MP0002234_abnormal_pharynx_morphology0.71819190
86MP0000858_altered_metastatic_potential0.71391796
87MP0005389_reproductive_system_phenotype0.71168008
88MP0001346_abnormal_lacrimal_gland0.70926800
89MP0005501_abnormal_skin_physiology0.70528696
90MP0003221_abnormal_cardiomyocyte_apopto0.68985439
91MP0000428_abnormal_craniofacial_morphol0.68552824
92MP0001915_intracranial_hemorrhage0.68345275
93MP0000432_abnormal_head_morphology0.68302547
94MP0004264_abnormal_extraembryonic_tissu0.67869683
95MP0009278_abnormal_bone_marrow0.67425846
96MP0003566_abnormal_cell_adhesion0.67362757
97MP0000647_abnormal_sebaceous_gland0.67070877
98MP0002161_abnormal_fertility/fecundity0.66886375
99MP0003943_abnormal_hepatobiliary_system0.66752861
100MP0003186_abnormal_redox_activity0.66494902
101MP0002796_impaired_skin_barrier0.65367435
102MP0004133_heterotaxia0.65086877
103MP0004185_abnormal_adipocyte_glucose0.64363883
104MP0003763_abnormal_thymus_physiology0.63747121
105MP0003935_abnormal_craniofacial_develop0.63619760
106MP0000762_abnormal_tongue_morphology0.63445658
107MP0001661_extended_life_span0.63338386
108MP0003698_abnormal_male_reproductive0.63212685
109MP0002429_abnormal_blood_cell0.62625000
110MP0009697_abnormal_copulation0.62326679
111MP0003699_abnormal_female_reproductive0.61990632
112MP0003115_abnormal_respiratory_system0.61904076
113MP0006072_abnormal_retinal_apoptosis0.60888654
114MP0002075_abnormal_coat/hair_pigmentati0.60471128
115MP0002925_abnormal_cardiovascular_devel0.60348817
116MP0002877_abnormal_melanocyte_morpholog0.60062924
117MP0002697_abnormal_eye_size0.59915264
118MP0001727_abnormal_embryo_implantation0.59847853
119MP0003755_abnormal_palate_morphology0.59824765
120MP0002132_abnormal_respiratory_system0.58596028
121MP0000358_abnormal_cell_content/0.58396426
122MP0003136_yellow_coat_color0.58256004
123MP0000477_abnormal_intestine_morphology0.58180975
124MP0010234_abnormal_vibrissa_follicle0.56812972
125MP0002163_abnormal_gland_morphology0.56511620
126MP0003448_altered_tumor_morphology0.56297186
127MP0005391_vision/eye_phenotype0.56174927
128MP0001188_hyperpigmentation0.54522184
129MP0000733_abnormal_muscle_development0.54244462
130MP0002095_abnormal_skin_pigmentation0.54230144
131MP0002114_abnormal_axial_skeleton0.53873729
132MP0000627_abnormal_mammary_gland0.53688357
133MP0001849_ear_inflammation0.53333686
134MP0003936_abnormal_reproductive_system0.53138913
135MP0001186_pigmentation_phenotype0.52332675

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.76686161
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.68093131
3Abnormality of chromosome stability (HP:0003220)4.06178712
4Birth length less than 3rd percentile (HP:0003561)3.87479475
5Meckel diverticulum (HP:0002245)3.79649802
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.78427205
7Abnormality of the preputium (HP:0100587)3.64886898
8Abnormality of the ileum (HP:0001549)3.60668563
9Reticulocytopenia (HP:0001896)3.56286366
10Medulloblastoma (HP:0002885)3.53332526
11Patellar aplasia (HP:0006443)3.31180367
12Ependymoma (HP:0002888)3.30748546
13Abnormality of the labia minora (HP:0012880)3.21530484
14Ectopic kidney (HP:0000086)3.16716685
15Impulsivity (HP:0100710)3.14293329
16Duodenal stenosis (HP:0100867)3.12555353
17Small intestinal stenosis (HP:0012848)3.12555353
18Aplasia/Hypoplasia of the patella (HP:0006498)3.09504603
19Breast hypoplasia (HP:0003187)2.98652076
20Selective tooth agenesis (HP:0001592)2.97245952
21Absent radius (HP:0003974)2.90668914
22Increased nuchal translucency (HP:0010880)2.84159584
23Colon cancer (HP:0003003)2.82419756
24Myelodysplasia (HP:0002863)2.81186344
25Volvulus (HP:0002580)2.80955877
26Abnormality of the carotid arteries (HP:0005344)2.78519613
27Rhabdomyosarcoma (HP:0002859)2.77696907
