EREG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.82573257
2chondrocyte proliferation (GO:0035988)6.39552616
3skin morphogenesis (GO:0043589)6.34010393
4negative regulation of leukocyte chemotaxis (GO:0002689)5.57734759
5wound healing, spreading of epidermal cells (GO:0035313)5.45392928
6cell adhesion mediated by integrin (GO:0033627)5.38357030
7regulation of vitamin metabolic process (GO:0030656)5.32646602
8positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.26169351
9collagen fibril organization (GO:0030199)5.20183841
10mesenchymal-epithelial cell signaling (GO:0060638)5.14527737
11response to peptidoglycan (GO:0032494)4.99353344
12positive regulation of chemokine secretion (GO:0090197)4.71320115
13regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.68992985
14positive regulation of chemokine biosynthetic process (GO:0045080)4.63433723
15negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.63059247
16regulation of chemokine secretion (GO:0090196)4.62270431
17regulation of chronic inflammatory response (GO:0002676)4.61869063
18neutrophil activation involved in immune response (GO:0002283)4.60215212
19regulation of heat generation (GO:0031650)4.56961087
20regulation of interferon-alpha production (GO:0032647)4.56652077
21regulation of chemokine biosynthetic process (GO:0045073)4.47039279
22negative regulation of fatty acid transport (GO:2000192)4.38517245
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.33184163
24wound healing, spreading of cells (GO:0044319)4.29786502
25sequestering of extracellular ligand from receptor (GO:0035581)4.29420061
26regulation of monocyte chemotaxis (GO:0090025)4.26106421
27positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.24372029
28endodermal cell differentiation (GO:0035987)4.20133266
29cellular response to ATP (GO:0071318)4.19628781
30regulation of cytokine secretion involved in immune response (GO:0002739)4.19582471
31negative regulation of myeloid cell apoptotic process (GO:0033033)4.19548189
32positive regulation of NF-kappaB import into nucleus (GO:0042346)4.16317186
33positive regulation of interferon-alpha production (GO:0032727)4.04022425
34regulation of podosome assembly (GO:0071801)4.03655206
35positive regulation of macrophage activation (GO:0043032)4.02391918
36cell migration involved in sprouting angiogenesis (GO:0002042)3.99497483
37negative regulation of interleukin-12 production (GO:0032695)3.90768951
38regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.90100938
39regulation of T-helper 1 cell differentiation (GO:0045625)3.84644374
40positive regulation of endothelial cell apoptotic process (GO:2000353)3.84102571
41mesodermal cell differentiation (GO:0048333)3.83915196
42positive regulation of T-helper cell differentiation (GO:0045624)3.73933949
43regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68685525
44positive regulation of nitric oxide biosynthetic process (GO:0045429)3.65035294
45negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.58745920
46positive regulation of blood vessel endothelial cell migration (GO:0043536)3.58442600
47decidualization (GO:0046697)3.58006973
48cellular response to exogenous dsRNA (GO:0071360)3.56447009
49granulocyte activation (GO:0036230)3.56024257
50regulation of pigment cell differentiation (GO:0050932)3.53083252
51desmosome organization (GO:0002934)3.53027453
52regulation of heterotypic cell-cell adhesion (GO:0034114)3.50262059
53regulation of mononuclear cell migration (GO:0071675)3.50096385
54regulation of NF-kappaB import into nucleus (GO:0042345)3.49975638
55positive regulation of osteoblast proliferation (GO:0033690)3.48391548
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.45301897
57regulation of transforming growth factor beta1 production (GO:0032908)3.44338304
58regulation of nitric oxide biosynthetic process (GO:0045428)3.43653415
59response to protozoan (GO:0001562)3.43307954
60cellular response to vitamin D (GO:0071305)3.41898069
61T-helper 1 type immune response (GO:0042088)3.41047715
62modulation of growth of symbiont involved in interaction with host (GO:0044144)3.40434701
63regulation of growth of symbiont in host (GO:0044126)3.40434701
64negative regulation of growth of symbiont in host (GO:0044130)3.40434701
65negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.40434701
66protein localization to cell surface (GO:0034394)3.39551337
67axon extension involved in axon guidance (GO:0048846)3.39366575
68neuron projection extension involved in neuron projection guidance (GO:1902284)3.39366575
69positive regulation of interleukin-17 production (GO:0032740)3.37382006
70regulation of fever generation (GO:0031620)3.37156169
71regulation of myeloid cell apoptotic process (GO:0033032)3.33082399
72hemidesmosome assembly (GO:0031581)3.32184918
73positive regulation vascular endothelial growth factor production (GO:0010575)3.31372479
74positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29637406
75positive regulation of heat generation (GO:0031652)3.27908690
76cyclooxygenase pathway (GO:0019371)3.25715881
77regulation of vascular endothelial growth factor production (GO:0010574)3.25527672
78negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.25433379
79neutrophil activation (GO:0042119)3.24978685
80natural killer cell activation involved in immune response (GO:0002323)3.24753566
81* positive regulation of interleukin-6 production (GO:0032755)3.23163019
82response to muramyl dipeptide (GO:0032495)3.20731710
83hepatocyte differentiation (GO:0070365)3.20471678
84protein heterotrimerization (GO:0070208)3.20014960
85peptidyl-threonine dephosphorylation (GO:0035970)3.19054681
86positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.18482398
87positive regulation of interferon-beta production (GO:0032728)3.17547857
88hair cycle (GO:0042633)3.16494525
89molting cycle (GO:0042303)3.16494525
90negative regulation of nitric oxide biosynthetic process (GO:0045019)3.16406116
91positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.15546204
92negative regulation of lipid storage (GO:0010888)3.14410511
93positive regulation of transcription factor import into nucleus (GO:0042993)3.14122178
94positive regulation of monocyte chemotaxis (GO:0090026)3.13285215
95regulation of T-helper cell differentiation (GO:0045622)3.12118336
