ERCC6L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.67277536
2mitotic sister chromatid cohesion (GO:0007064)5.86689741
3nuclear pore organization (GO:0006999)5.83153827
4nuclear pore complex assembly (GO:0051292)5.81024678
5regulation of RNA export from nucleus (GO:0046831)4.55810948
6DNA double-strand break processing (GO:0000729)4.51242079
7regulation of histone H3-K9 methylation (GO:0051570)4.32383628
8negative regulation of histone methylation (GO:0031061)4.31602883
9paraxial mesoderm development (GO:0048339)4.24707376
10monoubiquitinated protein deubiquitination (GO:0035520)4.18985785
11DNA unwinding involved in DNA replication (GO:0006268)4.14010099
12pre-miRNA processing (GO:0031054)4.07373910
13pore complex assembly (GO:0046931)4.04394583
14limb bud formation (GO:0060174)4.00957577
15somite development (GO:0061053)3.94091714
16protein localization to kinetochore (GO:0034501)3.75857248
17regulation of nucleobase-containing compound transport (GO:0032239)3.73122695
18folic acid-containing compound biosynthetic process (GO:0009396)3.70879547
19sister chromatid segregation (GO:0000819)3.63210902
20regulation of spindle organization (GO:0090224)3.62822694
21positive regulation of chromosome segregation (GO:0051984)3.59595382
22neural tube formation (GO:0001841)3.58394808
23mitotic nuclear envelope disassembly (GO:0007077)3.57441389
24positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51134075
25positive regulation of mitotic sister chromatid separation (GO:1901970)3.51134075
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51134075
27IMP biosynthetic process (GO:0006188)3.50941839
28meiotic chromosome segregation (GO:0045132)3.48650566
29mitotic chromosome condensation (GO:0007076)3.47233409
30histone H2A monoubiquitination (GO:0035518)3.45109110
31replication fork processing (GO:0031297)3.44510563
32negative regulation of DNA repair (GO:0045738)3.44314250
33pyrimidine nucleobase catabolic process (GO:0006208)3.38943988
34DNA geometric change (GO:0032392)3.37918062
35DNA duplex unwinding (GO:0032508)3.37553125
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.35795022
37regulation of sister chromatid cohesion (GO:0007063)3.34541627
38membrane disassembly (GO:0030397)3.34302787
39nuclear envelope disassembly (GO:0051081)3.34302787
40IMP metabolic process (GO:0046040)3.34271062
41resolution of meiotic recombination intermediates (GO:0000712)3.32420308
42positive regulation of oligodendrocyte differentiation (GO:0048714)3.31502348
43chromatin assembly (GO:0031497)3.27507601
44regulation of pigment cell differentiation (GO:0050932)3.27474631
45regulation of mitotic spindle organization (GO:0060236)3.25989503
46dosage compensation (GO:0007549)3.23851696
47histone H3-K9 modification (GO:0061647)3.23565891
48DNA integration (GO:0015074)3.20961957
49protein localization to chromosome, centromeric region (GO:0071459)3.19379815
50establishment of nucleus localization (GO:0040023)3.18950403
51regulation of centriole replication (GO:0046599)3.17763976
52mitotic metaphase plate congression (GO:0007080)3.17656657
53metaphase plate congression (GO:0051310)3.17492340
54protein localization to chromosome (GO:0034502)3.16493455
55microtubule anchoring (GO:0034453)3.16473609
56positive regulation of developmental pigmentation (GO:0048087)3.14789212
57peptidyl-lysine dimethylation (GO:0018027)3.13374200
58regulation of translational fidelity (GO:0006450)3.12454325
59histone H3-K9 methylation (GO:0051567)3.12041794
60non-recombinational repair (GO:0000726)3.11740055
61double-strand break repair via nonhomologous end joining (GO:0006303)3.11740055
62regulation of helicase activity (GO:0051095)3.11183497
63DNA topological change (GO:0006265)3.09531255
64mitotic sister chromatid segregation (GO:0000070)3.09465280
65phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08242194
66olfactory bulb development (GO:0021772)3.07315309
67intra-S DNA damage checkpoint (GO:0031573)3.04594458
68regulation of centrosome duplication (GO:0010824)3.04197771
69negative regulation of DNA recombination (GO:0045910)3.03934502
70establishment of protein localization to Golgi (GO:0072600)3.03697381
71cytoplasmic mRNA processing body assembly (GO:0033962)3.03253718
72regulation of centrosome cycle (GO:0046605)3.01582716
73microtubule depolymerization (GO:0007019)3.00624939
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.96203461
75somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96203461
76nucleus localization (GO:0051647)2.95561056
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.95503958
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.95503958
79translesion synthesis (GO:0019985)2.92846178
80alternative mRNA splicing, via spliceosome (GO:0000380)2.92423693
81negative regulation of translation, ncRNA-mediated (GO:0040033)2.91966858
82regulation of translation, ncRNA-mediated (GO:0045974)2.91966858
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91966858
84sister chromatid cohesion (GO:0007062)2.91243625
85centriole replication (GO:0007099)2.91167658
86kinetochore organization (GO:0051383)2.87451662
87neuron projection extension involved in neuron projection guidance (GO:1902284)2.87202264
88axon extension involved in axon guidance (GO:0048846)2.87202264
89regulation of transforming growth factor beta2 production (GO:0032909)2.86992644
90protein K6-linked ubiquitination (GO:0085020)2.85858044
91embryonic foregut morphogenesis (GO:0048617)2.85277134
92cerebral cortex radially oriented cell migration (GO:0021799)2.82230564
93regulation of translational termination (GO:0006449)2.81893858
94negative regulation of smooth muscle cell differentiation (GO:0051151)2.81503711
95negative regulation of chromatin modification (GO:1903309)2.81197845
96prenylation (GO:0097354)2.80919424
97protein prenylation (GO:0018342)2.80919424
98attachment of spindle microtubules to kinetochore (GO:0008608)2.80907330
99DNA replication initiation (GO:0006270)2.78824116
100maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78377278