28Duplicated collecting system (HP:0000081)2.74634773
29Absent forearm bone (HP:0003953)2.71247407
30Aplasia involving forearm bones (HP:0009822)2.71247407
31Agnosia (HP:0010524)2.70785915
32Cortical dysplasia (HP:0002539)2.70495668
33Abnormal lung lobation (HP:0002101)2.65679184
34Sloping forehead (HP:0000340)2.62622082
35Supernumerary spleens (HP:0009799)2.62555191
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.62545197
37Absent thumb (HP:0009777)2.61522955
38Multiple enchondromatosis (HP:0005701)2.57474013
39Nephroblastoma (Wilms tumor) (HP:0002667)2.54084828
40Abnormality of the duodenum (HP:0002246)2.52028643
41Short 4th metacarpal (HP:0010044)2.50100253
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.50100253
43Bone marrow hypocellularity (HP:0005528)2.47785133
44Deviation of the thumb (HP:0009603)2.46585725
45Abnormality of the renal collecting system (HP:0004742)2.45075445
46Degeneration of anterior horn cells (HP:0002398)2.44598023
47Abnormality of the anterior horn cell (HP:0006802)2.44598023
48Proximal placement of thumb (HP:0009623)2.44026230
49Carpal bone hypoplasia (HP:0001498)2.42337181
50Embryonal renal neoplasm (HP:0011794)2.39677197
51Clubbing of toes (HP:0100760)2.38425154
5211 pairs of ribs (HP:0000878)2.37953141
53Tracheoesophageal fistula (HP:0002575)2.37702004
54Oral leukoplakia (HP:0002745)2.34221480
55Short thumb (HP:0009778)2.32664406
56Aplastic anemia (HP:0001915)2.31444574
57Astrocytoma (HP:0009592)2.31434911
58Abnormality of the astrocytes (HP:0100707)2.31434911
59Cafe-au-lait spot (HP:0000957)2.28694993
60Facial cleft (HP:0002006)2.27785216
61Facial hemangioma (HP:0000329)2.23171344
62Abnormality of DNA repair (HP:0003254)2.21359171
63Glioma (HP:0009733)2.20532639
64Abnormal number of incisors (HP:0011064)2.20111921
65Basal cell carcinoma (HP:0002671)2.19646815
66Neoplasm of the pancreas (HP:0002894)2.17285884
67Horseshoe kidney (HP:0000085)2.13321884
68Triphalangeal thumb (HP:0001199)2.10858830
69Missing ribs (HP:0000921)2.10293029
70Embryonal neoplasm (HP:0002898)2.09631023
71Atresia of the external auditory canal (HP:0000413)2.06966019
72Prominent nose (HP:0000448)2.06003005
73Neoplasm of striated muscle (HP:0009728)2.03428294
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.98998733
75Abnormality of methionine metabolism (HP:0010901)1.95296714
76Squamous cell carcinoma (HP:0002860)1.94829547
77Abnormality of chromosome segregation (HP:0002916)1.93926847
78Rough bone trabeculation (HP:0100670)1.93435104
79Abnormality of cells of the erythroid lineage (HP:0012130)1.92019453
80Deep philtrum (HP:0002002)1.91573557
81Abnormality of pyrimidine metabolism (HP:0004353)1.91310762
82Abnormal number of erythroid precursors (HP:0012131)1.90514212
83Rib fusion (HP:0000902)1.89568722
84Microvesicular hepatic steatosis (HP:0001414)1.89017540
85High pitched voice (HP:0001620)1.86392983
86Neoplasm of the oral cavity (HP:0100649)1.84793979
87Biliary tract neoplasm (HP:0100574)1.84456564
88Premature graying of hair (HP:0002216)1.83379206
89Arteriovenous malformation (HP:0100026)1.80994489
90Microglossia (HP:0000171)1.78586727
91Renal duplication (HP:0000075)1.77908492
92Neoplasm of the colon (HP:0100273)1.77179287
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76941716
94Cutaneous melanoma (HP:0012056)1.75714846
95Aplasia/hypoplasia of the humerus (HP:0006507)1.75469385
96Sandal gap (HP:0001852)1.74917941
97Uterine neoplasm (HP:0010784)1.74904552
98Abnormality of glycolysis (HP:0004366)1.74512944
99Progressive external ophthalmoplegia (HP:0000590)1.74234927
100Abnormality of the calcaneus (HP:0008364)1.73904093
101Hypoplastic pelvis (HP:0008839)1.73473486
102Choanal atresia (HP:0000453)1.73151824
103Abnormality of the umbilical cord (HP:0010881)1.72967239