96response to ATP (GO:0033198)3.11941286
97peptide cross-linking (GO:0018149)3.09593615
98positive regulation of developmental pigmentation (GO:0048087)3.06937062
99regulation of interleukin-8 biosynthetic process (GO:0045414)3.06350020
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05217723
101plasma membrane repair (GO:0001778)3.05203786
102negative regulation of cytokine secretion (GO:0050710)3.04910136
103chronic inflammatory response (GO:0002544)3.04693521
104prostaglandin biosynthetic process (GO:0001516)3.04224194
105prostanoid biosynthetic process (GO:0046457)3.04224194
106apoptotic cell clearance (GO:0043277)3.03305883
107positive regulation of protein import into nucleus, translocation (GO:0033160)3.01167126
108positive regulation of transforming growth factor beta production (GO:0071636)2.99061495
109positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98931394
110defense response to protozoan (GO:0042832)2.97725832
111cellular response to lipopolysaccharide (GO:0071222)2.96041552
112response to manganese ion (GO:0010042)2.95156750
113cellular response to interferon-alpha (GO:0035457)2.94305549
114response to vitamin D (GO:0033280)2.94136496
115regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.92580561
116negative regulation of interleukin-8 production (GO:0032717)2.91976173
117cell-substrate junction assembly (GO:0007044)2.91656807
118branching involved in labyrinthine layer morphogenesis (GO:0060670)2.91020598
119positive regulation of acute inflammatory response (GO:0002675)2.88905175
120substrate-dependent cell migration (GO:0006929)2.88902276
121positive regulation of natural killer cell activation (GO:0032816)2.88700682
122epithelial cell-cell adhesion (GO:0090136)2.88598636
123cellular response to vitamin (GO:0071295)2.88498705
124positive regulation of interleukin-12 production (GO:0032735)2.88097113
125cellular response to nicotine (GO:0071316)2.87937088
126craniofacial suture morphogenesis (GO:0097094)2.87843530
127blood vessel endothelial cell migration (GO:0043534)2.87541553
128positive regulation of T-helper 1 type immune response (GO:0002827)2.87334351
129collagen metabolic process (GO:0032963)2.86145685
130regulation of interleukin-12 production (GO:0032655)2.85116353
131extracellular matrix disassembly (GO:0022617)2.84283156
132positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.84220396
133dermatan sulfate biosynthetic process (GO:0030208)2.83444504
134regulation of interleukin-17 production (GO:0032660)2.83264743
135response to exogenous dsRNA (GO:0043330)2.82146210
136negative regulation of fibrinolysis (GO:0051918)2.81648529
137positive regulation of protein autophosphorylation (GO:0031954)2.80943163
138regulation of water loss via skin (GO:0033561)2.80577009
139cellular response to molecule of bacterial origin (GO:0071219)2.80464288
140regulation of prostaglandin secretion (GO:0032306)2.80323849
141positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.79555264
142cranial suture morphogenesis (GO:0060363)2.79488122
143germinal center formation (GO:0002467)2.78997007
144* keratinocyte differentiation (GO:0030216)2.78879961
145natural killer cell mediated immunity (GO:0002228)2.78578699
146natural killer cell mediated cytotoxicity (GO:0042267)2.78578699
147regulation of histone phosphorylation (GO:0033127)2.78177482
148regulation of plasminogen activation (GO:0010755)2.78054053
149negative regulation of smooth muscle cell migration (GO:0014912)2.77972285
150regulation of chemokine-mediated signaling pathway (GO:0070099)2.77123188
151positive regulation of defense response to virus by host (GO:0002230)2.76625760
152positive regulation of chemokine production (GO:0032722)2.75514832
153collagen catabolic process (GO:0030574)2.74317193
154establishment of endothelial barrier (GO:0061028)2.73805504
155regulation of transforming growth factor beta production (GO:0071634)2.72905488
156endocardial cushion development (GO:0003197)2.72887223
157neutrophil mediated immunity (GO:0002446)2.72071119
158regulation of integrin-mediated signaling pathway (GO:2001044)2.69998753
159oligosaccharide catabolic process (GO:0009313)2.69620542
160lymphangiogenesis (GO:0001946)2.69377787
161negative regulation of interleukin-17 production (GO:0032700)2.68779676
162positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.66965401
163regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.66965401
164multicellular organismal macromolecule metabolic process (GO:0044259)2.66961161
165hippo signaling (GO:0035329)2.66690178
166positive regulation of astrocyte differentiation (GO:0048711)2.65976824
167cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.65375064
168positive regulation of macrophage differentiation (GO:0045651)2.65263066
169establishment of skin barrier (GO:0061436)2.64377957
170regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.64099458
171positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63613845
172negative regulation of biomineral tissue development (GO:0070168)2.63016459
173regulation of membrane protein ectodomain proteolysis (GO:0051043)2.62919879
174regulation of interleukin-8 secretion (GO:2000482)2.62804363
175response to dsRNA (GO:0043331)2.62272447
176regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.60939842
177regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.60615536
178regulation of immunoglobulin secretion (GO:0051023)2.60003428
179negative regulation of cytokine production involved in immune response (GO:0002719)2.58892420
180regulation of response to interferon-gamma (GO:0060330)2.58837937
181negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58685096
182positive regulation of interleukin-10 production (GO:0032733)2.57954394
183* regulation of interleukin-6 production (GO:0032675)2.57448081
184regulation of macrophage chemotaxis (GO:0010758)2.57152987
185dermatan sulfate metabolic process (GO:0030205)2.56646361
186substrate adhesion-dependent cell spreading (GO:0034446)2.54745962
187regulation of osteoblast proliferation (GO:0033688)2.54539181
188stress fiber assembly (GO:0043149)2.54403239
189positive regulation of epithelial cell migration (GO:0010634)2.53325821
190multicellular organismal metabolic process (GO:0044236)2.53051630