101establishment of chromosome localization (GO:0051303)2.78256686
102positive regulation of histone H3-K4 methylation (GO:0051571)2.76088073
103histone H2A acetylation (GO:0043968)2.75884093
104DNA conformation change (GO:0071103)2.74570412
105pancreas development (GO:0031016)2.74319735
106interkinetic nuclear migration (GO:0022027)2.74177778
107heterochromatin organization (GO:0070828)2.73669793
108regulation of mRNA 3-end processing (GO:0031440)2.73210587
109central nervous system neuron axonogenesis (GO:0021955)2.72883472
110positive regulation of SMAD protein import into nucleus (GO:0060391)2.71501418
111regulation of mitotic spindle checkpoint (GO:1903504)2.70217392
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.70217392
113nucleobase catabolic process (GO:0046113)2.70093459
114DNA replication-dependent nucleosome organization (GO:0034723)2.69660250
115DNA replication-dependent nucleosome assembly (GO:0006335)2.69660250
116regulation of DNA endoreduplication (GO:0032875)2.69465926
117presynaptic membrane assembly (GO:0097105)2.68025206
118positive regulation of histone methylation (GO:0031062)2.67950561
119negative regulation of histone modification (GO:0031057)2.67869149
120chromatin remodeling at centromere (GO:0031055)2.67828806
121negative regulation of mRNA metabolic process (GO:1903312)2.67408512
122regulation of histone methylation (GO:0031060)2.66550745
123intraciliary transport (GO:0042073)2.66389565
124forebrain neuron differentiation (GO:0021879)2.65822932
125postreplication repair (GO:0006301)2.64993151
126negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64683946
127nuclear envelope organization (GO:0006998)2.64290625
128rRNA catabolic process (GO:0016075)2.62682243
129central nervous system projection neuron axonogenesis (GO:0021952)2.62591522
130peptidyl-lysine trimethylation (GO:0018023)2.61663047
131positive regulation of cell cycle checkpoint (GO:1901978)2.61423232
132chromatin silencing (GO:0006342)2.60515793
133protein targeting to Golgi (GO:0000042)2.60208280
134regulation of oligodendrocyte differentiation (GO:0048713)2.59493559
135response to pheromone (GO:0019236)2.58458627
136recombinational repair (GO:0000725)2.58083174
137regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.58057024
138positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.58057024
139gene silencing by RNA (GO:0031047)2.57740795
140gastrulation with mouth forming second (GO:0001702)2.57421718
141negative regulation of axon guidance (GO:1902668)2.57315077
142protein K11-linked deubiquitination (GO:0035871)2.56949118
143chromatin assembly or disassembly (GO:0006333)2.56170810
144DNA replication-independent nucleosome assembly (GO:0006336)2.56105493
145DNA replication-independent nucleosome organization (GO:0034724)2.56105493
146microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.56034088
147ganglion development (GO:0061548)2.55850642
148double-strand break repair via homologous recombination (GO:0000724)2.55815521
149establishment of mitotic spindle localization (GO:0040001)2.55070322
150CENP-A containing nucleosome assembly (GO:0034080)2.54864019
151retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53379313
152positive regulation of mRNA 3-end processing (GO:0031442)2.52714919
153chaperone-mediated protein complex assembly (GO:0051131)2.52289262
154regulation of histone H3-K27 methylation (GO:0061085)2.52219134
155histone mRNA catabolic process (GO:0071044)2.52150864
156regulation of chromosome segregation (GO:0051983)2.51635092
157genitalia morphogenesis (GO:0035112)2.51501110
158sympathetic nervous system development (GO:0048485)2.51092457
159nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.50322788
160artery development (GO:0060840)2.49960331
161regulation of mRNA catabolic process (GO:0061013)2.49625211
162spindle checkpoint (GO:0031577)2.49550889
163regulation of mitotic sister chromatid segregation (GO:0033047)2.49437032
164regulation of sister chromatid segregation (GO:0033045)2.49437032
165regulation of mitotic sister chromatid separation (GO:0010965)2.49437032
166cerebral cortex cell migration (GO:0021795)2.49382164
167pyrimidine dimer repair (GO:0006290)2.48598034
168histone H3-K4 trimethylation (GO:0080182)2.48003154
169atrial cardiac muscle cell action potential (GO:0086014)2.47957968
170microtubule organizing center organization (GO:0031023)2.47476329
171mitotic spindle checkpoint (GO:0071174)2.47475263
172reciprocal DNA recombination (GO:0035825)2.46204520
173reciprocal meiotic recombination (GO:0007131)2.46204520
174mitotic spindle assembly checkpoint (GO:0007094)2.44413607
175prostate gland growth (GO:0060736)2.44163180
176spindle assembly checkpoint (GO:0071173)2.43739070
177hindbrain development (GO:0030902)2.42695297
178negative chemotaxis (GO:0050919)2.42313668
179negative regulation of sister chromatid segregation (GO:0033046)2.42050613
180negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.42050613
181negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42050613
182negative regulation of mitotic sister chromatid segregation (GO:0033048)2.42050613
183negative regulation of mitotic sister chromatid separation (GO:2000816)2.42050613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.91769200
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.44355436
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.27867341
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.13404988
5E2F4_17652178_ChIP-ChIP_JURKAT_Human4.04615244
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.48389780
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.43357418
8IGF1R_20145208_ChIP-Seq_DFB_Human3.24703347
9AR_21909140_ChIP-Seq_LNCAP_Human3.17845098
10GBX2_23144817_ChIP-Seq_PC3_Human3.05946242
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97643705
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.85990089
13TAF15_26573619_Chip-Seq_HEK293_Human2.63384632
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61405091
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58495058