104Breast carcinoma (HP:0003002)1.72636558
105Increased serum pyruvate (HP:0003542)1.72634174
106Increased hepatocellular lipid droplets (HP:0006565)1.72507588
107Ureteral duplication (HP:0000073)1.70987224
108Spinal muscular atrophy (HP:0007269)1.70184775
109Long eyelashes (HP:0000527)1.68554087
110Abnormality of the septum pellucidum (HP:0007375)1.68512427
111Neoplasm of the adrenal cortex (HP:0100641)1.68379517
112Abnormal umbilical cord blood vessels (HP:0011403)1.68331488
113Single umbilical artery (HP:0001195)1.68331488
114Abnormality of the fetal cardiovascular system (HP:0010948)1.68331488
115Ovarian neoplasm (HP:0100615)1.65764985
116Duplication of thumb phalanx (HP:0009942)1.65604276
117Malignant gastrointestinal tract tumors (HP:0006749)1.65199399
118Gastrointestinal carcinoma (HP:0002672)1.65199399
119Amaurosis fugax (HP:0100576)1.64336429
120Blepharitis (HP:0000498)1.63785702
121Spastic diplegia (HP:0001264)1.61785468
122Lymphoma (HP:0002665)1.60711459
123Poikiloderma (HP:0001029)1.60056828
124Premature ovarian failure (HP:0008209)1.58725739
125Cleft eyelid (HP:0000625)1.57217411
126Neoplasm of the adrenal gland (HP:0100631)1.55286027
127Capillary hemangiomas (HP:0005306)1.54853778
128Leiomyosarcoma (HP:0100243)1.54577657
129Uterine leiomyosarcoma (HP:0002891)1.54577657
130High anterior hairline (HP:0009890)1.53715652
131Prominent metopic ridge (HP:0005487)1.53223315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.14062935
2WEE14.54295228
3BUB13.60724403
4NEK23.24287126
5BRSK22.87654275
6TTK2.86513721
7EIF2AK12.84244035
8NEK12.75692920
9SRPK12.59749346
10CDK122.46928969
11PLK42.38917624
12* PLK12.38475097
13VRK22.14650428
14ACVR1B2.09721798
15AURKB1.96967931
16PLK31.96666719
17BRSK11.89021515
18ATR1.88049103
19CCNB11.84466044
20TRIM281.83089693
21CDK71.82147430
22CHEK21.77448687
23MST41.76215580
24MKNK11.73167887
25TLK11.62971929
26TSSK61.62969592
27VRK11.61736956
28TAF11.60542128
29STK101.56137932
30EIF2AK31.54381882
31MAP3K81.50400926
32STK41.49817588
33CHEK11.45004266
34CDK41.42670966
35ZAK1.39194930
36EEF2K1.36352645
37MKNK21.35020253
38RPS6KB21.33647909
39PASK1.31755405
40DYRK31.21263691
41AURKA1.21089305
42TESK21.16745331
43PNCK1.16668689
44RPS6KA41.16104585
45MELK1.15344627
46BRD41.11196614
47ATM1.10564434
48STK31.09097553
49ERBB40.98824221
50NUAK10.97164475
51CDK20.96130916
52CLK10.95479086
53SMG10.94725270
54CDK60.93785542
55LATS10.89783383
56NME20.88280182
57PIM10.87991540
58EIF2AK20.83313480
59* CDK10.81964591
60EPHA20.81432615
61MAP3K100.80328152
62TGFBR10.80223276
63MST1R0.77359346
64SCYL20.77068907
65TNIK0.76285082
66PAK40.72668511
67CDK80.71816710
68YES10.71233331
69WNK30.70150058
70ALK0.69991665
71STK38L0.68179686
72MET0.65737185
73NME10.64446312
74NEK90.54022748
75LATS20.53723273
76CSNK2A10.53487128
77BRAF0.53220727
78CSNK2A20.52547150
79BCR0.52397714
80PLK20.50330056
81TAOK20.48658412
82BMPR1B0.46117748
83MAP2K30.45447410
84PAK10.45267656
85AKT30.42450410
86STK160.41636238
87MTOR0.41403184
88PBK0.40490843
89MAP3K90.37525687
90PRKCI0.36794051
91CDK90.36671640
92PRKDC0.35969672
93FLT30.35031862
94RPS6KA50.35006991
95PKN20.34880982
96NEK60.33614953
97CSNK1G30.33349002
98AKT20.33229419
99TESK10.32948113
100STK240.32494238
101MAPK140.32464754
102CSNK1D0.31808249
103LRRK20.31321698
104CDK180.31182549
105CSF1R0.30699318
106PDK20.30657772
107CAMK1G0.27892397
108CDK150.27264321
109CSNK1A1L0.26924932
110CSNK1E0.26085669
111CDK11A0.25615390
112AKT10.25604294
113TRPM70.25252550
114ERBB30.24916456
115CSNK1G10.24761937
116FGFR10.23716180
117RAF10.23697432
118CDK140.22756062
119CHUK0.22459525
120RPS6KC10.22339914
121RPS6KL10.22339914
122CDK30.21945260
123GRK60.20187425
124GSK3B0.19498290
125RPS6KA60.18742873
126MAP3K60.18595848
127MAPK10.18565963
128MAP4K10.18405266
129STK390.18314859