191regulation of macrophage cytokine production (GO:0010935)2.53050320
192multicellular organismal catabolic process (GO:0044243)2.52835514
193positive regulation of collagen biosynthetic process (GO:0032967)2.52394233
194* wound healing (GO:0042060)2.51700759
195prostanoid metabolic process (GO:0006692)2.50554288
196prostaglandin metabolic process (GO:0006693)2.50554288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.50954137
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.65660951
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.71489102
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.53320957
5* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.99096116
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.86998586
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.24231572
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.04880572
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.98671008
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91219499
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77375074
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.75300967
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.75300967
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.72104435
15CJUN_26792858_Chip-Seq_BT549_Human2.65144820
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.48741314
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47025678
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.46067191
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43414152
20GATA1_22025678_ChIP-Seq_K562_Human2.37951262
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36628596
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.35943804
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.34156107
24NRF2_20460467_ChIP-Seq_MEFs_Mouse2.33343385
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.33343385
26* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.32726260
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32640623
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.23923140
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.22145882
30CLOCK_20551151_ChIP-Seq_293T_Human2.20281575
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12713105
32BRD4_25478319_ChIP-Seq_HGPS_Human2.05652899
33WT1_19549856_ChIP-ChIP_CCG9911_Human2.02283647
34* SOX2_20726797_ChIP-Seq_SW620_Human1.99439628
35TP53_18474530_ChIP-ChIP_U2OS_Human1.97536175
36SCL_19346495_ChIP-Seq_HPC-7_Human1.94971419
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.92774261
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89052061
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89040962
40TP53_16413492_ChIP-PET_HCT116_Human1.87630736
41SPI1_23547873_ChIP-Seq_NB4_Human1.87553574
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87352544
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78977593
44CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78235110
45ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.74059801
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.73991838
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.72660237
48JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.70422225
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.63150804
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62554639
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62247906
52* FOXO3_23340844_ChIP-Seq_DLD1_Human1.61902548
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61609405
54P63_26484246_Chip-Seq_KERATINOCYTES_Human1.60316376
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57792458
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55186042
57ATF3_27146783_Chip-Seq_COLON_Human1.54168582
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52434180
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49501445
60UBF1/2_26484160_Chip-Seq_HMECs_Human1.48494640
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48130197
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47377322
63MYB_26560356_Chip-Seq_TH2_Human1.45430957
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.44810285
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43389640
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43389640
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43389640
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42538667
69VDR_24763502_ChIP-Seq_THP-1_Human1.40953174
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.39479543
71ZNF263_19887448_ChIP-Seq_K562_Human1.38077138
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33014277
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32399823
74PU_27001747_Chip-Seq_BMDM_Mouse1.31743370
75GATA3_26560356_Chip-Seq_TH2_Human1.30458065
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30175854
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27417023
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.24509246
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22887496
80SMC1_22415368_ChIP-Seq_MEFs_Mouse1.22641716
81* TP63_23658742_ChIP-Seq_EP156T_Human1.22567572
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22520887
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.22142355
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19558700
85KLF5_25053715_ChIP-Seq_YYC3_Human1.17335481
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.17099012
87ELK1_19687146_ChIP-ChIP_HELA_Human1.17036140
88ELK3_25401928_ChIP-Seq_HUVEC_Human1.16834154
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16669850
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.14351776
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13898348
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13301242
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12139903
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.11639889
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10742602
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10509683
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10114421
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08215380
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06550394
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06206595
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05729740