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.34516568
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30157516
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27480939
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.23971739
20ZNF274_21170338_ChIP-Seq_K562_Hela2.18227162
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13481966
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.10652432
23P300_19829295_ChIP-Seq_ESCs_Human2.10354979
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92219503
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.88960119
26SOX2_18555785_ChIP-Seq_MESCs_Mouse1.85734407
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85277439
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84515871
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.83960115
30SMAD4_21799915_ChIP-Seq_A2780_Human1.81734859
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80009891
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.79869893
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77887604
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75793427
35VDR_22108803_ChIP-Seq_LS180_Human1.74058110
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73537873
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73174776
38STAT3_23295773_ChIP-Seq_U87_Human1.72892255
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70868752
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70091864
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69673945
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.69194685
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68557600
44TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.66972507
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65148162
46ER_23166858_ChIP-Seq_MCF-7_Human1.62795558
47ELK1_19687146_ChIP-ChIP_HELA_Human1.61829307
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54341712
49CBP_20019798_ChIP-Seq_JUKART_Human1.54341712
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54237655
51CIITA_25753668_ChIP-Seq_RAJI_Human1.54111246
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53784963
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.53622531
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53529588
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53192354
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51144495
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50517800
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49293205
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49088470
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47520595
61TCF4_23295773_ChIP-Seq_U87_Human1.46007562
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44926124
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.43992003
64AR_21572438_ChIP-Seq_LNCaP_Human1.43562653
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42379467
66FUS_26573619_Chip-Seq_HEK293_Human1.40928175
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.40636227
68CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39322376
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38019554
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37434418
71AR_25329375_ChIP-Seq_VCAP_Human1.37303361
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36721235
73MYC_22102868_ChIP-Seq_BL_Human1.36349786
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.36290306
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31751491
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.31585307
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30738416
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.30288854
79KDM5A_27292631_Chip-Seq_BREAST_Human1.28382534
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27891172
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27690171
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27690171
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27666583
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27577996
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27561772
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24671155
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24597034
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23782457
89EWS_26573619_Chip-Seq_HEK293_Human1.23392415
90VDR_23849224_ChIP-Seq_CD4+_Human1.21749508
91BCAT_22108803_ChIP-Seq_LS180_Human1.20939435
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20486143
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19716517
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.19127783
95TP53_16413492_ChIP-PET_HCT116_Human1.18637453
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17972393
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17520215
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17024917
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16902317
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16902317
101HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16216972
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.16097060
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.15645113
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15173183
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.14906301
106NANOG_21062744_ChIP-ChIP_HESCs_Human1.14045098
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13890862
108TCF4_22108803_ChIP-Seq_LS180_Human1.12829693
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12695120
110P53_22387025_ChIP-Seq_ESCs_Mouse1.12470263
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12297800
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11650098
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.11624032
114SOX9_26525672_Chip-Seq_HEART_Mouse1.11350394
115CHD1_26751641_Chip-Seq_LNCaP_Human1.11017907
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.10766114
117RUNX2_22187159_ChIP-Seq_PCA_Human1.10051296
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09576428
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07388528
120TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06950777
121TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06898009
122CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06539548
123RNF2_27304074_Chip-Seq_NSC_Mouse1.06461506
124XRN2_22483619_ChIP-Seq_HELA_Human1.06343581
125CLOCK_20551151_ChIP-Seq_293T_Human1.06168779
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05487183
127CMYC_18555785_Chip-Seq_ESCs_Mouse1.04504309
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.03909509
129DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02821260
130SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02183647
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01620307
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01365416
133ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00847670
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.99829328
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.98897909
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.98703878
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98630552
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98239566
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98095974
140SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97979688
141SOX2_16153702_ChIP-ChIP_HESCs_Human0.97346680
142CRX_20693478_ChIP-Seq_RETINA_Mouse0.97189221
143TP53_18474530_ChIP-ChIP_U2OS_Human0.96810199
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96406526
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95795148
146BRD4_25478319_ChIP-Seq_HGPS_Human0.92471654
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.92278378
148POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91766345
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89841320
150KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89841320
151KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89841320
152ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89250079
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.88734293
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88202775
155NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85883032
156BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85718590
157FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85201364
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85191284
159E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84748753
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84674335
161TFEB_21752829_ChIP-Seq_HELA_Human0.84014964
162FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83850326
163FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83622933
164HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83554892
165POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83507149
166FOXP3_21729870_ChIP-Seq_TREG_Human0.82781985
167SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82550846
168IRF1_19129219_ChIP-ChIP_H3396_Human0.76410348
169GATA1_22025678_ChIP-Seq_K562_Human0.75365599
170CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74994204
171TTF2_22483619_ChIP-Seq_HELA_Human0.73803596
172TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.73425739
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72862679
174ISL1_27105846_Chip-Seq_CPCs_Mouse0.72647282
175ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72215117
176FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.71907006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.57806442
2MP0002102_abnormal_ear_morphology3.65161324
3MP0008057_abnormal_DNA_replication3.56262021
4MP0010094_abnormal_chromosome_stability3.08385250
5MP0002234_abnormal_pharynx_morphology2.92608527
6MP0010352_gastrointestinal_tract_polyps2.49857497
7MP0003077_abnormal_cell_cycle2.24068724
8MP0003123_paternal_imprinting2.23717400
9MP0003121_genomic_imprinting2.21997168
10MP0003787_abnormal_imprinting2.21966883
11MP0003693_abnormal_embryo_hatching2.21026630
12MP0003111_abnormal_nucleus_morphology2.18919677
13MP0002877_abnormal_melanocyte_morpholog2.18238984
14MP0004957_abnormal_blastocyst_morpholog2.12677342
15MP0003806_abnormal_nucleotide_metabolis2.08630046
16MP0001730_embryonic_growth_arrest1.97872637
17MP0008007_abnormal_cellular_replicative1.97712196
18MP0000778_abnormal_nervous_system1.96749458
19MP0003705_abnormal_hypodermis_morpholog1.95219729
20MP0002233_abnormal_nose_morphology1.94801428
21MP0008877_abnormal_DNA_methylation1.93179841
22MP0001984_abnormal_olfaction1.90740832
23MP0010307_abnormal_tumor_latency1.89427450
24MP0003937_abnormal_limbs/digits/tail_de1.88167951
25MP0006292_abnormal_olfactory_placode1.87301559
26MP0001293_anophthalmia1.86555578
27MP0010030_abnormal_orbit_morphology1.83080679
28MP0002084_abnormal_developmental_patter1.82884832
29MP0004197_abnormal_fetal_growth/weight/1.82300926
30MP0002009_preneoplasia1.77088925
31MP0000350_abnormal_cell_proliferation1.69966077
32MP0005248_abnormal_Harderian_gland1.65289273
33MP0003890_abnormal_embryonic-extraembry1.64687602
34MP0005380_embryogenesis_phenotype1.62196322
35MP0001672_abnormal_embryogenesis/_devel1.62196322
36MP0000537_abnormal_urethra_morphology1.61826485
37MP0002751_abnormal_autonomic_nervous1.60504617
38MP0003984_embryonic_growth_retardation1.60487952
39MP0002088_abnormal_embryonic_growth/wei1.59857912
40MP0000733_abnormal_muscle_development1.58753699
41MP0001697_abnormal_embryo_size1.58398487
42MP0001529_abnormal_vocalization1.57341027
43MP0002085_abnormal_embryonic_tissue1.57328672
44MP0003283_abnormal_digestive_organ1.56438547
45MP0010678_abnormal_skin_adnexa1.55650211
46MP0000631_abnormal_neuroendocrine_gland1.53691145
47MP0004264_abnormal_extraembryonic_tissu1.53589296
48MP0005253_abnormal_eye_physiology1.53362723
49MP0001188_hyperpigmentation1.46758393
50MP0004134_abnormal_chest_morphology1.45179509
51MP0009697_abnormal_copulation1.44881608
52MP0006054_spinal_hemorrhage1.42675714
53MP0008789_abnormal_olfactory_epithelium1.38797011
54MP0002086_abnormal_extraembryonic_tissu1.36783552