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.19147484
2Mismatch repair_Homo sapiens_hsa034304.52329536
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54894112
4Homologous recombination_Homo sapiens_hsa034403.48072085
5Cell cycle_Homo sapiens_hsa041103.45266154
6RNA transport_Homo sapiens_hsa030133.19377027
7Base excision repair_Homo sapiens_hsa034103.14417843
8Spliceosome_Homo sapiens_hsa030403.06168417
9Fanconi anemia pathway_Homo sapiens_hsa034602.92269354
10Nucleotide excision repair_Homo sapiens_hsa034202.91139912
11One carbon pool by folate_Homo sapiens_hsa006702.83170166
12RNA polymerase_Homo sapiens_hsa030202.64755017
13Non-homologous end-joining_Homo sapiens_hsa034502.30223094
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17021489
15Ribosome_Homo sapiens_hsa030102.16093400
16Pyrimidine metabolism_Homo sapiens_hsa002402.14754104
17Basal transcription factors_Homo sapiens_hsa030221.98977273
18p53 signaling pathway_Homo sapiens_hsa041151.97763439
19Proteasome_Homo sapiens_hsa030501.96621479
20mRNA surveillance pathway_Homo sapiens_hsa030151.95731797
21RNA degradation_Homo sapiens_hsa030181.92090836
22Systemic lupus erythematosus_Homo sapiens_hsa053221.76996520
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51476172
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46831154
25Viral carcinogenesis_Homo sapiens_hsa052031.28556577
26Oocyte meiosis_Homo sapiens_hsa041141.25120460
27Protein export_Homo sapiens_hsa030601.24811760
28Pyruvate metabolism_Homo sapiens_hsa006201.24805760
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23719001
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23330055
31Epstein-Barr virus infection_Homo sapiens_hsa051691.20261044
32Purine metabolism_Homo sapiens_hsa002301.13896157
33Herpes simplex infection_Homo sapiens_hsa051681.09611298
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06161768
35Propanoate metabolism_Homo sapiens_hsa006401.04370831
36MicroRNAs in cancer_Homo sapiens_hsa052061.02683242
37Steroid biosynthesis_Homo sapiens_hsa001000.98516626
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97961206
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97527599
40Vitamin B6 metabolism_Homo sapiens_hsa007500.97519941
41HTLV-I infection_Homo sapiens_hsa051660.90913771
42Small cell lung cancer_Homo sapiens_hsa052220.85282005
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82475781
44Antigen processing and presentation_Homo sapiens_hsa046120.82222893
45Pentose phosphate pathway_Homo sapiens_hsa000300.79482610
46Huntingtons disease_Homo sapiens_hsa050160.74670131
47Alcoholism_Homo sapiens_hsa050340.73085774
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72414641
49Biosynthesis of amino acids_Homo sapiens_hsa012300.67670652
50Fatty acid elongation_Homo sapiens_hsa000620.66989033
51Thyroid cancer_Homo sapiens_hsa052160.66095896
52Parkinsons disease_Homo sapiens_hsa050120.64179533
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.63732877
54Colorectal cancer_Homo sapiens_hsa052100.61324355
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58748617
56Selenocompound metabolism_Homo sapiens_hsa004500.58324615
57Hippo signaling pathway_Homo sapiens_hsa043900.58166785
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58079553
59TGF-beta signaling pathway_Homo sapiens_hsa043500.58077334
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57752041
61Basal cell carcinoma_Homo sapiens_hsa052170.57440982
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56707168
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55319515
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.54514611
65Chronic myeloid leukemia_Homo sapiens_hsa052200.51964939
66Hepatitis B_Homo sapiens_hsa051610.51409226
67Apoptosis_Homo sapiens_hsa042100.49675903