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05108656
103RUNX_20019798_ChIP-Seq_JUKART_Human1.02329195
104ELF5_23300383_ChIP-Seq_T47D_Human1.00944416
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.00725539
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00280715
107RXR_22108803_ChIP-Seq_LS180_Human1.00032179
108TP53_22127205_ChIP-Seq_IMR90_Human0.99325791
109TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98399020
110MYB_26560356_Chip-Seq_TH1_Human0.97394764
111CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96753644
112VDR_24787735_ChIP-Seq_THP-1_Human0.96666029
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96635039
114TFEB_21752829_ChIP-Seq_HELA_Human0.96469473
115DCP1A_22483619_ChIP-Seq_HELA_Human0.95540621
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94809266
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94452187
118GATA3_27048872_Chip-Seq_THYMUS_Human0.94107074
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92959329
120RACK7_27058665_Chip-Seq_MCF-7_Human0.90355477
121SPI1_23127762_ChIP-Seq_K562_Human0.90177423
122GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90096036
123ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89991974
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88904289
125GATA4_25053715_ChIP-Seq_YYC3_Human0.87305307
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86951907
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86448921
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.86264068
129* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86252923
130* NFI_21473784_ChIP-Seq_ESCs_Mouse0.85562286
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84743166
132HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84003222
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83744117
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82859662
135VDR_21846776_ChIP-Seq_THP-1_Human0.82279797
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81911503
137CDX2_22108803_ChIP-Seq_LS180_Human0.81624817
138SMC3_22415368_ChIP-Seq_MEFs_Mouse0.79704693
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.79233511
140* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.78541226
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.77633982
142STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76190250
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.74682472
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74096309
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.73274183
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.70953821
147SA1_22415368_ChIP-Seq_MEFs_Mouse0.70187461
148GATA6_25053715_ChIP-Seq_YYC3_Human0.69363055
149* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69304002
150MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.67205770
151PIAS1_25552417_ChIP-Seq_VCAP_Human0.66685813
152BRD4_27068464_Chip-Seq_AML-cells_Mouse0.66178155
153AR_21909140_ChIP-Seq_LNCAP_Human0.65648039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.04149451
2MP0005275_abnormal_skin_tensile5.21203614
3MP0003705_abnormal_hypodermis_morpholog4.05188323
4MP0010352_gastrointestinal_tract_polyps3.97333948
5MP0008004_abnormal_stomach_pH2.96315561
6MP0009785_altered_susceptibility_to2.87293917
7MP0009764_decreased_sensitivity_to2.82242262
8MP0005503_abnormal_tendon_morphology2.79309344
9MP0006082_CNS_inflammation2.78409948
10MP0002060_abnormal_skin_morphology2.74360065
11MP0003279_aneurysm2.67164506
12MP0005023_abnormal_wound_healing2.65403736
13MP0005623_abnormal_meninges_morphology2.64869093
14MP0003303_peritoneal_inflammation2.58087076
15MP0002796_impaired_skin_barrier2.53766793
16MP0003566_abnormal_cell_adhesion2.50415747
17MP0005397_hematopoietic_system_phenotyp2.44063251
18MP0001545_abnormal_hematopoietic_system2.44063251
19MP0002877_abnormal_melanocyte_morpholog2.37562472
20MP0001853_heart_inflammation2.32173814
21MP0001958_emphysema2.27107336
22MP0001835_abnormal_antigen_presentation2.21460319
23MP0003941_abnormal_skin_development2.19777887
24MP0009384_cardiac_valve_regurgitation2.18989969
25MP0002419_abnormal_innate_immunity2.18962709
26MP0005000_abnormal_immune_tolerance2.16607613
27MP0005257_abnormal_intraocular_pressure2.15759935
28MP0001243_abnormal_dermal_layer2.15206671
29MP0003656_abnormal_erythrocyte_physiolo2.13474138
30MP0004808_abnormal_hematopoietic_stem2.12070267
31MP0002332_abnormal_exercise_endurance2.11765621
32MP0003075_altered_response_to2.04964979
33MP0009278_abnormal_bone_marrow2.02057557
34MP0003091_abnormal_cell_migration1.99805931
35MP0004272_abnormal_basement_membrane1.98712237
36MP0004185_abnormal_adipocyte_glucose1.94024115
37MP0002006_tumorigenesis1.89885546
38MP0005025_abnormal_response_to1.85488835
39MP0008961_abnormal_basal_metabolism1.84810474
40MP0010234_abnormal_vibrissa_follicle1.83137649
41MP0002452_abnormal_antigen_presenting1.83137515
42MP0005501_abnormal_skin_physiology1.80596598
43MP0005508_abnormal_skeleton_morphology1.77843013
44MP0003453_abnormal_keratinocyte_physiol1.75721329
45MP0006054_spinal_hemorrhage1.70424620
46MP0002723_abnormal_immune_serum1.69870530
47MP0003806_abnormal_nucleotide_metabolis1.65227048
48MP0005167_abnormal_blood-brain_barrier1.63304156
49MP0004510_myositis1.61541531
50MP0010030_abnormal_orbit_morphology1.60984863
51MP0000750_abnormal_muscle_regeneration1.59978183
52MP0001800_abnormal_humoral_immune1.59808445
53MP0005058_abnormal_lysosome_morphology1.59545363
54MP0009697_abnormal_copulation1.55083640
55MP0002295_abnormal_pulmonary_circulatio1.54868377
56MP0001542_abnormal_bone_strength1.54637649
57MP0005166_decreased_susceptibility_to1.54155529
58MP0003045_fibrosis1.53590346
59MP0009053_abnormal_anal_canal1.52783626
60MP0010771_integument_phenotype1.49186709
61* MP0010155_abnormal_intestine_physiology1.48771713
62MP0001790_abnormal_immune_system1.46763913
63MP0005387_immune_system_phenotype1.46763913
64MP0001216_abnormal_epidermal_layer1.44557102
65MP0009379_abnormal_foot_pigmentation1.44065671
66MP0008469_abnormal_protein_level1.42008817
67MP0002896_abnormal_bone_mineralization1.41997346
68MP0009250_abnormal_appendicular_skeleto1.41685048
69MP0005464_abnormal_platelet_physiology1.41519088
70MP0003724_increased_susceptibility_to1.41066472
71* MP0001845_abnormal_inflammatory_respons1.41061277