55MP0000566_synostosis1.35565665
56MP0002653_abnormal_ependyma_morphology1.33638300
57MP0009703_decreased_birth_body1.32848879
58MP0008932_abnormal_embryonic_tissue1.29743543
59MP0005076_abnormal_cell_differentiation1.28861612
60MP0002938_white_spotting1.28619728
61MP0000428_abnormal_craniofacial_morphol1.27516613
62MP0000432_abnormal_head_morphology1.26221149
63MP0002108_abnormal_muscle_morphology1.24588144
64MP0005367_renal/urinary_system_phenotyp1.24381759
65MP0000516_abnormal_urinary_system1.24381759
66MP0005391_vision/eye_phenotype1.24162342
67MP0002080_prenatal_lethality1.23495078
68MP0005499_abnormal_olfactory_system1.23200040
69MP0005394_taste/olfaction_phenotype1.23200040
70MP0003950_abnormal_plasma_membrane1.21872287
71MP0001299_abnormal_eye_distance/1.21646697
72MP0000003_abnormal_adipose_tissue1.20368620
73MP0005187_abnormal_penis_morphology1.18877973
74MP0000383_abnormal_hair_follicle1.18357615
75MP0003935_abnormal_craniofacial_develop1.17662856
76MP0002111_abnormal_tail_morphology1.16936199
77MP0002396_abnormal_hematopoietic_system1.16716456
78MP0008058_abnormal_DNA_repair1.15010186
79MP0002697_abnormal_eye_size1.14302860
80MP0002638_abnormal_pupillary_reflex1.13020460
81MP0002092_abnormal_eye_morphology1.11600624
82MP0008438_abnormal_cutaneous_collagen1.10324940
83MP0002166_altered_tumor_susceptibility1.10284188
84MP0004133_heterotaxia1.10118799
85MP0005220_abnormal_exocrine_pancreas1.09916617
86MP0004924_abnormal_behavior1.09753523
87MP0005386_behavior/neurological_phenoty1.09753523
88MP0010234_abnormal_vibrissa_follicle1.08527040
89MP0002095_abnormal_skin_pigmentation1.08334256
90MP0004270_analgesia1.08137532
91MP0009672_abnormal_birth_weight1.08084696
92MP0009046_muscle_twitch1.08031241
93MP0003385_abnormal_body_wall1.05959527
94MP0002210_abnormal_sex_determination1.05952865
95MP0003567_abnormal_fetal_cardiomyocyte1.04545077
96MP0000049_abnormal_middle_ear1.04355332
97MP0004808_abnormal_hematopoietic_stem1.04299267
98MP0003115_abnormal_respiratory_system1.04224369
99MP0003938_abnormal_ear_development1.03316329
100MP0008995_early_reproductive_senescence1.00016545
101MP0002184_abnormal_innervation0.99946832
102MP0002932_abnormal_joint_morphology0.99592125
103MP0009384_cardiac_valve_regurgitation0.99472005
104MP0001286_abnormal_eye_development0.98600396
105MP0002160_abnormal_reproductive_system0.98104201
106MP0006072_abnormal_retinal_apoptosis0.97048951
107MP0009250_abnormal_appendicular_skeleto0.96940002
108MP0001929_abnormal_gametogenesis0.96828066
109MP0002925_abnormal_cardiovascular_devel0.96329622
110MP0001346_abnormal_lacrimal_gland0.96328583
111MP0005503_abnormal_tendon_morphology0.96311882
112MP0002928_abnormal_bile_duct0.95475645
113MP0001177_atelectasis0.94905042
114MP0003755_abnormal_palate_morphology0.94693486
115MP0000427_abnormal_hair_cycle0.94068285
116MP0002896_abnormal_bone_mineralization0.93881316
117MP0005551_abnormal_eye_electrophysiolog0.92454141
118MP0002114_abnormal_axial_skeleton0.91920981
119MP0005508_abnormal_skeleton_morphology0.91883103
120MP0005408_hypopigmentation0.90727796
121MP0001486_abnormal_startle_reflex0.90285775
122MP0003221_abnormal_cardiomyocyte_apopto0.89699346
123MP0003300_gastrointestinal_ulcer0.89574812
124MP0005171_absent_coat_pigmentation0.89443097
125MP0000647_abnormal_sebaceous_gland0.88815771
126MP0003119_abnormal_digestive_system0.88166367
127MP0001145_abnormal_male_reproductive0.87777682
128MP0005084_abnormal_gallbladder_morpholo0.87240233
129MP0005623_abnormal_meninges_morphology0.85068594
130MP0000955_abnormal_spinal_cord0.84599577
131MP0002177_abnormal_outer_ear0.84145903
132MP0003195_calcinosis0.84138415
133MP0005645_abnormal_hypothalamus_physiol0.83878136
134MP0002282_abnormal_trachea_morphology0.83849812
135MP0002109_abnormal_limb_morphology0.83404182
136MP0003880_abnormal_central_pattern0.82120156
137MP0006276_abnormal_autonomic_nervous0.81917532
138MP0002152_abnormal_brain_morphology0.80929996
139MP0004215_abnormal_myocardial_fiber0.80442408
140MP0003136_yellow_coat_color0.80104594
141MP0003943_abnormal_hepatobiliary_system0.79806312
142MP0000163_abnormal_cartilage_morphology0.79624148
143MP0004811_abnormal_neuron_physiology0.78695525
144MP0003861_abnormal_nervous_system0.78072612
145MP0000462_abnormal_digestive_system0.77781067
146MP0000653_abnormal_sex_gland0.77197504
147MP0005389_reproductive_system_phenotype0.76494420
148MP0002557_abnormal_social/conspecific_i0.76005056
149MP0005195_abnormal_posterior_eye0.75592257
150MP0003698_abnormal_male_reproductive0.74645135
151MP0002752_abnormal_somatic_nervous0.72650731
152MP0002081_perinatal_lethality0.72413494
153MP0002882_abnormal_neuron_morphology0.71640753

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.61296348
2Volvulus (HP:0002580)3.41318674
3Small epiphyses (HP:0010585)3.14912658
4Hypoplastic ischia (HP:0003175)3.05534508
5Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.90370225
6Hypoplastic labia majora (HP:0000059)2.89782496
7Drooling (HP:0002307)2.88892429
8Neoplasm of the oral cavity (HP:0100649)2.83199291
9Hyperventilation (HP:0002883)2.74561991
10Oligodactyly (hands) (HP:0001180)2.72886305
11Pancreatic cysts (HP:0001737)2.69942019
12Abnormality of the ischium (HP:0003174)2.67752427
13Short 4th metacarpal (HP:0010044)2.66206431
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66206431
15Colon cancer (HP:0003003)2.64092881
16Long clavicles (HP:0000890)2.61417032
17Excessive salivation (HP:0003781)2.59839200
18Epiphyseal dysplasia (HP:0002656)2.57081466
19Abnormality of the labia majora (HP:0012881)2.55152463
20Chronic hepatic failure (HP:0100626)2.54898309
21Intestinal atresia (HP:0011100)2.50356818
22Abnormal foot bone ossification (HP:0010675)2.49628581
23True hermaphroditism (HP:0010459)2.46785548
24Abnormality of the phalanges of the 2nd finger (HP:0009541)2.42515552
25Selective tooth agenesis (HP:0001592)2.34948029
26Pancreatic fibrosis (HP:0100732)2.33826093
27Vertebral clefting (HP:0008428)2.32168516
28Lissencephaly (HP:0001339)2.31863558
29Tented upper lip vermilion (HP:0010804)2.31539863