68Legionellosis_Homo sapiens_hsa051340.48079111
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47699069
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.45976034
71Oxidative phosphorylation_Homo sapiens_hsa001900.45384452
72Adherens junction_Homo sapiens_hsa045200.45111564
73Folate biosynthesis_Homo sapiens_hsa007900.43919621
74Notch signaling pathway_Homo sapiens_hsa043300.43839707
75NF-kappa B signaling pathway_Homo sapiens_hsa040640.42778268
76Pancreatic cancer_Homo sapiens_hsa052120.41824568
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41617553
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41579725
79Sulfur relay system_Homo sapiens_hsa041220.41424668
80Pathways in cancer_Homo sapiens_hsa052000.39860288
81Viral myocarditis_Homo sapiens_hsa054160.39459095
82N-Glycan biosynthesis_Homo sapiens_hsa005100.39264323
83Bladder cancer_Homo sapiens_hsa052190.38687802
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37737819
85Measles_Homo sapiens_hsa051620.37348696
86Lysine degradation_Homo sapiens_hsa003100.36637116
87Primary immunodeficiency_Homo sapiens_hsa053400.36034943
88Prostate cancer_Homo sapiens_hsa052150.35853933
89Metabolic pathways_Homo sapiens_hsa011000.35759324
90Shigellosis_Homo sapiens_hsa051310.33983531
91Influenza A_Homo sapiens_hsa051640.33682061
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31089021
93mTOR signaling pathway_Homo sapiens_hsa041500.30237439
94Hedgehog signaling pathway_Homo sapiens_hsa043400.29117832
95Non-small cell lung cancer_Homo sapiens_hsa052230.26994304
96Arginine and proline metabolism_Homo sapiens_hsa003300.26379203
97FoxO signaling pathway_Homo sapiens_hsa040680.25803221
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25575998
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24738554
100Glutathione metabolism_Homo sapiens_hsa004800.24165043
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23700736
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23079436
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.22872559
104Melanoma_Homo sapiens_hsa052180.22378730
105HIF-1 signaling pathway_Homo sapiens_hsa040660.21586668
106Hematopoietic cell lineage_Homo sapiens_hsa046400.21261485
107Alzheimers disease_Homo sapiens_hsa050100.20260830
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.20259002
109Wnt signaling pathway_Homo sapiens_hsa043100.19559991
110Proteoglycans in cancer_Homo sapiens_hsa052050.19253249
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19204222
112Carbon metabolism_Homo sapiens_hsa012000.17058450
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.15549092
114Endometrial cancer_Homo sapiens_hsa052130.14752910
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.13703882
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12863062
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12381872
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12380834
119Fatty acid metabolism_Homo sapiens_hsa012120.11310287
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.11222819
121Leishmaniasis_Homo sapiens_hsa051400.11203083
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.07740929
123Acute myeloid leukemia_Homo sapiens_hsa052210.07652010
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07569966
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.07191514
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06947434
127Tight junction_Homo sapiens_hsa045300.06856455
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06425765
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.05275595
130Galactose metabolism_Homo sapiens_hsa000520.03962470
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.02643021

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