72MP0001819_abnormal_immune_cell1.39777528
73MP0010368_abnormal_lymphatic_system1.39227587
74MP0002420_abnormal_adaptive_immunity1.38866946
75MP0002405_respiratory_system_inflammati1.36668094
76MP0002009_preneoplasia1.36203910
77MP0009765_abnormal_xenobiotic_induced1.35169000
78MP0005390_skeleton_phenotype1.34466252
79MP0001299_abnormal_eye_distance/1.33456695
80MP0002168_other_aberrant_phenotype1.30144359
81MP0000733_abnormal_muscle_development1.27774190
82MP0005666_abnormal_adipose_tissue1.25465754
83* MP0004947_skin_inflammation1.23898095
84MP0003436_decreased_susceptibility_to1.22150266
85MP0003191_abnormal_cellular_cholesterol1.20842042
86MP0003300_gastrointestinal_ulcer1.20425296
87MP0001348_abnormal_lacrimal_gland1.19708630
88MP0003385_abnormal_body_wall1.18081401
89MP0002933_joint_inflammation1.16023256
90MP0001533_abnormal_skeleton_physiology1.15644272
91MP0005671_abnormal_response_to1.15412052
92MP0008057_abnormal_DNA_replication1.12194645
93MP0001501_abnormal_sleep_pattern1.11917643
94MP0005451_abnormal_body_composition1.11680303
95MP0005076_abnormal_cell_differentiation1.11646814
96MP0000383_abnormal_hair_follicle1.11062548
97MP0005164_abnormal_response_to1.08193609
98MP0003195_calcinosis1.07439005
99MP0002998_abnormal_bone_remodeling1.07029143
100MP0000767_abnormal_smooth_muscle1.06738994
101MP0001851_eye_inflammation1.01278358
102MP0002282_abnormal_trachea_morphology1.00947173
103MP0000685_abnormal_immune_system1.00040060
104MP0000716_abnormal_immune_system0.99863606
105MP0001873_stomach_inflammation0.99171873
106MP0009763_increased_sensitivity_to0.95894689
107MP0002398_abnormal_bone_marrow0.95258689
108MP0005165_increased_susceptibility_to0.94479663
109MP0008007_abnormal_cellular_replicative0.93913074
110MP0000647_abnormal_sebaceous_gland0.93171822
111MP0005266_abnormal_metabolism0.92254335
112MP0002113_abnormal_skeleton_development0.91960051
113MP0001191_abnormal_skin_condition0.90477437
114MP0003448_altered_tumor_morphology0.89440178
115MP0000762_abnormal_tongue_morphology0.89329650
116MP0003942_abnormal_urinary_system0.89268676
117MP0000467_abnormal_esophagus_morphology0.89222564
118MP0000377_abnormal_hair_follicle0.89197122
119MP0003795_abnormal_bone_structure0.88649438
120MP0003828_pulmonary_edema0.87834893
121MP0000163_abnormal_cartilage_morphology0.87574046
122MP0003950_abnormal_plasma_membrane0.87403876
123MP0001881_abnormal_mammary_gland0.87266913
124MP0000627_abnormal_mammary_gland0.87208746
125MP0000858_altered_metastatic_potential0.86904947
126MP0002139_abnormal_hepatobiliary_system0.86674991
127MP0005595_abnormal_vascular_smooth0.86365715
128MP0005535_abnormal_body_temperature0.85826272
129MP0000537_abnormal_urethra_morphology0.84943384
130MP0002115_abnormal_skeleton_extremities0.84820416
131MP0003172_abnormal_lysosome_physiology0.83578739
132MP0009931_abnormal_skin_appearance0.83180769
133MP0003755_abnormal_palate_morphology0.83149160
134MP0005647_abnormal_sex_gland0.82468812
135MP0002429_abnormal_blood_cell0.82256907
136MP0001177_atelectasis0.81150885
137MP0005376_homeostasis/metabolism_phenot0.80371065
138MP0000689_abnormal_spleen_morphology0.79901282
139MP0000343_altered_response_to0.79413481
140MP0010307_abnormal_tumor_latency0.77952059
141MP0003937_abnormal_limbs/digits/tail_de0.76373939
142MP0002177_abnormal_outer_ear0.76238914
143MP0002722_abnormal_immune_system0.75823190
144MP0004883_abnormal_blood_vessel0.75447029
145MP0009840_abnormal_foam_cell0.75292684
146MP0002138_abnormal_hepatobiliary_system0.75078740
147MP0009333_abnormal_splenocyte_physiolog0.74125326
148MP0001727_abnormal_embryo_implantation0.73664479
149MP0005310_abnormal_salivary_gland0.72977372
150MP0000579_abnormal_nail_morphology0.72619578
151MP0000432_abnormal_head_morphology0.71752903
152MP0008875_abnormal_xenobiotic_pharmacok0.71337912
153MP0005388_respiratory_system_phenotype0.70734721
154MP0002133_abnormal_respiratory_system0.70734721
155MP0001879_abnormal_lymphatic_vessel0.68633244
156MP0005197_abnormal_uvea_morphology0.68067200
157MP0000428_abnormal_craniofacial_morphol0.67148414
158MP0000427_abnormal_hair_cycle0.66146306
159MP0003115_abnormal_respiratory_system0.64668149
160MP0001614_abnormal_blood_vessel0.64526576
161MP0002128_abnormal_blood_circulation0.64356050
162MP0005395_other_phenotype0.64096573
163MP0000249_abnormal_blood_vessel0.62961481
164MP0002108_abnormal_muscle_morphology0.61998494
165MP0002148_abnormal_hypersensitivity_rea0.61865018
166MP0002098_abnormal_vibrissa_morphology0.60514649
167MP0001175_abnormal_lung_morphology0.57860086
168MP0010678_abnormal_skin_adnexa0.57555670
169MP0001340_abnormal_eyelid_morphology0.57344541
170MP0005375_adipose_tissue_phenotype0.57290776

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.27837376
2Protrusio acetabuli (HP:0003179)7.01599667
3Abnormality of liposaccharide metabolism (HP:0010968)5.20477544
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.20477544
5Abnormality of glycolipid metabolism (HP:0010969)5.20477544
6Atrophic scars (HP:0001075)5.03262488
7Peritonitis (HP:0002586)4.71595238
8Stomatitis (HP:0010280)4.62288050
9Aortic dissection (HP:0002647)4.56815782
10Autoimmune thrombocytopenia (HP:0001973)4.27853944
11Shallow orbits (HP:0000586)4.19855333
12Fragile skin (HP:0001030)4.10710747
13Autoimmune hemolytic anemia (HP:0001890)4.10467990
14Soft skin (HP:0000977)4.09009791
15Disinhibition (HP:0000734)4.03246626
16Retrobulbar optic neuritis (HP:0100654)4.00771458
17Optic neuritis (HP:0100653)4.00771458
18Dilatation of the ascending aorta (HP:0005111)3.79458455
19Orchitis (HP:0100796)3.76771891
20Myositis (HP:0100614)3.75631601
21Short nail (HP:0001799)3.74668294
22Elevated erythrocyte sedimentation rate (HP:0003565)3.72632976
23Cervical subluxation (HP:0003308)3.69076399
24Vacuolated lymphocytes (HP:0001922)3.63527904
25Cerebral aneurysm (HP:0004944)3.54657175
26Genu recurvatum (HP:0002816)3.39102389
27Aortic aneurysm (HP:0004942)3.35635419
28Vertebral compression fractures (HP:0002953)3.33297463
29Mediastinal lymphadenopathy (HP:0100721)3.29223227
30Abnormality of macrophages (HP:0004311)3.21210741
31Increased connective tissue (HP:0009025)3.18561992
32Recurrent bacterial skin infections (HP:0005406)3.14388084
33Keratoconjunctivitis sicca (HP:0001097)3.14295227