30Renal cortical cysts (HP:0000803)2.31382113
31Esophageal atresia (HP:0002032)2.29875834
32Biliary tract neoplasm (HP:0100574)2.26489969
33Skull defect (HP:0001362)2.25731695
34Abnormality of the renal medulla (HP:0100957)2.24909862
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.21023079
36Thyroid carcinoma (HP:0002890)2.20500829
37Abnormality of midbrain morphology (HP:0002418)2.19848298
38Molar tooth sign on MRI (HP:0002419)2.19848298
39Abnormality of the renal cortex (HP:0011035)2.18441440
40Nephronophthisis (HP:0000090)2.18331511
41Medial flaring of the eyebrow (HP:0010747)2.15781530
42Protruding tongue (HP:0010808)2.15164739
43Missing ribs (HP:0000921)2.15093659
44Fair hair (HP:0002286)2.14891916
45Increased nuchal translucency (HP:0010880)2.14243589
46Bifid tongue (HP:0010297)2.12422751
47Facial hemangioma (HP:0000329)2.09635938
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.08781533
49Large earlobe (HP:0009748)2.08404834
50Thyroiditis (HP:0100646)2.06962336
51Prominent occiput (HP:0000269)2.06256221
52Absent speech (HP:0001344)2.06249032
53Deviation of the thumb (HP:0009603)2.05534846
54Aplasia/Hypoplasia of the sternum (HP:0006714)2.05120631
55Supernumerary spleens (HP:0009799)2.03068268
56Ependymoma (HP:0002888)2.03050384
57Macroorchidism (HP:0000053)2.02359871
58Cerebellar dysplasia (HP:0007033)2.02319834
59Stenosis of the external auditory canal (HP:0000402)2.00309514
60Abnormal hair whorl (HP:0010721)1.99319192
61Nephrogenic diabetes insipidus (HP:0009806)1.98971604
62Gaze-evoked nystagmus (HP:0000640)1.98699345
63Rhizomelia (HP:0008905)1.98166510
64Hip dysplasia (HP:0001385)1.97760812
65Bell-shaped thorax (HP:0001591)1.96955807
66Shallow orbits (HP:0000586)1.96939420
67Congenital primary aphakia (HP:0007707)1.96745260
68Broad thumb (HP:0011304)1.96544673
69Rhabdomyosarcoma (HP:0002859)1.96109476
70Postaxial foot polydactyly (HP:0001830)1.95936275
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.95157074
72Abnormality of the ileum (HP:0001549)1.94150002
73Abnormality of the fingertips (HP:0001211)1.93802342
74Tubulointerstitial nephritis (HP:0001970)1.93160138
75Proximal placement of thumb (HP:0009623)1.93143531
76Genital tract atresia (HP:0001827)1.92611297
77Gait imbalance (HP:0002141)1.90603444
78Rectal prolapse (HP:0002035)1.90595509
79Supernumerary ribs (HP:0005815)1.90083874
80Curly hair (HP:0002212)1.89972073
81Papillary thyroid carcinoma (HP:0002895)1.89261878
82Absent frontal sinuses (HP:0002688)1.89171295
83Neoplasm of the adrenal cortex (HP:0100641)1.89125424
84Cystic hygroma (HP:0000476)1.88517093
85Abnormal vertebral ossification (HP:0100569)1.88117587
86Hypoplastic iliac wings (HP:0002866)1.87979258
87Limited elbow extension (HP:0001377)1.87828227
88Type II lissencephaly (HP:0007260)1.87677198
89Short ribs (HP:0000773)1.87503110
90Meckel diverticulum (HP:0002245)1.87443098
91Medulloblastoma (HP:0002885)1.87120182
92Basal cell carcinoma (HP:0002671)1.86894501
93Mild short stature (HP:0003502)1.86476204
94Hepatoblastoma (HP:0002884)1.86171733
95Vaginal atresia (HP:0000148)1.83309611
96Broad-based gait (HP:0002136)1.83131659
97Alacrima (HP:0000522)1.83005123
98Preaxial foot polydactyly (HP:0001841)1.82785298
99Small hand (HP:0200055)1.82534117
100Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82531894
101Broad phalanges of the hand (HP:0009768)1.82246972
102Astrocytoma (HP:0009592)1.81665492
103Abnormality of the astrocytes (HP:0100707)1.81665492
104Gonadotropin excess (HP:0000837)1.80783449
105Genetic anticipation (HP:0003743)1.79873980
106Atonic seizures (HP:0010819)1.79339883
107Oligodactyly (HP:0012165)1.79027479
108Preaxial hand polydactyly (HP:0001177)1.78839258
109Anophthalmia (HP:0000528)1.78811932
110Widely spaced teeth (HP:0000687)1.78407156
111Progressive inability to walk (HP:0002505)1.78293012
112Pancreatic islet-cell hyperplasia (HP:0004510)1.78160363
113Deep philtrum (HP:0002002)1.77394893
114Decreased lacrimation (HP:0000633)1.77303054
115Neoplasm of the small intestine (HP:0100833)1.76511552
116Increased density of long bones (HP:0006392)1.76421218
117Ectopic kidney (HP:0000086)1.74187421
118Poor coordination (HP:0002370)1.74013889
119Birth length less than 3rd percentile (HP:0003561)1.73951791
120Labial hypoplasia (HP:0000066)1.73059846
121Abnormal biliary tract morphology (HP:0012440)1.72864683
122Hypoplastic female external genitalia (HP:0012815)1.72353287
123Chromsome breakage (HP:0040012)1.71934569
124Abnormality of the corticospinal tract (HP:0002492)1.71882311
125Gastrointestinal atresia (HP:0002589)1.71783965
12611 pairs of ribs (HP:0000878)1.71742546
127Abnormality of the 4th metacarpal (HP:0010012)1.71713487
128Micropenis (HP:0000054)1.70923939
129Malignant gastrointestinal tract tumors (HP:0006749)1.70755958
130Gastrointestinal carcinoma (HP:0002672)1.70755958
131Postaxial hand polydactyly (HP:0001162)1.70150036
132Truncal obesity (HP:0001956)1.69825346
133Synostosis of carpal bones (HP:0005048)1.68965394
134Ulnar bowing (HP:0003031)1.68845959
135Heterotopia (HP:0002282)1.68178134
136Neoplasm of striated muscle (HP:0009728)1.67968527
137Broad phalanx (HP:0006009)1.67927932
138Growth hormone deficiency (HP:0000824)1.67649482
139Hypochromic microcytic anemia (HP:0004840)1.67497314
140Abnormality of the 2nd finger (HP:0004100)1.67116617
141Hypoplastic scapulae (HP:0000882)1.66777430
142Aplasia/Hypoplasia of the scapulae (HP:0006713)1.66777430
143Sandal gap (HP:0001852)1.66772963
144Cortical dysplasia (HP:0002539)1.66452110
145Ovarian neoplasm (HP:0100615)1.66139386
146Specific learning disability (HP:0001328)1.65865325
147Embryonal renal neoplasm (HP:0011794)1.65677743
148Termporal pattern (HP:0011008)1.65044658
149Insidious onset (HP:0003587)1.65044658
150Supernumerary bones of the axial skeleton (HP:0009144)1.65037344
151Abnormality of chromosome stability (HP:0003220)1.64823928
152Degeneration of the lateral corticospinal tracts (HP:0002314)1.64737260
153Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64737260
154Rib fusion (HP:0000902)1.64341822