34Acute lymphatic leukemia (HP:0006721)3.12091874
35Gangrene (HP:0100758)3.08976576
36Osteolytic defects of the phalanges of the hand (HP:0009771)3.07928580
37Osteolytic defects of the hand bones (HP:0009699)3.07928580
38Keratoconjunctivitis (HP:0001096)2.97930914
39Abnormality of dentin (HP:0010299)2.97216775
40Neonatal short-limb short stature (HP:0008921)2.96163072
41Wormian bones (HP:0002645)2.91123078
42Mitral valve prolapse (HP:0001634)2.88437019
43Vasculitis (HP:0002633)2.88408101
44Diaphragmatic weakness (HP:0009113)2.87031670
45Biconcave vertebral bodies (HP:0004586)2.84972796
46Parakeratosis (HP:0001036)2.81729693
47Loss of speech (HP:0002371)2.81523093
48Distal lower limb amyotrophy (HP:0008944)2.81149548
49Amyloidosis (HP:0011034)2.80942989
50Conjugated hyperbilirubinemia (HP:0002908)2.80176422
51Increased density of long bones (HP:0006392)2.79668401
52Recurrent abscess formation (HP:0002722)2.76768252
53Subacute progressive viral hepatitis (HP:0006572)2.74185167
54Ankle contracture (HP:0006466)2.72113986
55Syringomyelia (HP:0003396)2.71568468
56Spinal cord lesions (HP:0100561)2.71568468
57Coronal craniosynostosis (HP:0004440)2.71396896
58Increased serum ferritin (HP:0003281)2.68194178
59Blue sclerae (HP:0000592)2.67394426
60Spinal rigidity (HP:0003306)2.65713597
61Thin bony cortex (HP:0002753)2.64134528
62Wrist flexion contracture (HP:0001239)2.63226422
63Acute myeloid leukemia (HP:0004808)2.62519049
64Abnormal delivery (HP:0001787)2.60341360
65Dysostosis multiplex (HP:0000943)2.59501303
66Bladder diverticulum (HP:0000015)2.58900595
67Abnormality of B cell number (HP:0010975)2.56491251
68Interstitial pulmonary disease (HP:0006530)2.53887170
69Recurrent viral infections (HP:0004429)2.53286802
70Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46479164
71Mutism (HP:0002300)2.44355842
72Increased cerebral lipofuscin (HP:0011813)2.43534936
73Tibial bowing (HP:0002982)2.43443338
74Abnormality of the distal phalanges of the toes (HP:0010182)2.41508072
75Progressive external ophthalmoplegia (HP:0000590)2.41489416
76Pulmonary infiltrates (HP:0002113)2.41235227
77B lymphocytopenia (HP:0010976)2.37402221
78Aplasia involving bones of the extremities (HP:0009825)2.35331972
79Aplasia involving bones of the upper limbs (HP:0009823)2.35331972
80Aplasia of the phalanges of the hand (HP:0009802)2.35331972
81Fused cervical vertebrae (HP:0002949)2.35161852
82Myocardial infarction (HP:0001658)2.34850721
83Natal tooth (HP:0000695)2.34335394
84Inappropriate behavior (HP:0000719)2.33358695
85Nausea (HP:0002018)2.33234010
86Viral hepatitis (HP:0006562)2.32637926
87Alopecia of scalp (HP:0002293)2.31626011
88Gastrointestinal infarctions (HP:0005244)2.31305424
89Right ventricular cardiomyopathy (HP:0011663)2.30795579
90Hematochezia (HP:0002573)2.29771844
91Choroideremia (HP:0001139)2.29332696
92Hyperextensible skin (HP:0000974)2.26986079
93Elbow flexion contracture (HP:0002987)2.25625430
94Broad metatarsal (HP:0001783)2.24647011
95Broad face (HP:0000283)2.22149880
96Mesomelia (HP:0003027)2.21846976
97Overgrowth (HP:0001548)2.20709097
98Spinal cord compression (HP:0002176)2.20022236
99Distal lower limb muscle weakness (HP:0009053)2.19247546
100Follicular hyperkeratosis (HP:0007502)2.19053538
101Mitral regurgitation (HP:0001653)2.16120744
102Cardiovascular calcification (HP:0011915)2.15800798
103Nuclear cataract (HP:0100018)2.15443068
104Alveolar cell carcinoma (HP:0006519)2.10678082
105Thrombocytosis (HP:0001894)2.10437398
106Increased mean platelet volume (HP:0011877)2.08862217
107Infantile muscular hypotonia (HP:0008947)2.08408803
108Arterial thrombosis (HP:0004420)2.07882901
109Hemoptysis (HP:0002105)2.07704874
110Polyneuropathy (HP:0001271)2.07499771
111Bronchomalacia (HP:0002780)2.06481548
112Amaurosis fugax (HP:0100576)2.06025874
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.05451155
114Prostate neoplasm (HP:0100787)2.05287420
115Deviation of the hallux (HP:0010051)2.05278684
116Radial bowing (HP:0002986)2.04779067
117Abnormality of iron homeostasis (HP:0011031)2.04612058
118Achilles tendon contracture (HP:0001771)2.04599849
119Abnormality of the acetabulum (HP:0003170)2.04012873
120Posterior subcapsular cataract (HP:0007787)2.03749728
121Erythroderma (HP:0001019)2.02546894
122Scapular winging (HP:0003691)2.02395658
123Abnormal blistering of the skin (HP:0008066)2.01409086
124Lower limb amyotrophy (HP:0007210)2.00872609
125Vascular tortuosity (HP:0004948)2.00546430
126Onycholysis (HP:0001806)1.98478392
127Neurofibrillary tangles (HP:0002185)1.98092649
128Hallux valgus (HP:0001822)1.97897516
129Leukocytosis (HP:0001974)1.97413120
130Difficulty climbing stairs (HP:0003551)1.97365666
131Erythema (HP:0010783)1.96867507
132Venous abnormality (HP:0002624)1.96809315
133Anorexia (HP:0002039)1.96222029
134Bell-shaped thorax (HP:0001591)1.95676842
135Fibular aplasia (HP:0002990)1.95495456
136Abnormality of the peritoneum (HP:0002585)1.94733855
137Fragile nails (HP:0001808)1.94170067
138Glomerulopathy (HP:0100820)1.93511518
139Cone-rod dystrophy (HP:0000548)1.93313940
140Round ear (HP:0100830)1.92450906
141Camptodactyly of toe (HP:0001836)1.92048291
142Increased neuronal autofluorescent lipopigment (HP:0002074)1.91252771
143Abnormality of the calcaneus (HP:0008364)1.90998029
144Neoplasm of the tracheobronchial system (HP:0100552)1.90870920
145Joint swelling (HP:0001386)1.90268995
146Hypergammaglobulinemia (HP:0010702)1.89713306
147Increased IgM level (HP:0003496)1.88177803
148Urticaria (HP:0001025)1.88058263
149Apathy (HP:0000741)1.87901986
150Pustule (HP:0200039)1.87215447
151Femoral bowing (HP:0002980)1.87103571
152Thick nail (HP:0001805)1.85348909
153Petechiae (HP:0000967)1.84726951
154Arthralgia (HP:0002829)1.83842449
155Aneurysm (HP:0002617)1.83510377
156Bowel diverticulosis (HP:0005222)1.83346187
157Fatigue (HP:0012378)1.82757703
158Abnormality of the 2nd finger (HP:0004100)1.81721617
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81029277
160Plantar hyperkeratosis (HP:0007556)1.80652569
161Diminished motivation (HP:0000745)1.79598413
162Mildly elevated creatine phosphokinase (HP:0008180)1.79398753
163Abnormality of polysaccharide metabolism (HP:0011012)1.79307172
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79307172
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79307172
166Hepatosplenomegaly (HP:0001433)1.79051171
167Abnormality of the Achilles tendon (HP:0005109)1.79042329
168Recurrent skin infections (HP:0001581)1.78408328
169Abnormality of the umbilical cord (HP:0010881)1.78186185
170Somatic mutation (HP:0001428)1.77977769
171Wide anterior fontanel (HP:0000260)1.77508763
172Micronodular cirrhosis (HP:0001413)1.77409306
173Recurrent fungal infections (HP:0002841)1.77382295
174Abnormal platelet volume (HP:0011876)1.77089234
175Coxa vara (HP:0002812)1.76798413
176Upper limb muscle weakness (HP:0003484)1.76463969
177Oral leukoplakia (HP:0002745)1.76283034
178Congenital ichthyosiform erythroderma (HP:0007431)1.75802195
179Flat occiput (HP:0005469)1.74540443
180Abnormality of the proximal phalanges of the hand (HP:0009834)1.74325082
181Thoracolumbar scoliosis (HP:0002944)1.73410929
182Abnormality of the basal ganglia (HP:0002134)1.73341021
183Impaired platelet aggregation (HP:0003540)1.73305363
184Abnormal platelet function (HP:0011869)1.73305363
185Eosinophilia (HP:0001880)1.72974388
186Microglossia (HP:0000171)1.72550170
187Cheilitis (HP:0100825)1.72545153
188Insomnia (HP:0100785)1.72336424
189Thin skin (HP:0000963)1.70205183
190Decreased skull ossification (HP:0004331)1.68992928
191Bowed forearm bones (HP:0003956)1.68985924
192Bowing of the arm (HP:0006488)1.68985924
193Milia (HP:0001056)1.68669838
194Asymmetry of the thorax (HP:0001555)1.67307062
195Abnormality of the nasal septum (HP:0000419)1.66142695
196Persistence of primary teeth (HP:0006335)1.66081367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.96390702
2EPHA24.27961614
3DDR23.94757700
4TTN3.76359620
5BMPR23.26670826
6FER3.16317602
7LATS13.03894774
8TRIB32.95047821
9EPHB22.67572651
10PKN22.42849839
11PDGFRA2.35874894
12TRPM72.32333493
13PIM22.27644375
14GRK72.09105699
15STK392.07492265
16TAOK22.05607876
17TESK12.05379899
18BMX1.99152355
19EIF2AK31.98886650
20LIMK11.89022828
21TAOK31.87290345
22LRRK21.86194638
23RPS6KA41.83270330
24STK31.76234830
25PAK21.72871718
26LATS21.71168671
27PTK21.70132014
28MST1R1.65685699
29NEK91.63263264
30MOS1.61378234
31NME21.59282600
32ERBB31.59013992
33RIPK11.55677790
34SIK31.50528041
35MATK1.49502569
36PIK3CG1.41061453
37FRK1.38316860
38ERN11.37763711
39IKBKE1.37267788
40PAK41.37254092
41MAP3K141.36904053
42WNK41.35820181
43PAK31.35391782
44TNIK1.30325195
45PTK61.30312020
46MAP3K31.28893329
47PRPF4B1.24500441
48STK101.23499723
49DMPK1.23422539
50MKNK11.15174405
51CSK1.13922472
52IRAK41.11590165
53MET1.11110228
54FGFR11.05362990
55FGR1.03280002
56CDK61.02775609
57CSF1R1.02663509
58PDGFRB1.00333428
59ERBB41.00040023
60TEC0.97703391
61TXK0.95253855
62ABL20.94964280
63JAK30.90511542
64EPHA30.89317106
65PIK3CA0.87683088
66MAP2K10.87351924
67TBK10.86592410
68MST40.83771440
69ADRBK20.83535456
70TESK20.79517471
71MAP3K50.78660599
72SCYL20.78365590
73TRIM280.77695210
74MAP2K30.75778466
75MAPKAPK30.75685511
76PTK2B0.74811610
77ROCK10.74032312
78MAP3K110.73967593
79INSR0.71204525
80PLK40.70365660
81STK38L0.68404092
82IKBKB0.66832534
83MKNK20.65797955
84MAP3K80.64895821
85TLK10.63827723
86JAK10.63595461
87PLK20.61355962
88DYRK1B0.60661431
89KIT0.59811308
90BLK0.59021102
91PRKG20.58465029
92ADRBK10.58348711
93IRAK10.55205710
94RPS6KB20.53727852
95NUAK10.52902331
96MAPKAPK50.51919028
97HCK0.51885269
98EPHB10.51848600
99TGFBR20.50921158
100ABL10.50812434
101CCNB10.50423229
102PRKD20.50098415
103IRAK20.48487055
104DAPK30.47977645
105CDK90.47782125
106ZAK0.47724989
107ILK0.47471616
108NEK20.47130210
109STK240.46755581
110ACVR1B0.46600602
111TYK20.46440175
112BRD40.45720372
113FES0.45248870
114ERBB20.44228059
115PDK20.43046990
116EGFR0.42869800
117EIF2AK10.42698801
118MELK0.41622161
119MTOR0.40724494
120CSNK1A1L0.38655448
121TIE10.38177720
122MAP3K10.38146913
123PBK0.38123099
124MAP3K20.37443961
125MAPKAPK20.36840241
126TGFBR10.36579117
127PRKCQ0.36227553
128MAP3K120.36058347
129PRKCE0.34974597
130MAP3K130.34313753
131FLT30.34297343
132TAOK10.33568730
133CHUK0.33297403
134SRC0.33210273
135GSK3A0.32999532
136EEF2K0.32631173
137CDK80.32354806
138EIF2AK20.32332375
139ALK0.32269314
140BCR0.31765391
141ROCK20.31079853
142CAMK2D0.30476832
143IGF1R0.30256632
144SIK10.28140361
145LYN0.28009111
146JAK20.27054450
147RIPK40.23897120
148BMPR1B0.23889290
149MARK30.22761269
150HIPK20.20557339
151MAP2K60.19912622
152LCK0.18693329
153CLK10.18332514
154WNK10.17481742
155CHEK20.16977675
156PIM10.16934805
157BRSK20.16800358

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051443.29560553
2ECM-receptor interaction_Homo sapiens_hsa045123.24298565
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.22880640
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.55205062
5Bladder cancer_Homo sapiens_hsa052192.51584318
6Proteoglycans in cancer_Homo sapiens_hsa052052.38907232
7Focal adhesion_Homo sapiens_hsa045102.32931845
8TNF signaling pathway_Homo sapiens_hsa046682.27941342
9Asthma_Homo sapiens_hsa053102.25385886
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.23323728
11Amoebiasis_Homo sapiens_hsa051462.14861601
12Small cell lung cancer_Homo sapiens_hsa052222.05489434
13Adherens junction_Homo sapiens_hsa045201.97799679
14Allograft rejection_Homo sapiens_hsa053301.97632521
15Leishmaniasis_Homo sapiens_hsa051401.91509114
16MicroRNAs in cancer_Homo sapiens_hsa052061.91241323
17Other glycan degradation_Homo sapiens_hsa005111.89874805
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.87928286
19Rheumatoid arthritis_Homo sapiens_hsa053231.87845119
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87694482
21Type I diabetes mellitus_Homo sapiens_hsa049401.82949586
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82945584
23TGF-beta signaling pathway_Homo sapiens_hsa043501.75041411
24p53 signaling pathway_Homo sapiens_hsa041151.73621624
25Salmonella infection_Homo sapiens_hsa051321.72827197
26Shigellosis_Homo sapiens_hsa051311.68505067
27Herpes simplex infection_Homo sapiens_hsa051681.68437340
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.67728276
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.60895727
30Legionellosis_Homo sapiens_hsa051341.54523635
31Hematopoietic cell lineage_Homo sapiens_hsa046401.54155273
32Melanoma_Homo sapiens_hsa052181.53955228
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.51721409