155Sloping forehead (HP:0000340)1.64253068
156Abnormality of the incisor (HP:0000676)1.64059427
157Abnormality of the pancreatic islet cells (HP:0006476)1.63926313
158Abnormality of endocrine pancreas physiology (HP:0012093)1.63926313
159Bilateral microphthalmos (HP:0007633)1.63575538
160Long eyelashes (HP:0000527)1.62624322
161Abnormality of the pubic bones (HP:0003172)1.61703514
162Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61503055
163Abnormality of chromosome segregation (HP:0002916)1.60896891
164Carpal bone hypoplasia (HP:0001498)1.60730553
165Abnormality of the parietal bone (HP:0002696)1.60014686
166Broad long bones (HP:0005622)1.59822215
167Glioma (HP:0009733)1.59019188
168Obsessive-compulsive behavior (HP:0000722)1.58803120
169Hemivertebrae (HP:0002937)1.58364790
170Atresia of the external auditory canal (HP:0000413)1.57453164
171Abnormality of the salivary glands (HP:0010286)1.57003560
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.56562456
173Relative macrocephaly (HP:0004482)1.56475967

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.76298945
2LATS13.53707912
3CDC73.29773112
4MAP3K43.06239679
5BRD42.92324993
6FGFR22.62260645
7STK32.47493043
8TRIM282.41022309
9CASK2.31707220
10MAP4K22.28238704
11WNK32.22893439
12PNCK2.17258178
13BMPR1B2.08294684
14ERBB32.02636706
15NEK21.99616314
16ACVR1B1.92436850
17CAMK1D1.89098414
18SCYL21.87835199
19MAP2K71.84335053
20MAPK131.81758323
21EIF2AK31.80733774
22CAMK1G1.76580327
23SRPK11.74444229
24TTK1.60571822
25PASK1.56045998
26PLK31.49977402
27TNIK1.48896324
28ATR1.44015319
29CCNB11.44002370
30FRK1.43001994
31MARK11.42709940
32BUB11.42538584
33MKNK11.40956150
34EPHA31.37451429
35CHEK11.31679038
36PLK41.31333888
37ATM1.31126698
38VRK11.30153841
39RPS6KB21.26749975
40EPHA41.26597068
41MET1.26314771
42WEE11.24669501
43DYRK31.23215036
44EEF2K1.22197423
45NLK1.20902253
46PRKD31.20624663
47EPHB11.19175294
48PDGFRA1.18518811
49MELK1.18412181
50CSNK1A1L1.14708758
51SIK11.13667335
52FGFR11.12858813
53STK101.12771124
54CHEK21.11703015
55MAPK151.11430979
56CDK61.10297275
57AKT31.07441139
58MTOR1.04834245
59CDK41.03867155
60CDK71.03537846
61FGFR31.03267558
62EPHA21.02924588
63SGK21.00795925
64OXSR11.00401156
65AURKB0.99153711
66CDK90.95575284
67CSNK1D0.95184523
68STK40.94146274
69WNK10.93031834
70PTK60.90873956
71PLK20.90737227
72MAP2K40.90054955
73RPS6KA50.89248090
74TESK20.86310657
75EIF2AK10.85836850
76MAP3K100.85498141
77PBK0.84524241
78NEK90.83987475
79PINK10.83269782
80ALK0.82178504
81CDK20.81215236
82TTN0.80885812
83RPS6KA40.79655306
84STK240.78875501
85PLK10.78463754
86BRSK20.76131105
87CSNK1G10.73838843
88PRKDC0.73621886
89MAP3K80.73550731
90STK38L0.72623993
91NTRK20.71627298
92CAMKK20.71169658
93MAP3K60.70646112
94CDK10.70483094
95CDK30.70370394
96OBSCN0.70214083
97PAK30.69491969
98IRAK10.67155947
99TAOK30.65724629
100NUAK10.65500831
101PRKCE0.64842833
102STK390.63920580
103PIK3CG0.62530060
104TGFBR10.61911576
105INSRR0.61655178
106GSK3A0.60193013
107BCR0.59619950
108PDGFRB0.57257592
109MAPK140.55672493
110PRKAA20.53992301
111MAPK10.53955497
112DYRK1A0.53544897
113PKN20.52903657
114MARK30.52347483
115CSNK1E0.52042662
116PRKCH0.51539210
117CSNK1G30.50955900
118ERBB40.50754607
119LRRK20.50263764
120MKNK20.49679062
121MAPKAPK50.49666821
122ITK0.49433303
123STK380.49251361
124MAPK100.48356505
125MAP4K10.47761799
126PIK3CA0.47706645
127SGK2230.47351293
128SGK4940.47351293
129CSNK1G20.46500745
130PRPF4B0.46229983
131CAMK40.46164647
132TRPM70.46058379
133TLK10.45690823
134KSR10.45460321
135DYRK20.43870763
136GSK3B0.43624239
137PAK20.43543130
138TSSK60.42675323
139HIPK20.42601952
140FLT30.41567132
141PRKACB0.40443015
142FGFR40.39206316
143YES10.38594405
144SGK30.38590735
145UHMK10.37421156
146ZAK0.36980365
147CSNK2A20.36896234
148RAF10.35298073
149MAP3K50.34857549
150PRKCG0.34759593
151NEK60.33877407
152DMPK0.33803311
153TEC0.33517328

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.24716818
2Cell cycle_Homo sapiens_hsa041102.94147125
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.74046014
4DNA replication_Homo sapiens_hsa030302.57607343
5RNA transport_Homo sapiens_hsa030132.49770727
6Mismatch repair_Homo sapiens_hsa034302.48229880
7One carbon pool by folate_Homo sapiens_hsa006702.36621162
8Spliceosome_Homo sapiens_hsa030402.23603186
9mRNA surveillance pathway_Homo sapiens_hsa030152.23552982
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18617530
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08010126
12RNA degradation_Homo sapiens_hsa030182.06786888
13Basal transcription factors_Homo sapiens_hsa030221.95845997
14Butanoate metabolism_Homo sapiens_hsa006501.89193955
15Fanconi anemia pathway_Homo sapiens_hsa034601.88573670
16Lysine degradation_Homo sapiens_hsa003101.81901584
17Nicotine addiction_Homo sapiens_hsa050331.77928234
18Basal cell carcinoma_Homo sapiens_hsa052171.69612290
19Homologous recombination_Homo sapiens_hsa034401.63993800
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58869679
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58059730
22MicroRNAs in cancer_Homo sapiens_hsa052061.57368094
23Viral carcinogenesis_Homo sapiens_hsa052031.53770395
24Systemic lupus erythematosus_Homo sapiens_hsa053221.50720863
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49729247
26Nitrogen metabolism_Homo sapiens_hsa009101.48886698
27Regulation of autophagy_Homo sapiens_hsa041401.48371393
28Prostate cancer_Homo sapiens_hsa052151.47107479
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47069054
30Nucleotide excision repair_Homo sapiens_hsa034201.44623874
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.44360004
32Circadian rhythm_Homo sapiens_hsa047101.38775347
33Phototransduction_Homo sapiens_hsa047441.37015788
34Taste transduction_Homo sapiens_hsa047421.36654141
35Notch signaling pathway_Homo sapiens_hsa043301.33619934
36Steroid biosynthesis_Homo sapiens_hsa001001.32571757
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.31108467
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27751751
39Hippo signaling pathway_Homo sapiens_hsa043901.27302984
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27191921
41Hedgehog signaling pathway_Homo sapiens_hsa043401.26291878
42TGF-beta signaling pathway_Homo sapiens_hsa043501.24428022
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23298988
44Base excision repair_Homo sapiens_hsa034101.21943609
45Small cell lung cancer_Homo sapiens_hsa052221.18192139
46p53 signaling pathway_Homo sapiens_hsa041151.17218415
47HTLV-I infection_Homo sapiens_hsa051661.16007115
48Selenocompound metabolism_Homo sapiens_hsa004501.14295254
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13326847
50ECM-receptor interaction_Homo sapiens_hsa045121.10209044
51Protein export_Homo sapiens_hsa030601.09367116
52Dopaminergic synapse_Homo sapiens_hsa047281.05864627
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04697869
54Adherens junction_Homo sapiens_hsa045201.04668507
55GABAergic synapse_Homo sapiens_hsa047271.01305391
56Dorso-ventral axis formation_Homo sapiens_hsa043201.00783794
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98820361
58Proteoglycans in cancer_Homo sapiens_hsa052050.97677451
59Long-term depression_Homo sapiens_hsa047300.97493551
60Sulfur metabolism_Homo sapiens_hsa009200.97384363
61Renal cell carcinoma_Homo sapiens_hsa052110.96289528
62Axon guidance_Homo sapiens_hsa043600.95954955
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92473569
64Alcoholism_Homo sapiens_hsa050340.92339726
65Chronic myeloid leukemia_Homo sapiens_hsa052200.91246496
66Circadian entrainment_Homo sapiens_hsa047130.90216946
67Glucagon signaling pathway_Homo sapiens_hsa049220.89954837
68Herpes simplex infection_Homo sapiens_hsa051680.89820595
69Oocyte meiosis_Homo sapiens_hsa041140.89466316
70Wnt signaling pathway_Homo sapiens_hsa043100.88855069
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85619468
72Tight junction_Homo sapiens_hsa045300.84485211
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83587862
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82307738
75Thyroid cancer_Homo sapiens_hsa052160.81831230
76Pathways in cancer_Homo sapiens_hsa052000.81801064
77Glutamatergic synapse_Homo sapiens_hsa047240.81617090
78Sphingolipid metabolism_Homo sapiens_hsa006000.80589114
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80536763
80Colorectal cancer_Homo sapiens_hsa052100.80003951
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76971244
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75462429
83Antigen processing and presentation_Homo sapiens_hsa046120.71607733
84Morphine addiction_Homo sapiens_hsa050320.70885953
85Focal adhesion_Homo sapiens_hsa045100.70848945
86Non-small cell lung cancer_Homo sapiens_hsa052230.70828594
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70258943
88Olfactory transduction_Homo sapiens_hsa047400.70137135
89Gap junction_Homo sapiens_hsa045400.69645047
90N-Glycan biosynthesis_Homo sapiens_hsa005100.65748548
91Epstein-Barr virus infection_Homo sapiens_hsa051690.63361720
92PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61465623
93Serotonergic synapse_Homo sapiens_hsa047260.61019295
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60750073
95Fatty acid metabolism_Homo sapiens_hsa012120.60672760
96Pancreatic cancer_Homo sapiens_hsa052120.60160403
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59869445
98Choline metabolism in cancer_Homo sapiens_hsa052310.59574033
99RNA polymerase_Homo sapiens_hsa030200.58783226
100Prolactin signaling pathway_Homo sapiens_hsa049170.58768167
101Bladder cancer_Homo sapiens_hsa052190.58348904
102Hepatitis B_Homo sapiens_hsa051610.58283425
103Pyrimidine metabolism_Homo sapiens_hsa002400.57805323
104ABC transporters_Homo sapiens_hsa020100.57537423
105Cholinergic synapse_Homo sapiens_hsa047250.56425681
106B cell receptor signaling pathway_Homo sapiens_hsa046620.54728670
107Purine metabolism_Homo sapiens_hsa002300.54162121
108ErbB signaling pathway_Homo sapiens_hsa040120.54067322
109FoxO signaling pathway_Homo sapiens_hsa040680.53490261
110mTOR signaling pathway_Homo sapiens_hsa041500.52713340
111Peroxisome_Homo sapiens_hsa041460.52396923
112Amphetamine addiction_Homo sapiens_hsa050310.52197865
113AMPK signaling pathway_Homo sapiens_hsa041520.50911308
114Primary immunodeficiency_Homo sapiens_hsa053400.50529640
115Vitamin B6 metabolism_Homo sapiens_hsa007500.49409970
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.49208513
117Thyroid hormone synthesis_Homo sapiens_hsa049180.47942029
118cAMP signaling pathway_Homo sapiens_hsa040240.47035801
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46437408
120Inositol phosphate metabolism_Homo sapiens_hsa005620.45928008
121Fatty acid biosynthesis_Homo sapiens_hsa000610.45422714
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45154965
123Protein digestion and absorption_Homo sapiens_hsa049740.44721488
124Insulin resistance_Homo sapiens_hsa049310.44484317
125Endometrial cancer_Homo sapiens_hsa052130.43881659
126Steroid hormone biosynthesis_Homo sapiens_hsa001400.43540172
127Melanogenesis_Homo sapiens_hsa049160.42334390
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42005625
129Type II diabetes mellitus_Homo sapiens_hsa049300.39781927
130Salivary secretion_Homo sapiens_hsa049700.39069469
131Renin secretion_Homo sapiens_hsa049240.38048049
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35408150
133Glioma_Homo sapiens_hsa052140.34779683
134Ether lipid metabolism_Homo sapiens_hsa005650.33990449
135Estrogen signaling pathway_Homo sapiens_hsa049150.33907191
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32367644
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31292382
138Propanoate metabolism_Homo sapiens_hsa006400.30847587
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.30253367
140Melanoma_Homo sapiens_hsa052180.29987311
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28451028
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27255258
143Caffeine metabolism_Homo sapiens_hsa002320.27088087

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