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51430014
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46959466
36Hippo signaling pathway_Homo sapiens_hsa043901.44984669
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43825539
38Fatty acid biosynthesis_Homo sapiens_hsa000611.41458088
39Pertussis_Homo sapiens_hsa051331.40850477
40Chronic myeloid leukemia_Homo sapiens_hsa052201.38987496
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.36978242
42Phagosome_Homo sapiens_hsa041451.32944295
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29566467
44Dilated cardiomyopathy_Homo sapiens_hsa054141.25931938
45Tight junction_Homo sapiens_hsa045301.23228119
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.23138298
47Graft-versus-host disease_Homo sapiens_hsa053321.21737462
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16093653
49Autoimmune thyroid disease_Homo sapiens_hsa053201.11655702
50Arachidonic acid metabolism_Homo sapiens_hsa005901.07899161
51Protein digestion and absorption_Homo sapiens_hsa049741.07623085
52Staphylococcus aureus infection_Homo sapiens_hsa051501.06259120
53Tuberculosis_Homo sapiens_hsa051521.03542217
54Toxoplasmosis_Homo sapiens_hsa051451.02390208
55B cell receptor signaling pathway_Homo sapiens_hsa046621.02054683
56Apoptosis_Homo sapiens_hsa042101.01896539
57Osteoclast differentiation_Homo sapiens_hsa043801.01772576
58Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01076756
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.99056643
60Platelet activation_Homo sapiens_hsa046110.97872240
61Pancreatic cancer_Homo sapiens_hsa052120.97771869
62Viral myocarditis_Homo sapiens_hsa054160.96916522
63Rap1 signaling pathway_Homo sapiens_hsa040150.94073434
64VEGF signaling pathway_Homo sapiens_hsa043700.94059934
65Antigen processing and presentation_Homo sapiens_hsa046120.92184903
66Glioma_Homo sapiens_hsa052140.87779197
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87454542
68HIF-1 signaling pathway_Homo sapiens_hsa040660.85796527
69Sphingolipid metabolism_Homo sapiens_hsa006000.84709874
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84128241
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83750649
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.83624263
73Pathways in cancer_Homo sapiens_hsa052000.82742924
74Prostate cancer_Homo sapiens_hsa052150.80685072
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80539470
76Viral carcinogenesis_Homo sapiens_hsa052030.78781949
77Hepatitis B_Homo sapiens_hsa051610.78006170
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77503462
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76667152
80Epstein-Barr virus infection_Homo sapiens_hsa051690.76568446
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.76544736
82T cell receptor signaling pathway_Homo sapiens_hsa046600.75451530
83HTLV-I infection_Homo sapiens_hsa051660.72288613
84Mineral absorption_Homo sapiens_hsa049780.70885526
85Thyroid cancer_Homo sapiens_hsa052160.66463239
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66090813
87Prolactin signaling pathway_Homo sapiens_hsa049170.65303290
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64635982
89Olfactory transduction_Homo sapiens_hsa047400.64436409
90Basal cell carcinoma_Homo sapiens_hsa052170.63155149
91African trypanosomiasis_Homo sapiens_hsa051430.62752203
92Ovarian steroidogenesis_Homo sapiens_hsa049130.62032739
93Sulfur metabolism_Homo sapiens_hsa009200.60522153
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.60452746
95Steroid biosynthesis_Homo sapiens_hsa001000.60088372
96Axon guidance_Homo sapiens_hsa043600.59526156
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.58808658
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57670397
99Ras signaling pathway_Homo sapiens_hsa040140.57347585
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55788793
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53449225
102Wnt signaling pathway_Homo sapiens_hsa043100.52494728
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.52192574
104Hedgehog signaling pathway_Homo sapiens_hsa043400.50820045
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50697572
106Renal cell carcinoma_Homo sapiens_hsa052110.49824375
107Measles_Homo sapiens_hsa051620.46961889
108Basal transcription factors_Homo sapiens_hsa030220.46791025
109Hepatitis C_Homo sapiens_hsa051600.46136744
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46041722
111Non-homologous end-joining_Homo sapiens_hsa034500.43627412
112Lysosome_Homo sapiens_hsa041420.43594809
113Systemic lupus erythematosus_Homo sapiens_hsa053220.42704396
114Acute myeloid leukemia_Homo sapiens_hsa052210.42144659
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41943805
116Endocytosis_Homo sapiens_hsa041440.41188945
117MAPK signaling pathway_Homo sapiens_hsa040100.41096652
118Influenza A_Homo sapiens_hsa051640.40172202
119Chemical carcinogenesis_Homo sapiens_hsa052040.40039523
120Complement and coagulation cascades_Homo sapiens_hsa046100.39203209
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37853193
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37344423
123GnRH signaling pathway_Homo sapiens_hsa049120.37105587
124* ErbB signaling pathway_Homo sapiens_hsa040120.37050670
125Renin-angiotensin system_Homo sapiens_hsa046140.36733471
126Prion diseases_Homo sapiens_hsa050200.36104306
127Melanogenesis_Homo sapiens_hsa049160.36081332
128Dorso-ventral axis formation_Homo sapiens_hsa043200.35186695
129Chemokine signaling pathway_Homo sapiens_hsa040620.34796077
130Type II diabetes mellitus_Homo sapiens_hsa049300.31718834
131Tryptophan metabolism_Homo sapiens_hsa003800.29873371
132FoxO signaling pathway_Homo sapiens_hsa040680.27548419
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27068575
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26342049
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22727166
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.21609728
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19134119
138Insulin resistance_Homo sapiens_hsa049310.18740345
139Pyrimidine metabolism_Homo sapiens_hsa002400.17063851
140Ether lipid metabolism_Homo sapiens_hsa005650.12065787
141RNA degradation_Homo sapiens_hsa030180.11927087

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